215 results on '"Grotenhuis, Brechtje A."'
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2. MRI anatomy of the rectum: key concepts important for rectal cancer staging and treatment planning
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Bogveradze, Nino, Snaebjornsson, Petur, Grotenhuis, Brechtje A., van Triest, Baukelien, Lahaye, Max J., Maas, Monique, Beets, Geerard L., Beets-Tan, Regina G. H., and Lambregts, Doenja M. J.
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- 2023
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3. Imaging Photoplethysmography for Noninvasive Anastomotic Perfusion Assessment in Intestinal Surgery
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van der Stel, Stefan D., Lai, Marco, Groen, Harald C., Witteveen, Mark, Kuhlmann, Koert F.D., Grotenhuis, Brechtje A., Kok, Niels F.M., van Gastel, Mark, Hendriks, Benno H.W., and Ruers, Theo J.M.
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- 2023
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4. Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort
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Greijdanus, Nynke G., Wienholts, Kiedo, Ubels, Sander, Talboom, Kevin, Hannink, Gerjon, Wolthuis, Albert, de Lacy, Francisco B., Lefevre, Jérémie H., Solomon, Michael, Frasson, Matteo, Rotholtz, Nicolas, Denost, Quentin, Perez, Rodrigo O., Konishi, Tsuyoshi, Panis, Yves, Rutegård, Martin, Hompes, Roel, Rosman, Camiel, van Workum, Frans, Tanis, Pieter J., de Wilt, Johannes H.W., Bremers, Andreas J.A., Ferenschild, Floris T., de Vriendt, Stefanie, D’Hoore, André, Bislenghi, Gabriele, Farguell, Jordi, Lacy, Antonio M., Atienza, Paula González, van Kessel, Charlotte S., Parc, Yann, Voron, Thibault, Collard, Maxime K., Muriel, Jorge Sancho, Cholewa, Hannia, Mattioni, Laura A., Frontali, Alice, Polle, Sebastiaan W., Polat, Fatih, Obihara, Ndidi J., Vailati, Bruna B., Kusters, Miranda, Tuynmann, Jurriaan B., Hazen, Sanne J.A., Grüter, Alexander A.J., Amano, Takahiro, Fujiwara, Hajime, Salomon, Mario, Ruiz, Hernán, Gonzalez, Ricardo, Estefanía, Diego, Avellaneda, Nicolas, Carrie, Augusto, Santillan, Mateo, Pantoja Pachajoa, Diana A., Parodi, Matias, Gielis, Manuel, Binder, Alf-Dorian, Gürtler, Thomas, Riedl, Peter, Badiani, Sarit, Berney, Christophe, Morgan, Matthew, Hollington, Paul, da Silva, Nigel, Nair, Gavin, Ho, Yiu M., Lamparelli, Michael, Kapadia, Raj, Kroon, Hidde M., Dudi-Venkata, Nagendra N., Liu, Jianliang, Sammour, Tarik, Flamey, Nicolas, Pattyn, Paul, Chaoui, Ahmed, Vansteenbrugge, Louis, van den Broek, Nathalie E.J., Vanclooster, Patrick, de Gheldere, Charles, Pletinckx, Pieter, Defoort, Barbara, Dewulf, Maxime, Slavchev, Mihail, Belev, Nikolay, Atanasov, Boyko, Krastev, Panche, Sokolov, Manol, Maslyankov, Svilen, Gribnev, Petar, Pavlov, Vasil, Ivanov, Tsvetomir, Karamanliev, Martin, Filipov, Emil, Tonchev, Pencho, Aigner, Felix, Mitteregger, Martin, Allmer, Caterina, Seitinger, Gerald, Colucci, Nicola, Buchs, Nicolas, Ris, Frédéric, Toso, Christian, Gialamas, Eleftherios, Vuagniaux, Aurélie, Chautems, Roland, Sauvain, Marc-Olivier, Daester, Silvio, von Flüe, Markus, Guenin, Marc-Olivier, Taha-Mehlitz, Stephanie, Hess, Gabriel F., Martínek, Lubomír, Skrovina, Matej, Machackova, Maria, Benčurik, Vladimir, Uluk, Deniz, Pratschke, Johann, Dittrich, Luca S., Guel-Klein, Safak, Perez, Daniel, Grass, Julia-Kristin, Melling, Nathaniel, Mueller, Simone, Iversen, Lene H., Eriksen, Jacob D., Baatrup, Gunnar, Al-Najami, Issam, Bjørsum-Meyer, Thomas, Teras, Jüri, Teras, Roland M., Monib, Fatma A., Abu Elnga Ahmed, Nagm Eldin, Alkady, Eithar, Ali, Ahmed K., Khedr, Gehan Abd Elatti, Abdelaal, Ahmed Samir, Bassyouni Ashoush, Fouad M., Ewedah, Moataz, Elshennawy, Eslam M., Hussein, Mohamed, Fernández-Martínez, Daniel, García-Flórez, Luis J., Fernández-Hevia, María, Suárez-Sánchez, Aida, del Hoyo Aretxabala, Izaskun, Docampo, Iria Losada, Zabala, Jesús Gómez, Tejedor, Patricia, Morales Bernaldo de Quirós, Javier T., Quiroga, Ignacio Bodega, Navarro-Sánchez, Antonio, Darias, Iván Soto, Fernández, Cristina López, de La Cruz Cuadrado, Cristina, Sánchez-Guillén, Luis, López-Rodríguez-Arias, Francisco, Soler-Silva, Álvaro, Arroyo, Antonio, Bernal-Sprekelsen, Juan C., Gómez-Abril, Segundo Á., Gonzálvez, Paula, Torres, María T., Sánchez, Teresa Rubio, Antona, Francisco Blanco, Sánchez Lara, Juan E., Alcázar Montero, José A., Fernández-Martínez, Daniel, García-Flórez, Luis J., Fernández-Hevia, María, Suárez-Sánchez, Aida, Colás-Ruiz, Enrique, Tasende-Presedo, Marta M., Fernández-Hurtado, Ignacio, Cifuentes-Ródenas, José A., Suárez, Marta Castro, Losada, Manuel, Hernández, Miguel, Alonso, Alfredo, Diéguez, Beatriz, Serralta, Daniel, Medina Quintana, Rita E., Gil Lopez, Jose M., Pinto, Francisca Lima, Nieto-Moreno, Elena, Bonito, Alba Correa, Santacruz, Carlos Cerdán, Marcos, Elena Bermejo, Septiem, Javier García, Calero-Lillo, Aránzazu, Alanez-Saavedra, Javier, Muñoz-Collado, Salvador, López-Lara, Manuel, Martínez, María Labalde, Herrero, Eduardo Ferrero, Borda, Francisco Javier García, Villar, Óscar García, Escartín, Jorge, Blas, Juan L., Ferrer, Rocío, Egea, Jorge García, Rodríguez-Infante, Antonio, Mínguez-Ruiz, Germán, Carreño-Villarreal, Guillermo, Pire-Abaitua, Gerardo, Dziakova, Jana, Rodríguez, Carlos Sáez-Cazallas, Pizarro Aranda, María J., Muguerza Huguet, José M., Borda-Arrizabalaga, Nerea, Enriquez-Navascués, José M., Echaniz, Garazi Elorza, Ansorena, Yolanda Saralegui, Estaire-Gómez, Mercedes, Martínez-Pinedo, Carlos, Barbero-Valenzuela, Alejandro, Ruíz-García, Pablo, Kraft, Miquel, Gómez-Jurado, María J., Pellino, Gianluca, Espín-Basany, Eloy, Cotte, Eddy, Panel, Nathalie, Goutard, Claire-Angéline, deÁngelis, Nicola, Lauka, Lelde, Shaikh, Shafaque, Osborne, Laura, Ramsay, George, Nichita, Vladimir-Ion, Bhandari, Santosh, Sarmah, Panchali, Bethune, Rob M., Pringle, Heather C.M., Massey, Lisa, Fowler, George E., Hamid, Hytham K.S., de Simone, Belinda D., Kynaston, James, Bradley, Nicholas, Stienstra, Roxane M., Gurjar, Shashank, Mukherjee, Tanmoy, Chandio, Ashfaq, Ahmed, Safia, Singh, Baljit, Runau, 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J., Connelly, Tara M., Neary, Peter, Ryan, Jessica, McCullough, Peter, Al-Juaifari, Maytham A., Hammoodi, Hayder, Abbood, Ali Hashim, Calabrò, Marcello, Muratore, Andrea, Terra, Antonio La, Farnesi, Francesca, Feo, Carlo V., Fabbri, Nicolò, Pesce, Antonio, Fazzin, Marta, Roscio, Francesco, Clerici, Federico, Lucchi, Andrea, Vittori, Laura, Agostinelli, Laura, Ripoli, Maria Cristina, Sambucci, Daniele, Porta, Andrea, Sinibaldi, Giovanni, Crescentini, Giacomo, larcinese, Antonella, Picone, Emanuele, Persiani, Roberto, Biondi, Alberto, Pezzuto, Roberto, Lorenzon, Laura, Rizzo, Gianluca, Coco, Claudio, D’Agostino, Luca, Spinelli, Antonino, Sacchi, Matteo M., Carvello, Michele, Foppa, Caterina, Spinelli, Antonino, Sacchi, Matteo M., Carvello, Michele, Foppa, Caterina, Maroli, Annalisa, Palini, Gian M., Garulli, Gianluca, Zanini, Nicola, Delrio, Paolo, Rega, Daniela, Carbone, Fabio, Aversano, Alessia, Pirozzolo, Giovanni, Recordare, Alfonso, DʼAlimonte, Lucrezia, Vignotto, Chiara, Corbellini, Carlo, Sampietro, Gianluca M., Lorusso, Leonardo, Manzo, Carlo A., Ghignone, Federico, Ugolini, Giampaolo, Montroni, Isacco, Pasini, Franceso, Pasini, Francesco, Ballabio, Michele, Bisagni, Pietro, Armao, Francesca T., Longhi, Marco, Ghazouani, Omar, Galleano, Raffaele, Tamini, Nicolò, Oldani, Massimo, Nespoli, Luca, Picciariello, Arcangelo, Altomare, Donato F., Tomasicchio, Giovanni, Lantone, Giuliano, Catena, Fausto, Giuffrida, Mario, Annicchiarico, Alfredo, Perrone, Gennaro, Grossi, Ugo, Santoro, Giulio A., Zanus, Giacomo, Iacomino, Alessandro, Novello, Simone, Passuello, Nicola, Zucchella, Martino, Puca, Lucia, deGiuli, Maurizio, Reddavid, Rossella, Scabini, Stefano, Aprile, Alessandra, Soriero, Domenico, Fioravanti, Emanuela, Rottoli, Matteo, Romano, Angela, Tanzanu, Marta, Belvedere, Angela, Mariani, Nicolò M., Ceretti, Andrea P., Opocher, Enrico, Gallo, Gaetano, Sammarco, Giuseppe, de Paola, Gilda, Pucciarelli, Salvatore, Marchegiani, Francesco, Spolverato, Gaya, Buzzi, Gianluca, Di Saverio, Salomone, Meroni, Paola, Parise, Cristiano, Bottazzoli, Elisa I., Lapolla, Pierfrancesco, Brachini, Gioia, Cirillo, Bruno, Mingoli, Andrea, Sica, Giuseppe, Siragusa, Leandro, Bellato, Vittoria, Cerbo, Daniele, de Pasqual, Carlo A., de Manzoni, Giovanni, di Cosmo, Maria A., Alrayes, Bourhan M.H., Qandeel, Mahmoud W. M., Hani, Mohammad Bani, Rabadi, Alexander, el Muhtaseb, Mohammad S., Abdeen, Basel, Karmi, Fahed, Žilinskas, Justas, Latkauskas, Tadas, Tamelis, Algimantas, Pikūnienė, Ingrida, Šlenfuktas, Vygintas, Poskus, Tomas, Kryzauskas, Marius, Jakubauskas, Matas, Mikalauskas, Saulius, Jakubauskiene, Lina, Hassan, Soha Y., Altrabulsi, Amani, Abdulwahed, Eman, Ghmagh, Reem, Deeknah, Abdulqudus, Alshareea, Entisar, Elhadi, Muhammed, Abujamra, Saleh, Msherghi, Ahmed A., Tababa, Osama W.E., Majbar, Mohammed A., Souadka, Amine, Benkabbou, Amine, Mohsine, Raouf, Echiguer, Sabrillah, Moctezuma-Velázquez, Paulina, Salgado-Nesme, Noel, Vergara-Fernández, Omar, Sainz-Hernández, Juan C., Alvarez-Bautista, Francisco E., Zakaria, Andee D., Zakaria, Zaidi, Wong, Michael P.K., Ismail, Razif, Ibrahim, Aini F., Abdullah, Nik A.N., Julaihi, Rokayah, Bhat, Sameer, OʼGrady, Greg, Bissett, Ian, Lamme, Bas, Musters, Gijsbert D., Dinaux, Anne M., Grotenhuis, Brechtje A., Steller Arend G.J. Aalbers, Ernst J., Leeuwenburgh, Marjolein M., Rutten, Harm J.T., Burger, Jacobus W.A., Bloemen, Johanne G., Ketelaers, Stijn H.J., Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, Talsma, Aaldert K., Scheurink, Lieke, van Praagh, Jasper B., Segelman, Josefin, Nygren, Jonas, Anderin, Kajsa, Tiefenthal, Marit, de Andrés, Beatriz, Beltrán de Heredia, Juan P., Vázquez, Andrea, Gómez, Tania, Golshani, Parisa, Kader, Rawaz, Mohamed, Abudi, Westerterp, Marinke, Marinelli, Andreas, Niemer, Quirine, Doornebosch, Pascal G., Shapiro, Joël, Vermaas, Maarten, de Graaf, Eelco J.R., van Westreenen, Hendrik L., Zwakman, Marije, van Dalsen, Annette D., Vles, Wouter J., Nonner, Joost, Toorenvliet, Boudewijn R., Janssen, Paul T.J., Verdaasdonk, Emiel G.G., Amelung, Femke J., Peeters Renu R. Bahadoer, Koen C.M.J., Holman, Fabian A., Heemskerk, Jeroen, Vosbeek, Noortje, Leijtens, Jeroen W.A., Taverne, Sophie B.M., Heijnen, Bob H.M., El-Massoudi, Youssef, de Groot-van Veen, Irene, Hoff, Christiaan, Jou-Valencia, Daniela, Consten, Esther C.J., Burghgraef, Thijs A., Geitenbeek, Ritch, Hulshof, Lorenzo G.W.L., Slooter, Gerrit D., Reudink, Muriël, Bouvy, Nicole D., Wildeboer, Aurelia C. L., Verstappen, Sonja, Pennings, Alexander J., van den Hengel, Berber, Wijma, Allard G., de Haan, Jael, de Nes, Lindsey C.F., Heesink, Vera, Karsten, Tom, Heidsma, Charlotte M., Koemans, Willem J., Dekker, Jan-Willem T., van der Zijden, Charlène J., Roos, Daphne, Demirkiran, Ahmet, van der Burg, Sjirk, Oosterling, Steven J., Hoogteijling, Tijs J., Wiering, Bastiaan, Smeeing, Diederik P.J., Havenga, Klaas, Lutfi, Hamid, Consten, Esther C.J., Tsimogiannis, Konstantinos, Sköldberg, Filip, Folkesson, Joakim, den Boer, Frank, van Schaik, Ted G., van Gerven, Pieter, Sietses, Colin, Hol, Jeroen C., Boerma, Evert-Jan G., Creemers, Davy M.J., Schultz, Johannes K., Frivold, Tone, Riis, Rolf, Gregussen, Hilde, Busund, Sondre, Sjo, Ole H., Gaard, Maria, Krohn, Nina, Ersryd, Amanda L., Leung, Edmund, Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, Sultan, Hytham, Hajjaj, Baraa Nabil, Alhisi, Ahmed Jehad, Khader, Ahmed A.E., Mendes, Ana Filipa Dias, Semião, Miguel, Faria, Luis Queiroz, Azevedo, Constança, da Costa Devesa, Helena M., Martins, Sónia Fortuna, Rodrigues Jarimba, Aldo M., Ribeiro Marques, Sónia M., Ferreira, Rita Marques, Oliveira, António, Ferreira, Cátia, Pereira, Ricardo, Surlin, Valeriu M., Graure, Giorgiana M., Ramboiu, Stefan Patrascu Sandu D., Negoi, Ionut, Ciubotaru, Cezar, Stoica, Bogdan, Tanase, Ioan, Stoica, Bogdan, Ciubotaru, Cezar, Negoita, Valentina M., Florea, Sabrina, Macau, Florin, Vasile, Mihai, Stefanescu, Victor, Dimofte, Gabriel-Mihail, Luncă, Sorinel, Roată, Cristian-Ene, Mu[Latin Small Letter s with comma below]ină, Ana-Maria, Garmanova, Tatiana, Agapov, Mikhail N., Markaryan, Daniil G., Eduard, Galliamov, Yanishev, Alexey, Abelevich, Alexander, Bazaev, Andrey, Rodimov, Sergey V., Filimonov, Victor B., Melnikov, Andrey A., Suchkov, Igor A., Drozdov, EvgeniyS., Kostromitskiy, Dmitriy N., Sjöström, Olle, Matthiessen, Peter, Baban, Bayar, Gadan, Soran, Jadid, Kaveh Dehlaghi, Staffan, Maria, Park, Jennifer M., Rydbeck, Daniel, Lydrup, Marie-Louise, Buchwald, Pamela, Jutesten, Henrik, Darlin, Lotten, Lindqvist, Ebba, Nilsson, Karl, Larsson, Per-Anders, Jangmalm, Staffan, Košir, Jurij A., Tomažič, Aleš, Grosek, Jan, Božič, Tajda Košir, Zazo, Aya, Zazo, Rama, Fares, Hala, Ayoub, Kusay, Niazi, Ammar, Mansour, Ali, Abbas, Ayman, Tantoura, Mohammad, Hamdan, Alaa, Hassan, Naya, Hasan, Bassam, Saad, Ahmad, Sebai, Amine, Haddad, Anis, Maghrebi, Houcine, Kacem, Montasser, Yalkın, Ömer, Samsa, Mehmet Veysi, Atak, İbrahim, Balci, Bengi, Haberal, Elifcan, Dogan, Lütfi, Gecim, Ibrahim E., Akyol, Cihangir, Koc, Mehmet A., Sivrikoz, Emre, Piyadeoğlu, Deniz, Larkin, John O., avanagh, Dara O., Sökmen, Selman, Bişgin, Tayfun, Günenç, Erşan, Güzel, Melek, Leventoğlu, Sezai, Yüksel, Osman, Kozan, Ramazan, Göbüt, Hüseyin, Cengiz, Fevzi, Erdinc, Kemal, Acar, Nihan Coşgun, Kamer, Erdinc, Özgür, İlker, Aydın, Oguzhan, Keskin, Metin, Bulut, Mehmet Türker, Kulle, Cemil B., Kara, Yasin, Sıbıç, Osman, Özata, İbrahim H., Buğra, Dursun, Balık, Emre, Kulle, Cemil B., Çakır, Murat, Alhardan, Anas, Colak, Elif, CiftciEngin Aybar, Ahmet B., Sari, Ahmet Can, Atici, Semra Demirli, Kaya, Tayfun, Dursun, Ayberk, Calik, Bulent, Özkan, Ömer Faruk, Ülgür, Hanife Şeyda, Düzgün, Özgül, Monson, John, George, Sarah, Woods, Kayla, Al-Eryani, Fatima, Albakry, Rudaina, Coetzee, Emile, Boutall, Adam, Herman, Ayesiga, Warden, Claire, Mugla, Naser, Forgan, Tim, Mia, Imraan, and Lambrechts, Anton
