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1. From isolated light-harvesting complexes to the thylakoid membrane: a single-molecule perspective

Author

Gruber J. Michael, Malý Pavel, Krüger Tjaart P.J., and Grondelle Rienk van

Subjects
single-molecule spectroscopy, lipid environment, protein disorder, fluorescence lifetime, light-harvesting, photosystem ii, fluorescence blinking, Physics, QC1-999
Abstract

The conversion of solar radiation to chemical energy in plants and green algae takes place in the thylakoid membrane. This amphiphilic environment hosts a complex arrangement of light-harvesting pigment-protein complexes that absorb light and transfer the excitation energy to photochemically active reaction centers. This efficient light-harvesting capacity is moreover tightly regulated by a photoprotective mechanism called non-photochemical quenching to avoid the stress-induced destruction of the catalytic reaction center. In this review we provide an overview of single-molecule fluorescence measurements on plant light-harvesting complexes (LHCs) of varying sizes with the aim of bridging the gap between the smallest isolated complexes, which have been well-characterized, and the native photosystem. The smallest complexes contain only a small number (10–20) of interacting chlorophylls, while the native photosystem contains dozens of protein subunits and many hundreds of connected pigments. We discuss the functional significance of conformational dynamics, the lipid environment, and the structural arrangement of this fascinating nano-machinery. The described experimental results can be utilized to build mathematical-physical models in a bottom-up approach, which can then be tested on larger in vivo systems. The results also clearly showcase the general property of biological systems to utilize the same system properties for different purposes. In this case it is the regulated conformational flexibility that allows LHCs to switch between efficient light-harvesting and a photoprotective function.

Published
2018
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2. VLBI Celestial and Terrestrial Reference Frames VIE2022b

Author

Krásná, H., Baldreich, L., Böhm, J., Böhm, S., Gruber, J., Hellerschmied, A., Jaron, F., Kern, L., Mayer, D., Nothnagel, A., Panzenböck, O., and Wolf, H.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Geophysics
Abstract

Context: We introduce the computation of global reference frames from Very Long Baseline Interferometry (VLBI) observations at the Vienna International VLBI Service for Geodesy and Astrometry (IVS) Analysis Center (VIE) in detail. We focus on the celestial and terrestrial frames from our two latest solutions VIE2020 and VIE2022b. Aims: The current International Celestial and Terrestrial Reference Frames, ICRF3 and ITRF2020, include VLBI observations until spring 2018 and December 2020, respectively. We provide terrestrial and celestial reference frames including VLBI sessions until June 2022 organized by the IVS. Methods: Vienna terrestrial and celestial reference frames are computed in a common least squares adjustment of geodetic and astrometric VLBI observations with the Vienna VLBI and Satellite Software (VieVS). Results: We provide high-quality celestial and terrestrial reference frames computed from 24-hour IVS observing sessions. The CRF provides positions of 5407 radio sources. In particular, positions of sources with few observations at the time of the ICRF3 calculation could be improved. The frame also includes positions of 870 new radio sources, which are not included in ICRF3. The additional observations beyond the data used for ITRF2020 provide a more reliable estimation of positions and linear velocities of newly established VLBI Global Observing System (VGOS) telescopes., Comment: 11 pages, Submitted to the Astronomy & Astrophysics

Published
2022
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4. Parallel Statistical Model Checking for Safety Verification in Smart Grids

Author

Mancini, T., Mari, F., Melatti, I., Salvo, I., Tronci, E., Gruber, J. K., Hayes, B., Prodanovic, M., and Elmegaard, L.

Subjects
Electrical Engineering and Systems Science - Systems and Control, Computer Science - Distributed, Parallel, and Cluster Computing, 68Q60, I.6.3, J.2
Abstract

By using small computing devices deployed at user premises, Autonomous Demand Response (ADR) adapts users electricity consumption to given time-dependent electricity tariffs. This allows end-users to save on their electricity bill and Distribution System Operators to optimise (through suitable time-dependent tariffs) management of the electric grid by avoiding demand peaks. Unfortunately, even with ADR, users power consumption may deviate from the expected (minimum cost) one, e.g., because ADR devices fail to correctly forecast energy needs at user premises. As a result, the aggregated power demand may present undesirable peaks. In this paper we address such a problem by presenting methods and a software tool (APD-Analyser) implementing them, enabling Distribution System Operators to effectively verify that a given time-dependent electricity tariff achieves the desired goals even when end-users deviate from their expected behaviour. We show feasibility of the proposed approach through a realistic scenario from a medium voltage Danish distribution network., Comment: 6 pages, 1 figure. In SmartGridComm 2018. IEEE, 2018

Published
2021
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12. Youll feel better in the morning: slow wave activity and overnight mood regulation in interepisode bipolar disorder.

