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236 results on '"Grunz, Horst"'

3. Xenopus X-box binding protein 1, a leucine zipper transcription factor, is involved in the BMP signaling pathway

Author

Zhao, Hui, Cao, Ying, and Grunz, Horst

Subjects
Genetic transcription -- Research, Leucine -- Research, Xenopus -- Genetic aspects, Xenopus -- Research, Biological sciences
Abstract

We describe a novel basic leucine zipper transcription factor, XXBP-1, which interacts with BMP-4 in a positive feedback loop. It is a maternal factor and is zygotically expressed in the dorsal blastopore lip and ventral ectoderm with the exception of the prospective neural plate during gastrulation. Overexpression of XXBP-1 leads to ventralization of early embryos as described for BMP-4, and inhibits neuralization of dissociated ectoderm. Consistent with mediating BMP signaling, we show that the ectopic expression of XXBP-1 recovers the expression of epidermal keratin and reverses the dorsalization imposed by truncated BMP receptor type I, indicating that it may act downstream of the BMP receptor. Its effects can be partially mimicked by a fusion construct containing the VP16 activator domain and the XXBP-1 DNA-binding domain. In contrast, fusing the DNA-binding domain to the even-skipped repressor domain leads to upregulation of the neural markers NCAM and nrp-1 in animal cap assay. Taken together, the results suggest a role for XXBP-1 in the control of neural differentiation, possibly as an activator. Keywords: XXBP-1; bZIP; BMP-4; Fusion protein; Spemann-Mangold organizer; Pattern formation

Published
2003

6. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals

Author

Piccolo, Stefano, Agius, Eric, Leyns, Luc, Bhattacharyya, Subha, Grunz, Horst, Bouwmeester Tewis, and De Rbertis, E.M.

Subjects
Messenger RNA -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The vertebrate head is believed to be induced by different signals from those organizing trunk-tail development. The cerberus gene encodes a protein expressed in anterior endoderm which is able to induce ectopic heads in the absence of truck structures. The cerberus protein acts as a multivalent growth-factor antagonist, binding to Nodel, BMP and Wnt proteins through independent sites.

Published
1999

16. Contributors

Author

Bennardo, Francesco, Chow, Ming Fai, Engels, Jan Frederick, Goodsell, David S., Halpern, Georges M., Kayser, Oliver, Ullrich, Oliver, Bernhardt, Rita, Bornscheuer, Uwe, Cautherley, George, Chakrabarty, Ananda, Charpentier, Emmanuelle, Chow, King, Clark, David P., Demain, Arnold L., Dingermann, Theodor, Dübel, Stefan, Friedrich, Roland, Fromherz, Peter, Fuchs, Dietmar, Fukui, Saburo, Gänßler, Karla, Ghisalba, Oreste, Grunz, Horst, Halpern, Georges, Hempel, Albrecht, Hew, Choy-L., Hillenkamp, Franz, Hock, Bertold, Holtzhauer, Martin, Huntoon, Jon, Kempken, Frank, Kiderlen, Albrecht F., Klenz, Uwe, Law, Louiza, Lewen-Dörr, Inca, Lim, Hwa A., Ludwig-Müller, Jutta, Martin, Stephan, Matter, Alex, Meyer, Wolfgang, van Montagu, Marc, Müller-Esterl, Werner, Niessner, Reinhard, Pauly, Susanne, Polle, Jürgen, Rapoport, Tom A., Reuss, Matthias, Reski, Ralf, Sahm, Hermann, Scheller, Frieder W., Schmidt, Steffen, Schulz, Olaf, Sprenger, Georg, Stewart, Eric, Strobel, Gary, Stüber, Kurt, Tanaka, Atsuo, Trau, Dieter, Tuschl, Thomas, Wadsworth, Larry, Wan, Terence S.M., Wang, Zeng-yu, Wellmann, Eckhard, Wink, Michael, Wolf, Dieter, Zastrow, Leonhard, Aehle, Wolfgang, Arber, Werner, Barnum, Susan R., Beier, Hildburg, Ian, Billings, John, Chakrabarty, Ananda M., Chan, Cangel Pui Yee, Coutelle, Charles, Diamond, Jared M., Djerassi, Carl, Endo, Akira, Feldmeier, Herrmann, Fischer, Ernst Peter, Gänzle, Michael, Geißler, Erhard, Greenfield, Susan A., Guttmacher, Alan E., Haass, Christian, Hatzak, Frank, Jeffreys, Sir Alec, Kekulé, Alexander, Kinoshita, Shukuo, Korsman, Stephen, Larrick, James W., Ligler, Frances S., MacDiarmid, Alan, Paquet, Dominik, Perlitz, Uwe, Potrykus, Ingo, Preiser, Wolfgang, Rainer, Timothy H., Reich, Jens, Richardson, Michael K., Rokem, Stefan, Rossbach, Michael, Sankula, Sujatha, Schatz, Gottfried, Spelsberg, Gerd, Strobel, Gary A., Tautz, Jurgen, Wandrey, Christian, Wei, Fuwen, Whiteson, Katrine, Wilmut, Ian, Winterhalter, Christoph, Wolf, Eckhard, Woodruff, Boyd, Yang, Daichang, and Zinke, Holger