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- 2023
- Full Text
- View/download PDF
5. What To Do With Suspected Nodal Regrowth on MRI During Follow-Up in an Organ Preservation Approach for Rectal Cancer?
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Geubels, Barbara M., Maas, Monique, Beets, Geerard L., and Grotenhuis, Brechtje A.
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- 2024
- Full Text
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6. Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair–Deficient Colon Cancer
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Chalabi, Myriam, primary, Verschoor, Yara L., additional, Tan, Pedro Batista, additional, Balduzzi, Sara, additional, Van Lent, Anja U., additional, Grootscholten, Cecile, additional, Dokter, Simone, additional, Büller, Nikè V., additional, Grotenhuis, Brechtje A., additional, Kuhlmann, Koert, additional, Burger, Jacobus W., additional, Huibregtse, Inge L., additional, Aukema, Tjeerd S., additional, Hendriks, Eduard R., additional, Oosterling, Steven J., additional, Snaebjornsson, Petur, additional, Voest, Emile E., additional, Wessels, Lodewyk F., additional, Beets-Tan, Regina G., additional, Van Leerdam, Monique E., additional, Schumacher, Ton N., additional, van den Berg, José G., additional, Beets, Geerard L., additional, and Haanen, John B., additional
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- 2024
- Full Text
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7. Neoadjuvant Immunotherapy in Locally Advanced Mismatch Repair-Deficient Colon Cancer
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Chalabi, Myriam, Verschoor, Yara L., Tan, Pedro Batista, Balduzzi, Sara, Van Lent, Anja U., Grootscholten, Cecile, Dokter, Simone, Büller, Nikè V., Grotenhuis, Brechtje A., Kuhlmann, Koert, Burger, Jacobus W., Huibregtse, Inge L., Aukema, Tjeerd S., Hendriks, Eduard R., Oosterling, Steven J., Snaebjornsson, Petur, Voest, Emile E., Wessels, Lodewyk F., Beets-Tan, Regina G., Van Leerdam, Monique E., Schumacher, Ton N., van den Berg, José G., Beets, Geerard L., Haanen, John B., Chalabi, Myriam, Verschoor, Yara L., Tan, Pedro Batista, Balduzzi, Sara, Van Lent, Anja U., Grootscholten, Cecile, Dokter, Simone, Büller, Nikè V., Grotenhuis, Brechtje A., Kuhlmann, Koert, Burger, Jacobus W., Huibregtse, Inge L., Aukema, Tjeerd S., Hendriks, Eduard R., Oosterling, Steven J., Snaebjornsson, Petur, Voest, Emile E., Wessels, Lodewyk F., Beets-Tan, Regina G., Van Leerdam, Monique E., Schumacher, Ton N., van den Berg, José G., Beets, Geerard L., and Haanen, John B.
- Abstract
BACKGROUND: Mismatch repair-deficient (dMMR) tumors can be found in 10 to 15% of patients with nonmetastatic colon cancer. In these patients, the efficacy of chemotherapy is limited. The use of neoadjuvant immunotherapy has shown promising results, but data from studies of this approach are limited. METHODS: We conducted a phase 2 study in which patients with nonmetastatic, locally advanced, previously untreated dMMR colon cancer were treated with neoadjuvant nivolumab plus ipilimumab. The two primary end points were safety, defined by timely surgery (i.e., =2-week delay of planned surgery owing to treatment-related toxic events), and 3-year disease-free survival. Secondary end points included pathological response and results of genomic analyses. RESULTS: Of 115 enrolled patients, 113 (98%; 97.5% confidence interval [CI], 93 to 100) underwent timely surgery; 2 patients had surgery delayed by more than 2 weeks. Grade 3 or 4 immune-related adverse events occurred in 5 patients (4%), and none of the patients discontinued treatment because of adverse events. Among the 111 patients included in the efficacy analysis, a pathological response was observed in 109 (98%; 95% CI, 94 to 100), including 105 (95%) with a major pathological response (defined as =10% residual viable tumor) and 75 (68%) with a pathological complete response (0% residual viable tumor). With a median follow-up of 26 months (range, 9 to 65), no patients have had recurrence of disease. CONCLUSIONS: In patients with locally advanced dMMR colon cancer, neoadjuvant nivolumab plus ipilimumab had an acceptable safety profile and led to a pathological response in a high proportion of patients. (Funded by Bristol Myers Squibb; NICHE-2 ClinicalTrials.gov number, NCT03026140.).
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- 2024
8. Outcomes of watch and wait after short-course radiotherapy in an international multicentre watch-and-wait cohort
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Geubels, Barbara M, van den Esschert, Aart-Jan, Temmink, Sofieke J D, Nilsson, Per J, Martling, Anna, Roodvoets, Annet G H, Peeters, Koen C M J, Sonneveld, Dirk J A, van Westreenen, Henderik L, Bujko, Krzysztof, Melenhorst, Jarno, Burger, Jacobus W A, Talsma, A Koen, Malcomson, Lee, Peters, Femke P, Beets, Geerard L, Grotenhuis, Brechtje A, Breukink, Stéphanie, International and Dutch Watch-and-Wait Consortium, Geubels, Barbara M, van den Esschert, Aart-Jan, Temmink, Sofieke J D, Nilsson, Per J, Martling, Anna, Roodvoets, Annet G H, Peeters, Koen C M J, Sonneveld, Dirk J A, van Westreenen, Henderik L, Bujko, Krzysztof, Melenhorst, Jarno, Burger, Jacobus W A, Talsma, A Koen, Malcomson, Lee, Peters, Femke P, Beets, Geerard L, Grotenhuis, Brechtje A, Breukink, Stéphanie, and International and Dutch Watch-and-Wait Consortium
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- 2024
9. Whole‐body MRI with diffusion‐weighted imaging as an adjunct to18F‐fluorodeoxyglucose positron emission tomography and CT in patients with suspected recurrent colorectal cancer
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Willemse, Jeroen R. J., primary, Lahaye, Max J., additional, Kok, Niels F. M., additional, Grotenhuis, Brechtje A., additional, Aalbers, Arend G. J., additional, Beets, Geerard L., additional, Rijsemus, Charlotte, additional, Maas, Monique, additional, van Golen, Larissa W., additional, Beets‐Tan, Regina G. H., additional, and Lambregts, Doenja M. J., additional
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- 2023
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10. Trends in epidemiology and primary treatment of anal squamous cell carcinoma in the Netherlands (1990–2021).
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Ho, Vincent K. Y., Deijen, Charlotte L., Hemmes, Birgit, van Erning, Felice N., Snaebjornsson, Petur, van Triest, Baukelien, and Grotenhuis, Brechtje A.
- Subjects
SQUAMOUS cell carcinoma ,POISSON regression ,EPIDEMIOLOGY ,AGE distribution ,DISEASE progression - Abstract
A rapid increase in the incidence of anal squamous cell carcinoma (SCC) was reported in several countries over the past decades. This study assessed trends in epidemiology and primary treatment over a 32‐year period (1990–2021) using the Netherlands Cancer Registry. The study population included 4273 patients, 44.2% male and 55.8% female (median age 63 years). The age‐standardised incidence rate (European Standardised Rate, ESR) increased from 0.5 to 1.6 per 100,000, which entailed an average annual percentage change (AAPC) of 5.0% (95% confidence interval [CI]: 4.5%–5.8%). While incidence among females increased continuously over the total period (AAPC 4.9%; 95%CI: 4.4%–5.6%), to 1.8 per 100,000 ESR in 2021, incidence among males increased until 2016 (annual percentage change [APC] of 6.3%; 95%CI: 5.6%–10.7%), after which it seemed to stabilise (APC −2.1%; 95%CI: −16.8%–4.5%). Significant trends were also observed in distribution of age, tumour stage and primary treatment modalities. Five‐year relative survival (RS) was estimated using the Pohar–Perme estimator, and this improved from 56.1% in 1990–1997 (95%CI: 49.3%–62.4%) to 67.9% in 2014–2021 (95%CI: 64.7%–70.9%), but remained poor for stage IV disease. Evaluation through a multivariable Poisson regression model demonstrated diagnosis in the most recent period to be independently associated with better RS, in addition to female sex, younger age, early disease stage and any treatment. In conclusion, the rising incidence of anal SCC seems to decline in males, but not in females, and advances in diagnostics and therapeutic management have likely contributed to improved prognosis. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Yield of Screening for COVID-19 in Asymptomatic Patients Before Elective or Emergency Surgery Using Chest CT and RT-PCR (SCOUT): Multicenter Study
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Puylaert, Carl A. J., Scheijmans, Jochem C. G., Borgstein, Alexander B. J., Andeweg, Caroline S., Bartels-Rutten, Annemarieke, Beets, Geerard L., van Berge Henegouwen, Mark I., Braak, Sicco J., Couvreur, Roy, Daams, Freek, van Es, Hendrik W., Franken, Lotte C., Grotenhuis, Brechtje A., Hendriks, Eduard R., de Hingh, Ignace H. J. T., Hoeijmakers, Fieke, ten Holder, Joris T., Huisman, Peter M., Kazemier, Geert, van Kesteren, Floortje, van Kesteren, Jurre, Keywani, Kammy, Kuiper, Sara Z., Lange, Maurits D. J., Lobatto, Mark E., du Mée, Arthur W. F., Poeze, Martijn, van Praag, Elise M., van Rossen, Jorit, van Santvoort, Hjalmar C., Sedee, Wouter J. A., Seelen, Leonard W. F., Sharabiany, Sarah, Sosef, Nico L., Quanjel, Marian J. R., Veltman, Jeroen, Verhagen, Tim, van de Vlasakker, Vincent C. J., Weeder, Pepijn D., van Werven, Jochem R., Wesdorp, Nina J., van Dieren, Susan, Han, Alvin X., Russell, Colin A., de Jong, Menno D., Bossuyt, Patrick M. M., Quarles van Ufford, Jet M. E., Prokop, Mathias W., Gisbertz, Suzanne S., Prins, Jan M., Besselink, Marc G., Boermeester, Marja A., Gietema, Hester A., and Stoker, Jaap
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- 2020
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12. Sense and non-sense of imaging in the era of organ preservation for rectal cancer
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Ou, Xinde, primary, van der Reijd, Denise J, additional, Lambregts, Doenja MJ, additional, Grotenhuis, Brechtje A, additional, van Triest, Baukelien, additional, Beets, Geerard L, additional, Beets-Tan, Regina GH, additional, and Maas, Monique, additional
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- 2023
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13. Size and depth of residual tumor after neoadjuvant chemoradiotherapy in rectal cancer – implications for the development of new imaging modalities for response assessment
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van der Stel, Stefan D., primary, van den Berg, Jose G., additional, Snaebjornsson, Petur, additional, Seignette, Iris M., additional, Witteveen, Mark, additional, Grotenhuis, Brechtje A., additional, Beets, Geerard L., additional, Post, Anouk L., additional, and Ruers, Theo J. M., additional
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- 2023
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14. Validated Pretreatment Prediction Models for Response to Neoadjuvant Therapy in Patients with Rectal Cancer: A Systematic Review and Critical Appraisal
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Tanaka, Max D., primary, Geubels, Barbara M., additional, Grotenhuis, Brechtje A., additional, Marijnen, Corrie A. M., additional, Peters, Femke P., additional, van der Mierden, Stevie, additional, Maas, Monique, additional, and Couwenberg, Alice M., additional
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- 2023
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15. Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort
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Nynke G, Greijdanu, Kiedo, Wienholt, Sander, Ubel, Kevin, Talboom, Gerjon, Hannink, Albert, Wolthui, Francisco B, de Lacy, Jérémie H, Lefevre, Michael, Solomon, Matteo, Frasson, Nicolas, Rotholtz, Quentin, Denost, Rodrigo O, Perez, Tsuyoshi, Konishi, Yves, Pani, Martin, Rutegård, Roel, Hompe, Camiel, Rosman, Frans, van Workum, Pieter J, Tani, Wilt, De, H W, Johanne, A Bremers, Andreas J, T Ferenschild, Flori, de Vriendt, Stefanie, D'Hoore, André, Bislenghi, Gabriele, Farguell, Jordi, M Lacy, Antonio, González Atienza, Paula, S van Kessel, Charlotte, Parc, Yann, Voron, Thibault, K Collard, Maxime, Sancho Muriel, Jorge, Cholewa, Hannia, A Mattioni, Laura, Frontali, Alice, W Polle, Sebastiaan, Polat, Fatih, J Obihara, Ndidi, B Vailati, Bruna, Kusters, Miranda, B Tuynmann, Jurriaan, A Hazen, Sanne J, J Grüter, Alexander A, Amano, Takahiro, Fujiwara, Hajime, Salomon, Mario, Ruiz, Hernán, Gonzalez, Ricardo, Estefanía, Diego, Avellaneda, Nicola, Carrie, Augusto, Santillan, Mateo, A Pantoja Pachajoa, Diana, Parodi, Matia, Gielis, Manuel, Binder, Alf-Dorian, Gürtler, Thoma, Riedl, Peter, Badiani, Sarit, Berney, Christophe, Morgan, Matthew, Hollington, Paul, da Silva, Nigel, Nair, Gavin, M Ho, Yiu, Lamparelli, Michael, Kapadia, Raj, M Kroon, Hidde, N Dudi-Venkata, Nagendra, Liu, Jianliang, Sammour, Tarik, Flamey, Nicola, Pattyn, Paul, Chaoui, Ahmed, Vansteenbrugge, Loui, J van den Broek, Nathalie E, Vanclooster, Patrick, de Gheldere, Charle, Pletinckx, Pieter, Defoort, Barbara, Dewulf, Maxime, Slavchev, Mihail, Belev, Nikolay, Atanasov, Boyko, Krastev, Panche, Sokolov, Manol, Maslyankov, Svilen, Gribnev, Petar, Pavlov, Vasil, Ivanov, Tsvetomir, Karamanliev, Martin, Filipov, Emil, Tonchev, Pencho, Aigner, Felix, Mitteregger, Martin, Allmer, Caterina, Seitinger, Gerald, Colucci, Nicola, Buchs, Nicola, Ris, Frédéric, Toso, Christian, Gialamas, Eleftherio, Vuagniaux, Aurélie, Chautems, Roland, Sauvain, Marc-Olivier, Daester, Silvio, von Flüe, Marku, Guenin, Marc-Olivier, Taha-Mehlitz, Stephanie, F Hess, Gabriel, Martínek, Lubomír, Skrovina, Matej, Machackova, Maria, Benčurik, Vladimir, Uluk, Deniz, Pratschke, Johann, S Dittrich, Luca, Guel-Klein, Safak, Perez, Daniel, Grass, Julia-Kristin, Melling, Nathaniel, Mueller, Simone, H Iversen, Lene, D Eriksen, Jacob, Baatrup, Gunnar, Al-Najami, Issam, Bjørsum-Meyer, Thoma, Teras, Jüri, M Teras, Roland, A Monib, Fatma, Eldin Abu Elnga Ahmed, Nagm, Alkady, Eithar, K Ali, Ahmed, Abd Elatti Khedr, Gehan, Samir Abdelaal, Ahmed, M Bassyouni Ashoush, Fouad, Ewedah, Moataz, M Elshennawy, Eslam, Hussein, Mohamed, Fernández-Martínez, Daniel, J García-Flórez, Lui, Fernández-Hevia, María, Suárez-Sánchez, Aida, Del Hoyo Aretxabala, Izaskun, Losada Docampo, Iria, Gómez Zabala, Jesú, Tejedor, Patricia, T Morales Bernaldo de Quirós, Javier, Bodega Quiroga, Ignacio, Navarro-Sánchez, Antonio, Soto Darias, Iván, López Fernández, Cristina, de La Cruz Cuadrado, Cristina, Sánchez-Guillén, Lui, López-Rodríguez-Arias, Francisco, Soler-Silva, Álvaro, Arroyo, Antonio, C Bernal-Sprekelsen, Juan, Á Gómez-Abril, Segundo, Gonzálvez, Paula, T Torres, María, Rubio Sánchez, Teresa, Blanco Antona, Francisco, E Sánchez Lara, Juan, A Alcázar Montero, José, Colás-Ruiz, Enrique, M Tasende-Presedo, Marta, Fernández-Hurtado, Ignacio, A Cifuentes-Ródenas, José, Castro Suárez, Marta, Losada, Manuel, Hernández, Miguel, Alonso, Alfredo, Diéguez, Beatriz, Serralta, Daniel, E Medina Quintana, Rita, M Gil Lopez, Jose, Lima Pinto, Francisca, Nieto-Moreno, Elena, Correa Bonito, Alba, Cerdán Santacruz, Carlo, Bermejo Marcos, Elena, García Septiem, Javier, Calero-Lillo, Aránzazu, Alanez-Saavedra, Javier, Muñoz-Collado, Salvador, López-Lara, Manuel, Labalde Martínez, María, Ferrero Herrero, Eduardo, Javier García Borda, Francisco, García Villar, Óscar, Escartín, Jorge, L Blas, Juan, Ferrer, Rocío, García Egea, Jorge, Rodríguez-Infante, Antonio, Mínguez-Ruiz, Germán, Carreño-Villarreal, Guillermo, Pire-Abaitua, Gerardo, Dziakova, Jana, Sáez-Cazallas Rodríguez, Carlo, J Pizarro Aranda, María, M Muguerza Huguet, José, Borda-Arrizabalaga, Nerea, M Enriquez-Navascués, José, Elorza Echaniz, Garazi, Saralegui Ansorena, Yolanda, Estaire-Gómez, Mercede, Martínez-Pinedo, Carlo, Barbero-Valenzuela, Alejandro, Ruíz-García, Pablo, Kraft, Miquel, J Gómez-Jurado, María, Pellino, Gianluca, Espín-Basany, Eloy, Cotte, Eddy, Panel, Nathalie, Goutard, Claire-Angéline, Deángelis, Nicola, Lauka, Lelde, Shaikh, Shafaque, Osborne, Laura, Ramsay, George, Nichita, Vladimir-Ion, Bhandari, Santosh, Sarmah, Panchali, M Bethune, Rob, M Pringle, Heather C, Massey, Lisa, E Fowler, George, S Hamid, Hytham K, D de Simone, Belinda, Kynaston, Jame, Bradley, Nichola, M Stienstra, Roxane, Gurjar, Shashank, Mukherjee, Tanmoy, Chandio, Ashfaq, Ahmed, Safia, Singh, Baljit, Runau, Francoi, Chaudhri, Sanjay, Siaw, Oliver, Sarveswaran, Janahan, Miu, Victor, Ashmore, Daniel, Darwich, Haitham, Singh-Ranger, Deepak, Singh, Nirbhaibir, Shaban, Mohamed, Gareb, Fahed, Petropolou, Thalia, Polydorou, Adrea, Dattani, Mit, Afzal, Asma, Bavikatte, Akshay, Sebastian, Boby, Ward, Nichola, Mishra, Amitabh, Manatakis, Dimitrio, Agalianos, Christo, Tasis, Nikolao, Antonopoulou, Maria-Ioanna, Karavokyros, Ioanni, Charalabopoulos, Alexandro, Schizas, Dimitrio, Baili, Efstratia, Syllaios, Athanasio, Karydakis, Lysandro, Vailas, Michail, Balalis, Dimitrio, Korkolis, Dimitrio, Plastiras, Ari, Rompou, Aliki, Xenaki, Sofia, Xynos, Evangelo, Chrysos, Emmanuel, Venianaki, Maria, Christodoulidis, Grigorio, Perivoliotis, Konstantino, Tzovaras, George, Baloyiannis, Ioanni, Ho, Man-Fung, Siu-Man Ng, Simon, Wing-Chung Mak, Tony, Futaba, Kaori, Šantak, Goran, Šimleša, Damir, Osić, Jurica, Zukanović, Goran, E Kelly, Michael, O Larkin, John, H McCormick, Paul, J Mehigan, Brian, M Connelly, Tara, Neary, Peter, Ryan, Jessica, Mccullough, Peter, A Al-Juaifari, Maytham, Hammoodi, Hayder, Hashim Abbood, Ali, Calabrò, Marcello, Muratore, Andrea, La Terra, Antonio, Farnesi, Francesca, V Feo, Carlo, Fabbri, Nicolò, Pesce, Antonio, Fazzin, Marta, Roscio, Francesco, Clerici, Federico, Lucchi, Andrea, Vittori, Laura, Agostinelli, Laura, Cristina Ripoli, Maria, Sambucci, Daniele, Porta, Andrea, Sinibaldi, Giovanni, Crescentini, Giacomo, Larcinese, Antonella, Picone, Emanuele, Persiani, Roberto, Biondi, Alberto, Pezzuto, Roberto, Lorenzon, Laura, Rizzo, Gianluca, Coco, Claudio, D'Agostino, Luca, Spinelli, Antonino, M Sacchi, Matteo, Carvello, Michele, Foppa, Caterina, Maroli, Annalisa, M Palini, Gian, Garulli, Gianluca, Zanini, Nicola, Delrio, Paolo, Rega, Daniela, Carbone, Fabio, Aversano, Alessia, Pirozzolo, Giovanni, Recordare, Alfonso, D'Alimonte, Lucrezia, Vignotto, Chiara, Corbellini, Carlo, M Sampietro, Gianluca, Lorusso, Leonardo, A Manzo, Carlo, Ghignone, Federico, Ugolini, Giampaolo, Montroni, Isacco, Pasini, Franceso, Pasini, Francesco, Ballabio, Michele, Bisagni, Pietro, T Armao, Francesca, Longhi, Marco, Ghazouani, Omar, Galleano, Raffaele, Tamini, Nicolò, Oldani, Massimo, Nespoli, Luca, Picciariello, Arcangelo, F Altomare, Donato, Tomasicchio, Giovanni, Lantone, Giuliano, Catena, Fausto, Giuffrida, Mario, Annicchiarico, Alfredo, Perrone, Gennaro, Grossi, Ugo, A Santoro, Giulio, Zanus, Giacomo, Iacomino, Alessandro, Novello, Simone, Passuello, Nicola, Zucchella, Martino, Puca, Lucia, Degiuli, Maurizio, Reddavid, Rossella, Scabini, Stefano, Aprile, Alessandra, Soriero, Domenico, Fioravanti, Emanuela, Rottoli, Matteo, Romano, Angela, Tanzanu, Marta, Belvedere, Angela, M Mariani, Nicolò, P Ceretti, Andrea, Opocher, Enrico, Gallo, Gaetano, Sammarco, Giuseppe, de Paola, Gilda, Pucciarelli, Salvatore, Marchegiani, Francesco, Spolverato, Gaya, Buzzi, Gianluca, Di Saverio, Salomone, Meroni, Paola, Parise, Cristiano, I Bottazzoli, Elisa, Lapolla, Pierfrancesco, Brachini, Gioia, Cirillo, Bruno, Mingoli, Andrea, Sica, Giuseppe, Siragusa, Leandro, Bellato, Vittoria, Cerbo, Daniele, A de Pasqual, Carlo, de Manzoni, Giovanni, A di Cosmo, Maria, H Alrayes, Bourhan M, M Qandeel, Mahmoud W, Bani Hani, Mohammad, Rabadi, Alexander, S El Muhtaseb, Mohammad, Abdeen, Basel, Karmi, Fahed, Žilinskas, Justa, Latkauskas, Tada, Tamelis, Algimanta, Pikūnienė, Ingrida, Šlenfuktas, Vyginta, Poskus, Toma, Kryzauskas, Mariu, Jakubauskas, Mata, Mikalauskas, Sauliu, Jakubauskiene, Lina, Y Hassan, Soha, Altrabulsi, Amani, Abdulwahed, Eman, Ghmagh, Reem, Deeknah, Abdulqudu, Alshareea, Entisar, Elhadi, Muhammed, Abujamra, Saleh, A Msherghi, Ahmed, E Tababa, Osama W, A Majbar, Mohammed, Souadka, Amine, Benkabbou, Amine, Mohsine, Raouf, Echiguer, Sabrillah, Moctezuma-Velázquez, Paulina, Salgado-Nesme, Noel, Vergara-Fernández, Omar, C Sainz-Hernández, Juan, E Alvarez-Bautista, Francisco, D Zakaria, Andee, Zakaria, Zaidi, K Wong, Michael P, Ismail, Razif, F Ibrahim, Aini, N Abdullah, Nik A, Julaihi, Rokayah, Bhat, Sameer, O'Grady, Greg, Bissett, Ian, Lamme, Ba, D Musters, Gijsbert, M Dinaux, Anne, A Grotenhuis, Brechtje, J Aalbers, Ernst J Steller Arend G, M Leeuwenburgh, Marjolein, T Rutten, Harm J, A Burger, Jacobus W, G Bloemen, Johanne, J Ketelaers, Stijn H, Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, K Talsma, Aaldert, Scheurink, Lieke, B van Praagh, Jasper, Segelman, Josefin, Nygren, Jona, Anderin, Kajsa, Tiefenthal, Marit, de Andrés, Beatriz, P Beltrán de Heredia, Juan, Vázquez, Andrea, Gómez, Tania, Golshani, Parisa, Kader, Rawaz, Mohamed, Abudi, Westerterp, Marinke, Marinelli, Andrea, Niemer, Quirine, G Doornebosch, Pascal, Shapiro, Joël, Vermaas, Maarten, R de Graaf, Eelco J, L van Westreenen, Hendrik, Zwakman, Marije, D van Dalsen, Annette, J Vles, Wouter, Nonner, Joost, R Toorenvliet, Boudewijn, J Janssen, Paul T, G Verdaasdonk, Emiel G, J Amelung, Femke, R Bahadoer, Koen C M J Peeters Renu, A Holman, Fabian, Heemskerk, Jeroen, Vosbeek, Noortje, A Leijtens, Jeroen W, M Taverne, Sophie B, M Heijnen, Bob H, El-Massoudi, Youssef, de Groot-van Veen, Irene, Hoff, Christiaan, Jou-Valencia, Daniela, J Consten, Esther C, A Burghgraef, Thij, Geitenbeek, Ritch, L Hulshof, Lorenzo G W, D Slooter, Gerrit, Reudink, Muriël, D Bouvy, Nicole, L Wildeboer, Aurelia C, Verstappen, Sonja, J Pennings, Alexander, van den Hengel, Berber, G Wijma, Allard, de Haan, Jael, F de Nes, Lindsey C, Heesink, Vera, Karsten, Tom, M Heidsma, Charlotte, J Koemans, Willem, T Dekker, Jan-Willem, J van der Zijden, Charlène, Roos, Daphne, Demirkiran, Ahmet, van der Burg, Sjirk, J Oosterling, Steven, J Hoogteijling, Tij, Wiering, Bastiaan, J Smeeing, Diederik P, Havenga, Klaa, Lutfi, Hamid, Tsimogiannis, Konstantino, Sköldberg, Filip, Folkesson, Joakim, den Boer, Frank, G van Schaik, Ted, van Gerven, Pieter, Sietses, Colin, C Hol, Jeroen, G Boerma, Evert-Jan, J Creemers, Davy M, K Schultz, Johanne, Frivold, Tone, Riis, Rolf, Gregussen, Hilde, Busund, Sondre, H Sjo, Ole, Gaard, Maria, Krohn, Nina, L Ersryd, Amanda, Leung, Edmund, Sultan, Hytham, Nabil Hajjaj, Baraa, Jehad Alhisi, Ahmed, E Khader, Ahmed A, Filipa Dias Mendes, Ana, Semião, Miguel, Queiroz Faria, Lui, Azevedo, Constança, M da Costa Devesa, Helena, Fortuna Martins, Sónia, M Rodrigues Jarimba, Aldo, M Ribeiro Marques, Sónia, Marques Ferreira, Rita, Oliveira, António, Ferreira, Cátia, Pereira, Ricardo, M Surlin, Valeriu, M Graure, Giorgiana, D Ramboiu, Stefan Patrascu Sandu, Negoi, Ionut, Ciubotaru, Cezar, Stoica, Bogdan, Tanase, Ioan, M Negoita, Valentina, Florea, Sabrina, Macau, Florin, Vasile, Mihai, Stefanescu, Victor, Dimofte, Gabriel-Mihail, Luncă, Sorinel, Roată, Cristian-Ene, Mușină, Ana-Maria, Garmanova, Tatiana, N Agapov, Mikhail, G Markaryan, Daniil, Eduard, Galliamov, Yanishev, Alexey, Abelevich, Alexander, Bazaev, Andrey, V Rodimov, Sergey, B Filimonov, Victor, A Melnikov, Andrey, A Suchkov, Igor, Drozdov, Evgeniy, N Kostromitskiy, Dmitriy, Sjöström, Olle, Matthiessen, Peter, Baban, Bayar, Gadan, Soran, Dehlaghi Jadid, Kaveh, Staffan, Maria, M Park, Jennifer, Rydbeck, Daniel, Lydrup, Marie-Louise, Buchwald, Pamela, Jutesten, Henrik, Darlin, Lotten, Lindqvist, Ebba, Nilsson, Karl, Larsson, Per-Ander, Jangmalm, Staffan, A Košir, Jurij, Tomažič, Aleš, Grosek, Jan, Košir Božič, Tajda, Zazo, Aya, Zazo, Rama, Fares, Hala, Ayoub, Kusay, Niazi, Ammar, Mansour, Ali, Abbas, Ayman, Tantoura, Mohammad, Hamdan, Alaa, Hassan, Naya, Hasan, Bassam, Saad, Ahmad, Sebai, Amine, Haddad, Ani, Maghrebi, Houcine, Kacem, Montasser, Yalkın, Ömer, Veysi Samsa, Mehmet, Atak, İbrahim, Balci, Bengi, Haberal, Elifcan, Dogan, Lütfi, E Gecim, Ibrahim, Akyol, Cihangir, A Koc, Mehmet, Sivrikoz, Emre, Piyadeoğlu, Deniz, O Avanagh, Dara, Sökmen, Selman, Bişgin, Tayfun, Günenç, Erşan, Güzel, Melek, Leventoğlu, Sezai, Yüksel, Osman, Kozan, Ramazan, Göbüt, Hüseyin, Cengiz, Fevzi, Erdinc, Kemal, Coşgun Acar, Nihan, Kamer, Erdinc, Özgür, İlker, Aydın, Oguzhan, Keskin, Metin, Türker Bulut, Mehmet, B Kulle, Cemil, Kara, Yasin, Sıbıç, Osman, H Özata, İbrahim, Buğra, Dursun, Balık, Emre, Çakır, Murat, Alhardan, Ana, Colak, Elif, B CiftciEngin Aybar, Ahmet, Can Sari, Ahmet, Demirli Atici, Semra, Kaya, Tayfun, Dursun, Ayberk, Calik, Bulent, Faruk Özkan, Ömer, Şeyda Ülgür, Hanife, Düzgün, Özgül, Monson, John, George, Sarah, Woods, Kayla, Al-Eryani, Fatima, Albakry, Rudaina, Coetzee, Emile, Boutall, Adam, Herman, Ayesiga, Warden, Claire, Mugla, Naser, Forgan, Tim, Mia, Imraan, Lambrechts, Anton, Roberto Persiani (ORCID:0000-0002-1537-5097), Alberto Biondi (ORCID:0000-0002-2470-7858), Nynke G, Greijdanu, Kiedo, Wienholt, Sander, Ubel, Kevin, Talboom, Gerjon, Hannink, Albert, Wolthui, Francisco B, de Lacy, Jérémie H, Lefevre, Michael, Solomon, Matteo, Frasson, Nicolas, Rotholtz, Quentin, Denost, Rodrigo O, Perez, Tsuyoshi, Konishi, Yves, Pani, Martin, Rutegård, Roel, Hompe, Camiel, Rosman, Frans, van Workum, Pieter J, Tani, Wilt, De, H W, Johanne, A Bremers, Andreas J, T Ferenschild, Flori, de Vriendt, Stefanie, D'Hoore, André, Bislenghi, Gabriele, Farguell, Jordi, M Lacy, Antonio, González Atienza, Paula, S van Kessel, Charlotte, Parc, Yann, Voron, Thibault, K Collard, Maxime, Sancho Muriel, Jorge, Cholewa, Hannia, A Mattioni, Laura, Frontali, Alice, W Polle, Sebastiaan, Polat, Fatih, J Obihara, Ndidi, B Vailati, Bruna, Kusters, Miranda, B Tuynmann, Jurriaan, A Hazen, Sanne J, J Grüter, Alexander A, Amano, Takahiro, Fujiwara, Hajime, Salomon, Mario, Ruiz, Hernán, Gonzalez, Ricardo, Estefanía, Diego, Avellaneda, Nicola, Carrie, Augusto, Santillan, Mateo, A Pantoja Pachajoa, Diana, Parodi, Matia, Gielis, Manuel, Binder, Alf-Dorian, Gürtler, Thoma, Riedl, Peter, Badiani, Sarit, Berney, Christophe, Morgan, Matthew, Hollington, Paul, da Silva, Nigel, Nair, Gavin, M Ho, Yiu, Lamparelli, Michael, Kapadia, Raj, M Kroon, Hidde, N