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202 results on '"Grisoli, Pietro"'

5. Pontastacus leptodactylus (Eschscholtz, 1823) and Faxonius limosus (Rafinesque, 1817) as New, Alternative Sources of Chitin and Chitosan

Author

Nuc, Zofia, primary, Brusotti, Gloria, additional, Catenacci, Laura, additional, Grenha, Ana, additional, Pontes, Jorge F., additional, Pinto da Silva, Joana, additional, Rosa da Costa, Ana Maria, additional, Moro, Paola, additional, Milanese, Chiara, additional, Grisoli, Pietro, additional, Sorrenti, Milena, additional, Dobrzycka-Krahel, Aldona, additional, Bonferoni, Maria Cristina, additional, and Caramella, Carla Marcella, additional

Published
2023
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7. Characterization and Molecular Modelling of Non-Antibiotic Nanohybrids for Wound Healing Purposes

Author

Valentino, Caterina, primary, Martínez Rodríguez, Tomás, additional, Borrego-Sánchez, Ana, additional, Hernández Benavides, Pablo, additional, Arrebola Vargas, Francisco, additional, Paredes, José Manuel, additional, Rossi, Silvia, additional, Sainz Díaz, Claro Ignacio, additional, Sandri, Giuseppina, additional, Grisoli, Pietro, additional, Medina Pérez, María del Mar, additional, and Aguzzi, Carola, additional

Published
2023
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9. Characterization and Molecular Modelling of Non-Antibiotic Nanohybrids for Wound Healing Purposes

Author

Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Junta de Andalucía, Valentino, Caterina, Martínez Rodríguez, Tomás, Borrego Sánchez, Ana, Hernández Benavides, Pablo, Arrebola Vargas, Francisco, Paredes, José Manuel, Rossi, Silvia, Sainz-Díaz, C. Ignacio, Sandri, Giuseppina, Grisoli, Pietro, Medina Pérez, María del Mar, Aguzzi, Carola, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Junta de Andalucía, Valentino, Caterina, Martínez Rodríguez, Tomás, Borrego Sánchez, Ana, Hernández Benavides, Pablo, Arrebola Vargas, Francisco, Paredes, José Manuel, Rossi, Silvia, Sainz-Díaz, C. Ignacio, Sandri, Giuseppina, Grisoli, Pietro, Medina Pérez, María del Mar, and Aguzzi, Carola

Abstract

The healing process of chronic wounds continues to be a current clinical challenge, worsened by the risk of microbial infections and bacterial resistance to the most frequent antibiotics. In this work, non-antibiotic nanohybrids based on chlorhexidine dihydrochloride and clay minerals have been developed in order to design advanced therapeutic systems aimed to enhance wound healing in chronic lesions. To prepare the nanohybrids, two methodologies have been compared: the intercalation solution procedure and the spray-drying technique, the latter as a one-step process able to reduce preparation times. Nanohybrids were then fully studied by solid state characterization techniques. Computational calculations were also performed to assess the interactions between the drug and the clays at the molecular level. In vitro human fibroblast biocompatibility and antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa were assessed to check biocompatibility and potential microbicidal effects of the obtained nanomaterials. The results demonstrated the effective organic/inorganic character of the nanohybrids with homogeneous drug distribution into the clayey structures, which had been confirmed by classical mechanics calculations. Good biocompatibility and microbicidal effects were also observed, especially for the spray-dried nanohybrids. It was suggested that it could be due to a greater contact area with target cells and bacterial suspensions.

Published
2023

12. A Supramolecular Approach to Antimicrobial Surfaces

Author

Gazzola, Valentina, primary, Grisoli, Pietro, additional, Amendola, Valeria, additional, Dacarro, Giacomo, additional, Mangano, Carlo, additional, Pallavicini, Piersandro, additional, Poggi, Antonio, additional, Rossi, Silvia, additional, Vigani, Barbara, additional, and Taglietti, Angelo, additional

Published
2022
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20. Montmorillonite-norfloxacin nanocomposite intended for healing of infected wounds

Author

García-Villén,Fátima, Faccendini,Angela, Aguzzi,Carola, Cerezo,Pilar, Bonferoni,Maria Cristina, Rossi,Silvia, Grisoli,Pietro, Ruggeri,Marco, Ferrari,Franca, Sandri,Giuseppina, and Viseras,Cesar

