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107 results on '"Gu, Li ‐ Juan"'

19. Distributed optical fiber acoustic sensor for in situmonitoring of marine natural gas hydrates production for the first time in the Shenhu Area, China

Author

He, Xiang-ge, Wu, Xue-min, Wang, Lei, Liang, Qian-yong, Gu, Li-juan, Liu, Fei, Lu, Hai-long, Zhang, Yi, and Zhang, Min

Abstract

The distributed acoustic sensor (DAS) uses a single optical cable as the sensing unit, which can capture the acoustic and vibration signals along the optical cable in real-time. So it is suitable for monitoring downhole production activities in the process of oil and gas development. The authors applied the DAS system in a gas production well in the South China Sea for in situmonitoring of the whole wellbore for the first time and obtained the distributed acoustic signals along the whole wellbore. These signals can clearly distinguish the vertical section, curve section, and horizontal production section. The collected acoustic signal with the frequency of approximately 50 Hz caused by the electric submersible pump exhibit a signal-to-noise ratio higher than 27 dB. By analyzing the acoustic signals in the production section, it can be located the layers with high gas production rates. Once an accurate physical model is built in the future, the gas production profile will be obtained. In addition, the DAS system can track the trajectory of downhole tools in the wellbore to guide the operation. Through the velocity analysis of the typical signals, the type of fluids in the wellbore can be distinguished. The successful application of the system provides a promising whole wellbore acoustic monitoring tool for the production of marine gas hydrate, with a good application prospect.

Published
2022
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20. Perspectives of Alopecia behind the Regulation of Foxn1 Gene Exposes the Human Nude Phenotype

Author

Begum, Shahnaz, Hossain, Md Jamil, Gu, Li Juan, Sung, Chang Keun, Begum, Shahnaz, Hossain, Md Jamil, Gu, Li Juan, and Sung, Chang Keun

Abstract

The hair follicle (HF) is remarkable for its dynamic structure and one of the most prominent mini organs of the skin. The most visible end product formed by the hair follicle known as “hair shaft”- a tissue with a highly keratinized protein. Therefore, alopecia or baldness issue largely depends on the equilibrium between keratinocyte growth and differentiation of the HF. However, molecular nature in mice, rats, and humans, loss of transcription factor Foxn1 the keratinization processes is significantly impaired. Hence, this nude gene lack of function makes very similar hair pattern baldness in both human and nude mice (Foxn1nu/Foxn1nu). Thus highlighting the usefulness of mouse mutants and mouse genomics as a research tool for better molecular controls of human hair biology. To enhance research efforts of Foxn1 target gene regulation and the pharmacological manipulation of the nude phenotype are important open questions for promising research strategies related with Foxn1 biology. Taken together these issues may open the discovery of the investigative dermatology that promises the controls of epithelial differentiation in mammalian skin.

Published
2018
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21. Myxoid adrenocortical adenoma with a pseudoglandular pattern: a case report and literature review

Author

Zeng, Zhi, Gu, Li-Juan, Zhou, Zi-Ying, Liu, Lin, Yan, Hong-Lin, Huang, Ya-Bing, Wang, Ze-Sheng, Chen, Jun, and Yuan, Jing-Ping

Subjects
Case Report
Abstract

Adrenocortical adenoma is a benign neoplasm derived from cells of the adrenal cortex. The myxoid variant of this tumor is extremely rare. To our knowledge, only 23 cases of myxoid adrenocortical adenoma have been reported so far and 19 of them mentioned the pseudoglandular pattern. We reported a new case of 56-year-old Chinese female patient whose left adrenal gland was shown a neoplastic lesion by computed tomography (CT) and magnetic resonance (MR) imaging. Histopathological study showed that the mass was a myxoid adrenocortical adenoma with a pseudoglandular pattern. Then, we performed immunohistochemistry with 28 biomarkers to make differential diagnosis and found that tumor cells were diffusely positive for vimentin, melan-A, CD56, NSE and USP10, and focally positive for cytokeratin pan, cytokeratin 8/18 and VEGF. The labeling index of Ki-67 and Cyclin D1 were about 1% and 50%, respectively. No immunoreactivity was found for EMA, cytokeratin 7, HMB45, S-100, alpha-inhibin, calretinin, synaptophysin, chromogranin A, P53, EGFR, MMP2, DNA topo II alpha, CA125, E-cadherin, P63, P16 and Her-2. The patient has been followed up for 37 months after tumor resection and no evidence was found to suggest any local recurrence or any metastatic disease. Myxoid adrenocortical adenoma with a pseudoglandular pattern is extremely rare. The accurate diagnosis should be based on combined consideration of clinical characteristics, CT, MR imaging and pathological features, and should be distinguished from other retroperitoneal myxoid tumors.

