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1. A Phase 1-2 Study of Imexon Plus Dacarbazine in Patients With Unresectable Metastatic Melanoma.

Author

Weber, Jeffrey S., Samlowski, Wolfram E., Gonzalez, Rene, Ribas, Antoni, Stephenson, Joe, O'Day, Steven, Sato, Takami, Dorr, Robert, Grenierg, Kathryn, and Hersh, Evan

Subjects
MELANOMA, ANTINEOPLASTIC agents, MELANOCYTES, DRUG therapy, SKIN cancer, IMIDAZOLES, CANCER patients
Abstract

The article discusses a study on the overall toxicities and the dose limiting toxicity (DLT) of a combined imexon and dacarbazine including its maximal tolerated dose (MTD) and antitumor efficacy. Pharmacokinetic studies of the two drugs were done in the phase 2 portion of the study in selected patients aged 18 years and above with inoperable stage 3 or 4 melanoma. The study concluded that the combination of imexon and dacarzabine was tolerated well by patients with metastatic melanoma but did not produce an increased progression-free survival.

Published
2010
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