Subjects
Male, Staphylococcus aureus, Wound Healing, nanocomposite, Temperature, Biological Availability, norfloxacin, montmorillonite, solid state characterization, Microbial Sensitivity Tests, Nanocomposites, Drug Liberation, Anti-Infective Agents, X-Ray Diffraction, International Journal of Nanomedicine, Pseudomonas aeruginosa, Spectroscopy, Fourier Transform Infrared, Bentonite, Wound Infection, Humans, Adsorption, Original Research
Abstract

Fatima García-Villén,1 Angela Faccendini,2 Carola Aguzzi,1 Pilar Cerezo,1 Maria Cristina Bonferoni,2 Silvia Rossi,2 Pietro Grisoli,2 Marco Ruggeri,2 Franca Ferrari,2 Giuseppina Sandri,2 Cesar Viseras11Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Campus of Cartuja, Granada, Spain; 2Department of Drug Sciences, Faculty of Pharmacy, University of Pavia, Pavia 27100, ItalyBackground: Chronic cutaneous wounds represent amajor issue in medical care and are often prone to infections.Purpose: The aim of this study was the design of a clay mineral-drug nanocomposite based on montmorillonite and norfloxacin (NF, antimicrobial drug) as a powder for cutaneous application, to enhance wound healing in infected skin lesions.Methods: The nanocomposite has been prepared by means of an intercalation solution procedure. Adsorption isotherm, solid-state characterization of the nanocomposite, drug loading capacity and its release have been performed. Moreover, cytocompatibility, in vitro fibroblast proliferation and antimicrobial activity against Pseudomonas aeruginosa and Staphylococcus aureus were assessed.Results: The clay drug adsorption isotherm demonstrates that the mechanism of NF intercalation into montmorillonite galleries is the adsorption as one single process, due to the charge–charge interaction between protonated NF and negatively charged montmorillonite edges in the interlayer space. Nanocomposite is biocompatible and it is characterized by antimicrobial activity greater than the free drug: this is due to its nanostructure and controlled drug release properties.Conclusion: Considering the results obtained, NF–montmorillonite nanocomposite seems a promising tool to treat infected skin lesions or skin wounds prone to infection, as chronic ulcers (diabetic foot, venous leg ulcers) and burns.Keywords: montmorillonite, norfloxacin, nanocomposite, solid state characterization, wound healing

Published
2019

22. PVA Films with Mixed Silver Nanoparticles and Gold Nanostars for Intrinsic and Photothermal Antibacterial Action

Author

Grisoli, Pietro, primary, De Vita, Lorenzo, additional, Milanese, Chiara, additional, Taglietti, Angelo, additional, Diaz Fernandez, Yuri, additional, Bouzin, Margaux, additional, D’Alfonso, Laura, additional, Sironi, Laura, additional, Rossi, Silvia, additional, Vigani, Barbara, additional, Sperandeo, Paola, additional, Polissi, Alessandra, additional, and Pallavicini, Piersandro, additional

Published
2021
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24. A chemometric assessment and profiling of the essential oils from Hibiscus sabdariffa L. from Kurdistan, Iraq.

Author

Ibrahim, Mohammed Farhad, Robustelli della Cuna, Francesco Saverio, Villa, Carla, Corti, Marco, Amin, Hawraz Ibrahim M., Faris, Pawan, Grisoli, Pietro, and Brusotti, Gloria

Subjects
ROSELLE, ESSENTIAL oils, HERBAL teas, CHEMOMETRICS, COMMON cold, TROPICAL plants
Abstract

Hibiscus sabdariffa L. is a tropical plant belonging to the Malvaceae family. In Kurdistan, the Autonomous Region of Iraq, water infusion of H. sabdariffa calyces is recommended for the treatment of hypotension and the common cold. Three distillation techniques: hydrodistillation (HD), steam distillation (SD), and solvent-free microwave-assisted extraction (SFME) have been compared to obtain the essential oils from calyces. The composition of the extracts was investigated by GC-FID and GC-MS. A total of 62 compounds have been identified, from which 55 components were found in HD distillates (95.75%), 37 components in SFME (96.06%), and 29 in SD (99.63%). Chemometric tools were applied to optimise and evidence the relation between distillation techniques and composition of the obtained essential oils as an investigation for the essential oils commercialisation approach of Hibiscus sabdariffa L. that have been done from a long time using conventional hydrodistillation in the local Herbal and Tea markets in Kurdistan. [ABSTRACT FROM AUTHOR]

