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4. Cell Culture Differentiation and Proliferation Conditions Influence the In Vitro Regeneration of the Human Airway Epithelium

Author

Redman, Elisa, primary, Fierville, Morgane, additional, Cavard, Amélie, additional, Plaisant, Magali, additional, Arguel, Marie-Jeanne, additional, Ruiz Garcia, Sandra, additional, McAndrew, Eamon M., additional, Girard-Riboulleau, Cédric, additional, Lebrigand, Kevin, additional, Magnone, Virginie, additional, Ponzio, Gilles, additional, Gras, Delphine, additional, Chanez, Pascal, additional, Abelanet, Sophie, additional, Barbry, Pascal, additional, Marcet, Brice, additional, and Zaragosi, Laure-Emmanuelle, additional

Published
2024
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5. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Author

Banovich, Nicholas, Barbry, Pascal, Brazma, Alvis, Desai, Tushar, Duong, Thu Elizabeth, Eickelberg, Oliver, Falk, Christine, Farzan, Michael, Glass, Ian, Haniffa, Muzlifah, Horvath, Peter, Hung, Deborah, Kaminski, Naftali, Krasnow, Mark, Kropski, Jonathan A., Kuhnemund, Malte, Lafyatis, Robert, Lee, Haeock, Leroy, Sylvie, Linnarson, Sten, Lundeberg, Joakim, Meyer, Kerstin, Misharin, Alexander, Nawijn, Martijn, Nikolic, Marko Z., Ordovas-Montanes, Jose, Pe’er, Dana, Powell, Joseph, Quake, Stephen, Rajagopal, Jay, Tata, Purushothama Rao, Rawlins, Emma L., Regev, Aviv, Reyfman, Paul A., Rojas, Mauricio, Rosen, Orit, Saeb-Parsy, Kourosh, Samakovlis, Christos, Schiller, Herbert, Schultze, Joachim L., Seibold, Max A., Shalek, Alex K., Shepherd, Douglas, Spence, Jason, Spira, Avrum, Sun, Xin, Teichmann, Sarah, Theis, Fabian, Tsankov, Alexander, van den Berge, Maarten, von Papen, Michael, Whitsett, Jeffrey, Xavier, Ramnik, Xu, Yan, Zaragosi, Laure-Emmanuelle, Zhang, Kun, Ziegler, Carly G.K., Allon, Samuel J., Nyquist, Sarah K., Mbano, Ian M., Miao, Vincent N., Tzouanas, Constantine N., Cao, Yuming, Yousif, Ashraf S., Bals, Julia, Hauser, Blake M., Feldman, Jared, Muus, Christoph, Wadsworth, Marc H., II, Kazer, Samuel W., Hughes, Travis K., Doran, Benjamin, Gatter, G. James, Vukovic, Marko, Taliaferro, Faith, Mead, Benjamin E., Guo, Zhiru, Wang, Jennifer P., Gras, Delphine, Plaisant, Magali, Ansari, Meshal, Angelidis, Ilias, Adler, Heiko, Sucre, Jennifer M.S., Taylor, Chase J., Lin, Brian, Waghray, Avinash, Mitsialis, Vanessa, Dwyer, Daniel F., Buchheit, Kathleen M., Boyce, Joshua A., Barrett, Nora A., Laidlaw, Tanya M., Carroll, Shaina L., Colonna, Lucrezia, Tkachev, Victor, Peterson, Christopher W., Yu, Alison, Zheng, Hengqi Betty, Gideon, Hannah P., Winchell, Caylin G., Lin, Philana Ling, Bingle, Colin D., Snapper, Scott B., Theis, Fabian J., Schiller, Herbert B., Leslie, Alasdair, Kiem, Hans-Peter, Flynn, JoAnne L., Fortune, Sarah M., Berger, Bonnie, Finberg, Robert W., Kean, Leslie S., Garber, Manuel, Schmidt, Aaron G., and Lingwood, Daniel

Published
2020
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6. Cell culture differentiation and proliferation conditions influence thein vitroregeneration of the human airway epithelium

Author

Redman, Elisa, primary, Fierville, Morgane, additional, Cavard, Amélie, additional, Plaisant, Magali, additional, Arguel, Marie-Jeanne, additional, Ruiz Garcia, Sandra, additional, McAndrew, Eamon M, additional, Girard-Riboulleau, Cédric, additional, Lebrigand, Kevin, additional, Magnone, Virginie, additional, Ponzio, Gilles, additional, Gras, Delphine, additional, Chanez, Pascal, additional, Abelanet, Sophie, additional, Barbry, Pascal, additional, Marcet, Brice, additional, and Zaragosi, Laure-Emmanuelle, additional

Published
2024
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7. Protein crystallization promotes type 2 immunity and is reversible by antibody treatment

Author

Persson, Emma K., Verstraete, Kenneth, Heyndrickx, Ines, Gevaert, Elien, Aegerter, Helena, Percier, Jean-Michel, Deswarte, Kim, Verschueren, Koen H. G., Dansercoer, Ann, Gras, Delphine, Chanez, Pascal, Bachert, Claus, Gonçalves, Amanda, Van Gorp, Hanne, De Haard, Hans, Blanchetot, Christophe, Saunders, Michael, Hammad, Hamida, Savvides, Savvas N., and Lambrecht, Bart N.

