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40 results on '"Grkovic, Ivica"'

15. A Bone in the Rat’s Heart

Author

Aljinovic, Jure, primary, Vukojevic, Katarina, additional, Saraga-Babic, Mirna, additional, Marinovic Guic, Maja, additional, Kosta, Vana, additional, Poljicanin, Ana, additional, and Grkovic, Ivica, additional

Published
2016
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16. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Author

Soler Artigas, María, Loth, Daan W, Wain, Louise V, Gharib, Sina A, Obeidat, Ma'en, Tang, Wenbo, Zhai, Guangju, Zhao, Jing Hua, Smith, Albert Vernon, Huffman, Jennifer E, Albrecht, Eva, Jackson, Catherine M, Evans, David M, Cadby, Gemma, Fornage, Myriam, Manichaikul, Ani, Lopez, Lorna M, Johnson, Toby, Aldrich, Melinda C, Aspelund, Thor, Barroso, Inês, Campbell, Harry, Cassano, Patricia A, Couper, David J, Eiriksdottir, Gudny, Franceschini, Nora, Garcia, Melissa, Gieger, Christian, Gislason, Gauti Kjartan, Grkovic, Ivica, Hammond, Christopher J, Hancock, Dana B, Harris, Tamara B, Ramasamy, Adaikalavan, Heckbert, Susan R, Heliövaara, Markku, Homuth, Georg, Hysi, Pirro G, James, Alan L, Jankovic, Stipan, Joubert, Bonnie R, Karrasch, Stefan, Klopp, Norman, Koch, Beate, Kritchevsky, Stephen B, Launer, Lenore J, Liu, Yongmei, Loehr, Laura R, Lohman, Kurt, Loos, Ruth JF, Lumley, Thomas, Al Balushi, Khalid A, Ang, Wei Q, Barr, R Graham, Beilby, John, Blakey, John D, Boban, Mladen, Boraska, Vesna, Brisman, Jonas, Britton, John R, Brusselle, Guy G, Cooper, Cyrus, Curjuric, Ivan, Dahgam, Santosh, Deary, Ian J, Ebrahim, Shah, Eijgelsheim, Mark, Francks, Clyde, Gaysina, Darya, Granell, Raquel, Gu, Xiangjun, Hankinson, John L, Hardy, Rebecca, Harris, Sarah E, Henderson, John, Henry, Amanda, Hingorani, Aroon D, Hofman, Albert, Holt, Patrick G, Hui, Jennie, Hunter, Michael L, Imboden, Medea, Jameson, Karen A, Kerr, Shona M, Kolcic, Ivana, Kronenberg, Florian, Liu, Jason Z, Marchini, Jonathan, McKeever, Tricia, Morris, Andrew D, Olin, Anna-Carin, Porteous, David J, Postma, Dirkje S, Rich, Stephen S, Ring, Susan M, Rivadeneira, Fernando, Rochat, Thierry, Sayer, Avan Aihie, Sayers, Ian, Sly, Peter D, Smith, George Davey, Sood, Akshay, Starr, John M, Uitterlinden, André G, Vonk, Judith M, Wannamethee, S Goya, Whincup, Peter H, Wijmenga, Cisca, Williams, O Dale, Wong, Andrew, Mangino, Massimo, Marciante, Kristin D, McArdle, Wendy L, Meibohm, Bernd, Morrison, Alanna C, North, Kari E, Omenaas, Ernst, Palmer, Lyle J, Pietiläinen, Kirsi H, Pin, Isabelle, Pola Sbreve Ek, Ozren, Pouta, Anneli, Psaty, Bruce M, Hartikainen, Anna-Liisa, Rantanen, Taina, Ripatti, Samuli, Rotter, Jerome I, Rudan, Igor, Rudnicka, Alicja R, Schulz, Holger, Shin, So-Youn, Spector, Tim D, Surakka, Ida, Vitart, Veronique, Völzke, Henry, Wareham, Nicholas J, Warrington, Nicole M, Wichmann, H-Erich, Wild, Sarah H, Wilk, Jemma B, Wjst, Matthias, Wright, Alan F, Zgaga, Lina, Zemunik, Tatijana, Pennell, Craig E, Nyberg, Fredrik, Kuh, Diana, Holloway, John W, Boezen, H Marike, Lawlor, Debbie A, Morris, Richard W, Probst-Hensch, Nicole, International Lung Cancer Consortium, GIANT consortium, Kaprio, Jaakko, Wilson, James F, Hayward, Caroline, Kähönen, Mika, Heinrich, Joachim, Musk, Arthur W, Jarvis, Deborah L, Gläser, Sven, Järvelin, Marjo-Riitta, Ch Stricker, Bruno H, Elliott, Paul, O'Connor, George T, Strachan, David P, London, Stephanie J, Hall, Ian P, Gudnason, Vilmundur, and Tobin, Martin D

Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

Published
2011

17. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Author

Smith, Albert Vernon, Cassano, Patricia A, Zhao, Jing Hua, Eiriksdottir, Gudny, Gislason, Gauti Kjartan, Huffman, Jennifer E, Manichaikul, Ani, Garcia, Melissa, Obeidat, Ma'en, Jackson, Catherine M, Franceschini, Nora, Gieger, Christian, Grkovic, Ivica, Lopez, Lorna M, Wain, Louise V, Albrecht, Eva, Gharib, Sina A, Loth, Daan W, Hancock, Dana B, Aldrich, Melinda C, Hammond, Christopher J, Evans, David M, Zhai, Guangju, Cadby, Gemma, Aspelund, Thor, Artigas, María Soler, Fornage, Myriam, Barroso, Inês, Johnson, Toby, Tang, Wenbo, Campbell, Harry, and Couper, David J

Abstract

Pulmonary function measures reflect respiratory health and predict mortality, and are used in the diagnosis of chronic obstructive pulmonary disease (COPD). We tested genome-wide association with the forced expiratory volume in 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in 48,201 individuals of European ancestry, with follow-up of top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P

Published
2011
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20. General anatomy principles and applications

Author

Eizenberg, Norman, Briggs, Christopher, Adams, Craig, Ahern, Gerard, Barker, Priscilla, Grkovic, Ivica, and Pitman, Alexander