Published
2022
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29. GMP-compliant sponge-like dressing containing MSC lyo-secretome: Proteomic network of healing in a murine wound model

Author

Bari, Elia, primary, Di Silvestre, Dario, additional, Mastracci, Luca, additional, Grillo, Federica, additional, Grisoli, Pietro, additional, Marrubini, Giorgio, additional, Nardini, Marta, additional, Mastrogiacomo, Maddalena, additional, Sorlini, Marzio, additional, Rossi, Rossana, additional, Torre, Maria Luisa, additional, Mauri, Pierluigi, additional, Sesana, Giovanni, additional, and Perteghella, Sara, additional

Published
2020
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36. Chitosan/Glycosaminoglycan Scaffolds: The Role of Silver Nanoparticles to Control Microbial Infections in Wound Healing

Author

Sandri, Giuseppina, primary, Miele, Dalila, additional, Faccendini, Angela, additional, Bonferoni, Maria Cristina, additional, Rossi, Silvia, additional, Grisoli, Pietro, additional, Taglietti, Angelo, additional, Ruggeri, Marco, additional, Bruni, Giovanna, additional, Vigani, Barbara, additional, and Ferrari, Franca, additional

Published
2019
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41. Essential oil-loaded lipid nanoparticles for wound healing

Author

Saporito, Francesca, primary, Sandri, Giuseppina, additional, Bonferoni, Maria Cristina, additional, Rossi, Silvia, additional, Boselli, Cinzia, additional, Icaro Cornaglia, Antonia, additional, Mannucci, Barbara, additional, Grisoli, Pietro, additional, Vigani, Barbara, additional, and Ferrari, Franca, additional

Published
2017
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42. Modular approach for bimodal antibacterial surfaces combining photo-switchable activity and sustained biocidal release

Author

Pallavicini, P, Bassi, B, Chirico, G, Collini, M, Dacarro, G, Fratini, E, Grisoli, P, Patrini, M, Sironi, L, Taglietti, A, Moritz, M, Sorzabal-Bellido, I, Susarrey-Arce, A, Latter, E, Beckett, A, Prior, I, Raval, R, Diaz Fernandez, Y, Pallavicini, Piersandro, Bassi, Barbara, Chirico, Giuseppe, Collini, Maddalena, Dacarro, Giacomo, Fratini, Emiliano, Grisoli, Pietro, Patrini, Maddalena, Sironi, Laura, Taglietti, Angelo, Moritz, Marcel, Sorzabal-Bellido, Ioritz, Susarrey-Arce, Arturo, Latter, Edward, Beckett, Alison J., Prior, Ian A., Raval, Rasmita, Diaz Fernandez, Yuri A., Pallavicini, P, Bassi, B, Chirico, G, Collini, M, Dacarro, G, Fratini, E, Grisoli, P, Patrini, M, Sironi, L, Taglietti, A, Moritz, M, Sorzabal-Bellido, I, Susarrey-Arce, A, Latter, E, Beckett, A, Prior, I, Raval, R, Diaz Fernandez, Y, Pallavicini, Piersandro, Bassi, Barbara, Chirico, Giuseppe, Collini, Maddalena, Dacarro, Giacomo, Fratini, Emiliano, Grisoli, Pietro, Patrini, Maddalena, Sironi, Laura, Taglietti, Angelo, Moritz, Marcel, Sorzabal-Bellido, Ioritz, Susarrey-Arce, Arturo, Latter, Edward, Beckett, Alison J., Prior, Ian A., Raval, Rasmita, and Diaz Fernandez, Yuri A.

Abstract

Photo-responsive antibacterial surfaces combining both on-demand photo-switchable activity and sustained biocidal release were prepared using sequential chemical grafting of nano-objects with different geometries and functions. The multi-layered coating developed incorporates a monolayer of near-infrared active silica-coated gold nanostars (GNS) decorated by silver nanoparticles (AgNP). This modular approach also enables us to unravel static and photo-activated contributions to the overall antibacterial performance of the surfaces, demonstrating a remarkable synergy between these two mechanisms. Complementary microbiological and imaging evaluations on both planktonic and surface-attached bacteria provided new insights on these distinct but cooperative effects.

