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824 results on '"Grosu, A. L."'

4. Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities

Author

Gkika, E., Kostyszyn, D., Fechter, T., Moustakis, C., Ernst, F., Boda-Heggemann, J., Sarria, G., Dieckmann, K., Dobiasch, S., Duma, M. N., Eberle, F., Kroeger, K., Häussler, B., Izaguirre, V., Jazmati, D., Lautenschläger, S., Lohaus, F., Mantel, F., Menzel, J., Pachmann, S., Pavic, M., Radlanski, K., Riesterer, O., Gerum, S., Röder, F., Willner, J., Barczyk, S., Imhoff, D., Blanck, O., Wittig, A., Guckenberger, M., Grosu, Anca-L., and Brunner, T. B.

Published
2023
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6. TRIB1 confers therapeutic resistance in GBM cells by activating the ERK and Akt pathways

Author

Singh, Karnika, Han, Chunhua, Fleming, Jessica L., Becker, Aline P., McElroy, Joseph, Cui, Tiantian, Johnson, Benjamin, Kumar, Ashok, Sebastian, Ebin, Showalter, Christian A., Schrock, Morgan S., Summers, Matthew K., Becker, Valesio, Tong, Zhen-yue, Meng, Xiaomei, Manring, Heather R., Venere, Monica, Bell, Erica H., Robe, Pierre A., Grosu, A. L., Haque, S. Jaharul, and Chakravarti, Arnab

Published
2023
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9. Development of PSMA-PET-guided CT-based radiomic signature to predict biochemical recurrence after salvage radiotherapy

Author

Spohn, Simon K. B., Schmidt-Hegemann, Nina-Sophie, Ruf, Juri, Mix, Michael, Benndorf, Matthias, Bamberg, Fabian, Makowski, Marcus R., Kirste, Simon, Rühle, Alexander, Nouvel, Jerome, Sprave, Tanja, Vogel, Marco M. E., Galitsnaya, Polina, Gschwend, Jürgen E., Gratzke, Christian, Stief, Christian, Löck, Steffen, Zwanenburg, Alex, Trapp, Christian, Bernhardt, Denise, Nekolla, Stephan G., Li, Minglun, Belka, Claus, Combs, Stephanie E., Eiber, Matthias, Unterrainer, Lena, Unterrainer, Marcus, Bartenstein, Peter, Grosu, Anca-L., Zamboglou, Constantinos, and Peeken, Jan C.

Published
2023
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10. Convolutional neural network based deep-learning architecture for intraprostatic tumour contouring on PSMA PET images in patients with primary prostate cancer

Author

Kostyszyn, Dejan, Fechter, Tobias, Bartl, Nico, Grosu, Anca L., Gratzke, Christian, Sigle, August, Mix, Michael, Ruf, Juri, Fassbender, Thomas F., Kiefer, Selina, Bettermann, Alisa S., Nicolay, Nils H., Spohn, Simon, Kramer, Maria U., Bronsert, Peter, Guo, Hongqian, Qiu, Xuefeng, Wang, Feng, Henkenberens, Christoph, Werner, Rudolf A., Baltas, Dimos, Meyer, Philipp T., Derlin, Thorsten, Chen, Mengxia, and Zamboglou, Constantinos

Subjects
Computer Science - Computer Vision and Pattern Recognition, Electrical Engineering and Systems Science - Image and Video Processing, Physics - Medical Physics
Abstract

Accurate delineation of the intraprostatic gross tumour volume (GTV) is a prerequisite for treatment approaches in patients with primary prostate cancer (PCa). Prostate-specific membrane antigen positron emission tomography (PSMA-PET) may outperform MRI in GTV detection. However, visual GTV delineation underlies interobserver heterogeneity and is time consuming. The aim of this study was to develop a convolutional neural network (CNN) for automated segmentation of intraprostatic tumour (GTV-CNN) in PSMA-PET. Methods: The CNN (3D U-Net) was trained on [68Ga]PSMA-PET images of 152 patients from two different institutions and the training labels were generated manually using a validated technique. The CNN was tested on two independent internal (cohort 1: [68Ga]PSMA-PET, n=18 and cohort 2: [18F]PSMA-PET, n=19) and one external (cohort 3: [68Ga]PSMA-PET, n=20) test-datasets. Accordance between manual contours and GTV-CNN was assessed with Dice-S{\o}rensen coefficient (DSC). Sensitivity and specificity were calculated for the two internal test-datasets by using whole-mount histology. Results: Median DSCs for cohorts 1-3 were 0.84 (range: 0.32-0.95), 0.81 (range: 0.28-0.93) and 0.83 (range: 0.32-0.93), respectively. Sensitivities and specificities for GTV-CNN were comparable with manual expert contours: 0.98 and 0.76 (cohort 1) and 1 and 0.57 (cohort 2), respectively. Computation time was around 6 seconds for a standard dataset. Conclusion: The application of a CNN for automated contouring of intraprostatic GTV in [68Ga]PSMA- and [18F]PSMA-PET images resulted in a high concordance with expert contours and in high sensitivities and specificities in comparison with histology reference. This robust, accurate and fast technique may be implemented for treatment concepts in primary PCa. The trained model and the study's source code are available in an open source repository.

