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1,259 results on '"Gu, Mancang"'

1. Effects of Gust on Aerodynamic Power Consumption of Flapping Wings

Author

Gu, Mancang, Zhang, Yanlai, Wu, Jianghao, Zhou, Chao, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Möller, Sebastian, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Zhang, Junjie James, Series Editor, Fu, Wenxing, editor, Gu, Mancang, editor, and Niu, Yifeng, editor

Published
2023
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5. Investment Portfolio Establishment : Based on Mean, Variance and Sharpe Ratio

Author

Yang, Han, Li, Jiachen, Shi, Rong, Gu, Mancang, Li, Kan, Editor-in-Chief, Li, Qingyong, Associate Editor, Fournier-Viger, Philippe, Series Editor, Hong, Wei-Chiang, Series Editor, Liang, Xun, Series Editor, Wang, Long, Series Editor, Xu, Xuesong, Series Editor, Yen, Jerome, editor, Abedin, Mohammad Zoynul, editor, and Wan Ngah, Wan Azman Saini Bin, editor

Published
2023
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14. Albumin conjugation promotes arsenic trioxide transport through alkaline phosphatase-associated transcytosis in MUC4 wildtype pancreatic cancer cells

Author

Chen, Kaidi, primary, Cheng, Xiao, additional, Xue, Shuai, additional, Chen, Junyan, additional, Zhang, Xu, additional, Qi, Yuwei, additional, Chen, Rong, additional, Zhang, Yan, additional, Wang, Hangjie, additional, Li, Wei, additional, Cheng, Guilin, additional, Huang, Ye, additional, Xiong, Yang, additional, Chen, Liping, additional, Mu, Chaofeng, additional, and Gu, Mancang, additional

Published
2023
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15. The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome

Author

Kosumi, Keisuke, Hamada, Tsuyoshi, Koh, Hideo, Borowsky, Jennifer, Bullman, Susan, Twombly, Tyler S., Nevo, Daniel, Masugi, Yohei, Liu, Li, da Silva, Annacarolina, Chen, Yang, Du, Chunxia, Gu, Mancang, Li, Chenxi, Li, Wanwan, Liu, Hongli, Shi, Yan, Mima, Kosuke, Song, Mingyang, Nosho, Katsuhiko, Nowak, Jonathan A., Nishihara, Reiko, Baba, Hideo, Zhang, Xuehong, Wu, Kana, Wang, Molin, Huttenhower, Curtis, Garrett, Wendy S., Meyerson, Matthew L., Lennerz, Jochen K., Giannakis, Marios, Chan, Andrew T., Meyerhardt, Jeffrey A., Fuchs, Charles S., and Ogino, Shuji

Published
2018
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16. Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum

Author

Liu, Li, Tabung, Fred K., Zhang, Xuehong, Nowak, Jonathan A., Qian, Zhi Rong, Hamada, Tsuyoshi, Nevo, Daniel, Bullman, Susan, Mima, Kosuke, Kosumi, Keisuke, da Silva, Annacarolina, Song, Mingyang, Cao, Yin, Twombly, Tyler S., Shi, Yan, Liu, Hongli, Gu, Mancang, Koh, Hideo, Li, Wanwan, Du, Chunxia, Chen, Yang, Li, Chenxi, Li, Wenbin, Mehta, Raaj S., Wu, Kana, Wang, Molin, Kostic, Aleksander D., Giannakis, Marios, Garrett, Wendy S., Hutthenhower, Curtis, Chan, Andrew T., Fuchs, Charles S., Nishihara, Reiko, Ogino, Shuji, and Giovannucci, Edward L.

Published
2018
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17. THZ1: Towards KRAS mutation‐based precision medicine against pancreatic ductal adenocarcinoma.

