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5 results on '"Grimaldi, Izabella"'

1. CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma

Author

Geraldo, Luiz Henrique, Garcia, Celina, Xu, Yunling, Leser, Felipe Saceanu, Grimaldi, Izabella, de Camargo Magalhães, Eduardo Sabino, Dejaegher, Joost, Solie, Lien, Pereira, Cláudia Maria, Correia, Ana Helena, De Vleeschouwer, Steven, Tavitian, Bertrand, Canedo, Nathalie Henriques Silva, Mathivet, Thomas, Thomas, Jean-Leon, Eichmann, Anne, and Lima, Flavia Regina Souza

Published
2023
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3. The multiple functions of the co-chaperone stress inducible protein 1

Author

da Fonseca, Anna Carolina Carvalho, Matias, Diana, Geraldo, Luiz Henrique Medeiros, Leser, Felipe Saceanu, Pagnoncelli, Iohana, Garcia, Celina, do Amaral, Rackele Ferreira, da Rosa, Barbara Gomes, Grimaldi, Izabella, de Camargo Magalhães, Eduardo Sabino, Cóppola-Segovia, Valentín, de Azevedo, Evellyn Mayla, Zanata, Silvio Marques, and Lima, Flavia Regina Souza

Published
2021
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4. Glioblastoma Therapy in the Age of Molecular Medicine

Author

Geraldo, Luiz Henrique Medeiros, Garcia, Celina, da Fonseca, Anna Carolina Carvalho, Dubois, Luiz Gustavo Feijó, de Sampaio e Spohr, Tânia Cristina Leite, Matias, Diana, de Camargo Magalhães, Eduardo Sabino, do Amaral, Rackele Ferreira, da Rosa, Barbara Gomes, Grimaldi, Izabella, Leser, Felipe Sceanu, Janeiro, José Marcos, Macharia, Lucy, Wanjiru, Caroline, Pereira, Claudia Maria, Moura-Neto, Vivaldo, Freitas, Catarina, and Lima, Flavia Regina Souza

Published
2019
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5. The multiple functions of PrPC in physiological, cancer, and neurodegenerative contexts.

Author

Grimaldi, Izabella, Leser, Felipe Saceanu, Janeiro, José Marcos, da Rosa, Bárbara Gomes, Campanelli, Ana Clara, Romão, Luciana, and Lima, Flavia Regina Souza

Subjects
*ALZHEIMER'S disease, *DEGENERATION (Pathology), *CANCER stem cells, *PARKINSON'S disease, *DISEASE progression, *HOMEOSTASIS, *LUNGS, *NEURODEGENERATION
Abstract

Cellular prion protein (PrPC) is a highly conserved glycoprotein, present both anchored in the cell membrane and soluble in the extracellular medium. It has a diversity of ligands and is variably expressed in numerous tissues and cell subtypes, most notably in the central nervous system (CNS). Its importance has been brought to light over the years both under physiological conditions, such as embryogenesis and immune system homeostasis, and in pathologies, such as cancer and neurodegenerative diseases. During development, PrPC plays an important role in CNS, participating in axonal growth and guidance and differentiation of glial cells, but also in other organs such as the heart, lung, and digestive system. In diseases, PrPC has been related to several types of tumors, modulating cancer stem cells, enhancing malignant properties, and inducing drug resistance. Also, in non-neoplastic diseases, such as Alzheimer's and Parkinson's diseases, PrPC seems to alter the dynamics of neurotoxic aggregate formation and, consequently, the progression of the disease. In this review, we explore in detail the multiple functions of this protein, which proved to be relevant for understanding the dynamics of organism homeostasis, as well as a promising target in the treatment of both neoplastic and degenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2022
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