1. GABAergic hub neurons orchestrate synchrony in developing hippocampal networks
- Author
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Miri Goldin, Rosa Cossart, Isabel Jorquera, Adriano Augusto Cattani, Michel A. Picardo, Yehezkel Ben-Ari, Gregory Bianconi, Alfonso Represa, Paolo Bonifazi, Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université] (INMED - INSERM U1249), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Physics, Northeastern University [Boston], Tyzio, Roman, and Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)
- Subjects
Patch-Clamp Techniques ,MESH: Hippocampus ,Nerve net ,Action Potentials ,MESH: gamma-Aminobutyric Acid ,Hippocampal formation ,Hippocampus ,MESH: Synapses ,Mice ,0302 clinical medicine ,MESH: Animals ,gamma-Aminobutyric Acid ,MESH: Action Potentials ,0303 health sciences ,Multidisciplinary ,Pyramidal Cells ,Anatomy ,CA3 Region, Hippocampal ,MESH: Interneurons ,medicine.anatomical_structure ,MESH: Calcium ,GABAergic ,MESH: Axons ,Interneuron ,MESH: Rats ,[SDV.BC]Life Sciences [q-bio]/Cellular Biology ,Biology ,In Vitro Techniques ,Network topology ,MESH: Dendrites ,03 medical and health sciences ,Giant depolarizing potentials ,Interneurons ,MESH: Patch-Clamp Techniques ,medicine ,Animals ,Rats, Wistar ,MESH: Excitatory Postsynaptic Potentials ,[SDV.BC] Life Sciences [q-bio]/Cellular Biology ,MESH: Mice ,030304 developmental biology ,Quantitative Biology::Neurons and Cognition ,Excitatory Postsynaptic Potentials ,Dendrites ,MESH: Pyramidal Cells ,MESH: Rats, Wistar ,Network dynamics ,Axons ,Rats ,Functional imaging ,nervous system ,MESH: Nerve Net ,Synapses ,MESH: CA3 Region, Hippocampal ,Calcium ,Nerve Net ,Neuroscience ,030217 neurology & neurosurgery - Abstract
Coordinating Neuronal Assemblies Theoretical models predict the existence of so-called hub neurons—highly connected cells that strongly influence the synchronization of spiking activity in a large group of neurons. However, experimental evidence for the existence of these neuronal hubs is lacking. Bonifazi et al. (p. 1419 ) used high-resolution, two-photon calcium imaging to measure spontaneous calcium fluctuations in hundreds of neurons simultaneously and determined the relative timing of these fluctuations. Examination of functional connectivity maps, based on temporal correlation measurements, revealed a subpopulation of GABAergic hub neurons displaying a remarkably widespread axonal arborization that orchestrated network synchrony in developing hippocampal networks. Spontaneous network synchronizations in developing hippocampus caused giant depolarizing potentials in individual neurons, and manipulating the spike activity in potential hub cells influenced network activity.
- Published
- 2009
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