Author

Soehner, A, Kaplan, K, Saletin, J, Talbot, L, Hairston, I, Gruber, J, Eidelman, P, Walker, M, and Harvey, A

Subjects
Bipolar disorder, mood regulation, polysomnography, sleep, Adult, Affect, Bipolar Disorder, Brain Waves, Female, Humans, Male, Middle Aged, Polysomnography, Self-Control, Sleep Stages, Young Adult
Abstract

BACKGROUND: Sleep disturbances are prominent correlates of acute mood episodes and inadequate recovery in bipolar disorder (BD), yet the mechanistic relationship between sleep physiology and mood remains poorly understood. Using a series of pre-sleep mood inductions and overnight sleep recording, this study examined the relationship between overnight mood regulation and a marker of sleep intensity (non-rapid eye movement sleep slow wave activity; NREM SWA) during the interepisode phase of BD. METHODS: Adults with interepisode BD type 1 (BD; n = 20) and healthy adult controls (CTL; n = 23) slept in the laboratory for a screening night, a neutral mood induction night (baseline), a happy mood induction night, and a sad mood induction night. NREM SWA (0.75-4.75 Hz) was derived from overnight sleep EEG recordings. Overnight mood regulation was evaluated using an affect grid pleasantness rating post-mood induction (pre-sleep) and the next morning. RESULTS: Overnight mood regulation did not differ between groups following the sad or happy inductions. SWA did not significantly change for either group on the sad induction night compared with baseline. In BD only, SWA on the sad night was related to impaired overnight negative mood regulation. On the happy induction night, SWA increased relative to baseline in both groups, though SWA was not related to overnight mood regulation for either group. CONCLUSIONS: These findings indicate that SWA disruption may play a role in sustaining negative mood state from the previous night in interepisode BD. However, positive mood state could enhance SWA in bipolar patients and healthy adults.

Published
2018

13. Cross‐Polarization Gain Calibration of Linearly Polarized VLBI Antennas by Observations of 4C 39.25

Author

Jaron, F., primary, Martí‐Vidal, I., additional, Schartner, M., additional, González‐García, J., additional, Albentosa‐Ruiz, E., additional, Bernhart, S., additional, Böhm, J., additional, Gruber, J., additional, Modiri, S., additional, Nothnagel, A., additional, Pérez‐Díez, V., additional, Savolainen, T., additional, Soja, B., additional, Varenius, E., additional, and Xu, M. H., additional

Published
2024
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14. Cross-polarization gain calibration of linearly polarized VLBI antennas by observations of 4C 39.25

Author

Jaron, Frédéric, primary, Martí-Vidal, I, additional, Schartner, M, additional, González-García, J, additional, Albentosa-Ruiz, E, additional, Bernhart, S, additional, Böhm, J, additional, Gruber, J, additional, Modiri, S, additional, Nothnagel, A, additional, Pérez-Díez, V, additional, Savolainen, T, additional, Soja, B, additional, Varenius, E, additional, and Xu, M H, additional

Published
2024
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17. Single Molecule Spectroscopy of Monomeric LHCII: Experiment and Theory

Author

Malý, Pavel, Gruber, J. Michael, van Grondelle, Rienk, and Mančal, Tomáš

Subjects
Physics - Biological Physics, Physics - Chemical Physics
Abstract

We derive approximate equations of motion for excited state dynamics of a multilevel open quantum system weakly interacting with light to describe fluorescence detected single molecule spectra. Based on the Frenkel exciton theory, we construct a model for the chlorophyll part of the LHCII complex of higher plants and its interaction with previously proposed excitation quencher in the form of the lutein molecule Lut 1. The resulting description is valid over a broad range of timescales relevant for single molecule spectroscopy, i.e. from ps to minutes. Validity of these equations is demonstrated by comparing simulations of ensemble and single-molecule spectra of monomeric LHCII with experiments. Using a conformational change of the LHCII protein as a switching mechanism, the intensity and spectral time traces of individual LHCII complexes are simulated, and the experimental statistical distributions are reproduced. Based on our model, it is shown that with reasonable assumptions about its interaction with chlorophylls, Lut 1 can act as an efficient fluorescence quencher in LHCII., Comment: 13 pages, 5 figures and 4 pages of Supplementary Information

Published
2015

18. Ultrafast Energy Relaxation in Single Light-Harvesting Complexes

Author

Malý, Pavel, Gruber, J. Michael, Cogdell, Richard J., Mančal, Tomáš, and van Grondelle, Rienk

Subjects
Physics - Biological Physics, Physics - Chemical Physics
Abstract

Energy relaxation in light-harvesting complexes has been extensively studied by various ultrafast spectroscopic techniques, the fastest processes being in the sub-100 fs range. At the same time much slower dynamics have been observed in individual complexes by single-molecule fluorescence spectroscopy (SMS). In this work we employ a pump-probe type SMS technique to observe the ultrafast energy relaxation in single light-harvesting complexes LH2 of purple bacteria. After excitation at 800 nm, the measured relaxation time distribution of multiple complexes has a peak at 95 fs and is asymmetric, with a tail at slower relaxation times. When tuning the excitation wavelength, the distribution changes in both its shape and position. The observed behaviour agrees with what is to be expected from the LH2 excited states structure. As we show by a Redfield theory calculation of the relaxation times, the distribution shape corresponds to the expected effect of Gaussian disorder of the pigment transition energies. By repeatedly measuring few individual complexes for minutes, we find that complexes sample the relaxation time distribution on a timescale of seconds. Furthermore, by comparing the distribution from three long-lived complexes with the whole ensemble, we demonstrate that the ensemble can be considered ergodic. Our findings thus agree with the commonly used notion of an ensemble of identical LH2 complexes experiencing slow random fluctuations., Comment: 7 pages, 4 figures and 3 pages of supplementary information

Published
2015
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19. VLBI celestial and terrestrial reference frames VIE2022b

Author

Krásná, H., primary, Baldreich, L., additional, Böhm, J., additional, Böhm, S., additional, Gruber, J., additional, Hellerschmied, A., additional, Jaron, F., additional, Kern, L., additional, Mayer, D., additional, Nothnagel, A., additional, Panzenböck, O., additional, and Wolf, H., additional