Author

Qin, Yansong, Gu, Mancang, Shi, Yan, and Huang, Lei

Subjects
*PANCREATIC duct, *PANCREATIC tumors, *INDIVIDUALIZED medicine, *RAS oncogenes, *PANCREATIC intraepithelial neoplasia, *ADENOCARCINOMA, *SOMATIC mutation
Abstract

This article discusses the potential of the targeted agent THZ1 in the treatment of pancreatic ductal adenocarcinoma (PDAC), a challenging and often fatal form of cancer. The study highlights the importance of KRAS mutations in driving the development of PDAC and explores how THZ1 selectively inhibits PDAC cells with specific KRAS mutant subtypes. The research suggests that genetic profiling, particularly identifying specific KRAS mutation subtypes, should be integrated into the diagnostic and therapeutic decision-making processes for PDAC. The study also emphasizes the need for further research to explore the efficacy of THZ1 in PDACs with different genetic alterations and to investigate its long-term safety and impact on patient quality of life. Overall, the study represents a significant step towards precision medicine in PDAC and offers hope for improved treatment options in the future. [Extracted from the article]

Published
2024
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18. Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer

Author

Yurgelun, Matthew B., Chittenden, Anu B., Morales-Oyarvide, Vicente, Rubinson, Douglas A., Dunne, Richard F., Kozak, Margaret M., Qian, Zhi Rong, Welch, Marisa W., Brais, Lauren K., Da Silva, Annacarolina, Bui, Justin L., Yuan, Chen, Li, Tingting, Li, Wanwan, Masuda, Atsuhiro, Gu, Mancang, Bullock, Andrea J., Chang, Daniel T., Clancy, Thomas E., Linehan, David C., Findeis-Hosey, Jennifer J., Doyle, Leona A., Thorner, Aaron R., Ducar, Matthew D., Wollison, Bruce M., Khalaf, Natalia, Perez, Kimberly, Syngal, Sapna, Aguirre, Andrew J., Hahn, William C., Meyerson, Matthew L., Fuchs, Charles S., Ogino, Shuji, Hornick, Jason L., Hezel, Aram F., Koong, Albert C., Nowak, Jonathan A., and Wolpin, Brian M.

Published
2019
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19. Supplementary Figures 1 and 2 and Supplementary Tables 1 through 5 from MicroRNA let-7, T Cells, and Patient Survival in Colorectal Cancer

Author

Dou, Ruoxu, primary, Nishihara, Reiko, primary, Cao, Yin, primary, Hamada, Tsuyoshi, primary, Mima, Kosuke, primary, Masuda, Atsuhiro, primary, Masugi, Yohei, primary, Shi, Yan, primary, Gu, Mancang, primary, Li, Wanwan, primary, da Silva, Annacarolina, primary, Nosho, Katsuhiko, primary, Zhang, Xuehong, primary, Meyerhardt, Jeffrey A., primary, Giovannucci, Edward L., primary, Chan, Andrew T., primary, Fuchs, Charles S., primary, Qian, Zhi Rong, primary, and Ogino, Shuji, primary

Published
2023
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20. Supplementary Table S2 from Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer

Author

Masugi, Yohei, primary, Nishihara, Reiko, primary, Hamada, Tsuyoshi, primary, Song, Mingyang, primary, da Silva, Annacarolina, primary, Kosumi, Keisuke, primary, Gu, Mancang, primary, Shi, Yan, primary, Li, Wanwan, primary, Liu, Li, primary, Nevo, Daniel, primary, Inamura, Kentaro, primary, Cao, Yin, primary, Liao, Xiaoyun, primary, Nosho, Katsuhiko, primary, Chan, Andrew T., primary, Giannakis, Marios, primary, Bass, Adam J., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Rodig, Scott J., primary, Fuchs, Charles S., primary, Qian, Zhi Rong, primary, Nowak, Jonathan A., primary, and Ogino, Shuji, primary

Published
2023
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21. Supplementay Figures S1-3 from Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer

Author

Masugi, Yohei, primary, Nishihara, Reiko, primary, Hamada, Tsuyoshi, primary, Song, Mingyang, primary, da Silva, Annacarolina, primary, Kosumi, Keisuke, primary, Gu, Mancang, primary, Shi, Yan, primary, Li, Wanwan, primary, Liu, Li, primary, Nevo, Daniel, primary, Inamura, Kentaro, primary, Cao, Yin, primary, Liao, Xiaoyun, primary, Nosho, Katsuhiko, primary, Chan, Andrew T., primary, Giannakis, Marios, primary, Bass, Adam J., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Rodig, Scott J., primary, Fuchs, Charles S., primary, Qian, Zhi Rong, primary, Nowak, Jonathan A., primary, and Ogino, Shuji, primary

Published
2023
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22. Data from Metabolic Profiling of Formalin-Fixed Paraffin-Embedded Tissues Discriminates Normal Colon from Colorectal Cancer

Author

Arima, Kota, primary, Lau, Mai Chan, primary, Zhao, Melissa, primary, Haruki, Koichiro, primary, Kosumi, Keisuke, primary, Mima, Kosuke, primary, Gu, Mancang, primary, Väyrynen, Juha P., primary, Twombly, Tyler S., primary, Baba, Yoshifumi, primary, Fujiyoshi, Kenji, primary, Kishikawa, Junko, primary, Guo, Chunguang, primary, Baba, Hideo, primary, Richards, William G., primary, Chan, Andrew T., primary, Nishihara, Reiko, primary, Meyerhardt, Jeffrey A., primary, Nowak, Jonathan A., primary, Giannakis, Marios, primary, Fuchs, Charles S., primary, and Ogino, Shuji, primary

Published
2023
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23. Data from Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status

Author

Hamada, Tsuyoshi, primary, Zhang, Xuehong, primary, Mima, Kosuke, primary, Bullman, Susan, primary, Sukawa, Yasutaka, primary, Nowak, Jonathan A., primary, Kosumi, Keisuke, primary, Masugi, Yohei, primary, Twombly, Tyler S., primary, Cao, Yin, primary, Song, Mingyang, primary, Liu, Li, primary, da Silva, Annacarolina, primary, Shi, Yan, primary, Gu, Mancang, primary, Li, Wanwan, primary, Koh, Hideo, primary, Nosho, Katsuhiko, primary, Inamura, Kentaro, primary, Keum, NaNa, primary, Wu, Kana, primary, Meyerhardt, Jeffrey A., primary, Kostic, Aleksandar D., primary, Huttenhower, Curtis, primary, Garrett, Wendy S., primary, Meyerson, Matthew, primary, Giovannucci, Edward L., primary, Chan, Andrew T., primary, Fuchs, Charles S., primary, Nishihara, Reiko, primary, Giannakis, Marios, primary, and Ogino, Shuji, primary

Published
2023
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24. Data from MicroRNA let-7, T Cells, and Patient Survival in Colorectal Cancer

Author

Dou, Ruoxu, primary, Nishihara, Reiko, primary, Cao, Yin, primary, Hamada, Tsuyoshi, primary, Mima, Kosuke, primary, Masuda, Atsuhiro, primary, Masugi, Yohei, primary, Shi, Yan, primary, Gu, Mancang, primary, Li, Wanwan, primary, da Silva, Annacarolina, primary, Nosho, Katsuhiko, primary, Zhang, Xuehong, primary, Meyerhardt, Jeffrey A., primary, Giovannucci, Edward L., primary, Chan, Andrew T., primary, Fuchs, Charles S., primary, Qian, Zhi Rong, primary, and Ogino, Shuji, primary

Published
2023
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25. Data from Tumor PDCD1LG2 (PD-L2) Expression and the Lymphocytic Reaction to Colorectal Cancer

