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2. Decreasing Photoreactivity and Concurrent Change in Dissolved Organic Matter Composition With Increasing Inland Water Residence Time

Author

European Commission, 0000-0002-3251-7974, 0000-0002-2433-4190, 0000-0003-3509-8266, 0000-0003-4505-4224, 0000-0003-0664-2242, 0000-0002-6503-9497, Grasset, C., Einarsdottir, K., Catalán, N., Tranvik, L. J., Groeneveld, M., Hawkes, J. A., Attermeyer, K., European Commission, 0000-0002-3251-7974, 0000-0002-2433-4190, 0000-0003-3509-8266, 0000-0003-4505-4224, 0000-0003-0664-2242, 0000-0002-6503-9497, Grasset, C., Einarsdottir, K., Catalán, N., Tranvik, L. J., Groeneveld, M., Hawkes, J. A., and Attermeyer, K.

Abstract

Photochemical degradation of dissolved organic matter (DOM) has been the subject of numerous studies; however, its regulation along the inland water continuum is still unclear. We aimed to unravel the DOM photoreactivity and concurrent DOM compositional changes across 30 boreal aquatic ecosystems including peat waters, streams, rivers, and lakes distributed along a water residence time (WRT) gradient. Samples were subjected to a standardized exposure of simulated sunlight. We measured the apparent quantum yield (AQY), which corresponds to DOM photomineralization per photon absorbed, and the compositional change in DOM at bulk and individual compound levels in the original samples and after irradiation. AQY increased with the abundance of terrestrially derived DOM and decreased at higher WRT. Additionally, the photochemical changes in both DOM optical properties and molecular composition resembled changes along the natural boreal WRT gradient at low WRT (<3 years). Accordingly, mass spectrometry revealed that the abundance of photolabile and photoproduced molecules decreased with WRT along the boreal aquatic continuum. Our study highlights the tight link between DOM composition and DOM photodegradation. We suggest that photodegradation is an important driver of DOM composition change in waters with low WRT, where DOM is highly photoreactive.

Published
2024

3. Decreasing Photoreactivity and Concurrent Change in Dissolved Organic Matter Composition With Increasing Inland Water Residence Time.

Author

Grasset, C., Einarsdottir, K., Catalán, N., Tranvik, L. J., Groeneveld, M., Hawkes, J. A., and Attermeyer, K.

Subjects
DISSOLVED organic matter, PHOTODEGRADATION, OPTICAL properties, MASS spectrometry
Abstract

Photochemical degradation of dissolved organic matter (DOM) has been the subject of numerous studies; however, its regulation along the inland water continuum is still unclear. We aimed to unravel the DOM photoreactivity and concurrent DOM compositional changes across 30 boreal aquatic ecosystems including peat waters, streams, rivers, and lakes distributed along a water residence time (WRT) gradient. Samples were subjected to a standardized exposure of simulated sunlight. We measured the apparent quantum yield (AQY), which corresponds to DOM photomineralization per photon absorbed, and the compositional change in DOM at bulk and individual compound levels in the original samples and after irradiation. AQY increased with the abundance of terrestrially derived DOM and decreased at higher WRT. Additionally, the photochemical changes in both DOM optical properties and molecular composition resembled changes along the natural boreal WRT gradient at low WRT (<3 years). Accordingly, mass spectrometry revealed that the abundance of photolabile and photoproduced molecules decreased with WRT along the boreal aquatic continuum. Our study highlights the tight link between DOM composition and DOM photodegradation. We suggest that photodegradation is an important driver of DOM composition change in waters with low WRT, where DOM is highly photoreactive. Key Points: Dissolved organic matter (DOM) photoreactivity decreased with increasing water residence time (WRT)The photochemical changes in both DOM optical properties and molecular composition resembled changes along the aquatic continuum at low WRTPhotodegradation is a potentially important driver of change in DOM composition in waters with low WRT [ABSTRACT FROM AUTHOR]

Published
2024
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5. Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study