Published
2020

11. Identifying core MRI sequences for reliable automatic brain metastasis segmentation

Author

Buchner, Josef A, Peeken, Jan C, Etzel, Lucas, Ezhov, Ivan, Mayinger, Michael, Christ, Sebastian M, Brunner, Thomas B, Wittig, Andrea, Menze, Bjoern H, Zimmer, Claus, Meyer, Bernhard, Guckenberger, Matthias, Andratschke, Nicolaus, El Shafie, Rami A, Debus, Jürgen, Rogers, Susanne, Riesterer, Oliver, Schulze, Katrin, Feldmann, Horst J, Blanck, Oliver, Zamboglou, Constantinos, Ferentinos, Konstantinos, Bilger, Angelika, Grosu, Anca L, Wolff, Robert, Kirschke, Jan S, Eitz, Kerstin A, Combs, Stephanie E, Bernhardt, Denise, Rueckert, Daniel, Piraud, Marie, Wiestler, Benedikt, and Kofler, Florian

Published
2023
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13. The maximum standardized uptake value in patients with recurrent or persistent prostate cancer after radical prostatectomy and PSMA-PET-guided salvage radiotherapy—a multicenter retrospective analysis

Author

Spohn, Simon K. B., Farolfi, Andrea, Schandeler, Sarah, Vogel, Marco M. E., Ruf, Juri, Mix, Michael, Kirste, Simon, Ceci, Francesco, Fanti, Stefano, Lanzafame, Helena, Serani, Francesca, Gratzke, Christian, Sigle, August, Combs, Stephanie E., Bernhardt, Denise, Gschwend, Juergen E., Buchner, Josef A., Trapp, Christian, Belka, Claus, Bartenstein, Peter, Unterrainer, Lena, Unterrainer, Marcus, Eiber, Matthias, Nekolla, Stephan G., Schiller, Kilian, Grosu, Anca L., Schmidt-Hegemann, Nina-Sophie, Zamboglou, Constantinos, and Peeken, Jan C.

Published
2022
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15. Genomic Classifiers in Personalized Prostate Cancer Radiation Therapy Approaches: A Systematic Review and Future Perspectives Based on International Consensus

Author

Spohn, Simon K.B., Draulans, Cédric, Kishan, Amar U., Spratt, Daniel, Ross, Ashley, Maurer, Tobias, Tilki, Derya, Berlin, Alejandro, Blanchard, Pierre, Collins, Sean, Bronsert, Peter, Chen, Ronald, Pra, Alan Dal, de Meerleer, Gert, Eade, Thomas, Haustermans, Karin, Hölscher, Tobias, Höcht, Stefan, Ghadjar, Pirus, Davicioni, Elai, Heck, Matthias, Kerkmeijer, Linda G.W., Kirste, Simon, Tselis, Nikolaos, Tran, Phuoc T., Pinkawa, Michael, Pommier, Pascal, Deltas, Constantinos, Schmidt-Hegemann, Nina-Sophie, Wiegel, Thomas, Zilli, Thomas, Tree, Alison C., Qiu, Xuefeng, Murthy, Vedang, Epstein, Jonathan I., Graztke, Christian, Gao, Xin, Grosu, Anca L., Kamran, Sophia C., and Zamboglou, Constantinos

Published
2023
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17. DEGRO practical guideline for central nervous system radiation necrosis part 2: treatment

Author

Bernhardt, Denise, König, Laila, Grosu, Anca-L., Rieken, Stefan, Krieg, Sandro M., Wick, Wolfgang, Wiestler, Benedikt, Schmidt-Graf, Friederike, Sahm, Felix, Gempt, Jens, Meyer, Bernhard, Krause, Bernd J., Petersen, Cordula, Fietkau, Rainer, Thomas, Michael, Giordano, Frank, Wittig-Sauerwein, Andrea, Debus, Jürgen, Tabatabai, Ghazaleh, Hau, Peter, Steinbach, Joachim, and Combs, Stephanie E.

