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1. First production of X-rays at the ThomX high-intensity Compton source

Author

Jacquet, M, Alexandre, P, Alkadi, M, Alves, M, Amer, M, Amoudry, L, Auguste, D, Babigeon, J, Balcou, P, Baltazar, M, Benabderrahmane, C, el Fekih, R, Benoit, A, Berteaud, P, Biagini, M, Blin, A, Bobault, S, Bonanzingamarco, M, Bonenfant, J, Bonis, J, Bouanani, Y, Bouaziz, S, Bouvet, F, Bravin, A, Bruni, C, Bruyere, C, Bzyl, H, Cassinari, L, Cassou, K, Cayla, J, Chabaud, T, Chaikovska, I, Chance, S, Chapelle, C, Chaumat, V, Chiche, R, Cobessi, A, Cormier, E, Cornebise, P, Couprie, M, Cuoq, R, Dalifard, O, Degallaix, J, Delerue, N, Del Net, W, Diaz, A, Dietrich, Y, Diop, M, Dorkel, R, Douillet, D, Drebot, I, Dugal, J, Dupraz, K, Dupuy, E, El Ajjouri, M, El Kamchi, N, El Khaldi, M, Elleaume, H, Ergenlik, E, Estève, F, Favier, P, Fernandez, M, Gamelin, A, Garaut, J, Garolfi, L, Gauron, P, Gauthier, F, Girault, P, Gonnin, A, Grasset, D, Guerard, E, Guler, H, Haissinski, J, Hazemann, J, Helder, D, Herbeaux, C, Herry, E, Hodeau, J, Horodynski, J, Hubert, N, Iaquaniello, G, Jacquet, P, Jeantet, P, Jehanno, D, Jules, E, Kapoujyan, G, Kubytskyi, V, Labat, M, Labaye, F, Lacipière, J, Lacroix, M, Lahéra, E, Langlet, M, Lebarillec, T, Ledu, J, Le Duc, G, Le Guidec, D, Leluan, B, Lepercq, P, Lestrade, A, Jacquet M., Alexandre P., Alkadi M., Alves M., Amer M., Amoudry L., Auguste D., Babigeon J. L., Balcou P., Baltazar M., Benabderrahmane C., el Fekih R. B., Benoit A., Berteaud P., Biagini M., Blin A., Bobault S., Bonanzingamarco M., Bonenfant J., Bonis J., Bouanani Y., Bouaziz S., Bouvet F., Bravin A., Bruni C., Bruyere C., Bzyl H., Cassinari L., Cassou K., Cayla J. N., Chabaud T., Chaikovska I., Chance S., Chapelle C., Chaumat V., Chiche R., Cobessi A., Cormier E., Cornebise P., Couprie M. E., Cuoq R., Dalifard O., Degallaix J., Delerue N., Del Net W., Diaz A., Dietrich Y., Diop M., Dorkel R., Douillet D., Drebot I., Dugal J. P., Dupraz K., Dupuy E., El Ajjouri M., El Kamchi N., El Khaldi M., Elleaume H., Ergenlik E., Estève F., Favier P., Fernandez M., Gamelin A., Garaut J. F., Garolfi L., Gauron P., Gauthier F., Girault P., Gonnin A., Grasset D., Guerard E., Guler H., Haissinski J., Hazemann J. L., Helder D., Herbeaux C., Herry E., Hodeau J. L., Horodynski J. M., Hubert N., Iaquaniello G., Jacquet P., Jeantet P., Jehanno D., Jules E., Kapoujyan G., Kubytskyi V., Labat M., Labaye F., Lacipière J., Lacroix M., Lahéra E., Langlet M., Lebarillec T., Ledu J. F., Le Duc G., Le Guidec D., Leluan B., Lepercq P., Lestrade A., Jacquet, M, Alexandre, P, Alkadi, M, Alves, M, Amer, M, Amoudry, L, Auguste, D, Babigeon, J, Balcou, P, Baltazar, M, Benabderrahmane, C, el Fekih, R, Benoit, A, Berteaud, P, Biagini, M, Blin, A, Bobault, S, Bonanzingamarco, M, Bonenfant, J, Bonis, J, Bouanani, Y, Bouaziz, S, Bouvet, F, Bravin, A, Bruni, C, Bruyere, C, Bzyl, H, Cassinari, L, Cassou, K, Cayla, J, Chabaud, T, Chaikovska, I, Chance, S, Chapelle, C, Chaumat, V, Chiche, R, Cobessi, A, Cormier, E, Cornebise, P, Couprie, M, Cuoq, R, Dalifard, O, Degallaix, J, Delerue, N, Del Net, W, Diaz, A, Dietrich, Y, Diop, M, Dorkel, R, Douillet, D, Drebot, I, Dugal, J, Dupraz, K, Dupuy, E, El Ajjouri, M, El Kamchi, N, El Khaldi, M, Elleaume, H, Ergenlik, E, Estève, F, Favier, P, Fernandez, M, Gamelin, A, Garaut, J, Garolfi, L, Gauron, P, Gauthier, F, Girault, P, Gonnin, A, Grasset, D, Guerard, E, Guler, H, Haissinski, J, Hazemann, J, Helder, D, Herbeaux, C, Herry, E, Hodeau, J, Horodynski, J, Hubert, N, Iaquaniello, G, Jacquet, P, Jeantet, P, Jehanno, D, Jules, E, Kapoujyan, G, Kubytskyi, V, Labat, M, Labaye, F, Lacipière, J, Lacroix, M, Lahéra, E, Langlet, M, Lebarillec, T, Ledu, J, Le Duc, G, Le Guidec, D, Leluan, B, Lepercq, P, Lestrade, A, Jacquet M., Alexandre P., Alkadi M., Alves M., Amer M., Amoudry L., Auguste D., Babigeon J. L., Balcou P., Baltazar M., Benabderrahmane C., el Fekih R. B., Benoit A., Berteaud P., Biagini M., Blin A., Bobault S., Bonanzingamarco M., Bonenfant J., Bonis J., Bouanani Y., Bouaziz S., Bouvet F., Bravin A., Bruni C., Bruyere C., Bzyl H., Cassinari L., Cassou K., Cayla J. N., Chabaud T., Chaikovska I., Chance S., Chapelle C., Chaumat V., Chiche R., Cobessi A., Cormier E., Cornebise P., Couprie M. E., Cuoq R., Dalifard O., Degallaix J., Delerue N., Del Net W., Diaz A., Dietrich Y., Diop M., Dorkel R., Douillet D., Drebot I., Dugal J. P., Dupraz K., Dupuy E., El Ajjouri M., El Kamchi N., El Khaldi M., Elleaume H., Ergenlik E., Estève F., Favier P., Fernandez M., Gamelin A., Garaut J. F., Garolfi L., Gauron P., Gauthier F., Girault P., Gonnin A., Grasset D., Guerard E., Guler H., Haissinski J., Hazemann J. L., Helder D., Herbeaux C., Herry E., Hodeau J. L., Horodynski J. M., Hubert N., Iaquaniello G., Jacquet P., Jeantet P., Jehanno D., Jules E., Kapoujyan G., Kubytskyi V., Labat M., Labaye F., Lacipière J., Lacroix M., Lahéra E., Langlet M., Lebarillec T., Ledu J. F., Le Duc G., Le Guidec D., Leluan B., Lepercq P., and Lestrade A.

