Search

Your search keyword '"Grieco, Antonella"' showing total 20 results
Start Over Author "Grieco, Antonella"
20 results on '"Grieco, Antonella"'

1. Adeno‐Associated Virus Type 5 Infection via PDGFRα Is Associated With Interstitial Lung Disease in Systemic Sclerosis and Generates Composite Peptides and Epitopes Recognized by the Agonistic Immunoglobulins Present in Patients With Systemic Sclerosis

Author

Moroncini, Gianluca, primary, Svegliati, Silvia, additional, Grieco, Antonella, additional, Cuccioloni, Massimiliano, additional, Mozzicafreddo, Matteo, additional, Paolini, Chiara, additional, Agarbati, Silvia, additional, Spadoni, Tatiana, additional, Amoresano, Angela, additional, Pinto, Gabriella, additional, Chen, Qingxin, additional, Benfaremo, Devis, additional, Tonnini, Cecilia, additional, Senzacqua, Martina, additional, Alizzi, Silvia, additional, Nieto, Karen, additional, Finke, Doreen, additional, Viola, Nadia, additional, Amico, Donatella, additional, Galgani, Mario, additional, Gasparini, Stefano, additional, Zuccatosta, Lina, additional, Menzo, Stefano, additional, Müller, Martin, additional, Kleinschmidt, Jürgen, additional, Funaro, Ada, additional, Giordano, Antonio, additional, La Cava, Antonio, additional, Dorfmüller, Peter, additional, Amoroso, Antonio, additional, Pucci, Piero, additional, Pezone, Antonio, additional, Avvedimento, Enrico V., additional, and Gabrielli, Armando, additional

Published
2024
Full Text
View/download PDF

2. A Contagious... Smile! Training Emotional Skills of Adults with Intellectual Disability in the Time of COVID-19

Author

Vanutelli, M, Grieco, A, Comelli, E, Lucchiari, C, Vanutelli, Maria Elide, Grieco, Antonella, Comelli, Eleonora, Lucchiari, Claudio, Vanutelli, M, Grieco, A, Comelli, E, Lucchiari, C, Vanutelli, Maria Elide, Grieco, Antonella, Comelli, Eleonora, and Lucchiari, Claudio

Abstract

The COVID-19 emergency has had important implications not only for physical but also for psychological well-being. This is particularly true for fragile populations such as people with intellectual disability (ID), who are particularly at risk of suffering during uncertain times. The goal of this action research was to design, implement, and test the efficacy of emotional competencies training to support people with ID in coping with stressful events. For this purpose, eight adults with ID followed a 5-week training of increasing complexity, aimed at exercising different skills through group activities. We designed a study to test its feasibility and efficacy, using both quantitative and qualitative methods. The analyses revealed that, after the training, participants used a more complex emotional language and were able to frame their perception of COVID-related threat with greater confidence and awareness. These findings, although circumscribed, respond positively to the urgent need to develop emotional support programs targeted at people with ID.

Published
2023

4. Trans-spliced peptides spanning PDGFRα and Adeno-Associated Virus type 5 trigger autoimmune responses in systemic sclerosis patients

Author

Gabrielli, Armando, primary, Moroncini, Gianluca, additional, Svegliati, Silvia, additional, Grieco, Antonella, additional, Cuccioloni, Massimiliano, additional, Mozzicafreddo, Matteo, additional, Paolini, Chiara, additional, Agarbati, Silvia, additional, Spadoni, Tatiana, additional, Amoresano, Angela, additional, Pinto, Gabriella, additional, Chen, Qingxin, additional, Benfaremo, Devis, additional, Tonnini, Cecilia, additional, Senzacqua, Martina, additional, Alizzi, Silvia, additional, Nieto, Karen, additional, Finke, Doreen, additional, Viola, Nadia, additional, Amico, Donatella, additional, Galgani, Mario, additional, Gasparini, Stefano, additional, Menzo, Stefano, additional, Müller, Martin, additional, Kleinschmidt, Juergen, additional, Funaro, Ada, additional, Giordano, Antonio, additional, Cava, Antonio La, additional, Dorfmuller, Peter, additional, Amoroso, Antonio, additional, Pucci, Piero, additional, and Avvedimento, Enrico, additional

Published
2022
Full Text
View/download PDF

9. Induction of Scleroderma Fibrosis in Skin-Humanized Mice by Administration of Anti−Platelet-Derived Growth Factor Receptor Agonistic Autoantibodies

