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127 results on '"Gray, Julian"'

1. ACI‐24 vaccine in adults with Down syndrome

Author

Rafii, Michael S, Mobley, William C, Skotko, Brian G, Sabbagh, Marwan N, Burke, Anna D, Yuan, Shauna, Rissman, Robert A, Chavez, Ronelyn, Delpretti, Saskia, Sol, Olivier, Beth, Greg, Gray, Julian JG, dos Santos, Antonio Melo, Hliva, Valerie, Vukicevic, Marija, Kosco‐Vilbois, Marie, Pfeifer, Andrea, and Feldman, Howard H

Subjects
Geriatrics, Clinical Sciences, Neurosciences
Published
2020

2. Are The Bells And Whistles Really Worth It?

Author

Gray, Julian

Subjects
Law firms -- Service enhancement -- Human resource management, Attorneys -- Compensation and benefits, Company personnel management, Business, international
Abstract

In recent months, several City law firms have announced eye-watering increases to the salaries of fresh-faced newly qualified solicitors. The current high-water mark appears to be £180,000 reportedly paid by [...]

Published
2024

3. Rimeporide as a first- in-class NHE-1 inhibitor: Results of a phase Ib trial in young patients with Duchenne Muscular Dystrophy

Author

Previtali, Stefano C., Gidaro, Teresa, Díaz-Manera, Jordi, Zambon, Alberto, Carnesecchi, Stephanie, Roux-Lombard, Pascale, Spitali, Pietro, Signorelli, Mirko, Szigyarto, Cristina Al-Khalili, Johansson, Camilla, Gray, Julian, Labolle, Delphine, Porte Thomé, Florence, Pitchforth, Jacqueline, Domingos, Joana, and Muntoni, Francesco

Published
2020
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5. 4. An innovative clinical trial designed to evaluate the effects of ACI‐24.060 in Alzheimer’s Disease and in Down syndrome (ABATE Study)

Author

Sol, Olivier, primary, Lê, Bénédicte, additional, Wagg, Jonathan, additional, Delpretti, Saskia, additional, Fiorini, Emma, additional, Vukicevic, Marija, additional, MacSweeney, Emer, additional, Borejko, Olga, additional, Aarsland, Dag, additional, Arús, Xavier Morató, additional, Boada, Mercè, additional, Matias‐Guiu, Jordi A, additional, Lleo, Alberto, additional, Fournier, Nicolas, additional, Valatsou, Elena, additional, Feige, Agnès, additional, Rongere, Julien, additional, Gray, Julian JG, additional, Hliva, Valerie, additional, Fortea, Juan, additional, Strydom, Andre, additional, Rafii, Michael S, additional, Kosco‐Vilbois, Marie, additional, Pfeifer, Andrea, additional, and Streffer, Johannes, additional

Published
2023
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7. Biomarker‐based development for optimized ACI‐24, a novel candidate vaccine for the treatment and prevention of Alzheimer’s disease

Author

Sol, Olivier, primary, Lê, Bénédicte, additional, Valatsou, Elena, additional, Delpretti, Saskia, additional, Rongere, Julien, additional, Vukicevic, Marija, additional, Gray, Julian JG, additional, Hliva, Valerie, additional, Kosco‐Vilbois, Marie, additional, Pfeifer, Andrea, additional, and Streffer, Johannes, additional

Published
2022
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8. Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome

Author

Rafii, Michael S., primary, Sol, Olivier, additional, Mobley, William C., additional, Delpretti, Saskia, additional, Skotko, Brian G., additional, Burke, Anna D., additional, Sabbagh, Marwan N., additional, Yuan, Shauna H., additional, Rissman, Robert A., additional, Pulsifer, Margaret, additional, Evans, Casey, additional, Evans, A. Carol, additional, Beth, Gregory, additional, Fournier, Nicolas, additional, Gray, Julian A., additional, dos Santos, Antonio Melo, additional, Hliva, Valerie, additional, Vukicevic, Marija, additional, Kosco-Vilbois, Marie, additional, Streffer, Johannes, additional, Pfeifer, Andrea, additional, and Feldman, Howard H., additional

Published
2022
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9. Effects on Decline or Deterioration

Author

Gauthier, Serge, Poirier, Judes, Gray, Julian, Giacobini, Ezio, editor, Becker, Robert, editor, Becker, Robert E., editor, Barton, Joyce M., editor, and Brown, Mona, editor

Published
1997
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12. ACI‐24 in adults with Down syndrome: Results of a phase 1b, randomized, placebo‐controlled study

Author

Rafii, Michael S, primary, Sol, Olivier, additional, Mobley, William C, additional, Skotko, Brian G., additional, Burke, Anna D, additional, Sabbagh, Marwan N., additional, Yuan, Shauna, additional, Rissman, Robert A., additional, Delpretti, Saskia, additional, Beth, Greg, additional, Gray, Julian JG, additional, Melo dos Santos, Antonio, additional, Hliva, Valerie, additional, Vukicevic, Marija, additional, Kosco‐Vilbois, Marie, additional, Streffer, Johannes, additional, Pfeifer, Andrea, additional, and Feldman, Howard, additional

Published
2021
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13. The 29th annual FM-MSA-TGMS Tucson Mineralogical Symposium classic mineral localities of the United States

Author

Gray, Julian and Cook, Robert B.