Published
2017

43. Essential oil-loaded lipid nanoparticles for wound healing

Author

Saporito,Francesca, Sandri,Giuseppina, Bonferoni,Maria Cristina, Rossi,Silvia, Boselli,Cinzia, Icaro Cornaglia,Antonia, Mannucci,Barbara, Grisoli,Pietro, Vigani,Barbara, Ferrari,Franca, Saporito,Francesca, Sandri,Giuseppina, Bonferoni,Maria Cristina, Rossi,Silvia, Boselli,Cinzia, Icaro Cornaglia,Antonia, Mannucci,Barbara, Grisoli,Pietro, Vigani,Barbara, and Ferrari,Franca

Abstract

Francesca Saporito,1 Giuseppina Sandri,1 Maria Cristina Bonferoni,1 Silvia Rossi,1 Cinzia Boselli,1 Antonia Icaro Cornaglia,2 Barbara Mannucci,3 Pietro Grisoli,1 Barbara Vigani,1 Franca Ferrari1 1Department of Drug Sciences, University of Pavia, Pavia, 2Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, 3Centro Grandi Strumenti, University of Pavia, Pavia, Italy Abstract: Chronic wounds and severe burns are diseases responsible for severe morbidity and even death. Wound repair is a crucial process and tissue regeneration enhancement and infection prevention are key factors to minimize pain, discomfort, and scar formation. The aim of this work was the development of lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers [NLC]), to be loaded with eucalyptus or rosemary essential oils and to be used, as medical devices, to enhance healing of skin wounds. Lipid nanoparticles were based on natural lipids: cocoa butter, as solid lipid, and olive oil or sesame oil, as liquid lipids. Lecithin was chosen as surfactant to stabilize nanoparticles and to prevent their aggregation. The systems were prepared by high shear homogenization followed by ultrasound application. Nanoparticles were characterized for physical–chemical properties, bioadhesion, cytocompatibility, in vitro proliferation enhancement, and wound healing properties toward normal human dermal fibroblasts. Antimicrobial activity of nanoparticles was evaluated against two reference microbial strains, one of Staphylococcus aureus, the other of Streptococcus pyogenes. Finally, the capability of nanoparticles to promote wound healing in vivo was evaluated on a rat burn model. NLC based on olive oil and loaded with eucalyptus oil showed appropriate physical–chemical properties, good bioadhesion, cytocompatibility, in vitro proliferation enhancement, and wound healing properties toward fibroblasts, associated to antimicrobial propert

Published
2017

44. Self-assembled monolayers of Prussian blue nanoparticles with photothermal effect

Author

Dacarro, G, Grisoli, P, Borzenkov, M, Milanese, C, Fratini, E, Ferraro, G, Taglietti, A, Pallavicini, P, Dacarro, Giacomo, Grisoli, Pietro, Borzenkov, Mykola, Milanese, Chiara, Fratini, Emiliano, Ferraro, Giovanni, Taglietti, Angelo, Pallavicini, Piersandro, Dacarro, G, Grisoli, P, Borzenkov, M, Milanese, C, Fratini, E, Ferraro, G, Taglietti, A, Pallavicini, P, Dacarro, Giacomo, Grisoli, Pietro, Borzenkov, Mykola, Milanese, Chiara, Fratini, Emiliano, Ferraro, Giovanni, Taglietti, Angelo, and Pallavicini, Piersandro

Abstract

A photo-responsive antibacterial surface was prepared grafting non-toxic Prussian blue nanoparticles on a functionalized glass surface. Colloidal Prussian blue was synthesized as nanoparticles with cubic shape and grafted on a polyamine-functionalized SiO2 surface, obtaining a good coverage and a homogeneous distribution of the nanocubes. Irradiation of these samples in the so-called bio-transparent window' of the near-infrared allows to exert a triggered antibacterial effect

Published
2017

46. Modular approach for bimodal antibacterial surfaces combining photo-switchable activity and sustained biocidal release

Author

Pallavicini, Piersandro, primary, Bassi, Barbara, additional, Chirico, Giuseppe, additional, Collini, Maddalena, additional, Dacarro, Giacomo, additional, Fratini, Emiliano, additional, Grisoli, Pietro, additional, Patrini, Maddalena, additional, Sironi, Laura, additional, Taglietti, Angelo, additional, Moritz, Marcel, additional, Sorzabal-Bellido, Ioritz, additional, Susarrey-Arce, Arturo, additional, Latter, Edward, additional, Beckett, Alison J., additional, Prior, Ian A., additional, Raval, Rasmita, additional, and Diaz Fernandez, Yuri A., additional

Published
2017
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48. Application of Airborne Microorganism Indexes in Offices, Gyms, and Libraries.