Author

Kloss, P, Lindholz, M, Milnik, A, Azoulay, E, Cecconi, M, Citerio, G, De Corte, T, Duska, F, Galarza, L, Greco, M, Girbes, A, Kesecioglu, J, Mellinghoff, J, Ostermann, M, Pellegrini, M, Teboul, J, De Waele, J, Wong, A, Schaller, S, Aires, B, Gira, A, Eller, P, Hamid, T, Haque, I, De Buyser, W, Cudia, A, De Backer, D, Foulon, P, Collin, V, Van Hecke, J, De Waele, E, Van Malderen, C, Mesland, J, Biston, P, Piagnerelli, M, Haentjens, L, De Schryver, N, Van Leemput, J, Vanhove, P, Bulpa, P, Ilieva, V, Katz, D, Binnie, A, Geagea, A, Tirapegui, F, Lago, G, Graf, J, Perez-Araos, R, Vargas, P, Martinez, F, Labarca, E, Franco, D, Parra-Tanoux, D, Yepes, D, Hammouda, A, Elmandouh, O, Azzam, A, Hussein, A, Galal, I, Awad, A, Azab, M, Abdalla, M, Assal, H, Alfishawy, M, Ghozy, S, Tharwat, S, Eldaly, A, Ellervee, A, Reinhard, V, Chrisment, A, Poyat, C, Badie, J, Berdaguer Ferrari, F, Weiss, B, Schellenberg, C, Grunow, J, Lorenz, M, Spieth, P, Bota, M, Fichtner, F, Fuest, K, Lahmer, T, Herrmann, J, Meybohm, P, Markou, N, Vasileiadou, G, Chrysanthopoulou, E, Papamichalis, P, Soultati, I, Jog, S, Kalvit, K, Nainan Myatra, S, Krupa, I, Tharwat, A, Nichol, A, Mccarthy, A, Mahmoodpoor, A, Tonetti, T, Isoni, P, Spadaro, S, Volta, C, Mirabella, L, Noto, A, Florio, G, Guzzardella, A, Paleari, C, Baccanelli, F, Savi, M, Antonelli, M, De Pascale, G, Vaccarini, B, Montrucchio, G, Sales, G, Donadello, K, Gottin, L, Nizzero, M, Polati, E, De Rosa, S, Sulemanji, D, Abusalama, A, Elhadi, M, Jesus, M, Gonzalez, D, Robles, V, Canedo, N, Chavez, A, Dendane, T, Grady, B, de Jong, B, van der Heiden, E, Thoral, P, van den Bogaard, B, Spronk, P, Achterberg, S, Groeneveld, M, So, R, de Wijs, C, Scholten, H, Beishuizen, A, Cornet, A, Reidinga, A, Kranen, H, Mensink, R, den Boer, S, de Groot, M, Beck, O, Bethlehem, C, van Bussel, B, Frenzel, T, de Jong, C, Wilting, R, Mehagnoul-Schipper, J, Alasia, D, Kumar, A, Qayyum, A, Rana, M, Jayyab, M, Sierra, R, Hernandez, A, Taborda, L, Anselmo, M, Ramires, T, Silva, C, Roriz, C, Morais, R, Póvoa, P, Patricio, P, Pinto, A, Santos, M, Costa, V, Cunha, P, Gonçalves, C, Nunes, S, Camões, J, Adrião, D, Oliveira, A, Omrani, A, Maslamani, M, Elbuzidi, A, Qudah, B, Akkari, A, Alkhatteb, M, Baiou, A, Husain, A, Alwraidat, M, Saif, I, Bakdach, D, Ahmed, A, Aleef, M, Bintaher, A, Petrisor, C, Popov, E, Popova, K, Dementienko, M, Teplykh, B, Pyregov, A, Davydova, L, Vladislav, B, Neporada, E, Zverev, I, Meshchaninova, S, Sokolov, D, Gavrilova, E, Shlyk, I, Poliakov, I, Vlasova, M, Aljuhani, O, Alkhalaf, A, Humaid, F, Arabi, Y, Kuhail, A, Elrabi, O, Ghannam, M, Kansal, A, Ho, V, Ng, J, García, R, Fraga, X, del Pilar García-Bonillo, M, Padilla-Serrano, A, Cuadrado, M, Ferrando, C, Catalan-Monzon, I, Frutos-Vivar, F, Jimenez, J, Rodríguez-Solis, C, Franquesa-Gonzalez, E, Acosta, G, Cabrera, L, Parra, J, Gonzalez, F, del Carmen Conesa, M, Varela, I, Pravia, O, Delgado, M, de Cabo, C, Ioan, A, Perez-Calvo, C, Santos, A, Abad-Motos, A, Ripolles-Melchor, J, Martin, B, Teruel, S, Lucas, J, Ortiz, A, de Pablo Sánchez, R, Barrueco-Francioni, J, Espina, L, Bonell-Goytisolo, J, Salaverria, I, Mir, A, Rodriguez-Ruiz, E, Valverde, V, Cubero, P, Linde, F, Leganes, N, Romeu, J, Concha, P, Berezo-Garcia, J, Fraile, V, Cuenca-Rubio, C, Pérez-Torres, D, Serrano, A, Valero, C, Suner, A, Larrañaga, L, Legaristi, N, Ferrigno, G, Khlafalla, S, Bihariesingh-Sanchit, R, Zoerner, F, Grip, J, Kilsand, K, Mårtensson, J, Österlind, J, von Seth, M, Berkius, J, Ceruti, S, Glotta, A, Izdes, S, Turan, I, Cosar, A, Halacli, B, Dereli, N, Yilmaz, M, Akbas, T, Elay, G, Eyüpoğlu, S, Bílír, Y, Saraçoğlu, K, Kaya, E, Sahin, A, Ekren, P, Mengi, T, Suner, K, Tomak, Y, Eroglu, A, Alsabbah, A, Hanlon, K, Gervin, K, Mcmahon, S, Hagan, S, Higenbottam, C, Mullhi, R, Poulton, L, Torlinski, T, Gareth, A, Truman, N, Vijayakumar, G, Hall, C, Jubb, A, Cagova, L, Jones, N, Graham, S, Robin, N, Cowton, A, Donnelly, A, Singatullina, N, Kent, M, Boulanger, C, Campbell, Z, Potter, E, Duric, N, Szakmany, T, Kviatkovske, O, Marczin, N, Ellis, C, Saha, R, Sri-Chandana, C, Allan, J, Mumelj, L, Venkatesh, H, Gotz, V, Cochrane, A, Ficial, B, Kamble, S, Lumlertgul, N, Oddy, C, Jain, S, Crapelli, G, Vlachou, A, Golden, D, Garrioch, S, Henning, J, Loveleena, G, Davey, M, Grauslyte, L, Salciute-Simene, E, Cook, M, Barling, D, Broadhurst, P, Purvis, S, Spivey, M, Shuker, B, Grecu, I, Harding, D, Dean, J, Nielsen, N, Al-Bayati, S, Al-Sadawi, M, Charron, M, Stubenrauch, P, Santanilla, J, Wentowski, C, Rosenberger, D, Eksarko, P, Jawa, R, Kloss, Philipp, Lindholz, Maximilian, Milnik, Annette, Azoulay, Elie, Cecconi, Maurizio, Citerio, Giuseppe, De Corte, Thomas, Duska, Frantisek, Galarza, Laura, Greco, Massimiliano, Girbes, Armand R. J., Kesecioglu, Jozef, Mellinghoff, Johannes, Ostermann, Marlies, Pellegrini, Mariangela, Teboul, Jean-Louis, De Waele, Jan, Wong, Adrian, Schaller, Stefan J., Aires, Buenos, Gira, Alicia, Eller, Philipp, Hamid, Tarikul, Haque, Injamam Ull, De Buyser, Wim, Cudia, Antonella, De Backer, Daniel, Foulon, Pierre, Collin, Vincent, Van Hecke, Jolien, De Waele, Elisabeth, Van Malderen, Claire, Mesland, Jean-Baptiste, Biston, Patrick, Piagnerelli, Michael, Haentjens, Lionel, De Schryver, Nicolas, Van Leemput, Jan, Vanhove, Philippe, Bulpa, Pierre, Ilieva, Viktoria, Katz, David, Binnie, Alexandra, Geagea, Anna, Tirapegui, Fernando, Lago, Gustavo, Graf, Jerónimo, Perez-Araos, Rodrigo, Vargas, Patricio, Martinez, Felipe, Labarca, Eduardo, Franco, Daniel Molano, Parra-Tanoux, Daniela, Yepes, David, Hammouda, Ahmed, Elmandouh, Omar, Azzam, Ahmed, Hussein, Aliae Mohamed, Galal, Islam, Awad, Ahmed K., Azab, Mohammed A., Abdalla, Maged, Assal, Hebatallah, Alfishawy, Mostafa, Ghozy, Sherief, Tharwat, Samar, Eldaly, Abdullah, Ellervee, Anneli, Reinhard, Veronika, Chrisment, Anne, Poyat, Chrystelle, Badie, Julio, Berdaguer Ferrari, Fernando, Weiss, Björn, Schellenberg, Clara, Grunow, Julius J, Lorenz, Marco, Schaller, Stefan J, Spieth, Peter, Bota, Marc, Fichtner, Falk, Fuest, Kristina, Lahmer, Tobias, Herrmann, Johannes, Meybohm, Patrick, Markou, Nikolaos, Vasileiadou, Georgia, Chrysanthopoulou, Evangelia, Papamichalis, Panagiotis, Soultati, Ioanna, Jog, Sameer, Kalvit, Kushal, Nainan Myatra, Sheila, Krupa, Ivan, Tharwat, Aisa, Nichol, Alistair, McCarthy, Aine, Mahmoodpoor, Ata, Tonetti, Tommaso, Isoni, Paolo, Spadaro, Savino, Volta, Carlo Alberto, Mirabella, Lucia, Noto, Alberto, Florio, Gaetano, Guzzardella, Amedeo, Paleari, Chiara, Baccanelli, Federica, Savi, Marzia, Antonelli, Massimo, De Pascale, Gennaro, Vaccarini, Barbara, Montrucchio, Giorgia, Sales, Gabriele, Donadello, Katia, Gottin, Leonardo, Nizzero, Marta, Polati, Enrico, De Rosa, Silvia, Sulemanji, Demet, Abusalama, Abdurraouf, Elhadi, Muhammed, Jesus, Montelongo Felipe De, Gonzalez, Daniel Rodriguez, Robles, Victor Hugo Madrigal, Canedo, Nancy, Chavez, Alejandro Esquivel, Dendane, Tarek, Grady, Bart, de Jong, Ben, van der Heiden, Eveline, Thoral, Patrick, van den Bogaard, Bas, Spronk, Peter E., Achterberg, Sefanja, Groeneveld, Melanie, So, Ralph K. L., de Wijs, Calvin, Scholten, Harm, Beishuizen, Albertus, Cornet, Alexander D., Reidinga, Auke C., Kranen, Hetty, Mensink, Roos, den Boer, Sylvia, de Groot, Marcel, Beck, Oliver, Bethlehem, Carina, van Bussel, Bas, Frenzel, Tim, de Jong, Celestine, Wilting, Rob, Mehagnoul-Schipper, Jannet, Alasia, Datonye, Kumar, Ashok, Qayyum, Ahad, Rana, Muhammad, Jayyab, Mustafa Abu, Sierra, Rosario Quispe, Hernandez, Aaron Mark, Taborda, Lúcia, Anselmo, Mónica, Ramires, Tiago, Silva, Catarina, Roriz, Carolina, Morais, Rui, Póvoa, Pedro, Patricio, Patricia, Pinto, André, Santos, Maria