Abstract

With the increase in laser power and finesse of optical cavities over the last decade, laboratory-size Compton sources are very promising. These sources produce X-rays through interactions between relativistic electrons and laser photons and, in term of brightness, fall between large synchrotron facilities and classical laboratory X-ray sources. The ThomX source is the French project in this field. This article first presents a state of the art of high-intensity Compton sources, then the ThomX source is briefly described, and the first results are detailed, in particular the production of the first X-rays, the acquisition of the first spectrum and the first image of the beam. Finally, the next objectives are discussed.

Published
2024

2. The ThomX ICS source

Author

Dupraz, K, Alkadi, M, Alves, M, Amoudry, L, Auguste, D, Babigeon, J, Baltazar, M, Benoit, A, Bonis, J, Bonenfant, J, Bruni, C, Cassou, K, Cayla, J, Chabaud, T, Chaikovska, I, Chance, S, Chaumat, V, Chiche, R, Cobessi, A, Cornebise, P, Dalifard, O, Delerue, N, Dorkel, R, Douillet, D, Dugal, J, El Kamchi, N, El Khaldi, M, Ergenlik, E, Favier, P, Fernandez, M, Gamelin, A, Garaut, J, Garolfi, L, Gauron, P, Gauthier, F, Gonnin, A, Grasset, D, Guerard, E, Guler, H, Haissinski, J, Herry, E, Iaquaniello, G, Jacquet, M, Jules, E, Kubytskyi, V, Langlet, M, Le Barillec, T, Ledu, J, Leguidec, D, Leluan, B, Lepercq, P, Letellier-Cohen, F, Marie, R, Marrucho, J, Martens, A, Mageur, C, Mercadier, G, Mercier, B, Mistretta, E, Monard, H, Moutardier, A, Neveu, O, Nutarelli, D, Omeich, M, Peinaud, Y, Petrilli, Y, Pichet, M, Plaige, E, Prevost, C, Rudnicky, P, Soskov, V, Taurigna-Quere, M, Trochet, S, Vallerand, C, Vitez, O, Wicek, F, Wurth, S, Zomer, F, Alexandre, P, Ben El Fekih, R, Berteaud, P, Bouvet, F, Cuoq, R, Diaz, A, Dietrich, Y, Diop, M, Pedeau, D, Dupuy, E, Marteau, F, Helder, D, Hubert, N, Veteran, J, Labat, M, Lestrade, A, Letresor, A, Lopes, R, Loulergue, A, Louvet, M, Marchand, P, El Ajjouri, M, Muller, D, Nadji, A, Nadolski, L, Nagaoka, R, Petit, S, Pollina, J, Ribeiro, F, Ros, M, Salvia, J, Bobault, S, Sebdaoui, M, Sreedharan, R, Bouanai, Y, Hazemann, J, Hodeau, J, Roy, E, Jeantet, P, Lacipiere, J, Robert, P, Horodynski, J, Bzyl, H, Chapelle, C, Biagini, M, Walter, P, Bravin, A, Del Net, W, Lahera, E, Proux, O, Elleaume, H, Cormier, E, Dupraz K., Alkadi M., Alves M., Amoudry L., Auguste D., Babigeon J. -L., Baltazar M., Benoit A., Bonis J., Bonenfant J., Bruni C., Cassou K., Cayla J. -N., Chabaud T., Chaikovska I., Chance S., Chaumat V., Chiche R., Cobessi A., Cornebise P., Dalifard O., Delerue N., Dorkel R., Douillet D., Dugal J. -P., El Kamchi N., El Khaldi M., Ergenlik E., Favier P., Fernandez M., Gamelin A., Garaut J. -F., Garolfi L., Gauron P., Gauthier F., Gonnin A., Grasset D., Guerard E., Guler H., Haissinski J., Herry E., Iaquaniello G., Jacquet M., Jules E., Kubytskyi V., Langlet M., Le Barillec T., Ledu J. -F., Leguidec D., Leluan B., Lepercq P., Letellier-Cohen F., Marie R., Marrucho J. -C., Martens A., Mageur C., Mercadier G., Mercier B., Mistretta E., Monard H., Moutardier A., Neveu O., Nutarelli D., Omeich M., Peinaud Y., Petrilli Y., Pichet M., Plaige E., Prevost C., Rudnicky P., Soskov V., Taurigna-Quere M., Trochet S., Vallerand C., Vitez O., Wicek F., Wurth S., Zomer F., Alexandre P., Ben El Fekih R., Berteaud P., Bouvet F., Cuoq R., Diaz A., Dietrich Y., Diop M., Pedeau D., Dupuy E., Marteau F., Helder D., Hubert N., Veteran J., Labat M., Lestrade A., Letresor A., Lopes R., Loulergue A., Louvet M., Marchand P., El Ajjouri M., Muller D., Nadji A., Nadolski L., Nagaoka R., Petit S., Pollina J. -P., Ribeiro F., Ros M., Salvia J., Bobault S., Sebdaoui M., Sreedharan R., Bouanai Y., Hazemann J. -L., Hodeau J. -L., Roy E., Jeantet P., Lacipiere J., Robert P., Horodynski J. -M., Bzyl H., Chapelle C., Biagini M., Walter P., Bravin A., Del Net W., Lahera E., Proux O., Elleaume H., Cormier E., Dupraz, K, Alkadi, M, Alves, M, Amoudry, L, Auguste, D, Babigeon, J, Baltazar, M, Benoit, A, Bonis, J, Bonenfant, J, Bruni, C, Cassou, K, Cayla, J, Chabaud, T, Chaikovska, I, Chance, S, Chaumat, V, Chiche, R, Cobessi, A, Cornebise, P, Dalifard, O, Delerue, N, Dorkel, R, Douillet, D, Dugal, J, El Kamchi, N, El Khaldi, M, Ergenlik, E, Favier, P, Fernandez, M, Gamelin, A, Garaut, J, Garolfi, L, Gauron, P, Gauthier, F, Gonnin, A, Grasset, D, Guerard, E, Guler, H, Haissinski, J, Herry, E, Iaquaniello, G, Jacquet, M, Jules, E, Kubytskyi, V, Langlet, M, Le Barillec, T, Ledu, J, Leguidec, D, Leluan, B, Lepercq, P, Letellier-Cohen, F, Marie, R, Marrucho, J, Martens, A, Mageur, C, Mercadier, G, Mercier, B, Mistretta, E, Monard, H, Moutardier, A, Neveu, O, Nutarelli, D, Omeich, M, Peinaud, Y, Petrilli, Y, Pichet, M, Plaige, E, Prevost, C, Rudnicky, P, Soskov, V, Taurigna-Quere, M, Trochet, S, Vallerand, C, Vitez, O, Wicek, F, Wurth, S, Zomer, F, Alexandre, P, Ben El Fekih, R, Berteaud, P, Bouvet, F, Cuoq, R, Diaz, A, Dietrich, Y, Diop, M, Pedeau, D, Dupuy, E, Marteau, F, Helder, D, Hubert, N, Veteran, J, Labat, M, Lestrade, A, Letresor, A, Lopes, R, Loulergue, A, Louvet, M, Marchand, P, El Ajjouri, M, Muller, D, Nadji, A, Nadolski, L, Nagaoka, R, Petit, S, Pollina, J, Ribeiro, F, Ros, M, Salvia, J, Bobault, S, Sebdaoui, M, Sreedharan, R, Bouanai, Y, Hazemann, J, Hodeau, J, Roy, E, Jeantet, P, Lacipiere, J, Robert, P, Horodynski, J, Bzyl, H, Chapelle, C, Biagini, M, Walter, P, Bravin, A, Del Net, W, Lahera, E, Proux, O, Elleaume, H, Cormier, E, Dupraz K., Alkadi M., Alves M., Amoudry L., Auguste D., Babigeon J. -L., Baltazar M., Benoit A., Bonis J., Bonenfant J., Bruni C., Cassou K., Cayla J. -N., Chabaud T., Chaikovska I., Chance S., Chaumat V., Chiche R., Cobessi A., Cornebise P., Dalifard O., Delerue N., Dorkel R., Douillet D., Dugal J. -P., El Kamchi N., El Khaldi M., Ergenlik E., Favier P., Fernandez M., Gamelin A., Garaut J. -F., Garolfi L., Gauron P., Gauthier F., Gonnin A., Grasset D., Guerard E., Guler H., Haissinski J., Herry E., Iaquaniello G., Jacquet M., Jules E., Kubytskyi V., Langlet M., Le Barillec T., Ledu J. -F., Leguidec D., Leluan B., Lepercq P., Letellier-Cohen F., Marie R., Marrucho J. -C., Martens A., Mageur C., Mercadier G., Mercier B., Mistretta E., Monard H., Moutardier A., Neveu O., Nutarelli D., Omeich M., Peinaud Y., Petrilli Y., Pichet M., Plaige E., Prevost C., Rudnicky P., Soskov V., Taurigna-Quere M., Trochet S., Vallerand C., Vitez O., Wicek F., Wurth S., Zomer F., Alexandre P., Ben El Fekih R., Berteaud P., Bouvet F., Cuoq R., Diaz A., Dietrich Y., Diop M., Pedeau D., Dupuy E., Marteau F., Helder D., Hubert N., Veteran J., Labat M., Lestrade A., Letresor A., Lopes R., Loulergue A., Louvet M., Marchand P., El Ajjouri M., Muller D., Nadji A., Nadolski L., Nagaoka R., Petit S., Pollina J. -P., Ribeiro F., Ros M., Salvia J., Bobault S., Sebdaoui M., Sreedharan R., Bouanai Y., Hazemann J. -L., Hodeau J. -L., Roy E., Jeantet P., Lacipiere J., Robert P., Horodynski J. -M., Bzyl H., Chapelle C., Biagini M., Walter P., Bravin A., Del Net W., Lahera E., Proux O., Elleaume H., and Cormier E.