Published
2023
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20. Poetische Werke

Author

J. G. Gruber, J. G. Gruber and J. G. Gruber, J. G. Gruber

Published
2021

21. Social and moral psychology of COVID-19 across 69 countries

Author

Azevedo, F, Pavlovic, T, Rego, G, Ay, F, Gjoneska, B, Etienne, T, Ross, R, Schonegger, P, Riano-Moreno, J, Cichocka, A, Capraro, V, Cian, L, Longoni, C, Chan, H, Van Bavel, J, Sjastad, H, Nezlek, J, Alfano, M, Gelfand, M, Birtel, M, Cislak, A, Lockwood, P, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomoki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, White, K, Habib, R, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Sampaio, W, Azevedo F., Pavlovic T., Rego G. G., Ay F. C., Gjoneska B., Etienne T. W., Ross R. M., Schonegger P., Riano-Moreno J. C., Cichocka A., Capraro V., Cian L., Longoni C., Chan H. F., Van Bavel J. J., Sjastad H., Nezlek J. B., Alfano M., Gelfand M. J., Birtel M. D., Cislak A., Lockwood P. L., Abts K., Agadullina E., Aruta J. J. B., Besharati S. N., Bor A., Choma B. L., Crabtree C. D., Cunningham W. A., De K., Ejaz W., Elbaek C. T., Findor A., Flichtentrei D., Franc R., Gruber J., Gualda E., Horiuchi Y., Huynh T. L. D., Ibanez A., Imran M. A., Israelashvili J., Jasko K., Kantorowicz J., Kantorowicz-Reznichenko E., Krouwel A., Laakasuo M., Lamm C., Leygue C., Lin M. -J., Mansoor M. S., Marie A., Mayiwar L., Mazepus H., McHugh C., Minda J. P., Mitkidis P., Olsson A., Otterbring T., Packer D. J., Perry A., Petersen M. B., Puthillam A., Rothmund T., Santamaria-Garcia H., Schmid P. C., Stoyanov D., Tewari S., Todosijevic B., Tsakiris M., Tung H. H., Umbres R. G., Vanags E., Vlasceanu M., Vonasch A., Yucel M., Zhang Y., Abad M., Adler E., Akrawi N., Mdarhri H. A., Amara H., Amodio D. M., Antazo B. G., Apps M., Ba M. H., Barbosa S., Bastian B., Berg A., Bernal-Zarate M. P., Bernstein M., Bialek M., Bilancini E., Bogatyreva N., Boncinelli L., Booth J. E., Borau S., Buchel O., Cameron C. D., Carvalho C. F., Celadin T., Cerami C., Chalise H. N., Cheng X., Cockcroft K., Conway J., Cordoba-Delgado M. A., Crespi C., Crouzevialle M., Cutler J., Cypryanska M., Dabrowska J., Daniels M. A., Davis V. H., Dayley P. N., Delouvee S., Denkovski O., Dezecache G., Dhaliwal N. A., Diato A. B., Di Paolo R., Drosinou M., Dulleck U., Ekmanis J., Ertan A. S., Farhana H. H., Farkhari F., Farmer H., Fenwick A., Fidanovski K., Flew T., Fraser S., Frempong R. B., Fugelsang J. A., Gale J., Garcia-Navarro E. B., Garladinne P., Ghajjou O., Gkinopoulos T., Gray K., Griffin S. M., Gronfeldt B., Gumren M., Gurung R. L., Halperin E., Harris E., Herzon V., Hruska M., Huang G., Hudecek M. F. C., Isler O., Jangard S., Jorgensen F. J., Kachanoff F., Kahn J., Dangol A. K., Keudel O., Koppel L., Koverola M., Kubin E., Kunnari A., Kutiyski Y., Laguna O. M., Leota J., Lermer E., Levy J., Levy N., Li C., Long E. U., Maglic M., McCashin D., Metcalf A. L., Miklousic I., El Mimouni S., Miura A., Molina-Paredes J., Monroy-Fonseca C., Morales-Marente E., Moreau D., Muda R., Myer A., Nash K., Nesh-Nash T., Nitschke J. P., Nurse M. S., Ohtsubo Y., de Mello V. O., O'Madagain C., Onderco M., Palacios-Galvez M. S., Palomoki J., Pan Y., Papp Z., Parnamets P., Paruzel-Czachura M., Pavlovic Z., Payan-Gomez C., Perander S., Pitman M. M., Prasad R., Pyrkosz-Pacyna J., Rathje S., Raza A., Rhee K., Robertson C. E., Rodriguez-Pascual I., Saikkonen T., Salvador-Ginez O., Santi G. C., Santiago-Tovar N., Savage D., Scheffer J. A., Schultner D. T., Schutte E. M., Scott A., Sharma M., Sharma P., Skali A., Stadelmann D., Stafford C. A., Stanojevic D., Stefaniak A., Sternisko A., Stoica A., Stoyanova K. K., Strickland B., Sundvall J., Thomas J. P., Tinghog G., Torgler B., Traast I. J., Tucciarelli R., Tyrala M., Ungson N. D., Uysal M. S., Van Lange P. A. M., van Prooijen J. -W., van Rooy D., Vastfjall D., Verkoeijen P., Vieira J. B., von Sikorski C., Walker A. C., Watermeyer J., Wetter E., Whillans A., White K., Habib R., Willardt R., Wohl