Lurdes, Costa, Vasco, Cunha, Pedro, Gonçalves, Celina, Nunes, Sandra, Camões, João, Adrião, Diana, Oliveira, Ana, Omrani, Ali, Maslamani, Muna Al, elbuzidi, Abdurrahmaan Suei, qudah, Bara Mahmoud Al, Akkari, Abdel Rauof, Alkhatteb, Mohamed, Baiou, Anas, Husain, Ahmed, Alwraidat, Mohamed, Saif, Ibrahim Abdulsalam, Bakdach, Dana, Ahmed, Amna, Aleef, Mohamed, Bintaher, Awadh, Petrisor, Cristina, Popov, Evgeniy, Popova, Ksenia, Dementienko, Mariia, Teplykh, Boris, Pyregov, Alexey, Davydova, Liubov, Vladislav, Belskii, Neporada, Elena, Zverev, Ivan, Meshchaninova, Svetlana, Sokolov, Dmitry, Gavrilova, Elena, Shlyk, Irina, Poliakov, Igor, Vlasova, Marina, Aljuhani, Ohoud, Alkhalaf, Amina, Humaid, Felwa Bin, Arabi, Yaseen, Kuhail, Ahmed, Elrabi, Omar, Ghannam, Madihah E., Kansal, Amit, Ho, Vui Kian, Ng, Jensen, García, Raquel Rodrígez, Fraga, Xiana Taboada, del Pilar García-Bonillo, Ma, Padilla-Serrano, Antonio, Cuadrado, Marta Martin, Ferrando, Carlos, Catalan-Monzon, Ignacio, Frutos-Vivar, Fernando, Jimenez, Jorge, Rodríguez-Solis, Carmen, Franquesa-Gonzalez, Enric, Acosta, Guillermo Pérez, Cabrera, Luciano Santana, Parra, Juan Pablo Aviles, Gonzalez, Francisco Muñoyerro, del Carmen Conesa, Maria Lorente, Varela, Ignacio Yago Martinez, Pravia, Orville Victoriano Baez, Delgado, Maria Cruz Martin, de Cabo, Carlos Munoz, Ioan, Ana-Maria, Perez-Calvo, Cesar, Santos, Arnoldo, Abad-Motos, Ane, Ripolles-Melchor, Javier, Martin, Belén Civantos, Teruel, Santiago Yus, Lucas, Juan Higuera, Ortiz, Aaron Blandino, de Pablo Sánchez, Raúl, Barrueco-Francioni, Jesús Emilio, Espina, Lorena Forcelledo, Bonell-Goytisolo, José M., Salaverria, Iñigo, Mir, Antonia Socias, Rodriguez-Ruiz, Emilio, Valverde, Virginia Hidalgo, Cubero, Patricia Jimeno, Linde, Francisca Arbol, Leganes, Nieves Cruza, Romeu, Juan Maria, Concha, Pablo, Berezo-Garcia, José Angel, Fraile, Virginia, Cuenca-Rubio, Cristina, Pérez-Torres, David, Serrano, Ainhoa, Valero, Clara Martínez, Suner, Andrea Ortiz, Larrañaga, Leire, Legaristi, Noemi, Ferrigno, Gerardo, Khlafalla, Safa, Bihariesingh-Sanchit, Rosita, Zoerner, Frank, Grip, Jonathan, Kilsand, Kristina, Mårtensson, Johan, Österlind, Jonas, von Seth, Magnus, Berkius, Johan, Ceruti, Samuele, Glotta, Andrea, Izdes, Seval, Turan, Işıl Özkoçak, Cosar, Ahmet, Halacli, Burcin, Dereli, Necla, Yilmaz, Mehmet, Akbas, Türkay, Elay, Gülseren, Eyüpoğlu, Selin, Bílír, Yelíz, Saraçoğlu, Kemal Tolga, Kaya, Ebru, Sahin, Ayca Sultan, Ekren, Pervin Korkmaz, Mengi, Tuğçe, Suner, Kezban Ozmen, Tomak, Yakup, Eroglu, Ahmet, Alsabbah, Asad, Hanlon, Katie, Gervin, Kevin, McMahon, Sean, Hagan, Samantha, Higenbottam, Caroline V, Mullhi, Randeep, Poulton, Lottie, Torlinski, Tomasz, Gareth, Allen, Truman, Nick, Vijayakumar, Gopal, Hall, Chris, Jubb, Alasdair, Cagova, Lenka, Jones, Nicola, Graham, Sam, Robin, Nicole, Cowton, Amanda, Donnelly, Adrian, Singatullina, Natalia, Kent, Melanie, Boulanger, Carole, Campbell, Zoë, Potter, Elizabeth, Duric, Natalie, Szakmany, Tamas, Kviatkovske, Orinta, Marczin, Nandor, Ellis, Caroline, Saha, Rajnish, Sri-Chandana, Chunda, Allan, John, Mumelj, Lana, Venkatesh, Harish, Gotz, Vera Nina, Cochrane, Anthony, Ficial, Barbara, Kamble, Shruthi, Lumlertgul, Nuttha, Oddy, Christopher, Jain, Susan, Crapelli, Giulia Beatrice, Vlachou, Aikaterini, Golden, David, Garrioch, Sweyn, Henning, Jeremy, Loveleena, Gupta, Davey, Miriam, Grauslyte, Lina, Salciute-Simene, Erika, Cook, Martin, Barling, Danny, Broadhurst, Phil, Purvis, Sarah, Spivey, Michael, Shuker, Benjamin, Grecu, Irina, Harding, Daniel, Dean, James T., Nielsen, Nathan D., Al-Bayati, Sama, Al-Sadawi, Mohammed, Charron, Mariane, Stubenrauch, Peter, Santanilla, Jairo, Wentowski, Catherine, Rosenberger, Dorothea, Eksarko, Polikseni, Jawa, Randeep, Kloss, P, Lindholz, M, Milnik, A, Azoulay, E, Cecconi, M, Citerio, G, De Corte, T, Duska, F, Galarza, L, Greco, M, Girbes, A, Kesecioglu, J, Mellinghoff, J, Ostermann, M, Pellegrini, M, Teboul, J, De Waele, J, Wong, A, Schaller, S, Aires, B, Gira, A, Eller, P, Hamid, T, Haque, I, De Buyser, W, Cudia, A, De Backer, D, Foulon, P, Collin, V, Van Hecke, J, De Waele, E, Van Malderen, C, Mesland, J, Biston, P, Piagnerelli, M, Haentjens, L, De Schryver, N, Van Leemput, J, Vanhove, P, Bulpa, P, Ilieva, V, Katz, D, Binnie, A, Geagea, A, Tirapegui, F, Lago, G, Graf, J, Perez-Araos, R, Vargas, P, Martinez, F, Labarca, E, Franco, D, Parra-Tanoux, D, Yepes, D, Hammouda, A, Elmandouh, O, Azzam, A, Hussein, A, Galal, I, Awad, A, Azab, M, Abdalla, M, Assal, H, Alfishawy, M, Ghozy, S, Tharwat, S, Eldaly, A, Ellervee, A, Reinhard, V, Chrisment, A, Poyat, C, Badie, J, Berdaguer Ferrari, F, Weiss, B, Schellenberg, C, Grunow, J, Lorenz, M, Spieth, P, Bota, M, Fichtner, F, Fuest, K, Lahmer, T, Herrmann, J, Meybohm, P, Markou, N, Vasileiadou, G, Chrysanthopoulou, E, Papamichalis, P, Soultati, I, Jog, S, Kalvit, K, Nainan Myatra, S, Krupa, I, Tharwat, A, Nichol, A, Mccarthy, A, Mahmoodpoor, A, Tonetti, T, Isoni, P, Spadaro, S, Volta, C, Mirabella, L, Noto, A, Florio, G, Guzzardella, A, Paleari, C, Baccanelli, F, Savi, M, Antonelli, M, De Pascale, G, Vaccarini, B, Montrucchio, G, Sales, G, Donadello, K, Gottin, L, Nizzero, M, Polati, E, De Rosa, S, Sulemanji, D, Abusalama, A, Elhadi, M, Jesus, M, Gonzalez, D, Robles, V, Canedo, N, Chavez, A, Dendane, T, Grady, B, de Jong, B, van der Heiden, E, Thoral, P, van den Bogaard, B, Spronk, P, Achterberg, S, Groeneveld, M, So, R, de Wijs, C, Scholten, H, Beishuizen, A, Cornet, A, Reidinga, A, Kranen, H, Mensink, R, den Boer, S, de Groot, M, Beck, O, Bethlehem, C, van Bussel, B, Frenzel, T, de Jong, C, Wilting, R, Mehagnoul-Schipper, J, Alasia, D, Kumar, A, Qayyum, A, Rana, M, Jayyab, M, Sierra, R, Hernandez, A, Taborda, L, Anselmo, M, Ramires, T, Silva, C, Roriz, C, Morais, R, Póvoa, P, Patricio, P, Pinto, A, Santos, M, Costa, V, Cunha, P, Gonçalves, C, Nunes, S, Camões, J, Adrião, D, Oliveira, A, Omrani, A, Maslamani, M, Elbuzidi, A, Qudah, B, Akkari, A, Alkhatteb, M, Baiou, A, Husain, A, Alwraidat, M, Saif, I, Bakdach, D, Ahmed, A, Aleef, M, Bintaher, A, Petrisor, C, Popov, E, Popova, K, Dementienko, M, Teplykh, B, Pyregov, A, Davydova, L, Vladislav, B, Neporada, E, Zverev, I, Meshchaninova, S, Sokolov, D, Gavrilova, E, Shlyk, I, Poliakov, I, Vlasova, M, Aljuhani, O, Alkhalaf, A, Humaid, F, Arabi, Y, Kuhail, A, Elrabi, O, Ghannam, M, Kansal, A, Ho, V, Ng, J, García, R, Fraga, X, del Pilar García-Bonillo, M, Padilla-Serrano, A, Cuadrado, M, Ferrando, C, Catalan-Monzon, I, Frutos-Vivar, F, Jimenez, J, Rodríguez-Solis, C, Franquesa-Gonzalez, E, Acosta, G, Cabrera, L, Parra, J, Gonzalez, F, del Carmen Conesa, M, Varela, I, Pravia, O, Delgado, M, de Cabo, C, Ioan, A, Perez-Calvo, C, Santos, A, Abad-Motos, A, Ripolles-Melchor, J, Martin, B, Teruel, S, Lucas, J, Ortiz, A, de Pablo Sánchez, R, Barrueco-Francioni, J, Espina, L, Bonell-Goytisolo, J, Salaverria, I, Mir, A, Rodriguez-Ruiz, E, Valverde, V, Cubero, P, Linde, F, Leganes, N, Romeu, J, Concha, P, Berezo-Garcia, J, Fraile, V, Cuenca-Rubio, C, Pérez-Torres, D, Serrano, A, Valero, C, Suner, A, Larrañaga, L, Legaristi, N, Ferrigno, G, Khlafalla, S, Bihariesingh-Sanchit, R, Zoerner, F, Grip, J, Kilsand, K, Mårtensson, J, Österlind, J, von