Published
2017

24. Isolation and Purification of Novel Anti-Fungal Peptides from Hemolymph of Immunized Larvae of Housefly, Musca domestica

Author

Gu Li-Juan, Su Xiao-Qing, Sung Chang-Keun, and Wu Jian-Wei

Subjects
animal structures, biology, media_common.quotation_subject, fungi, Insect, biology.organism_classification, High-performance liquid chromatography, Biochemistry, Immunology, Hemolymph, Solid phase extraction, Housefly, Candida albicans, Defensin, Musca, media_common
Abstract

To isolate and purify anti-fungal active substances from immunized housefly (Musca domestica), low dose of Candida albicans was injected into the larvae of the housefly to induce the appearance of potent anti-fungal active substances in the hemolymph. This purification work was performed by the routine isolation and purification processes of protein, namely, solid phase extraction (SPE), SDS-PAGE electrophoresis, HPLC purification. Three 4~16 kDa peptides which exhibited antifungal activity against Candida albican and other fungi were isolated from induced hemolymph. Consequently, further anti-fungal activity study showed that these three peptides were different either in molecular weight or in anti-fungal activity. All isolated substances were proved to be active and resistant to high-temperature. It was deduced that these peptides isolated from induced housefly were novel members of the insect defensin family and they were inducible.

Published
2006

37. Evaluation of the Oral Acute Toxicity of Black Ginseng in Rats

Author

Lee, Mi-Ra, primary, Oh, Chang-Jin, additional, Li, Zheng, additional, Li, Jing-Jie, additional, Wang, Chun-Yan, additional, Wang, Zhen, additional, Gu, Li-Juan, additional, Lee, Sang-Hwa, additional, Lee, Jae-Il, additional, Lim, Beong-Ou, additional, and Sung, Chang-Keun, additional

Published
2011
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46. In vivo hair growth-stimulating effect of medicinal plant extract on BALB/c nude mice.

Author

Begum, Shahnaz, Gu, Li-Juan, Lee, Mi-Ra, Li, Zheng, Li, Jing-Jie, Hossain, Md. Jamil, Wang, Yun-Bo, and Sung, Chang Keun

Subjects
*HAIR physiology, *MEDICINAL plants, *PLANT extracts, *LABORATORY mice, *CHRYSANTHEMUMS, *ASTERACEAE
Abstract

Context: Chrysanthemum zawadskii var. latilobum (Asteraceae) (CZ) and Polygonum multiflorum Thunb. (Polygonaceae) (PM) have been used traditionally to treat different systemic diseases and acclaimed for various biological activities including hair growth. Objective: This study investigates the hair restoration efficacy of selected medicinal plant extracts on nude mice. Materials and methods: Nude mice genetically predisposed to pattern balding were used in this study. Topical methanol extracts of CZ and PM (10 mg/mouse/d) with standardized vehicle formulation, only vehicle (propylene glycol:ethanol:dimethyl sulfoxide, 67:30:3% v/v) and Minoxidil (2%) were applied daily for 40 consecutive days. Results: In our study, the maximum hair score (2.5 ± 0.29) was obtained in the CZ-treated group. Histological observation revealed a significant increase ( p < 0.001) in the number of hair follicles (HF) in CZ-treated mice (58.66 ± 3.72) and Minoxidil-treated mice (40 ± 2.71). Subsequently, immunohistochemical analysis also confirmed the follicular keratinocyte proliferation by detection of BrdU-labeling, S-phase cells in Minoxidil and CZ-treated mouse follicular bulb and outer root sheaths. Conclusion: Our study revealed the underlying mechanism of stimulating hair growth in athymic nude mice by repair the nu/nu follicular keratin differentiation defect. Thus, the topical application of CZ may represent a novel strategy for the management and therapy of certain forms of alopecia. [ABSTRACT FROM AUTHOR]

