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1. Instruments and Strategies of the Social Support System in Rural Brescia During the Eighteenth Century

Author

GREGORINI G, MAFFI L, ROCHINI M, Gregorini, Giovanni, GREGORINI G (ORCID:0000-0003-0652-4852), GREGORINI G, MAFFI L, ROCHINI M, Gregorini, Giovanni, and GREGORINI G (ORCID:0000-0003-0652-4852)

Abstract

The social support system of Brescia represents, in many ways, an exemplary case. Indeed, it was driven by an original perspective of social reform that can be traced back to a substantial harmony among different measures that involved political power, the diocesan Church, and local communities. In the eighteenth century, it was the variegated structure of the charitable-assistance fabric of the parishes that allowed the Brescian territory to cope with the socio-economic problems connected to the progressive pauperization of the population. The commitment of the community acted as a cushion during critical junctures in recurring subsistence crises, helping to limit the spread of explosive convulsions of socio-political rebellion while at the same time laying the foundations for subsequent development. The active role of the communities and the overall reticular structure are thus highlighted as distinctive features of a system destined to last at least until the end of the eighteenth century, until the breakdown of the consolidated balance between emerging needs and demands for innovative reforms.

Published
2023

2. Formal and Informal Social Support Systems in Northern Italy: A Regional Assessment

Author

GREGORINI G, MAFFI L, ROCHINI M, Gregorini, Giovanni, Maffi, Luciano, Rochini, Marco, GREGORINI G (ORCID:0000-0003-0652-4852), MAFFI l (ORCID:0000-0003-0933-5758), GREGORINI G, MAFFI L, ROCHINI M, Gregorini, Giovanni, Maffi, Luciano, Rochini, Marco, GREGORINI G (ORCID:0000-0003-0652-4852), and MAFFI l (ORCID:0000-0003-0933-5758)

Abstract

The aim of this chapter is to highlight that the societies of the Old Regime presented a heterogeneous and pluralistic character. This stemmed from the presence of intermediate bodies between the central government and the single individual. The establishment of the local State, which began during the fifteenth century, did not eliminate this complexity, which persisted into the late 1700s. We examine the development of social support systems in the early modern period in the rural areas of the regional/city-states of northern Italy. This investigation achieves two main purposes: first, it allows researchers to understand the concrete role played by welfare and micro-credit in the political and socio-economic panorama of rural northern Italy; secondly, it analyses the extent to which the formation of a more or less structured support system influenced the establishment of local identity and the rooting of individuals. It is within this context that a complex and dynamic polyhedrality of formal and informal social support systems developed in rural areas. These systems characterized an extraordinary period of diversified strategies for providing social support to the needy.

Published
2023

3. Le virtù della carità. Patrimonio ecclesiastico, finanza comportamentale e sviluppo territoriale nell'Italia del XX secolo

Author

Gregorini, G, Semeraro, R, Taccolini, M, Gregorini, M, Semeraro, Riccardo, Gregorini, Giovanni, Semeraro, R (ORCID:0000-0003-4181-1064), Gregorini, G (ORCID:0000-0003-0652-4852), Gregorini, G, Semeraro, R, Taccolini, M, Gregorini, M, Semeraro, Riccardo, Gregorini, Giovanni, Semeraro, R (ORCID:0000-0003-4181-1064), and Gregorini, G (ORCID:0000-0003-0652-4852)

Abstract

La carità non solo è una virtù (teologale), la carità ha anche delle virtù, compresa quella di dialogare con lo sviluppo economico e sociale dei territori. Si tratta di un dialogo che coinvolge uomini e istituzioni, che fornisce servizi e movimenta risorse finanziarie, che alimenta dibattiti culturali di ampio respiro su aspetti riguardanti la poliedrica realtà dello scambio asimmetrico, richiamando concetti come quelli di dono, di condivisione, di gratuità .

Published
2022

4. Introduzione

Author

Gregorini, G, Semeraro, R, Taccolini, M, Gregorini, Giovanni, Semeraro, Riccardo, Taccolini, Mario, Gregorini, G (ORCID:0000-0003-0652-4852), Semeraro, R (ORCID:0000-0003-4181-1064), Taccolini, M (ORCID:0000-0002-5687-2778), Gregorini, G, Semeraro, R, Taccolini, M, Gregorini, Giovanni, Semeraro, Riccardo, Taccolini, Mario, Gregorini, G (ORCID:0000-0003-0652-4852), Semeraro, R (ORCID:0000-0003-4181-1064), and Taccolini, M (ORCID:0000-0002-5687-2778)

Abstract

Negli ultimi anni si è assistito a crescenti difficoltà per le prospettive evolutive della ricerca dedicata ai temi della povertà e dell’innovazione istituzionale realizzata per affrontarla. Tuttavia, questo indirizzo di studi continua a offrire interessanti spunti di indagine e preziose indicazioni per le politiche di contrasto alle vecchie e nuove forme di marginalità, soprattutto in termini di coinvolgimento e valorizzazione delle comunità, dei corpi intermedi, delle intuizioni carismatiche che, nel corso del tempo, hanno dato respiro alla prospettiva sussidiaria di costruzione di una società più equa. Proprio grazie ai suddetti spunti di indagine, e alle correlate indicazioni per le politiche di intervento, la storia può aiutare a costruire la pace sociale, a perseguire la giustizia compensando le disuguaglianze, a rafforzare il contesto istituzionale odierno, nazionale e internazionale. L’obiettivo di questo volume è discutere il tema della povertà nella storia, analizzando le prospettive di ricerca più recenti e innovative perseguite a livello europeo, delineando il profilo di un nuovo lessico interdisciplinare storicamente fondato e individuando nuove fonti per le indagini storiche.

Published
2022

5. Social Support Systems in Rural Italy. The Modern Age Regional States of the Northern Peninsula

Author

GREGORINI G (ORCID:0000-0003-0652-4852), MAFFI l (ORCID:0000-0003-0933-5758), ROCHINI M, Gregorini, Giovanni, Maffi, Luciano, Rochini, Marco, GREGORINI G (ORCID:0000-0003-0652-4852), MAFFI l (ORCID:0000-0003-0933-5758), ROCHINI M, Gregorini, Giovanni, Maffi, Luciano, and Rochini, Marco

Abstract

This book examines the development of social support systems in the Modern age in the rural areas of the city-states of Northern Italy. This investigation achieves two main purposes: first, it allows researchers to understand the role occupied concretely by welfare and micro-credit activities in the political and socio-economic panorama of rural Northern Italy; secondly, it verifies to what extent the formation of a more or less structured support system influenced the establishment of local identity and the rooting of individuals. The book brings together perspectives from different fields of research ranging from economic and political history to the study of the history of ecclesiastical institutions, as well as integrating recent research on the anthropological value of welfare actions and the use of multiple historical sources. It considers how the retreat of the welfare activity of the State, associated with a depopulation of the rural areas of the peninsula and a steady increase of poverty into social fringes that were previously not affected by economic problems, pushes us to investigate more carefully the dynamics that in the Ancien Régime gave shape to the support activities against indigence and poverty. This book will be of interest to academics and students working in economic history and social history.

Published
2023

6. Nota dei curatori

Author

Gregorini, G, Semeraro, R, Gregorini, Giovanni, Semeraro, Riccardo, Gregorini, G (ORCID:0000-0003-0652-4852), Semeraro, R (ORCID:0000-0003-4181-1064), Gregorini, G, Semeraro, R, Gregorini, Giovanni, Semeraro, Riccardo, Gregorini, G (ORCID:0000-0003-0652-4852), and Semeraro, R (ORCID:0000-0003-4181-1064)

Abstract

Turismo 4.0 approfondisce, in tre macro-sezioni, le implicazioni economiche, sociali, linguistiche e imprenditoriali del turismo territoriale. La prima parte raccoglie diversi saggi aventi per oggetto la storia del turismo in età contemporanea. Nella seconda e nella terza, che conferiscono al volume un taglio multidisciplinare, trovano spazio le ricerche di linguisti, sociologi, esperti del marketing e delle scienze aziendali. Con queste pagine si intende dare ulteriore e fattivo sviluppo a iniziative di studio, ricerca e formazione che la sede di Brescia dell’Università Cattolica, anche per mezzo della Facoltà di Scienze linguistiche e letterature straniere e del Dipartimento di Scienze storiche e filologiche, ha promosso e sta promuovendo con riferimento al turismo territoriale caratterizzato da una fortissima vocazione internazionale. Allo stesso modo, il volume si propone di alimentare, con contenuti innovativi, il rapporto, anche in termini di Terza missione, con i soggetti istituzionali del territorio coinvolti da tempo attraverso il servizio Cattolica per il turismo.

Published
2021

7. Il vanto di Napoli. Origini e primi sviluppi della triplice cassa diocesana tra Ottocento e Novecento

Author

Gregorini, G., Romani, M., Semeraro, Riccardo, Gregorini, Giovanni, Semeraro R. (ORCID:0000-0003-4181-1064), Gregorini G. (ORCID:0000-0003-0652-4852), Gregorini, G., Romani, M., Semeraro, Riccardo, Gregorini, Giovanni, Semeraro R. (ORCID:0000-0003-4181-1064), and Gregorini G. (ORCID:0000-0003-0652-4852)

Abstract

Il rapporto tra Chiesa ed economia rappresenta un tema di particolare interesse per la ricerca storica sia in ambito nazionale che internazionale. Ad essere oggetto, da tempo, di numerosi studi sono precipuamente le questioni finanziarie nelle loro molteplici declinazioni, soprattutto con attinenza al ruolo della Santa Sede in età contemporanea. Nonostante ciò, è pressoché assente una riflessione sugli aspetti finanziari delle diocesi italiane. Il presente saggio intende offrire un contributo alla ricerca scientifica avente per oggetto le casse diocesane ricostruendo e analizzando un nuovo caso studio, ancora non preso in esame dalla storiografia: il caso della cassa o, sarebbe più corretto dire delle casse di Napoli.

Published
2021

8. Il Welfare Responsabile tra centralità della persona, logica di rete, governance orizzontale

Author

Gregorini G., Semeraro R., Taccolini M., Pavesi, N., Cesareo, V., Pavesi N. (ORCID:0000-0002-1996-6919), Cesareo V. (ORCID:0000-0002-6427-2246), Gregorini G., Semeraro R., Taccolini M., Pavesi, N., Cesareo, V., Pavesi N. (ORCID:0000-0002-1996-6919), and Cesareo V. (ORCID:0000-0002-6427-2246)

Abstract

Il contributo si interroga su come la proposta del welfare responsabile sia in grado di rispondere in modo innovativo alle vecchie e nuove povertà che caratterizzano ancora la società italiana. Attraverso l'attivazione capacitante, la reticolazione dei soggetti in una logica di et-et, la costruzione di spazi sociali di prossimità si rendono le comunità competenti sulla propria vita, in grado di comprendere i bisogni e di attivare risposte rapide, efficienti ed efficaci.