Seth, M, Berkius, J, Ceruti, S, Glotta, A, Izdes, S, Turan, I, Cosar, A, Halacli, B, Dereli, N, Yilmaz, M, Akbas, T, Elay, G, Eyüpoğlu, S, Bílír, Y, Saraçoğlu, K, Kaya, E, Sahin, A, Ekren, P, Mengi, T, Suner, K, Tomak, Y, Eroglu, A, Alsabbah, A, Hanlon, K, Gervin, K, Mcmahon, S, Hagan, S, Higenbottam, C, Mullhi, R, Poulton, L, Torlinski, T, Gareth, A, Truman, N, Vijayakumar, G, Hall, C, Jubb, A, Cagova, L, Jones, N, Graham, S, Robin, N, Cowton, A, Donnelly, A, Singatullina, N, Kent, M, Boulanger, C, Campbell, Z, Potter, E, Duric, N, Szakmany, T, Kviatkovske, O, Marczin, N, Ellis, C, Saha, R, Sri-Chandana, C, Allan, J, Mumelj, L, Venkatesh, H, Gotz, V, Cochrane, A, Ficial, B, Kamble, S, Lumlertgul, N, Oddy, C, Jain, S, Crapelli, G, Vlachou, A, Golden, D, Garrioch, S, Henning, J, Loveleena, G, Davey, M, Grauslyte, L, Salciute-Simene, E, Cook, M, Barling, D, Broadhurst, P, Purvis, S, Spivey, M, Shuker, B, Grecu, I, Harding, D, Dean, J, Nielsen, N, Al-Bayati, S, Al-Sadawi, M, Charron, M, Stubenrauch, P, Santanilla, J, Wentowski, C, Rosenberger, D, Eksarko, P, Jawa, R, Kloss, Philipp, Lindholz, Maximilian, Milnik, Annette, Azoulay, Elie, Cecconi, Maurizio, Citerio, Giuseppe, De Corte, Thomas, Duska, Frantisek, Galarza, Laura, Greco, Massimiliano, Girbes, Armand R. J., Kesecioglu, Jozef, Mellinghoff, Johannes, Ostermann, Marlies, Pellegrini, Mariangela, Teboul, Jean-Louis, De Waele, Jan, Wong, Adrian, Schaller, Stefan J., Aires, Buenos, Gira, Alicia, Eller, Philipp, Hamid, Tarikul, Haque, Injamam Ull, De Buyser, Wim, Cudia, Antonella, De Backer, Daniel, Foulon, Pierre, Collin, Vincent, Van Hecke, Jolien, De Waele, Elisabeth, Van Malderen, Claire, Mesland, Jean-Baptiste, Biston, Patrick, Piagnerelli, Michael, Haentjens, Lionel, De Schryver, Nicolas, Van Leemput, Jan, Vanhove, Philippe, Bulpa, Pierre, Ilieva, Viktoria, Katz, David, Binnie, Alexandra, Geagea, Anna, Tirapegui, Fernando, Lago, Gustavo, Graf, Jerónimo, Perez-Araos, Rodrigo, Vargas, Patricio, Martinez, Felipe, Labarca, Eduardo, Franco, Daniel Molano, Parra-Tanoux, Daniela, Yepes, David, Hammouda, Ahmed, Elmandouh, Omar, Azzam, Ahmed, Hussein, Aliae Mohamed, Galal, Islam, Awad, Ahmed K., Azab, Mohammed A., Abdalla, Maged, Assal, Hebatallah, Alfishawy, Mostafa, Ghozy, Sherief, Tharwat, Samar, Eldaly, Abdullah, Ellervee, Anneli, Reinhard, Veronika, Chrisment, Anne, Poyat, Chrystelle, Badie, Julio, Berdaguer Ferrari, Fernando, Weiss, Björn, Schellenberg, Clara, Grunow, Julius J, Lorenz, Marco, Schaller, Stefan J, Spieth, Peter, Bota, Marc, Fichtner, Falk, Fuest, Kristina, Lahmer, Tobias, Herrmann, Johannes, Meybohm, Patrick, Markou, Nikolaos, Vasileiadou, Georgia, Chrysanthopoulou, Evangelia, Papamichalis, Panagiotis, Soultati, Ioanna, Jog, Sameer, Kalvit, Kushal, Nainan Myatra, Sheila, Krupa, Ivan, Tharwat, Aisa, Nichol, Alistair, McCarthy, Aine, Mahmoodpoor, Ata, Tonetti, Tommaso, Isoni, Paolo, Spadaro, Savino, Volta, Carlo Alberto, Mirabella, Lucia, Noto, Alberto, Florio, Gaetano, Guzzardella, Amedeo, Paleari, Chiara, Baccanelli, Federica, Savi, Marzia, Antonelli, Massimo, De Pascale, Gennaro, Vaccarini, Barbara, Montrucchio, Giorgia, Sales, Gabriele, Donadello, Katia, Gottin, Leonardo, Nizzero, Marta, Polati, Enrico, De Rosa, Silvia, Sulemanji, Demet, Abusalama, Abdurraouf, Elhadi, Muhammed, Jesus, Montelongo Felipe De, Gonzalez, Daniel Rodriguez, Robles, Victor Hugo Madrigal, Canedo, Nancy, Chavez, Alejandro Esquivel, Dendane, Tarek, Grady, Bart, de Jong, Ben, van der Heiden, Eveline, Thoral, Patrick, van den Bogaard, Bas, Spronk, Peter E., Achterberg, Sefanja, Groeneveld, Melanie, So, Ralph K. L., de Wijs, Calvin, Scholten, Harm, Beishuizen, Albertus, Cornet, Alexander D., Reidinga, Auke C., Kranen, Hetty, Mensink, Roos, den Boer, Sylvia, de Groot, Marcel, Beck, Oliver, Bethlehem, Carina, van Bussel, Bas, Frenzel, Tim, de Jong, Celestine, Wilting, Rob, Mehagnoul-Schipper, Jannet, Alasia, Datonye, Kumar, Ashok, Qayyum, Ahad, Rana, Muhammad, Jayyab, Mustafa Abu, Sierra, Rosario Quispe, Hernandez, Aaron Mark, Taborda, Lúcia, Anselmo, Mónica, Ramires, Tiago, Silva, Catarina, Roriz, Carolina, Morais, Rui, Póvoa, Pedro, Patricio, Patricia, Pinto, André, Santos, Maria Lurdes, Costa, Vasco, Cunha, Pedro, Gonçalves, Celina, Nunes, Sandra, Camões, João, Adrião, Diana, Oliveira, Ana, Omrani, Ali, Maslamani, Muna Al, elbuzidi, Abdurrahmaan Suei, qudah, Bara Mahmoud Al, Akkari, Abdel Rauof, Alkhatteb, Mohamed, Baiou, Anas, Husain, Ahmed, Alwraidat, Mohamed, Saif, Ibrahim Abdulsalam, Bakdach, Dana, Ahmed, Amna, Aleef, Mohamed, Bintaher, Awadh, Petrisor, Cristina, Popov, Evgeniy, Popova, Ksenia, Dementienko, Mariia, Teplykh, Boris, Pyregov, Alexey, Davydova, Liubov, Vladislav, Belskii, Neporada, Elena, Zverev, Ivan, Meshchaninova, Svetlana, Sokolov, Dmitry, Gavrilova, Elena, Shlyk, Irina, Poliakov, Igor, Vlasova, Marina, Aljuhani, Ohoud, Alkhalaf, Amina, Humaid, Felwa Bin, Arabi, Yaseen, Kuhail, Ahmed, Elrabi, Omar, Ghannam, Madihah E., Kansal, Amit, Ho, Vui Kian, Ng, Jensen, García, Raquel Rodrígez, Fraga, Xiana Taboada, del Pilar García-Bonillo, Ma, Padilla-Serrano, Antonio, Cuadrado, Marta Martin, Ferrando, Carlos, Catalan-Monzon, Ignacio, Frutos-Vivar, Fernando, Jimenez, Jorge, Rodríguez-Solis, Carmen, Franquesa-Gonzalez, Enric, Acosta, Guillermo Pérez, Cabrera, Luciano Santana, Parra, Juan Pablo Aviles, Gonzalez, Francisco Muñoyerro, del Carmen Conesa, Maria Lorente, Varela, Ignacio Yago Martinez, Pravia, Orville Victoriano Baez, Delgado, Maria Cruz Martin, de Cabo, Carlos Munoz, Ioan, Ana-Maria, Perez-Calvo, Cesar, Santos, Arnoldo, Abad-Motos, Ane, Ripolles-Melchor, Javier, Martin, Belén Civantos, Teruel, Santiago Yus, Lucas, Juan Higuera, Ortiz, Aaron Blandino, de Pablo Sánchez, Raúl, Barrueco-Francioni, Jesús Emilio, Espina, Lorena Forcelledo, Bonell-Goytisolo, José M., Salaverria, Iñigo, Mir, Antonia Socias, Rodriguez-Ruiz, Emilio, Valverde, Virginia Hidalgo, Cubero, Patricia Jimeno, Linde, Francisca Arbol, Leganes, Nieves Cruza, Romeu, Juan Maria, Concha, Pablo, Berezo-Garcia, José Angel, Fraile, Virginia, Cuenca-Rubio, Cristina, Pérez-Torres, David, Serrano, Ainhoa, Valero, Clara Martínez, Suner, Andrea Ortiz, Larrañaga, Leire, Legaristi, Noemi, Ferrigno, Gerardo, Khlafalla, Safa, Bihariesingh-Sanchit, Rosita, Zoerner, Frank, Grip, Jonathan, Kilsand, Kristina, Mårtensson, Johan, Österlind, Jonas, von Seth, Magnus, Berkius, Johan, Ceruti, Samuele, Glotta, Andrea, Izdes, Seval, Turan, Işıl Özkoçak, Cosar, Ahmet, Halacli, Burcin, Dereli, Necla, Yilmaz, Mehmet, Akbas, Türkay, Elay, Gülseren, Eyüpoğlu, Selin, Bílír, Yelíz, Saraçoğlu, Kemal Tolga, Kaya, Ebru, Sahin, Ayca Sultan, Ekren, Pervin Korkmaz, Mengi, Tuğçe, Suner, Kezban Ozmen, Tomak, Yakup, Eroglu, Ahmet, Alsabbah, Asad, Hanlon, Katie, Gervin, Kevin, McMahon, Sean, Hagan, Samantha, Higenbottam, Caroline V, Mullhi, Randeep, Poulton, Lottie, Torlinski, Tomasz, Gareth, Allen, Truman, Nick, Vijayakumar, Gopal, Hall, Chris, Jubb, Alasdair, Cagova, Lenka, Jones, Nicola, Graham, Sam, Robin, Nicole, Cowton, Amanda, Donnelly, Adrian, Singatullina, Natalia, Kent, Melanie, Boulanger, Carole, Campbell, Zoë, Potter, Elizabeth, Duric, Natalie, Szakmany, Tamas, Kviatkovske, Orinta, Marczin, Nandor, Ellis, Caroline, Saha, Rajnish, Sri-Chandana, Chunda, Allan, John, Mumelj, Lana, Venkatesh, Harish, Gotz, Vera Nina, Cochrane, Anthony, Ficial, Barbara, Kamble, Shruthi, Lumlertgul, Nuttha, Oddy, Christopher, Jain, Susan, Crapelli, Giulia Beatrice, Vlachou, Aikaterini, Golden, David, Garrioch, Sweyn, Henning, Jeremy, Loveleena, Gupta, Davey, Miriam, Grauslyte, Lina, Salciute-Simene, Erika, Cook, Martin, Barling, Danny, Broadhurst, Phil, Purvis, Sarah, Spivey, Michael, Shuker, Benjamin, Grecu, Irina, Harding, Daniel, Dean, James T., Nielsen, Nathan D., Al-Bayati, Sama, Al-Sadawi, Mohammed, Charron, Mariane, Stubenrauch, Peter, Santanilla, Jairo, Wentowski, Catherine, Rosenberger, Dorothea, Eksarko, Polikseni, and Jawa, Randeep