M. J. A., Wojcik A. D., Wu K., Yamada Y., Yilmaz O., Yogeeswaran K., Ziemer C. -T., Zwaan R. A., Boggio P. S., Sampaio W. M., Azevedo, F, Pavlovic, T, Rego, G, Ay, F, Gjoneska, B, Etienne, T, Ross, R, Schonegger, P, Riano-Moreno, J, Cichocka, A, Capraro, V, Cian, L, Longoni, C, Chan, H, Van Bavel, J, Sjastad, H, Nezlek, J, Alfano, M, Gelfand, M, Birtel, M, Cislak, A, Lockwood, P, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomoki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, White, K, Habib, R, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Sampaio, W, Azevedo F., Pavlovic T., Rego G. G., Ay F. C., Gjoneska B., Etienne T. W., Ross R. M., Schonegger P., Riano-Moreno J. C., Cichocka A., Capraro V., Cian L., Longoni C., Chan H. F., Van Bavel J. J., Sjastad H., Nezlek J. B., Alfano M., Gelfand M. J., Birtel M. D., Cislak A., Lockwood P. L., Abts K., Agadullina E., Aruta J. J. B., Besharati S. N., Bor A., Choma B. L., Crabtree C. D., Cunningham W. A., De K., Ejaz W., Elbaek C. T., Findor A., Flichtentrei D., Franc R., Gruber J., Gualda E., Horiuchi Y., Huynh T. L. D., Ibanez A., Imran M. A., Israelashvili J., Jasko K., Kantorowicz J., Kantorowicz-Reznichenko E., Krouwel A., Laakasuo M., Lamm C., Leygue C., Lin M. -J., Mansoor M. S., Marie A., Mayiwar L., Mazepus H., McHugh C., Minda J. P., Mitkidis P., Olsson A., Otterbring T., Packer D. J., Perry A., Petersen M. B., Puthillam A., Rothmund T., Santamaria-Garcia H., Schmid P. C., Stoyanov D., Tewari S., Todosijevic B., Tsakiris M., Tung H. H., Umbres R. G., Vanags E., Vlasceanu M., Vonasch A., Yucel M., Zhang Y., Abad M., Adler E., Akrawi N., Mdarhri H. A., Amara H., Amodio D. M., Antazo B. G., Apps M., Ba M. H., Barbosa S., Bastian B., Berg A., Bernal-Zarate M. P., Bernstein M., Bialek M., Bilancini E., Bogatyreva N., Boncinelli L., Booth J. E., Borau S., Buchel O., Cameron C. D., Carvalho C. F., Celadin T., Cerami C., Chalise H. N., Cheng X., Cockcroft K., Conway J., Cordoba-Delgado M. A., Crespi C., Crouzevialle M., Cutler J., Cypryanska M., Dabrowska J., Daniels M. A., Davis V. H., Dayley P. N., Delouvee S., Denkovski O., Dezecache G., Dhaliwal N. A., Diato A. B., Di Paolo R., Drosinou M., Dulleck U., Ekmanis J., Ertan A. S., Farhana H. H., Farkhari F., Farmer H., Fenwick A., Fidanovski K., Flew T., Fraser S., Frempong R. B., Fugelsang J. A., Gale J., Garcia-Navarro E. B., Garladinne P., Ghajjou O., Gkinopoulos T., Gray K., Griffin S. M., Gronfeldt B., Gumren M., Gurung R. L., Halperin E., Harris E., Herzon V., Hruska M., Huang G., Hudecek M. F. C., Isler O., Jangard S., Jorgensen F. J., Kachanoff F., Kahn J., Dangol A. K., Keudel O., Koppel L., Koverola M., Kubin E., Kunnari A., Kutiyski Y., Laguna O. M., Leota J., Lermer E., Levy J., Levy N., Li C., Long E. U., Maglic M., McCashin D., Metcalf A. L., Miklousic I., El Mimouni S., Miura A., Molina-Paredes J., Monroy-Fonseca C., Morales-Marente E., Moreau D., Muda R., Myer A., Nash K., Nesh-Nash T., Nitschke J. P., Nurse M. S., Ohtsubo Y., de Mello V. O., O'Madagain C., Onderco M., Palacios-Galvez M. S., Palomoki J., Pan Y., Papp Z., Parnamets P., Paruzel-Czachura M., Pavlovic Z., Payan-Gomez C., Perander S., Pitman M. M., Prasad R., Pyrkosz-Pacyna J., Rathje S., Raza A., Rhee K., Robertson C. E., Rodriguez-Pascual I., Saikkonen T., Salvador-Ginez O., Santi G. C., Santiago-Tovar N., Savage D., Scheffer J. A., Schultner D. T., Schutte E. M., Scott A., Sharma M., Sharma P., Skali A., Stadelmann D., Stafford C. A., Stanojevic D., Stefaniak A., Sternisko A., Stoica A., Stoyanova K. K., Strickland B., Sundvall J., Thomas J. P., Tinghog G., Torgler B., Traast I. J., Tucciarelli R., Tyrala M., Ungson N. D., Uysal M. S., Van Lange P. A. M., van Prooijen J. -W., van Rooy D., Vastfjall D., Verkoeijen P., Vieira J. B., von Sikorski C., Walker A. C., Watermeyer J., Wetter E., Whillans A., White K., Habib R., Willardt R., Wohl M. J. A., Wojcik A. D., Wu K., Yamada Y., Yilmaz O., Yogeeswaran K., Ziemer C. -T., Zwaan R. A., Boggio P. S., and Sampaio W. M.