Published
2022

9. Nuove fonti per la storia del movimento degli oratori e della loro vocazione sociale nel corso del Novecento

Author

Gregorini, G, Semeraro R, Taccolini M, Alfieri, Paolo, Alfieri,Paolo (ORCID:0000-0003-2836-7421), Gregorini, G, Semeraro R, Taccolini M, Alfieri, Paolo, and Alfieri,Paolo (ORCID:0000-0003-2836-7421)

Abstract

Il saggio si sofferma sulla funzione di supporto sociale svolta dagli oratori italiani nel XX secolo, cominciando col ricostruirne le radici storiche nel quadro di una vicenda in cui in cui la carità è stata declinata soprattutto in un’opera pastorale ed educativa per e con le giovani generazioni. La storia degli oratori italiani – e soprattutto quella novecentesca – è, infatti, la storia dell’impegno messo in atto dalla Chiesa sul terreno dell’educazione popolare non solo per raggiungere ed accompagnare nella loro crescita le masse giovanili, ma anche per coinvolgerle in una proposta formativa orientata a favorire loro maturazione ad un tempo spirituale, umana e civile. Il contributo presenta poi alcune direttrici di ricerca per approfondire lo studio del passato degli oratori attraverso un rinnovato sguardo interpretativo, capace di fare tesoro anche delle più recenti suggestioni della ricerca storico-educativa e del suo invito a rileggere fonti già utilizzate o a ricorrere a nuovo materiale documentario. Si fa, infine, riferimento alla questione della memoria educativa dell’oratorio, lumeggiando soprattutto il processo di ricostruzione sociale del passato oratoriano alimentato da alcuni recenti prodotti dell’industria culturale.

Published
2022

10. I volti della povertà. Temi, parole, fonti per la storia dei sistemi di supporto sociale tra modernità e globalizzazione

Author

Gregorini, G (ORCID:0000-0003-0652-4852), Semeraro, R (ORCID:0000-0003-4181-1064), Taccolini, M (ORCID:0000-0002-5687-2778), Gregorini, Giovanni, Semeraro, Riccardo, Taccolini, Mario, Gregorini, G (ORCID:0000-0003-0652-4852), Semeraro, R (ORCID:0000-0003-4181-1064), Taccolini, M (ORCID:0000-0002-5687-2778), Gregorini, Giovanni, Semeraro, Riccardo, and Taccolini, Mario

Abstract

Negli ultimi anni si è assistito a crescenti difficoltà per le prospettive evolutive della ricerca dedicata ai temi della povertà e dell’innovazione istituzionale realizzata per affrontarla. Tuttavia, questo indirizzo di studi continua a offrire interessanti spunti di indagine e preziose indicazioni per le politiche di contrasto alle vecchie e nuove forme di marginalità, soprattutto in termini di coinvolgimento e valorizzazione delle comunità, dei corpi intermedi, delle intuizioni carismatiche che, nel corso del tempo, hanno dato respiro alla prospettiva sussidiaria di costruzione di una società più equa. Proprio grazie ai suddetti spunti di indagine, e alle correlate indicazioni per le politiche di intervento, la storia può aiutare a costruire la pace sociale, a perseguire la giustizia compensando le disuguaglianze, a rafforzare il contesto istituzionale odierno, nazionale e internazionale. L’obiettivo di questo volume è discutere il tema della povertà nella storia, analizzando le prospettive di ricerca più recenti e innovative perseguite a livello europeo, delineando il profilo di un nuovo lessico interdisciplinare storicamente fondato e individuando nuove fonti per le indagini storiche.

Published
2022

11. Assistere, curare, finanziare: la sanità cattolica in Lombardia tra Ottocento e Novecento

Author

Vilar-Rodríguez, M, Pons-Pons, J, Semeraro, Riccardo, Gregorini, Giovanni, Semeraro, R (ORCID:0000-0003-4181-1064), Gregorini, G (ORCID:0000-0003-0652-4852), Vilar-Rodríguez, M, Pons-Pons, J, Semeraro, Riccardo, Gregorini, Giovanni, Semeraro, R (ORCID:0000-0003-4181-1064), and Gregorini, G (ORCID:0000-0003-0652-4852)

Abstract

Alle origini dei sistemi di welfare locale in Italia vi sono enti religiosi che hanno operato in una prospettiva sussidiaria rispetto al ruolo svolto dallo Stato in età contemporanea. Nonostante l’abbondanza di studi sul ruolo svolto dagli istituti religiosi cattolici nel campo dell’educazione e della cura dei poveri, pochi studiosi hanno indagato le loro opere nel sistema sanitario. Questo argomento ha assunto ancor più importanza alla luce delle differenze e delle inadeguatezze territoriali rese evidenti dal Covid-19. Concentrandosi su un caso di studio significativo, questo articolo analizza come gli ordini e le congregazioni religiose si siano sviluppati e siano intervenuti nel quadro del sistema ospedaliero italiano tra Ottocento e Novecento.

Published
2022

12. Risk of acute arterial and venous thromboembolic events in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

Author

Bettiol, A., Sinico, R. A., Schiavon, F., Monti, S., Bozzolo, E. P., Franceschini, F., Govoni, M., Lunardi, C., Guida, G., Lopalco, G., Paolazzi, G., Vacca, A., Gregorini, G., Leccese, P., Piga, M., Conti, F., Fraticelli, P., Quartuccio, L., Alberici, F., Salvarani, C., Bettio, S., Negrini, S., Selmi, C., Sciascia, S., Moroni, G., Colla, L., Manno, C., Urban, M. L., Vannacci, A., Pozzi, M. R., Fabbrini, P., Polti, S., Felicetti, M., Marchi, M. R., Padoan, R., Delvino, P., Caporali, R., Montecucco, C., Dagna, L., Cariddi, A., Toniati, P., Tamanini, S., Furini, F., Bortoluzzi, A., Tinazzi, E., Delfino, L., Badiu, I., Rolla, G., Venerito, V., Iannone, F., Berti, A., Bortolotti, R., Racanelli, V., Jeannin, G., Padula, A., Cauli, A., Priori, R., Gabrielli, A., Bond, M., Tedesco, M., Pazzola, G., Tomietto, P., Pellecchio, M., Marvisi, C., Maritati, F., Palmisano, A., Dejaco, C., Willeit, J., Kiechl, S., Olivotto, I., Willeit, P., Prisco, D., Vaglio, A., Emmi, G., Bargagli, E., Becatti, M., Beccalli, M., Bello, F., Bozzao, F., Canti, V., Cassia, M. A., Cassone, G., Catanoso, M., Chieco-Bianchi, F., Clari, R., Coladonato, L., De Santis, M., Di Scala, G., Fagni, F., Fenaroli, P., Fiorillo, C., Floris, A., Fornaro, M., Galli, E., Generali, E., Giliberti, M., Lascaro, N., Leccese, I., Mattioli, I., Olivieri, B., Osti, N., Peyronel, F., Radin, M., Righetti, G., Salvati, S., Silvestri, E., Susca, N., Tamburini, C., Taurisano, G., Trezzi, B., Trivioli, G., Bettiol, A, Sinico, R, Schiavon, F, Monti, S, Bozzolo, E, Franceschini, F, Govoni, M, Lunardi, C, Guida, G, Lopalco, G, Paolazzi, G, Vacca, A, Gregorini, G, Leccese, P, Piga, M, Conti, F, Fraticelli, P, Quartuccio, L, Alberici, F, Salvarani, C, Bettio, S, Negrini, S, Selmi, C, Sciascia, S, Moroni, G, Colla, L, Manno, C, Urban, M, Vannacci, A, Pozzi, M, Fabbrini, P, Polti, S, Felicetti, M, Marchi, M, Padoan, R, Delvino, P, Caporali, R, Montecucco, C, Dagna, L, Cariddi, A, Toniati, P, Tamanini, S, Furini, F, Bortoluzzi, A, Tinazzi, E, Delfino, L, Badiu, I, Rolla, G, Venerito, V, Iannone, F, Berti, A, Bortolotti, R, Racanelli, V, Jeannin, G, Padula, A, Cauli, A, Priori, R, Gabrielli, A, Bond, M, Tedesco, M, Pazzola, G, Tomietto, P, Pellecchio, M, Marvisi, C, Maritati, F, Palmisano, A, Dejaco, C, Willeit, J, Kiechl, S, Olivotto, I, Willeit, P, Prisco, D, Vaglio, A, and Emmi, G

Subjects
Pulmonary and Respiratory Medicine, Burden of disease, Humans, Churg-Strauss Syndrome, Granulomatosis with Polyangiitis, Venous Thromboembolism, Venous Thrombosis, Churg-strauss syndrome, Criminology, NO, 03 medical and health sciences, 0302 clinical medicine, Medicine, 030212 general & internal medicine, Vascular inflammation, business.industry, Conflict of interest, Cytoplasmic antibody, medicine.disease, 030228 respiratory system, Wegener granulomatosis, arterial and venous thromboembolic events, Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss syndrome), Organ involvement, business, Production team
Abstract

Eosinophilic Granulomatosis with Polyangiitis (EGPA, Churg-Strauss syndrome) is a rare anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) characterised by respiratory manifestations and systemic organ involvement [1]. Particularly, cardiac manifestations occur in 40–60% of patients, representing the leading cause of mortality [2]. Recent reports suggest that venous thromboembolic events might also represent a consistent burden of disease [3, 4], as already known for the other AAVs [5–7], possibly due to eosinophil-mediated vascular inflammation [5]. Nevertheless, the occurrence of arterial and venous thrombotic events (AVTE) has never been systematically explored in EGPA. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article. Conflict of interest: Alessandra Bettiol Conflict of interest: Renato Alberto Sinico Conflict of interest: Franco Schiavon Conflict of interest: Sara Monti Conflict of interest: Enrica Paola Bozzolo Conflict of interest: Franco Franceschini Conflict of interest: Marcello Govoni Conflict of interest: Claudio Lunardi Conflict of interest: Giuseppe Guida Conflict of interest: Giuseppe Lopalco Conflict of interest: Giuseppe Paolazzi Conflict of interest: Angelo Vacca Conflict of interest: Gina Gregorini Conflict of interest: Pietro Leccese Conflict of interest: Matteo Piga Conflict of interest: Fabrizio Conti Conflict of interest: Paolo Fraticelli Conflict of interest: Luca Quartuccio Conflict of interest: Federico Alberici Conflict of interest: Carlo Salvarani Conflict of interest: Silvano Bettio Conflict of interest: Simone Negrini Conflict of interest: Carlo Selmi Conflict of interest: Savino Sciascia Conflict of interest: Gabriella Moroni Conflict of interest: Loredana Colla Conflict of interest: Carlo Manno Conflict of interest: Maria Letizia Urban Conflict of interest: Alfredo Vannacci Conflict of interest: Maria Rosa Pozzi Conflict of interest: Paolo Fabbrini Conflict of interest: Stefano Polti Conflict of interest: Mara Felicetti Conflict of interest: Maria Rita Marchi Conflict of interest: Roberto Padoan Conflict of interest: Paolo Delvino Conflict of interest: Roberto Caporali Conflict of interest: Carlomaurizio Montecucco Conflict of interest: Lorenzo Dagna Conflict of interest: Adriana Cariddi Conflict of interest: Paola Toniati Conflict of interest: Dr. Tamanini reports other from Glaxo Smith Kline, outside the submitted work. Conflict of interest: Federica Furini Conflict of interest: Alessandra Bortoluzzi Conflict of interest: Elisa Tinazzi Conflict of interest: Lorenzo Delfino Conflict of interest: Iuliana Badiu Conflict of interest: Giovanni Rolla Conflict of interest: Vincenzo Venerito Conflict of interest: Florenzo Iannone Conflict of interest: Alvise Berti Conflict of interest: Roberto Bortolotti Conflict of interest: Vito Racanelli Conflict of interest: Guido Jeannin Conflict of interest: Angela Padula Conflict of interest: Alberto Cauli Conflict of interest: Roberta Priori Conflict of interest: Armando Gabrielli Conflict of interest: Milena Bond Conflict of interest: Martina Tedesco Conflict of interest: Giulia Pazzola Conflict of interest: Paola Tomietto Conflict of interest: Marco Pellecchio Conflict of interest: Chiara Marvisi Conflict of interest: Federica Maritati Conflict of interest: Alessandra Palmisano Conflict of interest: Christian Dejaco Conflict of interest: Johann Willeit Conflict of interest: Stefan Kiechl Conflict of interest: Iacopo Olivotto Conflict of interest: Peter Willeit Conflict of interest: Domenico Prisco Conflict of interest: Augusto Vaglio Conflict of interest: Giacomo Emmi