Published
2015
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49. Comparison between conidia and blastospores of Esteya vermicola, an endoparasitic fungus of the pinewood nematode, Bursaphelenchus xylophilus.

Author

Wang, Yun-Bo, Yang, Zhi-Hong, Yu, Jiao-Jiao, Zhang, Yong-An, Xue, Jian-Jie, Li, Zheng, Li, Jing-Jie, Wang, Chun-Yan, Wang, Zhen, Hou, Jin-Gang, Begum, Shahraz, Gu, Li-Juan, Lee, Mi-Ra, and Sung, Chang-Keun

Subjects
PINEWOOD nematode, CONIDIA, ENDOPARASITES, COMPARATIVE studies, PHYSIOLOGICAL control systems, WHEAT bran, FUNGAL spores
Abstract

Esteya vermicola, an endoparasitic fungus of Bursaphelenchus xylophilus, the pinewood nematode (PWN), exhibits great potential as a biological control agent against this nematode. E. vermicola produces blastospores in liquid media and aerial conidia on solid media. The agent was mass-produced using two kinds of culture media: S (50 % wheat bran and 50 % pine wood powder), L (0.5 g wheat bran and 0.5 g pinewood powder in 200 ml of potato dextrose broth), and two controls: SC (potato dextrose agar), LC (potato dextrose broth). Yields, multiple stress tolerance, storage life, new generation conidial number, and PWN mortality rates of the spores were measured in each of these four media and compared. The spore yields, new generation conidial number, and nematode mortality rates of blastospores were higher than those of conidia. Nevertheless, the conidia had a higher germination rate than the blastospores during the storage process and multiple stress treatments. Considering the number of spores surviving from the process of the storage and multiple stress treatments per unit of mass media, the blastospores from L survived most. Comprehensive analysis indicates that the L culture medium is the most optimal medium for mass production relatively. [ABSTRACT FROM AUTHOR]

Published
2013
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50. Ginsenosides Rb1 and Rd Regulate Proliferation of Mature Keratinocytes Through Induction of p63 Expression in Hair Follicles.

Author

Li, Zheng, Li, Jing‐Jie, Gu, Li‐Juan, Zhang, Dong‐Liang, Wang, Yun‐Bo, and Sung, Chang‐Keun

Abstract

Ginsenosides Rb1 and Rd are the two main types of ginsenosides in Panax ginseng and have been used as an additive to against alopecia. However, the mechanisms involved are largely unknown. To determine how ginsenosides prevent hair loss, we topically applied protopanaxadiol-type ginsenosides Rb1 and Rd over the shaved skin of B57CL/6 mice, and monitored and assessed them for 35 days. We then investigated the effects of ginsenosides on cell genesis in different phases of adult hair follicles (HFs), using 5-bromo-2′-deoxyuridine as a marker for dividing cells. Moreover, p63, a specific marker and a major regulator of keratinocyte progenitor cells of the multi-layered epithelia, was detected in epidermis. Results indicated that treatment with ginsenosides Rb1 and Rd increased cell proliferation in both anagen and telogen of HFs. However, it had no significant effect on the survival of cells in the bulge and upper follicle region. Investigation of p63 demonstrated that up-regulation of p63 expression in the matrix and outer root sheath might be one of the mechanisms by which ginsenosides Rb1 and Rd promote cell proliferation in HFs. Our study reveals a novel mechanism by which ginsenoside promotes hair growth through p63 induction in follicular keratinocytes and indicates that ginsenosides Rb1 and Rd might be developed as a therapeutic agent for the prevention of hair loss. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2013
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