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7. The inflammatory potential of diet is associated with future development of pre-clinical carotid atherosclerosis

Author

Mattavelli, E., primary, Piperni, E., additional, Nabinejad, A., additional, Redaelli, L., additional, Grigore, L., additional, Pellegatta, F., additional, Magni, P., additional, Tamburini, S., additional, Asnicar, F., additional, Segata, N., additional, De Gaetano, L. Nicolini, additional, Catapano, A., additional, and Baragetti, A., additional

Published
2023
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12. The Role of Registers in Increasing Knowledge and Improving Management of Children and Adolescents Affected by Familial Hypercholesterolemia: the LIPIGEN Pediatric Group

Author

Gazzotti, M, Casula, M, Bertolini, S, Capra, M, Olmastroni, E, Catapano, A, Pederiva, C, Allevi, M, Arca, M, Auricchio, R, Averna, M, Baldera, D, Banderali, G, Bartuli, A, Biasucci, G, Borghi, C, Bruzzi, P, Buganza, R, Buonuomo, P, Calabro, P, Calandra, S, Carubbi, F, Cesaro, A, Cipollone, F, Citroni, N, Covetti, G, Cremonini, A, D'Addato, S, Ben, M, Di Taranto, M, Fortunato, G, Franceschi, R, Galimberti, F, Genovesi, S, Giammanco, A, Grigore, L, Guardamagna, O, Iannuzzi, A, Iannuzzo, G, Lascala, L, Locatelli, F, Iughetti, L, Madaghiele, S, Mandraffino, G, Mannarino, M, Marco, B, Maroni, L, Minicocci, I, Mombelli, G, Muntoni, S, Nascimbeni, F, Parati, G, Passaro, A, Pavanello, C, Pellegatta, F, Perla, F, Generale, M, Pirro, M, Pisciotta, L, Pujia, A, Purrello, F, Rinaldi, E, Sarzani, R, Scicali, R, Suppressa, P, Tarugi, P, Verachtert, S, Vigna, G, Werba, J, Zambon, A, Zambon, S, Zenti, M, Gazzotti M., Casula M., Bertolini S., Capra M. E., Olmastroni E., Catapano A. L., Pederiva C., Allevi M., Arca M., Auricchio R., Averna M., Baldera D., Banderali G., Bartuli A., Biasucci G., Borghi C., Bruzzi P., Buganza R., Buonuomo P. S., Calabro P., Calandra S., Carubbi F., Cesaro A., Cipollone F., Citroni N., Covetti G., Cremonini A., D'Addato S., Ben M. D., Di Taranto M. D., Fortunato G., Franceschi R., Galimberti F., Genovesi S., Giammanco A., Grigore L., Guardamagna O., Iannuzzi A., Iannuzzo G., Lascala L., Locatelli F., Iughetti L., Madaghiele S., Mandraffino G., Mannarino M. R., Marco B., Maroni L., Minicocci I., Mombelli G., Muntoni S., Nascimbeni F., Parati G., Passaro A., Pavanello C., Pellegatta F., Perla F. M., Generale M., Pirro M., Pisciotta L., Pujia A., Purrello F., Rinaldi E., Sarzani R., Scicali R., Suppressa P., Tarugi P., Verachtert S., Vigna G. B., Werba J. P., Zambon A., Zambon S., Zenti M. G., Gazzotti, M, Casula, M, Bertolini, S, Capra, M, Olmastroni, E, Catapano, A, Pederiva, C, Allevi, M, Arca, M, Auricchio, R, Averna, M, Baldera, D, Banderali, G, Bartuli, A, Biasucci, G, Borghi, C, Bruzzi, P, Buganza, R, Buonuomo, P, Calabro, P, Calandra, S, Carubbi, F, Cesaro, A, Cipollone, F, Citroni, N, Covetti, G, Cremonini, A, D'Addato, S, Ben, M, Di Taranto, M, Fortunato, G, Franceschi, R, Galimberti, F, Genovesi, S, Giammanco, A, Grigore, L, Guardamagna, O, Iannuzzi, A, Iannuzzo, G, Lascala, L, Locatelli, F, Iughetti, L, Madaghiele, S, Mandraffino, G, Mannarino, M, Marco, B, Maroni, L, Minicocci, I, Mombelli, G, Muntoni, S, Nascimbeni, F, Parati, G, Passaro, A, Pavanello, C, Pellegatta, F, Perla, F, Generale, M, Pirro, M, Pisciotta, L, Pujia, A, Purrello, F, Rinaldi, E, Sarzani, R, Scicali, R, Suppressa, P, Tarugi, P, Verachtert, S, Vigna, G, Werba, J, Zambon, A, Zambon, S, Zenti, M, Gazzotti M., Casula M., Bertolini S., Capra M. E., Olmastroni E., Catapano A. L., Pederiva C., Allevi M., Arca M., Auricchio R., Averna M., Baldera D., Banderali G., Bartuli A., Biasucci G., Borghi C., Bruzzi P., Buganza R., Buonuomo P. S., Calabro P., Calandra S., Carubbi F., Cesaro A., Cipollone F., Citroni N., Covetti G., Cremonini A., D'Addato S., Ben M. D., Di Taranto M. D., Fortunato G., Franceschi R., Galimberti F., Genovesi S., Giammanco A., Grigore L., Guardamagna O., Iannuzzi A., Iannuzzo G., Lascala L., Locatelli F., Iughetti L., Madaghiele S., Mandraffino G., Mannarino M. R., Marco B., Maroni L., Minicocci I., Mombelli G., Muntoni S., Nascimbeni F., Parati G., Passaro A., Pavanello C., Pellegatta F., Perla F. M., Generale M., Pirro M., Pisciotta L., Pujia A., Purrello F., Rinaldi E., Sarzani R., Scicali R., Suppressa P., Tarugi P., Verachtert S., Vigna G. B., Werba J. P., Zambon A., Zambon S., and Zenti M. G.