Abstract

The COVID-19 pandemic has affected all domains of human life, including the economic and social fabric of societies. One of the central strategies for managing public health throughout the pandemic has been through persuasive messaging and collective behaviour change. To help scholars better understand the social and moral psychology behind public health behaviour, we present a dataset comprising of 51,404 individuals from 69 countries. This dataset was collected for the International Collaboration on Social & Moral Psychology of COVID-19 project (ICSMP COVID-19). This social science survey invited participants around the world to complete a series of moral and psychological measures and public health attitudes about COVID-19 during an early phase of the COVID-19 pandemic (between April and June 2020). The survey included seven broad categories of questions: COVID-19 beliefs and compliance behaviours; identity and social attitudes; ideology; health and well-being; moral beliefs and motivation; personality traits; and demographic variables. We report both raw and cleaned data, along with all survey materials, data visualisations, and psychometric evaluations of key variables.

Published
2023

22. Hypersomnia subtypes, sleep and relapse in bipolar disorder.

Author

Kaplan, K, McGlinchey, E, Soehner, A, Gershon, A, Talbot, L, Eidelman, P, Gruber, J, and Harvey, A

Subjects
sleep, Actigraphy, Adolescent, Adult, Aged, Bipolar Disorder, Disorders of Excessive Somnolence, Factor Analysis, Statistical, Female, Humans, Male, Middle Aged, Prospective Studies, Recurrence, Sleep, Young Adult
Abstract

BACKGROUND: Though poorly defined, hypersomnia is associated with negative health outcomes and new-onset and recurrence of psychiatric illness. Lack of definition impedes generalizability across studies. The present research clarifies hypersomnia diagnoses in bipolar disorder by exploring possible subgroups and their relationship to prospective sleep data and relapse into mood episodes. METHOD: A community sample of 159 adults (aged 18-70 years) with bipolar spectrum diagnoses, euthymic at study entry, was included. Self-report inventories and clinician-administered interviews determined features of hypersomnia. Participants completed sleep diaries and wore wrist actigraphs at home to obtain prospective sleep data. Approximately 7 months later, psychiatric status was reassessed. Factor analysis and latent profile analysis explored empirical groupings within hypersomnia diagnoses. RESULTS: Factor analyses confirmed two separate subtypes of hypersomnia (long sleep and excessive sleepiness) that were uncorrelated. Latent profile analyses suggested a four-class solution, with long sleep and excessive sleepiness again representing two separate classes. Prospective sleep data suggested that the sleep of long sleepers is characterized by a long time in bed, not long sleep duration. Longitudinal assessment suggested that excessive sleepiness at baseline predicted mania/hypomania relapse. CONCLUSIONS: This study is the largest of hypersomnia to include objective sleep measurement, and refines our understanding of classification, characterization and associated morbidity. Hypersomnia appears to be comprised of two separate subgroups: long sleep and excessive sleepiness. Long sleep is characterized primarily by long bedrest duration. Excessive sleepiness is not associated with longer sleep or bedrest, but predicts relapse to mania/hypomania. Understanding these entities has important research and treatment implications.

Published
2015

23. An evaluation of the FDA’s analysis of the costs and benefits of the graphic warning label regulation

Author

Max, Wendy, Chaloupka, FJ, Warner, KE, Acemoğlu, D, Gruber, J, Laux, F, Newhouse, J, Schelling, T, and Sindelar, J

Abstract

© 2015, BMJ Publishing Group. All rights reserved.The Family Smoking Prevention and Tobacco Control Act of 2009 gave the Food and Drug Administration (FDA) regulatory authority over cigarettes and smokeless tobacco products and authorised it to assert juri

Published
2015

28. A Stepped Wedge, Cluster-Randomized Trial of a Household UV-Disinfection and Safe Storage Drinking Water Intervention in Rural Baja California Sur, Mexico

Author

Gruber, J. S, Reygadas, F., Arnold, B. F, Ray, I., Nelson, K., and Colford, J. M

Subjects
BRII recipient: Colford (hybrid)
Abstract

In collaboration with a local non-profit organization, this study evaluated the expansion of a program that promoted and installed Mesita Azul, an ultraviolet-disinfection system designed to treat household drinking water in rural Mexico. We conducted a 15-month, cluster-randomized stepped wedge trial by randomizing the order in which 24 communities (444 households) received the intervention. We measured primary outcomes (water contamination and diarrhea) during seven household visits. The intervention increased the percentage of households with access to treated and safely stored drinking water (23–62%), and reduced the percentage of households with Escherichia coli contaminated drinking water (risk difference (RD): −19% [95% CI: −27%, −14%]). No significant reduction in diarrhea was observed (RD: −0.1% [95% CI: −1.1%, 0.9%]). We conclude that household water quality improvements measured in this study justify future promotion of the Mesita Azul, and that future studies to measure its health impact would be valuable if conducted in populations with higher diarrhea prevalence.