Dudi-Venkata, Nagendra, Liu, Jianliang, Sammour, Tarik, Flamey, Nicola, Pattyn, Paul, Chaoui, Ahmed, Vansteenbrugge, Loui, J van den Broek, Nathalie E, Vanclooster, Patrick, de Gheldere, Charle, Pletinckx, Pieter, Defoort, Barbara, Dewulf, Maxime, Slavchev, Mihail, Belev, Nikolay, Atanasov, Boyko, Krastev, Panche, Sokolov, Manol, Maslyankov, Svilen, Gribnev, Petar, Pavlov, Vasil, Ivanov, Tsvetomir, Karamanliev, Martin, Filipov, Emil, Tonchev, Pencho, Aigner, Felix, Mitteregger, Martin, Allmer, Caterina, Seitinger, Gerald, Colucci, Nicola, Buchs, Nicola, Ris, Frédéric, Toso, Christian, Gialamas, Eleftherio, Vuagniaux, Aurélie, Chautems, Roland, Sauvain, Marc-Olivier, Daester, Silvio, von Flüe, Marku, Guenin, Marc-Olivier, Taha-Mehlitz, Stephanie, F Hess, Gabriel, Martínek, Lubomír, Skrovina, Matej, Machackova, Maria, Benčurik, Vladimir, Uluk, Deniz, Pratschke, Johann, S Dittrich, Luca, Guel-Klein, Safak, Perez, Daniel, Grass, Julia-Kristin, Melling, Nathaniel, Mueller, Simone, H Iversen, Lene, D Eriksen, Jacob, Baatrup, Gunnar, Al-Najami, Issam, Bjørsum-Meyer, Thoma, Teras, Jüri, M Teras, Roland, A Monib, Fatma, Eldin Abu Elnga Ahmed, Nagm, Alkady, Eithar, K Ali, Ahmed, Abd Elatti Khedr, Gehan, Samir Abdelaal, Ahmed, M Bassyouni Ashoush, Fouad, Ewedah, Moataz, M Elshennawy, 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Bermejo Marcos, Elena, García Septiem, Javier, Calero-Lillo, Aránzazu, Alanez-Saavedra, Javier, Muñoz-Collado, Salvador, López-Lara, Manuel, Labalde Martínez, María, Ferrero Herrero, Eduardo, Javier García Borda, Francisco, García Villar, Óscar, Escartín, Jorge, L Blas, Juan, Ferrer, Rocío, García Egea, Jorge, Rodríguez-Infante, Antonio, Mínguez-Ruiz, Germán, Carreño-Villarreal, Guillermo, Pire-Abaitua, Gerardo, Dziakova, Jana, Sáez-Cazallas Rodríguez, Carlo, J Pizarro Aranda, María, M Muguerza Huguet, José, Borda-Arrizabalaga, Nerea, M Enriquez-Navascués, José, Elorza Echaniz, Garazi, Saralegui Ansorena, Yolanda, Estaire-Gómez, Mercede, Martínez-Pinedo, Carlo, Barbero-Valenzuela, Alejandro, Ruíz-García, Pablo, Kraft, Miquel, J Gómez-Jurado, María, Pellino, Gianluca, Espín-Basany, Eloy, Cotte, Eddy, Panel, Nathalie, Goutard, Claire-Angéline, Deángelis, Nicola, Lauka, Lelde, Shaikh, Shafaque, Osborne, Laura, Ramsay, George, Nichita, Vladimir-Ion, Bhandari, Santosh, Sarmah, Panchali, M Bethune, Rob, M Pringle, Heather C, Massey, Lisa, E Fowler, George, S Hamid, Hytham K, D de Simone, Belinda, Kynaston, Jame, Bradley, Nichola, M Stienstra, Roxane, Gurjar, Shashank, Mukherjee, Tanmoy, Chandio, Ashfaq, Ahmed, Safia, Singh, Baljit, Runau, Francoi, Chaudhri, Sanjay, Siaw, Oliver, Sarveswaran, Janahan, Miu, Victor, Ashmore, Daniel, Darwich, Haitham, Singh-Ranger, Deepak, Singh, Nirbhaibir, Shaban, Mohamed, Gareb, Fahed, Petropolou, Thalia, Polydorou, Adrea, Dattani, Mit, Afzal, Asma, Bavikatte, Akshay, Sebastian, Boby, Ward, Nichola, Mishra, Amitabh, Manatakis, Dimitrio, Agalianos, Christo, Tasis, Nikolao, Antonopoulou, Maria-Ioanna, Karavokyros, Ioanni, Charalabopoulos, Alexandro, Schizas, Dimitrio, Baili, Efstratia, Syllaios, Athanasio, Karydakis, Lysandro, Vailas, Michail, Balalis, Dimitrio, Korkolis, Dimitrio, Plastiras, Ari, Rompou, Aliki, Xenaki, Sofia, Xynos, Evangelo, Chrysos, Emmanuel, Venianaki, Maria, Christodoulidis, Grigorio, Perivoliotis, Konstantino, Tzovaras, George, Baloyiannis, Ioanni, Ho, Man-Fung, Siu-Man Ng, Simon, Wing-Chung Mak, Tony, Futaba, Kaori, Šantak, Goran, Šimleša, Damir, Osić, Jurica, Zukanović, Goran, E Kelly, Michael, O Larkin, John, H McCormick, Paul, J Mehigan, Brian, M Connelly, Tara, Neary, Peter, Ryan, Jessica, Mccullough, Peter, A Al-Juaifari, Maytham, Hammoodi, Hayder, Hashim Abbood, Ali, Calabrò, Marcello, Muratore, Andrea, La Terra, Antonio, Farnesi, Francesca, V Feo, Carlo, Fabbri, Nicolò, Pesce, Antonio, Fazzin, Marta, Roscio, Francesco, Clerici, Federico, Lucchi, Andrea, Vittori, Laura, Agostinelli, Laura, Cristina Ripoli, Maria, Sambucci, Daniele, Porta, Andrea, Sinibaldi, Giovanni, Crescentini, Giacomo, Larcinese, Antonella, Picone, Emanuele, Persiani, Roberto, Biondi, Alberto, Pezzuto, Roberto, Lorenzon, Laura, Rizzo, Gianluca, Coco, Claudio, D'Agostino, Luca, Spinelli, Antonino, M Sacchi, Matteo, Carvello, Michele, Foppa, Caterina, Maroli, Annalisa, M Palini, Gian, Garulli, Gianluca, Zanini, Nicola, Delrio, Paolo, Rega, Daniela, Carbone, Fabio, Aversano, Alessia, Pirozzolo, Giovanni, Recordare, Alfonso, D'Alimonte, Lucrezia, Vignotto, Chiara, Corbellini, Carlo, M Sampietro, Gianluca, Lorusso, Leonardo, A Manzo, Carlo, Ghignone, Federico, Ugolini, Giampaolo, Montroni, Isacco, Pasini, Franceso, Pasini, Francesco, Ballabio, Michele, Bisagni, Pietro, T Armao, Francesca, Longhi, Marco, Ghazouani, Omar, Galleano, Raffaele, Tamini, Nicolò, Oldani, Massimo, Nespoli, Luca, Picciariello, Arcangelo, F Altomare, Donato, Tomasicchio, Giovanni, Lantone, Giuliano, Catena, Fausto, Giuffrida, Mario, Annicchiarico, Alfredo, Perrone, Gennaro, Grossi, Ugo, A Santoro, Giulio, Zanus, Giacomo, Iacomino, Alessandro, Novello, Simone, Passuello, Nicola, Zucchella, Martino, Puca, Lucia, Degiuli, Maurizio, Reddavid, Rossella, Scabini, Stefano, Aprile, Alessandra, Soriero, Domenico, Fioravanti, Emanuela, Rottoli, Matteo, Romano, Angela, Tanzanu, Marta, Belvedere, Angela, M Mariani, Nicolò, P Ceretti, Andrea, Opocher, Enrico, Gallo, Gaetano, Sammarco, Giuseppe, de Paola, Gilda, Pucciarelli, Salvatore, Marchegiani, Francesco, Spolverato, Gaya, Buzzi, Gianluca, Di Saverio, Salomone, Meroni, Paola, Parise, Cristiano, I Bottazzoli, Elisa, Lapolla, Pierfrancesco, Brachini, Gioia, Cirillo, Bruno, Mingoli, Andrea, Sica, Giuseppe, Siragusa, Leandro, Bellato, Vittoria, Cerbo, Daniele, A de Pasqual, Carlo, de Manzoni, Giovanni, A di Cosmo, Maria, H Alrayes, Bourhan M, M Qandeel, Mahmoud W, Bani Hani, Mohammad, Rabadi, Alexander, S El Muhtaseb, Mohammad, Abdeen, Basel, Karmi, Fahed, Žilinskas, Justa, Latkauskas, Tada, Tamelis, Algimanta, Pikūnienė, Ingrida, Šlenfuktas, Vyginta, Poskus, Toma, Kryzauskas, Mariu, Jakubauskas, Mata, Mikalauskas, Sauliu, Jakubauskiene, Lina, Y Hassan, Soha, Altrabulsi, Amani, Abdulwahed, Eman, Ghmagh, Reem, Deeknah, Abdulqudu, Alshareea, Entisar, Elhadi, Muhammed, Abujamra, Saleh, A Msherghi, Ahmed, E Tababa, Osama W, A Majbar, Mohammed, Souadka, Amine, Benkabbou, Amine, Mohsine, Raouf, Echiguer, Sabrillah, Moctezuma-Velázquez, Paulina, Salgado-Nesme, Noel, Vergara-Fernández, Omar, C Sainz-Hernández, Juan, E Alvarez-Bautista, Francisco, D Zakaria, Andee, Zakaria, Zaidi, K Wong, Michael P, Ismail, Razif, F Ibrahim, Aini, N Abdullah, Nik A, Julaihi, Rokayah, Bhat, Sameer, O'Grady, Greg, Bissett, Ian, Lamme, Ba, D Musters, Gijsbert, M Dinaux, Anne, A Grotenhuis, Brechtje, J Aalbers, Ernst J Steller Arend G, M Leeuwenburgh, Marjolein, T Rutten, Harm J, A Burger, Jacobus W, G Bloemen, Johanne, J Ketelaers, Stijn H, Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, K Talsma, Aaldert, Scheurink, Lieke, B van Praagh, Jasper, Segelman, Josefin, Nygren, Jona, Anderin, Kajsa, Tiefenthal, Marit, de Andrés, Beatriz, P Beltrán de Heredia, Juan, Vázquez, Andrea, Gómez, Tania, Golshani, Parisa, Kader, Rawaz, Mohamed, Abudi, Westerterp, Marinke, Marinelli, Andrea, Niemer, Quirine, G Doornebosch, Pascal, Shapiro, Joël, Vermaas, Maarten, R de Graaf, Eelco J, L van Westreenen, Hendrik, Zwakman, Marije, D van Dalsen, Annette, J Vles, Wouter, Nonner, Joost, R Toorenvliet, Boudewijn, J Janssen, Paul T, G Verdaasdonk, Emiel G, J Amelung, Femke, R Bahadoer, Koen C M J Peeters Renu, A Holman, Fabian, Heemskerk, Jeroen, Vosbeek, Noortje, A Leijtens, Jeroen W, M Taverne, Sophie B, M Heijnen, Bob H, El-Massoudi, Youssef, de Groot-van Veen, Irene, Hoff, Christiaan, Jou-Valencia, Daniela, J Consten, Esther C, A Burghgraef, Thij, Geitenbeek, Ritch, L Hulshof, Lorenzo G W, D Slooter, Gerrit, Reudink, Muriël, D Bouvy, Nicole, L Wildeboer, Aurelia C, Verstappen, Sonja, J Pennings, Alexander, van den Hengel, Berber, G Wijma, Allard, de Haan, Jael, F de Nes, Lindsey C, Heesink, Vera, Karsten, Tom, M Heidsma, Charlotte, J Koemans, Willem, T Dekker, Jan-Willem, J van der Zijden, Charlène, Roos, Daphne, Demirkiran, Ahmet, van der Burg, Sjirk, J Oosterling, Steven, J Hoogteijling, Tij, Wiering, Bastiaan, J Smeeing, Diederik P, Havenga, Klaa, Lutfi, Hamid, Tsimogiannis, Konstantino, Sköldberg, Filip, Folkesson, Joakim, den Boer, Frank, G van Schaik, Ted, van Gerven, Pieter, Sietses, Colin, C Hol, Jeroen, G Boerma, Evert-Jan, J Creemers, Davy M, K Schultz, Johanne, Frivold, Tone, Riis, Rolf, Gregussen, Hilde, Busund, Sondre, H Sjo, Ole, Gaard, Maria, Krohn, Nina, L Ersryd, Amanda, Leung, Edmund, Sultan, Hytham, Nabil Hajjaj, Baraa, Jehad Alhisi, Ahmed, E Khader, Ahmed A, Filipa Dias Mendes, Ana, Semião, Miguel, Queiroz Faria, Lui, Azevedo, Constança, M da Costa Devesa, Helena, Fortuna Martins, Sónia, M Rodrigues Jarimba, Aldo, M Ribeiro Marques, Sónia, Marques Ferreira, Rita, Oliveira, António, Ferreira, Cátia, Pereira, Ricardo, M Surlin, Valeriu, M Graure, Giorgiana, D Ramboiu, Stefan Patrascu Sandu, Negoi, Ionut, Ciubotaru, Cezar, Stoica, Bogdan, Tanase, Ioan, M Negoita, Valentina, Florea, Sabrina, Macau, Florin, Vasile, Mihai, Stefanescu, Victor, Dimofte, Gabriel-Mihail, Luncă, Sorinel, Roată, Cristian-Ene, Mușină, Ana-Maria, Garmanova, Tatiana, N Agapov, Mikhail, G Markaryan, Daniil, Eduard, Galliamov, Yanishev, Alexey, Abelevich, Alexander, Bazaev, Andrey, V Rodimov, Sergey, B Filimonov, Victor, A Melnikov, Andrey, A Suchkov, Igor, Drozdov, Evgeniy, N Kostromitskiy, Dmitriy, Sjöström, Olle, Matthiessen, Peter, Baban, Bayar, Gadan, Soran, Dehlaghi Jadid, Kaveh, Staffan, Maria, M Park, Jennifer, Rydbeck, Daniel, Lydrup, Marie-Louise, Buchwald, Pamela, Jutesten, Henrik, Darlin, Lotten, Lindqvist, Ebba, Nilsson, Karl, Larsson, Per-Ander, Jangmalm, Staffan, A Košir, Jurij, Tomažič, Aleš, Grosek, Jan, Košir Božič, Tajda, Zazo, Aya, Zazo, Rama, Fares, Hala, Ayoub, Kusay, Niazi, Ammar, Mansour, Ali, Abbas, Ayman, Tantoura, Mohammad, Hamdan, Alaa, Hassan, Naya, Hasan, Bassam, Saad, Ahmad, Sebai, Amine, Haddad, Ani, Maghrebi, Houcine, Kacem, Montasser, Yalkın, Ömer, Veysi Samsa, Mehmet, Atak, İbrahim, Balci, Bengi, Haberal, Elifcan, Dogan, Lütfi, E Gecim, Ibrahim, Akyol, Cihangir, A Koc, Mehmet, Sivrikoz, Emre, Piyadeoğlu, Deniz, O Avanagh, Dara, Sökmen, Selman, Bişgin, Tayfun, Günenç, Erşan, Güzel, Melek, Leventoğlu, Sezai, Yüksel, Osman, Kozan, Ramazan, Göbüt, Hüseyin, Cengiz, Fevzi, Erdinc, Kemal, Coşgun Acar, Nihan, Kamer, Erdinc, Özgür, İlker, Aydın, Oguzhan, Keskin, Metin, Türker Bulut, Mehmet, B Kulle, Cemil, Kara, Yasin, Sıbıç, Osman, H Özata, İbrahim, Buğra, Dursun, Balık, Emre, Çakır, Murat, Alhardan, Ana, Colak, Elif, B CiftciEngin Aybar, Ahmet, Can Sari, Ahmet, Demirli Atici, Semra, Kaya, Tayfun, Dursun, Ayberk, Calik, Bulent, Faruk Özkan, Ömer, Şeyda Ülgür, Hanife, Düzgün, Özgül, Monson, John, George, Sarah, Woods, Kayla, Al-Eryani, Fatima, Albakry, Rudaina, Coetzee, Emile, Boutall, Adam, Herman, Ayesiga, Warden, Claire, Mugla, Naser, Forgan, Tim, Mia, Imraan, Lambrechts, Anton, Roberto Persiani (ORCID:0000-0002-1537-5097), and Alberto Biondi (ORCID:0000-0002-2470-7858)
- Abstract
Objective:To develop and validate a prediction model (STOMA score) for 1-year stoma-free survival in patients with rectal cancer (RC) with anastomotic leakage (AL).Background:AL after RC resection often results in a permanent stoma.Methods:This international retrospective cohort study (TENTACLE-Rectum) encompassed 216 participating centres and included patients who developed AL after RC surgery between 2014 and 2018. Clinically relevant predictors for 1-year stoma-free survival were included in uni and multivariable logistic regression models. The STOMA score was developed and internally validated in a cohort of patients operated between 2014 and 2017, with subsequent temporal validation in a 2018 cohort. The discriminative power and calibration of the models' performance were evaluated.Results:This study included 2499 patients with AL, 1954 in the development cohort and 545 in the validation cohort. Baseline characteristics were comparable. One-year stoma-free survival was 45.0% in the development cohort and 43.7% in the validation cohort. The following predictors were included in the STOMA score: sex, age, American Society of Anestesiologist classification, body mass index, clinical M-disease, neoadjuvant therapy, abdominal and transanal approach, primary defunctioning stoma, multivisceral resection, clinical setting in which AL was diagnosed, postoperative day of AL diagnosis, abdominal contamination, anastomotic defect circumference, bowel wall ischemia, anastomotic fistula, retraction, and reactivation leakage. The STOMA score showed good discrimination and calibration (c-index: 0.71, 95% CI: 0.66-0.76).Conclusions:The STOMA score consists of 18 clinically relevant factors and estimates the individual risk for 1-year stoma-free survival in patients with AL after RC surgery, which may improve patient counseling and give guidance when analyzing the efficacy of different treatment strategies in future studies.