Abstract

Pathology registers can be a useful tool to overcome obstacles in the identification and management of familial hypercholesterolemia since childhood. In 2018, the LIPIGEN pediatric group was constituted within the Italian LIPIGEN study to focus on FH subjects under 18 years. This work aimed at discussing its recent progress and early outcomes. Demographic, biochemical, and genetic baseline characteristics were collected, with an in-depth analysis of the genetic defects. The analysis was carried out on 1,602 children and adolescents (mean age at baseline 9.9 ± 4.0 years), and almost the whole cohort underwent the genetic test (93.3%). Overall, the untreated mean value of LDL-C was 220.0 ± 97.2 mg/dl, with an increasing gradient from subjects with a negative (N = 317; mean untreated LDL-C = 159.9 ± 47.7 mg/dl), inconclusive (N = 125; mean untreated LDL-C = 166.4 ± 56.5 mg/dl), or positive (N = 1,053; mean untreated LDL-C = 246.5 ± 102.1 mg/dl) genetic diagnosis of FH. In the latter group, the LDL-C values presented a great variability based on the number and the biological impact of involved causative variants. The LIPIGEN pediatric group represents one of the largest cohorts of children with FH, allowing the deepening of the characterization of their baseline and genetic features, providing the basis for further longitudinal investigations for complete details.

Published
2022

14. Reported muscle symptoms during statin treatment amongst Italian dyslipidaemic patients in the real‐life setting: the PROSISA Study

Author

Casula, M., Gazzotti, M., Bonaiti, F., Oimastroni, E., Arca, M., Averna, M., Zambon, A., Catapano, A. L., Montali, A., Giammanco, A., Biolo, G., Vinci, P., Borghi, C., D'Addato, S., Bossi, A. C., Meregalli, G., Branchi, A., Squiccimarro, G., Cavalot, F., Ramadori, L., Cipollone, F., Bucci, M., Del Ben, M., Angelico, F., Fiorenza, A. M., Colombo, E., Grigore, L., Zampoleri, V., Lupattelli, G., Gandolfo, V., Mandraffino, G., Savarino, F., Mombelli, G., Pavanello, C., Pisciotta, L., Pasta, A., Purrello, F., Scicali, R., Rubba, P., Fortunato, G., Sabba, C., Suppressa, P., Sarzani, R., Di Pentima, C., Vigna, G. B., Colangiulo, A., Werba, J. P., Vigo, L. M., Zambon, S., Previato, L., Zenti, M. G., Maneschi, C., Casula, M., Gazzotti, M., Bonaiti, F., Oimastroni, E., Arca, M., Averna, M., Zambon, A., Catapano, A. L., Montali, A., Giammanco, A., Biolo, G., Vinci, P., Borghi, C., D'Addato, S., Bossi, A. C., Meregalli, G., Branchi, A., Squiccimarro, G., Cavalot, F., Ramadori, L., Cipollone, F., Bucci, M., Del Ben, M., Angelico, F., Fiorenza, A. M., Colombo, E., Grigore, L., Zampoleri, V., Lupattelli, G., Gandolfo, V., Mandraffino, G., Savarino, F., Mombelli, G., Pavanello, C., Pisciotta, L., Pasta, A., Purrello, F., Scicali, R., Rubba, P., Fortunato, G., Sabba, C., Suppressa, P., Sarzani, R., Di Pentima, C., Vigna, G. B., Colangiulo, A., Werba, J. P., Vigo, L. M., Zambon, S., Previato, L., Zenti, M. G., Maneschi, C., Casula M, Gazzotti M, Bonaiti F, OImastroni E, Arca M, Averna M, Zambon A, Catapano AL, PROSISA Study Group, Borghi C, Casula M., Gazzotti M., Bonaiti F., OImastroni E., Arca M., Averna M., Zambon A., Catapano A.L., Montali A., Giammanco A., Biolo G., Vinci P., Borghi C., D'Addato S., Bossi A.C., Meregalli G., Branchi A., Squiccimarro G., Cavalot F., Ramadori L., Cipollone F., Bucci M., Del Ben M., Angelico F., Fiorenza A.M., Colombo E., Grigore L., Zampoleri V., Lupattelli G., Gandolfo V., Mandraffino G., Savarino F., Mombelli G., Pavanello C., Pisciotta L., Pasta A., Purrello F., Scicali R., Rubba P., Fortunato G., Sabba C., Suppressa P., Sarzani R., Di Pentima C., Vigna G.B., Colangiulo A., Werba J.P., Vigo L.M., Zambon S., Previato L., Zenti M.G., and Maneschi C.