Subjects
Minerals -- Conferences, meetings and seminars, Scientific societies -- Conferences, meetings and seminars, United States history -- Conferences, meetings and seminars, Earth sciences
Abstract

INTRODUCTION The 29th Annual Tucson Mineralogical Symposium sponsored by the Mineralogical Society of America, Friends of Mineralogy, and the Tucson Gem and Mineral Society will be held on Saturday, February [...]

Published
2008

18. Allergen Microarrays

Author

Bacarese-Hamilton, Tito, primary, Gray, Julian, additional, Ardizzoni, Andrea, additional, and Crisanti, Andrea, additional

Published
2005
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19. Rimeporide as a first- in-class NHE-1 inhibitor : Results of a phase Ib trial in young patients with Duchenne Muscular Dystrophy

Author

Previtali, Stefano C., Gidaro, Teresa, Diaz-Manera, Jordi, Zambon, Alberto, Carnesecchi, Stephanie, Roux-Lombard, Pascale, Spitali, Pietro, Signorelli, Mirko, Al-Khalili Szigyarto, Cristina, Johansson, Camilla, Gray, Julian, Labolle, Delphine, Thome, Florence Porte, Pitchforth, Jacqueline, Domingos, Joana, Muntoni, Francesco, Previtali, Stefano C., Gidaro, Teresa, Diaz-Manera, Jordi, Zambon, Alberto, Carnesecchi, Stephanie, Roux-Lombard, Pascale, Spitali, Pietro, Signorelli, Mirko, Al-Khalili Szigyarto, Cristina, Johansson, Camilla, Gray, Julian, Labolle, Delphine, Thome, Florence Porte, Pitchforth, Jacqueline, Domingos, Joana, and Muntoni, Francesco

Abstract

Rimeporide, a first-in-class sodium/proton exchanger Type 1 inhibitor (NHE-1 inhibitor) is repositioned by EspeRare for patients with Duchenne Muscular Dystrophy (DMD). Historically, NHE-1 inhibitors were developed for cardiac therapeutic interventions. There is considerable overlap in the pathophysiological mechanisms in Congestive Heart Failure (CHF) and in cardiomyopathy in DMD, therefore NHE-1 inhibition could be a promising pharmacological approach to the cardiac dysfunctions observed in DMD. Extensive preclinical data was collected in various animal models including dystrophin-deficient (mdx) mice to characterise Rimeporide's anti-fibrotic and anti-inflammatory properties and there is evidence that NHE-1 inhibitors could play a significant role in modifying DMD cardiac and also skeletal pathologies, as the NHE-1 isoform is ubiquitous. We report here the first study with Rimeporide in DMD patients. This 4-week treatment, open label phase Ib, multiple oral ascending dose study, enrolled 20 ambulant boys with DMD (6-11 years), with outcomes including safety, pharmacokinetic (PK) and pharmacodynamic (PD) biomarkers. Rimeporide was safe and well-tolerated at all doses. PK evaluations showed that Rimeporide was well absorbed orally reaching pharmacological concentrations from the lowest dose, with exposure increasing linearly with dose and with no evidence of accumulation upon repeated dosing. Exploratory PD biomarkers showed positive effect upon a 4-week treatment, supporting its therapeutic potential in patients with DMD, primarily as a cardioprotective treatment, and provide rationale for further efficacy studies., QC 20201007

Published
2020
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21. Energy law challenges in the Middle East

Author

Gray, Julian and Hyde, Sarah

Subjects
Middle East -- Energy policy, Energy policy -- Analysis, Business, Business, international, Economics, Petroleum, energy and mining industries
Abstract

IT IS without question that the discovery of oil and gas in the Middle East has dramatically changed the domestic lifestyle and commercial importance of the region. With about two-thirds [...]

Published
1992

22. Regional variations

Author

Gray, Julian and Egerton-Smith, Rupert

Subjects
Regional economics -- Analysis, Infrastructure (Economics) -- Europe, Manufacturing industry -- Analysis, Business, Engineering and manufacturing industries, Science and technology, European Union
Abstract

The European Union (EU) is subdivided into more than 150 economic regions, each with its own set of parameters which have significant impact on the shape of manufacturing in Europe. The development of manufacturing will continue to be fragmented within the European Union as long as the variations in national policies continue to exist. Many other factors such as the regional economy, and utilities and transportation infrastructure also affect the manufacturing process. Importance is given to high technology industries in all EU nations.