Abstract

ThomX is a new generation Compact Compton Source. It is currently commissioned by and at the IJCLab (Laboratoire de physique des 2 infinis - Irène Joliot-Curie (UMR9012)) at Orsay. The first beam is expected at the begining of 2021. The aim of ThomX is to demonstrate the characteristics of an intense and Compact (lab-size) X-ray source based on Compton Scattering. The performances are mostly driven by the laser optical system which is above the state of the art of stored laser power. Proof of principle of various X-ray techniques will be performed thanks to the versatile ThomX beamline. Firstly, this article presents the machine description. Secondly, the issues and limits of the laser system are discussed. Then, the ThomX beamline is described and the machine status conclude the ThomX presentation. Finally, the expected performances for the next years and the possible experiments that can be made with this new machine are detailed.

Published
2020

3. Evaluation in usual practice of the bevacizumab-FOLFIRI combination for the first-line treatment of patients with unresectable metastatic colorectal cancer treated in 2006: focus on resected patients and oncogeriatrics: AVASTIN OUEST cohort of the Observatory of Cancer of the Brittany and Pays de la Loire Areas (Observatoire dédié au Cancer Bretagne / Pays de la Loire)

Author

Metges, J. P., Lebot, M. A., Faroux, R., Riaud, F., Gamelin, E., Capitain, O., Guérin Meyer, V., Leynia, P., Douillard, J. Y., Senellart, H., Rochard, S., Louvigné, C., Campion, L., Dupuis, O., Grollier, C., Achour, N. A., Person, B., Raoul, J. L., Boucher, E., Bertrand, C., Ramée, J. F., Guivarch, L., Etienne, P. L., Roussel, S., Desclos, H., Julien, M. N., Labarre, M. I., Klein, V., Bessard, R., Stampfli, C., Royet, F., Faycal, J., Gouva, S., Le Bihan, G., Couturier, M., Gourlaouen, A., Bertholom, C., Porneuf, M., Jobard, E., Peguet, E., Grasset, D., Bouret, J. F., Bicheler, V., Ulvoas, A., Miglianico, L., Chouzenoux, C., Deguiral, P., Derenne, L., Martin, D., Langlet, P. Michel, Bodin, C., Rossi, V., Barré, S., Cojocarasu, O., Naveau Ploux, C., Vidal, A. M., Cumin, I., Egreteau, J., Brouard, A., Matysiak Budnik, T., Thomaré, P., Le Bris Michel, A. S., Piriou, G., Largeau, R., Elhannani, C., Crespeau, E., Suberville, F., Bourgeois, H., Riche, C., Lagadec, D. Déniel, Marhuenda, F., and Grudé, F.

