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801 results on '"Gravitt, Patti E."'

1. Challenges associated with follow-up care after implementation of an HPV screen-and-treat program with ablative therapy for cervical cancer prevention

Author

Morse, Rachel M., Brown, Joanna, Ríos López, E. Jennifer, Prieto, Bryn A., Kohler-Smith, Anna, Gonzales Díaz, Karina, Figueredo Escudero, Magaly, Lenin del Cuadro, Daniel, Vásquez del Aguila, Giannina, Daza Grandez, Henrry, Meza‑Sánchez, Graciela, Tracy, J. Kathleen, Gravitt, Patti E., and Paz‑Soldan, Valerie A.

Published
2024
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5. Relationships of p16 Immunohistochemistry and Other Biomarkers With Diagnoses of Cervical Abnormalities: Implications for LAST Terminology

Author

Castle, Philip E, Adcock, Rachael, Cuzick, Jack, Wentzensen, Nicolas, Torrez-Martinez, Norah E, Torres, Salina M, Stoler, Mark H, Ronnett, Brigitte M, Joste, Nancy E, Darragh, Teresa M, Gravitt, Patti E, Schiffman, Mark, Hunt, William C, Kinney, Walter K, Wheeler, Cosette M, Committee, New Mexico HPV Pap Registry Steering, and Panel, p16 IHC Study

Subjects
Reproductive Medicine, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cervical Cancer, Infectious Diseases, Clinical Research, Cancer, Sexually Transmitted Infections, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Adult, Biomarkers, Tumor, Cyclin-Dependent Kinase Inhibitor p16, Female, Humans, Immunohistochemistry, Middle Aged, Papillomavirus Infections, Uterine Cervical Neoplasms, Uterine Cervical Dysplasia, New Mexico HPV Pap Registry Steering Committee, p16 IHC Study Panel, Clinical Sciences, Pathology, Clinical sciences
Abstract

Context.—Lower Anogenital Squamous Terminology (LAST) standardization recommended p16INK4a immunohistochemistry (p16 IHC) for biopsies diagnosed morphologically as cervical intraepithelial neoplasia (CIN) grade 2 (CIN2) to classify them as low-grade or high-grade squamous intraepithelial lesions (HSILs).Objective.—To describe the relationships of p16 IHC and other biomarkers associated with cervical cancer risk with biopsy diagnoses.Design.—A statewide, stratified sample of cervical biopsies diagnosed by community pathologists (CPs), including 1512 CIN2, underwent a consensus, expert pathologist panel (EP) review (without p16 IHC results), p16 IHC interpretation by a third pathology group, and human papillomavirus (HPV) genotyping, results of which were grouped hierarchically according to cancer risk. Antecedent cytologic interpretations were also available.Results.—Biopsies were more likely to test p16 IHC positive with increasing severity of CP diagnoses, overall (Ptrend ≤ .001) and within each HPV risk group (Ptrend ≤ .001 except for low-risk HPV [Ptrend < .010]). All abnormal grades of CP-diagnosed biopsies were more likely to test p16 IHC positive with a higher HPV risk group (Ptrend < .001), and testing p16 IHC positive was associated with higher HPV risk group than testing p16 IHC negative for each grade of CP-diagnosed biopsies (P < .001). p16 IHC-positive, CP-diagnosed CIN2 biopsies were less likely than CP-diagnosed CIN3 biopsies to test HPV16 positive, have an antecedent HSIL+ cytology, or to be diagnosed as CIN3+ by the EP (P < .001 for all). p16 IHC-positive, CP-diagnosed CIN1 biopsies had lower HPV risk groups than p16 IHC-negative, CP-diagnosed CIN2 biopsies (P < .001).Conclusions.—p16 IHC-positive, CP-diagnosed CIN2 appears to be lower cancer risk than CP-diagnosed CIN3. LAST classification of "HSIL" diagnosis, which includes p16 IHC-positive CIN2, should annotate the morphologic diagnosis (CIN2 or CIN3) to inform all management decisions, which is especially important for young (