Subjects
anatomy, general, principles, applications
Abstract

General anatomy principles and applications

Published
2008

28. A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample

Author

Obeidat, Ma'en, Wain, Louise V., Shrine, Nick, Kalsheker, Noor, Artigas, Maria Soler, Repapi, Emmanouela, Burton, Paul R., Johnson, Toby, Ramasamy, Adaikalavan, Zhao, Jing Hua, Zhai, Guangju, Huffman, Jennifer E., Vitart, Veronique, Albrecht, Eva, Igl, Wilmar, Hartikainen, Anna-Liisa, Pouta, Anneli, Cadby, Gemma, Hui, Jennie, Palmer, Lyle J., Hadley, David, McArdle, Wendy L., Rudnicka, Alicja R., Barroso, Ines, Loos, Ruth J. F., Wareham, Nicholas J., Mangino, Massimo, Soranzo, Nicole, Spector, Tim D., Glaeser, Sven, Homuth, Georg, Voelzke, Henry, Deloukas, Panos, Granell, Raquel, Henderson, John, Grkovic, Ivica, Jankovic, Stipan, Zgaga, Lina, Polasek, Ozren, Rudan, Igor, Wright, Alan F., Campbell, Harry, Wild, Sarah H., Wilson, James F., Heinrich, Joachim, Imboden, Medea, Probst-Hensch, Nicole M., Gyllensten, Ulf, Johansson, Åsa, Zaboli, Ghazal, Mustelin, Linda, Rantanen, Taina, Surakka, Ida, Kaprio, Jaakko, Jarvelin, Marjo-Riitta, Hayward, Caroline, Evans, David M., Koch, Beate, Musk, Arthur William, Elliott, Paul, Strachan, David P., Tobin, Martin D., Sayers, Ian, Hall, Ian P., Obeidat, Ma'en, Wain, Louise V., Shrine, Nick, Kalsheker, Noor, Artigas, Maria Soler, Repapi, Emmanouela, Burton, Paul R., Johnson, Toby, Ramasamy, Adaikalavan, Zhao, Jing Hua, Zhai, Guangju, Huffman, Jennifer E., Vitart, Veronique, Albrecht, Eva, Igl, Wilmar, Hartikainen, Anna-Liisa, Pouta, Anneli, Cadby, Gemma, Hui, Jennie, Palmer, Lyle J., Hadley, David, McArdle, Wendy L., Rudnicka, Alicja R., Barroso, Ines, Loos, Ruth J. F., Wareham, Nicholas J., Mangino, Massimo, Soranzo, Nicole, Spector, Tim D., Glaeser, Sven, Homuth, Georg, Voelzke, Henry, Deloukas, Panos, Granell, Raquel, Henderson, John, Grkovic, Ivica, Jankovic, Stipan, Zgaga, Lina, Polasek, Ozren, Rudan, Igor, Wright, Alan F., Campbell, Harry, Wild, Sarah H., Wilson, James F., Heinrich, Joachim, Imboden, Medea, Probst-Hensch, Nicole M., Gyllensten, Ulf, Johansson, Åsa, Zaboli, Ghazal, Mustelin, Linda, Rantanen, Taina, Surakka, Ida, Kaprio, Jaakko, Jarvelin, Marjo-Riitta, Hayward, Caroline, Evans, David M., Koch, Beate, Musk, Arthur William, Elliott, Paul, Strachan, David P., Tobin, Martin D., Sayers, Ian, and Hall, Ian P.

Abstract

Rationale: Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium). Objectives: To comprehensively analyse previously reported genetic associations with lung function measures, and to investigate whether single nucleotide polymorphisms (SNPs) in these genomic regions are associated with lung function in a large population sample. Methods: We analysed association for SNPs tagging 130 genes and 48 intergenic regions (+/-10 kb), after conducting a systematic review of the literature in the PubMed database for genetic association studies reporting lung function associations. Results: The analysis included 16,936 genotyped and imputed SNPs. No loci showed overall significant association for FEV1 or FEV1/FVC traits using a carefully defined significance threshold of 1.3 x 10(-5). The most significant loci associated with FEV1 include SNPs tagging MACROD2 (P = 6.81 x 10(-5)), CNTN5 (P = 4.37 x 10(-4)), and TRPV4 (P = 1.58 x 10(-3)). Among ever-smokers, SERPINA1 showed the most significant association with FEV1 (P = 8.41 x 10(-5)), followed by PDE4D (P = 1.22 x 10(-4)). The strongest association with FEV1/FVC ratio was observed with ABCC1 (P = 4.38 x 10(-4)), and ESR1 (P = 5.42 x 10(-4)) among ever-smokers. Conclusions: Polymorphisms spanning previously associated lung function genes did not show strong evidence for association with lung function measures in the SpiroMeta consortium population. Common SERPINA1 polymorphisms may affect FEV1 among smokers in the general population.

Published
2011
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29. A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample

Author

University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Department of Public Health, Obeidat, Ma'en, Wain, Louise V., Shrine, Nick, Kalsheker, Noor, Artigas, Maria Soler, Repapi, Emmanouela, Burton, Paul R., Johnson, Toby, Ramasamy, Adaikalavan, Zhao, Jing Hua, Zhai, Guangju, Huffman, Jennifer E., Vitart, Veronique, Albrecht, Eva, Igl, Wilmar, Hartikainen, Anna-Liisa, Pouta, Anneli, Cadby, Gemma, Hui, Jennie, Palmer, Lyle J., Hadley, David, McArdle, Wendy L., Rudnicka, Alicja R., Barroso, Ines, Loos, Ruth J. F., Wareham, Nicholas J., Mangino, Massimo, Soranzo, Nicole, Spector, Tim D., Glaeser, Sven, Homuth, Georg, Voelzke, Henry, Deloukas, Panos, Granell, Raquel, Henderson, John, Grkovic, Ivica, Jankovic, Stipan, Zgaga, Lina, Polasek, Ozren, Rudan, Igor, Wright, Alan F., Campbell, Harry, Wild, Sarah H., Wilson, James F., Heinrich, Joachim, Imboden, Medea, Probst-Hensch, Nicole M., Gyllensten, Ulf, Johansson, Asa, Zaboli, Ghazal, Mustelin, Linda, Rantanen, Taina, Surakka, Ida, Kaprio, Jaakko, Jarvelin, Marjo-Riitta, Hayward, Caroline, Evans, David M., Koch, Beate, Musk, Arthur William, Elliott, Paul, Strachan, David P., Tobin, Martin D., Sayers, Ian, Hall, Ian P., SpiroMeta Consortium, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Department of Public Health, Obeidat, Ma'en, Wain, Louise V., Shrine, Nick, Kalsheker, Noor, Artigas, Maria Soler, Repapi, Emmanouela, Burton, Paul R., Johnson, Toby, Ramasamy, Adaikalavan, Zhao, Jing Hua, Zhai, Guangju, Huffman, Jennifer E., Vitart, Veronique, Albrecht, Eva, Igl, Wilmar, Hartikainen, Anna-Liisa, Pouta, Anneli, Cadby, Gemma, Hui, Jennie, Palmer, Lyle J., Hadley, David, McArdle, Wendy L., Rudnicka, Alicja R., Barroso, Ines, Loos, Ruth J. F., Wareham, Nicholas J., Mangino, Massimo, Soranzo, Nicole, Spector, Tim D., Glaeser, Sven, Homuth, Georg, Voelzke, Henry, Deloukas, Panos, Granell, Raquel, Henderson, John, Grkovic, Ivica, Jankovic, Stipan, Zgaga, Lina, Polasek, Ozren, Rudan, Igor, Wright, Alan F., Campbell, Harry, Wild, Sarah H., Wilson, James F., Heinrich, Joachim, Imboden, Medea, Probst-Hensch, Nicole M., Gyllensten, Ulf, Johansson, Asa, Zaboli, Ghazal, Mustelin, Linda, Rantanen, Taina, Surakka, Ida, Kaprio, Jaakko, Jarvelin, Marjo-Riitta, Hayward, Caroline, Evans, David M., Koch, Beate, Musk, Arthur William, Elliott, Paul, Strachan, David P., Tobin, Martin D., Sayers, Ian, Hall, Ian P., and SpiroMeta Consortium

Abstract

RATIONALE: Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium). OBJECTIVES: To comprehensively analyse previously reported genetic associations with lung function measures, and to investigate whether single nucleotide polymorphisms (SNPs) in these genomic regions are associated with lung function in a large population sample. METHODS: We analysed association for SNPs tagging 130 genes and 48 intergenic regions (+/-10 kb), after conducting a systematic review of the literature in the PubMed database for genetic association studies reporting lung function associations. RESULTS: The analysis included 16,936 genotyped and imputed SNPs. No loci showed overall significant association for FEV(1) or FEV(1)/FVC traits using a carefully defined significance threshold of 1.3×10(-5). The most significant loci associated with FEV(1) include SNPs tagging MACROD2 (P = 6.81×10(-5)), CNTN5 (P = 4.37×10(-4)), and TRPV4 (P = 1.58×10(-3)). Among ever-smokers, SERPINA1 showed the most significant association with FEV(1) (P = 8.41×10(-5)), followed by PDE4D (P = 1.22×10(-4)). The strongest association with FEV(1)/FVC ratio was observed with ABCC1 (P = 4.38×10(-4)), and ESR1 (P = 5.42×10(-4)) among ever-smokers. CONCLUSIONS: Polymorphisms spanning previously associated lung function genes did not show strong evidence for association with lung function measures in the SpiroMeta consortium population. Common SERPINA1 polymorphisms may affect FEV(1) among smokers in the general population.