Published
2014
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7. Etude prospective observationnelle multicentrique des hémorragies digestives hautes en centres hospitaliers généraux en 2017 – 2018, résultats à 6 mois

Author

Quentin, V, additional, Rémy, AJ, additional, Macaigne, G, additional, Leblanc-Boubchir, R, additional, Koudougou, C, additional, Prieto, M, additional, Tsakiris, L, additional, Grasset, D, additional, Cuen, D, additional, Elriz, K, additional, Verlynde, J, additional, Ripault, MP, additional, Baconnier, M, additional, Herrmann, S, additional, Vitte, RL, additional, Arpurt, JP, additional, Bideau, K, additional, Skinazi, F, additional, Lam, YH, additional, Costes, L, additional, Pelaquier, A, additional, Lahmek, P, additional, and Nahon, S, additional

Published
2019
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10. Impact of the hypermuscularity GDF8 gene on sheep maternal abilities traits

Author

François, Dominique, Carpentier, David, Bourdillon, Yves, Grasset, D., Tortereau, Flavie, Raoul, Jérôme, Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Domaine expérimental Bourges-La Sapinière (BOURGES), Institut National de la Recherche Agronomique (INRA), Groupe Inter-académique pour le Développement, Partenaires INRAE, Institut de l'élevage (IDELE), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], sheep, [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], [INFO] Computer Science [cs], genetic, hypermuscularity, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

11. Le gène d'hypertrophie musculaire du 'Texel Belge' : identification, impact, introgression

Author

Grasset, D., Bouix, Jacques, Bibé, Bernard, Levéziel, Hubert, Georges, Mathias, Laville, Elisabeth, Lauras, Groupement des Eleveurs de Brebis du Bassin de Roquefort (GEBRO), Station d'Amélioration Génétique des Animaux (SAGA), Institut National de la Recherche Agronomique (INRA), Unité de Génétique Moléculaire Animale (UGMA), Université de Limoges (UNILIM)-Institut National de la Recherche Agronomique (INRA), Université de Liège, Qualité des Produits Animaux (QuaPA), Unité de Génétique Moléculaire Animale (UMR GMA), and Institut National de la Recherche Agronomique (INRA)-Université de Limoges (UNILIM)

Subjects
GENE HYPERTROPHIE MUSCULAIRE, [SDV]Life Sciences [q-bio], TEXEL BELGE
Abstract

absent

Published
2009

12. Évaluation en pratique courante de l’association bevacizumab-FOLFIRI en première ligne chez des patients atteints d’un cancer colorectal métastatique non résécable traités en 2006: focus sur patients réséqués et oncogériatrie

Author

Metges, J. P., primary, Lebot, M. A., additional, Faroux, R., additional, Riaud, F., additional, Gamelin, E., additional, Capitain, O., additional, Guérin Meyer, V., additional, Leynia, P., additional, Douillard, J. Y., additional, Senellart, H., additional, Rochard, S., additional, Louvigné, C., additional, Campion, L., additional, Dupuis, O., additional, Grollier, C., additional, Achour, N. A., additional, Person, B., additional, Raoul, J. L., additional, Boucher, E., additional, Bertrand, C., additional, Ramée, J. F., additional, Guivarch, L., additional, Etienne, P. L., additional, Roussel, S., additional, Desclos, H., additional, Julien, M. N., additional, Labarre, M. I., additional, Klein, V., additional, Bessard, R., additional, Stampfli, C., additional, Royet, F., additional, Faycal, J., additional, Gouva, S., additional, Le Bihan, G., additional, Couturier, M., additional, Gourlaouen, A., additional, Bertholom, C., additional, Porneuf, M., additional, Jobard, E., additional, Peguet, E., additional, Grasset, D., additional, Bouret, J. F., additional, Bicheler, V., additional, Ulvoas, A., additional, Miglianico, L., additional, Chouzenoux, C., additional, Deguiral, P., additional, Derenne, L., additional, Martin, D., additional, Langlet, P. Michel, additional, Bodin, C., additional, Rossi, V., additional, Barré, S., additional, Cojocarasu, O., additional, Naveau Ploux, C., additional, Vidal, A. M., additional, Cumin, I., additional, Egreteau, J., additional, Brouard, A., additional, Matysiak Budnik, T., additional, Thomaré, P., additional, Le Bris Michel, A. S., additional, Piriou, G., additional, Largeau, R., additional, Elhannani, C., additional, Crespeau, E., additional, Suberville, F., additional, Bourgeois, H., additional, Riche, C., additional, Lagadec, D. Déniel, additional, Marhuenda, F., additional, and Grudé, F., additional

Published
2014
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14. Efficacy and tolerability of casodex in patients with advanced prostate-cancer

Author

Lunglmayr, G, Alfthan, O, Altwein, Je, Blackledge, G, Blacklock, Nj, Bono, A, Bouffioux, C., Channer, K, Debruyne, F, Denis, L, Disilverio, F, Grasset, D, Haeflinger, Jm, Harland, S, Heijbroek, Rp, Hoisaeter, Pa, Iversen, P, Jaeger, N, Keuppens, F, Khoe, Gs, Klarskov, P., Kontturi, M., Kuber, W, Kums, Jjm, Lardenoye, Jg, Leduc, A, Moehring, K., Newling, D, Pavonemacaluso, M, Permi, J, Rasmussen, F, Rossetti, Sr, Sander, S, Sarramon, Jp, Smith, Ph, Tveter, K., Tyrrell, Cj, Usai, E., Vallancien, Gmb, Vancangh, Pj, Varenhorst, E, Weissbach, L, Whelan, P, Williams, Jl, Zalcberg, J, Zattoni, Filiberto, and Dawes, Pm