Published
2022
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18. Strahlentherapie und Immuntherapie

Author

Gaipl, Udo S., primary, Grosu, Anca L., additional, Frey, Benjamin, additional, Rückert, Michael, additional, Schäfer, Henning, additional, and Popp, Ilinca, additional

Published
2023
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19. Improved Oxygenation of Human Skin, Subcutis and Superficial Cancers Upon Mild Hyperthermia Delivered by WIRA-Irradiation

Author

Thomsen, Andreas R., Saalmann, Michael R., Nicolay, Nils H., Grosu, Anca-L, Vaupel, Peter, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Scholkmann, Felix, editor, LaManna, Joseph, editor, and Wolf, Ursula, editor

Published
2022
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22. PSMA-PET- and MRI-Based Focal Dose Escalated Radiation Therapy of Primary Prostate Cancer: Planned Safety Analysis of a Nonrandomized 2-Armed Phase 2 Trial (ARO2020-01)

Author

Zamboglou, Constantinos, Spohn, Simon K.B., Ruf, Juri, Benndorf, Matthias, Gainey, Mark, Kamps, Marius, Jilg, Cordula, Gratzke, Christian, Adebahr, Sonja, Schmidtmayer-Zamboglou, Barbara, Mix, Michael, Bamberg, Fabian, Zschaeck, Sebastian, Ghadjar, Pirus, Baltas, Dimos, and Grosu, Anca L.

Published
2022
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25. Feasibility, pitfalls and results of a structured concept-development phase for a randomized controlled phase III trial on radiotherapy in primary prostate cancer patients

Author

Spohn, S. K. B., Adebahr, S., Huber, M., Jenkner, C., Wiehle, R., Nagavci, B., Schmucker, C., Carl, E. G., Chen, R. C., Weber, W. A., Mix, M., Rühle, A., Sprave, T., Nicolay, N. H., Gratzke, C., Benndorf, M., Wiegel, T., Weis, J., Baltas, D., Grosu, A. L., and Zamboglou, C.

Published
2022
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30. Integration of radiation oncology teaching in medical studies by German medical faculties due to the new licensing regulations: An overview and recommendations of the consortium academic radiation oncology of the German Society for Radiation Oncology (DEGRO)

Author

Dapper, H., Belka, C., Bock, F., Budach, V., Budach, W., Christiansen, H., Debus, J., Distel, L., Dunst, J., Eckert, F., Eich, H., Eicheler, W., Engenhart-Cabillic, R., Fietkau, R., Fleischmann, D. F., Frerker, B., Giordano, F. A., Grosu, A. L., Herfarth, K., Hildebrandt, G., Kaul, D., Kölbl, O., Krause, M., Krug, D., Martin, D., Matuschek, C., Medenwald, D., Nicolay, N. H., Niewald, M., Oertel, M., Petersen, C., Pohl, F., Raabe, A., Rödel, C., Rübe, C., Schmalz, C., Schmeel, L. C., Steinmann, D., Stüben, G., Thamm, R., Vordermark, D., Vorwerk, H., Wiegel, T., Zips, D., and Combs, S. E.

Published
2022
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32. Quantification of Tumor Oxygenation Based on FMISO PET: Influence of Location and Oxygen Level of the Well-Oxygenated Reference Region

Author

Lazzeroni, M., Toma-Dasu, I., Ureba, A., Schiavo, F., Wiedenmann, N., Bunea, H., Thomann, B., Baltas, D., Mix, M., Stoykow, C., Sörensen, A., Grosu, A. L., Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Lambris, John D., Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Ryu, Pan-Dong, editor, LaManna, Joseph C., editor, Harrison, David K., editor, and Lee, Sang-Suk, editor

Published
2020
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33. Molecular Imaging in Photon Radiotherapy

Author

Fennell, Jamina Tara, Gkika, Eleni, Grosu, Anca L., Krämer, Alwin, Series Editor, Lu, Jiade J., Series Editor, Schober, Otmar, editor, Kiessling, Fabian, editor, and Debus, Jürgen, editor

Published
2020
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35. Prostate-specific Membrane Antigen Positron Emission Tomography–detected Oligorecurrent Prostate Cancer Treated with Metastases-directed Radiotherapy: Role of Addition and Duration of Androgen Deprivation

Author

Kroeze, Stephanie G.C., Henkenberens, Christoph, Schmidt-Hegemann, Nina Sophie, Vogel, Marco M.E., Kirste, Simon, Becker, Jessica, Burger, Irene A., Derlin, Thorsten, Bartenstein, Peter, Eiber, Matthias, Mix, Michael, la Fougère, Christian, Christiansen, Hans, Belka, Claus, Combs, Stephanie E., Grosu, Anca L., Müller, Arndt Christian, and Guckenberger, Matthias