Published
2011

30. Genome-wide association study identifies five loci associated with lung function

Author

Repapi, Emmanouela, Sayers, Ian, Wain, Louise V., Burton, Paul R., Johnson, Toby, Obeidat, Ma'en, Zhao, Jing Hua, Ramasamy, Adaikalavan, Zhai, Guangju, Vitart, Veronique, Huffman, Jennifer E., Igl, Wilmar, Albrecht, Eva, Deloukas, Panos, Henderson, John, Granell, Raquel, McArdle, Wendy L., Rudnicka, Alicja R., Barroso, Ines, Loos, Ruth J. F., Wareham, Nicholas J., Mustelin, Linda, Rantanen, Taina, Surakka, Ida, Imboden, Medea, Wichmann, H. Erich, Grkovic, Ivica, Jankovic, Stipan, Zgaga, Lina, Hartikainen, Anna-Liisa, Peltonen, Leena, Gyllensten, Ulf, Johansson, Åsa, Zaboli, Ghazal, Campbell, Harry, Wild, Sarah H., Wilson, James F., Glaeser, Sven, Homuth, Georg, Voelzke, Henry, Mangino, Massimo, Soranzo, Nicole, Spector, Tim D., Polasek, Ozren, Rudan, Igor, Wright, Alan F., Heliovaara, Markku, Ripatti, Samuli, Pouta, Anneli, Naluai, Asa Torinsson, Olin, Anna-Carin, Torén, Kjell, Cooper, Matthew N., James, Alan L., Palmer, Lyle J., Hingorani, Aroon D., Wannamethee, S. Goya, Whincup, Peter H., Smith, George Davey, Ebrahim, Shah, McKeever, Tricia M., Pavord, Ian D., MacLeod, Andrew K., Morris, Andrew D., Porteous, David J., Cooper, Cyrus, Dennison, Elaine, Shaheen, Seif, Karrasch, Stefan, Schnabel, Eva, Schulz, Holger, Grallert, Harald, Bouatia-Naji, Nabila, Delplanque, Jerome, Froguel, Philippe, Blakey, John D., Britton, John R., Morris, Richard W., Holloway, John W., Lawlor, Debbie A., Hui, Jennie, Nyberg, Fredrik, Jarvelin, Marjo-Riitta, Jackson, Cathy, Kahonen, Mika, Kaprio, Jaakko, Probst-Hensch, Nicole M., Koch, Beate, Hayward, Caroline, Evans, David M., Elliott, Paul, Strachan, David P., Hall, Ian P., Tobin, Martin D., Repapi, Emmanouela, Sayers, Ian, Wain, Louise V., Burton, Paul R., Johnson, Toby, Obeidat, Ma'en, Zhao, Jing Hua, Ramasamy, Adaikalavan, Zhai, Guangju, Vitart, Veronique, Huffman, Jennifer E., Igl, Wilmar, Albrecht, Eva, Deloukas, Panos, Henderson, John, Granell, Raquel, McArdle, Wendy L., Rudnicka, Alicja R., Barroso, Ines, Loos, Ruth J. F., Wareham, Nicholas J., Mustelin, Linda, Rantanen, Taina, Surakka, Ida, Imboden, Medea, Wichmann, H. Erich, Grkovic, Ivica, Jankovic, Stipan, Zgaga, Lina, Hartikainen, Anna-Liisa, Peltonen, Leena, Gyllensten, Ulf, Johansson, Åsa, Zaboli, Ghazal, Campbell, Harry, Wild, Sarah H., Wilson, James F., Glaeser, Sven, Homuth, Georg, Voelzke, Henry, Mangino, Massimo, Soranzo, Nicole, Spector, Tim D., Polasek, Ozren, Rudan, Igor, Wright, Alan F., Heliovaara, Markku, Ripatti, Samuli, Pouta, Anneli, Naluai, Asa Torinsson, Olin, Anna-Carin, Torén, Kjell, Cooper, Matthew N., James, Alan L., Palmer, Lyle J., Hingorani, Aroon D., Wannamethee, S. Goya, Whincup, Peter H., Smith, George Davey, Ebrahim, Shah, McKeever, Tricia M., Pavord, Ian D., MacLeod, Andrew K., Morris, Andrew D., Porteous, David J., Cooper, Cyrus, Dennison, Elaine, Shaheen, Seif, Karrasch, Stefan, Schnabel, Eva, Schulz, Holger, Grallert, Harald, Bouatia-Naji, Nabila, Delplanque, Jerome, Froguel, Philippe, Blakey, John D., Britton, John R., Morris, Richard W., Holloway, John W., Lawlor, Debbie A., Hui, Jennie, Nyberg, Fredrik, Jarvelin, Marjo-Riitta, Jackson, Cathy, Kahonen, Mika, Kaprio, Jaakko, Probst-Hensch, Nicole M., Koch, Beate, Hayward, Caroline, Evans, David M., Elliott, Paul, Strachan, David P., Hall, Ian P., and Tobin, Martin D.