- Published
- 2023
16. Stoma-free survival after anastomotic leak following rectal cancer resection: worldwide cohort of 2470 patients
- Author
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Nynke G, Greijdanu, Kiedo, Wienholt, Sander, Ubel, Kevin, Talboom, Gerjon, Hannink, Albert, Wolthui, F Borja, de Lacy, Jérémie H, Lefevre, Michael, Solomon, Matteo, Frasson, Nicolas, Rotholtz, Quentin, Denost, Rodrigo O, Perez, Tsuyoshi, Konishi, Yves, Pani, Martin, Rutegård, Roel, Hompe, Camiel, Rosman, Frans, van Workum, Pieter J, Tani, Johannes H W, de Wilt, A Bremers, Andreas J, T Ferenschild, Flori, de Vriendt, Stefanie, D'Hoore, André, Bislenghi, Gabriele, Farguell, Jordi, M Lacy, Antonio, González Atienza, Paula, S van Kessel, Charlotte, Parc, Yann, Voron, Thibault, K Collard, Maxime, Sancho Muriel, Jorge, Cholewa, Hannia, A Mattioni, Laura, Frontali, Alice, W Polle, Sebastiaan, Polat, Fatih, J Obihara, Ndidi, B Vailati, Bruna, Kusters, Miranda, B Tuynmann, Jurriaan, A Hazen, Sanne J, J Grüter, Alexander A, Amano, Takahiro, Fujiwara, Hajime, Salomon, Mario, Ruiz, Hernán, Gonzalez, Ricardo, Estefanía, Diego, Avellaneda, Nicola, Carrie, Augusto, Santillan, Mateo, A Pantoja 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Daniel, Darwich, Haitham, Singh-Ranger, Deepak, Singh, Nirbhaibir, Shaban, Mohamed, Gareb, Fahed, Petropolou, Thalia, Polydorou, Adrea, Dattani, Mit, Afzal, Asma, Bavikatte, Akshay, Sebastian, Boby, Ward, Nichola, Mishra, Amitabh, Manatakis, Dimitrio, Agalianos Nikolaos Tasis, Christo, Antonopoulou, Maria-Ioanna, Karavokyros, Ioanni, Charalabopoulos, Alexandro, Schizas, Dimitrio, Baili, Efstratia, Syllaios, Athanasio, Karydakis, Lysandro, Vailas, Michail, Balalis, Dimitrio, Korkolis, Dimitrio, Plastiras, Ari, Rompou, Aliki, Xenaki, Sofia, Xynos, Evangelo, Chrysos, Emmanuel, Venianaki, Maria, Christodoulidis, Grigorio, Perivoliotis, Konstantino, Tzovaras, George, Baloyiannis, Ioanni, Ho, Man-Fung, Siu-Man Ng, Simon, Wing-Chung Mak, Tony, Futaba, Kaori, Šantak, Goran, Šimleša, Damir, Ćosić, Jurica, Zukanović, Goran, E Kelly, Michael, O Larkin, John, H McCormick, Paul, J Mehigan, Brian, M Connelly, Tara, Neary, Peter, Ryan, Jessica, Mccullough, Peter, A Al-Juaifari, Maytham, Hammoodi, Hayder, Hashim Abbood, Ali, Calabrò, Marcello, Muratore, Andrea, La Terra, Antonio, Farnesi, Francesca, V Feo, Carlo, Fabbri, Nicolò, Pesce, Antonio, Fazzin, Marta, Roscio, Francesco, Clerici, Federico, Lucchi, Andrea, Vittori, Laura, Agostinelli, Laura, Cristina Ripoli, Maria, Sambucci, Daniele, Porta, Andrea, Sinibaldi, Giovanni, Crescentini, Giacomo, Larcinese, Antonella, Picone, Emanuele, Persiani, Roberto, Biondi, Alberto, Pezzuto, Roberto, Lorenzon, Laura, Rizzo, Gianluca, Coco, Claudio, D'Agostino, Luca, Spinelli, Antonino, M Sacchi, Matteo, Carvello, Michele, Foppa, Caterina, Maroli, Annalisa, M Palini, Gian, Garulli, Gianluca, Zanini, Nicola, Delrio, Paolo, Rega, Daniela, Carbone, Fabio, Aversano, Alessia, Pirozzolo, Giovanni, Recordare, Alfonso, D'Alimonte, Lucrezia, Vignotto, Chiara, Corbellini, Carlo, M Sampietro, Gianluca, Lorusso, Leonardo, A Manzo, Carlo, Ghignone, Federico, Ugolini, Giampaolo, Montroni, Isacco, Pasini, Franceso, Pasini, Francesco, Ballabio, Michele, Bisagni, Pietro, T Armao, Francesca, Longhi, Marco, Ghazouani, Omar, Galleano, Raffaele, Tamini, Nicolò, Oldani, Massimo, Nespoli, Luca, Picciariello, Arcangelo, F Altomare, Donato, Tomasicchio, Giovanni, Lantone, Giuliano, Catena, Fausto, Giuffrida, Mario, Annicchiarico, Alfredo, Perrone, Gennaro, Grossi, Ugo, A Santoro, Giulio, Zanus Alessandro Iacomino, Giacomo, Novello, Simone, Passuello, Nicola, Zucchella, Martino, Puca, Lucia, Degiuli, Maurizio, Reddavid, Rossella, Scabini, Stefano, Aprile, Alessandra, Soriero, Domenico, Fioravanti, Emanuela, Rottoli, Matteo, Romano, Angela, Tanzanu, Marta, Belvedere, Angela, M Mariani, Nicolò, P Ceretti, Andrea, Opocher, Enrico, Gallo, Gaetano, Sammarco, Giuseppe, de Paola, Gilda, Pucciarelli, Salvatore, Marchegiani, Francesco, Spolverato, Gaya, Buzzi, Gianluca, Di Saverio, Salomone, Meroni, Paola, Parise, Cristiano, I Bottazzoli, Elisa, Lapolla, Pierfrancesco, Brachini, Gioia, Cirillo, Bruno, Mingoli, Andrea, Sica, Giuseppe, Siragusa, Leandro, Bellato, Vittoria, Cerbo, Daniele, A de Pasqual, Carlo, de Manzoni, Giovanni, A di Cosmo, Maria, H Alrayes, Bourhan M, M Qandeel, Mahmoud W, Bani Hani, Mohammad, Rabadi, Alexander, S El Muhtaseb, Mohammad, Abdeen, Basel, Karmi, Fahed, Žilinskas, Justa, Latkauskas, Tada, Tamelis, Algimanta, Pikūnienė, Ingrida, Šlenfuktas, Vyginta, Poskus, Toma, Kryzauskas, Mariu, Jakubauskas, Mata, Mikalauskas, Sauliu, Jakubauskiene, Lina, Y Hassan, Soha, Altrabulsi, Amani, Abdulwahed, Eman, Ghmagh, Reem, Deeknah, Abdulqudu, Alshareea, Entisar, Elhadi, Muhammed, Abujamra, Saleh, A Msherghi, Ahmed, E Tababa, Osama W, A Majbar, Mohammed, Souadka, Amine, Benkabbou, Amine, Mohsine, Raouf, Echiguer, Sabrillah, Moctezuma-Velázquez, Paulina, Salgado-Nesme, Noel, Vergara-Fernández, Omar, C Sainz-Hernández, Juan, E Alvarez-Bautista, Francisco, D Zakaria, Andee, Zakaria, Zaidi, K Wong, Michael P, Ismail, Razif, F Ibrahim, Aini, N Abdullah, Nik A, Julaihi, Rokayah, Bhat, Sameer, O'Grady, Greg, Bissett, Ian, Lamme, Ba, D Musters, Gijsbert, M Dinaux, Anne, A Grotenhuis, Brechtje, J Aalbers, Ernst J Steller Arend G, M Leeuwenburgh, Marjolein, T Rutten, Harm J, A Burger, Jacobus W, G Bloemen, Johanne, J Ketelaers, Stijn H, Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, K Talsma, Aaldert, Scheurink, Lieke, B van Praagh, Jasper, Segelman, Josefin, Nygren, Jona, Anderin, Kajsa, Tiefenthal, Marit, de Andrés, Beatriz, P Beltrán de Heredia, Juan, Vázquez, Andrea, Gómez, Tania, Golshani, Parisa, Kader, Rawaz, Mohamed, Abudi, Westerterp, Marinke, Marinelli, Andrea, Niemer, Quirine, G Doornebosch, Pascal, Shapiro, Joël, Vermaas, Maarten, R de Graaf, Eelco J, L van Westreenen, Hendrik, Zwakman, Marije, D van Dalsen, Annette, J Vles, Wouter, Nonner, Joost, R Toorenvliet, Boudewijn, J Janssen, Paul T, G Verdaasdonk, Emiel G, J Amelung, Femke, R Bahadoer, Koen C M J Peeters Renu, A Holman, Fabian, Heemskerk, Jeroen, Vosbeek, Noortje, A Leijtens, Jeroen W, M Taverne, Sophie B, M Heijnen, Bob H, El-Massoudi, Youssef, de Groot-van Veen, Irene, Hoff, Christiaan, Jou-Valencia, Daniela, A Burghgraef, Esther C J Consten Thij, Geitenbeek, Ritch, L Hulshof, Lorenzo G W, D Slooter, Gerrit, Reudink, Muriël, D Bouvy, Nicole, L Wildeboer, Aurelia C, Verstappen, Sonja, J Pennings, Alexander, van den Hengel, Berber, G Wijma, Allard, de Haan, Jael, F de Nes, Lindsey C, Heesink, Vera, Karsten, Tom, M Heidsma, Charlotte, J Koemans, Willem, T Dekker, Jan-Willem, J van der Zijden, Charlène, Roos, Daphne, Demirkiran, Ahmet, van der Burg, Sjirk, J Oosterling, Steven, J Hoogteijling, Tij, Wiering, Bastiaan, J Smeeing, Diederik P, Havenga, Klaa, Lutfi, Hamid, J Consten, Esther C, Tsimogiannis, Konstantino, Sköldberg, Filip, Folkesson, Joakim, den Boer, Frank, G van Schaik, Ted, van Gerven, Pieter, Sietses, Colin, C Hol, Jeroen, G Boerma, Evert-Jan, J Creemers, Davy M, K Schultz, Johanne, Frivold, Tone, Riis, Rolf, Gregussen, Hilde, Busund, Sondre, H Sjo, Ole, Gaard, Maria, Krohn, Nina, L Ersryd, Amanda, Leung, Edmund, Sultan, Hytham, Nabil Hajjaj, Baraa, Jehad Alhisi, Ahmed, E Khader, Ahmed A, Filipa Dias Mendes, Ana, Semião, Miguel, Queiroz Faria, Lui, Azevedo, Constança, M da Costa Devesa, Helena, Fortuna Martins, Sónia, M Rodrigues Jarimba, Aldo, M Ribeiro Marques, Sónia, Marques Ferreira, Rita, Oliveira, António, Ferreira, Cátia, Pereira, Ricardo, M Surlin, Valeriu, M Graure, Giorgiana, D Ramboiu, Stefan Patrascu Sandu, Negoi, Ionut, Ciubotaru, Cezar, Stoica, Bogdan, Tanase, Ioan, M Negoita, Valentina, Florea, Sabrina, Macau, Florin, Vasile, Mihai, Stefanescu, Victor, Dimofte, Gabriel-Mihail, Luncă, Sorinel, Roată, Cristian-Ene, Mușină, Ana-Maria, Garmanova, Tatiana, N Agapov, Mikhail, G Markaryan, Daniil, Eduard, Galliamov, Yanishev, Alexey, Abelevich, Alexander, Bazaev, Andrey, V Rodimov, Sergey, B Filimonov, Victor, A Melnikov, Andrey, A Suchkov, Igor, S Drozdov, Evgeniy, N Kostromitskiy, Dmitriy, Sjöström, Olle, Matthiessen, Peter, Baban, Bayar, Gadan, Soran, Dehlaghi 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Osman, H Özata, İbrahim, Buğra, Dursun, Balık, Emre, Çakır, Murat, Alhardan, Ana, Colak, Elif, B CiftciEngin Aybar, Ahmet, Can Sari, Ahmet, Demirli Atici, Semra, Kaya, Tayfun, Dursun, Ayberk, Calik, Bulent, Faruk Özkan, Ömer, Şeyda Ülgür, Hanife, Düzgün, Özgül, Monson, John, George, Sarah, Woods, Kayla, Al-Eryani, Fatima, Albakry, Rudaina, Coetzee, Emile, Boutall, Adam, Herman, Ayesiga, Warden, Claire, Mugla, Naser, Forgan, Tim, Mia, Imraan, Lambrechts, Anton, Roberto Persiani (ORCID:0000-0002-1537-5097), Alberto Biondi (ORCID:0000-0002-2470-7858), Roberto Pezzuto, Laura Lorenzon (ORCID:0000-0001-6736-0383), Gianluca Rizzo, Claudio Coco (ORCID:0000-0002-4713-7093), Nynke G, Greijdanu, Kiedo, Wienholt, Sander, Ubel, Kevin, Talboom, Gerjon, Hannink, Albert, Wolthui, F Borja, de Lacy, Jérémie H, Lefevre, Michael, Solomon, Matteo, Frasson, Nicolas, Rotholtz, Quentin, Denost, Rodrigo O, Perez, Tsuyoshi, Konishi, Yves, Pani, Martin, Rutegård, Roel, Hompe, Camiel, Rosman, Frans, van Workum, Pieter J, Tani, Johannes H W, de Wilt, A Bremers, Andreas J, T Ferenschild, Flori, de Vriendt, Stefanie, D'Hoore, André, Bislenghi, Gabriele, Farguell, Jordi, M Lacy, Antonio, González Atienza, Paula, S van Kessel, Charlotte, Parc, Yann, Voron, Thibault, K Collard, Maxime, Sancho Muriel, Jorge, Cholewa, Hannia, A Mattioni, Laura, Frontali, Alice, W Polle, Sebastiaan, Polat, Fatih, J Obihara, Ndidi, B Vailati, Bruna, Kusters, Miranda, B Tuynmann, Jurriaan, A Hazen, Sanne J, J Grüter, Alexander A, Amano, Takahiro, Fujiwara, Hajime, Salomon, Mario, Ruiz, Hernán, Gonzalez, Ricardo, Estefanía, Diego, Avellaneda, Nicola, Carrie, Augusto, Santillan, Mateo, A Pantoja Pachajoa, Diana, Parodi, Matia, Gielis, Manuel, Binder, Alf-Dorian, Gürtler, Thoma, Riedl, Peter, Badiani, Sarit, Berney, Christophe, Morgan, Matthew, Hollington, Paul, da Silva, Nigel, Nair, Gavin, M Ho, Yiu, Lamparelli, Michael, Kapadia, Raj, M Kroon, Hidde, N Dudi-Venkata, Nagendra, Liu, Jianliang, Sammour, Tarik, Flamey, 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Bjørsum-Meyer, Thoma, Teras, Jüri, M Teras, Roland, A Monib, Fatma, Eldin Abu Elnga Ahmed, Nagm, Alkady, Eithar, K Ali, Ahmed, Abd Elatti Khedr, Gehan, Samir Abdelaal, Ahmed, M Bassyouni Ashoush, Fouad, Ewedah, Moataz, M Elshennawy, Eslam, Hussein, Mohamed, Fernández-Martínez, Daniel, J García-Flórez, Lui, Fernández-Hevia, María, Suárez-Sánchez, Aida, Del Hoyo Aretxabala, Izaskun, Losada Docampo, Iria, Gómez Zabala, Jesú, Tejedor, Patricia, T Morales Bernaldo de Quirós, Javier, Bodega Quiroga, Ignacio, Navarro-Sánchez, Antonio, Soto Darias, Iván, López Fernández, Cristina, de La Cruz Cuadrado, Cristina, Sánchez-Guillén, Lui, López-Rodríguez-Arias, Francisco, Soler-Silva, Álvaro, Arroyo, Antonio, C Bernal-Sprekelsen, Juan, Á Gómez-Abril, Segundo, Gonzálvez, Paula, T Torres, María, Rubio Sánchez, Teresa, Blanco Antona, Francisco, E Sánchez Lara, Juan, A Alcázar Montero, José, Mendoza-Moreno, Fernando, Díez-Alonso, Manuel, Matías-García, Belén, Quiroga-Valcárcel, Ana, Colás-Ruiz, Enrique, M Tasende-Presedo, Marta, Fernández-Hurtado, Ignacio, A Cifuentes-Ródenas, José, Castro Suárez, Marta, Losada, Manuel, Hernández, Miguel, Alonso, Alfredo, Diéguez, Beatriz, Serralta, Daniel, E Medina Quintana, Rita, M Gil Lopez, Jose, Lima Pinto, Francisca, Nieto-Moreno, Elena, Correa Bonito, Alba, Cerdán Santacruz, Carlo, Bermejo Marcos, Elena, García Septiem, Javier, Calero-Lillo, Aránzazu, Alanez-Saavedra, Javier, Muñoz-Collado, Salvador, López-Lara, Manuel, Labalde Martínez, María, Ferrero Herrero, Eduardo, Javier García Borda, Francisco, García Villar, Óscar, Escartín, Jorge, L Blas, Juan, Ferrer, Rocío, García Egea, Jorge, Rodríguez-Infante, Antonio, Mínguez-Ruiz, Germán, Carreño-Villarreal, Guillermo, Pire-Abaitua, Gerardo, Dziakova, Jana, Sáez-Cazallas Rodríguez, Carlo, J Pizarro Aranda, María, M Muguerza Huguet, José, Borda-Arrizabalaga, Nerea, M Enriquez-Navascués, José, Elorza Echaniz, Garazi, Saralegui Ansorena, Yolanda, Estaire-Gómez, Mercede, Martínez-Pinedo, Carlo, 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Ioanni, Charalabopoulos, Alexandro, Schizas, Dimitrio, Baili, Efstratia, Syllaios, Athanasio, Karydakis, Lysandro, Vailas, Michail, Balalis, Dimitrio, Korkolis, Dimitrio, Plastiras, Ari, Rompou, Aliki, Xenaki, Sofia, Xynos, Evangelo, Chrysos, Emmanuel, Venianaki, Maria, Christodoulidis, Grigorio, Perivoliotis, Konstantino, Tzovaras, George, Baloyiannis, Ioanni, Ho, Man-Fung, Siu-Man Ng, Simon, Wing-Chung Mak, Tony, Futaba, Kaori, Šantak, Goran, Šimleša, Damir, Ćosić, Jurica, Zukanović, Goran, E Kelly, Michael, O Larkin, John, H McCormick, Paul, J Mehigan, Brian, M Connelly, Tara, Neary, Peter, Ryan, Jessica, Mccullough, Peter, A Al-Juaifari, Maytham, Hammoodi, Hayder, Hashim Abbood, Ali, Calabrò, Marcello, Muratore, Andrea, La Terra, Antonio, Farnesi, Francesca, V Feo, Carlo, Fabbri, Nicolò, Pesce, Antonio, Fazzin, Marta, Roscio, Francesco, Clerici, Federico, Lucchi, Andrea, Vittori, Laura, Agostinelli, Laura, Cristina Ripoli, Maria, Sambucci, Daniele, Porta, Andrea, Sinibaldi, 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Giulio, Zanus Alessandro Iacomino, Giacomo, Novello, Simone, Passuello, Nicola, Zucchella, Martino, Puca, Lucia, Degiuli, Maurizio, Reddavid, Rossella, Scabini, Stefano, Aprile, Alessandra, Soriero, Domenico, Fioravanti, Emanuela, Rottoli, Matteo, Romano, Angela, Tanzanu, Marta, Belvedere, Angela, M Mariani, Nicolò, P Ceretti, Andrea, Opocher, Enrico, Gallo, Gaetano, Sammarco, Giuseppe, de Paola, Gilda, Pucciarelli, Salvatore, Marchegiani, Francesco, Spolverato, Gaya, Buzzi, Gianluca, Di Saverio, Salomone, Meroni, Paola, Parise, Cristiano, I Bottazzoli, Elisa, Lapolla, Pierfrancesco, Brachini, Gioia, Cirillo, Bruno, Mingoli, Andrea, Sica, Giuseppe, Siragusa, Leandro, Bellato, Vittoria, Cerbo, Daniele, A