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8. OP0289 SHORT- AND LONG-TERM EFFICACY OF ULTRASOUND-GUIDED NEEDLE FRAGMENTATION OR LAVAGE (BARBOTAGE) IN SYMPTOMATIC SHOULDER CALCIFIC TENDONITIS REFRACTORY TO SUBACROMIAL STEROID INJECTION. PROSPECTIVE LONGITUDINAL STUDY OF 181 PATIENTS.

Author

Casado, E., primary, Garcia-Cirera, S., additional, Retamozo, S., additional, Rusiñol, M., additional, Costa Moya, E., additional, Lluís, L., additional, Calvet, J., additional, and Gratacos-Masmitja, J., additional

Published
2022
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14. AB0542 EVALUATION OF APREMILAST USE IN THE ROUTINE CLINICAL PRACTICE IN PATIENTS WITH PSORIATIC ARTHRITIS NAÏVE TO BIOLOGICAL TREATMENTS

Author

Gratacos-Masmitja, J., primary, Álvarez Vega, J. L., additional, Beltrán, E., additional, Urruticoechea-Arana, A., additional, Fito-Manteca, C., additional, Maceiras, F., additional, Belzunegui Otano, J. M., additional, Fernández-Melón, J., additional, Chamizo Carmona, E., additional, Hernández, A., additional, Ros, I., additional, Pascual, E., additional, and Torre, J. C., additional

Published
2021
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16. POS0986 GENDER DIFFERENCES IN DISEASE CONTROL AND HEALTH STATUS IN PATIENTS WITH ANKYLOSING SPONDYLITIS IN CLINICAL PRACTICE IN SPAIN: RESULTS OF THE MiDAS STUDY

Author

Fernández-Carballido, C., primary, Gratacos-Masmitja, J., additional, De Miguel, E., additional, Del Río Martínez, P. S., additional, Martínez González, O., additional, Fernandez-Nebro, A., additional, Vela-Casasempere, P., additional, Sanabra, C., additional, and Sastré, C., additional

Published
2021
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19. POS1044 EFFECT OF SECUKINUMAB VERSUS ADALIMUMAB ON ACR CORE COMPONENTS AND HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH PSORIATIC ARTHRITIS: RESULTS FROM THE EXCEED STUDY

Author

Goupille, P., primary, Behrens, F., additional, Coates, L. C., additional, Gratacos-Masmitja, J., additional, Mease, P. J., additional, Gladman, D. D., additional, Nash, P., additional, Kavanaugh, A., additional, Martin, R., additional, Bao, W., additional, Gaillez, C., additional, and Mcinnes, I., additional

Published
2021
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29. OP0227 SECUKINUMAB VERSUS ADALIMUMAB HEAD-TO-HEAD COMPARISON IN BIOLOGIC-NAÏVE PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS THROUGH 52-WEEKS (EXCEED): A RANDOMISED, DOUBLE-BLIND, PHASE-3B STUDY

Author

Mcinnes, I., primary, Behrens, F., additional, Mease, P. J., additional, Kavanaugh, A., additional, Ritchlin, C. T., additional, Nash, P., additional, Gratacos-Masmitja, J., additional, Goupille, P., additional, Korotaeva, T., additional, Gottlieb, A. B., additional, Martin, R., additional, Ding, K., additional, Pellet, P., additional, Mpofu, S., additional, and Pricop, L., additional

Published
2020
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31. AB0700 RADIOGRAPHIC PROGRESSION IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS UNDER TREATMENT WITH TNF INHIBITORS. DATA FROM REGISPONSERBIO (SPANISH REGISTER OF BIOLOGICAL THERAPY IN SPONDYLOARTHRITIDES)

Author

Llop Vilaltella, M., primary, Moreno, M., additional, Gratacos-Masmitja, J., additional, Navarro-Compán, V., additional, De Miguel, E., additional, Pilar, F. U., additional, Clavaguera, T., additional, Linares Ferrando, L. F., additional, Joven-Ibáñez, B., additional, and Juanola-Roura, X., additional

Published
2020
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34. AB0814 SUSTAINED IMPROVEMENTS IN PHYSICAL FUNCTION, QUALITY OF LIFE, AND WORK PRODUCTIVITY WITH IXEKIZUMAB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND PREVIOUS INADEQUATE RESPONSE TO TUMOUR NECROSIS FACTOR-INHIBITORS: 3-YEAR RESULTS FROM SPIRIT-P2 TRIAL