Abstract

Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n ≤ 32,184 additional individuals) and in silico summary association data from the CHARGE Consortium (n = 21,209) and the Health 2000 survey (n ≤ 883). We confirmed the reported locus at 4q31 and identified associations with FEV1 or FEV1/FVC and common variants at five additional loci: 2q35 in TNS1 (P = 1.11 × 10−12), 4q24 in GSTCD (2.18 × 10−23), 5q33 in HTR4 (P = 4.29 × 10−9), 6p21 in AGER (P = 3.07 × 10−15) and 15q23 in THSD4 (P = 7.24 × 10−15). mRNA analyses showed expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in human lung tissue. These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.

Published
2010
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32. A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample

Author

Obeidat, Ma'en, primary, Wain, Louise V., additional, Shrine, Nick, additional, Kalsheker, Noor, additional, Artigas, Maria Soler, additional, Repapi, Emmanouela, additional, Burton, Paul R., additional, Johnson, Toby, additional, Ramasamy, Adaikalavan, additional, Zhao, Jing Hua, additional, Zhai, Guangju, additional, Huffman, Jennifer E., additional, Vitart, Veronique, additional, Albrecht, Eva, additional, Igl, Wilmar, additional, Hartikainen, Anna-Liisa, additional, Pouta, Anneli, additional, Cadby, Gemma, additional, Hui, Jennie, additional, Palmer, Lyle J., additional, Hadley, David, additional, McArdle, Wendy L., additional, Rudnicka, Alicja R., additional, Barroso, Inês, additional, Loos, Ruth J. F., additional, Wareham, Nicholas J., additional, Mangino, Massimo, additional, Soranzo, Nicole, additional, Spector, Tim D., additional, Gläser, Sven, additional, Homuth, Georg, additional, Völzke, Henry, additional, Deloukas, Panos, additional, Granell, Raquel, additional, Henderson, John, additional, Grkovic, Ivica, additional, Jankovic, Stipan, additional, Zgaga, Lina, additional, Polašek, Ozren, additional, Rudan, Igor, additional, Wright, Alan F., additional, Campbell, Harry, additional, Wild, Sarah H., additional, Wilson, James F., additional, Heinrich, Joachim, additional, Imboden, Medea, additional, Probst-Hensch, Nicole M., additional, Gyllensten, Ulf, additional, Johansson, Åsa, additional, Zaboli, Ghazal, additional, Mustelin, Linda, additional, Rantanen, Taina, additional, Surakka, Ida, additional, Kaprio, Jaakko, additional, Jarvelin, Marjo-Riitta, additional, Hayward, Caroline, additional, Evans, David M., additional, Koch, Beate, additional, Musk, Arthur William, additional, Elliott, Paul, additional, Strachan, David P., additional, Tobin, Martin D., additional, Sayers, Ian, additional, Hall, Ian P., additional, and Consortium, SpiroMeta, additional