Author

Luchetti, Michele M, Moroncini, Gianluca, Jose Escamez, Maria, Svegliati Baroni, Silvia, Spadoni, Tatiana, Grieco, Antonella, Paolini, Chiara, Funaro, Ada, AVVEDIMENTO, VITTORIO ENRICO, Larcher, Fernando, Del Rio, Marcela, Gabrielli, Armando, Luchetti, Michele M, Moroncini, Gianluca, Jose Escamez, Maria, Svegliati Baroni, Silvia, Spadoni, Tatiana, Grieco, Antonella, Paolini, Chiara, Funaro, Ada, Avvedimento, VITTORIO ENRICO, Larcher, Fernando, Del Rio, Marcela, and Gabrielli, Armando

Subjects
Rheumatology, Immunology, Immunology and Allergy
Abstract

To describe a skin-SCID mouse chimeric model of systemic sclerosis (SSc; scleroderma) fibrosis based on engraftment of ex vivo-bioengineered skin using skin cells derived either from scleroderma patients or from healthy donors.

Published
2016

10. Mesenchymal stromal cells from human umbilical cord prevent the development of lung fibrosis in immunocompetent mice

Author

Moroncini, Gianluca, primary, Paolini, Chiara, additional, Orlando, Fiorenza, additional, Capelli, Chiara, additional, Grieco, Antonella, additional, Tonnini, Cecilia, additional, Agarbati, Silvia, additional, Mondini, Eleonora, additional, Saccomanno, Stefania, additional, Goteri, Gaia, additional, Svegliati Baroni, Silvia, additional, Provinciali, Mauro, additional, Introna, Martino, additional, Del Papa, Nicoletta, additional, and Gabrielli, Armando, additional

Published
2018
Full Text
View/download PDF

11. Characterization of binding and quantification of human autoantibodies to PDGFRα using a biosensor-based approach

Author

Moroncini, Gianluca, primary, Cuccioloni, Massimiliano, additional, Mozzicafreddo, Matteo, additional, Pozniak, Katarzyna Natalia, additional, Grieco, Antonella, additional, Paolini, Chiara, additional, Tonnini, Cecilia, additional, Spadoni, Tatiana, additional, Svegliati, Silvia, additional, Funaro, Ada, additional, Angeletti, Mauro, additional, and Gabrielli, Armando, additional

Published
2017
Full Text
View/download PDF

12. Corrigendum: Agonistic Anti-PDGF Receptor Autoantibodies from Patients with Systemic Sclerosis Impact Human Pulmonary Artery Smooth Muscle Cells Function In Vitro

Author

Svegliati, Silvia, primary, Amico, Donatella, additional, Spadoni, Tatiana, additional, Fischetti, Colomba, additional, Finke, Doreen, additional, Moroncini, Gianluca, additional, Paolini, Chiara, additional, Tonnini, Cecilia, additional, Grieco, Antonella, additional, Rovinelli, Marina, additional, Funaro, Ada, additional, and Gabrielli, Armando, additional

Published
2017
Full Text
View/download PDF

13. Agonistic Anti-PDGF Receptor Autoantibodies from Patients with Systemic Sclerosis Impact Human Pulmonary Artery Smooth Muscle Cells Function In Vitro

Author

Svegliati, Silvia, primary, Amico, Donatella, additional, Spadoni, Tatiana, additional, Fischetti, Colomba, additional, Finke, Doreen, additional, Moroncini, Gianluca, additional, Paolini, Chiara, additional, Tonnini, Cecilia, additional, Grieco, Antonella, additional, Rovinelli, Marina, additional, and Gabrielli, Armando, additional

Published
2017
Full Text
View/download PDF

14. Induction of Scleroderma Fibrosis in Skin-Humanized Mice by Administration of Anti−Platelet-Derived Growth Factor Receptor Agonistic Autoantibodies

Author

Luchetti, Michele M., primary, Moroncini, Gianluca, additional, Jose Escamez, Maria, additional, Svegliati Baroni, Silvia, additional, Spadoni, Tatiana, additional, Grieco, Antonella, additional, Paolini, Chiara, additional, Funaro, Ada, additional, Avvedimento, Enrico V., additional, Larcher, Fernando, additional, Del Rio, Marcela, additional, and Gabrielli, Armando, additional

