1. The Precision Toxicology initiative
- Author
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François Busquet, Jeanne Laperrouze, Katica Jankovic, Tamara Krsmanovic, Tomasz Ignasiak, Benedetta Leoni, Gordana Apic, Giovanni Asole, Roderic Guigó, Paolo Marangio, Emilio Palumbo, Silvia Perez-Lluch, Valentin Wucher, Anna Hendrika Vlot, Robert Anholt, Trudy Mackay, Beate I. Escher, Nico Grasse, Julia Huchthausen, Riccardo Massei, Thorsten Reemtsma, Stefan Scholz, Gerrit Schüürmann, Maria Bondesson, Peter Cherbas, Jonathan H. Freedman, Stephen Glaholt, Jessica Holsopple, Stephen C. Jacobson, Thomas Kaufman, Ellen Popodi, Joseph J. Shaw, Shannon Smoot, Jason M. Tennessen, Gary Churchill, Christina Cramer von Clausbruch, Thomas Dickmeis, Gaëlle Hayot, Giuseppina Pace, Ravindra Peravali, Carsten Weiss, Nadezda Cistjakova, Xin Liu, Andis Slaitas, James (Ben) Brown, Rafael Ayerbe, Joan Cabellos, Elena Cerro-Gálvez, María Diez-Ortiz, Verónica González, Rubén Martínez, Patricia Solórzano Vives, Rosemary Barnett, Thomas Lawson, Robert G. Lee, Elena Sostare, Mark Viant, Roland Grafström, Vesa Hongisto, Pekka Kohonen, Konrad Patyra, Pradeep Kumar Bhaskar, Marcial Garmendia-Cedillos, Ibraheem Farooq, Brian Oliver, Tom Pohida, Ghadi Salem, Daniel Jacobson, Elisabeth Andrews, Marianne Barnard, Aleksandra Čavoški, Anurag Chaturvedi, John K. Colbourne, David J.T. Epps, Laura Holden, Martin R. Jones, Xiaojing Li, Ferenc Müller, Agata Ormanin-Lewandowska, Luisa Orsini, Ruth Roberts, Ralf J.M. Weber, Jiarui Zhou, Mu-En Chung, Juan Carlos Gonzalez Sanchez, Gaurav D. Diwan, Gurdeep Singh, Uwe Strähle, Robert B. Russell, Dominique Batista, Susanna-Assunta Sansone, Philippe Rocca-Serra, David Du Pasquier, Gregory Lemkine, Barbara Robin-Duchesne, Andrew Tindall, Consortium, The PrecisionTox, Batista, D, Sansone, S-A, and Rocca-Serra, P
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General Medicine ,Toxicology - Abstract
The goal of PrecisionTox is to overcome conceptual barriers to replacing traditional mammalian chemical safety testing by accelerating the discovery of evolutionarily conserved toxicity pathways that are shared by descent among humans and more distantly related animals. An international consortium is systematically testing the toxicological effects of a diverse set of chemicals on a suite of five model species comprising fruit flies, nematodes, water fleas, and embryos of clawed frogs and zebrafish along with human cell lines. Multiple forms of omics and comparative toxicology data are integrated to map the evolutionary origins of biomolecular interactions that are predictive of adverse health effects, to major branches of the animal phylogeny. These conserved elements of adverse outcome pathways (AOPs) and their biomarkers are expected to provide mechanistic insight useful for regulating groups of chemicals based on their shared modes of action. PrecisionTox also aims to quantify risk variation within populations by recognizing susceptibility as a heritable trait that varies with genetic diversity. This initiative incorporates legal experts and collaborates with risk managers to address specific needs within European chemicals legislation, including the uptake of new approach methodologies (NAMs) for setting precise regulatory limits on toxic chemicals.
- Published
- 2023