de Pasqual, Carlo, de Manzoni, Giovanni, A di Cosmo, Maria, H Alrayes, Bourhan M, M Qandeel, Mahmoud W, Bani Hani, Mohammad, Rabadi, Alexander, S El Muhtaseb, Mohammad, Abdeen, Basel, Karmi, Fahed, Žilinskas, Justa, Latkauskas, Tada, Tamelis, Algimanta, Pikūnienė, Ingrida, Šlenfuktas, Vyginta, Poskus, Toma, Kryzauskas, Mariu, Jakubauskas, Mata, Mikalauskas, Sauliu, Jakubauskiene, Lina, Y Hassan, Soha, Altrabulsi, Amani, Abdulwahed, Eman, Ghmagh, Reem, Deeknah, Abdulqudu, Alshareea, Entisar, Elhadi, Muhammed, Abujamra, Saleh, A Msherghi, Ahmed, E Tababa, Osama W, A Majbar, Mohammed, Souadka, Amine, Benkabbou, Amine, Mohsine, Raouf, Echiguer, Sabrillah, Moctezuma-Velázquez, Paulina, Salgado-Nesme, Noel, Vergara-Fernández, Omar, C Sainz-Hernández, Juan, E Alvarez-Bautista, Francisco, D Zakaria, Andee, Zakaria, Zaidi, K Wong, Michael P, Ismail, Razif, F Ibrahim, Aini, N Abdullah, Nik A, Julaihi, Rokayah, Bhat, Sameer, O'Grady, Greg, Bissett, Ian, Lamme, Ba, D Musters, Gijsbert, M Dinaux, Anne, A Grotenhuis, Brechtje, J Aalbers, Ernst J Steller Arend G, M Leeuwenburgh, Marjolein, T Rutten, Harm J, A Burger, Jacobus W, G Bloemen, Johanne, J Ketelaers, Stijn H, Waqar, Usama, Chawla, Tabish, Rauf, Hareem, Rani, Pallavi, K Talsma, Aaldert, Scheurink, Lieke, B van Praagh, Jasper, Segelman, Josefin, Nygren, Jona, Anderin, Kajsa, Tiefenthal, Marit, de Andrés, Beatriz, P Beltrán de Heredia, Juan, Vázquez, Andrea, Gómez, Tania, Golshani, Parisa, Kader, Rawaz, Mohamed, Abudi, Westerterp, Marinke, Marinelli, Andrea, Niemer, Quirine, G Doornebosch, Pascal, Shapiro, Joël, Vermaas, Maarten, R de Graaf, Eelco J, L van Westreenen, Hendrik, Zwakman, Marije, D van Dalsen, Annette, J Vles, Wouter, Nonner, Joost, R Toorenvliet, Boudewijn, J Janssen, Paul T, G Verdaasdonk, Emiel G, J Amelung, Femke, R Bahadoer, Koen C M J Peeters Renu, A Holman, Fabian, Heemskerk, Jeroen, Vosbeek, Noortje, A Leijtens, Jeroen W, M Taverne, Sophie B, M Heijnen, Bob H, El-Massoudi, Youssef, de Groot-van Veen, Irene, Hoff, Christiaan, Jou-Valencia, Daniela, A Burghgraef, Esther C J Consten Thij, Geitenbeek, Ritch, L Hulshof, Lorenzo G W, D Slooter, Gerrit, Reudink, Muriël, D Bouvy, Nicole, L Wildeboer, Aurelia C, Verstappen, Sonja, J Pennings, Alexander, van den Hengel, Berber, G Wijma, Allard, de Haan, Jael, F de Nes, Lindsey C, Heesink, Vera, Karsten, Tom, M Heidsma, Charlotte, J Koemans, Willem, T Dekker, Jan-Willem, J van der Zijden, Charlène, Roos, Daphne, Demirkiran, Ahmet, van der Burg, Sjirk, J Oosterling, Steven, J Hoogteijling, Tij, Wiering, Bastiaan, J Smeeing, Diederik P, Havenga, Klaa, Lutfi, Hamid, J Consten, Esther C, Tsimogiannis, Konstantino, Sköldberg, Filip, Folkesson, Joakim, den Boer, Frank, G van Schaik, Ted, van Gerven, Pieter, Sietses, Colin, C Hol, Jeroen, G Boerma, Evert-Jan, J Creemers, Davy M, K Schultz, Johanne, Frivold, Tone, Riis, Rolf, Gregussen, Hilde, Busund, Sondre, H Sjo, Ole, Gaard, Maria, Krohn, Nina, L Ersryd, Amanda, Leung, Edmund, Sultan, Hytham, Nabil Hajjaj, Baraa, Jehad Alhisi, Ahmed, E Khader, Ahmed A, Filipa Dias Mendes, Ana, Semião, Miguel, Queiroz Faria, Lui, Azevedo, Constança, M da Costa Devesa, Helena, Fortuna Martins, Sónia, M Rodrigues Jarimba, Aldo, M Ribeiro Marques, Sónia, Marques Ferreira, Rita, Oliveira, António, Ferreira, Cátia, Pereira, Ricardo, M Surlin, Valeriu, M Graure, Giorgiana, D Ramboiu, Stefan Patrascu Sandu, Negoi, Ionut, Ciubotaru, Cezar, Stoica, Bogdan, Tanase, Ioan, M Negoita, Valentina, Florea, Sabrina, Macau, Florin, Vasile, Mihai, Stefanescu, Victor, Dimofte, Gabriel-Mihail, Luncă, Sorinel, Roată, Cristian-Ene, Mușină, Ana-Maria, Garmanova, Tatiana, N Agapov, Mikhail, G Markaryan, Daniil, Eduard, Galliamov, Yanishev, Alexey, Abelevich, Alexander, Bazaev, Andrey, V Rodimov, Sergey, B Filimonov, Victor, A Melnikov, Andrey, A Suchkov, Igor, S Drozdov, Evgeniy, N Kostromitskiy, Dmitriy, Sjöström, Olle, Matthiessen, Peter, Baban, Bayar, Gadan, Soran, Dehlaghi Jadid, Kaveh, Staffan, Maria, M Park, Jennifer, Rydbeck, Daniel, Lydrup, Marie-Louise, Buchwald, Pamela, Jutesten, Henrik, Darlin, Lotten, Lindqvist, Ebba, Nilsson, Karl, Larsson, Per-Ander, Jangmalm, Staffan, A Košir, Jurij, Tomažič, Aleš, Grosek, Jan, Košir Božič, Tajda, Zazo, Aya, Zazo, Rama, Fares, Hala, Ayoub, Kusay, Niazi, Ammar, Mansour, Ali, Abbas, Ayman, Tantoura, Mohammad, Hamdan, Alaa, Hassan, Naya, Hasan, Bassam, Saad, Ahmad, Sebai, Amine, Haddad, Ani, Maghrebi, Houcine, Kacem, Montasser, Yalkın, Ömer, Veysi Samsa, Mehmet, Atak, İbrahim, Balci, Bengi, Haberal, Elifcan, Dogan, Lütfi, E Gecim, Ibrahim, Akyol, Cihangir, A Koc, Mehmet, Sivrikoz, Emre, Piyadeoğlu, Deniz, O Avanagh, Dara, Sökmen, Selman, Bişgin, Tayfun, Günenç, Erşan, Güzel, Melek, Leventoğlu, Sezai, Yüksel, Osman, Kozan, Ramazan, Göbüt, Hüseyin, Cengiz, Fevzi, Erdinc, Kemal, Coşgun Acar, Nihan, Kamer, Erdinc, Özgür, İlker, Aydın, Oguzhan, Keskin, Metin, Türker Bulut, Mehmet, B Kulle, Cemil, Kara, Yasin, Sıbıç, Osman, H Özata, İbrahim, Buğra, Dursun, Balık, Emre, Çakır, Murat, Alhardan, Ana, Colak, Elif, B CiftciEngin Aybar, Ahmet, Can Sari, Ahmet, Demirli Atici, Semra, Kaya, Tayfun, Dursun, Ayberk, Calik, Bulent, Faruk Özkan, Ömer, Şeyda Ülgür, Hanife, Düzgün, Özgül, Monson, John, George, Sarah, Woods, Kayla, Al-Eryani, Fatima, Albakry, Rudaina, Coetzee, Emile, Boutall, Adam, Herman, Ayesiga, Warden, Claire, Mugla, Naser, Forgan, Tim, Mia, Imraan, Lambrechts, Anton, Roberto Persiani (ORCID:0000-0002-1537-5097), Alberto Biondi (ORCID:0000-0002-2470-7858), Roberto Pezzuto, Laura Lorenzon (ORCID:0000-0001-6736-0383), Gianluca Rizzo, and Claudio Coco (ORCID:0000-0002-4713-7093)
- Abstract
Background The optimal treatment of anastomotic leak after rectal cancer resection is unclear. This worldwide cohort study aimed to provide an overview of four treatment strategies applied.Methods Patients from 216 centres and 45 countries with anastomotic leak after rectal cancer resection between 2014 and 2018 were included. Treatment was categorized as salvage surgery, faecal diversion with passive or active (vacuum) drainage, and no primary/secondary faecal diversion. The primary outcome was 1-year stoma-free survival. In addition, passive and active drainage were compared using propensity score matching (2 : 1).Results Of 2470 evaluable patients, 388 (16.0 per cent) underwent salvage surgery, 1524 (62.0 per cent) passive drainage, 278 (11.0 per cent) active drainage, and 280 (11.0 per cent) had no faecal diversion. One-year stoma-free survival rates were 13.7, 48.3, 48.2, and 65.4 per cent respectively. Propensity score matching resulted in 556 patients with passive and 278 with active drainage. There was no statistically significant difference between these groups in 1-year stoma-free survival (OR 0.95, 95 per cent c.i. 0.66 to 1.33), with a risk difference of -1.1 (95 per cent c.i. -9.0 to 7.0) per cent. After active drainage, more patients required secondary salvage surgery (OR 2.32, 1.49 to 3.59), prolonged hospital admission (an additional 6 (95 per cent c.i. 2 to 10) days), and ICU admission (OR 1.41, 1.02 to 1.94). Mean duration of leak healing did not differ significantly (an additional 12 (-28 to 52) days).Conclusion Primary salvage surgery or omission of faecal diversion likely correspond to the most severe and least severe leaks respectively. In patients with diverted leaks, stoma-free survival did not differ statistically between passive and active drainage, although the increased risk of secondary salvage surgery and ICU admission suggests residual confounding.The optimal treatment strategy for anastomotic leakage after restorative rectal cancer su
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- 2023
17. Long-term Quality of Life and Functional Outcome of Patients With Rectal Cancer Following a Watch-and-Wait Approach
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Custers, Petra A., van der Sande, Marit E., Grotenhuis, Brechtje A., Peters, Femke P., van Kuijk, Sander M. J., Beets, Geerard L., Breukink, Stephanie O., Dutch Watch & Wait Consortium, Custers, Petra A., van der Sande, Marit E., Grotenhuis, Brechtje A., Peters, Femke P., van Kuijk, Sander M. J., Beets, Geerard L., Breukink, Stephanie O., and Dutch Watch & Wait Consortium
- Abstract
IMPORTANCE A watch-and-wait approach for patients with rectal cancer and a clinical complete response after neoadjuvant chemoradiotherapy or radiotherapy is associated with better quality of life and functional outcome. Nevertheless, prospective data on both parameters are scarce.OBJECTIVE To prospectively evaluate quality of life and functional outcome, including bowel, urinary, and sexual function, of patients following a watch-and-wait approach. DESIGN, SETTING, AND PARTICIPANTS A total of 278 patients with rectal cancer and a clinical complete response or near-complete response after neoadjuvant chemoradiotherapy or radiotherapy were included in 2 prospective cohort studies: a single-center study (March 2014 to October 2017) and an ongoing multicenter study (from September 2017). Patients were observed by a watch-and-wait approach. Additional local excision or total mesorectal excision was performed for residual disease or regrowth. Data were analyzed between April 1, 2021, and August 27, 2021, for patients with a minimum follow-up of 24 months.MAIN OUTCOMES AND MEASURES Quality of life was evaluated with the European Organisation for Research and Treatment of Cancer-Quality of Life Questionnaire-C30 (EORTC-QLQ-C30), EORTC-QLQ-CR38, or EORTC-QLQ-CR29 and 36-Item Short-Form Health Survey. The score for the questionnaires and 36-Item Short-Form Health Survey ranges from 0 to 100. For some scales, a high score indicates a high level of functioning, and for others it indicates a high level of complaints and symptomatology. Functional outcome was assessed by the Low Anterior Resection Syndrome score, Vaizey incontinence score, International Prostate Symptom Score, International Index of Erectile Function, and Female Sexual Function Index.RESULTS Of 278 patients included, 187 were male (67%), and the median age was 66 years (range, 34-85 years). In the first 24 months, 221 patients (80%) were observed by a watch-and-wait approach without requiring surgery, 18 patients
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- 2023
18. Imaging Photoplethysmography for Noninvasive Anastomotic Perfusion Assessment in Intestinal Surgery
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van der Stel, Stefan D. (author), Lai, Marco (author), Groen, Harald C. (author), Witteveen, Mark (author), Kuhlmann, Koert F.D. (author), Grotenhuis, Brechtje A. (author), Kok, Niels F.M. (author), van Gastel, Mark (author), Hendriks, B.H.W. (author), Ruers, Theo J.M. (author), van der Stel, Stefan D. (author), Lai, Marco (author), Groen, Harald C. (author), Witteveen, Mark (author), Kuhlmann, Koert F.D. (author), Grotenhuis, Brechtje A. (author), Kok, Niels F.M. (author), van Gastel, Mark (author), Hendriks, B.H.W. (author), and Ruers, Theo J.M. (author)
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Introduction: Anastomotic leakage after gastrointestinal surgery has a high impact on patient's quality of life and its origin is associated with inadequate perfusion. Imaging photoplethysmography (iPPG) is a noninvasive imaging technique that measures blood-volume changes in the microvascular tissue bed and detects changes in tissue perfusion. Materials and methods: Intraoperative iPPG imaging was performed in 29 patients undergoing an open segment resection of the small intestine or colon. During each surgery, imaging was performed on fully perfused (true positives) and ischemic intestines (true negatives) and the anastomosis (unknowns). Imaging consisted of a 30-s video from which perfusion maps were extracted, providing detailed information about blood flow within the intestine microvasculature. To detect the predictive capabilities of iPPG, true positive and true negative perfusion conditions were used to develop two different perfusion classification methods. Results: iPPG-derived perfusion parameters were highly correlated with perfusion—perfused or ischemic—in intestinal tissues. A perfusion confidence map distinguished perfused and ischemic intestinal tissues with 96% sensitivity and 86% specificity. Anastomosis images were scored as adequately perfused in 86% of cases and 14% inconclusive. The cubic-Support Vector Machine achieved 90.9% accuracy and an area under the curve of 96%. No anastomosis-related postoperative complications were encountered in this study. Conclusions: This study shows that noninvasive intraoperative iPPG is suitable for the objective assessment of small intestine and colon anastomotic perfusion. In addition, two perfusion classification methods were developed, providing the first step in an intestinal perfusion prediction model., Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public., Medical Instruments & Bio-Inspired Technology
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- 2023
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19. Towards Response ADAptive Radiotherapy for organ preservation for intermediate-risk rectal cancer (preRADAR): protocol of a phase I dose-escalation trial
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Trialbureau Beeld, Cancer, MS CGO, MS MDL 1, MS Medische Oncologie, Pathologie Pathologen staf, MS Radiologie, Epi Kanker Team C, JC onderzoeksprogramma Kanker, Klinische Fysica RT, MS Radiotherapie, Verweij, Maaike E, Tanaka, Max D, Kensen, Chavelli M, van der Heide, Uulke A, Marijnen, Corrie A M, Janssen, Tomas, Vijlbrief, Tineke, van Grevenstein, Wilhelmina M U, Moons, Leon M G, Koopman, Miriam, Lacle, Miangela M, Braat, Manon N G J A, Chalabi, Myriam, Maas, Monique, Huibregtse, Inge L, Snaebjornsson, Petur, Grotenhuis, Brechtje A, Fijneman, Remond, Consten, Esther, Pronk, Apollo, Smits, Anke B, Heikens, Joost T, Eijkelenkamp, Hidde, Elias, Sjoerd G, Verkooijen, Helena M, Schoenmakers, Maartje M C, Meijer, Gert J, Intven, Martijn, Peters, Femke P, Trialbureau Beeld, Cancer, MS CGO, MS MDL 1, MS Medische Oncologie, Pathologie Pathologen staf, MS Radiologie, Epi Kanker Team C, JC onderzoeksprogramma Kanker, Klinische Fysica RT, MS Radiotherapie, Verweij, Maaike E, Tanaka, Max D, Kensen, Chavelli M, van der Heide, Uulke A, Marijnen, Corrie A M, Janssen, Tomas, Vijlbrief, Tineke, van Grevenstein, Wilhelmina M U, Moons, Leon M G, Koopman, Miriam, Lacle, Miangela M, Braat, Manon N G J A, Chalabi, Myriam, Maas, Monique, Huibregtse, Inge L, Snaebjornsson, Petur, Grotenhuis, Brechtje A, Fijneman, Remond, Consten, Esther, Pronk, Apollo, Smits, Anke B, Heikens, Joost T, Eijkelenkamp, Hidde, Elias, Sjoerd G, Verkooijen, Helena M, Schoenmakers, Maartje M C, Meijer, Gert J, Intven, Martijn, and Peters, Femke P