Published
2016
Full Text
View/download PDF

15. Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis

Author

Svegliati, Silvia, primary, Marrone, Giusi, additional, Pezone, Antonio, additional, Spadoni, Tatiana, additional, Grieco, Antonella, additional, Moroncini, Gianluca, additional, Grieco, Domenico, additional, Vinciguerra, Maria, additional, Agnese, Savina, additional, Jüngel, Astrid, additional, Distler, Oliver, additional, Musti, Anna Maria, additional, Gabrielli, Armando, additional, and Avvedimento, Enrico V., additional

Published
2014
Full Text
View/download PDF

16. Mapping B-cell epitopes of hepatitis C virus E2 glycoprotein using human monoclonal antibodies from phage display libraries

Author

Bugli, Francesca, Mancini, N, Kang, Cy, Di Campli, Cristiana, Grieco, Antonella, Manzin, A, Gabrielli, Armando, Gasbarrini, Antonio, Fadda, Guido, Varaldo, Pe, Clementi, Maria Elisabetta, Burioni, R, Bugli, Francesca (ORCID:0000-0001-9038-3233), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Fadda, Guido (ORCID:0000-0003-2013-7293), Bugli, Francesca, Mancini, N, Kang, Cy, Di Campli, Cristiana, Grieco, Antonella, Manzin, A, Gabrielli, Armando, Gasbarrini, Antonio, Fadda, Guido, Varaldo, Pe, Clementi, Maria Elisabetta, Burioni, R, Bugli, Francesca (ORCID:0000-0001-9038-3233), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), and Fadda, Guido (ORCID:0000-0003-2013-7293)

Abstract

Clinical and experimental evidence indicates that the hepatitis C virus (HCV) E2 glycoprotein (HCV/E2) is the most promising candidate for the development of an effective anti-HCV vaccine. Identification of the human epitopes that are conserved among isolates and are able to elicit protective antibodies would constitute a significant step forward. This work describes the mapping of the B-cell epitopes present on the surface of HCV/E2, as recognized by the immune system during infection, by the analysis of the reciprocal interactions of a panel of human recombinant Fabs derived from an HCV-infected patient. Three unrelated epitopes recognized by antibodies with no neutralization-of-binding (NOB) activity were identified; a fourth, major epitope was defined as a clustering of minor epitopes recognized by Fabs endowed with strong NOB activity.

Published
2001

18. Mapping B-Cell Epitopes of Hepatitis C Virus E2 Glycoprotein Using Human Monoclonal Antibodies from Phage Display Libraries

Author

Bugli, Francesca, primary, Mancini, Nicasio, additional, Kang, Chang-Yuil, additional, Di Campli, Cristiana, additional, Grieco, Antonella, additional, Manzin, Aldo, additional, Gabrielli, Armando, additional, Gasbarrini, Antonio, additional, Fadda, Giovanni, additional, Varaldo, Pietro E., additional, Clementi, Massimo, additional, and Burioni, Roberto, additional

Published
2001
Full Text
View/download PDF

19. Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis

Author

Astrid Jüngel, Giusi Marrone, Gianluca Moroncini, Antonio Pezone, Silvia Svegliati, Maria Vinciguerra, Savina Agnese, Tatiana Spadoni, Enrico V. Avvedimento, Oliver Distler, Domenico Grieco, Armando Gabrielli, A. Grieco, Anna Maria Musti, Svegliati, Silvia, Marrone, Giusi, Pezone, Antonio, Spadoni, Tatiana, Grieco, Antonella, Moroncini, Gianluca, Grieco, Domenico, Vinciguerra, Maria, Agnese, Savina, Jüngel, Astrid, Distler, Oliver, Musti, Anna Maria, Gabrielli, Armando, Avvedimento, VITTORIO ENRICO, and University of Zurich

Subjects
1303 Biochemistry, Fibrosi, Biopsy, Wnt Protein, Ataxia Telangiectasia Mutated Proteins, Hydroxamic Acids, medicine.disease_cause, Biochemistry, Hydroxamic Acid, 1307 Cell Biology, Ataxia Telangiectasia Mutated Protein, Fibrosis, Ultraviolet light, Protein Synthesis Inhibitors, Antibiotics, Antineoplastic, 10051 Rheumatology Clinic and Institute of Physical Medicine, Wnt signaling pathway, Fibroblast, Protein Synthesis Inhibitor, Reactive Oxygen Specie, medicine.drug, Human, Signal Transduction, DNA damage, 610 Medicine & health, Biology, Collagen Type I, Bleomycin, 1312 Molecular Biology, medicine, Humans, Gene silencing, Gene Silencing, Molecular Biology, Adaptor Proteins, Signal Transducing, Scleroderma, Systemic, Cell Biology, Fibroblasts, G2-M DNA damage checkpoint, DNA Methylation, Repressor Protein, medicine.disease, Collagen Type I, alpha 1 Chain, Repressor Proteins, Wnt Proteins, Oxygen, Oxidative Stress, Trichostatin A, Immunoglobulin G, Cancer research, Reactive Oxygen Species, Oxidative stress, DNA Damage
Abstract