Author

Orbai, A. M., primary, Gratacos-Masmitja, J., additional, Dokoupilova, E., additional, Combe, B., additional, Constantin, A., additional, Gellett, A. M., additional, Sprabery, A. T., additional, Birt, J., additional, Geneus, V., additional, and Nash, P., additional

Published
2020
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36. The comparative responsiveness of Hospital Universitario Princesa Index and other composite indices for assessing rheumatoid arthritis activity

Author

Gonzalez-Alvaro, Isidoro, Castrejon, Isabel, Carmona, Loreto, Dougados, M., Huizinga, T., Abu Shakra, M., Alberts, A., Alperi Lopez, M., Amital, H., Aringer, M., Aslanidis, S., Berenbaum, F., Bijlsma, H., Blanco Garcia, F. J., Bliddal, H., Borofsky, M., Brocq, O., Buldakov, S., Cantini, F., Carreno Perez, L., Chahade, W., Ciconelli, R., Codreanu, C., Dahlqvist, S. R., Damjanov, N., Diamantopoulos, A., Dimdina, L., Dimic, A., Dorokhov, A., Dubikov, A., Fadienko, G., Fano, N., Ferreira, G., Gabrielli, A., Gaffney, K., Gaudin, P., Gerlag, D. M., Gerli, R., Goncalves, C. R., Hansen, M. S., Hanvivadhanakul, P., Hoili, C., Hou, A., Hunter, J., Ilic, T., Ionescu, R., Kaine, J., Kakurina, N., Kamalova, R., Kelly, T., Knyazeva, L., Krumina, L., Kurthen, R., Lagrone, R. P., Lapadula, G., Lavrentjevs, V, Lawson, J. G., Lazic, Z., Lejnieks, A., Levy, Y., Lexberg, A., Mader, R., Mariette, X., Markovits, D., Mola, Martin E., Maugars, Y., Guarch, Maymo J., Mazurov, V., I, Mikkelsen, K., Vergles, Morovic J., Nabizadeh, S., Nanagara, R., Nasonov, E. L., Sarabia, Navarro F., Neumann, T., Novak, S., Olech, E., Oza, M., Paran, D., Parsik, E., Pegram, S., Suarez, Pombo M., Popova, T., Puechal, X., Raja, N., Ridley, D., Rosner, I, Rubbert-Roth, A., Rudin, A., Saraux, A., Saulite-Kandevica, D., Settas, L., Sfikakis, P., Sheeran, T., Sizikov, A., Stamenkovic, D., Stefanovic, D., Stolow, J. B., Tan, A. L., Tebib, J., Tishler, M., Tony, H. P., Troum, O. M., Uaratanawong, S., Ucar Angulo, E., Valenzuela, G., van der Laken, K., Van Laar, J., van Riel, P. L. C. M., Vasilopoulos, D., Veldi, T., Vinogradova, I, Vosse, D., Wassenberg, S., Weidmann, C., Weitz, M., Wollenhaupt, J., Xavier, R., Yakupova, S., Zagar, I, Zavgorodnaja, T., Zemerova, E., Zisman, D., Zonova, E., Camona, Loreto, Abasolo Alcazar, L., Alegre de Miguel, C., Andreu Sanchez, J. L., Aragon Diez, A., Balsa Criado, A., Batlle Gualda, E., Belmonte Serrano, M. A., Beltran Audera, J., Beltran Fabregat, J., Bonilla Hernan, G., Caro Fernandez, N., Casado, E., Cebrian Mendez, L., Corteguera Coro, M., Cuadra Diaz, J. L., Cuesta, E., Fiter Areste, J., Freire Gonzalez, M., Galindo Izquierdo, M., Garcia Meijide, J. A., Garcia Gomez, M. C., Gimenez Ubeda, E., Gomez Centeno, E., Gomez Vaquero, C., Gonzalez Fernandez, M. J., Gonzalez Gomez, M. L., Gonzalez Hernandez, T., Gonzalez-Alvaro, I, Gonzalez-Montagut Gomez, C., Grandal Delgado, Y., Gratacos Masmitja, J., Hernandez del Rio, A., Instxaurbe, A. R., Irigoyen Oyarzabal, M., V, Jimenez Palop, M., Juan Mas, A., Judez Navarro, E., Larrosa Padro, M., Lopez Longo, F. J., Loza Santamaria, E., Maese Manzano, J., Manero Ruiz, F. J., Mateo Bernardo, I, Mayordomo Gonzalez, L., Mazzucheli, R., Medrano San Idelfonso, M., Naranjo Hernandez, A., Pecondon Espanol, A., Peiro Callizo, E., Quiros Donate, J., Ramos Lopez, P., Rivera Redondo, J., Rodriguez Gomez, M., Rodriguez Lopez, M., Rosello Pardo, R., Sampedro Alvarez, J., Sanmarti Sala, R., Rey Rey, Santos J., Tena Marsa, X., Tenorio Martin, M., Torres Martin, M. C., Urena Garnica, I, Valdazo de Diego, J. P., Valls, M., Villaverde Garcia, V., Zarco Montejo, P., Zubieta Tabernero, J., Balsa, Alejandro, Sanmarti, Raimon, Cabezas, J. A., Cantalejo, M., Chamizo, E., Ciruelo, E., Corrales, A., Cruz, A., Diaz, C., Fiter, J., Freire, M. M., Galindo, M., Garcia de Vicuna, M. R., Gelman, S. M., Gonzalez Crespo, R., Gonzalez Fernandez, C., Gracia, A., Granados, J., Guzman, M. A., Irigoyen, M., V, Juan, A., Juanola, X., Laiz, A., Manero, F. J., Martinez, A., Martinez, F., Mata, C., Maymo, J., Navarro, F. J., Peiro, E., Perez, F., Perez, G., Perez, M., Pujol, M., Quiros, J., Ribas, B., Riera, M., Rivera, J., Rodriguez, J. M., Rosello, R., Tenorio, M., Toyos, F. J., ACT-RAY Study Grp, PROAR Study Grp, EMECAR Study Grp, Interne Geneeskunde, MUMC+: MA Reumatologie (9), and RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation

Subjects
Male, medicine.medical_specialty, Science, humanos, Severity of Illness Index, RECOMMENDATIONS, VALIDATION, VARIABLES, ensayos clínicos como asunto, Arthritis, Rheumatoid, Cohort Studies, Internal medicine, Linear regression, Severity of illness, medicine, Humans, índice de gravedad de la enfermedad, estudios de cohortes, mediana edad, Clinical Trials as Topic, DISEASE-ACTIVITY MEASURES, Multidisciplinary, SCORES, business.industry, Arthritis, resultado del tratamiento, modelos lineales, Secondary data, Gold standard (test), Middle Aged, medicine.disease, Clinical trial, Treatment Outcome, Rheumatoid arthritis, Antirheumatic Agents, Cohort, Linear Models, Medicine, Female, GENDER, business, antirreumáticos, artritis, Cohort study
Abstract

Objective To evaluate the responsiveness in terms of correlation of the Hospital Universitario La Princesa Index (HUPI) comparatively to the traditional composite indices used to assess disease activity in rheumatoid arthritis (RA), and to compare the performance of HUPI-based response criteria with that of the EULAR response criteria. Methods Secondary data analysis from the following studies: ACT-RAY (clinical trial), PROAR (early RA cohort) and EMECAR (pre-biologic era long term RA cohort). Responsiveness was evaluated by: 1) comparing change from baseline (Delta) of HUPI with Delta in other scores by calculating correlation coefficients; 2) calculating standardised effect sizes. The accuracy of response by HUPI and by EULAR criteria was analyzed using linear regressions in which the dependent variable was change in global assessment by physician (Delta GDA-Phy). Results Delta HUPI correlation with change in all other indices ranged from 0.387 to 0.791); HUPI's standardized effect size was larger than those from the other indices in each database used. In ACT-RAY, depending on visit, between 65 and 80% of patients were equally classified by HUPI and EULAR response criteria. However, HUPI criteria were slightly more stringent, with higher percentage of patients classified as non-responder, especially at early visits. HUPI response criteria showed a slightly higher accuracy than EULAR response criteria when using Delta GDA-Phy as gold standard. Conclusion HUPI shows good responsiveness in terms of correlation in each studied scenario (clinical trial, early RA cohort, and established RA cohort). Response criteria by HUPI seem more stringent than EULAR's., Our study was supported by grants RD16/0012/0011 and PI14/00442 from the Ministerio de Economia y Competitividad (Instituto de Salud Carlos III; Spain) and cofunded by the Fondo Europeo de Desarrollo Regional (FEDER). Data from ACT-RAY clinical trial were kindly provided by Hoffmann-La Roche Ltd. No financial support was received from Hoffmann-La Roche Ltd Data from EMECAR and PROAR cohorts were provided by the Spanish Society of Rheumatology. No financial support was received from the Spanish Society of Rheumatology. None of these institutions played any role in the analysis or interpretation of data, nor were they involved in the writing of the manuscript. Roche and Sociedad Espanola de Reumatologia were involved in the collection of data from ACT-RAY, and EMECAR and PROAR, respectively. However, these funders had no role in study design, analysis, decision to publish, or preparation of the manuscript.