Published
1995

15. Endoscopic screening for esophageal squamous-cell carcinoma in high-risk patients: a prospective study conducted in 62 french endoscopy centers

Author

Dubuc, J., primary, Legoux, J.-L., additional, Winnock, M., additional, Seyrig, J.-A., additional, Barbier, J.-P., additional, Barrioz, T., additional, Laugier, R., additional, Boulay, G., additional, Grasset, D., additional, Sautereau, D., additional, Grigoresco, D., additional, Butel, J., additional, Scoazec, J.-Y., additional, and Ponchon, T., additional

Published
2006
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17. Chronic hepatitis B treatment outside therapeutic protocols. Results of a french descriptive study

Author

Lahmek Sr., Pierre, primary, Cadranel, Jean-Francois, additional, Lesgourgues, Bruno, additional, Ahmed, N. Si, additional, Eugene, C., additional, Fontange, T., additional, Blasquez, M., additional, Bellaiche, G., additional, Nahon, S., additional, Chousterman, M., additional, Henrion, J., additional, Grasset, D., additional, Gargot, D., additional, Bettan, L., additional, Pilette, C., additional, Moindrot, H., additional, Medini, A., additional, and Denis, J., additional

Published
2003
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37. In situ piezoelectric extracorporeal shock wave lithotripsy of ureteric stones.

Author

ROBERT, M., DELBOS, O., GUITER, J., and GRASSET, D.

Abstract

Objective To evaluate the efficacy of the EDAP LT 02 lithotripter for the in situ treatment of ureteric calculi. Patients and methods One hundred consecutive patients presenting with ureteric calculi were treated with in situ piezoelectric extracorporeal shock wave lithotripsy (ESWL) using the EDAP LT 02 lithotripter. There were 49 patients with upper, nine with mid and 42 with lower ureteric stones. The largest diameter of the stones varied from 7 to 21 mm (mean 9.6 mm). Mild or severe hydronephrosis was present in 53 cases. Mid and lower ureteric stones were treated with the patients in the prone position, with no anaesthesia or pre-medication, and upper ureteric stones in the supine position, with intravenous sedation in 44 cases. Results Localization of the stones was easy in 81 cases and more difficult in 19, but an intravenous pyelogram was only necessary in three cases. The number of sessions per patient varied from 1 to 3 (mean 1.17). Complete success rate was achieved in 75% of patients and partial success (residual stones ≤ 3 mm) in 6%. The stone-free rate was statistically affected by stone size but was independent of stone localization or the degree of obstruction. The rate of infective and obstructive complications was 14% and auxiliary treatments were necessary in 5% of patients. Conclusion In situ piezoelectric ESWL with the EDAP LT 02 device is a convenient and efficient method for the treatment of ureteric stones. [ABSTRACT FROM AUTHOR]

Published
1995
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38. Pharmacodynamic and pharmacokinetic study of propranolol in patients with cirrhosis and portal hypertension.

Author

Cales, P, Grasset, D, Ravaud, A, Meskens, C, Blanc, M, Vinel, JP, Cotonat, J, and Pascal, JP

Abstract

1. The aim of this study was to investigate the pharmacokinetics and the beta-adrenoceptor blocking activity according to time of conventional (C) and long acting (LA) propranolol in cirrhotic patients. Twenty-four patients with alcoholic cirrhosis and oesophageal varices were randomly assigned to receive either 160 mg C propranolol, 160 mg LA propranolol or placebo acutely and then following repeated administration (acute and chronic phases). Thereafter propranolol concentrations and beta-adrenoceptor blockade (resting and exercise heart rates) were measured at different intervals. 2. The Cmax was significantly higher with C propranolol in both phases. The time of Cmax was significantly later with LA propranolol in both phases. The AUCs were significantly higher after chronic administration with both formulations of propranolol. 3. The exercise peaks of beta-adrenoceptor blockade were similar between the two formulations and between the two phases of administration of propranolol. The duration of effective beta- adrenoceptor blockade was significantly longer in the chronic phase and seemed to be longer with LA than with C propranolol although this was not significant (72 +/- 31 vs 48 +/- 18 h, respectively). 4. There was a significant correlation between the log propranolol concentration and exercise heart rate but not with resting heart rate. No correlation could be demonstrated between pharmacological data and the Child Pugh score. 5. We conclude that in cirrhotic patients exercise testing was a reliable method in the assessment of beta-adrenoceptor blockade. Pharmacology of propranolol was found to be different according to the formulation or to the phase of administration. [ABSTRACT FROM AUTHOR]

Published
1989
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40. Evaluation in usual practice of the bevacizumab-FOLFIRI combination for the first-line treatment of patients with unresectable metastatic colorectal cancer treated in 2006: focus on resected patients and oncogeriatrics

Author

Metges, J. P., Lebot, M. A., Faroux, R., Riaud, F., Gamelin, E., Capitain, O., Guérin Meyer, V., Leynia, P., Douillard, J. Y., Senellart, H., Rochard, S., Louvigné, C., Campion, L., Dupuis, O., Grollier, C., Achour, N. A., Person, B., Raoul, J. L., Boucher, E., Bertrand, C., Ramée, J. F., Guivarch, L., Etienne, P. L., Roussel, S., Desclos, H., Julien, M. N., Labarre, M. I., Klein, V., Bessard, R., Stampfli, C., Royet, F., Faycal, J., Gouva, S., Le Bihan, G., Couturier, M., Gourlaouen, A., Bertholom, C., Porneuf, M., Jobard, E., Peguet, E., Grasset, D., Bouret, J. F., Bicheler, V., Ulvoas, A., Miglianico, L., Chouzenoux, C., Deguiral, P., Derenne, L., Martin, D., Langlet, P. Michel, Bodin, C., Rossi, V., Barré, S., Cojocarasu, O., Naveau Ploux, C., Vidal, A. M., Cumin, I., Egreteau, J., Brouard, A., Matysiak Budnik, T., Thomaré, P., Le Bris Michel, A. S., Piriou, G., Largeau, R., Elhannani, C., Crespeau, E., Suberville, F., Bourgeois, H., Riche, C., Lagadec, D. Déniel, Marhuenda, F., and Grudé, F.