Published
2020

13. Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Author

Lyons, P. A., Peters, J. E., Alberici, F., Liley, J., Coulson, R. M. R., Astle, W., Baldini, C., Bonatti, F., Cid, María Cinta, Elding, H., Emmi, G., Epplen, J., Guillevin, L., Jayne, D. R. W., Jiang, T., Gunnarsson, I., Lamprecht, P., Leslie, S., Little, M. A., Martorana, D., Moosig, F., Neumann, T., Ohlsson, S., Quickert, S., Ramirez, G. A., Rewerska, B., Schett, George, Sinico, R. A., Szczeklik, W., Tesar, Vladimir, Vukcevic, D., Akil, M., Barratt, J., Basu, N., Butterworth, A. S., Bruce, I., Clarkson, M., Conlon, N., DasGupta, B., Doulton, T. W. R., Espígol-Frigolé, Georgina, Flossmann, O., Gabrielli, A., Gasior, J., Gregorini, G., Guida, G., Hernández Rodríguez, José, Hruskova, Z., Hudson, A., Knight, A., Lanyon, P., Luqmani, R., Magliano, M., Manfredi, A. A., Marguerie, C., Maritati, F., Marvisi, C., McHugh, N. J., Molloy, E., Motyer, A., Mukhtyar, C., Padyukov, Leonid, Pesci, Alberto, Prieto-Gonzalez, S., Ramentol-Sintas, Marc, Reis, P., Roccatello, D., Rovere-Querini, P., Salvarani, C., Santarsia, F., Solans, Roser, Soranzo, N., Taylor, J., Wessels, J., Zwerina, J., Terrier, B., Watts, R. A., Vaglio, A., Holle, J. U., Wallace, C., Smith, K. G. C., Universitat Autònoma de Barcelona, Lyons, P. A., Peters, J. E., Alberici, F., Liley, J., Coulson, R. M. R., Astle, W., Baldini, C., Bonatti, F., Cid, M. C., Elding, H., Emmi, G., Epplen, J., Guillevin, L., Jayne, D. R. W., Jiang, T., Gunnarsson, I., Lamprecht, P., Leslie, S., Little, M. A., Martorana, D., Moosig, F., Neumann, T., Ohlsson, S., Quickert, S., Ramirez, G. A., Rewerska, B., Schett, G., Sinico, R. A., Szczeklik, W., Tesar, V., Vukcevic, D., Akil, M., Barratt, J., Basu, N., Butterworth, A. S., Bruce, I., Clarkson, M., Conlon, N., Dasgupta, B., Doulton, T. W. R., Espigol-Frigole, G., Flossmann, O., Gabrielli, A., Gasior, J., Gregorini, G., Guida, G., Hernandez-Rodriguez, J., Hruskova, Z., Hudson, A., Knight, A., Lanyon, P., Luqmani, R., Magliano, M., Manfredi, A. A., Marguerie, C., Maritati, F., Marvisi, C., Mchugh, N. J., Molloy, E., Motyer, A., Mukhtyar, C., Padyukov, L., Pesci, A., Prieto-Gonzalez, S., Ramentol-Sintas, M., Reis, P., Roccatello, D., Rovere-Querini, P., Salvarani, C., Santarsia, F., Solans-Laque, R., Soranzo, N., Taylor, J., Wessels, J., Zwerina, J., Terrier, B., Watts, R. A., Vaglio, A., Holle, J. U., Wallace, C., Smith, K. G. C., Lyons, P, Peters, J, Alberici, F, Liley, J, Coulson, R, Astle, W, Baldini, C, Bonatti, F, Cid, M, Elding, H, Emmi, G, Epplen, J, Guillevin, L, Jayne, D, Jiang, T, Gunnarsson, I, Lamprecht, P, Leslie, S, Little, M, Martorana, D, Moosig, F, Neumann, T, Ohlsson, S, Quickert, S, Ramierez, G, Rewerska, B, Schett, G, Sinico, R, Szczeklik, W, Tesar, V, Vukcevic, D, Akil, M, Barratt, J, Basu, N, Butterworth, A, Bruce, I, Clarkson, M, Conlon, N, Dasgupta, B, Doulton, T, Espigol-Frigole, G, Flossmann, O, Gabrielli, A, Gasior, J, Gregorini, G, Guida, G, Hernandez-Rodriguez, J, Hruskova, Z, Hudson, A, Knight, A, Lanyon, P, Luqmani, R, Magliano, M, Manfredi, A, Marguerie, C, Maritati, F, Marvisi, C, Mchugh, N, Molloy, E, Motyer, A, Mukhtyar, C, Padyukov, L, Pesci, A, Prieto-Gonzalez, S, Ramentol-Sintas, M, Reis, P, Roccatello, D, Rovere-Querini, P, Salvarani, C, Santarsia, F, Solans-Laque, R, Soranzo, N, Taylor, J, Wessels, J, Zwerina, J, Terrier, B, Watts, R, Vaglio, A, Holle, J, Wallace, C, Smith, K, and United Kingdom Research and Innovation

Subjects
0301 basic medicine, Candidate gene, Antineutrophil Cytoplasmic, General Physics and Astronomy, Genome-wide association study, Autoimmunity, Genome-wide association studies, 0302 clinical medicine, Rheumatic diseases, immune system diseases, Eosinophilic, Eosinophilia, lcsh:Science, education.field_of_study, Multidisciplinary, Genome-wide association, eosinophilic granulomatosis with polyangiitis, ANCA status, 3. Good health, medicine.symptom, Vasculitis, Granulomatosis with polyangiitis, Antibodies, Antineutrophil Cytoplasmic, Eosinophils, Genetic Association Studies, Granulomatosis with Polyangiitis, Humans, Mendelian Randomization Analysis, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, European Vasculitis Genetics Consortium, Science, Population, General Biochemistry, Genetics and Molecular Biology, Article, Antibodies, 03 medical and health sciences, medicine, Immunogenetics, education, Rheumatology and Autoimmunity, Anti-neutrophil cytoplasmic antibody, 030203 arthritis & rheumatology, Reumatologi och inflammation, business.industry, General Chemistry, medicine.disease, respiratory tract diseases, 030104 developmental biology, Immunology, EGPA, HLA, ANCA, genetics, lcsh:Q, business
Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association study in 676 EGPA cases and 6809 controls, that identifies 4 EGPA-associated loci through conventional case-control analysis, and 4 additional associations through a conditional false discovery rate approach. Many variants are also associated with asthma and six are associated with eosinophil count in the general population. Through Mendelian randomisation, we show that a primary tendency to eosinophilia contributes to EGPA susceptibility. Stratification by ANCA reveals that EGPA comprises two genetically and clinically distinct syndromes. MPO+ ANCA EGPA is an eosinophilic autoimmune disease sharing certain clinical features and an HLA-DQ association with MPO+ ANCA-associated vasculitis, while ANCA-negative EGPA may instead have a mucosal/barrier dysfunction origin. Four candidate genes are targets of therapies in development, supporting their exploration in EGPA., Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disorder characterised by asthma, eosinophilia and vasculitis. Here, the authors describe a genome-wide association study of EGPA that reveals clinical and genetic differences between subgroups stratified by autoantibody status (ANCA).

Published
2019

14. Margini e marginalità

Author

Bianchetti A., Rozzini R., Simeone D., Del Bono E., Tremolada A, Semeraro R., Gregorini G., Donato F., Magoni M., Triboldi A., Sileo C., Latronico N., Giannini A., Sergio Cattaneo, Frank Rasulo, Donati E., Tosi L., Di Stefano O., Pace S., Lucchi E., Palazzani L., Canobbio G., Pasini G., Rivoltella P. C., Amadini M., Buizza C., Mesa D., Angelini U., Bazoli F., Archetti M., Domenico S., Mesa, Diego, Buizza, Chiara, Diego Mesa (ORCID:0000-0003-0491-4988), Bianchetti A., Rozzini R., Simeone D., Del Bono E., Tremolada A, Semeraro R., Gregorini G., Donato F., Magoni M., Triboldi A., Sileo C., Latronico N., Giannini A., Sergio Cattaneo, Frank Rasulo, Donati E., Tosi L., Di Stefano O., Pace S., Lucchi E., Palazzani L., Canobbio G., Pasini G., Rivoltella P. C., Amadini M., Buizza C., Mesa D., Angelini U., Bazoli F., Archetti M., Domenico S., Mesa, Diego, Buizza, Chiara, and Diego Mesa (ORCID:0000-0003-0491-4988)

Abstract

Il contributo propone un'analisi dei cambiamenti delle forme di povertà e marginalità sociale indotti dall'emergenza Covid-19 nel contesto della città di Brescia

Published
2021

15. Turismo 4.0. Storia, digitalizzazione, territorio

Author

Gregorini, G (ORCID:0000-0003-0652-4852), Semeraro, R (ORCID:0000-0003-4181-1064), Gregorini, Giovanni, Semeraro, Riccardo, Gregorini, G (ORCID:0000-0003-0652-4852), Semeraro, R (ORCID:0000-0003-4181-1064), Gregorini, Giovanni, and Semeraro, Riccardo

Abstract

Turismo 4.0 approfondisce, in tre macro-sezioni, le implicazioni economiche, sociali, linguistiche e imprenditoriali del turismo territoriale. La prima parte raccoglie diversi saggi aventi per oggetto la storia del turismo in età contemporanea. Nella seconda e nella terza, che conferiscono al volume un taglio multidisciplinare, trovano spazio le ricerche di linguisti, sociologi, esperti del marketing e delle scienze aziendali. Con queste pagine si intende dare ulteriore e fattivo sviluppo a iniziative di studio, ricerca e formazione che la sede di Brescia dell’Università Cattolica, anche per mezzo della Facoltà di Scienze linguistiche e letterature straniere e del Dipartimento di Scienze storiche e filologiche, ha promosso e sta promuovendo con riferimento al turismo territoriale caratterizzato da una fortissima vocazione internazionale. Allo stesso modo, il volume si propone di alimentare, con contenuti innovativi, il rapporto, anche in termini di Terza missione, con i soggetti istituzionali del territorio coinvolti da tempo attraverso il servizio Cattolica per il turismo.