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Settore MED/09 - Medicina Interna, adverse effects, myopathy, statin-associated muscle symptoms, statins, 030204 cardiovascular system & hematology, Medication Adherence, 03 medical and health sciences, 0302 clinical medicine, Muscular Diseases, Internal medicine, adverse effect, Internal Medicine, medicine, Prevalence, Humans, statin‐associated muscle symptoms, Adverse effect, Dechallenge, Creatine Kinase, Dyslipidemias, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Italy, Middle Aged, Retrospective Studies, business.industry, Retrospective cohort study, Odds ratio, Original Articles, Confidence interval, Discontinuation, 030104 developmental biology, Concomitant, Cohort, Original Article, business, statin-associated muscle symptom
Abstract

Aim: Statin-associated muscle symptoms (SAMS) are a major determinant of poor treatment adherence and/or discontinuation, but a definitive diagnosis of SAMS is challenging. The PROSISA study was an observational retrospective study aimed to assess the prevalence of reported SAMS in a cohort of dyslipidaemic patients. Methods: Demographic/anamnestic data, biochemical values and occurrence of SAMS were collected by 23 Italian Lipid Clinics. Adjusted logistic regression was performed to estimate odds ratio (OR) and 95% confidence intervals for association between probability of reporting SAMS and several factors. Results: Analyses were carried out on 16717 statin-treated patients (mean±SD, age 60.5±12.0years; 52.1% men). During statin therapy, 9.6% (N=1599) of patients reported SAMS. Women and physically active subjects were more likely to report SAMS (OR 1.23 [1.10–1.37] and OR 1.35 [1.14–1.60], respectively), whist age≥65 (OR 0.79 [0.70–0.89]), presence of type 2 diabetes mellitus (OR 0.62 [0.51–0.74]), use of concomitant nonstatin lipid-lowering drugs (OR 0.87 [0.76–0.99]), use of high-intensity statins (OR 0.79 [0.69–0.90]) and use of potential interacting drugs (OR 0.63 [0.48–0.84]) were associated with lower probability of reporting SAMS. Amongst patients reporting SAMS, 82.2% underwent dechallenge (treatment interruption) and/or rechallenge (change or restart of statin therapy), with reappearance of muscular symptoms in 38.4% (3.01% of the whole cohort). Conclusions: The reported prevalence of SAMS was 9.6% of the whole PROSISA cohort, but only a third of patients still reported SAMS after dechallenge/rechallenge. These results emphasize the need for a better management of SAMS to implement a more accurate diagnosis and treatment re-evaluation.