Subjects
Bevacizumab, Elderly patients, Original Article / Article Original, Liver surgical resection, Cancer colorectal métastatique, Oncology, Metastatic colorectal cancer, Pratique courante, Résection hépatique, Cohort, Cohorte, Daily practice, Sujet âgé
Abstract

In 2006, bevacizumab, a targeted therapy agent was combined with FOLFIRI for the firstline treatment of patients with unresectable metastatic colorectal cancer.A study on a homogenous series of 111 patients from the Brittany and Pays de la Loire areas who received bevacizumab-FOLFIRI as first-line treatment in 2006 showed the following results: 51 responses, 29 stabilisations, 21 progressions and 10 cases of toxicity prior to assessment. Median overall survival (OS) was 25.1 months and median progression-free survival was 10.2 months. Surgery secondary to treatment tripled median OS which reached 59.2 months in resected patients versus 18.8 months in unresected patients. Comparison of patients aged more or less than 70 years showed no differences in terms of benefits or risks.Bevacizumab-FOLFIRI could be administered as part of a routine care protocol to elderly patients previously evaluated by a geriatric assessment and validated by a multidisciplinary staff.En 2006, bevacizumab-FOLFIRI représente la thérapie ciblée administrable dès la première ligne chez les patients porteurs d’un cancer colorectal métastatique non opérable. Une série homogène de 111 patients colligés en région Bretagne et Pays de la Loire ayant reçu du bevacizumab- FOLFIRI en première ligne en 2006 révèle les résultats suivants: 51 réponses, 29 stabilités, 21 progressions et 10 toxicités avant évaluation. La médiane de survie globale (OS) est de 25,1 mois et la médiane de survie sans progression (PFS) de 10,2 mois. Dans le cas d’une chirurgie secondaire, l’OS médian triple de 18,8 mois chez les patients non réséqués versus 59,2 mois ceux réséqués. En comparant les sujets âgés de plus et de moins de 70 ans, aucune différence n’a été mise en évidence en termes de bénéfice ou de risque. Bevacizumab-FOLFIRI pourrait être administré en pratique courante chez les personnes âgées sous couvert d’une évaluation gériatrique et d’une approche multidisciplinaire.

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42. We visited for you: the urological clinic in Warsaw

Author

Grasset D

Subjects
Hospitals, University, medicine.medical_specialty, business.industry, Urology, Emergency medicine, medicine, Hospital Departments, Medical emergency, Poland, medicine.disease, business
Published
1977

47. The ThomX ICS source

Author

Kevin Dupraz, Muath Alkadi, Manuel Alves, Loic Amoudry, Didier Auguste, Jean-Luc Babigeon, Michel Baltazar, Alain Benoit, Julien Bonis, Jean Bonenfant, Christelle Bruni, Kevin Cassou, Jean-Noël Cayla, Thomas Chabaud, Iryna Chaikovska, Sophie Chance, Vincent Chaumat, Ronic Chiche, Alain Cobessi, Patrick Cornebise, Olivier Dalifard, Nicolas Delerue, Remy Dorkel, Denis Douillet, Jean-Phillipe Dugal, Noureddine El Kamchi, Mohamed El Khaldi, Ezgi Ergenlik, Pierre Favier, Marco Fernandez, Alexis Gamelin, Jean-Francois Garaut, Luca Garolfi, Philippe Gauron, Frédéric Gauthier, Alexandre Gonnin, Denis Grasset, Eric Guerard, Hayg Guler, Jacques Haissinski, Emmanuel Herry, Gregory Iaquaniello, Marie Jacquet, Eric Jules, Vlacheslav Kubytskyi, Marc Langlet, Titouan Le Barillec, Jean-François Ledu, Damien Leguidec, Bruno Leluan, Pierre Lepercq, Frédéric Letellier-Cohen, Rodolphe Marie, Jean-Claude Marrucho, Aurélien Martens, Christophe Mageur, Gabriel Mercadier, Bruno Mercier, Eric Mistretta, Hugues Monard, Alexandre Moutardier, Olivier Neveu, Daniele Nutarelli, Maher Omeich, Yann Peinaud, Yann Petrilli, Marc Pichet, Eric Plaige, Christophe Prévost, Philippe Rudnicky, Viktor Soskov, Monique Taurigna-Quéré, Stéphane Trochet, Cynthia Vallerand, Olivier Vitez, François Wicek, Sébastien Wurth, Fabian Zomer, Patrick Alexandre, Rachid Ben El Fekih, Philippe Berteaud, François Bouvet, Renaud Cuoq, Antonio Diaz, Yannick Dietrich, Massamba Diop, Dominique Pedeau, Eric Dupuy, Fabrice Marteau, Dias Helder, Nicolas Hubert, José Veteran, Marie Labat, Alain Lestrade, Antoine Letrésor, Robert Lopes, Alexandre Loulergue, Marc Louvet, Patrick Marchand, Moussa El Ajjouri, Didier Muller, Amor Nadji, Laurent Nadolski, Ryutaro Nagaoka, Sylvain Petit, Jean-Pierre Pollina, Fernand Ribeiro, Manuel Ros, Julien Salvia, Sébastien Bobault, Mourad Sebdaoui, Rajesh Sreedharan, Yazid Bouanai, Jean-Louis Hazemann, Jean-Louis Hodeau, Emmanuel Roy, Philippe Jeantet, Jérôme Lacipière, Pierre Robert, Jean-Michel Horodynski, Harold Bzyl, Christophe Chapelle, Marica Biagini, Philippe Walter, Alberto Bravin, William Del Net, Eric Lahéra, Olivier Proux, Hélène Elleaume, Eric Cormier, Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Matériaux, Rayonnements, Structure (MRS), Institut Néel (NEEL), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), SERAS (SERAS), Ingénierie Radioprotection Sûreté Démantèlement (IRSD), Laboratori Nazionali di Frascati (LNF), Istituto Nazionale di Fisica Nucleare (INFN), Laboratoire d'Archéologie Moléculaire et Structurale (LAMS), Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), European Synchrotron Radiation Facility (ESRF), Observatoire des Sciences de l'Univers de Grenoble (OSUG ), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA), Rayonnement Synchrotron et Recherche Medicale (RSRM), European Synchrotron Radiation Facility (ESRF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), LETELLIER, Frédéric, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Matériaux, Rayonnements, Structure (NEEL - MRS), Service Etudes et Réalisation d'Appareillages Scientifiques (NEEL - SERAS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Grenoble Alpes (UGA)-Météo-France, Dupraz, K, Alkadi, M, Alves, M, Amoudry, L, Auguste, D, Babigeon, J, Baltazar, M, Benoit, A, Bonis, J, Bonenfant, J, Bruni, C, Cassou, K, Cayla, J, Chabaud, T, Chaikovska, I, Chance, S, Chaumat, V, Chiche, R, Cobessi, A, Cornebise, P, Dalifard, O, Delerue, N, Dorkel, R, Douillet, D, Dugal, J, El Kamchi, N, El Khaldi, M, Ergenlik, E, Favier, P, Fernandez, M, Gamelin, A, Garaut, J, Garolfi, L, Gauron, P, Gauthier, F, Gonnin, A, Grasset, D, Guerard, E, Guler, H, Haissinski, J, Herry, E, Iaquaniello, G, Jacquet, M, Jules, E, Kubytskyi, V, Langlet, M, Le Barillec, T, Ledu, J, Leguidec, D, Leluan, B, Lepercq, P, Letellier-Cohen, F, Marie, R, Marrucho, J, Martens, A, Mageur, C, Mercadier, G, Mercier, B, Mistretta, E, Monard, H, Moutardier, A, Neveu, O, Nutarelli, D, Omeich, M, Peinaud, Y, Petrilli, Y, Pichet, M, Plaige, E, Prevost, C, Rudnicky, P, Soskov, V, Taurigna-Quere, M, Trochet, S, Vallerand, C, Vitez, O, Wicek, F, Wurth, S, Zomer, F, Alexandre, P, Ben El Fekih, R, Berteaud, P, Bouvet, F, Cuoq, R, Diaz, A, Dietrich, Y, Diop, M, Pedeau, D, Dupuy, E, Marteau, F, Helder, D, Hubert, N, Veteran, J, Labat, M, Lestrade, A, Letresor, A, Lopes, R, Loulergue, A, Louvet, M, Marchand, P, El Ajjouri, M, Muller, D, Nadji, A, Nadolski, L, Nagaoka, R, Petit, S, Pollina, J, Ribeiro, F, Ros, M, Salvia, J, Bobault, S, Sebdaoui, M, Sreedharan, R, Bouanai, Y, Hazemann, J, Hodeau, J, Roy, E, Jeantet, P, Lacipiere, J, Robert, P, Horodynski, J, Bzyl, H, Chapelle, C, Biagini, M, Walter, P, Bravin, A, Del Net, W, Lahera, E, Proux, O, Elleaume, H, and Cormier, E