Abstract

Background: Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave. Methods: This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs. Results: Mobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p = 0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p ≤ 0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p = 0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p = 0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p = 0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI − 0.47, 1.37, p = 0.34) and hospital (adj. difference 1.4 days; 95% CI − 0.62, 2.35, p = 0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p = 0.24) when adjusted for covariates. Conclusions: Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility. Trial registration ClinicalTrials.gov: NCT04

Published
2023

7. Understanding the Symbolic Effects of Gender Representation: A Multi-Source Study in Education.

Author

Doornkamp, L., Groeneveld, S., Groeneveld, M. G., Van der Pol, L. D., and Mesman, J.

Subjects
BUREAUCRACY, HIGH school girls, DUTCH language
Abstract

Symbolic effects of bureaucratic representation assume that outcomes for citizen-clients change in response to the mere presence of bureaucrats with similar backgrounds. The social-psychological mechanisms in clients that may explain these changes are barely examined, though. Based on multi-source data on male and female high school students in the Netherlands, this study empirically tests a theoretical model that links student-teacher gender congruence to students' performance in math and Dutch language through the mediating role of students' gender-stereotypical beliefs and self-perceived abilities. The empirical analyses do not support the hypotheses. For student performance in math, no effects were found, while for Dutch language, a negative gender-representation effect was found for male students. In all, the results point at divergent relations between gender congruence, self-perceived abilities and performance for male and female students across subjects. The null results in this study suggest that symbolic effects of gender representation may be affected by national context and socio-economic status which should be considered as new frontiers for future research on representative bureaucracy. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Understanding gender bias in teachers’ grading: The role of gender stereotypical beliefs

Author

Doornkamp, L., Van der Pol, L. D., Groeneveld, S., Mesman, J., Endendijk, J. J., Groeneveld, M. G., Leerstoel Baar, Development and Treatment of Psychosocial Problems, Leerstoel Baar, and Development and Treatment of Psychosocial Problems

Subjects
Gender grading bias, Implicit gender-typed expectations, Implicit gender-typed associations, Implicit gender stereotypes, Education
Abstract

This study experimentally tested the influence of secondary school students' gender on Dutch language and math teachers' grading (n = 358) and examined the role of teachers' gender and gender stereotypes in gender grading bias. Results showed that grading, on average, was not gender biased. However, differences between teachers' gender grading bias were related to their gender stereotypes. Although we found no direct effect of teachers' gender on grading bias, for math we found an indirect effect through their gender stereotypes. This study provides evidence for the role of teachers’ gender stereotypes in gender grading bias that thus far had only been assumed.

Published
2022

9. Ambulante Ernährungsberatung ist für die Prävention und Therapie chronischer Erkrankungen medizinisch notwendig: Ein Positionspapier von DGEM, DAG, DDG, DGVS, DGK, DAEM, BDEM, Deutscher Allianz fürnichtübertragbare Krankheiten und VDOE anlässlich des Beschlusses des Gemeinsamen Bundesausschusses vom 9. Februar 2015

Author

Bosy-Westphal, A., Adam, O., Bischoff, S., Gerlach, S., Gohlke, H., Groeneveld, M., Hauner, H., Krebs, E., Lamprecht, G., Müller, M. J., Norman, K., Plauth, M., Pfeiffer, A., Rittler, P., Wabitsch, M., and Wechsler, J. G.

Published
2016
Full Text
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10. Understanding gender bias in teachers’ grading: The role of gender stereotypical beliefs

Author

Leerstoel Baar, Development and Treatment of Psychosocial Problems, Doornkamp, L., Van der Pol, L. D., Groeneveld, S., Mesman, J., Endendijk, J. J., Groeneveld, M. G., Leerstoel Baar, Development and Treatment of Psychosocial Problems, Doornkamp, L., Van der Pol, L. D., Groeneveld, S., Mesman, J., Endendijk, J. J., and Groeneveld, M. G.

Published
2022

11. The influence of pH on dissolved organic matter fluorescence in inland waters

Author

Swedish National Science Foundation, Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, European Commission, Knut and Alice Wallenberg Foundation, Agencia Estatal de Investigación (España), Groeneveld, M., Catalán, Núria, Einarsdottir, K., Bravo, Andrea G., Kothawala, Dolly N., Swedish National Science Foundation, Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, European Commission, Knut and Alice Wallenberg Foundation, Agencia Estatal de Investigación (España), Groeneveld, M., Catalán, Núria, Einarsdottir, K., Bravo, Andrea G., and Kothawala, Dolly N.