Published
2011
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38. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

Author

Soler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Zhao JH, Smith AV, Huffman JE, Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, Lopez LM, Johnson T, Aldrich MC, Aspelund T, Barroso I, Campbell H, Cassano PA, Couper DJ, Eiriksdottir G, Franceschini N, Garcia M, Gieger C, Gislason GK, Grkovic I, Hammond CJ, Hancock DB, Harris TB, Ramasamy A, Heckbert SR, Heliövaara M, Homuth G, Hysi PG, James AL, Jankovic S, Joubert BR, Karrasch S, Klopp N, Koch B, Kritchevsky SB, Launer LJ, Liu Y, Loehr LR, Lohman K, Loos RJ, Lumley T, Al Balushi KA, Ang WQ, Barr RG, Beilby J, Blakey JD, Boban M, Boraska V, Brisman J, Britton JR, Brusselle GG, Cooper C, Curjuric I, Dahgam S, Deary IJ, Ebrahim S, Eijgelsheim M, Francks C, Gaysina D, Granell R, Gu X, Hankinson JL, Hardy R, Harris SE, Henderson J, Henry A, Hingorani AD, Hofman A, Holt PG, Hui J, Hunter ML, Imboden M, Jameson KA, Kerr SM, Kolcic I, Kronenberg F, Liu JZ, Marchini J, McKeever T, Morris AD, Olin AC, Porteous DJ, Postma DS, Rich SS, Ring SM, Rivadeneira F, Rochat T, Sayer AA, Sayers I, Sly PD, Smith GD, Sood A, Starr JM, Uitterlinden AG, Vonk JM, Wannamethee SG, Whincup PH, Wijmenga C, Williams OD, Wong A, Mangino M, Marciante KD, McArdle WL, Meibohm B, Morrison AC, North KE, Omenaas E, Palmer LJ, Pietiläinen KH, Pin I, Pola Sbreve Ek O, Pouta A, Psaty BM, Hartikainen AL, Rantanen T, Ripatti S, Rotter JI, Rudan I, Rudnicka AR, Schulz H, Shin SY, Spector TD, Surakka I, Vitart V, Völzke H, Wareham NJ, Warrington NM, Wichmann HE, Wild SH, Wilk JB, Wjst M, Wright AF, Zgaga L, Zemunik T, Pennell CE, Nyberg F, Kuh D, Holloway JW, Boezen HM, Lawlor DA, Morris RW, Probst-Hensch N, Kaprio J, Wilson JF, Hayward C, Kähönen M, Heinrich J, Musk AW, Jarvis DL, Gläser S, Järvelin MR, Ch Stricker BH, Elliott P, O'Connor GT, Strachan DP, London SJ, Hall IP, Gudnason V, and Tobin MD

Subjects
Child, Humans, Pulmonary Disease, Chronic Obstructive genetics, Pulmonary Disease, Chronic Obstructive physiopathology, White People, Genome-Wide Association Study, Respiratory Function Tests
Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10(-8)) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

Published
2011
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39. New paradigm in training of undergraduate clinical skills: the NEPTUNE-CS project at the Split University School of Medicine.

