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1. Hepatic tumors: pitfalls in diagnostic imaging

Author

Grazzini G., Cozzi D., Flammia F., Grassi R., Agostini A., Belfiore M. P., Borgheresi A., Mazzei M. A., Floridi C., Carrafiello G., Giovagnoni A., Pradella S., Miele V., Grazzini, G., Cozzi, D., Flammia, F., Grassi, R., Agostini, A., Belfiore, M. P., Borgheresi, A., Mazzei, M. A., Floridi, C., Carrafiello, G., Giovagnoni, A., Pradella, S., and Miele, V.

Subjects
focal nodular hyperplasia, Carcinoma, Hepatocellular, hepatocellular adenoma, Liver Neoplasms, food and beverages, Review, hepatocellular carcinoma, Magnetic Resonance Imaging, digestive system diseases, Hepatocellular tumor, Diagnosis, Differential, Humans, hepatocellular tumors, Hepatocel-lular carcinoma, CT, MRI
Abstract

On computed tomography (CT) and magnetic resonance imaging (MRI), hepatocellular tumors are characterized based on typical imaging findings. However, hepatocellular adenoma, focal nodular hyper-plasia, and hepatocellular carcinoma can show uncommon appearances at CT and MRI, which may lead to diagnostic challenges. When assessing focal hepatic lesions, radiologists need to be aware of these atypical imaging findings to avoid misdiagnoses that can alter the management plan. The purpose of this review is to illustrate a variety of pitfalls and atypical features of hepatocellular tumors that can lead to misinterpretations providing specific clues to the correct diagnoses. (www.actabiomedica.it).

Published
2020

2. Diagnostic protocols in oncology: workup and treatment planning. Part 1: the optimitation of CT protocol

Author

Granata, V., Fusco, R., Bicchierai, G., Cozzi, D., Grazzini, G., Danti, G., DE MUZIO, F., Maggialetti, N., Smorchkova, O., D'Elia, M., Brunese, M. C., Grassi, R., Giacobbe, G., Bruno, F., Palumbo, P., Lacasella, G. V., Brunese, L., Miele, V., Barile, A., Granata, V., Fusco, R., Bicchierai, G., Cozzi, D., Grazzini, G., Danti, G., DE MUZIO, F., Maggialetti, N., Smorchkova, O., D'Elia, M., Brunese, M. C., Grassi, R., Giacobbe, G., Bruno, F., Palumbo, P., Lacasella, G. V., Brunese, L., Miele, V., and Barile, A.

Subjects
Abbreviated protocol, Computed tomography, Magnetic resonance study, Oncologic imaging, Radiation exposure, Humans, Medical Oncology, Neoplasms, Tomography, X-Ray Computed, Tomography, X-Ray Computed
Abstract

The increase in oncology knowledge and the possibility of creating personalized medicine by selecting a more suitable therapy related to tumor subtypes, as well as the patient's management with cancer within a multidisciplinary team has improved the clinical outcomes. Early detection of cancer through screening-based imaging is probably the major contributor to a reduction in mortality for certain cancers. Nowadays, imaging can also characterize several lesions and predict their histopathological features and can predict tumor behaviour and prognosis. CT is the main diagnostic tool in oncologic imaging and is widely used for the tumors detection, staging, and follow-up. Moreover, since CT accounts for 49-66% of overall patient radiation exposure, the constant reduction, optimization, dose inter- and intraindividual consistency are major goals in radiological field. In the recent years, numerous dose reduction techniques have been established and created voltage modulation keeping a satisfactory image quality. The introduction of CT dual- layer detector technology enabled the acquisition of spectral data without additional CT x-ray tube or additional acquisitions. In addition, since MRI does not expose the body to radiation, it has become a mainstay of non-invasive diagnostic radiology modality since the 1980s.

Published
2021

5. Technological advances in body CT: a primer for beginners.

Author

AGOSTINI, A., BORGHERESI, A., GRANATA, V., BRUNO, F., PALUMBO, P., DE MUZIO, F., BICCI, E., GRAZZINI, G., GRASSI, F., FUSCO, R., BARILE, A., MIELE, V., and GIOVAGNONI, A.