Published
2020

25. Individual diet relates to gut microbiota functional dysbiosis since subclinical stages of atherosclerosis

Author

Baragetti, A., primary, Severgnini, M., additional, Olmastroni, E., additional, Dioguardi, C. Conca, additional, Mattavelli, E., additional, Angius, A., additional, Rotta, L., additional, Cibella, J., additional, Consolandi, C., additional, Grigore, L., additional, Pellegatta, F., additional, Giavarini, F., additional, Caruso, D., additional, Norata, D.G., additional, Catapano, A.L., additional, and Peano, C., additional

Published
2021
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30. Free Communications 5: Epidemiology, genetics, outcomes Inflammatory markers and extent and progression of early atherosclerosis: Pooled analysis of individual participant data from 20 prospective studies of the PROG-IMT collaboration: WSC-1521

Author

Willeit, P, Thompson, S G, Agewall, S, Bergström, G, Bickel, H, Catapano, A L, Chien, K L, de Groot, E, Empana, J P, Etgen, T, Franco, O H, Iglseder, B, Johnsen, S H, Kavousi, M, Lind, L, Liu, J, Mathiesen, E B, Norata, G D, Olsen, M H, Papagianni, A, Poppert, H, Price, J F, Sacco, R L, Yanez, D N, Zhao, D, Schminke, U, Bülbül, A, Polak, J F, Sitzer, M, Hofman, A, Grigore, L, Dörr, M, Su, T C, Ducimetière, P, Xie, W, Ronkainen, K, Kiechl, S, Rundek, T, Robertson, C, Fagerberg, B, Bokemark, L, Steinmetz, H, Ikram, M A, Völzke, H, Lin, H J, Plichart, M, Tuomainen, T P, Desvarieux, M, McLachlan, S, Schmidt, C, Kauhanen, J, Willeit, J, Lorenz, M W, and Sander, D

Published
2014

31. Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium

Author

Bahls, M, Lorenz, MW, Dörr, M, Gao, L, Kitagawa, K, Tuomainen, TP, Agewall, S, Berenson, G, Catapano, AL, Norata, GD, Bots, ML, van Gilst, W, Asselbergs, FW, Brouwers, F, Uthoff, H, Sander, D, Poppert, H, Olsen, M H, Empana, JP, Schminke, U, Baldassarre, D, Veglia, F, Franco Duran, OH, Kavousi, Maryam, de Groot, E, Mathiesen, EB, Grigore, L, Polak, JF, Rundek, T, Stehouwer, CDA, Skilton, M, Hatzitolios, AI, Savopoulos, C, Ntaios, G, Plichart, M, McLachlan, S, Lind, L, Willeit, P, Steinmetz, H, Desvarieux, M, Ikram, Arfan, Johnsen, SH, Schmidt, C, Willeit, J, Ducimetiere, P, Price, JF, Bergström, G, Kauhanen, J, Kiechl, S, Sitzer, M, Bickel, H, Sacco, RL, Hofman, Bert, Völzke, H, Thompson, SG, Bahls, M, Lorenz, MW, Dörr, M, Gao, L, Kitagawa, K, Tuomainen, TP, Agewall, S, Berenson, G, Catapano, AL, Norata, GD, Bots, ML, van Gilst, W, Asselbergs, FW, Brouwers, F, Uthoff, H, Sander, D, Poppert, H, Olsen, M H, Empana, JP, Schminke, U, Baldassarre, D, Veglia, F, Franco Duran, OH, Kavousi, Maryam, de Groot, E, Mathiesen, EB, Grigore, L, Polak, JF, Rundek, T, Stehouwer, CDA, Skilton, M, Hatzitolios, AI, Savopoulos, C, Ntaios, G, Plichart, M, McLachlan, S, Lind, L, Willeit, P, Steinmetz, H, Desvarieux, M, Ikram, Arfan, Johnsen, SH, Schmidt, C, Willeit, J, Ducimetiere, P, Price, JF, Bergström, G, Kauhanen, J, Kiechl, S, Sitzer, M, Bickel, H, Sacco, RL, Hofman, Bert, Völzke, H, and Thompson, SG

Published
2020

36. LIPA gene mutations affect the composition of lipoproteins: Enrichment in ACAT-derived cholesteryl esters

Author

Gomaraschi, M., primary, Arnaboldi, L., additional, Ossoli, A., additional, Giorgio, E., additional, Pisciotta, L., additional, Lucchi, T., additional, Grigore, L., additional, Pavanello, C., additional, Granata, A., additional, Pasta, A., additional, Arosio, B., additional, Azzolino, D., additional, Baragetti, A., additional, Corsini, A., additional, Catapano, A.L., additional, and Calabresi, L., additional

Published
2020
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39. Correction: Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration (PLoS One (2018) 13:4 (e0191172) DOI: 10.1371/journal.pone.0191172)