Published
2021

16. Biblioteca di Storia delle Scienze 'Carlo Viganò'

Author

Anni, R, Canova, A, Contini, R, Ferrari, A, Goffi, P, Gregorini, G, Lombardi, S, Mor, L, Pasini, MP, Semeraro, R, Spera, M, Taccolini, M, Toloni, G, Canova, Andrea, Goffi, Pierangelo, Spera, Mauro, Mauro Spera (ORCID:0000-0001-9041-364X), Anni, R, Canova, A, Contini, R, Ferrari, A, Goffi, P, Gregorini, G, Lombardi, S, Mor, L, Pasini, MP, Semeraro, R, Spera, M, Taccolini, M, Toloni, G, Canova, Andrea, Goffi, Pierangelo, Spera, Mauro, and Mauro Spera (ORCID:0000-0001-9041-364X)

Abstract

Assente

Published
2021

17. Risk of acute arterial and venous thromboembolic events in Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss syndrome)

Author

Bettiol, A, Sinico, R, Schiavon, F, Monti, S, Bozzolo, E, Franceschini, F, Govoni, M, Lunardi, C, Guida, G, Lopalco, G, Paolazzi, G, Vacca, A, Gregorini, G, Leccese, P, Piga, M, Conti, F, Fraticelli, P, Quartuccio, L, Alberici, F, Salvarani, C, Bettio, S, Negrini, S, Selmi, C, Sciascia, S, Moroni, G, Colla, L, Manno, C, Urban, M, Vannacci, A, Pozzi, M, Fabbrini, P, Polti, S, Felicetti, M, Marchi, M, Padoan, R, Delvino, P, Caporali, R, Montecucco, C, Dagna, L, Cariddi, A, Toniati, P, Tamanini, S, Furini, F, Bortoluzzi, A, Tinazzi, E, Delfino, L, Badiu, I, Rolla, G, Venerito, V, Iannone, F, Berti, A, Bortolotti, R, Racanelli, V, Jeannin, G, Padula, A, Cauli, A, Priori, R, Gabrielli, A, Bond, M, Tedesco, M, Pazzola, G, Tomietto, P, Pellecchio, M, Marvisi, C, Maritati, F, Palmisano, A, Dejaco, C, Willeit, J, Kiechl, S, Olivotto, I, Willeit, P, Prisco, D, Vaglio, A, Emmi, G, Bettiol, Alessandra, Sinico, Renato Alberto, Schiavon, Franco, Monti, Sara, Bozzolo, Enrica Paola, Franceschini, Franco, Govoni, Marcello, Lunardi, Claudio, Guida, Giuseppe, Lopalco, Giuseppe, Paolazzi, Giuseppe, Vacca, Angelo, Gregorini, Gina, Leccese, Pietro, Piga, Matteo, Conti, Fabrizio, Fraticelli, Paolo, Quartuccio, Luca, Alberici, Federico, Salvarani, Carlo, Bettio, Silvano, Negrini, Simone, Selmi, Carlo, Sciascia, Savino, Moroni, Gabriella, Colla, Loredana, Manno, Carlo, Urban, Maria Letizia, Vannacci, Alfredo, Pozzi, Maria Rosa, Fabbrini, Paolo, Polti, Stefano, Felicetti, Mara, Marchi, Maria Rita, Padoan, Roberto, Delvino, Paolo, Caporali, Roberto, Montecucco, Carlomaurizio, Dagna, Lorenzo, Cariddi, Adriana, Toniati, Paola, Tamanini, Silvia, Furini, Federica, Bortoluzzi, Alessandra, Tinazzi, Elisa, Delfino, Lorenzo, Badiu, Iuliana, Rolla, Giovanni, Venerito, Vincenzo, Iannone, Florenzo, Berti, Alvise, Bortolotti, Roberto, Racanelli, Vito, Jeannin, Guido, Padula, Angela, Cauli, Alberto, Priori, Roberta, Gabrielli, Armando, Bond, Milena, Tedesco, Martina, Pazzola, Giulia, Tomietto, Paola, Pellecchio, Marco, Marvisi, Chiara, Maritati, Federica, Palmisano, Alessandra, Dejaco, Christian, Willeit, Johann, Kiechl, Stefan, Olivotto, Iacopo, Willeit, Peter, Prisco, Domenico, Vaglio, Augusto, Emmi, Giacomo, Bettiol, A, Sinico, R, Schiavon, F, Monti, S, Bozzolo, E, Franceschini, F, Govoni, M, Lunardi, C, Guida, G, Lopalco, G, Paolazzi, G, Vacca, A, Gregorini, G, Leccese, P, Piga, M, Conti, F, Fraticelli, P, Quartuccio, L, Alberici, F, Salvarani, C, Bettio, S, Negrini, S, Selmi, C, Sciascia, S, Moroni, G, Colla, L, Manno, C, Urban, M, Vannacci, A, Pozzi, M, Fabbrini, P, Polti, S, Felicetti, M, Marchi, M, Padoan, R, Delvino, P, Caporali, R, Montecucco, C, Dagna, L, Cariddi, A, Toniati, P, Tamanini, S, Furini, F, Bortoluzzi, A, Tinazzi, E, Delfino, L, Badiu, I, Rolla, G, Venerito, V, Iannone, F, Berti, A, Bortolotti, R, Racanelli, V, Jeannin, G, Padula, A, Cauli, A, Priori, R, Gabrielli, A, Bond, M, Tedesco, M, Pazzola, G, Tomietto, P, Pellecchio, M, Marvisi, C, Maritati, F, Palmisano, A, Dejaco, C, Willeit, J, Kiechl, S, Olivotto, I, Willeit, P, Prisco, D, Vaglio, A, Emmi, G, Bettiol, Alessandra, Sinico, Renato Alberto, Schiavon, Franco, Monti, Sara, Bozzolo, Enrica Paola, Franceschini, Franco, Govoni, Marcello, Lunardi, Claudio, Guida, Giuseppe, Lopalco, Giuseppe, Paolazzi, Giuseppe, Vacca, Angelo, Gregorini, Gina, Leccese, Pietro, Piga, Matteo, Conti, Fabrizio, Fraticelli, Paolo, Quartuccio, Luca, Alberici, Federico, Salvarani, Carlo, Bettio, Silvano, Negrini, Simone, Selmi, Carlo, Sciascia, Savino, Moroni, Gabriella, Colla, Loredana, Manno, Carlo, Urban, Maria Letizia, Vannacci, Alfredo, Pozzi, Maria Rosa, Fabbrini, Paolo, Polti, Stefano, Felicetti, Mara, Marchi, Maria Rita, Padoan, Roberto, Delvino, Paolo, Caporali, Roberto, Montecucco, Carlomaurizio, Dagna, Lorenzo, Cariddi, Adriana, Toniati, Paola, Tamanini, Silvia, Furini, Federica, Bortoluzzi, Alessandra, Tinazzi, Elisa, Delfino, Lorenzo, Badiu, Iuliana, Rolla, Giovanni, Venerito, Vincenzo, Iannone, Florenzo, Berti, Alvise, Bortolotti, Roberto, Racanelli, Vito, Jeannin, Guido, Padula, Angela, Cauli, Alberto, Priori, Roberta, Gabrielli, Armando, Bond, Milena, Tedesco, Martina, Pazzola, Giulia, Tomietto, Paola, Pellecchio, Marco, Marvisi, Chiara, Maritati, Federica, Palmisano, Alessandra, Dejaco, Christian, Willeit, Johann, Kiechl, Stefan, Olivotto, Iacopo, Willeit, Peter, Prisco, Domenico, Vaglio, Augusto, and Emmi, Giacomo

Published
2021

18. Slowly progressive anti-neutrophil cytoplasmic antibody-associated renal vasculitis: clinico-pathological characterization and outcome

Author

Trivioli, G, Gopaluni, S, Urban, M, Gianfreda, D, Cassia, M, Vercelloni, P, Calatroni, M, Bettiol, A, Esposito, P, Murtas, C, Alberici, F, Maritati, F, Manenti, L, Palmisano, A, Emmi, G, Romagnani, P, Moroni, G, Gregorini, G, Sinico, R, Jayne, D, Vaglio, A, Trivioli, Giorgio, Gopaluni, Seerapani, Urban, Maria L, Gianfreda, Davide, Cassia, Matthias A, Vercelloni, Paolo G, Calatroni, Marta, Bettiol, Alessandra, Esposito, Pasquale, Murtas, Corrado, Alberici, Federico, Maritati, Federica, Manenti, Lucio, Palmisano, Alessandra, Emmi, Giacomo, Romagnani, Paola, Moroni, Gabriella, Gregorini, Gina, Sinico, Renato A, Jayne, David R W, Vaglio, Augusto, Trivioli, G, Gopaluni, S, Urban, M, Gianfreda, D, Cassia, M, Vercelloni, P, Calatroni, M, Bettiol, A, Esposito, P, Murtas, C, Alberici, F, Maritati, F, Manenti, L, Palmisano, A, Emmi, G, Romagnani, P, Moroni, G, Gregorini, G, Sinico, R, Jayne, D, Vaglio, A, Trivioli, Giorgio, Gopaluni, Seerapani, Urban, Maria L, Gianfreda, Davide, Cassia, Matthias A, Vercelloni, Paolo G, Calatroni, Marta, Bettiol, Alessandra, Esposito, Pasquale, Murtas, Corrado, Alberici, Federico, Maritati, Federica, Manenti, Lucio, Palmisano, Alessandra, Emmi, Giacomo, Romagnani, Paola, Moroni, Gabriella, Gregorini, Gina, Sinico, Renato A, Jayne, David R W, and Vaglio, Augusto

Abstract

Background. Although rapidly progressive glomerulonephritis is the main renal phenotype of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), slow renal disease progression is sometimes observed. These forms have been rarely discussed; we analysed their prevalence, clinico-pathological characteristics and outcome. Methods. We screened patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis followed at seven referral centres and selected those with estimated glomerular filtration rate (eGFR) reduction [removed]25% as compared with diagnosis, while 4/34 (12%) had started RRT. Conclusions. AAV may present with slow renal disease progression; this subset is hallmarked by advanced age at diagnosis, positive MPO-ANCA, subclinical interstitial lung lesions and chronic damage at kidney biopsy. Partial renal recovery may occur following immunosuppression.

Published
2021

19. Brescia 'incontournable'. La promozione online del capoluogo e del suo territorio in lingua francese

Author

Gregorini, G, Semeraro, R, Cigada, Sara, cigada (ORCID:0000-0003-4474-6616), Gregorini, G, Semeraro, R, Cigada, Sara, and cigada (ORCID:0000-0003-4474-6616)

Abstract

In French websites and platforms dedicated to tourism promotion (Le Guide Vert Michelin, Le Routard, Le Petit Futé), the word "incontournable" is very frequent to identify an experience thet the tourist should absolutely not miss. It is also a key-word, useful to categorize and promote "special" destinations. The contribution inquires how the word "incontournable" changed its semantics in the last years, to become a key-word in tourism discourse. Empirical data are related to a specific area in Lombardy (North Italy - the city of Brescia and its region), rich in attractions but not adequately represented by online resources for tourism.

Published
2021

20. Accounting for controlling, accounting for giving: the Pavonians and their vocational school in nineteenth-century Brescia

Author

Gregorini, Giovanni, Semeraro, Riccardo, Gregorini G (ORCID:0000-0003-0652-4852), Semeraro R (ORCID:0000-0003-4181-1064), Gregorini, Giovanni, Semeraro, Riccardo, Gregorini G (ORCID:0000-0003-0652-4852), and Semeraro R (ORCID:0000-0003-4181-1064)

Abstract

Scientific investigation on the accounting practices adopted by educational institutions is attracting growing interest at the international level and this research line is intersecting with other innovative ones. This paper, which adopts an Anglo-Foucauldian approach integrated with the asymmetrical exchange perspective, analyzes the accounting practices employed by a religious congregation for the management of a pioneering vocational training school in nineteenth-century Brescia. The study demonstrates the importance of these practices, not only for the ordinary administration of the school, but also for addressing problems of educational poverty in a governmentality perspective integrated with the logic of giving.