Abstract

Many technological advances have entered the clinical routine of Computed Tomography (CT) imaging. The new CT scanners have specific solutions in gantry design to bear the mechanical solicitations. The X-ray tubes have been improved for faster acquisitions at low radiation exposure, while the innovations in CT detectors provide a better image quality. The optimization of image quality and contrast, and the reduction of radiation dose, cannot be achieved without the implementation of adequate reconstruction software, such as Iterative Reconstructions (IR) and Artificial Intelligence (AI). In recent years, dual-energy (DECT) technology has expanded the indications of CT. In this narrative review, a panoramic overview of the technological novelties in CT imaging will be provided for optimal utilization of CT technology. [ABSTRACT FROM AUTHOR]

Published
2022

10. Non-traumatic non-cardiovascular thoracic emergencies: role of imaging.

Author

BICCI, E., GRAZZINI, G., COZZI, D., DANTI, G., PRADELLA, S., PALUMBO, P., BRUNO, F., GRASSI, F., DELL’ AVERSANA, F., DE MUZIO, F., BRUNESE, M. C., CUTOLO, C., FUSCO, R., GRANATA, V., GIOVAGNONI, A., and MIELE, V.

Abstract

Patients presenting to the emergency with thoracic symptoms could have a wide variety of causes, even if the traumatic and vascular causes are excluded. Therefore, the diagnosis is often a challenge for emergency physicians. Anamnesis, physical examination and laboratory testing need to be integrated with imaging to get a rapid diagnosis and to distinguish among the potential causes. This review discusses the role of diagnostic imaging studies in the emergency setting in patients with non-traumatic non-cardiovascular thoracic symptoms. The use of chest x-ray, bedside lung Ultrasound and Computed Tomography in the diagnosis and care of these patients have been reviewed as well as the common findings on imaging. [ABSTRACT FROM AUTHOR]

Published
2022

11. Radiological assessment of peritoneal carcinomatosis: a primer for resident.

Author

GRANATA, V., FUSCO, R., SETOLA, S. VENANZIO, SASSAROLI, C., DE FRANCISIS, S., DELRIO, P., DANTI, G., GRAZZINI, G., FAGGIONI, L., GABELLONI, M., OTTAIANO, A., GREGGI, S., PATRONE, R., PALAIA, R., PETRILLO, A., and IZZO, F.

Abstract

The imaging has critical responsibility in the assessment of peritoneal lesions along with estimating the overall extent. Valuing disease burden is crucial for selection of combining cytoreductive surgery (CRS) and intraperitoneal hyperthermic chemotherapy (HIPEC) treatment. An approach that combines the strength of several imaging tools and increases diagnostic accuracy, should be chosen, even if the preferred imaging tool in patients with suspected Peritoneal Carcinomatosis (PC) is CT. The outcomes of PC are mainly correlated to tumor spread, localization, and lesion size. Accurate assessment of these features is critical for prognosis and treatment planning. These data can be evaluated by Peritoneal Cancer Index (PCI), a quantitative index suggested by Harman and Sugarbaker. Additionally, precise predictive biomarkers should be established to predict PC in patients at risk. The radiomics analysis could predict PC throughout the evaluation of cancers heterogeneity. [ABSTRACT FROM AUTHOR]

Published
2022

13. Sustainability and information in urban system analysis

Author

Baloccoa, C. and Grazzini, G.

Subjects
Energy conservation -- Methods, Energy conservation -- Analysis, Energy conservation -- United States, Metropolitan areas -- Energy use, Business, Environmental issues, Petroleum, energy and mining industries
Abstract

The process of applying information theory for analyzing new energy saving systems in urban areas is presented.

Published
2006

17. Diagnostic performance of LI-RADS in adult patients with rare hepatic tumors.

Author

GRANATA, V., FUSCO, R., SETOLA, S. VENANZIO, BARRETTA, M. L., IASEVOLI, D. M. A., PALAIA, R., BELLI, A., PATRONE, R., TATANGELO, F., GRAZZINI, G., GRASSI, R., GRASSI, F., ANSELMO, A., IZZO, F., and PETRILLO, A.