Author

Masugi, Yohei, primary, Nishihara, Reiko, primary, Hamada, Tsuyoshi, primary, Song, Mingyang, primary, da Silva, Annacarolina, primary, Kosumi, Keisuke, primary, Gu, Mancang, primary, Shi, Yan, primary, Li, Wanwan, primary, Liu, Li, primary, Nevo, Daniel, primary, Inamura, Kentaro, primary, Cao, Yin, primary, Liao, Xiaoyun, primary, Nosho, Katsuhiko, primary, Chan, Andrew T., primary, Giannakis, Marios, primary, Bass, Adam J., primary, Hodi, F. Stephen, primary, Freeman, Gordon J., primary, Rodig, Scott J., primary, Fuchs, Charles S., primary, Qian, Zhi Rong, primary, Nowak, Jonathan A., primary, and Ogino, Shuji, primary

Published
2023
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26. Supplementary Figure S1 from Metabolic Profiling of Formalin-Fixed Paraffin-Embedded Tissues Discriminates Normal Colon from Colorectal Cancer

Author

Arima, Kota, primary, Lau, Mai Chan, primary, Zhao, Melissa, primary, Haruki, Koichiro, primary, Kosumi, Keisuke, primary, Mima, Kosuke, primary, Gu, Mancang, primary, Väyrynen, Juha P., primary, Twombly, Tyler S., primary, Baba, Yoshifumi, primary, Fujiyoshi, Kenji, primary, Kishikawa, Junko, primary, Guo, Chunguang, primary, Baba, Hideo, primary, Richards, William G., primary, Chan, Andrew T., primary, Nishihara, Reiko, primary, Meyerhardt, Jeffrey A., primary, Nowak, Jonathan A., primary, Giannakis, Marios, primary, Fuchs, Charles S., primary, and Ogino, Shuji, primary

Published
2023
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27. Supplementary Data from Metabolic Profiling of Formalin-Fixed Paraffin-Embedded Tissues Discriminates Normal Colon from Colorectal Cancer

Author

Arima, Kota, primary, Lau, Mai Chan, primary, Zhao, Melissa, primary, Haruki, Koichiro, primary, Kosumi, Keisuke, primary, Mima, Kosuke, primary, Gu, Mancang, primary, Väyrynen, Juha P., primary, Twombly, Tyler S., primary, Baba, Yoshifumi, primary, Fujiyoshi, Kenji, primary, Kishikawa, Junko, primary, Guo, Chunguang, primary, Baba, Hideo, primary, Richards, William G., primary, Chan, Andrew T., primary, Nishihara, Reiko, primary, Meyerhardt, Jeffrey A., primary, Nowak, Jonathan A., primary, Giannakis, Marios, primary, Fuchs, Charles S., primary, and Ogino, Shuji, primary

Published
2023
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28. Supplementary Data from Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status

Author

Hamada, Tsuyoshi, primary, Zhang, Xuehong, primary, Mima, Kosuke, primary, Bullman, Susan, primary, Sukawa, Yasutaka, primary, Nowak, Jonathan A., primary, Kosumi, Keisuke, primary, Masugi, Yohei, primary, Twombly, Tyler S., primary, Cao, Yin, primary, Song, Mingyang, primary, Liu, Li, primary, da Silva, Annacarolina, primary, Shi, Yan, primary, Gu, Mancang, primary, Li, Wanwan, primary, Koh, Hideo, primary, Nosho, Katsuhiko, primary, Inamura, Kentaro, primary, Keum, NaNa, primary, Wu, Kana, primary, Meyerhardt, Jeffrey A., primary, Kostic, Aleksandar D., primary, Huttenhower, Curtis, primary, Garrett, Wendy S., primary, Meyerson, Matthew, primary, Giovannucci, Edward L., primary, Chan, Andrew T., primary, Fuchs, Charles S., primary, Nishihara, Reiko, primary, Giannakis, Marios, primary, and Ogino, Shuji, primary

Published
2023
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29. The suppressive efficacy of THZ1 depends on KRAS mutation subtype and is associated with super‐enhancer activity and the PI3K/AKT/mTOR signalling in pancreatic ductal adenocarcinoma: A hypothesis‐generating study.