Published
1996

23. Mertz, Volume 1: Character Pieces: Intermediate Classical Guitar Folio

Author

Mertz, Johann Kaspar, Gray, Julian, Mertz, Johann Kaspar, and Gray, Julian

Abstract

Classical guitarists---both students and professional performers---require the same high-quality editions that their pianist colleagues have come to expect from Alfred Music. Our Classical Guitar Masterworks Editions continue the Alfred Music tradition of providing carefully edited, beautifully presented music for practice and performance. This edition of Mertz's character pieces includes 28 pieces from Bardenklänge, Op. 13, as well as Trois Nocturnes, Op. 4. Mertz's most important body of work was Bardenklänge, which features many small but delightful pieces. Included here are often-performed works like'Liebeslied,''Tarantelle,''An Malvina,'and'Romanze,'which clearly affirm Mertz's places as the guitar's principal German Romantic composer. The attractive Three Nocturnes, Op. 4 are popular recital pieces and will be a great addition to your repertoire. This masterwork edition features thoughtful, expert fingerings by respected performer and pedagogue Julian Gray. It is a must-have for any serious classical guitarist. Titles:• Bardenklänge, Op. 13 • An Malvina (To Malvina) • Romanze • Abendlied (Evening Song) • Unruhe (Restlessness) • Elfenreigen (Dance of the Elves) • An die Entfernte (To the Distant One) • Etude • Capriccio • Gondoliera • Liebeslied (Love Song) • Fingals-Höhle (Fingal's Cave) • Gebeth (Prayer) • Tarantelle • Variations mignonnes • Kindermärchen (Children's Fairy Tale) • Rondino • Romanze • Scherzo • Sehnsucht (Longing) • Lied ohne Worte (Song without Words) • Mazurka • Polonaises Favorites 1, 2, 3 & 4 • Polonaises Favorites 4, 5 & 6 • Trois Nocturnes, Op. 4

Published
2015

25. Letters

Author

Skalwold, Elise, primary, Scanlon, Adam, additional, Gray, Julian C., additional, and Jacobson, Mark Ivan, additional

Published
2016
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26. PET Imaging and Neurodegenerative Diseases.

Author

Kroth, Heiko and Gray, Julian J. G.

Subjects
THERAPEUTIC use of monoclonal antibodies, BRAIN, BIOMARKERS, PROTEINS, STATISTICS, ALZHEIMER'S disease, MAGNETIC resonance imaging, POSITRON emission tomography, PARKINSON'S disease, SINGLE-photon emission computed tomography, CEREBROSPINAL fluid, DATA analysis, ROUTINE diagnostic tests, NEURODEGENERATION, EARLY diagnosis
Published
2023

29. Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3

Author

Guiyedi, Vincent, primary, Bécavin, Christophe, additional, Herbert, Fabien, additional, Gray, Julian, additional, Cazenave, Pierre-André, additional, Kombila, Maryvonne, additional, Crisanti, Andrea, additional, Fesel, Constantin, additional, and Pied, Sylviane, additional

Published
2015
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30. Letters

Author

Gray, Julian C., primary and Bornhorst, Theodore J., additional

Published
2015
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35. Letter to the Editor

Author

Gray, Julian C., primary, Smith, Jeff, additional, Betts, John H., additional, and Collins, Marge, additional

Published
2014
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37. What are smart meters? [Fact sheet]

Author

Aravinthan, Vasantha, Ho, Goen, Gray, Julian, Butler, Reid, Connell, Damien, Aravinthan, Vasantha, Ho, Goen, Gray, Julian, Butler, Reid, and Connell, Damien

Abstract

The saying 'if you can't measure it, you can't manage it' may suffer from overuse, but rarely is it an inaccurate observation. Australia, being the driest continent in the world, suffers from periodic drought conditions that make water availability a key national issue. Water utilities and industries around Australia have been under growing pressure to address water shortages caused by population growth, severe droughts, and uneven distribution of water resources caused by climatic changes. Ever-increasing water demands coupled with dwindling water supplies have posed great challenges to water industries to seriously consider the efficient management of water resources. After decades of inadequate metering of water use, organisations have realised that accurate, adequate and reliable measurement and monitoring practices of water consumption are essential for management of sustainable water resources (Willies et al., 2010). This fact sheet provides information on current measurement methods adopted by utilities and technological improvement and innovation that occurs in this field.