Abstract

OBJECTIVE: The rare hepatic tumor can have a wide spectrum of radiologic features, representing a diagnostic challenge. Our purpose is to report the experience of a National Cancer Center, emphasizing the radiological features encountered and assessing the LR-M categories in the diagnostic performances for these lesions. PATIENTS AND METHODS: We assessed 113 patients who underwent surgical resection or biopsy for rare liver lesions from May 2010 to December 2020. For these patients a computerized search of radiological records was performed to identify which had been studied with MRI and CT. For each lesion, the radiologists recorded the attenuation on CT studies and signal intensity (SI) in T1 weighted (W), in T2-W, DWI and in the related map of the apparent diffusion coefficient (ADC). We assessed the presence and the type of contrast enhancement (CE) during contrast study on CT and MRI and the enhancement was categorized according to LI-RADS 2018. We also assessed the presence of other features in LR-M categories (ancillary LR-M features) in order to classify different subgroups. The lesions were classified according to LR categories, and the gold standard was histological analysis. RESULTS: The final study population included 95 patients (46 females and 49 males), with a mean age of 51 years (range 38-83 years). 83 patients had solid lesions, 12 patients had cystic lesions (simple or complex). According to histological analysis, we categorized 79 patients with malignant lesions and 16 patients with benign lesions. According to radiological features we assessed as malignant 82 patients (79 true malignant and 3 false malignant), as benign 13 patients (all true benign). Therefore, sensitivity, specificity, positive predictive value, negative predictive value and accuracy of radiological features to identify benign and malignant lesions were 100.0%, 81.3%, 96.3%, 100.0% and 96.8%, respectively. We found no significant difference in signal and contrast enhancement appearance among all LR-M categories (p-value =0.34 at Chi square test). However, among LR-M categories the presence of satellite nodules was a feature typical of cHCC-CC (p-value < 0.05 at Chi square test). The presence of intra lesion necrosis and haemorrhage was suggestive of sarcoma (p-value < 0.05 at Chi square test). CONCLUSIONS: High diagnostic accuracy was obtained by LI-RADS classification between malignant and benign lesion. The presence of ancillary features could help the radiologist towards a correct diagnosis. [ABSTRACT FROM AUTHOR]

Published
2022

19. Blood collection and processing. Quality guidelines and standards reflecting common best practice standards referring to the EuBIS manual and guide

Author

Seidl, C., Huber, H. M., Müller-Kuller, T., Sireis, W., Aquilina, A., Barotine-Toth, K., Cardenas, J. M., Ceulemans, J., Cermakova, Z., Delaney, F., Jansen van Galen, J. P., Grazzini, G., Hinloopen, B., Heiden, M., Nightingale, M., Pupella, S., Sobaga, L., Teskrat, F., deWit, J., and Seifried, E.

Published
2012
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21. Deferral of males who had sex with other males

Author

Benjamin, R. J., Bianco, C., Goldman, M., Seed, C. R., Yang, H., Lee, J., Keller, A. J., Wendel, S., Biagini, S., Murray, J., Devine, D. V., Zhu, Y., Turek, P., Moftah, F. M., Kullaste, R., Pillonel, J., Danic, B., Bigey, F., Folléa, G., Seifried, E., Mueller, M. M., Lin, C. K., Makroo, R. N., Grazzini, G., Pupella, S., Velati, C., Tadokoro, K., Lindoro, A. Bravo, González, A. DʼArtote, Giner, V. T., Flanagan, P., Olaussen, R. W., Letowska, M., Rosiek, A., Poglod, R., Zhiburt, E., Mali, P., Rozman, P., Gulube, S., Izaguirre, E. Castro, Ekermo, B., Barnes, S. M., McLaughlin, L., Eder, A. F., Panzer, S., and Reesink, H. W.

Published
2011
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26. Research and development

Author

Devine, D. V., Reesink, H. W., Panzer, S., Irving, D. O., Körmöczi, G. F., Mayr, W. R., Blais, Y., Zhu, Y., Qian, K., Zhu, Z., Greinacher, A., Grazzini, G., Pupella, S., Catalano, L., Vaglio, S., Liumbruno, G. M., Smeenk, J. W., Josemans, E. A. J., Briët, E., Letowska, M., Lachert, E., Antoniewicz-Papis, J., Brojer, E., Gulliksson, H., Scott, M., Williamson, L, Prowse, C., AuBuchon, J. P., López, J. A., Hoffman, P., Busch, M. P., Norris, P. J., Tomasulo, P., and Dodd, R. Y.

Published
2010
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28. Haemovigilance for the optimal use of blood products in the hospital

Author

Reesink, H. W., Panzer, S., Gonzalez, C. A., Lena, N., Muntaabski, P., Gimbatti, S., Wood, E., Lambermont, M., Deneys, V., Sondag, D., Alport, T., Towns, D., Devine, D., Turek, P., Auvinen, M. K., Koski, T., Lin, C. K., Lee, C. K., Tsoi, W. C., Lawlor, E., Grazzini, G., Piccinini, V., Catalano, L., Pupella, S., Kato, H., Takamoto, S., Okazaki, H., Hamaguchi, I., Wiersum-Osselton, J. C., van Tilborgh, A. J. W., Zijlker-Jansen, P. Y., Mangundap, K. M., Schipperus, M. R., Dinesh, D., Flanagan, P., Flesland, Ø., Steinsvåg, C. T., Espinosa, A., Letowska, M., Rosiek, A., Antoniewicz-Papis, J., Lachert, E., Koh, M. B. C., Alcantara, R., Alonso, Corral M., and Muñiz-Diaz, E.