Author

Simunovic VJ, Hozo I, Rakic M, Jukic M, Tomic S, Kokic S, Ljutic D, Druzijanic N, Grkovic I, Simunovic F, and Marasovic D

Subjects
Croatia, Curriculum, Humans, Organizational Case Studies, Clinical Competence, Diffusion of Innovation, Education, Medical, Undergraduate methods
Abstract

Clinical skills' training is arguably the weakest point in medical schools' curriculum. This study briefly describes how we at the Split University School of Medicine cope with this problem. We consider that, over the last decades, a considerable advancement in teaching methodologies, tools, and assessment of students has been made. However, there are many unresolved issues, most notably: (i) the institutional value system, impeding the motivation of the teaching staff; (ii) lack of a strong mentoring system; (iii) organization, timing, and placement of training in the curriculum; (iv) lack of publications pertinent to training; and (v) unwillingness of patients to participate in student training. To improve the existing training models we suggest increased institutional awareness of obstacles, as well as willingness to develop mechanisms for increasing the motivation of faculty. It is necessary to introduce changes in the structure and timing of training and to complement it with a catalog, practicum, and portfolio of clinical skills. At Split University School of Medicine, we developed a new paradigm aimed to improve the teaching of clinical skills called "Neptune-CSS," which stands for New Paradigm in Training of Undergraduate Clinical Skills in Split.

Published
2010
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40. Genome-wide association study identifies five loci associated with lung function.

Author

Repapi E, Sayers I, Wain LV, Burton PR, Johnson T, Obeidat M, Zhao JH, Ramasamy A, Zhai G, Vitart V, Huffman JE, Igl W, Albrecht E, Deloukas P, Henderson J, Granell R, McArdle WL, Rudnicka AR, Barroso I, Loos RJ, Wareham NJ, Mustelin L, Rantanen T, Surakka I, Imboden M, Wichmann HE, Grkovic I, Jankovic S, Zgaga L, Hartikainen AL, Peltonen L, Gyllensten U, Johansson A, Zaboli G, Campbell H, Wild SH, Wilson JF, Gläser S, Homuth G, Völzke H, Mangino M, Soranzo N, Spector TD, Polasek O, Rudan I, Wright AF, Heliövaara M, Ripatti S, Pouta A, Naluai AT, Olin AC, Torén K, Cooper MN, James AL, Palmer LJ, Hingorani AD, Wannamethee SG, Whincup PH, Smith GD, Ebrahim S, McKeever TM, Pavord ID, MacLeod AK, Morris AD, Porteous DJ, Cooper C, Dennison E, Shaheen S, Karrasch S, Schnabel E, Schulz H, Grallert H, Bouatia-Naji N, Delplanque J, Froguel P, Blakey JD, Britton JR, Morris RW, Holloway JW, Lawlor DA, Hui J, Nyberg F, Jarvelin MR, Jackson C, Kähönen M, Kaprio J, Probst-Hensch NM, Koch B, Hayward C, Evans DM, Elliott P, Strachan DP, Hall IP, and Tobin MD

Subjects
Female, Forced Expiratory Volume, Glutathione Transferase genetics, Humans, Lung metabolism, Lung physiopathology, Male, Meta-Analysis as Topic, Microfilament Proteins genetics, Polymorphism, Single Nucleotide, Pulmonary Disease, Chronic Obstructive genetics, Pulmonary Disease, Chronic Obstructive physiopathology, RNA, Messenger genetics, RNA, Messenger metabolism, Receptor for Advanced Glycation End Products, Receptors, Immunologic genetics, Receptors, Serotonin, 5-HT4 genetics, Respiratory Function Tests, Spirometry, Tensins, Thrombospondins genetics, Vital Capacity, Gene Expression Profiling, Genome, Human genetics, Genome-Wide Association Study methods, Lung physiology
Abstract

Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n < or = 32,184 additional individuals) and in silico summary association data from the CHARGE Consortium (n = 21,209) and the Health 2000 survey (n < or = 883). We confirmed the reported locus at 4q31 and identified associations with FEV(1) or FEV(1)/FVC and common variants at five additional loci: 2q35 in TNS1 (P = 1.11 x 10(-12)), 4q24 in GSTCD (2.18 x 10(-23)), 5q33 in HTR4 (P = 4.29 x 10(-9)), 6p21 in AGER (P = 3.07 x 10(-15)) and 15q23 in THSD4 (P = 7.24 x 10(-15)). mRNA analyses showed expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in human lung tissue. These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.

Published
2010
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