Published
2013

33. National identity predicts public health support during a global pandemic

Author

Van Bavel, J, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, J, Pavlovic, T, Alfano, M, Gelfand, M, Azevedo, F, Birtel, M, Cislak, A, Lockwood, P, Ross, R, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Riano-Moreno, J, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ay, F, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Etienne, T, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Longoni, C, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, Oldemburgo de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, G, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, W, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schonegger, P, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Van Bavel J. J., Cichocka A., Capraro V., Sjastad H., Nezlek J. B., Pavlovic T., Alfano M., Gelfand M. J., Azevedo F., Birtel M. D., Cislak A., Lockwood P. L., Ross R. M., Abts K., Agadullina E., Aruta J. J. B., Besharati S. N., Bor A., Choma B. L., Crabtree C. D., Cunningham W. A., De K., Ejaz W., Elbaek C. T., Findor A., Flichtentrei D., Franc R., Gjoneska B., Gruber J., Gualda E., Horiuchi Y., Huynh T. L. D., Ibanez A., Imran M. A., Israelashvili J., Jasko K., Kantorowicz J., Kantorowicz-Reznichenko E., Krouwel A., Laakasuo M., Lamm C., Leygue C., Lin M. -J., Mansoor M. S., Marie A., Mayiwar L., Mazepus H., McHugh C., Minda J. P., Mitkidis P., Olsson A., Otterbring T., Packer D. J., Perry A., Petersen M. B., Puthillam A., Riano-Moreno J. C., Rothmund T., Santamaria-Garcia H., Schmid P. C., Stoyanov D., Tewari S., Todosijevic B., Tsakiris M., Tung H. H., Umbres R. G., Vanags E., Vlasceanu M., Vonasch A., Yucel M., Zhang Y., Abad M., Adler E., Akrawi N., Mdarhri H. A., Amara H., Amodio D. M., Antazo B. G., Apps M., Ay F. C., Ba M. H., Barbosa S., Bastian B., Berg A., Bernal-Zarate M. P., Bernstein M., Bialek M., Bilancini E., Bogatyreva N., Boncinelli L., Booth J. E., Borau S., Buchel O., Cameron C. D., Carvalho C. F., Celadin T., Cerami C., Chalise H. N., Cheng X., Cian L., Cockcroft K., Conway J., Cordoba-Delgado M. A., Crespi C., Crouzevialle M., Cutler J., Cypryanska M., Dabrowska J., Daniels M. A., Davis V. H., Dayley P. N., Delouvee S., Denkovski O., Dezecache G., Dhaliwal N. A., Diato A. B., Di Paolo R., Drosinou M., Dulleck U., Ekmanis J., Ertan A. S., Etienne T. W., Farhana H. H., Farkhari F., Farmer H., Fenwick A., Fidanovski K., Flew T., Fraser S., Frempong R. B., Fugelsang J. A., Gale J., Garcia-Navarro E. B., Garladinne P., Ghajjou O., Gkinopoulos T., Gray K., Griffin S. M., Gronfeldt B., Gumren M., Gurung R. L., Halperin E., Harris E., Herzon V., Hruska M., Huang G., Hudecek M. F. C., Isler O., Jangard S., Jorgensen F. J., Kachanoff F., Kahn J., Dangol A. K., Keudel O., Koppel L., Koverola M., Kubin E., Kunnari A., Kutiyski Y., Laguna O., Leota J., Lermer E., Levy J., Levy N., Li C., Long E. U., Longoni C., Maglic M., McCashin D., Metcalf A. L., Miklousic I., El Mimouni S., Miura A., Molina-Paredes J., Monroy-Fonseca C., Morales-Marente E., Moreau D., Muda R., Myer A., Nash K., Nesh-Nash T., Nitschke J. P., Nurse M. S., Ohtsubo Y., Oldemburgo de Mello V., O'Madagain C., Onderco M., Palacios-Galvez M. S., Palomaki J., Pan Y., Papp Z., Parnamets P., Paruzel-Czachura M., Pavlovic Z., Payan-Gomez C., Perander S., Pitman M. M., Prasad R., Pyrkosz-Pacyna J., Rathje S., Raza A., Rego G. G., Rhee K., Robertson C. E., Rodriguez-Pascual I., Saikkonen T., Salvador-Ginez O., Sampaio W. M., Santi G. C., Santiago-Tovar N., Savage D., Scheffer J. A., Schonegger P., Schultner D. T., Schutte E. M., Scott A., Sharma M., Sharma P., Skali A., Stadelmann D., Stafford C. A., Stanojevic D., Stefaniak A., Sternisko A., Stoica A., Stoyanova K. K., Strickland B., Sundvall J., Thomas J. P., Tinghog G., Torgler B., Traast I. J., Tucciarelli R., Tyrala M., Ungson N. D., Uysal M. S., Van Lange P. A. M., van Prooijen J. -W., van Rooy D., Vastfjall D., Verkoeijen P., Vieira J. B., von Sikorski C., Walker A. C., Watermeyer J., Wetter E., Whillans A., Willardt R., Wohl M. J. A., Wojcik A. D., Wu K., Yamada Y., Yilmaz O., Yogeeswaran