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- 2023
20. Whole‐body MRI with diffusion‐weighted imaging as an adjunct to18F‐fluorodeoxyglucose positron emission tomography and CT in patients with suspected recurrent colorectal cancer.
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Willemse, Jeroen R. J., Lahaye, Max J., Kok, Niels F. M., Grotenhuis, Brechtje A., Aalbers, Arend G. J., Beets, Geerard L., Rijsemus, Charlotte, Maas, Monique, van Golen, Larissa W., Beets‐Tan, Regina G. H., and Lambregts, Doenja M. J.
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POSITRON emission tomography computed tomography ,DIFFUSION magnetic resonance imaging ,MAGNETIC resonance imaging ,COLORECTAL cancer ,POSITRON emission tomography - Abstract
Aim: The aim was to explore how findings of whole‐body MRI including diffusion‐weighted imaging (DW‐MRI) compared to the routine diagnostic workup with CT and/or 18F‐fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT in patients with suspected recurrent colorectal cancer (CRC). Method: This was an exploratory retrospective analysis of 55 patients with a clinical suspicion of recurrent CRC who underwent DW‐MRI following CT and/or FDG‐PET/CT. Two readers in consensus interpreted all clinical imaging reports and converted each described lesion into a confidence score (1 = definitely benign to 5 = definitely malignant). DW‐MRI findings were compared to the most recent previous CT or PET/CT. Any discrepant or additional DW‐MRI findings were documented and compared with histology and/or clinical follow‐up (if available). Results: Whole‐body MRI including diffusion‐weighted imaging (DW‐MRI) resulted in discrepant/additional findings in 26/55 (47%) cases; 23/37 (62%) compared to previous CT and 3/18 (17%) compared to previous PET/CT. These included 10 cases where DW‐MRI converted previously inconclusive CT (n = 8) or PET/CT (n = 2) findings into a conclusive diagnosis, one where it contradicted a previous CT diagnosis of recurrence, five where DW‐MRI diagnosed recurrent disease not previously reported on CT and 10 cases where DW‐MRI detected additional lesions compared to CT (n = 9) or PET/CT (n = 1). Eighty‐eight per cent of cases with discrepant/additional findings concerned patients with recurrent/metachronous peritoneal metastases. In total, DW‐MRI resulted in 42 discrepant/additional lesions; the DW‐MRI diagnosis was correct in 76% of these lesions and incorrect (false positive) in 7%. In the remaining 17%, no standard of reference was available. Conclusions: This explorative study suggests that DW‐MRI may be of added value to patients with a clinical suspicion for recurrent CRC, in particular to identify patients with peritoneal metastases. DW‐MRI mainly has potential as a 'problem‐solver' in patients with inconclusive or negative findings on previous imaging (in particular CT) and to detect additional disease sites in patients already diagnosed with recurrent disease. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Towards Response ADAptive Radiotherapy for organ preservation for intermediate-risk rectal cancer (preRADAR): protocol of a phase I dose-escalation trial
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Verweij, Maaike E, primary, Tanaka, Max D, additional, Kensen, Chavelli M, additional, van der Heide, Uulke A, additional, Marijnen, Corrie A M, additional, Janssen, Tomas, additional, Vijlbrief, Tineke, additional, van Grevenstein, Wilhelmina M U, additional, Moons, Leon M G, additional, Koopman, Miriam, additional, Lacle, Miangela M, additional, Braat, Manon N G J A, additional, Chalabi, Myriam, additional, Maas, Monique, additional, Huibregtse, Inge L, additional, Snaebjornsson, Petur, additional, Grotenhuis, Brechtje A, additional, Fijneman, Remond, additional, Consten, Esther, additional, Pronk, Apollo, additional, Smits, Anke B, additional, Heikens, Joost T, additional, Eijkelenkamp, Hidde, additional, Elias, Sjoerd G, additional, Verkooijen, Helena M, additional, Schoenmakers, Maartje M C, additional, Meijer, Gert J, additional, Intven, Martijn, additional, and Peters, Femke P, additional
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- 2023
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22. Selected stage IV rectal cancer patients managed by the watch-and-wait approach after pelvic radiotherapy
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Custers, Petra A., Hupkens, Britt J.P., Grotenhuis, Brechtje A., Kuhlmann, Koert F.D., Breukink, Stephanie O., Beets, Geerard L., Melenhorst, Jarno, Komen, Niels, Dutch Watch-and- Wait Consortium, Dutch Watch-and- Wait Consortium, Surgery, CCA - Cancer Treatment and quality of life, Amsterdam Gastroenterology Endocrinology Metabolism, CCA - Cancer Treatment and Quality of Life, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, School Office GROW, MUMC+: MA Heelkunde (9), RS: NUTRIM - R2 - Liver and digestive health, RS: GROW - R1 - Prevention, and Faculteit FHML Centraal
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watch-and-wait ,OUTCOMES ,oncological outcome ,Gastroenterology ,POLICY ,THERAPY ,CLINICAL COMPLETE RESPONDERS ,COLORECTAL-CANCER ,NEOADJUVANT CHEMORADIATION ,organ-preservation ,SURVIVAL ,Human medicine ,rectal cancer ,metastatic disease - Abstract
Aim The aim of this study was to assess the clinical and oncological outcome of a selected group of stage IV rectal cancer patients managed by the watch-and-wait approach following a (near-)complete response of the primary rectal tumour after radiotherapy. Method Patients registered in the Dutch watch-and-wait registry since 2004 were selected when diagnosed with synchronous stage IV rectal cancer. Data on patient characteristics, treatment details, follow-up and survival were collected. The 2-year local regrowth rate, organ-preservation rate, colostomy-free rate, metastatic progression-free rate and 2- and 5-year overall survival were analysed. Results After a median follow-up period of 35 months, local regrowth was observed in 17 patients (40.5%). Nine patients underwent subsequent total mesorectal excision, resulting in a permanent colostomy in four patients. The 2-year local regrowth rate was 39.9%, the 2-year organ-preservation rate was 77.1%, the 2-year colostomy-free rate was 88.1%, and the 2-year metastatic progression-free rate was 46.7%. The 2- and 5-year overall survival rates were 92.0% and 67.5%. Conclusion The watch-and-wait approach can be considered as an alternative to total mesorectal excision in a selected group of stage IV rectal cancer patients with a (near-)complete response following pelvic radiotherapy. Despite a relatively high regrowth rate, total mesorectal excision and a permanent colostomy can be avoided in the majority of these patients.
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- 2022
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23. Optimal Surgical Approach to Esophagectomy for Cancer
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Grotenhuis, Brechtje A., L. Wijnhoven, Bas P., van Lanschot, Jan J. B., and Ferguson, Mark K., editor
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- 2011
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24. Correction: Groen et al. Use of Image-Guided Surgical Navigation during Resection of Locally Recurrent Rectal Cancer. Life 2022, 12, 645
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Groen, Harald C., primary, den Hartog, Anne G., additional, Heerink, Wouter J., additional, Kuhlmann, Koert F. D., additional, Kok, Niels F. M., additional, van Veen, Ruben, additional, Hiep, Marijn A. J., additional, Snaebjornsson, Petur, additional, Grotenhuis, Brechtje A., additional, Beets, Geerard L., additional, Aalbers, Arend G. J., additional, and Ruers, Theo J. M., additional
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- 2023
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25. Locoregional nodal regrowth in rectal cancer patients following a Watch-and-Wait approach: a clinical challenge?
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Geubels, Barbara, primary, Custers, Petra, additional, Maas, Monique, additional, Beets, Geerard, additional, and Grotenhuis, Brechtje, additional
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- 2023
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26. Radiotherapy, atezolizumab, and bevacizumab in rectal cancers with the aim of organ preservation: The TARZAN study.
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Verschoor, Yara L., primary, Lambregts, Doenja M. J., additional, van den Berg, José, additional, Grotenhuis, Brechtje A., additional, Aalbers, Arend, additional, Van Triest, Baukelien, additional, Beets-Tan, Regina G.H., additional, van de Belt, Marieke, additional, Dokter, Simone, additional, Balduzzi, Sara, additional, Voest, Emile E., additional, Haanen, John B. A. G., additional, van Leerdam, Monique E., additional, Beets, Geerard, additional, and Chalabi, Myriam, additional
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- 2023
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27. Role of local excision for suspected regrowth in a Watch and Wait strategy for rectal cancer
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Geubels, Barbara, primary, Meyer, Vincent, additional, van Westreenen, Henderik, additional, Beets, Geerard, additional, and Grotenhuis, Brechtje, additional
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- 2023
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28. The Pathogenesis of Barrett’s Metaplasia and the Progression to Esophageal Adenocarcinoma
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Grotenhuis, Brechtje A., van Lanschot, J. Jan B., Dinjens, Winand N. M., Wijnhoven, Bas P. L., and Schneider, Paul M., editor
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- 2010
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29. A personalized app to improve quality of life of patients with a stoma: A protocol for a multicentre randomized controlled trial.
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van der Storm, Sebastiaan L., Bemelman, Willem A., van Dieren, Susan, Schijven, Marlies P., Consten, Esther C. J., Govaert, Marc J. P. M., Tuynman, Jurriaan B., Oosterling, Steven J., Grotenhuis, Brechtje A., Smits, Anke B., Marsman, Hendrik A., Buskens, Christianne J., Hompes, Roel, Kusters, Miranda, van Rossem, Charles C., van Duyn, Eino B., De Nes, Lindsey C. F., Verdaasdonk, Emiel, de Vries Reilingh, Tammo S., and Vening, Wouter
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OSTOMATES ,PATIENT reported outcome measures ,RANDOMIZED controlled trials ,COLOSTOMY ,QUALITY of life ,ILEOSTOMY ,LENGTH of stay in hospitals - Abstract
Aim: Proper education, guidance and support is crucial before and following creation of a stoma. Patients with a stoma and their close relatives need to adapt to and cope with this new – and sometimes unforeseen – situation, which may result in insecurities and a variety of psychosocial problems. Self‐efficacy is associated both with a reduction in psychosocial problems and with improved quality of life. The main objective of this study was to investigate whether self‐reported quality of life of patients with a stoma can be enhanced by offering personalized and timed guidance, as well as peer contact, in a patient‐centred mobile application. Method: A multicentre, double‐blind, randomized controlled trial will be conducted. Consented adults >18 years of age who will receive an ileostomy or colostomy and possess an eligible smartphone will be included. The intervention group will be given the full version of the application (containing personalized and timed guidance, such as operation‐specific information and information on the associated care pathway) to install on their smartphone. In addition, the intervention group has access to a protected peer‐support platform within the app. The control group will receive a restricted version of the application that contains only generic (non‐personalized) stoma‐related information. The primary outcome is quality of life, 3 months postoperatively. Secondary outcomes are Patient Reported Outcome Measures (PROMs), such as psychological adaption, as well as number of complications, re‐admission and re‐operation rates and the length of hospital stay. Results: Patient enrolment began in March 2021. Data collection was not complete when this protocol was submitted. Conclusion: We hypothesize that patients with a stoma who are supported by the intervention version of the app will report a significantly higher quality of life than patients with a stoma who are supported by the control version of the app (ie, are not offered personalized and timed guidance and information and do not have access to peer support in the app). [ABSTRACT FROM AUTHOR]
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- 2023
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30. Sarcopenia/Muscle Mass is not a Prognostic Factor for Short- and Long-Term Outcome After Esophagectomy for Cancer
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Grotenhuis, Brechtje A., Shapiro, Joël, van Adrichem, Stefan, de Vries, Marianne, Koek, Marcel, Wijnhoven, Bas P. L., and van Lanschot, J. Jan B.