Published
2019

37. Points to Consider in the Foundation of Multidisciplinary Units for Psoriatic Arthritis: A Delphi Study and a Systematic Review of the Literature

Author

Gratacos-Masmitja, J, Luelmo-Aguilar, J, Zarco-Montejo, P, Botella-Estrada, R, Carrizosa-Esquivel, AM, Garcia-Vivar, ML, Perez-Barrio, S, Roman-Ivorra, JA, Ruiz-Montesino, MD, and Lopez-Estebaranz, JL

Subjects
Hospital units, Organizations, Rheumatology, Psoriatic arthritis, Multidisciplinary care, Psoriasis, Biological therapy, Dermatology, Consensus development
Abstract

Introduction: In numerous clinical practice guidelines, emphasis is placed on the need for coordinated care of psoriatic arthritis (PsA) between rheumatologists and the objective was to develop experience-based points to consider facilitating the implementation of multidisciplinary units (Dermatology/Rheumatology) for the management of patients with PsA. Methods: A scientific committee of rheumatology and dermatology experts in the management of PsA, and with experience in joint care, discussed the critical aspects of multidisciplinary PsA Units. The discussion became the basis for a Delphi survey in two rounds submitted to a panel of 24 specialists in rheumatology and dermatology not involved in PsA units. The statements and practices that reached a consensus were summarized and further elaborated. Results: After two Delphi rounds, agreement was reached for 49 of the 50 proposed statements. These included a justification of the units, objectives, and utilities, as well as operational aspects of the units, such as the minimal and ideal premises, referral criteria, and necessary resources. The statements were compiled in 11 points to consider. Conclusions: This consensus offers some points to consider, including premises and recommendations, for the development of specialized Units in the management of PsA based on expert opinion. We trust these guidelines may facilitate their implementation in the future.

Published
2017

39. Cut-offs and response criteria for the Hospital Universitario la Princesa Index (HUPI) and their comparison to widely-used indices of disease activity in rheumatoid arthritis

Author

González-Álvaro, I., Castrejón, I., Ortiz, A.M., Toledano, E., Castañeda, S., García-Vadillo, A., Carmona, L., Abasolo Alcazar, L., Miguel, Alegre De, Andreu Sánchez, J.L., Aragón Díez, A., Balsa Criado, A., Batlle Gualda, E., Belmonte Serrano, M.A., Beltrán Audera, J., Beltrán Fabregat, J., Bonilla Hernan, G., Carmona Ortells, L., Caro Fernández, N., Casado, E., Cebrian Mendez, L., Corteguera Coro, M., Cuadra Díaz, J.L., Cuesta, E., Fiter Aresté, J., Freire Gonzalez, M., Galindo Izquierdo, M., García Meijide, J.A., García Gómez, M.C., Giménez Ubeda, E., Gómez Centeno, E., Gómez Vaquero, C., González Fernández, M.J., González Gómez, M.L., González Hernández, T., González-Alvaro, I., González-Montagut Gómez, C., Grandal Delgado, Y., Gratacos Masmitja, J., Hernández, Del R., Instxaurbe, A.R., Irigoyen Oyarzabal, M.V., Jiménez Palop, M., Juan Mas, A., Júdez Navarro, E., Larrosa Padro, M., López Longo, F.J., Loza Santamaria, E., Maese Manzano, J., Manero Ruiz, F.J., Mateo Bernardo, I., Mayordomo González, L., Mazzucheli, R., Medrano, San Idelfonso, Naranjo Hernández, A., Pecondón Español, A., Peiró Callizo, E., Quirós Donate, J., Ramos López, P., Rivera Redondo, J., Rodríguez Gómez, M., Rodríguez López, M., Roselló Pardo, R., Sampedro Alvarez, J., Sanmartí Sala, R., Santos, Rey Rey, Tena Marsá, X., Tenorio Martín, M., Torres Martín, Mc, Ureña Garnica, I., Diego, Valdazo De, Valls, M., Villaverde García, V., Zarco Montejo, P., and Zubieta Tabernero, J.