Published
2019

17. Computed tomographic airway morphology after targeted lung denervation treatment in COPD

Author

Hartman, Jorine E., primary, Herth, Felix J.F., additional, Shah, Pallav, additional, Pison, Christophe, additional, Valipour, Arschang, additional, Slebos, Dirk-Jan, additional, Abele, Christine, additional, Firlinger, Irene, additional, Kothakuzhakal, Kiran, additional, Duller, Marina, additional, Lamprecht, Bernd, additional, Kropfmueller, Roland, additional, Holzmann, Kornelia, additional, Rathmeier, Sandra, additional, Hubner, Ralf, additional, Erdmann, Leonore, additional, Temmesfeld-Wollbrück, Bettina, additional, Ruwwe Glösenkamp, Christoph, additional, Gesierich, Wolfgang, additional, Reichenberger, Frank, additional, Niehaus, Christa, additional, Herth, Felix, additional, Eberhardt, Ralf, additional, Gompelmann, Daniela, additional, Rump, Brigitte, additional, Darwiche, Kaid, additional, Eisenmann, Stephan, additional, Kaiser, Ulrike, additional, Schwarz, Birte, additional, Sampel, Ulrike, additional, Schumann, Christian, additional, Kaiser, Robert, additional, Schumann-Stoiber, Kathryn, additional, Skowasch, Dirk, additional, Ring, Sabine, additional, Briault, Amandine, additional, Arbib, Francois, additional, Jondot, Marie, additional, Perez, Thierry, additional, Fournier, Clement, additional, Matran, Regis, additional, Catto, Michele, additional, Bautin, Nathalie, additional, De Broucker, Virginie, additional, Willemin, Marie, additional, Prevotat, Anne, additional, Wemeau, Ludivine, additional, Gicquello, Alice, additional, Foulon, Morgane, additional, Camara, Hasna, additional, Deslee, Gaetan, additional, Vallerand, Herve, additional, Dury, Sandra, additional, Gras, Delphine, additional, Bonnaire-Verdier, Margaux, additional, Kessler, Romain, additional, Hirschi, Sandrine, additional, Porzio, Michele, additional, Degot, Tristan, additional, Canuet, Mathieu, additional, Schuller, Armelle, additional, Stauder, Julien, additional, Azouaou, Sahra Ali, additional, Marceau, Armelle, additional, Mal, Hervé, additional, Costa, Yolande, additional, Shah, Pallav L., additional, Garner, Justin, additional, Srikanthan, Karthi, additional, Caneja, Cielito, additional, Thornton, John, additional, Hacken, Nick Ten, additional, Hartman, Jorine, additional, Klooster, Karin, additional, Augustijn, Sonja, additional, Bonta, Peter, additional, Annema, Jouke, additional, van de Pol, Marianne, additional, and Goorsenberg, Annika, additional

Published
2023
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18. Computed tomographic airway morphology after targeted lung denervation treatment in COPD

Author

Valipour, Arschang, Abele, Christine, Firlinger, Irene, Kothakuzhakal, Kiran, Duller, Marina, Lamprecht, Bernd, Kropfmueller, Roland, Holzmann, Kornelia, Rathmeier, Sandra, Hubner, Ralf, Erdmann, Leonore, Temmesfeld-Wollbrück, Bettina, Ruwwe Glösenkamp, Christoph, Gesierich, Wolfgang, Reichenberger, Frank, Niehaus, Christa, Herth, Felix, Eberhardt, Ralf, Gompelmann, Daniela, Rump, Brigitte, Darwiche, Kaid, Eisenmann, Stephan, Kaiser, Ulrike, Schwarz, Birte, Sampel, Ulrike, Schumann, Christian, Kaiser, Robert, Schumann-Stoiber, Kathryn, Skowasch, Dirk, Ring, Sabine, Pison, Christophe, Briault, Amandine, Arbib, Francois, Jondot, Marie, Perez, Thierry, Fournier, Clement, Matran, Regis, Catto, Michele, Bautin, Nathalie, De Broucker, Virginie, Willemin, Marie, Prevotat, Anne, Wemeau, Ludivine, Gicquello, Alice, Foulon, Morgane, Camara, Hasna, Deslee, Gaetan, Vallerand, Herve, Dury, Sandra, Gras, Delphine, Bonnaire-Verdier, Margaux, Kessler, Romain, Hirschi, Sandrine, Porzio, Michele, Degot, Tristan, Canuet, Mathieu, Schuller, Armelle, Stauder, Julien, Azouaou, Sahra Ali, Marceau, Armelle, Mal, Hervé, Costa, Yolande, Shah, Pallav L., Garner, Justin, Srikanthan, Karthi, Caneja, Cielito, Thornton, John, Slebos, Dirk-Jan, Hacken, Nick Ten, Hartman, Jorine, Klooster, Karin, Augustijn, Sonja, Bonta, Peter, Annema, Jouke, van de Pol, Marianne, Goorsenberg, Annika, Hartman, Jorine E., Herth, Felix J.F., and Shah, Pallav

Published
2023
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21. Mobilisation of HLA‐F on the surface of bronchial epithelial cells and platelets in asthmatic patients

Author

Fiouane, Sabrina, primary, Chebbo, Mohamad, additional, Beley, Sophie, additional, Paganini, Julien, additional, Picard, Christophe, additional, D'Journo, Xavier‐Benoît, additional, Thomas, Pascal‐Alexandre, additional, Chiaroni, Jacques, additional, Chanez, Pascal, additional, Gras, Delphine, additional, and Di Cristofaro, Julie, additional

Published
2022
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26. Diasporas, Cultures of Mobilities, ‘Race’ 3

