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Among patients with migraine who use prescription medications, the increasing use of prescription opioids is associated with chronic migraine, more severe disability, and anxiety and depression, according to an analysis [...]

Among children with persistent post-concussion symptoms, poor recovery at 10 weeks is associated with higher cerebral blood flow at 4-6 weeks, according to a study presented at the 2020 CNS-ICNA [...]

Inpatient and outpatient treatments of transient ischemic attack (TIA) or minor ischemic stroke (mIS) yield comparable safety outcomes, new research suggests. In a meta-analysis of more than 200,000 patients with [...]

DIABETES MELLITUS (DM) is as sociated with Parkinson's disease (PD) development, as well as more severe symptoms and more rapid disease progression, new research suggests. In a systematic review, patients [...]

About half of children with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) have new-onset neurologic symptoms, research shows. These symptoms involve the central and peripheral nervous systems but [...]

Because of the complexity of the manufacturing processes for biologies, transfer of these processes to a contract manufacturer presents challenges. BioPharm International asked representatives of leading CMOs about these challenges, [...]

Platform technology is becoming a popular industry approach for bioprocessing, but just how are companies using it? Pharmaceutical Technology talked to industry experts to gain insight: Morrey Atkinson, PhD, CSO [...]

The oral delivery of biopharmaceuticals is highly desirable because it would provide ease of administration and improve patient compliance. But oral administration remains an elusive goal in biopharmaceutical drug delivery. [...]

Sustained-release injectable biologics are popular among patients who suffer chronic illnesses. Injectable products that offer controlled drug release can reduce the frequency of injections, which makes it easier for patients [...]

Money is tight in our weakened economy, and biopharmaceutical companies in particular, most of which are new firms that depend on investor capital, are feeling the pinch. Consequently, the contract [...]

Methods that detect microbial contamination more quickly than traditional techniques have long been available. Despite the high sensitivity, great accuracy, and quick results of the rapid techniques, the pharmaceutical and [...]

REPORTING FROM AAD 2019 WASHINGTON -- Many patients with vitiligo are interested in treating their condition with vitamins, supplements, or a modified diet, but research on whether these measures have [...]

Late-onset epilepsy is linked to a substantial increased risk of subsequent dementia. Results of a retrospective analysis show that patients who develop epilepsy at age 67 or older have a [...]

The mortality burden associated with dementia may be 2.7 times greater than estimated, according to an analysis of a prospective cohort study. This burden may be greatest among non-Hispanic Black [...]

Drugmakers rely on automated equipment as a matter of course. Yet unlike the food and semiconductor industries, the pharmaceutical industry has been slow to adopt one particular form of automation: [...]

Dosage forms that contain more than one active pharmaceutical ingredient (API) can improve patient compliance and facilitate the treatment of certain diseases. Strategies to control the release of APIs in [...]

Debates about science, manufacturing, and European regulations will shape the approval process for follow-on biologics in the United States. Biopharmaceuticals represent a growing proportion of medicines in development and of [...]

Although sectors such as the automotive industry adopted just-in-time (JIT) manufacturing principles long ago, pharmaceutical and biopharmaceutical companies have been slow to embrace them. Now, faced with increased pressure to [...]

The pharmaceutical industry is a fairly old industry, and as such, the modern manufacturing facility really reflects an evolution--the aggregate of incremental changes. For example, the plant today is far [...]

Pharmaceutical companies that face dwindling new-drug pipelines are pursuing new delivery methods for their drug products. One strategy is to develop respiratory delivery techniques for drugs that are now administered [...]

Outsourcing clinical-trial materials (CTM) is strong and growing. Because of significant cost pressures and the globalization of clinical research activities, pharmaceutical companies are hiring contract manufacturing organizations (CMOs) to provide [...]

Pharmaceutical Technology's Second Annual Manufacturers' Rankings reveal key trends about the pharmaceutical industry's sales growth, product and company positioning, and the manufacturing activity of the top companies. Led by a [...]

Pharmaceutical Technology provides perspective on pharmaceutical manufacturing activity, assessing the product portfolios, prescription volumes, revenues, and capital spending plans of more than 500 drug-makers. Novartis leads in diversity, with 889 [...]

WASHINGTON--A novel, standardized preparation of topical cantharidin effectively cleared lesions in patients with molluscum contagiosum, compared with placebo, according to the results of two trials presented at the annual meeting [...]

FROM NEUROLOGY The American Academy of Neurology has issued a new guideline for the treatment of sleep problems in children and teenagers with autism spectrum disorders (ASD). The guideline was [...]