Abstract

Fluorescence is an easily available analytical technique used to assess the optical characteristics of dissolved organic matter (DOM). Despite widespread use, there has been some confusion about how robust fluorescence spectroscopy is to differences in solution pH. Here we assess fluorescence characteristics of three natural water samples and one commercially available standard (Nordic Reservoir) by modifying the pH across a range from 3.5 to 9.0 at 0.5 pH increments. We used two statistical approaches to assess if fluorescence intensity shifted significantly across this pH range. We identified that humic-like and protein-like fluorescence was largely stable within the pH range of 5.5 to 7.5, which represents 80% of Swedish lakes and streams. Likewise, we found that the three commonly used fluorescence indices were robust across the full pH range tested with the exception of the humification index, which had a narrower range of stability. The commerical humic substance sample was highly unstable with changes to pH in the regions of protein-like fluorescence being particularly sensitive. One of our conclusions is that differences in fluorescence intensity in the pH range of 5.5 to 7.5, typical for most inland waters, are generally minor. We recommend adjusting the pH when samples fall outside this region and to be especially careful in interpreting results from commercial humic substances

Published
2022

14. Automated Assessment of COVID-19 Reporting and Data System and Chest CT Severity Scores in Patients Suspected of Having COVID-19 Using Artificial Intelligence

Author

Lessmann, N., Sanchez, C.I., Beenen, Ludo, Boulogne, L.H., Brink, M., Calli, E., Dofferhoff, A.S.M., Everdingen, W.M. van, Gerke, P.K., Groeneveld, M., Harten, L. van, Hendrix, W.J.M., Huisman, H.J., Jacobs, C., Kok, Michel, Krdzalic, J., Leeuwen, K.G. van, Meakin, J.A., Overkamp, M., Rikxoort, E.M. van, Samperna, R., Schaefer-Prokop, C.M., Schalekamp, S., Scholten, E.T., Sital, C.K., Teuwen, J.J.B., Vente, C.W. de, Xie, W., Wilde, B. de, Prokop, M., Ginneken, B. van, Lessmann, N., Sanchez, C.I., Beenen, Ludo, Boulogne, L.H., Brink, M., Calli, E., Dofferhoff, A.S.M., Everdingen, W.M. van, Gerke, P.K., Groeneveld, M., Harten, L. van, Hendrix, W.J.M., Huisman, H.J., Jacobs, C., Kok, Michel, Krdzalic, J., Leeuwen, K.G. van, Meakin, J.A., Overkamp, M., Rikxoort, E.M. van, Samperna, R., Schaefer-Prokop, C.M., Schalekamp, S., Scholten, E.T., Sital, C.K., Teuwen, J.J.B., Vente, C.W. de, Xie, W., Wilde, B. de, Prokop, M., and Ginneken, B. van

Abstract

Contains fulltext : 228667.pdf (Publisher’s version ) (Open Access)

Published
2021

19. De ladder voor duurzame verstedelijking. Houdbaarheidsdatum in zicht?

Author

Swart-Groeneveld, M.

Abstract

De ladder voor duurzame verstedelijking (ladder) is bedoeld om een zorgvuldige afweging te maken ten aanzien van het gebruik van de ruimte in Nederland. Onnodige uitbreidingen van het stedelijke gebied en leegstand dienen hiermee te worden voorkomen. Overheden zijn, door de opname van de ladder in artikel 3.1.6 lid 2 Besluit ruimtelijke ordening (Bro), verplicht om in de toelichting van bestemmingsplannen en in de onderbouwing van ruimtelijke plannen de toepassing van de ladder inzichtelijk te maken en te verantwoorden. De ‘laddertoets’ bestaat uit drie stappen (treden). Allereerst moet worden vastgesteld of er sprake is van een nieuwe stedelijke ontwikkeling. De definitie van ‘stedelijke ontwikkeling’ luidt: ‘Een ruimtelijke ontwikkeling van een bedrijventerrein of zeehaventerrein, of van kantoren, detailhandel, woningbouwlocaties of andere stedelijke voorzieningen’. Valt een ontwikkeling niet onder het begrip ‘stedelijke ontwikkeling’, dan is de ladder niet van toepassing. Is er wel sprake van een nieuwe stedelijke ontwikkeling, dan moeten de ‘treden’ van de ladder te worden doorlopen zoals opgenomen in artikel 3.1.6 lid 2 Bro.

Published
2016

22. Abstracts of papers medicinal chemical meeting

Author

Damsma, G., Westerink, B. H. C., de Vries, J. B., Horn, A. S., Rettenmayr, N., de Miranda, J. F. Rodrigues, Lambrecht, G., Mutschler, E., Russel, F. G. M., van Galen, P. J. M., van Viijmen, H. W. Th., Ijzerman, A. P., Soudijn, W., Vromans, R. M., van de Straat, R., Groeneveld, M., Vermeiden, N. P. E., Siero, H. L. M., van Zwam, A. J. G., de Miranda, J. F. Rodriques, van Ginneken, C. A. M., Willems, P. H. G. M., de Pont, J. J. H. H. M., van Gelderen, J. G., Pruijn, F. B., Bast, A., de Zwart, M. A. H., van der Goot, H., Timmerman, H., Kramer, K., Voss, H. P., Grimbergen, J. A., Goeptar, A. R., Haenen, G. R. M. M., Veerman, M., Vermeulen, N. P. E., Boom, S. P. A., Koper, J. G., Leurs, J. N. L. Go. R., Rekka, E., Sterk, G. J., van der Weide, Jan, Tendijck, H., Tepper, P. G., Horn, A. B., Bosker, F. J., van Bussel, F. J., Plug, M. J., Dijk, J., Tepper, P., Möller, W., Leusen, F. J. J., van Vlijmen, H. W. Th., de Kaste, D., van Amsterdam, J. G. C., Llorens-Cortes, C., Vleeming, W., v. d. Wouw, P. A., v. Rooij, H. H., Wemer, J., Porsius, A. J., Lusthof, K. J., de Mol, N. J., Janssen, L. H. M., Bakri, Aziz, Janssen, Lambert H. M., Wilting, Jaap, Kelder, P. P., Kuit, M. C. A. W., van Sterkenburg, E. L. M., Wilting, J., Bos, O. J. M., and Fischer, M. J. E.

Published
1987
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25. Identification and functional characterization of the Lactococcus lactis CodY-regulated branched-chain amino acid permease BcaP (CtrA)

Author

den Hengst, CD, Groeneveld, M, Kuipers, OP, Kok, J, Hengst, Chris D. den, Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology, Enzymology, Biotechnology, and Faculty of Science and Engineering

Subjects
GRAM-POSITIVE BACTERIA, Amino Acid Transport Systems, Nitrogen, Physiology and Metabolism, Branched-chain amino acid, Molecular Sequence Data, GLOBAL REGULATOR, Microbiology, BACILLUS-SUBTILIS, chemistry.chemical_compound, Bacterial Proteins, Valine, COMPLETE GENOME SEQUENCE, Amino acid transporter, TRANSPORT-SYSTEM, Molecular Biology, chemistry.chemical_classification, biology, STATIONARY-PHASE, Permease, Lactococcus lactis, SALMONELLA-TYPHIMURIUM, Gene Expression Regulation, Bacterial, biology.organism_classification, CONTROLLED GENE-EXPRESSION, STREPTOCOCCUS-CREMORIS, Amino acid, Amino acid permease, DNA-Binding Proteins, Repressor Proteins, Amino Acids, Sulfur, Biochemistry, chemistry, Genes, Bacterial, Leucine, Amino Acids, Branched-Chain, MEMBRANE-VESICLES, Transcription Factors
Abstract

Transcriptome analyses have previously revealed that a gene encoding the putative amino acid transporter CtrA (YhdG) is one of the major targets of the pleiotropic regulator CodY inLactococcus lactisandBacillus subtilis. The role ofctrAinL. lactiswas further investigated with respect to both transport activity as well as CodY-mediated regulation. CtrA is required for optimal growth in media containing free amino acids as the only amino acid source. Amino acid transport studies showed thatctrAencodes a secondary amino acid transport system that is specific for branched-chain amino acids (BCAAs) (isoleucine, leucine, and valine) and methionine, which is in disagreement with its previously proposed function (a cationic amino acid transporter), which was assigned based on homology. We propose to rename CtrA BcaP, for branched-chain amino acid permease. BcaP is a member of a group of conserved transport systems, as homologs are widely distributed among gram-positive bacteria. Deletion ofbcaPresulted in the loss of most of the BCAA uptake activity ofL. lactis, indicating that BcaP is the major BCAA carrier of this organism. Deletion ofbcaPtogether with a second (putative) BCAA permease, encoded bybrnQ, further reduced the viability of the strain. DNA microarray analysis showed that deletion ofbcaPpredominantly affects genes belonging to the regulons of the transcriptional regulator CodY, which is involved in global nitrogen metabolism and needs BCAAs for its activation, and of CmbR, which is involved in sulfur amino acid metabolism.