Subjects
Beamline, ThomX, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], General Physics and Astronomy, 01 natural sciences, law.invention, 010309 optics, X-ray, Optics, law, 0103 physical sciences, Laser power scaling, Physics, Machine description, 010308 nuclear & particles physics, business.industry, Compton scattering, [PHYS.PHYS.PHYS-ACC-PH] Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], Laser, High power Fabry-Perot cavity, lcsh:QC1-999, Proof of concept, Compact compton source, business, Beam (structure), lcsh:Physics
Abstract

International audience; ThomX is a new generation Compact Compton Source. It is currently commissioned by and at the IJCLab (Laboratoire de physique des 2 infinis - Irène Joliot-Curie (UMR9012)) at Orsay. The first beam is expected at the begining of 2021. The aim of ThomX is to demonstrate the characteristics of an intense and Compact (lab-size) X-ray source based on Compton Scattering. The performances are mostly driven by the laser optical system which is above the state of the art of stored laser power. Proof of principle of various X-ray techniques will be performed thanks to the versatile ThomX beamline. Firstly, this article presents the machine description. Secondly, the issues and limits of the laser system are discussed. Then, the ThomX beamline is described and the machine status conclude the ThomX presentation. Finally, the expected performances for the next years and the possible experiments that can be made with this new machine are detailed.

Published
2020

48. Prophylactic Proton Pump Inhibitors in Upper Gastrointestinal Bleeding: Impact and Underprescription in a French Multicentric Cohort.

Author

El Hajj W, Nahon S, Fares E, Quentin V, Grasset D, Arpurt JP, Skinazi F, Vitte RL, Costes L, Remy AJ, Locher C, and Macaigne G

Abstract

Background: Appropriate prescription of Proton pump inhibitors (PPIs) remains an important concern amid the rising overuse. A gap exists in the literature regarding the benefit of PPI prophylaxis and the consequences of underprescription in patients at risk for upper gastrointestinal bleeding (UGIB)., Aims: This study aims to describe the characteristics of hemorrhage in relation to PPI use in patients experiencing UGIB, with a focus on high-risk individuals requiring gastroprotection., Methods: Data from a French multicentric cohort of patients experiencing UGIB were analyzed. Patients using PPI were compared to those without PPI considering bleeding etiologies and outcomes of peptic ulcer disease (PUD)-related hemorrhage. The rate of PPI use and its effect on bleeding characteristics in high-risk populations, defined based on international guidelines, were also assessed., Results: Among 2497 included patients, 31.1% were on PPI at bleeding onset. PPI users exhibited a significantly lower rate of PUD-related bleeding in comparison with those without PPI (24.7 vs 40.8%, respectively, p < 0.0001). Similar difference was observed in high-risk populations, of whom, only 40.3% had gastroprotection with PPI before bleeding onset. PPI prophylaxis, however, did not influence the severity of bleeding in the general study population or in high-risk groups. Multivariate analysis identified age, comorbidities, and having more than two anti-thrombotic agents as predictors of severe bleeding., Conclusions: PPI users appear to have a lower rate of bleeding ulcers compared to non-users. However, underprescription in high-risk groups raises the need for standardized care to ensure appropriate PPI use., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2024
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49. Significant Reduction of Radiation Exposure Using Specific Settings of the O-Arm for Percutaneous Cementoplasty in Accordance With the ALARA Principle.

