1. Histopathology of aortic complications in bicuspid aortic valve versus Marfan syndrome: relevance for therapy?
- Author
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Grewal, N. (Nimrat), Franken, R. (Romy), Mulder, B.J.M. (Barbara), Goumans, M.-J. (Marie-José), Lindeman, J.H.N. (Johannes), Jongbloed, M.R.M. (Monique), DeRuiter, M.C. (Marco), Klautz, R.J.M. (Robert), Bogers, A.J.J.C. (Ad), Poelmann, R.E. (Robert), Gittenberger-de Groot, A.C. (Adriana), Grewal, N. (Nimrat), Franken, R. (Romy), Mulder, B.J.M. (Barbara), Goumans, M.-J. (Marie-José), Lindeman, J.H.N. (Johannes), Jongbloed, M.R.M. (Monique), DeRuiter, M.C. (Marco), Klautz, R.J.M. (Robert), Bogers, A.J.J.C. (Ad), Poelmann, R.E. (Robert), and Gittenberger-de Groot, A.C. (Adriana)
- Abstract
Patients with bicuspid aortic valve (BAV) and patients with Marfan syndrome (MFS) are more prone to develop aortic dilation and dissection compared to persons with a tricuspid aortic valve (TAV). To elucidate potential common and distinct pathways of clinical relevance, we compared the histopathological substrates of aortopathy. Ascending aortic wall biopsies were divided in five groups: BAV (n = 36) and TAV (n = 23) without and with dilation and non-dilated MFS (n = 8). General histologic features, apoptosis, the expre
- Published
- 2016
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