Author

A. Reid, Mark, Duboin, Corinne, Gomez, Michael A., Gras, Delphine, H. A. Rushdy, Ashraf, Joyce Boyd, Melba, M. Wilks, Jennifer, Miller, D. Quentin, Morehouse, Maggi, Parent, Anthony, Pereira, Malin, Pierre, Alix, Raynaud, Claudine, Rice, Alan, Smyth, Heather, Veroni-Paccher, Lisa, Vogt-William, Christine, Duboin, Corinne, and Raynaud, Claudine

Subjects
African-American, diaspora noire, expatriation, afrique noire, post-blackness, Social Issues, post-raciality, internationalisme noir, études afro-américaines, African-American studies, African-American identity, Black Africa, Black internationalism, identité afro-américaine, identité noire, afro-américaine, Black diaspora, post-racialité, Black identity, JFFN, race, postblackness, SOC007000
Abstract

Reflet des débats actuels dans les champs croisés des Études afro-américaines et des Études diasporiques, ces essais critiques et études de cas explorent l’articulation entre les concepts fluctuants de « race » et de diaspora et les négociations des identités au-delà des différences. Ils étudient tour à tour l’évolution de l’(inter)nationalisme noir au sein de la Diaspora, les nouveaux discours sur la post-racialité et la notion de « postblackness », la conscience raciale chez les soldats afro-américains, l’expatriation et la re-diasporisation. Le constat d’un rejet de l’africanité au sein de sociétés telles que les Émirats, le Maroc ou la République dominicaine entre en relation avec les analyses d’œuvres d’art au prisme d’une conscience diasporique et de textes littéraires qui disent l’internationalisme ou subvertissent la notion de « race ». James Baldwin dialogue alors avec Percival Everett. Reflecting current debates in the intersecting fields of African American Studies and African Diaspora, these critical essays and case studies explore the articulation between the fluctuating concepts of ‘race’ and Diaspora and the negotiations of identities across differences. They examine in turn the developments of diasporic black (inter)nationalism, new discourses on ‘postraciality’ and ‘postblackness’, race consciousness among African American soldiers, expatriation and re-diasporization. The acknowledgement of a rejection of Africanness in societies such as the Emirates, Morocco or the Dominican Republic dialogues with examinations of artwork through the lenses of a diasporic consciousness and analyses of literary texts that celebrate internationalism or subvert the notion of ‘race’. James Baldwin thus converses with Percival Everett.

Published
2021

27. In the Steps of the Griots: Traveling Bards in Shay Youngblood’s Black Girl in Paris

Author

Gras, Delphine

Subjects
African-American, diaspora noire, expatriation, afrique noire, post-blackness, Social Issues, post-raciality, internationalisme noir, études afro-américaines, African-American studies, African-American identity, Black Africa, Black internationalism, identité afro-américaine, identité noire, afro-américaine, Black diaspora, post-racialité, Black identity, JFFN, race, postblackness, SOC007000
Abstract

This paper explores the figure of the griot in Shay Youngblood’s Black Girl in Paris (2000). More precisely, it traces how the protagonist Eden becomes an itinerant bard, historian, and exhorter who retraces Black Atlantic routes while proudly asserting her roots as member of the African Diaspora. Through her mental and physical journeys, the heroine creates cartographies of experience that seek to better express one’s feelings and grow as individual and as artist, attesting to the need to maintain a sense of imagined community to fight the lasting effects of racism as a global phenomenon, a discrimination that she feels doubly as a Black woman. Following her predecessors James Baldwin and Langston Hughes, the protagonist comes to embody a new generation of bards who encourage us to look at the past and learn not to declare too quickly a ‘post-race’ era. She represents a new generation of griots, those Jean Ouédraogo fits under the category of ‘griot novateur ou explorateur’ (86), because their roles go beyond upholding tradition and keeping a record of history. But while Ouédraogo focuses on works set in West Africa, I expand this definition to include writers like Youngblood who also carry on the legacy of the griots, their art outliving colonialism and slavery. In fact under the pen of a writer like Youngblood, who answers Amiri Baraka’s call to offer ‘what the Griot/Djali provided, information, inspiration, reformation, and self-determination’ (Suso 82), the griots’ art finds a new breath in the Americas.