Published
2021
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36. Correction to: Value of PET imaging for radiation therapy

Author

Lapa, Constantin, Nestle, Ursula, Albert, Nathalie L., Baues, Christian, Beer, Ambros, Buck, Andreas, Budach, Volker, Bütof, Rebecca, Combs, Stephanie E., Derlin, Thorsten, Eiber, Matthias, Fendler, Wolfgang P., Furth, Christian, Gani, Cihan, Gkika, Eleni, Grosu, Anca-L., Henkenberens, Christoph, Ilhan, Harun, Löck, Steffen, Marnitz-Schulze, Simone, Miederer, Matthias, Mix, Michael, Nicolay, Nils H., Niyazi, Maximilian, Pöttgen, Christoph, Rödel, Claus M., Schatka, Imke, Schwarzenboeck, Sarah M., Todica, Andrei S., Weber, Wolfgang, Wegen, Simone, Wiegel, Thomas, Zamboglou, Constantinos, Zips, Daniel, Zöphel, Klaus, Zschaeck, Sebastian, Thorwarth, Daniela, and Troost, Esther G. C.

Published
2022
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38. Evaluating the impact of a rigid and a deformable registration method of pre-treatment images for hypoxia-based dose painting

Author

Lazzeroni, M., Ureba, A., Rosenberg, Viktor, Schäfer, H., Rühle, A., Baltas, D., Toma-Dasu, I., Grosu, A. L., Lazzeroni, M., Ureba, A., Rosenberg, Viktor, Schäfer, H., Rühle, A., Baltas, D., Toma-Dasu, I., and Grosu, A. L.

Abstract

Purpose: To assess the impact of rigid and deformable image registration methods (RIR, DIR) on the outcome of a hypoxia-based dose painting strategy. Materials and methods: Thirty head and neck cancer patients were imaged with [18F]FMISO-PET/CT before radiotherapy. [18F]FMISO-PET/CT images were registered to the planning-CT by RIR or DIR. The [18F]FMISO uptake was converted into oxygen partial pressure (pO2) maps. Hypoxic Target Volumes were contoured on pO2 maps for the deformed (HTVdef) and non-deformed (HTV) cases. A dose escalation strategy by contours, aiming at 95 % tumour control probability (TCP), was applied. HTVs were characterised based on geometry-related metrics, the underlying pO2 distribution, and the dose boost level. A dosimetric and radiobiological evaluation of selected treatment plans made considering RIR and DIR was performed. Moreover, the TCP of the RIR dose distribution was evaluated when considering the deformed [18F]FMISO-PET image as an indicator of the actual target radiosensitivity to determine the potential impact of an unalignment. Results: Statistically significant differences were found between HTV and HTVdef for volume-based metrics and underlying pO2 distribution. Eight out of nine treatment plans for HTV and HTVdef showed differences on the level 10 %/3 mm on a gamma analysis. The TCP difference, however, between RIR and the case when the RIR dose distribution was used with the deformed radiosensitivity map was below 2 pp. Conclusions: Although the choice of the CTplan-to-PET registration method pre-treatment impacts the HTV localisation and morphology and the corresponding dose distribution, it negligibly affects the TCP in the proposed dose escalation strategy by contours., QC 20240531

Published
2024
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40. Correlating Dose Variables with Local Tumor Control in Stereotactic Body Radiation Therapy for Early-Stage Non-Small Cell Lung Cancer: A Modeling Study on 1500 Individual Treatments

Author

Klement, Rainer J., Sonke, Jan-Jakob, Allgäuer, Michael, Andratschke, Nicolaus, Appold, Steffen, Belderbos, José, Belka, Claus, Blanck, Oliver, Dieckmann, Karin, Eich, Hans T., Mantel, Frederick, Eble, Michael, Hope, Andrew, Grosu, Anca L., Nevinny-Stickel, Meinhard, Semrau, Sabine, Sweeney, Reinhart A., Hörner-Rieber, Juliane, Werner-Wasik, Maria, Engenhart-Cabillic, Rita, Ye, Hong, Grills, Inga, and Guckenberger, Matthias

Published
2020
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42. Imaging-based target volume reduction in chemoradiotherapy for locally advanced non-small-cell lung cancer (PET-Plan): a multicentre, open-label, randomised, controlled trial