Published
2021

21. Accounting, educational institutions and local government in Italy (1886–1907)

Author

Semeraro, Riccardo, Gregorini, Giovanni, Semeraro, R (ORCID:0000-0003-4181-1064), Gregorini, G (ORCID:0000-0003-0652-4852), Semeraro, Riccardo, Gregorini, Giovanni, Semeraro, R (ORCID:0000-0003-4181-1064), and Gregorini, G (ORCID:0000-0003-0652-4852)

Abstract

Although little is known about accounting activities within educational institutions, even less is known about their relevance to local governments. By adopting an Anglo-Foucauldian perspective, an archival-based study is conducted in this article to investigate the accounting practices adopted by a religious congregation for the management of two vocational schools in Brescia, Italy, between 1886 and 1907. In such a context, which lacked an efficient and effective educational system and underwent socio-economic changes as a result of an incipient industrialisation process, the accounting practices proved to be crucial not only to ensure the proper functioning of the institutions under investigation, but also to deal with educational poverty. This study demonstrates that accounting practices have a constitutive role in pursuing equilibrium strategies within the dynamics of local government.

Published
2021

22. Cluster analysis identifies distinct pathogenetic patterns in c3 glomerulopathies/immune complex–Mediated membranoproliferative GN

Author

Iatropoulos, P, Daina, E, Curreri, M, Piras, R, Valoti, E, Mele, C, Bresin, E, Gamba, S, Alberti, M, Breno, M, Perna, A, Bettoni, S, Sabadini, E, Murer, L, Vivarelli, M, Noris, M, Remuzzi, G, Bottanelli, L, Donadelli, R, Cuccarolo, P, Abbate, M, Carrara, C, Cannata, A, Ferrari, S, Gaspari, F, Stucchi, N, Bassani, C, Lena, M, Omati, G, Taruscia, D, Bellantuono, R, Giordano, M, Messina, G, Caruso, M, Gotti, E, Mescia, F, Perticucci, E, Schieppati, A, Verdoni, L, Berto, M, Baraldi, O, Montini, G, Pasini, A, Passler, W, Degasperi, T, Gaggiotti, M, Gregorini, G, Miglietti, N, Guarnieri, A, Cirami, L, Roperto, R, Di Giorgio, G, Barbano, G, Innocenti, M, Ghiggeri, G, Magnasco, A, Rolla, D, Casartelli, D, Lambertini, D, Maggio, M, Cosci, P, Conti, G, Amar, K, Ardissino, G, Marinosci, A, Sinico, R, Montoli, A, Bonucchi, D, Facchini, F, Furci, L, Ferretti, A, Nuzzi, F, Pecoraro, C, Visciano, B, Canavese, C, Radin, E, Stratta, P, Nordio, M, Benetti, E, Parolin, M, Alberici, F, Manenti, L, Brugnano, R, Manenti, F, Capitanini, A, Emma, F, Massella, L, Rosa, M, Mazzon, M, Basso, E, Besso, L, Lavacca, A, Mella, A, Bertero, M, Coppo, R, Peruzzi, L, Porcellini, M, Piccoli, G, Clari, R, Pasi, A, Gangemi, C, Alfandary, H, Dagan, A, Conceiçao, M, Sameiro, F, Croze, L, Malvezzi, P, Tsygin, A, Zelan, B, Nastasi, N, Iatropoulos, Paraskevas, Daina, Erica, Curreri, Manuela, Piras, Rossella, Valoti, Elisabetta, Mele, Caterina, Bresin, Elena, Gamba, Sara, Alberti, Marta, Breno, Matteo, Perna, Annalisa, Bettoni, Serena, Sabadini, Ettore, Murer, Luisa, Vivarelli, Marina, Noris, Marina, Remuzzi, Giuseppe, Bottanelli, L., Donadelli, R., Cuccarolo, P., Abbate, M., Carrara, C., Cannata, A., Ferrari, S., Gaspari, F., Stucchi, N., Bassani, C., Lena, M., Omati, G., Taruscia, D., Bellantuono, R., Giordano, M., Messina, G., Caruso, M., Gotti, E., Mescia, F., Perticucci, E., Schieppati, A., Verdoni, L., Berto, M., Baraldi, O., Montini, G., Pasini, A., Passler, W., Degasperi, T., Gaggiotti, M., Gregorini, G., Miglietti, N., Guarnieri, A., Cirami, L., Roperto, R. M., Di Giorgio, G., Barbano, G., Innocenti, M. L. D., Ghiggeri, G. M., Magnasco, A., Rolla, D., Casartelli, D., Lambertini, D., Maggio, M., Cosci, P. M., Conti, G., Amar, K., Ardissino, G., Marinosci, A., Sinico, R. A., Montoli, A., Bonucchi, D., Facchini, F., Furci, L., Ferretti, A., Nuzzi, F., Pecoraro, C., Visciano, B., Canavese, C., Radin, E., Stratta, P., Nordio, M., Benetti, E., Parolin, M., Alberici, F., Manenti, L., Brugnano, R., Manenti, F., Capitanini, A., Emma, F., Massella, L., Rosa, M., Mazzon, M., Basso, E., Besso, L., Lavacca, A., Mella, A., Bertero, M., Coppo, R., Peruzzi, L., Porcellini, M. G., Piccoli, G. B., Clari, R., Pasi, A., Gangemi, C., Alfandary, H., Dagan, A., Conceiçao, M., Sameiro, F. M., Croze, L., Malvezzi, P., Tsygin, A., Zelan, B., Nastasi, null, Iatropoulos, P, Daina, E, Curreri, M, Piras, R, Valoti, E, Mele, C, Bresin, E, Gamba, S, Alberti, M, Breno, M, Perna, A, Bettoni, S, Sabadini, E, Murer, L, Vivarelli, M, Noris, M, Remuzzi, G, Bottanelli, L, Donadelli, R, Cuccarolo, P, Abbate, M, Carrara, C, Cannata, A, Ferrari, S, Gaspari, F, Stucchi, N, Bassani, C, Lena, M, Omati, G, Taruscia, D, Bellantuono, R, Giordano, M, Messina, G, Caruso, M, Gotti, E, Mescia, F, Perticucci, E, Schieppati, A, Verdoni, L, Berto, M, Baraldi, O, Montini, G, Pasini, A, Passler, W, Degasperi, T, Gaggiotti, M, Gregorini, G, Miglietti, N, Guarnieri, A, Cirami, L, Roperto, R, Di Giorgio, G, Barbano, G, Innocenti, M, Ghiggeri, G, Magnasco, A, Rolla, D, Casartelli, D, Lambertini, D, Maggio, M, Cosci, P, Conti, G, Amar, K, Ardissino, G, Marinosci, A, Sinico, R, Montoli, A, Bonucchi, D, Facchini, F, Furci, L, Ferretti, A, Nuzzi, F, Pecoraro, C, Visciano, B, Canavese, C, Radin, E, Stratta, P, Nordio, M, Benetti, E, Parolin, M, Alberici, F, Manenti, L, Brugnano, R, Manenti, F, Capitanini, A, Emma, F, Massella, L, Rosa, M, Mazzon, M, Basso, E, Besso, L, Lavacca, A, Mella, A, Bertero, M, Coppo, R, Peruzzi, L, Porcellini, M, Piccoli, G, Clari, R, Pasi, A, Gangemi, C, Alfandary, H, Dagan, A, Conceiçao, M, Sameiro, F, Croze, L, Malvezzi, P, Tsygin, A, Zelan, B, Nastasi, N, Iatropoulos, Paraskevas, Daina, Erica, Curreri, Manuela, Piras, Rossella, Valoti, Elisabetta, Mele, Caterina, Bresin, Elena, Gamba, Sara, Alberti, Marta, Breno, Matteo, Perna, Annalisa, Bettoni, Serena, Sabadini, Ettore, Murer, Luisa, Vivarelli, Marina, Noris, Marina, Remuzzi, Giuseppe, Bottanelli, L., Donadelli, R., Cuccarolo, P., Abbate, M., Carrara, C., Cannata, A., Ferrari, S., Gaspari, F., Stucchi, N., Bassani, C., Lena, M., Omati, G., Taruscia, D., Bellantuono, R., Giordano, M., Messina, G., Caruso, M., Gotti, E., Mescia, F., Perticucci, E., Schieppati, A., Verdoni, L., Berto, M., Baraldi, O., Montini, G., Pasini, A., Passler, W., Degasperi, T., Gaggiotti, M., Gregorini, G., Miglietti, N., Guarnieri, A., Cirami, L., Roperto, R. M., Di Giorgio, G., Barbano, G., Innocenti, M. L. D., Ghiggeri, G. M., Magnasco, A., Rolla, D., Casartelli, D., Lambertini, D., Maggio, M., Cosci, P. M., Conti, G., Amar, K., Ardissino, G., Marinosci, A., Sinico, R. A., Montoli, A., Bonucchi, D., Facchini, F., Furci, L., Ferretti, A., Nuzzi, F., Pecoraro, C., Visciano, B., Canavese, C., Radin, E., Stratta, P., Nordio, M., Benetti, E., Parolin, M., Alberici, F., Manenti, L., Brugnano, R., Manenti, F., Capitanini, A., Emma, F., Massella, L., Rosa, M., Mazzon, M., Basso, E., Besso, L., Lavacca, A., Mella, A., Bertero, M., Coppo, R., Peruzzi, L., Porcellini, M. G., Piccoli, G. B., Clari, R., Pasi, A., Gangemi, C., Alfandary, H., Dagan, A., Conceiçao, M., Sameiro, F. M., Croze, L., Malvezzi, P., Tsygin, A., Zelan, B., and Nastasi, null

Abstract

Membranoproliferative GN (MPGN) was recently reclassified as alternative pathway complement–mediated C3 glomerulopathy (C3G) and immune complex–mediated membranoproliferative GN (IC-MPGN). However, genetic and acquired alternative pathway abnormalities are also observed in IC-MPGN. Here, we explored the presence of distinct disease entities characterized by specific pathophysiologic mechanisms. We performed unsupervised hierarchical clustering, a data-driven statistical approach, on histologic, genetic, and clinical data and data regarding serum/plasma complement parameters from 173 patients with C3G/IC-MPGN. This approach divided patients into four clusters, indicating the existence of four different pathogenetic patterns. Specifically, this analysis separated patients with fluid-phase complement activation (clusters 1–3) who had low serum C3 levels and a high prevalence of genetic and acquired alternative pathway abnormalities from patients with solid-phase complement activation (cluster 4) who had normal or mildly altered serum C3, late disease onset, and poor renal survival. In patients with fluid-phase complement activation, those in clusters 1 and 2 had massive activation of the alternative pathway, including activation of the terminal pathway, and the highest prevalence of subendothelial deposits, but those in cluster 2 had additional activation of the classic pathway and the highest prevalence of nephrotic syndrome at disease onset. Patients in cluster 3 had prevalent activation of C3 convertase and highly electron-dense intramembranous deposits. In addition, we provide a simple algorithm to assign patients with C3G/IC-MPGN to specific clusters. These distinct clusters may facilitate clarification of disease etiology, improve risk assessment for ESRD, and pave the way for personalized treatment.