Published
2021

28. Safety and Dose Study of Targeted Lung Denervation in Moderate/Severe COPD Patients

Author

Valipour, Arschang, Shah, Pallav L, Pison, Christophe, Ninane, Vincent, Janssens, Wim, Perez, Thierry, Kessler, Romain, Deslee, Gaetan, Garner, Justin, Abele, Christine, Hartman, Jorine E, Slebos, Dirk-Jan, Chen, A, Gorden, J, Issa, Z, McDonald, G, Pulling, C, Aalbers, R, Ferrera, D, Leh, L, Firlinger, Irene, Kothakuzhakal, Kiran, Duller, Marina, Muylle, Inge, Rummens, Peter, De Cock, Frederique, Dooms, Christophe, DeBent, Kristien, Briault, Amandine, Arbib, Francois, Jondot, Marie, Ferretti, Gilbert, Fournier, Clement, Matran, Regis, Catto, Michele, Bautin, Nathalie, De Broucker, Virginie, Willemin, Marie, Prevotat, Anne, Wemeau, Ludivine, Gicquello, Alice, Foulon, Morgane, Camara, Hasna, Vallerand, Herve, Dury, Sandra, Gras, Delphine, Bonnaire-Verdier, Margaux, Hirschi, Sandrine, Porzio, Michele, Degot, Tristan, Canuet, Mathieu, Schuller, Armelle, Stauder, Julien, Azouaou, Sahra Ali, Srikanthan, Karthi, Caneja, Cielito, Thornton, John, Ten Hacken, Nick, Hartman, Jorine, Augustijn, Sonja, Klooster, Karin, Groningen Research Institute for Asthma and COPD (GRIAC), Department of Respiratory and Critical Care Medicine, Ludwig-Boltzmann-Institute for COPD and Respiratory Epidemiology, Otto-Wagner-Spital, Vienna, Royal Brompton and Harefield NHS Trust, Chelsea and Westminster Hospital, and Imperial College, London, Centre Hospitalier Universitaire [Grenoble] (CHU), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), CHU Saint-Pierre, Université libre de Bruxelles, Bruxelles, Department of Respiratory Diseases, KU Leuven, University Hospitals Leuven, Leuven, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Service de Pneumologie, Nouvel Hôpital Civil, Université de Strasbourg, Strasbourg, Hôpital Maison Blanche, Centre Hospitalier Universitaire de Reims (CHU Reims), University Medical Center Groningen [Groningen] (UMCG), Imperial College London, Université libre de Bruxelles (ULB), Institut Pasteur de Lille, and Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Pulmonary and Respiratory Medicine, Male, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, law.invention, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Quality of life, Randomized controlled trial, law, Bronchoscopy, Parasympathectomy, medicine, Clinical endpoint, Humans, Interventional Pulmonology, 030212 general & internal medicine, Dosing, Adverse effect, Lung, Aged, COPD, business.industry, Radiofrequency ablation, Middle Aged, medicine.disease, Acetylcholine, 3. Good health, medicine.anatomical_structure, 030228 respiratory system, Anesthesia, Lung disease obstructive, Female, Pneumologie, Airway, business
Abstract

Rationale: Targeted lung denervation (TLD) is a novel bronchoscopic treatment for the disruption of parasympathetic innervation of the lungs. Objectives: To assess safety, feasibility, and dosing of TLD in patients with moderate to severe COPD using a novel device design. Methods: Thirty patients with COPD (forced expiratory volume in 1 s 30-60%) were 1:1 randomized in a double-blinded fashion to receive TLD with either 29 or 32 W. Primary endpoint was the rate of TLD-associated adverse airway effects that required treatment through 3 months. Assessments of lung function, quality of life, dyspnea, and exercise capacity were performed at baseline and 1-year follow-up. An additional 16 patients were enrolled in an open-label confirmation phase study to confirm safety improvements after procedural enhancements following gastrointestinal adverse events during the randomized part of the trial. Results: Procedural success, defined as device success without an in-hospital serious adverse event, was 96.7% (29/30). The rate of TLD-associated adverse airway effects requiring intervention was 3/15 in the 32 W versus 1/15 in the 29 W group, p = 0.6. Five patients early in the randomized phase experienced serious gastric events. The study was stopped and procedural changes made that reduced both gastrointestinal and airway events in the subsequent phase of the randomized trial and follow-up confirmation study. Improvements in lung function and quality of life were observed compared to baseline values for both doses but were not statistically different. Conclusions: The results demonstrate acceptable safety and feasibility of TLD in patients with COPD, with improvements in adverse event rates after procedural enhancements., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2019
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34. Thiazolidinediones induce proliferation of human bronchial epithelial cells through the GPR40 receptor

Author

Gras, Delphine, Chanez, Pascal, Urbach, Valerie, Vachier, Isabelle, Godard, Philippe, and Bonnans, Caroline

Subjects
Cell receptors -- Physiological aspects, Cell receptors -- Genetic aspects, Cell receptors -- Research, Cellular signal transduction -- Physiological aspects, Cellular signal transduction -- Research, Peroxisomes -- Physiological aspects, Peroxisomes -- Research, Thiazolidinediones -- Health aspects, Thiazolidinediones -- Research, Biological sciences
Abstract

Thiazolidinediones (TZDs) are synthetic peroxisome proliferator-activated receptor-[gamma] (PPAR[gamma]) ligands that are widely used in type II diabetes treatment. In addition to their ability to improve glucose homeostasis, TZDs possess antiinflammatory properties and inhibit growth of many cells, particularly cancerous airway epithelial cells. However, the functional effects of PPAR[gamma] ligands on nonmalignant human bronchial epithelial cells have never been investigated. In the present study, we questioned whether PPAR[gamma] ligands may regulate proliferation of human bronchial epithelial cells, and we studied their potential molecular mechanisms. We found that synthetic PPAR[gamma] agonists, rosiglitazone (RGZ) and troglitazone (TGZ), induced proliferation of human bronchial epithelial cells, whereas the endogenous PPAR[gamma], ligand, 15-deoxy-[[DELTA].sup.12,14]-prostaglandin [J.sub.2] (15d-[PGJ.sub.2]), inhibited cell growth. RGZ and TGZ (10 [micro]M) induced a rapid and transient intracellular [Ca.sup.2+] mobilization from thapsigargin-sensitive intracellular stores, whereas 15d-[PGJ.sub.2] (5 [micro]M) did not induce any [Ca.sup.2+] signal. The PPAR[gamma] antagonist GW-9662 did not inhibit any biological responses, but it reversed the effect of 15d-[PGJ.sub.2] on cell growth. Using RT-PCR, we detected mRNA expression of the GPR40 receptor, a G proteincoupled receptor recently identified as a receptor for free fatty acids and TZDs, in human bronchial epithelial cells. Downregulation of GPR40 by small-interfering RNA led to a significant inhibition of TZD-induced [Ca.sup.2+] mobilization and proliferation. This study provides evidence for the proliferative effect of anti-diabetic drug TZDs in nonmalignant human bronchial epithelial cells through GPR40 receptor activation, involving an intracellular [Ca.sup.2+] signaling pathway. airway epithelium; glitazone; calcium; peroxisome proliferator-activated receptor-[gamma]; G protein receptor 40