Author

Lorenz M. W., Gao L., Ziegelbauer K., Norata G. D., Empana J. P., Schmidtmann I., Lin H. -J., McLachlan S., Bokemark L., Ronkainen K., Amato M., Schminke U., Srinivasan S. R., Lind L., Okazaki S., Stehouwer C. D. A., Willeit P., Polak J. F., Steinmetz H., Sander D., Poppert H., Desvarieux M., Arfan Ikram M., Johnsen S. H., Staub D., Sirtori C. R., Iglseder B., Beloqui O., Engstrom G., Friera A., Rozza F., Xie W., Parraga G., Grigore L., Plichart M., Blankenberg S., Su T. -C., Schmidt C., Tuomainen T. -P., Veglia F., Volzke H., Nijpels G., Willeit J., Sacco R. L., Franco O. H., Uthoff H., Hedblad B., Suarez C., Izzo R., Zhao D., Wannarong T., Catapano A., Ducimetiere P., Espinola-Klein C., Chien K. -L., Price J. F., Bergstrom G., Kauhanen J., Tremoli E., Dorr M., Berenson G., Kitagawa K., Dekker J. M., Kiechl S., Sitzer M., Bickel H., Rundek T., Hofman A., Mathiesen E. B., Castelnuovo S., Landecho M. F., Rosvall M., Gabriel R., De Luca N., Liu J., Baldassarre D., Kavousi M., De Groot E., Bots M. L., Yanez D. N., Thompson S. G., Lorenz, M. W., Gao, L., Ziegelbauer, K., Norata, G. D., Empana, J. P., Schmidtmann, I., Lin, H. -J., Mclachlan, S., Bokemark, L., Ronkainen, K., Amato, M., Schminke, U., Srinivasan, S. R., Lind, L., Okazaki, S., Stehouwer, C. D. A., Willeit, P., Polak, J. F., Steinmetz, H., Sander, D., Poppert, H., Desvarieux, M., Arfan Ikram, M., Johnsen, S. H., Staub, D., Sirtori, C. R., Iglseder, B., Beloqui, O., Engstrom, G., Friera, A., Rozza, F., Xie, W., Parraga, G., Grigore, L., Plichart, M., Blankenberg, S., Su, T. -C., Schmidt, C., Tuomainen, T. -P., Veglia, F., Volzke, H., Nijpels, G., Willeit, J., Sacco, R. L., Franco, O. H., Uthoff, H., Hedblad, B., Suarez, C., Izzo, R., Zhao, D., Wannarong, T., Catapano, A., Ducimetiere, P., Espinola-Klein, C., Chien, K. -L., Price, J. F., Bergstrom, G., Kauhanen, J., Tremoli, E., Dorr, M., Berenson, G., Kitagawa, K., Dekker, J. M., Kiechl, S., Sitzer, M., Bickel, H., Rundek, T., Hofman, A., Mathiesen, E. B., Castelnuovo, S., Landecho, M. F., Rosvall, M., Gabriel, R., De Luca, N., Liu, J., Baldassarre, D., Kavousi, M., De Groot, E., Bots, M. L., Yanez, D. N., and Thompson, S. G.

Abstract

An affiliation for Moise Desvarieux is missing. In addition to affiliation #22, Moise Desvarieux is affiliated with: METHODS Core, Centre de Recherche Epidémiologie et Statistique Paris Sorbonne Cité (CRESS), Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1153, Paris France.