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- 2016
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31. The evaluation of follow-up strategies of watch-and-wait patients with a complete response after neoadjuvant therapy in rectal cancer
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Haak, Hester E., Zmuc, Jan, Lambregts, Doenja M.J., Beets‐Tan, Regina G.H., Melenhorst, Jarno, Beets, Geerard L., Maas, Monique, Breukink, Stephanie O., Festen, Sebastiaan, de Graaf, Eelco J.R., Grotenhuis, Brechtje A., Hilling, Denise, Hoff, Christiaan, Intven, Martijn, Komen, Niels, Peeters, Koen Cmj., Pronk, Apollo, Schreurs, Hermien W.H., Sonneveld, Dirk J.A., Talsma, Koen, Tuynman, Jurriaan B., Kusters, Miranda, van Westreenen, Henderik L., de Wilt, Johannes H.W., Zimmerman, David D.E., Dutch Watch‐and‐Wait Consortium, Surgery, CCA - Cancer Treatment and quality of life, Amsterdam Gastroenterology Endocrinology Metabolism, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Faculteit FHML Centraal, and MUMC+: MA Heelkunde (9)
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medicine.medical_specialty ,Schedule ,watch-and-wait ,Colorectal cancer ,medicine.medical_treatment ,Lumen (anatomy) ,chemoradiotherapy ,Very frequent ,Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] ,03 medical and health sciences ,0302 clinical medicine ,medicine ,follow-up ,Humans ,Watchful Waiting ,rectal cancer ,and‐ ,Neoadjuvant therapy ,Retrospective Studies ,follow‐ ,up ,medicine.diagnostic_test ,business.industry ,Rectal Neoplasms ,Gastroenterology ,medicine.disease ,Neoadjuvant Therapy ,Endoscopy ,watch‐ ,030220 oncology & carcinogenesis ,Cohort ,clinical complete response ,wait ,030211 gastroenterology & hepatology ,Radiology ,Human medicine ,Neoplasm Recurrence, Local ,organ preservation ,business ,Chemoradiotherapy ,Follow-Up Studies - Abstract
Aim Many of the current follow-up schedules in a watch-and-wait approach include very frequent MRI and endoscopy examinations to ensure early detection of local regrowth (LR). The aim of this study was to analyse the occurrence and detection of LR in a watch-and-wait cohort and to suggest a more efficient follow-up schedule. Method Rectal cancer patients with a clinical complete response after neoadjuvant therapy were prospectively and retrospectively included in a multicentre watch-and-wait registry between 2004 and 2018, with the current follow-up schedule with 3-monthly endoscopy and MRI in the first year and 6 monthly thereafter. A theoretical comparison was constructed for the detection of LR in the current follow-up schedule against four other hypothetical schedules. Results In all, 50/304 (16%) of patients developed a LR. The majority (98%) were detected at ≤2 years, located in the lumen (94%) and were visible on endoscopy (88%). The theoretical comparison of the different hypothetical schedules suggests that the optimal follow-up schedule should focus on the first 2 years with 3-monthly endoscopy and 3-6 monthly MRI. Longer intervals in the first 2 years will cause delays in diagnosis of LR ranging from 0 to 5 months. After 2 years, increasing the interval from 6 to 12 months did not cause important delays. Conclusion The optimal follow-up schedule for a watch-and-wait policy in patients with a clinical complete response after chemoradiation for rectal cancer should include frequent endoscopy and to a lesser degree MRI in the first 2 years. Longer intervals, up to 12 months, can be considered after 2 years.
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- 2021
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32. The HIPPO Trial, a Randomized Double-blind Trial Comparing Self-gripping Parietex Progrip Mesh and Sutured Parietex Mesh in Lichtenstein Hernioplasty: A Long-term Follow-up Study
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Molegraaf, Marijke J., Grotenhuis, Brechtje, Torensma, Bart, de Ridder, Victor, Lange, Johan F., and Swank, Dingeman J.
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- 2017
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33. Challenges and controversies patients and (health care) professionals experience in managing vaginal, vulvar, penile or anal cancer: The SILENCE study
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van Dongen, Jessy, primary, de Heus, Eline, additional, Eickholt, Lauren, additional, Schrieks, Marga, additional, Zantingh, Ilaniek, additional, Brouwer, Oscar R., additional, Oonk, Maaike H. M., additional, Grotenhuis, Brechtje A., additional, Ezendam, Nicole P. M., additional, and Duijts, Saskia F. A., additional
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- 2022
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34. Role of Local Excision for Suspected Regrowth in a Watch and Wait Strategy for Rectal Cancer
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Geubels, Barbara M, Meyer, Vincent M, van Westreenen, Henderik L, Beets, Geerard L, Grotenhuis, Brechtje A, On Behalf Of The Dutch Watch And Wait Consortium, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, School Office GROW, RS: GROW - R1 - Prevention, Faculteit FHML Centraal, and Faculteit Medische Wetenschappen/UMCG
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ORGAN PRESERVATION ,Cancer Research ,OUTCOMES ,Watch and Wait ,oncological outcome ,IMPACT ,rectal cancer ,local regrowth ,local excision ,organ preservation ,RADICAL SURGERY ,THERAPY ,Oncology ,NEOADJUVANT CHEMORADIATION ,TRANSANAL ENDOSCOPIC MICROSURGERY ,PREOPERATIVE RADIOTHERAPY - Abstract
Simple Summary Rectal cancer patients with a clinical complete response to neoadjuvant treatment are eligible for Watch and Wait as an alternative to total mesorectal excision. However, in patients with local regrowth, major surgery is still the standard of care. The present study evaluates the role of local excision for suspected local regrowth in a large Watch and Wait cohort, in terms of long-term outcomes. This study shows excellent overall survival and a good organ preservation rate. Patients who developed locoregional recurrence after initial local excision for regrowth were all successfully treated with salvage surgery. This study shows that local excision can provide maintenance of organ preservation without an obvious compromise in surgical or oncological safety. Local excision for suspected regrowth in patients following Watch and Wait can be a safe alternative for total mesorectal excision in selected patients with a strong wish to preserve their rectum. Rectal cancer patients with a clinical complete response to neoadjuvant (chemo)radiation are eligible for Watch and Wait (W&W). For local regrowth, total mesorectal excision (TME) is considered the standard of care. This study evaluated local excision (LE) for suspected local regrowth. From 591 patients prospectively entered into a national W&W registry, 77 patients with LE for regrowth were included. Outcomes analyzed included histopathologic findings, locoregional recurrence, long-term organ preservation, and colostomy-free and overall survival. In total, 27/77 patients underwent early LE (= 6 months). Median follow-up was 53 (39-69) months. In 28/77 patients the LE specimen was histopathologically classified as ypT0 (including 9 adenomas); 11/77 were ypT1, and 38/77 were ypT2-3. After LE, 13/77 patients with ypT2-3 and/or irradical resection underwent completion TME. Subsequently, 14/64 patients without completion TME developed locoregional recurrence, and were successfully treated with salvage TME. Another 8/77 patients developed distant metastases. At 5 years, overall organ preservation was 63%, colostomy-free survival was 68%, and overall survival was 96%. There were no differences in outcomes between early or late LE. In W&W for rectal cancer, LE can be considered as an alternative to TME for suspected regrowth in selected patients who wish to preserve their rectum or avoid colostomy in distal rectal cancer.
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- 2022
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35. Selected stage IV rectal cancer patients managed by the watch-and-wait approach after pelvic radiotherapy:a good alternative to total mesorectal excision surgery?
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Custers, Petra A., Hupkens, Britt J.P., Grotenhuis, Brechtje A., Kuhlmann, Koert F.D., Breukink, Stéphanie O., Beets, Geerard L., Melenhorst, Jarno, Custers, Petra A., Hupkens, Britt J.P., Grotenhuis, Brechtje A., Kuhlmann, Koert F.D., Breukink, Stéphanie O., Beets, Geerard L., and Melenhorst, Jarno
- Abstract
Aim: The aim of this study was to assess the clinical and oncological outcome of a selected group of stage IV rectal cancer patients managed by the watch-and-wait approach following a (near-)complete response of the primary rectal tumour after radiotherapy. Method: Patients registered in the Dutch watch-and-wait registry since 2004 were selected when diagnosed with synchronous stage IV rectal cancer. Data on patient characteristics, treatment details, follow-up and survival were collected. The 2-year local regrowth rate, organ-preservation rate, colostomy-free rate, metastatic progression-free rate and 2- and 5-year overall survival were analysed. Results: After a median follow-up period of 35 months, local regrowth was observed in 17 patients (40.5%). Nine patients underwent subsequent total mesorectal excision, resulting in a permanent colostomy in four patients. The 2-year local regrowth rate was 39.9%, the 2-year organ-preservation rate was 77.1%, the 2-year colostomy-free rate was 88.1%, and the 2-year metastatic progression-free rate was 46.7%. The 2- and 5-year overall survival rates were 92.0% and 67.5%. Conclusion: The watch-and-wait approach can be considered as an alternative to total mesorectal excision in a selected group of stage IV rectal cancer patients with a (near-)complete response following pelvic radiotherapy. Despite a relatively high regrowth rate, total mesorectal excision and a permanent colostomy can be avoided in the majority of these patients.
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- 2022
36. Challenges and controversies patients and (health care) professionals experience in managing vaginal, vulvar, penile or anal cancer: The SILENCE study
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van Dongen, Jessy, de Heus, Eline, Eickholt, Lauren, Schrieks, Marga, Zantingh, Ilaniek, Brouwer, Oscar R, Oonk, Maaike H M, Grotenhuis, Brechtje A, Ezendam, Nicole P M, Duijts, Saskia F A, van Dongen, Jessy, de Heus, Eline, Eickholt, Lauren, Schrieks, Marga, Zantingh, Ilaniek, Brouwer, Oscar R, Oonk, Maaike H M, Grotenhuis, Brechtje A, Ezendam, Nicole P M, and Duijts, Saskia F A
- Abstract
Objective: Patients with vaginal, vulvar, penile or anal cancer experience deteriorated psychosocial functioning and decreased Quality of Life (QoL). The aims of this study were to explore (1) the challenges and controversies patients experience in managing vaginal, vulvar, penile or anal cancer; their unmet needs; and how this affects their psychosocial functioning and (2) the gaps health care professionals (HCPs) experience in providing psychosocial support and potential improvements in care.METHODS: Semi-structured interviews with patients with vaginal, vulvar, penile or anal cancer and with HCPs were conducted. All interviews were transcribed verbatim and thematically analysed.Results: Fourteen patients (86% female; mean age 55.5) and 12 HCPs (75% female; mean age 46.4) participated. Four themes were identified: (1) recognisable symptoms but unfamiliar diagnosis, (2) 'double hit' has severe impact on psychosocial functioning, (3) personal and tailored information is important but not guaranteed and (4) all-encompassing care to improve psychosocial functioning and QoL.Conclusion: Patients with vaginal, vulvar, penile or anal cancer encounter a lack of awareness and knowledge about their rare cancer type, difficulties regarding communication and long-term changes in body image and sexuality. Awareness of symptoms should be raised and psychosocial care should be offered on a structural basis.
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- 2022
37. Use of Image-Guided Surgical Navigation during Resection of Locally Recurrent Rectal Cancer
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Groen, Harald C., primary, den Hartog, Anne G., additional, Heerink, Wouter J., additional, Kuhlmann, Koert F. D., additional, Kok, Niels F. M., additional, van Veen, Ruben, additional, Hiep, Marijn A. J., additional, Snaebjornsson, Petur, additional, Grotenhuis, Brechtje A., additional, Beets, Geerard L., additional, Aalbers, Arend G. J., additional, and Ruers, Theo J. M., additional
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- 2022
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38. Delay in Diagnostic Workup and Treatment of Esophageal Cancer
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Grotenhuis, Brechtje A., van Hagen, Pieter, Wijnhoven, Bas P.L., Spaander, Manon C.W., Tilanus, Hugo W., and van Lanschot, Jan J.B.
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- 2010
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39. Validation of a Nomogram Predicting Complications After Esophagectomy for Cancer
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Grotenhuis, Brechtje A., van Hagen, Pieter, Reitsma, Johannes B., Lagarde, Sjoerd M., Wijnhoven, Bas P.L., van Berge Henegouwen, Mark I., Tilanus, Hugo W., and van Lanschot, J. Jan B.
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- 2010
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40. Quality of life and functional outcome of rectal cancer patients following a Watch-and-Wait approach.
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Custers, Petra, primary, van der Sande, Marit, additional, Grotenhuis, Brechtje, additional, Peters, Femke, additional, van Kuijk, Sander, additional, Breukink, Stephanie, additional, and Beets, Geerard, additional
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- 2022
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41. Long-Term Quality of Life and Functional Outcome of Rectal Cancer Patients Following a Watch-and-Wait Approach: A Prospective Cohort Study
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Custers, Petra A., primary, van der Sande, Marit E., additional, Grotenhuis, Brechtje A., additional, Peters, Femke P., additional, van Kuijk, Sander, additional, Beets, Geerard L., additional, and Breukink, Stéphanie O., additional
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- 2022
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42. The sigmoid take-off as a landmark to distinguish rectal from sigmoid tumours on MRI: Reproducibility, pitfalls and potential impact on treatment stratification
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Bogveradze, Nino, primary, Lambregts, Doenja M.J., additional, el Khababi, Najim, additional, Dresen, Raphaëla C., additional, Maas, Monique, additional, Kusters, Miranda, additional, Tanis, Pieter J., additional, Beets-Tan, Regina G.H., additional, Alberts, Femke, additional, Bakers, Frans C.H., additional, Batiashvili, Nino, additional, Beets, Geerard L., additional, de Bie, Shira, additional, Bogveradze, Nino, additional, Bosma, Gerlof, additional, Cappendijk, Vincent C., additional, Castagnoli, Francesca, additional, Daushvili, Ana, additional, Doornebosch, Pascal, additional, Geenen, Remy, additional, Grotenhuis, Brechtje, additional, Jokharidze, Tedo, additional, Lahaye, Max J., additional, Landolfi, Federica, additional, Leeuwenburgh, Marjolein, additional, Neijenhuis, Peter, additional, Peterson, Gerald, additional, Steller, Ernst J.A., additional, Veeken, Cornelis J., additional, De Vuysere, Sofie, additional, Vermaas, Maarten, additional, Vliegen, Roy F.A., additional, and Wolthuis, Albert, additional
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- 2022
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43. The sentinel node concept in adenocarcinomas of the distal esophagus and gastroesophageal junction
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Grotenhuis, Brechtje A., Wijnhoven, Bas P.L., van Marion, Ronald, van Dekken, Herman, Hop, Wim C., Tilanus, Hugo W., van Lanschot, J. Jan B., and van Eijck, Casper H.J.
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- 2009
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44. Preoperative Assessment of Tumor Location and Station-Specific Lymph Node Status in Patients with Adenocarcinoma of the Gastroesophageal Junction
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Grotenhuis, Brechtje A., Wijnhoven, Bas P. L., Poley, Jan Werner, Hermans, John J., Biermann, Katharina, Spaander, Manon C. W., Bruno, Marco J., Tilanus, Hugo W., and van Lanschot, J. Jan B.
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- 2013
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45. Comparison of the 6th and 7th Editions of the UICC-AJCC TNM Classification for Esophageal Cancer
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Talsma, Koen, van Hagen, Pieter, Grotenhuis, Brechtje A., Steyerberg, Ewout W., Tilanus, Hugo W., van Lanschot, Jan J. B., and Wijnhoven, Bas P. L.
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- 2012
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46. Inter- and intraobserver variation in the histopathological evaluation of early oesophageal adenocarcinoma
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Grotenhuis, Brechtje A., van Heijl, Mark, ten Kate, Fiebo J.W., Biermann, Katharina, Offerhaus, G. Johan A., Wijnhoven, Bas P.L., van Berge Henegouwen, Mark I., Tilanus, Hugo W., and van Lanschot, J. Jan B.
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Esophageal cancer -- Diagnosis ,Esophageal cancer -- Research ,Adenocarcinoma -- Diagnosis ,Adenocarcinoma -- Research ,Tumor staging -- Methods ,Tumor staging -- Quality management ,Tumor staging -- Research ,Examinations -- Validity ,Examinations -- Research ,Health - Published
- 2010
47. Defining a Learning Curve for Laparoscopic Cardiomyotomy
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Grotenhuis, Brechtje A., Wijnhoven, Bas P. L., Jamieson, Glyn G., Devitt, Peter G., Bessell, Justin R., and Watson, David I.
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- 2008
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48. Laparoscopic antireflux surgery in the elderly
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Grotenhuis, Brechtje A., Wijnhoven, Bas P. L., Bessell, Justin R., and Watson, David I.
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- 2008
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49. Reoperation for dysphagia after cardiomyotomy for achalasia
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Grotenhuis, Brechtje A., Wijnhoven, Bas P.L., Myers, Jennifer C., Jamieson, Glyn G., Devitt, Peter G., and Watson, David I.
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- 2007
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50. Optimal Surgical Approach to Esophagectomy for Cancer
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Grotenhuis, Brechtje A., primary, L. Wijnhoven, Bas P., additional, and van Lanschot, Jan J. B., additional
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- 2010
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