Published
2009

35. 'I'll Rise': rememory, hope and the creation of a new public sphere in Ben Harper's music

Author

Gras, Delphine

Subjects
Music, Black -- Social aspects -- Analysis, Music and morals -- Analysis -- Social aspects, Public sphere -- Management -- Analysis -- Social aspects, Musicians -- Works -- Social aspects -- Analysis, Company business management, Humanities
Abstract

Recent studies about resistance music in the United States primarily focus on the hip-hop movement. However, it does not offer the only musical discourse contesting contemporary injustices. Even though the [...]

Published
2008

36. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Author

Ziegler, Carly GK, Allon, Samuel J, Nyquist, Sarah K, Mbano, Ian M, Miao, Vincent N, Tzouanas, Constantine N, Cao, Yuming, Yousif, Ashraf S, Bals, Julia, Hauser, Blake M, Feldman, Jared, Muus, Christoph, Wadsworth, Marc H, Kazer, Samuel W, Hughes, Travis K, Doran, Benjamin, Gatter, G James, Vukovic, Marko, Taliaferro, Faith, Mead, Benjamin E, Guo, Zhiru, Wang, Jennifer P, Gras, Delphine, Plaisant, Magali, Ansari, Meshal, Angelidis, Ilias, Adler, Heiko, Sucre, Jennifer MS, Taylor, Chase J, Lin, Brian, Waghray, Avinash, Mitsialis, Vanessa, Dwyer, Daniel F, Buchheit, Kathleen M, Boyce, Joshua A, Barrett, Nora A, Laidlaw, Tanya M, Carroll, Shaina L, Colonna, Lucrezia, Tkachev, Victor, Peterson, Christopher W, Yu, Alison, Zheng, Hengqi Betty, Gideon, Hannah P, Winchell, Caylin G, Lin, Philana Ling, Bingle, Colin D, Snapper, Scott B, Kropski, Jonathan A, Theis, Fabian J, Schiller, Herbert B, Zaragosi, Laure-Emmanuelle, Barbry, Pascal, Leslie, Alasdair, Kiem, Hans-Peter, Flynn, JoAnne L, Fortune, Sarah M, Berger, Bonnie, Finberg, Robert W, Kean, Leslie S, Garber, Manuel, Schmidt, Aaron G, Lingwood, Daniel, Shalek, Alex K, Ordovas-Montanes, Jose, HCA Lung Biological Network. Electronic Address: Lung-Network@Humancellatlas.Org, HCA Lung Biological Network, Yousif, Ashraf S [0000-0001-9215-3853], Hauser, Blake M [0000-0002-0100-1684], Kazer, Samuel W [0000-0002-7380-9594], Sucre, Jennifer MS [0000-0002-6613-1439], Tkachev, Victor [0000-0001-6011-0576], Zheng, Hengqi Betty [0000-0003-0575-6475], Bingle, Colin D [0000-0002-5405-6988], and Apollo - University of Cambridge Repository

Subjects
Adolescent, Pneumonia, Viral, ACE2, non-human primate, HIV Infections, Peptidyl-Dipeptidase A, Cell Line, ISG, Betacoronavirus, Mice, scRNA-seq, Influenza, Human, Animals, Humans, Tuberculosis, human, Child, Lung, Pandemics, mouse, Cells, Cultured, SARS-CoV-2, Serine Endopeptidases, COVID-19, interferon, Mycobacterium tuberculosis, respiratory system, Macaca mulatta, Up-Regulation, Nasal Mucosa, Enterocytes, Alveolar Epithelial Cells, Interferon Type I, Receptors, Virus, Angiotensin-Converting Enzyme 2, Goblet Cells, Single-Cell Analysis, influenza, Coronavirus Infections
Abstract

There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-CoV-2 spike (S) protein binds angiotensin-converting enzyme 2 (ACE2), and in concert with host proteases, principally transmembrane serine protease 2 (TMPRSS2), promotes cellular entry. The cell subsets targeted by SARS-CoV-2 in host tissues and the factors that regulate ACE2 expression remain unknown. Here, we leverage human, non-human primate, and mouse single-cell RNA-sequencing (scRNA-seq) datasets across health and disease to uncover putative targets of SARS-CoV-2 among tissue-resident cell subsets. We identify ACE2 and TMPRSS2 co-expressing cells within lung type II pneumocytes, ileal absorptive enterocytes, and nasal goblet secretory cells. Strikingly, we discovered that ACE2 is a human interferon-stimulated gene (ISG) in vitro using airway epithelial cells and extend our findings to in vivo viral infections. Our data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.