Published
2018

23. Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis

Author

Walsh, M, Merkel, PA, Peh, C-A, Szpirt, WM, Puéchal, X, Fujimoto, S, Hawley, CM, Khalidi, N, Floßmann, O, Wald, R, Girard, LP, Levin, A, Gregorini, G, Harper, L, Clark, WF, Pagnoux, C, Specks, U, Smyth, L, Tesar, V, Ito-Ihara, T, de Zoysa, JR, Szczeklik, W, Flores-Suárez, LF, Carette, S, Guillevin, L, Pusey, CD, Casian, AL, Brezina, B, Mazzetti, A, McAlear, CA, Broadhurst, E, Reidlinger, D, Mehta, S, Ives, N, Jayne, DRW, Walsh, M, Merkel, PA, Peh, C-A, Szpirt, WM, Puéchal, X, Fujimoto, S, Hawley, CM, Khalidi, N, Floßmann, O, Wald, R, Girard, LP, Levin, A, Gregorini, G, Harper, L, Clark, WF, Pagnoux, C, Specks, U, Smyth, L, Tesar, V, Ito-Ihara, T, de Zoysa, JR, Szczeklik, W, Flores-Suárez, LF, Carette, S, Guillevin, L, Pusey, CD, Casian, AL, Brezina, B, Mazzetti, A, McAlear, CA, Broadhurst, E, Reidlinger, D, Mehta, S, Ives, N, and Jayne, DRW

Abstract

Death from any cause or ESKD occurred in 100 of 352 patients (28.4%) in the plasma-exchange group and in 109 of 352 patients (31.0%) in the control group (hazard ratio, 0.86; 95% confidence interval [CI], 0.65 to 1.13; P=0.27). The results were similar in subgroup analyses and in analyses of secondary outcomes. We also assessed the noninferiority of a reduced-dose regimen of glucocorticoids to a standard-dose regimen, using a noninferiority margin of 11 percentage points. Death from any cause or ESKD occurred in 92 of 330 patients (27.9%) in the reduced-dose group and in 83 of 325 patients (25.5%) in the standard-dose group (absolute risk difference, 2.3 percentage points; 90% CI, −3.4 to 8.0), which met the criterion for noninferiority. Serious infections at 1 year were less common in the reduced-dose group than in the standard-dose group (incidence rate ratio, 0.69; 95% CI, 0.52 to 0.93), but other secondary outcomes were similar in the two groups.

Published
2020

26. FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis

Author

Alberici, F, Bonatti, F, Adorni, A, Daminelli, G, Sinico, R, Gregorini, G, Marvisi, C, Fenaroli, P, Peyronel, F, Maritati, F, Palmisano, A, Urban, M, Percesepe, A, Emmi, G, Martorana, D, Vaglio, A, Alberici, Federico, Bonatti, Francesco, Adorni, Alessia, Daminelli, Giulia, Sinico, Renato A, Gregorini, Gina, Marvisi, Chiara, Fenaroli, Paride, Peyronel, Francesco, Maritati, Federica, Palmisano, Alessandra, Urban, Maria Letizia, Percesepe, Antonio, Emmi, Giacomo, Martorana, Davide, Vaglio, Augusto, Alberici, F, Bonatti, F, Adorni, A, Daminelli, G, Sinico, R, Gregorini, G, Marvisi, C, Fenaroli, P, Peyronel, F, Maritati, F, Palmisano, A, Urban, M, Percesepe, A, Emmi, G, Martorana, D, Vaglio, A, Alberici, Federico, Bonatti, Francesco, Adorni, Alessia, Daminelli, Giulia, Sinico, Renato A, Gregorini, Gina, Marvisi, Chiara, Fenaroli, Paride, Peyronel, Francesco, Maritati, Federica, Palmisano, Alessandra, Urban, Maria Letizia, Percesepe, Antonio, Emmi, Giacomo, Martorana, Davide, and Vaglio, Augusto

Published
2020

28. SAT0243 SUBPHENOTYPES IN POLYARTERITIS NODOSA (PAN): TARGET ORGAN ASSOCIATIONS OF A WORLDWIDE COLLABORATION STUDY

Author

Karadag, O., primary, Bolek, E. C., additional, Furuta, S., additional, Emmi, G., additional, Hocevar, A., additional, Hinojosa-Azaola, A., additional, Mohammad, A. J., additional, Ugurlu, S., additional, Alibaz-Oner, F., additional, Yazici, A., additional, Quartuccio, L., additional, Bozzolo, E., additional, Dagna, L., additional, Ramirez, G. A., additional, Cantarini, L., additional, Gregorini, G., additional, Guido, J., additional, Monti, S., additional, Martin-Nares, E., additional, Schiavon, F., additional, Padoan, R., additional, Kono, H., additional, Vaglio, A., additional, Kiliçkap, S., additional, Ertenli, A. İ., additional, Direskeneli, H., additional, Özen, S., additional, and Jayne, D., additional

Published
2020
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30. Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Author

Lyons, P.A., Peters, J.E., Alberici, F., Liley, J., Coulson, R.M.R., Astle, W., Baldini, C., Bonatti, F., Cid, M.C., Elding, H., Emmi, G., Epplen, J., Guillevin, L., Jayne, D.R.W., Jiang, T., Gunnarsson, I., Lamprecht, P., Leslie, S., Little, M.A., Martorana, D., Moosig, F., Neumann, T., Ohlsson, S., Quickert, S., Ramirez, G.A., Rewerska, B., Schett, G., Sinico, R.A., Szczeklik, W., Tesar, V., Vukcevic, D., Akil, M., Barratt, J., Basu, N., Butterworth, A.S., Bruce, I., Clarkson, M., Conlon, N., DasGupta, B., Doulton, T.W.R., Espígol-Frigolé, Georgina, Flossmann, O., Gabrielli, A., Gasior, J., Gregorini, G., Guida, G., Hernández Rodríguez, José, Hruskova, Z., Hudson, A., Knight, A., Lanyon, P., Luqmani, R., Magliano, M., Manfredi, A.A., Marguerie, C., Maritati, F., Marvisi, C., McHugh, N.J., Molloy, E., Motyer, A., Mukhtyar, C., Padyukov, L., Pesci, A., Prieto-Gonzalez, S., Ramentol-Sintas, Marc, Reis, P., Roccatello, D., Rovere-Querini, P., Salvarani, C., Santarsia, F., Solans-Laque, R., Soranzo, N., Taylor, J., Wessels, J., Zwerina, J., Terrier, B., Watts, R.A., Vaglio, A., Holle, J.U., Wallace, C., Smith, K.G.C., and Universitat Autònoma de Barcelona

Subjects
Eosinophils, Genetic Loci, Granulomatosis with Polyangiitis, Humans, Genetic Predisposition to Disease, Mendelian Randomization Analysis, Genetic Association Studies, Antibodies, Antineutrophil Cytoplasmic, Genome-Wide Association Study
Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association study in 676 EGPA cases and 6809 controls, that identifies 4 EGPA-associated loci through conventional case-control analysis, and 4 additional associations through a conditional false discovery rate approach. Many variants are also associated with asthma and six are associated with eosinophil count in the general population. Through Mendelian randomisation, we show that a primary tendency to eosinophilia contributes to EGPA susceptibility. Stratification by ANCA reveals that EGPA comprises two genetically and clinically distinct syndromes. MPO+ ANCA EGPA is an eosinophilic autoimmune disease sharing certain clinical features and an HLA-DQ association with MPO+ ANCA-associated vasculitis, while ANCA-negative EGPA may instead have a mucosal/barrier dysfunction origin. Four candidate genes are targets of therapies in development, supporting their exploration in EGPA.

Published
2019

32. Tito Prospero Martinengo, monaco bresciano, erudito e poeta

Author

Canova A., Gregorini G., Ghidini, Ottavio, Ottavio Ghidini (ORCID:0000-0002-9742-0575), Canova A., Gregorini G., Ghidini, Ottavio, and Ottavio Ghidini (ORCID:0000-0002-9742-0575)

Abstract

Vita e opere di Tito Prospero Martinengo, monaco cassinese bresciano della seconda metà del Cinquecento.

Published
2019

33. Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Author

Lyons, P, Peters, J, Alberici, F, Liley, J, Coulson, R, Astle, W, Baldini, C, Bonatti, F, Cid, M, Elding, H, Emmi, G, Epplen, J, Guillevin, L, Jayne, D, Jiang, T, Gunnarsson, I, Lamprecht, P, Leslie, S, Little, M, Martorana, D, Moosig, F, Neumann, T, Ohlsson, S, Quickert, S, Ramierez, G, Rewerska, B, Schett, G, Sinico, R, Szczeklik, W, Tesar, V, Vukcevic, D, Akil, M, Barratt, J, Basu, N, Butterworth, A, Bruce, I, Clarkson, M, Conlon, N, Dasgupta, B, Doulton, T, Espigol-Frigole, G, Flossmann, O, Gabrielli, A, Gasior, J, Gregorini, G, Guida, G, Hernandez-Rodriguez, J, Hruskova, Z, Hudson, A, Knight, A, Lanyon, P, Luqmani, R, Magliano, M, Manfredi, A, Marguerie, C, Maritati, F, Marvisi, C, Mchugh, N, Molloy, E, Motyer, A, Mukhtyar, C, Padyukov, L, Pesci, A, Prieto-Gonzalez, S, Ramentol-Sintas, M, Reis, P, Roccatello, D, Rovere-Querini, P, Salvarani, C, Santarsia, F, Solans-Laque, R, Soranzo, N, Taylor, J, Wessels, J, Zwerina, J, Terrier, B, Watts, R, Vaglio, A, Holle, J, Wallace, C, Smith, K, Lyons, PA, Peters, JE, Cid, MC, Little, MA, Ramierez, GA, Butterworth, AS, DasGupta, B, Doulton, TWR, Manfredi, AA, McHugh, NJ, Watts, RA, Holle, JU, Smith, KGC, Lyons, P, Peters, J, Alberici, F, Liley, J, Coulson, R, Astle, W, Baldini, C, Bonatti, F, Cid, M, Elding, H, Emmi, G, Epplen, J, Guillevin, L, Jayne, D, Jiang, T, Gunnarsson, I, Lamprecht, P, Leslie, S, Little, M, Martorana, D, Moosig, F, Neumann, T, Ohlsson, S, Quickert, S, Ramierez, G, Rewerska, B, Schett, G, Sinico, R, Szczeklik, W, Tesar, V, Vukcevic, D, Akil, M, Barratt, J, Basu, N, Butterworth, A, Bruce, I, Clarkson, M, Conlon, N, Dasgupta, B, Doulton, T, Espigol-Frigole, G, Flossmann, O, Gabrielli, A, Gasior, J, Gregorini, G, Guida, G, Hernandez-Rodriguez, J, Hruskova, Z, Hudson, A, Knight, A, Lanyon, P, Luqmani, R, Magliano, M, Manfredi, A, Marguerie, C, Maritati, F, Marvisi, C, Mchugh, N, Molloy, E, Motyer, A, Mukhtyar, C, Padyukov, L, Pesci, A, Prieto-Gonzalez, S, Ramentol-Sintas, M, Reis, P, Roccatello, D, Rovere-Querini, P, Salvarani, C, Santarsia, F, Solans-Laque, R, Soranzo, N, Taylor, J, Wessels, J, Zwerina, J, Terrier, B, Watts, R, Vaglio, A, Holle, J, Wallace, C, Smith, K, Lyons, PA, Peters, JE, Cid, MC, Little, MA, Ramierez, GA, Butterworth, AS, DasGupta, B, Doulton, TWR, Manfredi, AA, McHugh, NJ, Watts, RA, Holle, JU, and Smith, KGC

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association study in 676 EGPA cases and 6809 controls, that identifies 4 EGPA-associated loci through conventional case-control analysis, and 4 additional associations through a conditional false discovery rate approach. Many variants are also associated with asthma and six are associated with eosinophil count in the general population. Through Mendelian randomisation, we show that a primary tendency to eosinophilia contributes to EGPA susceptibility. Stratification by ANCA reveals that EGPA comprises two genetically and clinically distinct syndromes. MPO+ ANCA EGPA is an eosinophilic autoimmune disease sharing certain clinical features and an HLA-DQ association with MPO+ ANCA-associated vasculitis, while ANCA-negative EGPA may instead have a mucosal/barrier dysfunction origin. Four candidate genes are targets of therapies in development, supporting their exploration in EGPA.