Published
2006

26. No effects of dominance rank or sex on spatial behaviour of rabbits

Author

Dekker, J.J.A., Groeneveld, M., and van Wieren, S.E.

Subjects
rabbits, dominantie, konijnen, social dominance, animal behaviour, PE&RC, dominance, operating range, oryctolagus cuniculus, actieradius, ranking, rangordening, sociale dominantie, Wildlife Ecology and Conservation, habitats, diergedrag, sex, geslacht (sex)
Abstract

The home range is an important measure of the spatial behaviour of animals. In rabbits Oryctolagus cuniculus), spatial behaviour may be affected by social rank and sex. Subdominant animals are expected to have a larger home range and to forage farther from the burrow than dominant animals. Females are expected to have a smaller home range than males. To test these hypotheses, we determined home range size and distance to the burrow during foraging within a low density, semi-natural rabbit population in the Netherlands, using daytime observations of marked individuals. Individual median distance to the nearest burrow during foraging ranged from 3 to 16 m. Home range varied between 0.01 and 0.43 ha, which is the smallest home range area reported for rabbits in Europe. We found no difference in home range or foraging distance between males or females, or between dominant and subdominant animals. We postulate that this is caused by an interaction of two factors: low animal density and high availability of high quality food. This meant that there was no need to compete for best or safest foraging locations, and males did not need to protect females in their group against other males. This is also our explanation as to why the home ranges in our study are the smallest recorded. De home range (activiteitsgebied) is een belangrijke maat van het ruimtegebruik van een dier. Bij konijnen (Oryctolagus cuniculus) hebben geslacht en sociale rang van het dier mogelijk invloed op de omvang van de home range. Van dominante dieren is te verwachten dat ze kleinere home ranges hebben dan subdominante dieren, en vrouwelijke dieren kleinere home ranges dan mannelijke. Daarnaast zouden subdominante dieren op grotere afstand van de boucht moeten foerageren dan dominante. Deze hypotheses zijn getest door de home range grootte en afstanden tot de dichtstbijzijnde burcht van konijnen te bepalen in een halfnatuurlijke populatie konijnen met een dichtheid van 5 konijnen per ha

Published
2006

27. Applying the business excellence model to a research organization

Author

Weggeman, M.C.D.P., Groeneveld, M., and Innovation Technology Entrepr. & Marketing

Abstract

A research-specific application of the well-known EFQM Business Excellence model has been experimented with at Philips Research Labs and Shell Exploratory Research. The research-specific application of the model is predominantly based on two choices: taking a research perspective rather than an R&D or development perspective, and considering a research organization as a culture instead of, for instance, a machine or an organism. the model was operationalized into a set of tangible recommendations that proved to be relevant to research management, specifically to first-line supervisors of research groups. This article presents recommendations that will assist industrial labs struggling with that stubborn question: what exactly does quality management in research mean?

Published
2005

28. Stelt zich voor

Author

Groeneveld, M.

Abstract

De Bestuurskundige Evaluatiecommissie Leiden, beter bekend onder de naam 'B.E.L.' is één van de commissies die de B.I.L. rijk is. Voor vele actieve B.I.L.'ers kan de B.E.L. een relatief onzichtbare commissie lijken. Toch doet deze commissie heel erg belangrijk werk.

Published
2005

30. Taakbesteding en taakbelasting op brede scholen

Author

Groeneveld, M., Frielink, S., Rooijen, E. van, and TNO Arbeid

Subjects
Enquetes, Onderwijzend personeel, Docenten, Lager onderwijs, Nederland, Basisonderwijs, Workplace, Werkdruk, Onderwijs, Speciaal onderwijs
Abstract

Brede scholen zijn netwerken van onderwijs- en andere (welzijns)instellingen, die onder andere tot doel hebben de ontwikkelingskansen van alle kinderen te vergroten en de wijk bij de school te betrekken. Om te inventariseren of deze verbreding tot taakvergroting of zwaardere taakbelasting bij schoolleiders en leraren heeft geleid zijn vragenlijsten naar 252 scholen gestuurd. Een van de uitkomsten van het onderzoek is dat een brede school een achterstandsschool is. De taakomvang van de leraren komt overeen met die op niet-brede scholen. Directeuren geven op dat zij meer tijd aan verschillende taken moeten besteden dan voor de verbreding. De taakbelasting van leraren op brede scholen verschilt niet van die op niet-brede; in het algemeen is de taakbelasting van leraren wel hoger dan gemiddeld. Van de leidinggevenden die vonden dat hun taakbelasting zwaarder was geworden kon ook worden geconstateerd dat zij hun werk juist minder emotioneel uitputtend waren gaan vinden na de verbreding. B&A-groep een TNO voerde dit onderzoek uit in opdracht van het ministerie van OCW.

Published
2002

31. In-process measurements of material removal in fluid jet polishing

Author

Brug, H. van, Groeneveld, M., Booij, S.M., Braat, J.J.M., and Technisch Physische Dienst TNO - TH

Subjects
Fluid jet polishing (FJP), Mathematical models, Interferometry, Surface roughness, Polishing, In-process, Optical fabrication, Temporal phase unwrapping, FJP
Abstract

A prototype of a system for in-process monitoring of material removal in fluid jet polishing (FJP) is presented. The measurements make use of temporal phase unwrapping (TPU) allowing for a large working range. The measurement system will be discussed, with all problems that had to be overcome like water on the surface and vibrations, as well as the FJP system. The basics behind TPU will be presented and the first results will be shown. Finally, the capabilities of the system will be discussed. The presented system enables the in-process monitoring of the footprint as obtained by the FJP technique and measurement of the material removal rate.

Published
2002

32. Taakbesteding en taakbelasting van leraren in het Voortgezet Onderwijs : kalenderjaar 2000

Author

Backbier, E., Frielink, S.J., Groeneveld, M., and Simons, J.

Subjects
Functieopbouw, Onderwijzend personeel, Docenten, Voortgezet onderwijs, Nederland, Workplace, Werkdruk, Onderwijs, Werkverdeling, Taakverdeling, Middelbaar onderwijs
Abstract

In dit rapport wordt verslag gedaan van onderzoek, uitgevoerd door TNO Arbeid en de B&A Groep in opdracht van het Ministerie van Onderwijs, Cultuur en Wetenschappen, naar taakbesteding en taakbelasting van docenten in het voortgezet onderwijs (VO en VSO). De verzameling van de gegevens heeft plaatsgevonden gedurende het jaar 2000. De resultaten en conclusies in deze rapportage hebben betrekking op de 'gemiddelde docent' in het voortgezet onderwijs.

Published
2001

33. Taakbesteding en taakbelasting van docenten in de BVE-sector : kalenderjaar 2000

Author

Backbier, E., Franck, E., Groeneveld, M., and Simons, J.

Subjects
Functieopbouw, Onderwijzend personeel, Docenten, Beroepsonderwijs, Volwasseneneducatie, Vormingswerk volwassenen, Vakonderwijs, Nederland, Workplace, Werkdruk, Onderwijs, Werkverdeling, Taakverdeling
Abstract

In dit rapport wordt verslag gedaan van onderzoek, uitgevoerd door TNO Arbeid en de B&A Groep in opdracht van het Ministerie van Onderwijs, Cultuur en Wetenschappen, naar taakbesteding en taakbelasting van docenten in de sector beroepsonderwijs en volwasseneneducatie (BVE). De verzameling van de gegevens heeft plaatsgevonden gedurende het jaar 2000. De resultaten en conclusies in deze rapportage hebben betrekking op de 'gemiddelde docent' in de BVE.

Published
2001

34. Taakbesteding en taakbelasting van leraren in het Primair Onderwijs : kalenderjaar 2000

Author

Backbier, E., Frielink, S.J., and Groeneveld, M.

Subjects
Functieopbouw, Onderwijzend personeel, Docenten, Buitengewoon onderwijs, Lager onderwijs, Nederland, Basisonderwijs, Workplace, Werkdruk, Speciaal onderwijs, Onderwijs, Werkverdeling, Taakverdeling
Abstract

In dit rapport wordt verslag gedaan van onderzoek, uitgevoerd door TNO Arbeid en de B&A Groep in opdracht van het Ministerie van Onderwijs, Cultuur en Wetenschappen, naar taakbesteding en taakbelasting van docenten in het primair onderwijs (basisonderwijs en speciaal onderwijs). De verzameling van de gegevens heeft plaatsgevonden gedurende het jaar 2000. De resultaten en conclusies in deze rapportage hebben betrekking op de 'gemiddelde docent' in het primair onderwijs.

Published
2001

39. Photochemical mineralisation in a humic boreal lake: temporal variability and contribution to carbon dioxide production.

Author

Groeneveld, M. M., Tranvik, L. J., and Koehler, B.