Published
2020

8. Women’s perspectives on the acceptability and feasibility of an HPV screen-and-treat approach to cervical cancer prevention in Iquitos, Peru: a qualitative study

Author

Morse, Rachel M., Brown, Joanna, Noble, Helen E., Ríos López, E. Jennifer, Kohler-Smith, Anna, Soto, Sandra, del Cuadro, Daniel Lenin, Gonzales Díaz, Karina, Figueredo Escudero, Magaly, Vásquez del Aguila, Giannina, Carrillo Jara, Lita E., Silva Delgado, Hermann F., Palacios, Victor A., Santos-Ortiz, Carlos, Gravitt, Patti E., and Paz-Soldan, Valerie A.

Published
2022
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13. Comparison of Hybribio GenoArray and Roche Human Papillomavirus (HPV) Linear Array for HPV Genotyping in Anal Swab Samples

Author

Low, Huey Chi, Silver, Michelle I, Brown, Brandon J, Leng, Chan Yoon, Blas, Magaly M, Gravitt, Patti E, and Woo, Yin Ling

Subjects
Genetics, Cervical Cancer, Clinical Research, Prevention, Digestive Diseases, Sexually Transmitted Infections, Cancer, Infectious Diseases, HIV/AIDS, Anal Canal, Anus Neoplasms, Early Detection of Cancer, Genotyping Techniques, Homosexuality, Male, Humans, Male, Papillomaviridae, Papillomavirus Infections, Biological Sciences, Agricultural and Veterinary Sciences, Medical and Health Sciences, Microbiology
Abstract

Human papillomavirus (HPV) is causally associated with anal cancer, as HPV DNA is detected in up to 90% of anal intraepithelial neoplasias and anal cancers. With the gradual increase of anal cancer rates, there is a growing need to establish reliable and clinically relevant methods to detect anal cancer precursors. In resource-limited settings, HPV DNA detection is a potentially relevant tool for anal cancer screening. Here, we evaluated the performance of the Hybribio GenoArray (GA) for genotyping HPV in anal samples, against the reference standard Roche Linear Array (LA). Anal swab samples were obtained from sexually active men who have sex with men. Following DNA extraction, each sample was genotyped using GA and LA. The overall interassay agreement, type-specific, and single and multiple genotype agreements were evaluated by kappa statistics and McNemar's χ(2) tests. Using GA and LA, 68% and 76% of samples were HPV DNA positive, respectively. There was substantial interassay agreements for the detection of all HPV genotypes (κ = 0.70, 86% agreement). Although LA was able to detect more genotypes per sample, the interassay agreement was acceptable (κ = 0.53, 63% agreement). GA had poorer specific detection of HPV genotypes 35, 42, and 51 (κ < 0.60). In conclusion, GA and LA showed good interassay agreement for the detection of most HPV genotypes in anal samples. However, the detection of HPV DNA in up to 76% of anal samples warrants further evaluation of its clinical significance.

Published
2015

15. “Easy women get it”: Pre-existing stigma associated with HPV and cervical cancer in a low-resource setting prior to implementation of an HPV screen-and-treat program

Author

Morse, Rachel M., primary, Brown, Joanna, additional, Gage, Julia C., additional, Prieto, Bryn A., additional, Jurczuk, Magdalena, additional, Matos, Andrea, additional, Vásquez, Javier Vásquez, additional, Reátegui, Reyles Ríos, additional, Meza-Sanchez, Graciela, additional, Córdova, Luis Antonio Díaz, additional, Gravitt, Patti E., additional, Tracy, J. Kathleen, additional, and Paz‑Soldan, Valerie A., additional

Published
2023
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16. Challenges associated with follow-up care after implementation of an HPV screen-and-treat program with ablative therapy for cervical cancer prevention in Iquitos, Peru: a mixed methods study