Abstract

Objective To estimate cut-off points and to establish response criteria for the Hospital Universitario La Princesa Index (HUPI) in patients with chronic polyarthritis. Methods Two cohorts, one of early arthritis (Princesa Early Arthritis Register Longitudinal PEARL] study) and other of long-term rheumatoid arthritis (Estudio de la Morbilidad y Expresión Clínica de la Artritis Reumatoide EMECAR]) including altogether 1200 patients were used to determine cut-off values for remission, and for low, moderate and high activity through receiver operating curve (ROC) analysis. The areas under ROC (AUC) were compared to those of validated indexes (SDAI, CDAI, DAS28). ROC analysis was also applied to establish minimal and relevant clinical improvement for HUPI. Results The best cut-off points for HUPI are 2, 5 and 9, classifying RA activity as remission if =2, low disease activity if >2 and =5), moderate if >5 and

Published
2016

42. Infliximab in refractory spondyloarthropathies: a multicentre 38 week open study

Author

Collantes-Estevez, E, Munoz-Villanueva, MC, Canete-Crespillo, JD, Sanmarti-Sala, R, Gratacos-Masmitja, J, Zarco-Montejo, P, Torre-Alonso, JC, and Gonzalez-Fernandez, C

Subjects
Health
Abstract

Some patients (20-30%) with spondyloarthropathies (SpA) have a persistent and disabling disease, (1) for which a limited number of alternative therapeutic approaches exist. (2) The successful results from randomised, double [...]

Published
2003

44. Points to Consider in the Foundation of Multidisciplinary Units for Psoriatic Arthritis: A Delphi Study and a Systematic Review of the Literature.

Author

Gratacos-Masmitja J, Luelmo-Aguilar J, Zarco-Montejo P, Botella-Estrada R, Carrizosa-Esquivel AM, Garcia-Vivar ML, Perez-Barrio S, Roman-Ivorra JA, Ruiz-Montesino MD, and Lopez-Estebaranz JL

Subjects
Adult, Aged, Aged, 80 and over, Delphi Technique, Female, Humans, Male, Middle Aged, Patient Care Team organization & administration, Surveys and Questionnaires, Arthritis, Psoriatic diagnosis, Arthritis, Psoriatic therapy, Dermatology methods, Interprofessional Relations, Patient Care Team standards, Practice Guidelines as Topic, Rheumatology methods
Abstract

Introduction: In numerous clinical practice guidelines, emphasis is placed on the need for coordinated care of psoriatic arthritis (PsA) between rheumatologists and the objective was to develop experience-based points to consider facilitating the implementation of multidisciplinary units (Dermatology/Rheumatology) for the management of patients with PsA., Methods: A scientific committee of rheumatology and dermatology experts in the management of PsA, and with experience in joint care, discussed the critical aspects of multidisciplinary PsA Units. The discussion became the basis for a Delphi survey in two rounds submitted to a panel of 24 specialists in rheumatology and dermatology not involved in PsA units. The statements and practices that reached a consensus were summarized and further elaborated., Results: After two Delphi rounds, agreement was reached for 49 of the 50 proposed statements. These included a justification of the units, objectives, and utilities, as well as operational aspects of the units, such as the minimal and ideal premises, referral criteria, and necessary resources. The statements were compiled in 11 points to consider., Conclusions: This consensus offers some points to consider, including premises and recommendations, for the development of specialized Units in the management of PsA based on expert opinion. We trust these guidelines may facilitate their implementation in the future., Funding: Pfizer.

Published
2017
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