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14 results on '"Gsponer, Joel R."'

7. Indication for Active Surveillance in the Era of MRI-Targeted Prostate Biopsies.

Author

Wetterauer, Christian, Federer-Gsponer, Joel R., Leboutte, Francois D.J.P., Mona, Robin, Ebbing, Jan, Rentsch, Cyrill A., Manka, Lukas, Seifert, Hans H., Wyler, Stephen, Recker, Franz, and Kwiatkowski, Maciej

Subjects
*PROSTATE biopsy, *WATCHFUL waiting, *PROSTATE cancer
Abstract

Introduction: Active surveillance (AS) strategies were established to avoid overtreatment of low-risk prostate cancer (PCa) patients. Low tumor volume represents one indication criteria; however, applying this criterion after MRI-targeted prostate biopsies may lead to overestimation of tumor volume; wherefore, patients suitable for AS would be exposed to the risk of overtreatment. Methods: This retrospective analysis included 318 patients in which PCa was detected by MRI-TRUS fusion prostate biopsy. Classic and extended indication for AS included Gleason 6 and Gleason 3 + 4 cancer, respectively. We assessed the effect of targeted biopsies and temporary rating strategies on eligibility for AS and developed new "composite" algorithms to more accurately assess eligibility for AS. Results: Forty-four (13.8%) and 60 (18.9%) of the 318 patients qualified for AS according to "classic" and "extended" criteria, respectively. Application of the "composite 1" definition led to AS eligibility of 52 of 248 patients (20.97%) in the classic and of 77 of 248 patients (31.05%) in the "extended" group. Conclusions: We could demonstrate that classic algorithms led to ineligibility of patients for AS. We propose a new rating algorithm to improve tumor assessment for a more accurate indication for AS. [ABSTRACT FROM AUTHOR]

Published
2022
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8. Novices in MRI-targeted prostate biopsy benefit from structured reporting of MRI findings

Author

Wetterauer, Christian, primary, Winkel, David Jean, additional, Federer-Gsponer, Joel R., additional, Leboutte, Francois, additional, Horn, Tobias, additional, Schnyder, Petra, additional, Dugas, Sarah G., additional, Zahiti, Leutrim, additional, Engesser, Christian, additional, Halla, Armin, additional, Seifert, Hans-Helge, additional, Boll, Daniel T., additional, and Ebbing, Jan, additional

Published
2019
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9. Early development of human lymphomas in a prostate cancer xenograft program using triple knock-out immunocompromised mice

Author

Püschel, Heike, Vlajnic, Tatjana, Cecchini, Marco Giovanni, Rentsch, Cyrill Achim, Wetterauer, Christian, Ruiz, Christian, Schüler, Julia, Bachmann, Alexander, Bubendorf, Lukas, Gsponer, Joel R, Thalmann, George, Zellweger, Tobias, Dirnhofer, Stephan, and Schneider, Julia

Subjects
610 Medicine & health
Abstract

BACKGROUND There is an urgent need for preclinical models of prostate cancer; however, clinically relevant patient-derived prostate cancer xenografts (PDXs) are demanding to establish. METHODS Sixty-seven patients who were undergoing palliative transurethral surgery or radical prostatectomy for histologically confirmed, clinically relevant prostate cancer were included in the study. Fresh prostate cancer tissue was identified by frozen analysis in 48 patients. The cancer tissue was transplanted subcutaneously and under the renal capsule of NSG and NOG mice supplemented with human testosterone. All growing PDXs were evaluated by histology and immunohistochemistry. RESULTS Early assessment of the animals at least three months after transplantation included 27/48 (56.3%) eligible PDX cohorts. PDX growth was detected in 10/27 (37%) mouse cohorts. Eight of the ten PDXs were identified as human donor derived lymphomas, including seven Epstein Barr virus (EBV)-positive diffuse large B-cell lymphomas and one EBV-negative peripheral T-cell lymphoma. One sample consisted of benign prostatic tissue, and one sample comprised a benign epithelial cyst. Prostate cancer was not detected in any of the samples. CONCLUSIONS Tumors that arise within the first three months after prostate cancer xenografting may represent patient-derived EBV-positive lymphomas in up to 80% of the early growing PDXs when using triple knockout NSG immunocompromised mice. Therefore, lymphoma should be excluded in prostate cancer xenografts that do not resemble typical prostatic adenocarcinoma. Prostate 9999: XX-XX, 2014. © 2015 Wiley Periodicals, Inc.

Published
2015
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12. Estrogen receptor β expression and androgen receptor phosphorylation correlate with a poor clinical outcome in hormone-naïve prostate cancer and are elevated in castration-resistant disease

Author

Zellweger, Tobias, primary, Stürm, Susanne, additional, Rey, Silvia, additional, Zlobec, Inti, additional, Gsponer, Joel R, additional, Rentsch, Cyrill A, additional, Terracciano, Luigi M, additional, Bachmann, Alexander, additional, Bubendorf, Lukas, additional, and Ruiz, Christian, additional

Published
2013
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13. Deep Clonal Profiling of Formalin Fixed Paraffin Embedded Clinical Samples

Author

Holley, Tara, primary, Lenkiewicz, Elizabeth, additional, Evers, Lisa, additional, Tembe, Waibhav, additional, Ruiz, Christian, additional, Gsponer, Joel R., additional, Rentsch, Cyrill A., additional, Bubendorf, Lukas, additional, Stapleton, Mark, additional, Amorese, Doug, additional, Legendre, Christophe, additional, Cunliffe, Heather E., additional, McCullough, Ann E., additional, Pockaj, Barbara, additional, Craig, David, additional, Carpten, John, additional, Von Hoff, Daniel, additional, Iacobuzio-Donahue, Christine, additional, and Barrett, Michael T., additional

Published
2012
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14. Preexisting BCG-Specific T Cells Improve Intravesical Immunotherapy for Bladder Cancer

Author

Biot, Claire, primary, Rentsch, Cyrill A., additional, Gsponer, Joel R., additional, Birkhäuser, Frédéric D., additional, Jusforgues-Saklani, Hélène, additional, Lemaître, Fabrice, additional, Auriau, Charlotte, additional, Bachmann, Alexander, additional, Bousso, Philippe, additional, Demangel, Caroline, additional, Peduto, Lucie, additional, Thalmann, George N., additional, and Albert, Matthew L., additional

Published
2012
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