Published
2020
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37. Tonnerre de Brest ! Des Journées de Recherche Respiratoires 2020 pas comme les autres…

Author

UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Annesi-Maesano, Isabella, Bonniaud, Philippe, Bouchaud, Grégory, Boyer, Laurent, Frossard, Nelly, Gazzeri, Sylvie, Gosset, Philippe, Gras, Delphine, Guibert, Christelle, Guignabert, Christophe, Mari, Bernard, Matécki, Stéfan, Morélot, Capucine, Pilette, Charles, Planes, Carole, Plantier, Laurent, Polette, Myriam, Si-Tahar, Mustapha, Taillé, Camille, Vachier, Isbelle, membres du comité J2R, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Annesi-Maesano, Isabella, Bonniaud, Philippe, Bouchaud, Grégory, Boyer, Laurent, Frossard, Nelly, Gazzeri, Sylvie, Gosset, Philippe, Gras, Delphine, Guibert, Christelle, Guignabert, Christophe, Mari, Bernard, Matécki, Stéfan, Morélot, Capucine, Pilette, Charles, Planes, Carole, Plantier, Laurent, Polette, Myriam, Si-Tahar, Mustapha, Taillé, Camille, Vachier, Isbelle, and membres du comité J2R

Abstract

[Tonnerre de Brest! 2020 Respiratory Research Days like no others…].

Published
2021

39. Black Girl in Paris

Author

Gras, Delphine

Subjects
Black Girl in Paris (Book) -- Youngblood, Shay, Black Girl in Paris (Novel) -- Book reviews, Books -- Book reviews, Ethnic, cultural, racial issues/studies, History
Abstract

Youngblood, Shay. Black Girl in Paris. New York: Riverhead Books, 2000. Black Girl in Paris by Shay Youngblood is a colorful literary jazz arrangement where the author's narrative improvisations transport [...]

Published
2005

40. Dynamic interaction between airway epithelial cells and Staphylococcus aureus

Author

da Silva, Mauricio C.A., Zahm, Jean-Marie, Gras, Delphine, Bajolet, Odile, Abely, Michel, Hinnrasky, Jocelyne, Milliot, Magali, de Assis, Maria Cristina, Hologne, Coralie, Bonnet, Noel, Merten, Marc, Plotkowski, Maria Cristina, and Puchelle, Edith

Subjects
Staphylococcus aureus -- Research, Staphylococcus aureus -- Physiological aspects, Epithelium -- Research, Epithelium -- Physiological aspects, Respiratory organs -- Research, Respiratory organs -- Physiological aspects, Cardiopulmonary system -- Research, Cardiopulmonary system -- Physiological aspects, Biological sciences
Abstract

Staphylococcus aureus is a major cause of pulmonary infection, particularly in cystic fibrosis (CF) patients. However, few aspects of the interplay between S. aureus and host airway epithelial cells have been investigated thus far. We investigated by videomicroscopy the time- and bacterial concentration-dependent ([10.sup.4], [10.sup.6], and [10.sup.8] CFU/ml) effect of S. aureus on adherence, internalization, and the associated damage of the airway epithelial cells. The balance between the secretion by S. aureus of the [alpha]-toxin virulence factor and by the airway cells of the antibacterial secretory leukoproteinase inhibitor (SLPI) was also analyzed. After 1 h of interaction, whatever the initial bacterial concentration, a low percentage of S. aureus ( videomicroscopy; secretory leukoproteinase inhibitor; [alpha]-toxin; airway cell damage; bacterial adherence and internalization

Published
2004

43. Will the asthma revolution fostered by biologics also benefit adult ICU patients?

Author

Bourdin, Arnaud, primary, Charriot, Jérémy, additional, Boissin, Clément, additional, Ahmed, Engi, additional, Suehs, Carey, additional, De Sevin, Arthur, additional, Volpato, Mathilde, additional, Pahus, Laurie, additional, Gras, Delphine, additional, Vachier, Isabelle, additional, Halimi, Laurence, additional, Hamerlijnck, Dominic, additional, and Chanez, Pascal, additional

Published
2020
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44. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