Published
2018

42. Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium

Author

Bahls, M. (Martin), Lorenz, M.W. (Matthias W.), Dörr, M. (Marcus), Gao, L. (Lu), Kitagawa, K. (Kazuo), Tuomainen, T.-P. (Tomi-Pekka), Agewall, S. (Stefan), Berenson, G. (Gerald), Catapano, A.L. (Alberico), Norata, G.D. (Giuseppe), Bots, M.L. (Michiel), Gilst, W.H. (Wiek) van, Asselbergs, F.W. (Folkert), Brouwers, F.P. (Frank P), Uthoff, H. (Heiko), Sander, D. (Dirk), Poppert, H. (Holger), Hecht Olsen, M. (Michael), Empana, J.P. (Jean Philippe), Schminke, U. (Ulf), Baldassarre, D. (Damiano), Veglia, F. (Fabrizio), Franco, O.H. (Oscar), Kavousi, M. (Maryam), Groot, E. (Eric) de, Mathiesen, E.B. (Ellisiv), Grigore, L. (Liliana), Polak, J. (Joseph), Rundek, T. (Tatjana), Stehouwer, C.D. (Coen), Skilton, M.R. (Michael R), Hatzitolios, A.I. (Apostolos I), Savopoulos, C. (Christos), Ntaios, G. (George), Plichart, M. (Matthieu), McLachlan, S. (Stela), Kao, W.H.L. (Wen), Willeit, P. (Peter), Steinmetz, H. (Helmuth), Desvarieux, M. (Moise), Ikram, M.A. (Arfan), Johnsen, S.H., Schmidt, C. (Caroline), Willeit, J. (Johann), Ducimetiere, P. (P.), Price, J.F. (Jackie F), Bergström, G. (Göran), Kauhanen, J. (Jussi), Kiechl, S. (Stefan), Sitzer, M. (Matthias), Bickel, H. (Horst), Muir, K.W. (Keith), Hofman, A. (Albert), Völzke, H. (Henry), Thompson, S.G. (Simon G), Bahls, M. (Martin), Lorenz, M.W. (Matthias W.), Dörr, M. (Marcus), Gao, L. (Lu), Kitagawa, K. (Kazuo), Tuomainen, T.-P. (Tomi-Pekka), Agewall, S. (Stefan), Berenson, G. (Gerald), Catapano, A.L. (Alberico), Norata, G.D. (Giuseppe), Bots, M.L. (Michiel), Gilst, W.H. (Wiek) van, Asselbergs, F.W. (Folkert), Brouwers, F.P. (Frank P), Uthoff, H. (Heiko), Sander, D. (Dirk), Poppert, H. (Holger), Hecht Olsen, M. (Michael), Empana, J.P. (Jean Philippe), Schminke, U. (Ulf), Baldassarre, D. (Damiano), Veglia, F. (Fabrizio), Franco, O.H. (Oscar), Kavousi, M. (Maryam), Groot, E. (Eric) de, Mathiesen, E.B. (Ellisiv), Grigore, L. (Liliana), Polak, J. (Joseph), Rundek, T. (Tatjana), Stehouwer, C.D. (Coen), Skilton, M.R. (Michael R), Hatzitolios, A.I. (Apostolos I), Savopoulos, C. (Christos), Ntaios, G. (George), Plichart, M. (Matthieu), McLachlan, S. (Stela), Kao, W.H.L. (Wen), Willeit, P. (Peter), Steinmetz, H. (Helmuth), Desvarieux, M. (Moise), Ikram, M.A. (Arfan), Johnsen, S.H., Schmidt, C. (Caroline), Willeit, J. (Johann), Ducimetiere, P. (P.), Price, J.F. (Jackie F), Bergström, G. (Göran), Kauhanen, J. (Jussi), Kiechl, S. (Stefan), Sitzer, M. (Matthias), Bickel, H. (Horst), Muir, K.W. (Keith), Hofman, A. (Albert), Völzke, H. (Henry), and Thompson, S.G. (Simon G)

Abstract

Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear. Methods and results: An individual participant meta-analysis was used to associate the annualised progression of systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol with future cardiovascular disease risk in 13 prospective cohort studies of the PROG-IMT collaboration (n = 34,072). Follow-up data included information on a combined cardiovascular disease endpoint of myocardial infarction, stroke, or vascular death. In secondary analyses, annualised progression was replaced with average. Log hazard ratios per standard deviation difference were pooled across studies by a random effects meta-analysis. In primary analysis, the annualised progression of total cholesterol was marginally related to a higher cardiovascular disease risk (hazard ratio (HR) 1.04, 95% confidence interval (CI) 1.00 to 1.07). The annualised progression of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol was not associated with future cardiovascular disease risk. In secondary analysis, average systolic blood pressure (HR 1.20 95% CI 1.11 to 1.29) and low-density lipoprotein cholesterol (HR 1.09, 95% CI 1.02 to 1.16) were related to a greater, while high-density lipoprotein cholesterol (HR 0.92, 95% CI 0.88 to 0.97) was related to a lower risk of future cardiovascular disease events. Conclusion: Averaged measurements of systolic blood pressure, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol displayed significant linear relationships with the risk of future cardiovascular disease events. However, there was no clear association between the annualised progression of these conventional risk factors in

Published
2019
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43. Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study