Published
2023
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39. Neural induction in embryos

Author

Tiedemann, Heinz, primary, Asashima, Makoto, additional, Grunz, Horst, additional, Knochel, Walter, additional, and Tiedemann, Hildegard, additional

Published
1998
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49. Contributors

Author

Bennardo, Francesco, Chow, Ming Fai, Engels, Jan Frederick, Goodsell, David S., Kayser, Oliver, Ullrich, Oliver, Bernhardt, Rita, Bornscheuer, Uwe, Cautherley, George, Chakrabarty, Ananda, Charpentier, Emmanuelle, Chow, King, Clark, David P., Demain, Arnold L., Dingermann, Theodor, Dübel, Stefan, Friedrich, Roland, Fromherz, Peter, Fuchs, Dietmar, Fukui, Saburo, Gänßler, Karla, Ghisalba, Oreste, Grunz, Horst, Halpern, Georges, Hempel, Albrecht, Hew, Choy-L., Hillenkamp, Franz, Hock, Bertold, Holtzhauer, Martin, Huntoon, Jon, Kempken, Frank, Kiderlen, Albrecht F., Klenz, Uwe, Law, Louiza, Lewen-Dörr, Inca, Lim, Hwa A., Ludwig-Müller, Jutta, Martin, Stephan, Matter, Alex, Meyer, Wolfgang, van Montagu, Marc, Müller-Esterl, Werner, Niessner, Reinhard, Pauly, Susanne, Polle, Jürgen, Rapoport, Tom A., Reuss, Matthias, Sahm, Hermann, Scheller, Frieder W., Schmidt, Steffen, Schulz, Olaf, Sprenger, Georg, Stewart, Eric, Strobel, Gary, Stüber, Kurt, Tanaka, Atsuo, Trau, Dieter, Tuschl, Thomas, Wadsworth, Larry, Wan, Terence S.M., Wang, Zeng-yu, Wellmann, Eckhard, Wink, Michael, Wolf, Dieter, Zastrow, Leonhard, Aehle, Wolfgang, Arber, Werner, Barnum, Susan R., Beier, Hildburg, Ian, Billings, John, Chakrabarty, Ananda M., Chan, Cangel Pui Yee, Coutelle, Charles, Djerassi, Carl, Endo, Akira, Feldmeier, Herrmann, Fischer, Ernst Peter, Gänzle, Michael, Geißler, Erhard, Greenfield, Susan A., Guttmacher, Alan E., Haass, Christian, Hatzak, Frank, Jeffreys, Sir Alec, Kekulé, Alexander, Kinoshita, Shukuo, Korsman, Stephen, Larrick, James W., Ligler, Frances S., MacDiarmid, Alan, Paquet, Dominik, Perlitz, Uwe, Potrykus, Ingo, Preiser, Wolfgang, Rainer, Timothy H., Reich, Jens, Richardson, Michael K., Rokem, Stefan, Rossbach, Michael, Sankula, Sujatha, Schatz, Gottfried, Spelsberg, Gerd, Strobel, Gary A., Tautz, Jurgen, Wandrey, Christian, Wei, Fuwen, Whiteson, Katrine, Wilmut, Ian, Winterhalter, Christoph, Wolf, Eckhard, Woodruff, Boyd, Yang, Daichang, and Zinke, Holger

Published
2017
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50. Electron microscope study of the binding of Con A-gold to superficial and inner ectoderm layers of Xenopus laevis and its relation to the neural-inducing activity of this lectin.

Author

Tacke, Lothar and Grunz, Horst

Abstract

Isolated competent amphibian ectoderm differentiates into neural (archencephalic) structures when treated with the plant lectin concanavalin A (Con A). While the inner ectoderm layer of Xenopus laevis forms brain structures after incubation with Con A, the outer ectoderm layer differentiates into ciliated epidermis only. This difference can be correlated with the pattern of Con A bound to the plasma membrane. With gold-labelled Con A it could be shown by transmission electron microscopy (TEM) that the outer ectoderm binds substantially less lectin than the inner layer. Furthermore we observed characteristic differences at the apical and basal surfaces of the cells of the same layer, i.e. on the apical cell surface of the superficial layer almost no Con A-gold could be found. In contrast, we observed a lot of gold particles on the basal cell side of the superficial layer. However, the number on both surfaces (apical and basal side of the cell) of the inner ectoderm layer was essentially higher, which could explain its biological reaction to the Con A stimulus and the differentiation into neural structures. The data presented in this paper indicate that early and late gastrula ectoderm bind similar amounts of Con A and support the view that the decrease in competence is not correlated with a loss of receptors for inducing factors. Furthermore, we describe the binding and the internalization of Con A via receptor-mediated endocytosis and the further fate of the Con A-gold-receptor complex inside the target cell. [ABSTRACT FROM AUTHOR]

Published
1986
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