K., Ziemer C. -T., Zwaan R. A., Boggio P. S., Van Bavel, J, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, J, Pavlovic, T, Alfano, M, Gelfand, M, Azevedo, F, Birtel, M, Cislak, A, Lockwood, P, Ross, R, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Riano-Moreno, J, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ay, F, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Etienne, T, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Longoni, C, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, Oldemburgo de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, G, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, W, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schonegger, P, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, Boggio, P, Van Bavel J. J., Cichocka A., Capraro V., Sjastad H., Nezlek J. B., Pavlovic T., Alfano M., Gelfand M. J., Azevedo F., Birtel M. D., Cislak A., Lockwood P. L., Ross R. M., Abts K., Agadullina E., Aruta J. J. B., Besharati S. N., Bor A., Choma B. L., Crabtree C. D., Cunningham W. A., De K., Ejaz W., Elbaek C. T., Findor A., Flichtentrei D., Franc R., Gjoneska B., Gruber J., Gualda E., Horiuchi Y., Huynh T. L. D., Ibanez A., Imran M. A., Israelashvili J., Jasko K., Kantorowicz J., Kantorowicz-Reznichenko E., Krouwel A., Laakasuo M., Lamm C., Leygue C., Lin M. -J., Mansoor M. S., Marie A., Mayiwar L., Mazepus H., McHugh C., Minda J. P., Mitkidis P., Olsson A., Otterbring T., Packer D. J., Perry A., Petersen M. B., Puthillam A., Riano-Moreno J. C., Rothmund T., Santamaria-Garcia H., Schmid P. C., Stoyanov D., Tewari S., Todosijevic B., Tsakiris M., Tung H. H., Umbres R. G., Vanags E., Vlasceanu M., Vonasch A., Yucel M., Zhang Y., Abad M., Adler E., Akrawi N., Mdarhri H. A., Amara H., Amodio D. M., Antazo B. G., Apps M., Ay F. C., Ba M. H., Barbosa S., Bastian B., Berg A., Bernal-Zarate M. P., Bernstein M., Bialek M., Bilancini E., Bogatyreva N., Boncinelli L., Booth J. E., Borau S., Buchel O., Cameron C. D., Carvalho C. F., Celadin T., Cerami C., Chalise H. N., Cheng X., Cian L., Cockcroft K., Conway J., Cordoba-Delgado M. A., Crespi C., Crouzevialle M., Cutler J., Cypryanska M., Dabrowska J., Daniels M. A., Davis V. H., Dayley P. N., Delouvee S., Denkovski O., Dezecache G., Dhaliwal N. A., Diato A. B., Di Paolo R., Drosinou M., Dulleck U., Ekmanis J., Ertan A. S., Etienne T. W., Farhana H. H., Farkhari F., Farmer H., Fenwick A., Fidanovski K., Flew T., Fraser S., Frempong R. B., Fugelsang J. A., Gale J., Garcia-Navarro E. B., Garladinne P., Ghajjou O., Gkinopoulos T., Gray K., Griffin S. M., Gronfeldt B., Gumren M., Gurung R. L., Halperin E., Harris E., Herzon V., Hruska M., Huang G., Hudecek M. F. C., Isler O., Jangard S., Jorgensen F. J., Kachanoff F., Kahn J., Dangol A. K., Keudel O., Koppel L., Koverola M., Kubin E., Kunnari A., Kutiyski Y., Laguna O., Leota J., Lermer E., Levy J., Levy N., Li C., Long E. U., Longoni C., Maglic M., McCashin D., Metcalf A. L., Miklousic I., El Mimouni S., Miura A., Molina-Paredes J., Monroy-Fonseca C., Morales-Marente E., Moreau D., Muda R., Myer A., Nash K., Nesh-Nash T., Nitschke J. P., Nurse M. S., Ohtsubo Y., Oldemburgo de Mello V., O'Madagain C., Onderco M., Palacios-Galvez M. S., Palomaki J., Pan Y., Papp Z., Parnamets P., Paruzel-Czachura M., Pavlovic Z., Payan-Gomez C., Perander S., Pitman M. M., Prasad R., Pyrkosz-Pacyna J., Rathje S., Raza A., Rego G. G., Rhee K., Robertson C. E., Rodriguez-Pascual I., Saikkonen T., Salvador-Ginez O., Sampaio W. M., Santi G. C., Santiago-Tovar N., Savage D., Scheffer J. A., Schonegger P., Schultner D. T., Schutte E. M., Scott A., Sharma M., Sharma P., Skali A., Stadelmann D., Stafford C. A., Stanojevic D., Stefaniak A., Sternisko A., Stoica A., Stoyanova K. K., Strickland B., Sundvall J., Thomas J. P., Tinghog G., Torgler B., Traast I. J., Tucciarelli R., Tyrala M., Ungson N. D., Uysal M. S., Van Lange P. A. M., van Prooijen J. -W., van Rooy D., Vastfjall D., Verkoeijen P., Vieira J. B., von Sikorski C., Walker A. C., Watermeyer J., Wetter E., Whillans A., Willardt R., Wohl M. J. A., Wojcik A. D., Wu K., Yamada Y., Yilmaz O., Yogeeswaran K., Ziemer C. -T., Zwaan R. A., and Boggio P. S.