Author

Prod'homme M, Grasset D, Akiki A, Helfer L, Dietrich G, Müller JP, Tomasoni M, Sellami M, and Boscherini D

Abstract

Background: Three-dimensional (3D) navigation has become routinely used in spine surgery, allowing more accurate and safe procedures. However, radiation exposure related to the use of imaging is an unresolved issue, and information about it is relatively scarce. The "as low as reasonably achievable" (ALARA) principle aims to reduce the radiation exposure for the patients as low as possible. The objective of this study was to compare the effective dose related to the use of the O-arm in standard settings with adapted features for dose reduction during percutaneous cementoplasty., Methods: From March 2021 to October 2022, all consecutive patients who underwent navigated percutaneous cementoplasty with the use of the O-arm were prospectively included. Demographic, operative, irradiation, and radiological data were collected. The main outcome was the effective dose (E) in millisievert (mSv). Secondary outcomes were the absolute risk of cancer (AR) in percent equivalent to a whole-body exposition, operative time, and radiological results according to Garnier. In group A, patients were operated on with standard settings of the O-arm, whereas in group B, navigation on the field of view, collimation, and low-dose settings were used., Results: A total of 70 patients were included in the study: 43 in group A and 27 in group B. Also, 109 vertebrae were operated: 59 in group A and 50 in group B. Mean E was significantly higher in group A than in group B (9.94 and 4.34 mSv, respectively; P < 0.01). The 3D-related E followed the same trend (7.82 and 3.97 mSv, respectively), as did 2-dimensional-related E (2.12 and 0.37 mSv, respectively; P < 0.01). Average AR was also significantly higher in group A than in group B (5.10 -4 % and 2.10 -4 % respectively; P < 0.01). Operative time was similar in both groups, but the rate of satisfactory radiological results was higher in group A than in group B (95% and 84%, respectively; P = 0.11), and we found similar rates of cement leakage (22% and 24%, respectively; P = 0.71)., Conclusions: The application of settings of the O-arm in accordance with the ALARA principle helped to significantly reduce the radiation exposure and should be routinely used for O-arm-assisted cementoplasty procedures., Clinical Relevance: This study details technical aspects and settings that may help users of the O-arm to decrease radiation exposure to patients and surgeons alike, especially in cementoplasty procedures, as well as in other procedures performed under O-arm guidance., (This manuscript is generously published free of charge by ISASS, the International Society for the Advancement of Spine Surgery. Copyright © 2023 ISASS. To see more or order reprints or permissions, see http://ijssurgery.com.)

Published
2023
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50. The PRSS3P2 and TRY7 deletion copy number variant modifies risk for chronic pancreatitis.

Author

Masson E, Ewers M, Paliwal S, Kume K, Scotet V, Cooper DN, Rebours V, Buscail L, Rouault K, Abrantes A, Aguilera Munoz L, Albouys J, Alric L, Amiot X, Archambeaud I, Audiau S, Bastide L, Baudon J, Bellaiche G, Bellon S, Bertrand V, Bideau K, Billiemaz K, Billioud C, Bonnefoy S, Borderon C, Bournet B, Breton E, Brugel M, Buscail L, Cadiot G, Camus M, Carpentier-Pourquier M, Chamouard P, Chaput U, Chen JM, Cholet F, Ciocan DM, Clavel C, Coffin B, Coimet-Berger L, Cosconea S, Creveaux I, Culetto A, Daboussi O, De Mestier L, Degand T, D'engremont C, Denis B, Dermine S, Desgrippes, Drouet D'Aubigny A, Enaud R, Fabre A, Férec C, Gargot D, Gelsi E, Gentilcore E, Gincul R, Ginglinger-Favre E, Giovannini M, Gomercic C, Gondran H, Grainville T, Grandval P, Grasset D, Grimaldi S, Grimbert S, Hagege H, Heissat S, Hentic O, Herber-Mayne A, Hervouet M, Hoibian S, Jacques J, Jais B, Kaassis M, Koch S, Lacaze E, Lacroute J, Lamireau T, Laurent L, Le Guillou X, Le Rhun M, Leblanc S, Levy P, Lievre A, Lorenzo D, Maire F, Marcel K, Masson E, Mauillon J, Morgant S, Moussata D, Muller N, Nambot S, Napoleon B, Olivier A, Pagenault M, Pelletier AL, Pennec O, Pinard F, Pioche M, Prost B, Queneherve L, Rebours V, Reboux N, Rekik S, Riachi G, Rohmer B, Roquelaure B, Rosa Hezode I, Rostain F, Saurin JC, Servais L, Stan-Iuga R, Subtil C, Tanneche J, Texier C, Thomassin L, Tougeron D, Vuitton L, Wallenhorst T, Wangerme M, Zanaldi H, Zerbib F, Bhaskar S, Kikuta K, Rao GV, Hamada S, Reddy DN, Masamune A, Chandak GR, Witt H, Férec C, and Chen JM

Subjects
Humans, Alleles, DNA Copy Number Variations genetics, Genetic Predisposition to Disease, Genotype, Mutation, Trypsin genetics, Pancreatitis, Chronic genetics, Trypsinogen genetics
Abstract

Background: PRSS1 and PRSS2 constitute the only functional copies of a tandemly-arranged five-trypsinogen-gene cluster (i.e., PRSS1, PRSS3P1, PRSS3P2, TRY7 and PRSS2) on chromosome 7q35. Variants in PRSS1 and PRSS2, including missense and copy number variants (CNVs), have been reported to predispose to or protect against chronic pancreatitis (CP). We wondered whether a common trypsinogen pseudogene deletion CNV (that removes two of the three trypsinogen pseudogenes, PRSS3P2 and TRY7) might be associated with CP causation/predisposition., Methods: We analyzed the common PRSS3P2 and TRY7 deletion CNV in a total of 1536 CP patients and 3506 controls from France, Germany, India and Japan by means of quantitative fluorescent multiplex polymerase chain reaction., Results: We demonstrated that the deletion CNV variant was associated with a protective effect against CP in the French, German and Japanese cohorts whilst a trend toward the same association was noted in the Indian cohort. Meta-analysis under a dominant model yielded a pooled odds ratio (OR) of 0.68 (95% confidence interval (CI) 0.52-0.89; p = 0.005) whereas an allele-based meta-analysis yielded a pooled OR of 0.84 (95% CI 0.77-0.92; p = 0.0001). This protective effect is explicable by reference to the recent finding that the still functional PRSS3P2/TRY7 pseudogene enhancers upregulate pancreatic PRSS2 expression., Conclusions: The common PRSS3P2 and TRY7 deletion CNV was associated with a reduced risk for CP. This finding provides additional support for the emerging view that dysregulated PRSS2 expression represents a discrete mechanism underlying CP predisposition or protection., Competing Interests: Declaration of competing interest The authors are unaware of any conflict of interest., (Copyright © 2022 IAP and EPC. Published by Elsevier B.V. All rights reserved.)

Published
2023
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