578 results on '"Gu, Lian‐Quan"'
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2. Identification of small molecules capable of regulating conformational changes of telomeric G-quadruplex
3. Curcusone C induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2
4. Syntheses and antibacterial activity of soluble 9-bromo substituted indolizinoquinoline-5,12-dione derivatives
5. Conformation Selective Antibody Enables Genome Profiling and Leads to Discovery of Parallel G-Quadruplex in Human Telomeres
6. Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole
7. A simple structural modification to thiazole orange to improve the selective detection of G-quadruplexes
8. Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors
9. Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes
10. Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors
11. Design, synthesis, and biological evaluation of 2-arylethenylquinoline derivatives as multifunctional agents for the treatment of Alzheimer's disease
12. Synthesis and evaluation of new BODIPY-benzofuroquinoline conjugates for sensitive and selective DNA detection
13. Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors
14. Syntheses, spectroscopic characterization and application to DNA determination of novel fluorescent pyridophenazine derivatives
15. Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase
16. Facile syntheses of disubstituted bis(vinylquinolinium)benzene derivatives as G-quadruplex DNA binders
17. Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease
18. New quinazoline derivatives for telomeric G-quadruplex DNA: Effects of an added phenyl group on quadruplex binding ability
19. 3D-QSAR studies of azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives as anti-AChE and anti-AD agents by the CoMFA method
20. 12-N-Methylated 5,6-dihydrobenzo[c]acridine derivatives: A new class of highly selective ligands for c-myc G-quadruplex DNA
21. Disubstituted 1,8-dipyrazolcarbazole derivatives as a new type of c-myc G-quadruplex binding ligands
22. Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation
23. Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA
24. Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer’s disease
25. Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents
26. Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase
27. Synthesis, antimicrobial activity and possible mechanism of action of 9-bromo-substituted indolizinoquinoline-5,12-dione derivatives
28. Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors
29. Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation
30. Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation
31. Synthesis and antiproliferative activity of indolizinophthalazine-5,12-dione derivatives, DNA topoisomerase IB inhibitors
32. Synthesis and evaluation of graveoline and graveolinine derivatives with potent anti-angiogenesis activities
33. Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors
34. Bisaryldiketene derivatives: A new class of selective ligands for c-myc G-quadruplex DNA
35. Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule
36. Natural tanshinone-like heterocyclic-fused ortho-quinones from regioselective Diels–Alder reaction: Synthesis and cytotoxicity evaluation
37. Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase
38. New insights from molecular dynamic simulation studies of the multiple binding modes of a ligand with G-quadruplex DNA
39. Oxoisoaporphine alkaloid derivatives: Synthesis, DNA binding affinity and cytotoxicity
40. Trityl-derivatized carbohydrates immobilized on a polystyrene microplate
41. Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors
42. 9- N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c- myc
43. Synthesis, cytotoxic activities and structure–activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5,12-dione derivatives
44. Synthesis of zwitterionic 4-hydroxy-2(1 H)-quinolinone derivatives
45. Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat
46. Mixture of poly(ethylene glycol) and water as environmentally friendly media for efficient enantioselective transfer hydrogenation and catalyst recycling
47. Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin
48. 9-Substituted berberine derivatives as G-quadruplex stabilizing ligands in telomeric DNA
49. G-Quadruplex DNA and its Ligands in Anticancer Therapy
50. α-Glucosidase inhibition of natural curcuminoids and curcumin analogs
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