Author

Morse, Rachel, primary, Brown, Joanna, additional, López, E. Jennifer Ríos, additional, Prieto, Bryn A., additional, Kohler-Smith, Anna, additional, Díaz, Karina Gonzales, additional, Escudero, Magaly Figueredo, additional, Cuadro, Daniel Lenin del, additional, Aguila, Giannina Vásquez del, additional, Grandez, Henrry Daza, additional, Meza, Graciela, additional, Tracy, J. Kathleen, additional, Gravitt, Patti E., additional, Paz‑Soldan, Valerie A., additional, and Group, The Proyecto Precancer Study, additional

Published
2023
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21. Human papillomavirus infection and increased risk of HIV acquisition. A systematic review and meta-analysis

Author

Houlihan, Catherine F, Larke, Natasha L, Watson-Jones, Deborah, Smith-McCune, Karen K, Shiboski, Stephen, Gravitt, Patti E, Smith, Jennifer S, Kuhn, Louise, Wang, Chunhui, and Hayes, Richard

Subjects
Cervical Cancer, HPV and/or Cervical Cancer Vaccines, Prevention, Sexually Transmitted Infections, Cancer, Infectious Diseases, HIV/AIDS, Immunization, Vaccine Related, Aetiology, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Alphapapillomavirus, Female, HIV Seropositivity, Health Knowledge, Attitudes, Practice, Humans, Incidence, Male, Papillomavirus Infections, Risk Factors, Sexual Behavior, HIV, human papillomavirus, meta-analysis, papillomavirus infections, risk factors, Biological Sciences, Medical and Health Sciences, Psychology and Cognitive Sciences, Virology
Abstract

ObjectivesHuman papillomavirus (HPV), one of the commonest sexually transmitted infections, may be a cofactor in HIV acquisition. We systematically reviewed the evidence for an association of HPV infection with HIV acquisition in women, heterosexual men and men who have sex with men (MSM).Design: Systematic review and meta-analysis.MethodsStudies meeting inclusion criteria in Pubmed, Embase and conference abstracts up to 29 July 2011 were identified. Random effects meta-analyses were performed to calculate summary hazard ratios (HR). Publication bias and statistical heterogeneity were evaluated and population attributable fractions (PAFs) calculated.ResultsEight articles were included, with previously unpublished data from five authors. Seven studies found an association between prevalent HPV and HIV acquisition. Risk of HIV acquisition in women doubled with prevalent HPV infection with any genotype [HR = 2.06 (95% CI = 1.44-2.94), I = 0%], although adjustment for confounders was often inadequate. The effect was similar for high-risk [HR = 1.99 (95% CI = 1.54-2.56), I = 8.4%] and low-risk [HR = 2.01 (95% CI = 1.27-3.20), I = 0%] HPV genotypes with weak evidence of publication bias (P = 0.06). Two studies in men were identified: both showed an association between HPV infection and HIV acquisition. Unpublished data from one of two studies in women indicated an association between genotypes targeted by HPV vaccines and HIV acquisition. PAFs for HIV attributable to infection with any HPV genotype ranged between 21 and 37%.ConclusionIf further studies validate the association between HPV infection and HIV acquisition, HPV vaccines may reduce HIV incidence in high HPV prevalence populations, in addition to preventing cervical cancer. HIV surveillance studies during implementation of HPV vaccine programmes are warranted.

Published
2012

30. Untreated cervical intraepithelial neoplasia grade 2 and subsequent risk of cervical cancer: population based cohort study.

Author

Dyhr Lycke, Kathrine, Kahlert, Johnny, Petersen, Lone Kjeld, Kamp Damgaard, Rikke, Li C. Cheung, Gravitt, Patti E., and Hammer, Anne

Subjects
TREATMENT of cervical intraepithelial neoplasia, PUBLIC health surveillance, CONFIDENCE intervals, AGE distribution, TIME, CERVICAL intraepithelial neoplasia, HEALTH outcome assessment, POPULATION geography, SEVERITY of illness index, RISK assessment, DESCRIPTIVE statistics, CERVIX uteri tumors, CYTOLOGY, RESIDENTIAL patterns, ODDS ratio, LONGITUDINAL method, DISEASE risk factors, DISEASE complications
Published
2023
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31. Diagnosis