Subjects
PHOTOCHEMISTRY, CARBON dioxide, CHROMOPHORES, ATMOSPHERIC carbon dioxide, EMISSIONS (Air pollution)
Abstract

Sunlight induces photochemical mineralisation of chromophoric dissolved organic matter (CDOM) to dissolved inorganic carbon (DIC) in inland waters, resulting in carbon dioxide (CO2) emissions to the atmosphere. Photochemical rate modelling is used to determine sunlight-induced CO2 emissions on large spatial and temporal scales. A sensitive model parameter is the wavelength-specific photochemical CDOM reactivity, the apparent quantum yield (AQY). The modelling studies so far assume that AQY spectra determined for single lakes and on single occasions represent larger spatial and temporal scales. Here, we studied a humic boreal lake in Sweden. We measured AQY spectra for photochemical DIC production monthly between June and November 2014 and parameterised a photochemical rate model. Photochemical reactivity increased slightly during the open water period, likely due to a high rainfall event with consecutive mixing in autumn that increased availability of highly photoreactive CDOM. However, the variability in AQY spectra over time was much smaller than previously reported variability in AQY spectra across lakes. Yet, using either the AQY spectrum from the least or from the most photoreactive water sample resulted in a 5-fold difference in simulated annual DIC photoproduction (2.0 ± 0.1 and 10.3 ± 0.7 g C m-2 yr-1, respectively). Using the monthly measured AQY spectrum to simulate DIC photoproduction for month-long time periods resulted in an apparent time lag between irradiance and DIC photoproduction. This suggested that temporal variability in AQY spectra occurs on shorter time scales. Therefore, we parameterised the model with the pooled AQY spectrum of six monthly measurements. Simulated DIC photoproduction for three years (2012-2014) averaged 4.5 ± 0.2 g C m-2 yr-1, which represented 3% of the mean CO2 emissions from this lake. We conclude that (1) it may be recommendable to conduct repeated AQY measurements across the season for more accurate simulation of annual photochemical DIC production in lakes and (2), in agreement with previous studies, direct CDOM photomineralisation makes only a minor contribution to mean CO2 emissions from Swedish humic lakes. [ABSTRACT FROM AUTHOR]

Published
2015
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44. Alkaline Phosphatase Activity in the Periodontal Ligament and Gingiva of the Rat Molar: Its Relation to Cementum Formation.

Author

Groeneveld, M. C., Everts, V., and Beertsen, W.

Subjects
ALKALINE phosphatase, GLYCOPROTEINS, PERIODONTAL ligament, GINGIVA, CEMENTUM, MOLARS, RAT physiology
Abstract

Alkaline phosphatase (ALP) is a glycoprotein thought to be involved in processes leading to mineral formation in tissues like bone and cementum. In the rat molar periodontium, several regions are associated with the formation of cementum (periodontal ligament, inner part of the gingiva), whereas other areas are not (e.g., the outer part of the gingiva just beneath the outer oral epithelium). In an attempt to establish how the spatial distribution of ALP activity relates to cementum formation, we assessed the activity of the enzyme quantitatively in the periodontium of the rat maxillary molars, by using the indoxyl-tetrazolium salt method. It appeared that the distribution of enzyme activity in the ligament was heterogeneous, indicating local variations in the phosphate household. Highest activity was found in areas related to mineralization, adjacent to the alveolar bone and cementum. Enzyme activity was higher adjacent to cellular cementum than to acellular cementum. With respect to acellular cementum, a highly significant positive correlation was found between ALP activity and cementum thickness, which indicates a close relationship between local phosphate production and cementum formation rate. An interesting observation in the connective tissue of the gingiva mesial to the first molar was a sharp demarcation between an ALP-positive inner part, adjacent to the tooth, and an ALP-negative outer part, underneath the outer oral epithelium. In the interdental gingiva, the entire connective tissue proved positive for the enzyme, suggesting that this region consists of the combined inner gingival parts of two adjacent teeth. [ABSTRACT FROM AUTHOR]

Published
1995
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45. Formation of Afibrillar Acellular Cementum-like Layers Induced by Alkaline Phosphatase Activity from Periodontal Ligament Explants Maintained in vitro.

Author

Groeneveld, M. C., Everts, V., and Beertsen, W.

Subjects
PERIODONTAL ligament, ALKALINE phosphatase, FIBROBLASTS, CEMENTUM, CALCIFICATION, LABORATORY rats
Abstract

Fibroblasts of the periodontal ligament, by their alkaline phosphatase (ALP) activity, are considered to play a role in the formation of acellular cementum. As a means of exploring this hypothesis, periodontal ligament explants from rat incisors were cultured in direct contact with bovine dentin slices in the presence of 10 mmol/L β-glycerophosphate. Periosteal and pericardial tissue explants were maintained under similar conditions. After two weeks, the slices were harvested and processed for electron microscopic examination. Controls included periodontal ligament explants to which the ALP-inhibitor levamisole was added. The results suggest that only ALP-positive cultures from periodontal ligament and periosteum form mineralized layers along the dentin. After demineralization, layers consisted of fine filamentous or granular material of moderate electron-density and resembled afibrillar acellular cementum. Our findings support the hypothesis that periodontal ligament fibroblasts, by means of their ALP activity, play a pivotal role in the formation of acellular cementum. [ABSTRACT FROM AUTHOR]

Published
1994
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46. A Quantitative Enzyme Histochemical Analysis of the Distribution of Alkaline Phosphatase Activity in the Periodontal Ligament of the Rat Incisor.

Author

GROENEVELD, M. C., EVERTS, V., and BEERTSEN, W.

Subjects
ALKALINE phosphatase, PERIODONTAL ligament, INCISORS, LABORATORY rats, CEMENTUM, GINGIVA
Abstract

The spatial distribution of alkaline phosphatase (ALP) activity was examined in the periodontal ligament of the continuously growing rat incisor. With the indoxyl-tetrazolium salt method, enzyme activity was demonstrated in undecalcified cryosections, and the amount of reaction product was quantified. ALP activity appeared to be distributed heterogeneously. Its highest activity was found in the bone-related compartment of the ligament. In the tooth-related compartment and the supracrestal extension of the ligament, enzyme activity was significantly lower, but still higher than in the lamina propria of the gingiva. In the part of the ligament bordering the cementum, highest activity was found in the apical region just occlusal to Hertwigs epithelial root sheath, where formation of a cellular cementum begins. From there toward the incisal edge, the activity of the enzyme gradually decreased. It is suggested that differences among the various parts of the periodontal ligament are related to local variations in phosphate metabolism and cementum deposition. [ABSTRACT FROM AUTHOR]

Published
1993
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48. The influence of pH on dissolved organic matter fluorescence in inland waters

Author

Groeneveld, M., Catalán, Núria, Einarsdottir, K., Bravo, Andrea G., Kothawala, Dolly N., Uppsala University, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre d'Investigació i Desenvolupament [Barcelona] (CID-CSIC), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), European Project: 839709,CHROME - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions, Swedish National Science Foundation, Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning, European Commission, Knut and Alice Wallenberg Foundation, and Agencia Estatal de Investigación (España)

Subjects
[SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Miljövetenskap, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, Environmental Sciences
Abstract

10 pages, 4 figures, 1 table, supplementary information https://doi.org/10.1039/D1AY01702K, Fluorescence is an easily available analytical technique used to assess the optical characteristics of dissolved organic matter (DOM). Despite widespread use, there has been some confusion about how robust fluorescence spectroscopy is to differences in solution pH. Here we assess fluorescence characteristics of three natural water samples and one commercially available standard (Nordic Reservoir) by modifying the pH across a range from 3.5 to 9.0 at 0.5 pH increments. We used two statistical approaches to assess if fluorescence intensity shifted significantly across this pH range. We identified that humic-like and protein-like fluorescence was largely stable within the pH range of 5.5 to 7.5, which represents 80% of Swedish lakes and streams. Likewise, we found that the three commonly used fluorescence indices were robust across the full pH range tested with the exception of the humification index, which had a narrower range of stability. The commerical humic substance sample was highly unstable with changes to pH in the regions of protein-like fluorescence being particularly sensitive. One of our conclusions is that differences in fluorescence intensity in the pH range of 5.5 to 7.5, typical for most inland waters, are generally minor. We recommend adjusting the pH when samples fall outside this region and to be especially careful in interpreting results from commercial humic substances, This work was supported by funding from the Swedish National Science Foundation (D. N. K.) Vetenskapsrådet starting grant (VR 2016-04108), open call (VR 2020-03249), the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS 201800778), an early career research award from King Carl XVI Gustaf of Sweden, a Marie Sklodowska Curie Action of the European Commission to N. C. (CHROME - 839709) and the Knut and Alice Wallenberg Foundation (Wallenberg Scholar KAW 2018-0191), With the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)

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