Published
2019

34. Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status

Author

Lyons, PA, Peters, JE, Alberici, F, Liley, J, Coulson, RMR, Astle, W, Baldini, C, Bonatti, F, Cid, MC, Elding, H, Emmi, G, Epplen, J, Guillevin, L, Jayne, DRW, Jiang, T, Gunnarsson, I, Lamprecht, P, Leslie, S, Little, MA, Martorana, D, Moosig, F, Neumann, T, Ohlsson, S, Quickert, S, Ramirez, GA, Rewerska, B, Schett, G, Sinico, RA, Szczeklik, W, Tesar, V, Vukcevic, D, Akil, M, Barratt, J, Basu, N, Butterworth, AS, Bruce, I, Clarkson, M, Conlon, N, DasGupta, B, Doulton, TWR, Espigol-Frigole, G, Flossmann, O, Gabrielli, A, Gasior, J, Gregorini, G, Guida, G, Hernandez-Rodriguez, J, Hruskova, Z, Hudson, A, Knight, A, Lanyon, P, Luqmani, R, Magliano, M, Manfredi, AA, Marguerie, C, Maritati, F, Marvisi, C, McHugh, NJ, Molloy, E, Motyer, A, Mukhtyar, C, Padyukov, L, Pesci, A, Prieto-Gonzalez, S, Ramentol-Sintas, M, Reis, P, Roccatello, D, Rovere-Querini, P, Salvarani, C, Santarsia, F, Solans-Laque, R, Soranzo, N, Taylor, J, Wessels, J, Zwerina, J, Terrier, B, Watts, RA, Vaglio, A, Holle, JU, Wallace, C, Smith, KGC, Lyons, PA, Peters, JE, Alberici, F, Liley, J, Coulson, RMR, Astle, W, Baldini, C, Bonatti, F, Cid, MC, Elding, H, Emmi, G, Epplen, J, Guillevin, L, Jayne, DRW, Jiang, T, Gunnarsson, I, Lamprecht, P, Leslie, S, Little, MA, Martorana, D, Moosig, F, Neumann, T, Ohlsson, S, Quickert, S, Ramirez, GA, Rewerska, B, Schett, G, Sinico, RA, Szczeklik, W, Tesar, V, Vukcevic, D, Akil, M, Barratt, J, Basu, N, Butterworth, AS, Bruce, I, Clarkson, M, Conlon, N, DasGupta, B, Doulton, TWR, Espigol-Frigole, G, Flossmann, O, Gabrielli, A, Gasior, J, Gregorini, G, Guida, G, Hernandez-Rodriguez, J, Hruskova, Z, Hudson, A, Knight, A, Lanyon, P, Luqmani, R, Magliano, M, Manfredi, AA, Marguerie, C, Maritati, F, Marvisi, C, McHugh, NJ, Molloy, E, Motyer, A, Mukhtyar, C, Padyukov, L, Pesci, A, Prieto-Gonzalez, S, Ramentol-Sintas, M, Reis, P, Roccatello, D, Rovere-Querini, P, Salvarani, C, Santarsia, F, Solans-Laque, R, Soranzo, N, Taylor, J, Wessels, J, Zwerina, J, Terrier, B, Watts, RA, Vaglio, A, Holle, JU, Wallace, C, and Smith, KGC

Abstract

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association study in 676 EGPA cases and 6809 controls, that identifies 4 EGPA-associated loci through conventional case-control analysis, and 4 additional associations through a conditional false discovery rate approach. Many variants are also associated with asthma and six are associated with eosinophil count in the general population. Through Mendelian randomisation, we show that a primary tendency to eosinophilia contributes to EGPA susceptibility. Stratification by ANCA reveals that EGPA comprises two genetically and clinically distinct syndromes. MPO+ ANCA EGPA is an eosinophilic autoimmune disease sharing certain clinical features and an HLA-DQ association with MPO+ ANCA-associated vasculitis, while ANCA-negative EGPA may instead have a mucosal/barrier dysfunction origin. Four candidate genes are targets of therapies in development, supporting their exploration in EGPA.

Published
2019

35. FP165 Slowly progressive anca-associated glomerulonephritis: a multicentre study

Author

Trivioli, G, Gopaluni, S, Urban, M, Gianfreda, D, Cassia, M, Vercelloni, P, Calatroni, M, Esposito, P, Murtas, C, Alberici, F, Moroni, G, Gregorini, G, Sinico, R, Jayne, D, Vaglio, A, Urban, ML, Cassia, MA, Vercelloni, PG, Sinico, RA, Trivioli, G, Gopaluni, S, Urban, M, Gianfreda, D, Cassia, M, Vercelloni, P, Calatroni, M, Esposito, P, Murtas, C, Alberici, F, Moroni, G, Gregorini, G, Sinico, R, Jayne, D, Vaglio, A, Urban, ML, Cassia, MA, Vercelloni, PG, and Sinico, RA

Published
2019

36. 162. Cluster analysis to explore clinical subclassification of eosinophilic granulomatosis with polyangiitis (churg–strauss)

Author

Rubenstein, E, Maldini, C, Vaglio, A, Bottero, P, Bremer, P, Emmi, G, Fraticelli, P, Gioffredi, A, Gregorini, G, Grosskreutz, J, Guida, G, Hellmich, B, Kroegel, C, Maritati, F, Pesci, A, Resche-Rigon, M, Saadoun, D, Sinico, R, Sokolowska, B, Szczeklik, W, Zwerina, J, Moosig, F, Neumann, T, Mahr, A, Rubenstein, Emma, Maldini, Carla, Vaglio, Augusto, Bottero, Paolo, Bremer, Phillip, Emmi, Giacomo, Fraticelli, Paolo, Gioffredi, Andrea, Gregorini, Gina, Grosskreutz, Julian, Guida, Giuseppe, Hellmich, Bernhard, Kroegel, Claus, Maritati, Federica, Pesci, Alberto, Resche-Rigon, Matthieu, Saadoun, David, Sinico, Renato, Sokolowska, Barbara, Szczeklik, Wojciech, Zwerina, Jochen, Moosig, Frank, Neumann, Thomas, Mahr, Alfred, Rubenstein, E, Maldini, C, Vaglio, A, Bottero, P, Bremer, P, Emmi, G, Fraticelli, P, Gioffredi, A, Gregorini, G, Grosskreutz, J, Guida, G, Hellmich, B, Kroegel, C, Maritati, F, Pesci, A, Resche-Rigon, M, Saadoun, D, Sinico, R, Sokolowska, B, Szczeklik, W, Zwerina, J, Moosig, F, Neumann, T, Mahr, A, Rubenstein, Emma, Maldini, Carla, Vaglio, Augusto, Bottero, Paolo, Bremer, Phillip, Emmi, Giacomo, Fraticelli, Paolo, Gioffredi, Andrea, Gregorini, Gina, Grosskreutz, Julian, Guida, Giuseppe, Hellmich, Bernhard, Kroegel, Claus, Maritati, Federica, Pesci, Alberto, Resche-Rigon, Matthieu, Saadoun, David, Sinico, Renato, Sokolowska, Barbara, Szczeklik, Wojciech, Zwerina, Jochen, Moosig, Frank, Neumann, Thomas, and Mahr, Alfred

Published
2019

37. Presentazione

Author

Ritrovato E, Gregorini G., Taccolini, Mario, Taccolini Mario (ORCID:0000-0002-5687-2778), Ritrovato E, Gregorini G., Taccolini, Mario, and Taccolini Mario (ORCID:0000-0002-5687-2778)

Abstract

Presentazione della raccolta di saggi e dell'attività SISE

Published
2019

38. Destini legati. Lasciti e pratiche economiche nelle chiese italiane tra XIX e XX secolo: il caso di Mondovì

Author

Semeraro, Riccardo, Gregorini, Giovanni, Semeraro, R (ORCID:0000-0003-4181-1064), Gregorini, G (ORCID:0000-0003-0652-4852), Semeraro, Riccardo, Gregorini, Giovanni, Semeraro, R (ORCID:0000-0003-4181-1064), and Gregorini, G (ORCID:0000-0003-0652-4852)

Abstract

In the Italian post-unification period, endowments for charitable and religious purposes, together with real estate owned by ecclesiastical bodies, were involved in a large policy of suppression and forfeiture. In order to protect these resources, the Catholic Church established diocesan endowment funds. These also had the objective of enhancing the resources in economic terms by producing income and demonstrating that, by fulfilling the intentions of the donors, they could generate positive externalities. This paper focuses on the case of the diocese of Mondovì (modern-day provinces of Cuneo and Savona) and offers insights into the financial functioning of endowments in the late modern period, the strategies adopted to manage them, and the new relationships that characterized the people and institutions involved in their dynamics. By delving into these aspects, the article sheds light on the creation process of a religious welfare model and provides new interpretative elements for the understanding of social Catholicism.

Published
2019

39. Manifestazioni di arte rupestre nel territorio di Paspardo. Le ricerche degli ultimi anni

Author

Canova, A, Gregorini G, Fossati, Angelo Eugenio, Fossati Angelo Eugenio (ORCID:0000-0003-4229-9488), Canova, A, Gregorini G, Fossati, Angelo Eugenio, and Fossati Angelo Eugenio (ORCID:0000-0003-4229-9488)

Abstract

The paper deals with the state of reasearch of the Rock Art in the Municipality of Paspardo, Valcamonica. These researches are continuously going on from 1984 bringing to light several rocks engraved in prehistoric times, from Neolithic to Iron Age. The paper focuses on the research of the last years

Published
2019

40. Giovanni de Nuxigia, copista e cancelliere visconteo

Author

Canova, A., Gregorini, G., Gavinelli, Simona, Simona Gavinelli (ORCID:0000-0002-9999-8311), Canova, A., Gregorini, G., Gavinelli, Simona, and Simona Gavinelli (ORCID:0000-0002-9999-8311)

Abstract

La versatilità dei notai lombardi, in carriera presso la nascente cancelleria viscontea, che alternavano la prassi professionale all'attività di copisti librari, come dimostra il caso di Giovanni de Nuxigia

Published
2019

41. The Italian Gun-making District from a Long-term Perspective. Roots, Turning Points, Evolutionary Factors

Author

Canova, A, Gregorini, G, Semeraro, Riccardo, Semeraro, R (ORCID:0000-0003-4181-1064), Canova, A, Gregorini, G, Semeraro, Riccardo, and Semeraro, R (ORCID:0000-0003-4181-1064)

Abstract

The aim of this study is to reconstruct and reinterpret the roots and evolution of the Italian gun-making district. Focusing on the phases that preceded the postwar development, the intention is to analyze the multiple key social and economic factors that crucially influenced the evolutionary process of the local production system. The case study is considered in a long-term perspective and its characterizing evolutionary factors are analyzed in the light of contributions by economic historians on the origins and developments of industrial districts.