Author

Casula, M. a., B, Be, Olmastroni, E. a., Pirillo, A. c., Catapano, D, A. L. b., D, Jemail, Author, Lipigen, Group, Averna, M. g., Bertolini, S. h., Calandra, S. i., Tarugi, P. i., Pellegatta, F. k., Angelico, F. f., Bartuli, A. l., Biasucci, G. m., Biolo, G. n., Bonanni, L. o., Bonomo, K. p., Borghi, C. q., Bossi, A. C. r., Branchi, A. s., Carubbi, F. t., Cipollone, F. u., Citroni, N. v., Federici, M. w., Ferri, C. x., Fiorenza, A. M. y., Giaccari, A. z., Giorgino, Aa, F., Guardamagna, Ab, O., Iannuzzi, Ac, A., Iughetti, Ad, L., Lupattelli, Ae, G., Lupi, Af, A., Mandraffino, Giuseppe, Ag, G., Marcucci, Ah, R., Maroni, Ai, L., Miccoli, Aj, R., Mombelli, Ak, G., Muntoni, Al, S., Pecchioli, Am, V., Pederiva, An, C., Pipolo, Ao, A., Pisciotta, Ap, L., Pujia, Aq, A., Purrello, Ar, F., Repetti, As, E., Rubba, At, P., Sabbà, Au, C., Sampietro, Av, T., Sarzani, Aw, R., Tagliabue, M. P., Ax, Trenti, Ay, C., Vigna, G. B., Az, Werba, J. P., Ba, Zambon, Bb, S., Zenti, M. G., Bc, Minicocci, I. f., Noto, D. g., Fortunato, Bd, G., Banderali, An, G., Benso, Ax, A., Bigolin, Bb, P., Bonora, Bc, E., Bruzzi, Ad, P., Bucci, M. u., Buonuomo, P. S. l., Capra, M. E. m., Cardolini, I. w., Cefalù, B. g., Cervelli, N. x., Chiariello, Ac, G., Cocci, Aw, G., Colombo, E. y., Cremonini, A. L., Ap, D'Addato, S. q., D'Erasmo, L. f., Dal, Pino, Av, B., Sanctis, De, Ab, L., Vita, De, Ao, E., Del, Ben, M. f., Costanzo, Di, A. f., Taranto, Di, M. D., Bd, Fasano, Ay, T., Gentile, As, L., At, M., Ghirardello, Az, O., Grigore, L. k., Lussu, Al, M., Meregalli, G. r., Moffa, S. z., Montalcini, Aq, T., Morgia, Nascimbeni, F. t., Pasta, A. h., Pavanello, Ak, C., Saitta, Antonino, Ag, A., Scicali, Ar, R., Siepi, Ae, D., Spagnolli, W. v., Spina, R. g., Sticchi, Ah, E., Suppressa, Au, P., Vigo, Ba, L., Vinci, P. n., Manzato, Bf, E., Tragni, Be, E., Zampoleri, Bg, V., Casula, Manuela, Olmastroni, Elena, Pirillo, Angela, Catapano, Alberico Luigi, Arca, Marcello, Averna, Maurizio, Bertolini, Stefano, Calandra, Sebastiano, Tarugi, Patrizia, Pellegatta, Fabio, Angelico, Francesco, Bartuli, Andrea, Biasucci, Giacomo, Biolo, Gianni, Bonanni, Luca, Bonomo, Katia, Borghi, Claudio, Bossi, Antonio Carlo, Branchi, Adriana, Carubbi, Francesca, Cipollone, Francesco, Citroni, Nadia, Federici, Massimo, Ferri, Claudio, Fiorenza, Anna Maria, Giaccari, Andrea, Giorgino, Francesco, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iughetti, Lorenzo, Lupattelli, Graziana, Lupi, Alessandro, Mandraffino, Giuseppe, Marcucci, Rossella, Maroni, Lorenzo, Miccoli, Roberto, Mombelli, Giuliana, Muntoni, Sandro, Pecchioli, Valerio, Pederiva, Cristina, Pipolo, Antonio, Pisciotta, Livia, Pujia, Arturo, Purrello, Francesco, Repetti, Elena, Rubba, Paolo, Sabbà, Carlo, Sampietro, Tiziana, Sarzani, Riccardo, Tagliabue, Milena Paola, Trenti, Chiara, Vigna, Giovanni Battista, Werba, Josè Pablo, Zambon, Sabina, Zenti, Maria Grazia, Minicocci, Ilenia, Noto, Davide, Fortunato, Giuliana, Banderali, Giuseppe, Benso, Andrea, Bigolin, Paola, Bonora, Enzo, Bruzzi, Patrizia, Bucci, Marco, Buonuomo, Paola Sabrina, Capra, Maria Elena, Cardolini, Iri, Cefalù, Baldassarre, Cervelli, Nazzareno, Chiariello, Giuseppe, Cocci, Guido, Colombo, Emanuela, Cremonini, Anna Laura, D'Addato, Sergio, D'Erasmo, Laura, Dal Pino, Beatrice, De Sanctis, Luisa, De Vita, Emanuele, Del Ben, Maria, Di Costanzo, Alessia, Di Taranto, Maria Donata, Fasano, Tommaso, Gentile, Luigi, Gentile, Marco, Ghirardello, Omar, Grigore, Liliana, Lussu, Milena, Meregalli, Giancarla, Moffa, Simona, Montalcini, Tiziana, Morgia, Valeria, Nascimbeni, Fabio, Pasta, Andrea, Pavanello, Chiara, Saitta, Antonino, Scicali, Roberto, Siepi, Donatella, Spagnolli, Walter, Spina, Rossella, Sticchi, Elena, Suppressa, Patrizia, Vigo, Lorenzo, Vinci, Pierandrea, Manzato, Enzo, Tragni, Elena, Zampoleri, Veronica, D'addato, Sergio, D'erasmo, Laura, Casula, M, Olmastroni, E, Pirillo, A, Catapano, A, Averna, M, Noto, D, Cefalu, B, and Spina, R