Author

Ziegler, Carly G.K., primary, Allon, Samuel J., additional, Nyquist, Sarah K., additional, Mbano, Ian M., additional, Miao, Vincent N., additional, Tzouanas, Constantine N., additional, Cao, Yuming, additional, Yousif, Ashraf S., additional, Bals, Julia, additional, Hauser, Blake M., additional, Feldman, Jared, additional, Muus, Christoph, additional, Wadsworth, Marc H., additional, Kazer, Samuel W., additional, Hughes, Travis K., additional, Doran, Benjamin, additional, Gatter, G. James, additional, Vukovic, Marko, additional, Taliaferro, Faith, additional, Mead, Benjamin E., additional, Guo, Zhiru, additional, Wang, Jennifer P., additional, Gras, Delphine, additional, Plaisant, Magali, additional, Ansari, Meshal, additional, Angelidis, Ilias, additional, Adler, Heiko, additional, Sucre, Jennifer M.S., additional, Taylor, Chase J., additional, Lin, Brian, additional, Waghray, Avinash, additional, Mitsialis, Vanessa, additional, Dwyer, Daniel F., additional, Buchheit, Kathleen M., additional, Boyce, Joshua A., additional, Barrett, Nora A., additional, Laidlaw, Tanya M., additional, Carroll, Shaina L., additional, Colonna, Lucrezia, additional, Tkachev, Victor, additional, Peterson, Christopher W., additional, Yu, Alison, additional, Zheng, Hengqi Betty, additional, Gideon, Hannah P., additional, Winchell, Caylin G., additional, Lin, Philana Ling, additional, Bingle, Colin D., additional, Snapper, Scott B., additional, Kropski, Jonathan A., additional, Theis, Fabian J., additional, Schiller, Herbert B., additional, Zaragosi, Laure-Emmanuelle, additional, Barbry, Pascal, additional, Leslie, Alasdair, additional, Kiem, Hans-Peter, additional, Flynn, JoAnne L., additional, Fortune, Sarah M., additional, Berger, Bonnie, additional, Finberg, Robert W., additional, Kean, Leslie S., additional, Garber, Manuel, additional, Schmidt, Aaron G., additional, Lingwood, Daniel, additional, Shalek, Alex K., additional, Ordovas-Montanes, Jose, additional, Banovich, Nicholas, additional, Brazma, Alvis, additional, Desai, Tushar, additional, Duong, Thu Elizabeth, additional, Eickelberg, Oliver, additional, Falk, Christine, additional, Farzan, Michael, additional, Glass, Ian, additional, Haniffa, Muzlifah, additional, Horvath, Peter, additional, Hung, Deborah, additional, Kaminski, Naftali, additional, Krasnow, Mark, additional, Kuhnemund, Malte, additional, Lafyatis, Robert, additional, Lee, Haeock, additional, Leroy, Sylvie, additional, Linnarson, Sten, additional, Lundeberg, Joakim, additional, Meyer, Kerstin, additional, Misharin, Alexander, additional, Nawijn, Martijn, additional, Nikolic, Marko Z., additional, Pe’er, Dana, additional, Powell, Joseph, additional, Quake, Stephen, additional, Rajagopal, Jay, additional, Tata, Purushothama Rao, additional, Rawlins, Emma L., additional, Regev, Aviv, additional, Reyfman, Paul A., additional, Rojas, Mauricio, additional, Rosen, Orit, additional, Saeb-Parsy, Kourosh, additional, Samakovlis, Christos, additional, Schiller, Herbert, additional, Schultze, Joachim L., additional, Seibold, Max A., additional, Shepherd, Douglas, additional, Spence, Jason, additional, Spira, Avrum, additional, Sun, Xin, additional, Teichmann, Sarah, additional, Theis, Fabian, additional, Tsankov, Alexander, additional, van den Berge, Maarten, additional, von Papen, Michael, additional, Whitsett, Jeffrey, additional, Xavier, Ramnik, additional, Xu, Yan, additional, and Zhang, Kun, additional

Published
2020
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45. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues

Author

Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Koch Institute for Integrative Cancer Research at MIT, Ziegler, Carly G.K., Allon, Samuel J., Nyquist, Sarah K., Mbano, Ian M., Miao, Vincent N., Tzouanas, Constantine N., Cao, Yuming, Yousif, Ashraf S., Bals, Julia, Hauser, Blake M., Feldman, Jared, Muus, Christoph, Wadsworth, Marc H., Kazer, Samuel W., Hughes, Travis K., Doran, Benjamin, Gatter, G. James, Vukovic, Marko, Taliaferro, Faith, Mead, Benjamin E., Guo, Zhiru, Wang, Jennifer P., Gras, Delphine, Plaisant, Magali, Ansari, Meshal, Angelidis, Ilias, Adler, Heiko, Sucre, Jennifer M.S., Taylor, Chase J., Lin, Brian, Waghray, Avinash, Mitsialis, Vanessa, Dwyer, Daniel F., Buchheit, Kathleen M., Boyce, Joshua A., Barrett, Nora A., Laidlaw, Tanya M., Carroll, Shaina L., Colonna, Lucrezia, Tkachev, Victor, Peterson, Christopher W., Yu, Alison, Zheng, Hengqi Betty, Gideon, Hannah P., Winchell, Caylin G., Lin, Philana Ling, Bingle, Colin D., Snapper, Scott B., Kropski, Jonathan A., Theis, Fabian J., Schiller, Herbert B., Zaragosi, Laure-Emmanuelle, Barbry, Pascal, Leslie, Alasdair, Kiem, Hans-Peter, Flynn, JoAnne L., Fortune, Sarah M., Berger, Bonnie, Finberg, Robert W., Kean, Leslie S., Garber, Manuel, Schmidt, Aaron G., Lingwood, Daniel, Shalek, Alex K., Ordovas-Montanes, Jose, Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Koch Institute for Integrative Cancer Research at MIT, Ziegler, Carly G.K., Allon, Samuel J., Nyquist, Sarah K., Mbano, Ian M., Miao, Vincent N., Tzouanas, Constantine N., Cao, Yuming, Yousif, Ashraf S., Bals, Julia, Hauser, Blake M., Feldman, Jared, Muus, Christoph, Wadsworth, Marc H., Kazer, Samuel W., Hughes, Travis K., Doran, Benjamin, Gatter, G. James, Vukovic, Marko, Taliaferro, Faith, Mead, Benjamin E., Guo, Zhiru, Wang, Jennifer P., Gras, Delphine, Plaisant, Magali, Ansari, Meshal, Angelidis, Ilias, Adler, Heiko, Sucre, Jennifer M.S., Taylor, Chase J., Lin, Brian, Waghray, Avinash, Mitsialis, Vanessa, Dwyer, Daniel F., Buchheit, Kathleen M., Boyce, Joshua A., Barrett, Nora A., Laidlaw, Tanya M., Carroll, Shaina L., Colonna, Lucrezia, Tkachev, Victor, Peterson, Christopher W., Yu, Alison, Zheng, Hengqi Betty, Gideon, Hannah P., Winchell, Caylin G., Lin, Philana Ling, Bingle, Colin D., Snapper, Scott B., Kropski, Jonathan A., Theis, Fabian J., Schiller, Herbert B., Zaragosi, Laure-Emmanuelle, Barbry, Pascal, Leslie, Alasdair, Kiem, Hans-Peter, Flynn, JoAnne L., Fortune, Sarah M., Berger, Bonnie, Finberg, Robert W., Kean, Leslie S., Garber, Manuel, Schmidt, Aaron G., Lingwood, Daniel, Shalek, Alex K., and Ordovas-Montanes, Jose