Published
2012

38. Letters

Author

Houran, Jim, primary, Gray, Julian C., additional, and Collins, Marge, additional

Published
2013
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42. Amethyst and associated minerals from Jacksons Crossroads, Wilkes County, Georgia

Author

Cook, Robert B., Ledford, Terry, and Gray, Julian C.

Subjects
Georgia -- Natural resources, Amethysts -- Discovery and exploration, Earth sciences
Abstract

The spectacular amethyst specimens and gem rough being mined commercially from near Jacksons Crossroads in Wilkes County, east-central Georgia, may well be the finest ever produced in the United States. [...]

Published
2008

43. Rutile, lazulite and associated minerals from Graves Mountain, Lincoln County, Georgia

Author

Cook, Robert B., Gray, Julian C., Santamaria, Jose E., and Gordon, Jennings B.

Subjects
Georgia -- Natural resources, Rutile -- Discovery and exploration, Earth sciences
Abstract

Graves Mountain in Lincoln County, Georgia, is certainly one of America's most prolific mineral localities, known around the world for its unsurpassed rutile specimens, an abundance of fine lazulite, and [...]

Published
2008

47. Efficacy and Safety of Donepezil in the Treatment of Parkinson's Disease Patients With Dementia

Author

Dubois, Bruno, primary, Tolosa, Eduardo, additional, Kulisevsky, Jaime, additional, Reichmann, Heinz, additional, Jones, Roy W., additional, Burn, David J., additional, Harre, Mark, additional, Thomas, Gail, additional, Harris, Ray, additional, Moline, Margaret, additional, Silver, Gabrielle, additional, Swartz, Jina E., additional, Schindler, Rachel, additional, and Gray, Julian, additional

Published
2007
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48. Allergen Microarrays.

Author

Walker, John M., Joos, Thomas O., Fortina, Paolo, Bacarese-Hamilton, Tito, Gray, Julian, Ardizzoni, Andrea, and Crisanti, Andrea

Abstract

Allergy affects more than 25% of Western populations (1) and is estimated to be the sixth leading cause of chronic disease in the United States and Western Europe. The complexity of the condition is such that hundreds of common allergens have been described, and in order to maximize diagnostic efficiency there is an urgent clinical requirement for assays to provide multiple-allergen determination in a timely and cost-effective manner. Miniaturized immunoassays that utilize protein microarray technology now offer the possibility of circumventing most of the current limitations in the serodiagnosis of allergic disease. The heterogeneous nature of allergens presents many challenges in all aspects of developing such arrays, from immobilization of the capture molecule to detection of the bound ligand. In addition, there is no simple method of protein amplification (such as PCR for nucleic acids), and stabilization is yet a further major consideration. Notwithstanding these challenges, protein microarrays have been developed for the serodiagnosis of allergies and other complex clinical conditions. These assays exhibit good analytical and clinical performance and deliver significant advantages in convenience and cost compared with traditional ELISA test formats. This chapter details the techniques employed in the construction and processing of an allergen array specific for the serodiagnosis of allergic disease. An overview of protein microarray technology is provided and the principles that underpin the suitability for use of this technology in the identification and measurement of particular proteins in patient sera (serum profiling) are discussed. [ABSTRACT FROM AUTHOR]

Published
2005
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49. Protein Arrays for Serodiagnosis of Disease.

Author

Walker, John M., Fung, Eric T., Bacarese-Hamilton, Tito, Ardizzoni, Andrea, Gray, Julian, and Crisanti, Andrea

Abstract

Protein microarrays offer the possibility to circumvent most of the current limitations in the serodiagnosis of allergy, autoimmune, and infectious disease by allowing the simultaneous, multiparametric determination of specific subclasses of antibodies directed against many pathogenic antigens. Microarray immunoassays have been developed with these characteristics. A first-generation assay, for the serodiagnosis of infectious disease, allows the determination of IgG and IgM antibodies to various viral and bacterial antigens. In addition, a second-generation assay, designed for the serodiagnosis of allergic disease, permits the determination of IgE antibodies to various allergens implicated in allergic disease. Slides printed with antibody dilution curves and antigen are first incubated with serum samples and then subsequently with secondary antibodies. For detection of human IgG and IgM, fluorescently labeled secondary antibodies are employed. However, because of low-level concentrations of circulating IgE antibodies, a more sensitive protocol is required for human IgE detection. Here, fluorescence is delivered via the coupling of the secondary antibody to tyramide signal-amplification reagentry. Human IgG, IgM, or IgE bound to the printed antigens can then be revealed by confocal scanning microscopy and quantified with internal calibration curves. Generation of analytical and clinical data have demonstrated that the microarray test format provides equivalent performance to enzyme-linked immunosorbent assay (ELISA) tests and offers a significant advantage in convenience and cost when compared to traditional test formats. [ABSTRACT FROM AUTHOR]

Published
2004
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