Subjects
Male, Settore MED/09 - Medicina Interna, Genetic testing, Predictive Value of Test, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, Decision Support Technique, 0302 clinical medicine, Retrospective Studie, Risk Factors, Cardiovascular Disease, Genetic Marker, Prospective Studies, 030212 general & internal medicine, Age of Onset, Prospective cohort study, education.field_of_study, medicine.diagnostic_test, Middle Aged, Dutch Lipid Clinic Network score, Adult, Biomarkers, Cardiovascular Diseases, Cholesterol, LDL, Female, Genetic Markers, Genetic Predisposition to Disease, Genetic Testing, Humans, Hyperlipoproteinemia Type II, Italy, Phenotype, Predictive Value of Tests, Reproducibility of Results, Retrospective Studies, Risk Assessment, Decision Support Techniques, Mutation, 3. Good health, Cholesterol, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, Population, Reproducibility of Result, Physical examination, LDL, 03 medical and health sciences, Internal medicine, medicine, First-degree relatives, education, business.industry, Risk Factor, Settore MED/13 - ENDOCRINOLOGIA, Biomarker, medicine.disease, Missing data, Dutch Lipid Clinic Network score, Familial hypercholesterolemia, Genetic testing, Prospective Studie, Age of onset, business
Abstract

Background and aims Familial hypercholesterolemia (FH) is an inherited disorder characterized by high levels of blood cholesterol from birth and premature coronary heart disease. Thus, the identification of FH patients is crucial to prevent or delay the onset of cardiovascular events, and the availability of a tool helping with the diagnosis in the setting of general medicine is essential to improve FH patient identification. Methods This study evaluated the performance of the Dutch Lipid Clinic Network (DLCN) score in FH patients enrolled in the LIPIGEN study, an Italian integrated network aimed at improving the identification of patients with genetic dyslipidaemias, including FH. Results The DLCN score was applied on a sample of 1377 adults (mean age 42.9 ± 14.2 years) with genetic diagnosis of FH, resulting in 28.5% of the sample classified as probable FH and 37.9% as classified definite FH. Among these subjects, 43.4% had at least one missing data out of 8, and about 10.0% had 4 missing data or more. When analyzed based on the type of missing data, a higher percentage of subjects with at least 1 missing data in the clinical history or physical examination was classified as possible FH (DLCN score 3–5). We also found that using real or estimated pre-treatment LDL-C levels may significantly modify the DLCN score. Conclusions Although the DLCN score is a useful tool for physicians in the diagnosis of FH, it may be limited by the complexity to retrieve all the essential information, suggesting a crucial role of the clinical judgement in the identification of FH subjects.

Published
2018

46. Post-Prandial Lipemia And Cd36

Author

Zampoleri, V., primary, Baragetti, A., additional, Bonacina, F., additional, Pedretti, S., additional, Grigore, L., additional, Pellegatta, F., additional, Redaelli, L., additional, Mitro, N., additional, Norata, D.G., additional, and Catapano, A.L., additional

Published
2019
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49. Life-Style And Cardio-Metabolic Profile Of A Population Living In A Clustered Alpine Village (The Plic Chiesa Study): Comparison With An Urban Cohort (Plic Study)

Author

Magni, P., primary, Baragetti, A., additional, Casula, M., additional, Grigore, L., additional, Olmastroni, E., additional, Pellegatta, F., additional, Redaelli, L., additional, Tidone, C., additional, Zampoleri, V., additional, Tragni, E., additional, and Catapano, A.L., additional

Published
2019
Full Text
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