Published
2010
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32. West Nile Virus in Italy: SP418

Author

Liumbruno, G M, Catalano, L, Pupella, S, Piccinini, V, Calizzani, G, Pascarelli, N, Randi, V, Silvestri, A, Zucchelli, P, and Grazzini, G

Published
2009

38. Diagnostic protocols in oncology: workup and treatment planning. Part 2: Abbreviated MR protocol.

Author

GRANATA, V., BICCHIERAI, G., FUSCO, R., COZZI, D., GRAZZINI, G., DANTI, G., DE MUZIO, F., MAGGIALETTI, N., SMORCHKOVA, O., D'ELIA, M., BRUNESE, M. C., GRASSI, R., GIACOBBE, G., BRUNO, F., PALUMBO, P., GRASSI, F., BRUNESE, L., MIELE, V., and BARILE, A.

Abstract

Magnetic resonance imaging (MRI) is a non-invasive imaging technique (non-ionizing radiation) with superior soft tissue contrasts and potential morphological and functional applications. However, long examination and interpretation times, as well as higher costs, still represent barriers to MRI use in clinical routine. Abbreviated MRI protocols have emerged as an alternative to standard MRI protocols. Abbreviated MRI protocols eliminate redundant sequences that negatively affect cost, acquisition time, patient comfort. However, the diagnostic information is generally not compromised. Abbreviated MRI protocols have already been utilized for hepatocellular carcinoma, for prostate cancer detection, and for nonalcoholic fatty liver disease screening. [ABSTRACT FROM AUTHOR]

Published
2021

39. Cord blood banking

Author

Brand, A., Rebulla, P., Engelfriet, C. P., Reesink, H. W., Beguin, Y., Baudoux, E., Kögler, G., Ebrahimi, M., Grazzini, G., Costa, A. Nanni, Bosi, A., Sacchi, N., Lombardini, L., Pupella, S., Lecchi, L., Calderón Garcidueñas, E. D., van Beckhoven, J. M., de Wit, H. J. C., Fibbe, W. E., Zhiburt, E. B., Bart, T., Beksaç, M., Navarrete, C., and Regan, F.

Published
2008

40. Prevalence, incidence and residual risk of transfusion-transmitted hepatitis B virus infection in Italy from 2009 to 2018

Author

Velati, C., Romano, L., Pati, I., Marano, G., Piccinini, V., Catalano, L., Pupella, S., Vaglio, S., Veropalumbo, E., Masiello, F., Pisani, G., Grazzini, G., Zanetti, A., and Liumbruno, G. M.

Subjects
Adult, Male, Adolescent, Incidence, Blood Safety, Haemovigilance, HBV, Prevalence, Residual risk, Aged, Female, Humans, Italy, Middle Aged, Polymerase Chain Reaction, Blood Donors, Hepatitis B, Transfusion Reaction
Published
2019

43. Basic variables at different positivity thresholds of a quantitative immunochemical test for faecal occult blood. (Original Paper)

Author

Castiglione, G., Grazzini, G., Miccinesi, G., Rubeca, T., Sani, C., Turco, P., and Zappa, M.

Subjects
Physical diagnosis -- Methods -- Usage -- Health aspects -- Analysis, Medical tests -- Analysis -- Usage -- Methods -- Health aspects, Cancer -- Diagnosis, Periodic health examinations -- Methods -- Usage -- Health aspects -- Analysis, Colorectal cancer -- Demographic aspects -- Health aspects -- Diagnosis -- Prevention, Health, Social sciences, Practice, Diagnosis, Prevention, Analysis, Usage, Demographic aspects, Methods, Health aspects
Abstract

Objectives: Screening by faecal occult blood testing (FOBT) is effective in decreasing mortality and incidence of colorectal cancer (CRC). Immunochemical tests have proved to be more cost effective than guaiac [...]

Published
2002

44. A cost analysis of public cord blood banks belonging to the Italian cord blood network

Author

Pupella, S., Bianchi, M., Ceccarelli, A., Calteri, D., Lombardini, L., Giornetti, A., Marano, G., Franchini, M., Grazzini, G., and Liumbruno, G. M.

Subjects
banking, cord blood, cost analysis, costs, stem cell transplantation, blood banks, blood preservation, costs and cost analysis, cryopreservation, humans, Italy, blood donors, fetal blood
Published
2018

46. Standard di Medicina Trasfusionale

Author

Grazzini, G., Berti, Patrizio, Boccagni, P., Bonini, R., Fiorin, F., Gandini, G., and Menichini, I.

Subjects
Standard di Medicina Trasfusionale
Published
2017

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