Systemic sclerosis (SSc) is an autoimmune disease characterized by extensive visceral organ and skin fibrosis. SSc patients have increased production of autoreactive antibodies and Wnt signaling activity. We found that expression of the gene encoding Wnt inhibitor factor 1 (WIF-1) was decreased in fibroblasts from SSc patient biopsies. WIF-1 deficiency in SSc patient cells correlated with increased abundance of the Wnt effector β-catenin and the production of collagen. Knocking down WIF-1 in normal fibroblasts increased Wnt signaling and collagen production. WIF-1 loss and DNA damage were induced in normal fibroblasts by either SSc patient immunoglobulins or oxidative DNA-damaging agents, such as ultraviolet light, hydrogen peroxide, or bleomycin. The DNA damage checkpoint kinase ataxia telangiectasia mutated (ATM) mediated WIF-1 silencing through the phosphorylation of the transcription factor c-Jun, which in turn activated the expression of the gene encoding activating transcription factor 3 (ATF3). ATF3 and c-Jun were recruited together with histone deacetylase 3 (HDAC3) to the WIF-1 promoter and inhibited WIF-1 expression. Preventing the accumulation of reactive oxygen species or inhibiting the activation of ATM, c-Jun, or HDACs restored WIF-1 expression in cultured SSc patient cells. Trichostatin A, an HDAC inhibitor, prevented WIF-1 loss, β-catenin induction, and collagen accumulation in an experimental fibrosis model. Our findings suggest that oxidative DNA damage induced by SSc autoreactive antibodies enables Wnt activation that contributes to fibrosis.

Published
2014

20. Induction of Scleroderma Fibrosis in Skin-Humanized Mice by Administration of Anti-Platelet-Derived Growth Factor Receptor Agonistic Autoantibodies.

Author

Luchetti MM, Moroncini G, Jose Escamez M, Svegliati Baroni S, Spadoni T, Grieco A, Paolini C, Funaro A, Avvedimento EV, Larcher F, Del Rio M, and Gabrielli A

Subjects
Animals, Fibrosis immunology, Mice, Mice, SCID, Scleroderma, Localized pathology, Scleroderma, Systemic pathology, Skin immunology, Autoantibodies administration & dosage, Disease Models, Animal, Receptors, Platelet-Derived Growth Factor immunology, Scleroderma, Localized immunology, Scleroderma, Systemic immunology
Abstract

Objective: To describe a skin-SCID mouse chimeric model of systemic sclerosis (SSc; scleroderma) fibrosis based on engraftment of ex vivo-bioengineered skin using skin cells derived either from scleroderma patients or from healthy donors., Methods: Three-dimensional bioengineered skin containing human keratinocytes and fibroblasts isolated from skin biopsy specimens from healthy donors or SSc patients was generated ex vivo and then grafted onto the backs of SCID mice. The features of the skin grafts were analyzed by immunohistochemistry, and the functional profile of the graft fibroblasts was defined before and after treatment with IgG from healthy controls or SSc patients. Two procedures were used to investigate the involvement of platelet-derived growth factor receptor (PDGFR): 1) nilotinib, a tyrosine kinase inhibitor, was administered to mice before injection of IgG from SSc patient sera (SSc IgG) into the grafts, and 2) human anti-PDGFR monoclonal antibodies were injected into the grafts., Results: Depending on the type of bioengineered skin grafted, the regenerated human skin exhibited either the typical scleroderma phenotype or the healthy human skin architecture. Treatment of animals carrying healthy donor skin grafts with SSc IgG resulted in the appearance of a bona fide scleroderma phenotype, as confirmed by increased collagen deposition and fibroblast activation markers. Results of the experiments involving administration of nilotinib or monoclonal antibodies confirmed the involvement of PDGFR., Conclusion: Our results provide the first in vivo demonstration of the fibrotic properties of anti-PDGFR agonistic antibodies. This bioengineered skin-humanized mouse model can be used to test in vivo the progression of the disease and to monitor response to antifibrotic drugs., (© 2016, American College of Rheumatology.)

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results