Abstract

There is pressing urgency to understand the pathogenesis of the severe acute respiratory syndrome coronavirus clade 2 (SARS-CoV-2) which causes the disease COVID-19. SARSCoV- 2 spike (S)-protein binds ACE2, and in concert with host proteases, principally TMPRSS2, promotes cellular entry. The cell subsets targeted by SARS-CoV-2 in host tissues, and the factors that regulate ACE2 expression, remain unknown. Here, we leverage human, non-human primate, and mouse single-cell RNA-sequencing (scRNA-seq) datasets across health and disease to uncover putative targets of SARS-CoV-2 amongst tissue-resident cell subsets. We identify ACE2 and TMPRSS2 co-expressing cells within lung type II pneumocytes, ileal absorptive enterocytes, and nasal goblet secretory cells. Strikingly, we discover that ACE2 is a human interferon-stimulated gene (ISG) in vitro using airway epithelial cells, and extend our findings to in vivo viral infections. Our data suggest that SARS-CoV-2 could exploit speciesspecific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.

Published
2020

46. HLA-H: Transcriptional Activity and HLA-E Mobilization

Author

Jordier, François, primary, Gras, Delphine, additional, De Grandis, Maria, additional, D'Journo, Xavier-Benoît, additional, Thomas, Pascal-Alexandre, additional, Chanez, Pascal, additional, Picard, Christophe, additional, Chiaroni, Jacques, additional, Paganini, Julien, additional, and Di Cristofaro, Julie, additional

Published
2020
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47. Safety and Adverse Events after Targeted Lung Denervation for Symptomatic Moderate to Severe Chronic Obstructive Pulmonary Disease (AIRFLOW). A Multicenter Randomized Controlled Clinical Trial

Author

Slebos, Dirk-Jan, primary, Shah, Pallav L., additional, Herth, Felix J. F., additional, Pison, Christophe, additional, Schumann, Christian, additional, Hübner, Ralf-Harto, additional, Bonta, Peter I., additional, Kessler, Romain, additional, Gesierich, Wolfgang, additional, Darwiche, Kaid, additional, Lamprecht, Bernd, additional, Perez, Thierry, additional, Skowasch, Dirk, additional, Deslee, Gaetan, additional, Marceau, Armelle, additional, Sciurba, Frank C., additional, Gosens, Reinoud, additional, Hartman, Jorine E., additional, Srikanthan, Karthi, additional, Duller, Marina, additional, Valipour, Arschang, additional, Abele, Christine, additional, Firlinger, Irene, additional, Kothakuzhakal, Kiran, additional, Kropfmueller, Roland, additional, Holzmann, Kornelia, additional, Rathmeier, Sandra, additional, Hubner, Ralf, additional, Erdmann, Leonore, additional, Temmesfeld-Wollbrück, Bettina, additional, Glösenkamp, Christoph Ruwwe, additional, Reichenberger, Frank, additional, Niehaus, Christa, additional, Herth, Felix, additional, Eberhardt, Ralf, additional, Gompelmann, Daniela, additional, Rump, Brigitte, additional, Eisenmann, Stephan, additional, Kaiser, Ulrike, additional, Schwarz, Birte, additional, Sampel, Ulrike, additional, Kaiser, Robert, additional, Schumann-Stoiber, Kathryn, additional, Ring, Sabine, additional, Briault, Amandine, additional, Arbib, Francois, additional, Jondot, Marie, additional, Fournier, Clement, additional, Matran, Regis, additional, Catto, Michele, additional, Bautin, Nathalie, additional, De Broucker, Virginie, additional, Willemin, Marie, additional, Prevotat, Anne, additional, Wemeau, Ludivine, additional, Gicquello, Alice, additional, Foulon, Morgane, additional, Camara, Hasna, additional, Vallerand, Herve, additional, Dury, Sandra, additional, Gras, Delphine, additional, Bonnaire-Verdier, Margaux, additional, Hirschi, Sandrine, additional, Porzio, Michele, additional, Degot, Tristan, additional, Canuet, Mathieu, additional, Schuller, Armelle, additional, Stauder, Julien, additional, Azouaou, Sahra Ali, additional, Mal, Hervé, additional, Costa, Yolande, additional, Garner, Justin, additional, Caneja, Cielito, additional, Thornton, John, additional, Slebos, Dirk-Jan, additional, Ten Hacken, Nick, additional, Hartman, Jorine, additional, Klooster, Karin, additional, Augustijn, Sonja, additional, Bonta, Peter, additional, Annema, Jouke, additional, van de Pol, Marianne, additional, and Goorsenberg, Annika, additional

Published
2019
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50. Bronchial Epithelial Calcium Metabolism Impairment in Smokers and Chronic Obstructive Pulmonary Disease. Decreased ORAI3 Signaling

Author

Petit, Aurelie, primary, Knabe, Lucie, additional, Khelloufi, Kamel, additional, Jory, Myriam, additional, Gras, Delphine, additional, Cabon, Yann, additional, Begg, Malcolm, additional, Richard, Sylvain, additional, Massiera, Gladys, additional, Chanez, Pascal, additional, Vachier, Isabelle, additional, and Bourdin, Arnaud, additional

Published
2019
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