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4 results on '"Gretchen M. Larson"'

1. Macromolecular cytosolic delivery: Cell membranes as the primary obstacle

Author

Kyung Dall Lee and Gretchen M. Larson

Subjects
Cognitive science, Bacteria, Macromolecular Substances, Cell Membrane, Genetic Vectors, Organic Chemistry, Cytosolic delivery, Pharmacology toxicology, Biology, Cytosol, Drug Delivery Systems, Membrane, Obstacle, Gene Targeting, Viruses, Drug Discovery, Immunology, Humans, Molecular Medicine
Abstract

The “evolution” of a thing, a custom, an organ is thus by no means its progressus toward a goal, even less a logical progressus by the shortest route and with the least expenditure of force, but a succession of more of less profound, mutually independent processes of subduing, plus the resistances they encounter, the attempts at transformation for the purpose of defense and reaction, and the results of successful counteractions. The form is fluid, but the “meaning” is even more so (Friedrich W. Nietzsche).

Published
1998
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2. Two New Maytansinoids from Maytenus buchananii

Author

Gretchen M. Larson, Albert T. Sneden, and Brian T. Schaneberg

Subjects
Pharmacology, chemistry.chemical_classification, biology, Maytenus, Stereochemistry, Organic Chemistry, Pharmaceutical Science, Pharmacognosy, Carbon-13 NMR, Maytansinoid, biology.organism_classification, Analytical Chemistry, Celastraceae, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Drug Discovery, Proton NMR, Molecular Medicine, Organic chemistry, Two-dimensional nuclear magnetic resonance spectroscopy, Lactone
Abstract

Reinvestigation of fractions derived from large-scale fractionation of Maytenus buchananii led to the isolation of two new maytansinoids. The structures of these principles were determined using electrospray MS, 1H NMR, 13C NMR, and 2D NMR techniques. One principle was found to be 2'-N-demethylmaytanbutine (2), while the other was found to be maytanbicyclinol (3), the first maytansinoid with two macrocyclic rings to be isolated from a Maytenus species.

Published
1999
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4. Controlled Drug Delivery

Author

KINAM PARK, RANDALL J. MRSNY, Joseph A. Fix, Kazuhiro Sako, Toyohiro Sawada, H. E. Junginger, M. Thanou, H. L. Lueßen, A. F. Kotzé, J. C. Verhoef, Ronald T. Borchardt, Binghe Wang, Hyo-kyung Han, Gordon L. Amidon, Andrea Leone-Bay, Theresa Rivera-Schaub, Rajesh Agarwal, Mark Gonze, Sam Money, Connie Rosado-Gray, Robert A. Baughman, M. X. Duan, J. H. Guo, H. Ma, Y. Zuo, C. X. Zheng, Avinash G. Thombre, Abraham Rubinstein, Sigal Blau, Paul Bass, Ron Kohen, A. Ainaoui, E. M. Ouriemchi, J. M. Vergnaud, Theresa M. Allen, Wayne R. Gombotz, Dean K. Pettit, Lichun Lu, Susan J. Peter, Georgios N. Stamatas, Antonios G. Mikos, Sannamu Lee, H. Michael Ellerby, Taira Kiyota, Gohsuke Sugihara, W. I. Lencer, D. Merlin, A. J. Ouellette, M. E. Selsted, J. L. Madara, Martin C. Peters, David J. Mooney, Gilbert-André Keller, Wenlu Li, Kyung-Dall Lee, Gretchen M. Larson, Yon Rojanasakul, Q. Luo, J. Ye, D. Faroonsargn, S. Dokka, X. Shi, Mitsuru Hashida, Makiya Nishikawa, Fumiyoshi Yamashita, Yoshinobu Takakura, Wenjin Guo, Robert J. Lee, Yang Liu, Qingzhong Kong, Ka-yun Ng, Ke, KINAM PARK, RANDALL J. MRSNY, Joseph A. Fix, Kazuhiro Sako, Toyohiro Sawada, H. E. Junginger, M. Thanou, H. L. Lueßen, A. F. Kotzé, J. C. Verhoef, Ronald T. Borchardt, Binghe Wang, Hyo-kyung Han, Gordon L. Amidon, Andrea Leone-Bay, Theresa Rivera-Schaub, Rajesh Agarwal, Mark Gonze, Sam Money, Connie Rosado-Gray, Robert A. Baughman, M. X. Duan, J. H. Guo, H. Ma, Y. Zuo, C. X. Zheng, Avinash G. Thombre, Abraham Rubinstein, Sigal Blau, Paul Bass, Ron Kohen, A. Ainaoui, E. M. Ouriemchi, J. M. Vergnaud, Theresa M. Allen, Wayne R. Gombotz, Dean K. Pettit, Lichun Lu, Susan J. Peter, Georgios N. Stamatas, Antonios G. Mikos, Sannamu Lee, H. Michael Ellerby, Taira Kiyota, Gohsuke Sugihara, W. I. Lencer, D. Merlin, A. J. Ouellette, M. E. Selsted, J. L. Madara, Martin C. Peters, David J. Mooney, Gilbert-André Keller, Wenlu Li, Kyung-Dall Lee, Gretchen M. Larson, Yon Rojanasakul, Q. Luo, J. Ye, D. Faroonsargn, S. Dokka, X. Shi, Mitsuru Hashida, Makiya Nishikawa, Fumiyoshi Yamashita, Yoshinobu Takakura, Wenjin Guo, Robert J. Lee, Yang Liu, Qingzhong Kong, Ka-yun Ng, and Ke

Subjects
Therapeutics, Drugs, Drug carriers (Pharmacy), Chemotherapy, Drug delivery systems--Congresses, Drug targeting--Congresses, Drugs--Dosage forms
Published
2000

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