Author

Toy, Eugene P., primary, Stoler, Mark H., additional, Gravitt, Patti E., additional, and Rose, Robert C., additional

Published
2019
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33. Data from A Pooled Analysis to Compare the Clinical Characteristics of Human Papillomavirus–positive and -Negative Cervical Precancers

Author

Castle, Philip E., primary, Pierz, Amanda J., primary, Adcock, Rachael, primary, Aslam, Shagufta, primary, Basu, Partha S., primary, Belinson, Jerome L., primary, Cuzick, Jack, primary, El-Zein, Mariam, primary, Ferreccio, Catterina, primary, Firnhaber, Cynthia, primary, Franco, Eduardo L., primary, Gravitt, Patti E., primary, Isidean, Sandra D., primary, Lin, John, primary, Mahmud, Salaheddin M., primary, Monsonego, Joseph, primary, Muwonge, Richard, primary, Ratnam, Samuel, primary, Safaeian, Mahboobeh, primary, Schiffman, Mark, primary, Smith, Jennifer S., primary, Swarts, Avril, primary, Wright, Thomas C., primary, Van De Wyngard, Vanessa, primary, and Xi, Long Fu, primary

Published
2023
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34. Supplemental Figures 1-2 from A Pooled Analysis to Compare the Clinical Characteristics of Human Papillomavirus–positive and -Negative Cervical Precancers

Author

Castle, Philip E., primary, Pierz, Amanda J., primary, Adcock, Rachael, primary, Aslam, Shagufta, primary, Basu, Partha S., primary, Belinson, Jerome L., primary, Cuzick, Jack, primary, El-Zein, Mariam, primary, Ferreccio, Catterina, primary, Firnhaber, Cynthia, primary, Franco, Eduardo L., primary, Gravitt, Patti E., primary, Isidean, Sandra D., primary, Lin, John, primary, Mahmud, Salaheddin M., primary, Monsonego, Joseph, primary, Muwonge, Richard, primary, Ratnam, Samuel, primary, Safaeian, Mahboobeh, primary, Schiffman, Mark, primary, Smith, Jennifer S., primary, Swarts, Avril, primary, Wright, Thomas C., primary, Van De Wyngard, Vanessa, primary, and Xi, Long Fu, primary

Published
2023
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35. Supplementary Data Legends from A Pooled Analysis to Compare the Clinical Characteristics of Human Papillomavirus–positive and -Negative Cervical Precancers

Author

Castle, Philip E., primary, Pierz, Amanda J., primary, Adcock, Rachael, primary, Aslam, Shagufta, primary, Basu, Partha S., primary, Belinson, Jerome L., primary, Cuzick, Jack, primary, El-Zein, Mariam, primary, Ferreccio, Catterina, primary, Firnhaber, Cynthia, primary, Franco, Eduardo L., primary, Gravitt, Patti E., primary, Isidean, Sandra D., primary, Lin, John, primary, Mahmud, Salaheddin M., primary, Monsonego, Joseph, primary, Muwonge, Richard, primary, Ratnam, Samuel, primary, Safaeian, Mahboobeh, primary, Schiffman, Mark, primary, Smith, Jennifer S., primary, Swarts, Avril, primary, Wright, Thomas C., primary, Van De Wyngard, Vanessa, primary, and Xi, Long Fu, primary

Published
2023
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38. Supplementary Data from Determinants of VIA (Visual Inspection of the Cervix After Acetic Acid Application) Positivity in Cervical Cancer Screening of Women in a Peri-Urban Area in Andhra Pradesh, India

Author

Vedantham, Haripriya, primary, Silver, Michelle I., primary, Kalpana, B., primary, Rekha, C., primary, Karuna, B.P., primary, Vidyadhari, K., primary, Mrudula, S., primary, Ronnett, Brigitte M., primary, Vijayaraghavan, K., primary, Ramakrishna, Gayatri, primary, Sowjanya, Pavani, primary, Laxmi, Shantha, primary, Shah, Keerti V., primary, and Gravitt, Patti E., primary

Published
2023
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