Published
2019

42. La resilienza dei Bresciani: il secondo dopoguerra tra laminatoi e forni elettrici

Author

Gregorini, G, Semeraro, R, Semeraro, Riccardo, Semeraro, R (ORCID:0000-0003-4181-1064), Gregorini, G, Semeraro, R, Semeraro, Riccardo, and Semeraro, R (ORCID:0000-0003-4181-1064)

Abstract

L’obiettivo del presente saggio è quello di mettere in luce il percorso di ripresa che vide protagonista il settore bresciano della lavorazione di ferro e acciaio nel secondo dopoguerra. Sulla base dei più recenti avanzamenti della letteratura economica sul concetto di resilienza, il saggio mette in luce i fattori cruciali che determinarono il rilancio della siderurgia bresciana e la nascita di quella comunità d’imprese capace, nel secondo Novecento, di giocare un ruolo rilevante nella porzione di territorio che diversi studi hanno identificato come il distretto industriale delle valli bresciane dedito alla produzione e lavorazione dei metalli.

Published
2019

43. Dagli archivi bresciani dell’Università Cattolica. Il progetto della ‘Bibliotheca Scriptorum latinorum mediae et recentioris aetatis’ in alcune lettere di Giuseppe Billanovich a Franca Brambilla Ageno (1944-1951)

Author

Canova, A, Gregorini G, Canova, Andrea, Canova Andrea (ORCID:0000-0003-0391-6092), Canova, A, Gregorini G, Canova, Andrea, and Canova Andrea (ORCID:0000-0003-0391-6092)

Abstract

Alcune lettere di Giuseppe Billanovich a Franca Brambilla Ageno permettono di portare alla luce un progetto editoriale per una collana dal titolo "Bibliotheca scriptorum latinorum mediae et recentioris aetatis", che si pone all'origine della nota "Thesaurus Mundi" (cominciato a Zurigo negli anni '50 del Novecento) e che darà luogo alla casa editrice Antenore, nei progressi in cui si definisce la Filologia medievale e umanistica novecentesca.

Published
2019

45. Cluster Analysis Identifies Distinct Pathogenetic Patterns in C3 Glomerulopathies/Immune Complex–Mediated Membranoproliferative GN

Author

Iatropoulos, Paraskevas, Daina, Erica, Curreri, Manuela, Piras, Rossella, Valoti, Elisabetta, Mele, Caterina, Bresin, Elena, Gamba, Sara, Alberti, Marta, Breno, Matteo, Perna, Annalisa, Bettoni, Serena, Sabadini, Ettore, Murer, Luisa, Vivarelli, Marina, Noris, Marina, Remuzzi, Giuseppe, Bottanelli, L., Donadelli, R., Cuccarolo, P., Abbate, M., Carrara, C., Cannata, A., Ferrari, S., Gaspari, F., Stucchi, N., Bassani, C., Lena, M., Omati, G., Taruscia, D., Bellantuono, R., Giordano, M., Messina, G., Caruso, M., Gotti, E., Mescia, F., Perticucci, E., Schieppati, A., Verdoni, L., Berto, M., Baraldi, O., Montini, G., Pasini, A., Passler, W., Degasperi, T., Gaggiotti, M., Gregorini, G., Miglietti, N., Guarnieri, A., Cirami, L., Roperto, R. M., Di Giorgio, G., Barbano, G., Innocenti, M. L. D., Ghiggeri, G. M., Magnasco, A., Rolla, D., Casartelli, D., Lambertini, D., Maggio, M., Cosci, P. M., Conti, G., Amar, K., Ardissino, G., Marinosci, A., Sinico, R. A., Montoli, A., Bonucchi, D., Facchini, F., Furci, L., Ferretti, A., Nuzzi, F., Pecoraro, C., Visciano, B., Canavese, C., Radin, E., Stratta, P., Nordio, M., Benetti, E., Parolin, M., Alberici, F., Manenti, L., Brugnano, R., Manenti, F., Capitanini, A., Emma, F., Massella, L., Rosa, M., Mazzon, M., Basso, E., Besso, L., Lavacca, A., Mella, A., Bertero, M., Coppo, R., Peruzzi, L., Porcellini, M. G., Piccoli, G. B., Clari, R., Pasi, A., Gangemi, C., Alfandary, H., Dagan, A., Conceiçao, M., Sameiro, F. M., Croze, L., Malvezzi, P., Tsygin, A., Zelan, B., Nastasi, null, Iatropoulos, P, Daina, E, Curreri, M, Piras, R, Valoti, E, Mele, C, Bresin, E, Gamba, S, Alberti, M, Breno, M, Perna, A, Bettoni, S, Sabadini, E, Murer, L, Vivarelli, M, Noris, M, Remuzzi, G, Bottanelli, L, Donadelli, R, Cuccarolo, P, Abbate, M, Carrara, C, Cannata, A, Ferrari, S, Gaspari, F, Stucchi, N, Bassani, C, Lena, M, Omati, G, Taruscia, D, Bellantuono, R, Giordano, M, Messina, G, Caruso, M, Gotti, E, Mescia, F, Perticucci, E, Schieppati, A, Verdoni, L, Berto, M, Baraldi, O, Montini, G, Pasini, A, Passler, W, Degasperi, T, Gaggiotti, M, Gregorini, G, Miglietti, N, Guarnieri, A, Cirami, L, Roperto, R, Di Giorgio, G, Barbano, G, Innocenti, M, Ghiggeri, G, Magnasco, A, Rolla, D, Casartelli, D, Lambertini, D, Maggio, M, Cosci, P, Conti, G, Amar, K, Ardissino, G, Marinosci, A, Sinico, R, Montoli, A, Bonucchi, D, Facchini, F, Furci, L, Ferretti, A, Nuzzi, F, Pecoraro, C, Visciano, B, Canavese, C, Radin, E, Stratta, P, Nordio, M, Benetti, E, Parolin, M, Alberici, F, Manenti, L, Brugnano, R, Manenti, F, Capitanini, A, Emma, F, Massella, L, Rosa, M, Mazzon, M, Basso, E, Besso, L, Lavacca, A, Mella, A, Bertero, M, Coppo, R, Peruzzi, L, Porcellini, M, Piccoli, G, Clari, R, Pasi, A, Gangemi, C, Alfandary, H, Dagan, A, Conceiçao, M, Sameiro, F, Croze, L, Malvezzi, P, Tsygin, A, Zelan, B, and Nastasi, N

Subjects
0301 basic medicine, Complement system, Glomerulonephritis, Membranoproliferative, membranoproliferative glomerulonephritis (MPGN), 030232 urology & nephrology, Disease, Antigen-Antibody Complex, Biology, Kidney, 03 medical and health sciences, 0302 clinical medicine, Glomerulopathy, Clinical Research, medicine, Dense Deposit Disease, Humans, C3 glomerulopathy, General Medicine, Complement System Proteins, C3 glomerulonephriti, medicine.disease, C3-convertase, Immune complex, 030104 developmental biology, Nephrology, Immunology, Alternative complement pathway, Nephrotic syndrome, Rare disease
Abstract

Membranoproliferative GN (MPGN) was recently reclassified as alternative pathway complement–mediated C3 glomerulopathy (C3G) and immune complex–mediated membranoproliferative GN (IC-MPGN). However, genetic and acquired alternative pathway abnormalities are also observed in IC-MPGN. Here, we explored the presence of distinct disease entities characterized by specific pathophysiologic mechanisms. We performed unsupervised hierarchical clustering, a data-driven statistical approach, on histologic, genetic, and clinical data and data regarding serum/plasma complement parameters from 173 patients with C3G/IC-MPGN. This approach divided patients into four clusters, indicating the existence of four different pathogenetic patterns. Specifically, this analysis separated patients with fluid-phase complement activation (clusters 1–3) who had low serum C3 levels and a high prevalence of genetic and acquired alternative pathway abnormalities from patients with solid-phase complement activation (cluster 4) who had normal or mildly altered serum C3, late disease onset, and poor renal survival. In patients with fluid-phase complement activation, those in clusters 1 and 2 had massive activation of the alternative pathway, including activation of the terminal pathway, and the highest prevalence of subendothelial deposits, but those in cluster 2 had additional activation of the classic pathway and the highest prevalence of nephrotic syndrome at disease onset. Patients in cluster 3 had prevalent activation of C3 convertase and highly electron-dense intramembranous deposits. In addition, we provide a simple algorithm to assign patients with C3G/IC-MPGN to specific clusters. These distinct clusters may facilitate clarification of disease etiology, improve risk assessment for ESRD, and pave the way for personalized treatment.

Published
2017

48. Clinical predictors of response to rituximab in anca-associated vasculitis: a european cohort

Author

Alberici, F, Smith, R, Cassia, M, Colombo, F., Brenna, I., Jones, R, Holle, J, Neumann, T, Gregorini, G, Bruchfeld, A, Gunnarsson, I. Ohlsson, S, Baslund, B, Tesar, V, Hruskova, Z, Cid, M, Vaglio, A, Smith, K, Jayne, D., SINICO, RENATO ALBERTO, Alberici, F, Smith, R, Cassia, M, Colombo, F, Brenna, I, Jones, R, Holle, J, Neumann, T, Gregorini, G, Sinico, R, Bruchfeld, A, Gunnarsson, I., O, S, Baslund, B, Tesar, V, Hruskova, Z, Cid, M, Vaglio, A, Smith, K, and Jayne, D

Subjects
ANCA, vasculitis, rituximab
Published
2016

49. Ruinas y Esperanza. Europa tras la Segunda Guerra Mundial

Author

Anni, R, Gregorini, G, Pasini, MP, Miranda, Ja, Semeraro, Riccardo, Semeraro, R (ORCID:0000-0003-4181-1064), Anni, R, Gregorini, G, Pasini, MP, Miranda, Ja, Semeraro, Riccardo, and Semeraro, R (ORCID:0000-0003-4181-1064)

Abstract

El artículo intenta mostrar los principales rasgos y la evolución de Europa en la posguerra.

Published
2018

50. Society and Welfare Community in Early Postwar Brescia

Author

Anni, R, Gregorini, G, Pasini, MP, Semeraro, Riccardo, Semeraro, R (ORCID:0000-0003-4181-1064), Anni, R, Gregorini, G, Pasini, MP, Semeraro, Riccardo, and Semeraro, R (ORCID:0000-0003-4181-1064)

Abstract

The paper investigates the numerous initiatives carried out in Brescia to start the reconstruction in the postwar period. The attention focusses on the very first response to the most pressing needs, as well as on the choices made in a long-term perspective. Great attention is dedicated to the role played by the Allied Military Government and Congrega della Carità Apostolica.

Published
2018

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