Abstract

Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.

Published
2022

43. Current Status of the EU-VGOS Project

Author

Albentosa, E., Alef, W., Bernhart, S., Böhm, J., González, R., Choi, Y., Gansmoe, T., Espada, S., Miró, C., Girdiuk, A., González García, J., Wennesland, S., Gruber, J., Haas, R., Hammargren, R., Heinkelmann, R., Jaron, F., Kareinen, N., Kirkvik, A., Krásná, H., Martinez, E., Martí-Vidal, I., Meldahl, A., Melnikov, A., Modiri, S., Neidhardt, A., Nothnagel, A., Panzenböck, O., Pérez, V., Petrov, L., Plötz, C., Rottmann, H., Savolainen, T., Schartner, M., Schüler, T., Schuh, H., Soja, B., Varenius, E., de Vicente, P., Wagner, J., Xu, M., Zubko, N., Kettenis, M., Matsumoto, S., Porcas, R., Small, D., and Verkouter, M.

Published
2023

44. Risk factors associated with 10% weight change in treatment-naïve and treatment-experienced people living with HIV initiating or switching to an NNRTI- or INSTI-based antiretroviral therapy in four large cohort studies

Author

Robineau, O, Marongiu, A, Stellbrink, H-J, Meynard, JL, Brunetta, J, Turner, D, D’Arminio Monforte, A, Ángel Castaño-Carracedo, M, Van Welzen, B, Williams, L, Haubrich, R, Heinzkill, M, Sahali, S, Schreiber, S, Gruber, J, Cohen, C, and Esser, S

Abstract

Background: Pooled analyses of randomised controlled trials have shown weight gain (WG) following initiation/switching of antiretroviral therapy (ART) in people living with HIV (PLWHIV) [1,2]. We explored risk factors associated with ≥10% WG/weight loss (WL) in PLWHIV after initiating/switching ART. Materials and methods: Weight data were analysed from treatment-experienced (TE) and treatment-naïve (TN) PLWHIV enrolled in four Gilead-sponsored, post-authorisation, observational HIV cohort studies (2010 to 2020) and who initiated/switched non-nucleoside reverse transcriptase inhibitor (NNRTI)– or integrase strand transfer inhibitor (INSTI)–based ART. Participants had weight data available at baseline and 10 to 15 months post-baseline. Adjusted odds ratios (ORs) for potential risk factors for ≥10% WG/WL at 12 months in participants were estimated using multivariable logistic regression. Results: Two thousand, six hundred and sixty-six participants were included. Median age: 38 (TN)/47 years (TE). Of TE participants, 914/1939 (47%) switched from emtricitabine (F)/tenofovir disoproxil fumarate (TDF) backbone to F/tenofovir alafenamide (TAF), and 162/1939 (8%) from abacavir (ABC)/lamivudine (3TC) to F/TAF. Two hundred and twenty-nine of 727 (31%) TN participants had ≥10% WG (Table 1). Risk factors for ≥10% WG were F/TAF backbone (vs F/TDF; p < 0.001), low baseline CD4 (vs higher; p = 0.010), and being underweight (vs normal; p= 0.024; Figure 1). Eight of 727 (1%) TN participants had ≥10% WL. No significant risk factors for ≥10% WL were identified. Four hundred and fifty-one of 1939 (23%) TE participants had ≥10% WG (Table 1). Risk factors for ≥10% WG were INSTI-based ART (vs NNRTI; p = 0.029), F/TAF backbone (vs F/TDF; p < 0.001), being female (vs male; p = 0.002), switching from F/TDF to F/TAF (vs no switch; p = 0.001), being underweight (vs normal; p < 0.001), and having comorbidities associated with obesity (vs not; p = 0.046). Forty of 1939 (2%) TE participants had ≥10% WL. Only comedications associated with WL were predictors for ≥10% WL (OR 2.73 [95% CI 1.02 to 7.31]; p = 0.046). Conclusions: After initiating ART, WG was associated with F/TAF backbone, low baseline CD4 count, and being underweight in TN participants. In TE participants, WG was associated with INSTI-based ART, F/TAF backbone, switching from F/TDF to F/TAF, being female, and being underweight at baseline. Findings are consistent with the documented WG suppressive effect of F/TDF [3-6]. These data cannot determine the contribution of F/TAF to WG beyond the absence of the F/TDF WG suppressive effect. References: 1. Sax PE, Erlandson KM, Lake JE, Mccomsey GA, Orkin C, Esser S, et al. Weight gain following initiation of antiretroviral therapy: risk factors in randomized comparative clinical trials. Clin Infect Dis. 2020;71:1379-89. 2. Erlandson KM, Carter CC, Melbourne K, Brown TT, Cohen C, Das M, et al. Weight change following antiretroviral therapy switch in people with viral suppression: pooled data from randomized clinical trials. Clin Infect Dis. 2021;73:1440-51. 3. Glidden DV, Mulligan K, McMahan V, Anderson PL, Guanira J, Chariyalertsak S, et al. Metabolic effects of preexposure prophylaxis with coformulated tenofovir disoproxil fumarate and emtricitabine. Clin Infect Dis. 2018;67:411-9. 4. Ogbuagu O, Ruane PJ, Podzamczer D, Salazar LC, Henry K, Asmuth DM, et al. Long-term safety and efficacy of emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV-1 pre-exposure prophylaxis: week 96 results from a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet HIV. 2021;8:e397-e407. 5. Landovitz RJ, Donnell D, Clement M, Hanscom B, Cottle L, Coelho L, et al. HPTN 083 final results: Pre-exposure prophylaxis containing long-acting injectable cabotegravir is safe and highly effective for cisgender men and transgender women who have sex with men. 23rd International AIDS Conference; 2020 Jul 6-10. Oral OAXLB01. 6. Shah S, Pilkington V, Hill A. Use of tenofovir disoproxil fumarate shows weight loss vs placebo: a meta-analysis of 7 clinical trials in 19,359 HIV-negative individuals. IDWeek 2021; 2021 Sep 29-Oct 3; virtual. Poster P882.

Published
2022

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