Author

Grosu, A L, Weber, W, Meyer, P, Hoffmanns, H, Nestle, U, Aurisch, R, Schäfer, W, Hehr, T, Eschmann, S M, Dornoff, W, Siekmeyer, B, Trampert, L, Gademann, G, Brunner, T, Amthauer, A, Ricke, J, Pech, M, Rübe, C, Kirsch, C M, Ezzidin, S, Schmidberger, H, Schreckenberger, M, Bamberg, M, Zips, D, Bares, R, La Fougere, C, Budach, V, Brenner, W, Beck, M, Freiherr von Gumppenberg, R, Aebersold, D, Krause, T, Feldmann, H J, Hertel, A, Stüben, G, Sciuk, J, Annweiler, H, Holl, G, Oehler, W, Schlöcker, I, Baum, R, Kimmig, B, Dunst, J, Henze, E, Lützen, U, Schwaiger, M, Strehle, K, Alberti, W, Piroth, M, Tosch, M, Pötter, R, Widder, J, Herold, C, Freund, U, Momm, F, Sautter-Bihl, M L, Tatsch, K, Hildebrandt, G, Krause, B, Nestle, Ursula, Schimek-Jasch, Tanja, Kremp, Stephanie, Schaefer-Schuler, Andrea, Mix, Michael, Küsters, Andreas, Tosch, Marco, Hehr, Thomas, Eschmann, Susanne Martina, Bultel, Yves-Pierre, Hass, Peter, Fleckenstein, Jochen, Thieme, Alexander, Stockinger, Marcus, Dieckmann, Karin, Miederer, Matthias, Holl, Gabriele, Rischke, H Christian, Gkika, Eleni, Adebahr, Sonja, König, Jochem, and Grosu, Anca-Ligia

Published
2020
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43. Estimation of the α/β ratio of non-small cell lung cancer treated with stereotactic body radiotherapy

Author

Klement, Rainer J., Sonke, Jan-Jakob, Allgäuer, Michael, Andratschke, Nicolaus, Appold, Steffen, Belderbos, José, Belka, Claus, Dieckmann, Karin, Eich, Hans T., Flentje, Michael, Grills, Inga, Eble, Michael, Hope, Andrew, Grosu, Anca L., Semrau, Sabine, Sweeney, Reinhart A., Hörner-Rieber, Juliane, Werner-Wasik, Maria, Engenhart-Cabillic, Rita, Ye, Hong, and Guckenberger, Matthias

Published
2020
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44. Radiomics-based prediction of local control in patients with brain metastases following postoperative stereotactic radiotherapy

Author

Buchner, Josef A., primary, Kofler, Florian, additional, Mayinger, Michael, additional, Christ, Sebastian M., additional, Brunner, Thomas B., additional, Wittig, Andrea, additional, Menze, Bjoern, additional, Zimmer, Claus, additional, Meyer, Bernhard, additional, Guckenberger, Matthias, additional, Andratschke, Nicolaus, additional, El Shafie, Rami A., additional, Debus, Jürgen, additional, Rogers, Susanne, additional, Riesterer, Oliver, additional, Schulze, Katrin, additional, Feldmann, Horst J., additional, Blanck, Oliver, additional, Zamboglou, Constantinos, additional, Ferentinos, Konstantinos, additional, Bilger-Zähringer, Angelika, additional, Grosu, Anca L., additional, Wolff, Robert, additional, Piraud, Marie, additional, Eitz, Kerstin A., additional, Combs, Stephanie E., additional, Bernhardt, Denise, additional, Rueckert, Daniel, additional, Wiestler, Benedikt, additional, and Peeken, Jan C., additional

Published
2024
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48. The impact of the co-registration technique and analysis methodology in comparison studies between advanced imaging modalities and whole-mount-histology reference in primary prostate cancer

Author

Zamboglou, Constantinos, Kramer, Maria, Kiefer, Selina, Bronsert, Peter, Ceci, Lara, Sigle, August, Schultze-Seemann, Wolfgang, Jilg, Cordula A., Sprave, Tanja, Fassbender, Thomas F., Nicolay, Nils H., Ruf, Juri, Benndorf, Matthias, Grosu, Anca L., and Spohn, Simon K. B.

Published
2021
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50. [68Ga-]PSMA-11 PET/CT and multiparametric MRI for gross tumor volume delineation in a slice by slice analysis with whole mount histopathology as a reference standard – Implications for focal radiotherapy planning in primary prostate cancer

Author

Bettermann, Alisa S., Zamboglou, Constantinos, Kiefer, Selina, Jilg, Cordula A., Spohn, Simon, Kranz-Rudolph, Jasmin, Fassbender, Thomas F., Bronsert, Peter, Nicolay, Nils H., Gratzke, Christian, Bock, Michael, Ruf, Juri, Benndorf, Matthias, and Grosu, Anca L.

Published
2019
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