CHARLOTTE, N.C. -- Fetal MRI and consultation with a neurologist make significant contributions to the fetal diagnosis of posterior fossa anomalies, according to research presented at the annual meeting of [...]

The market for vaccines is expanding, thanks partly to the discovery of new biologics and to public-health officials' emphasis on preventive medicine. This expanding market highlights the importance of water [...]

Protein aggregates in biological drugs have the potential to trigger an immune response in the patient, which, at the very least, can decrease the drug's effectiveness, and at worst could [...]

Pharmaceutical manufacturing processes continue to evolve, periodically embracing technological developments such as disposable components and regulatory initiatives such as process analytical technology (PAT). These changes have improved many operations, yet [...]

Patents on many popular medicines will soon expire, and makers of generic drugs threaten to reduce Big Pharma's profits by marketing low-cost versions of these therapies. Because the industry's pipelines [...]

FROM JAMA NEUROLOGY In patients with chronic traumatic encephalopathy (CTE), dementia likely results from neuropathologic changes associated with repetitive head impact (e.g., white-matter rarefaction and tau accumulation) and pathologic changes [...]

CHICAGO -- Dietary therapies can form a beneficial part of personalized treatment for gastroesophageal reflux disease (GERD), according to an overview presented at the Freston Conference, sponsored by the American [...]

CHICAGO -- Dietary therapies can form a beneficial part of personalized treatment for gastroesophageal reflux disease (GERD), according to an overview presented at the Freston Conference, sponsored by the American [...]

Live attenuated influenza vaccine in children and teens with asthma or recurrent wheezing does not increase risk of postvaccination lower respiratory events (LREs), according to an analysis published in Vaccine. [...]

REPORTING FROM AAD 2019 WASHINGTON -- The prescription of oral antibiotics after benign excisions, malignant excisions, and Mohs surgery has increased over the past decade, according to an analysis presented [...]

More than any other dosage form, injectable drugs require a manufacturing process that ensures sterility. Problems discovered at Genzyme's (Cambridge, MA) Allston Landing, Massachusetts, facility last fall illustrated how contamination [...]

EXPERT ANALYSIS FROM AAD 2019 WASHINGTON -- When repigmentation therapy fails, dermatologists may offer depigmentation therapy to patients with vitiligo, Seemal Desai, MD, said at the annual meeting of the [...]

REPORTING FROM AAD 19 WASHINGTON -- In addition to improving patient access, teledermatology can increase the efficiency of dermatology services, according to a retrospective study presented at the annual meeting [...]

The prescription of positive airway pressure is associated with reduced all-cause mortality, according to the results of a cohort study published in JAMA Otolaryngology-Head & Neck Surgery. The association becomes [...]

FROM THE JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY Adherence to a plant-based diet is inversely linked to the risk of incident heart failure, an analysis published online in the [...]

REPORTING FROM AES 2018 NEW ORLEANS -- Children with epilepsy need to be screened regularly for depression, based on results of a study presented at the annual meeting of the [...]

Among people of the same age, the degree of frailty influences the association between Alzheimer's disease pathology and Alzheimer's dementia, according to research published online ahead of print Jan. 17 [...]

Anyone keeping abreast of industry trends in the pharmaceutical market has noticed the enthusiasm that drug developers, investors, and even traditional pharmaceutical companies have for biological drugs. Motivated as much [...]

Pharmaceutical Technology and the Interphex 2006 Conference and Exhibition (Norwalk, CT, www.interphex.com) presented the first GenerationNext Awards for Emerging Leaders in Pharmaceutical Science and Technology on March 21, 2006. The [...]

"Patients who have AQP4-positive NMOSD, for exam• Satra/izumab, an anti-interleukin-6-receptor antagonist that pie, generally will not also have MOG antibodies, and vice received approval in August 2020, can be self-administered versa", said Dr. Wingerchuk. Among the Moreover, response to treatment for NMOSD appeared not to clinical differences is a higher percentage of patients with differ from patient to patient based on the presence or absence optic neuritis than myelitis for those with MOGAD. The complement inhibitor ecuThe question of autoantibody-based criteria lizuniab was the first treatment to receive FDA approval for Clinical and radiologic distinctions between AQP4-positive NMOSD patients who are AQP4 autoantibody-positive. The 2015 revised criteria facilitated recruitment oE patients Basis of 2015 criteria into clinical trials by liberalizing the diagnosis and including The 2015 diagnostic criteria reflected recent advances in the patients with only a single attack when a marker antibody is diagnosis of NMOSD. [Extracted from the article]