Author

Grisoli, Pietro, Albertoni, Marco, and Rodolfi, Marinella

Subjects
NAVICULA, MICROBIAL contamination, AIR quality indexes, GYMNASIUMS, AIR quality
Abstract

The determination of microbiological air quality in sporting and working environments requires the quantification of airborne microbial contamination. The number and types of microorganisms, detected in a specific site, offer a useful index for air quality valuation. An assessment of contamination levels was carried out using three evaluation indices for microbiological pollution: the global index of microbiological contamination per cubic meter (GIMC/m3), the index of mesophilic bacterial contamination (IMC), and the amplification index (AI). These indices have the advantage of considering several concomitant factors in the formation of a microbial aerosol. They may also detect the malfunction of an air treatment system due to the increase of microbes in aeraulic ducts, or inside a building compared to the outdoor environment. In addition, they highlight the low efficiency of a ventilation system due to the excessive number of people inside a building or to insufficient air renewal. This study quantified the levels of microorganisms present in the air in different places such as offices, gyms, and libraries. The air contamination was always higher in gyms that in the other places. All examined environments are in Northern Italy. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Isolamento ed identificazione di componenti del vino ad attività antibatterica

Author

Daglia Maria, Papetti Adele, Grisoli Pietro, Aceti Camilla, Corradini C., Dacarro Cesare, Gazzani Gabriella, Daglia, Maria, Papetti, Adele, Grisoli, Pietro, Aceti, Camilla, Corradini, C., Dacarro, Cesare, and Gazzani, Gabriella

Subjects
red and white wine, antibacterial activity, organic acids
Abstract

Studi condotti negli ultimi due decenni hanno messo in evidenza numerose attività biologiche possedute dal vino oltre a quelle dovute al suo contenuto in etanolo. E’ ormai accertato che un moderato consumo di vino determina una diminuzione del rischio di sviluppare gravi e diffuse patologie croniche quali neoplasie e malattie cardio-vascolari. E’ stato dimostrato che gli effetti positivi della bevanda sono dovuti alle proprietà antiossidanti e antiradicaliche dei componenti polifenolici dei quali è particolarmente ricco il vino rosso. Esso possiede anche attività antibatterica nei confronti di diversi microrganismi tra cui l’Helicobacter pilori. Questa attività biologica è dovuta al resveratrolo, derivato stilbenico che nei vegetali ha funzione di fitoalexina. Il resveratrolo è risultato attivo anche contro alcuni batteri e dermatofiti, responsabili delle più comuni infezioni della pelle umana. Il vino è inoltre risultato attivo in vitro nei confronti di numerosi batteri enteropatogeni. In questo caso è risultato responsabile dell’attività l’acido acetico contenuto nella bevanda. In considerazione del fatto che la bevanda viene ripetutamente consumata durante un pasto e che per questo la sua azione potrebbe essere particolarmente importante per la salute del cavo orale, abbiamo esteso lo studio dell’attività antibatterica e battericida del vino verificando gli effetti nel vino bianco nei confronti degli Streptococchi orali che svolgono un ruolo importante nello sviluppo della carie e delle patologie parodontali. Un campione di vino bianco del commercio è stato saggiato nei confronti di nove Streptococchi colonizzatori del cavo orale. Esso è risultato attivo contro numerosi Streptococchi compreso lo S. mutans, il principale agente eziologico della carie. L’isolamento dal campione di vino analizzato dei componenti attivi è stato condotto mediante dialisi seguita da estrazione in fase solida. E’ risultata attiva la frazione costituita dai componenti più polari indicando che l’attività rilevata per la bevanda, potrebbe essere dovuta agli acidi organici prodotti durante il processo di fermentazione. L’attività di tali acidi contro lo S. mutans è stata verificata utilizzando standards del commercio. Il più attivo è risultato l’acido succinico seguito dall’acido malico, lattico, tartarico, citrico e acetico.

Published
2006

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