Author

Huang, Lei, Yang, Hui, Chen, Kaidi, Yuan, Jing, Li, Jie, Dai, Guanghai, Gu, Mancang, and Shi, Yan

Subjects
PANCREATIC duct, GENE enhancers, RAS oncogenes, RNA polymerase II, GENETIC mutation, TRANSCRIPTION factors, ADENOCARCINOMA
Abstract

Background: Inhibition of CDK7, a potent transcription regulator, may bring new hope for treating pancreatic ductal adenocarcinoma (PDAC), which is featured by large genetic heterogeneity and abundant KRAS mutations. This investigation aimed at exploring the discrepant efficacies of THZ1, a small‐molecule covalent CDK7 inhibitor, on PDACs with different KRAS mutations and the underlying mechanisms. Methods: Associations of CDK7 expression with survival by KRAS mutations were first assessed. Effects of THZ1 on PDAC by different KRAS mutations were then investigated in vitro and in vivo. Moreover, the effects of THZ1 on gene transcription and phosphorylation of RNA polymerase II (RNAPOLII) in different KRAS mutant PDACs were assessed, and the effect of THZ1 on super‐enhancer activity was evaluated using chromatin immunoprecipitation sequencing. Lastly, the effects of THZ1 on the binding of H3K27ac to PIK3CA and on the PI3K/AKT/mTOR signalling were analysed. Results: High CDK7 expression was significantly linked to worse survival within PDAC patients carrying KRAS‐G12V mutation but not in those with KRAS‐G12D mutation. The apoptosis‐inducing effect of THZ1 was markedly stronger in KRAS‐G12V PDAC than KRAS‐G12D cancer. THZ1 significantly inhibited the growth of xenograft tumour with KRAS‐G12V mutation, and the inhibition was markedly stronger than for KRAS‐G12D tumour. In mini‐cell‐derived xenograft (CDX) models, THZ1 significantly suppressed KRAS‐G12V PDAC but not KRAS‐G12D cancer. THZ1 significantly suppressed the phosphorylation of RNAPOLII, and this effect was stronger in KRAS‐G12V PDAC (especially at ser5). KRAS‐G12V PDAC had more H3K27ac‐binding super‐enhancers, and the inhibition of THZ1 on super‐enhancer activity was also stronger in KRAS‐G12V PDAC. Furthermore, THZ1 significantly weakened the binding of H3K27ac to PIK3CA in KRAS‐G12V PDAC. THZ1 significantly suppressed the PI3K/AKT/mTOR pathway and its downstream markers, and this effect was stronger in KRAS‐G12V cells. Conclusions: In this hypothesis‐generating study, THZ1 might selectively inhibit certain PDACs with KRAS‐G12V mutation more potently compared with some other PDACs with KRAS‐G12D mutation, which might be associated with its effect on super‐enhancer activity and the PI3K/AKT/mTOR signalling. Our findings might offer novel key clues for the precise management of PDAC and important evidence for future targeted trial design. Highlights: THZ1 had a stronger effect on PDAC‐bearing KRAS‐G12V mutation than G12D mutation.Suppressive effect of THZ1 on phosphorylation of RNAPOLII was stronger in KRAS‐G12V than KRAS‐G12D PDAC.Inhibition of THZ1 on super‐enhancer activity and H3K27ac binding to PIK3CA was stronger in KRAS‐G12V PDAC.Suppressive effect of THZ1 on PI3K/AKT/mTOR pathway was stronger in KRAS‐G12V PDAC. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Supplementary Table S1 from MicroRNA MIR21 (miR-21) and PTGS2 Expression in Colorectal Cancer and Patient Survival

Author

Mima, Kosuke, primary, Nishihara, Reiko, primary, Yang, Juhong, primary, Dou, Ruoxu, primary, Masugi, Yohei, primary, Shi, Yan, primary, da Silva, Annacarolina, primary, Cao, Yin, primary, Song, Mingyang, primary, Nowak, Jonathan, primary, Gu, Mancang, primary, Li, Wanwan, primary, Morikawa, Teppei, primary, Zhang, Xuehong, primary, Wu, Kana, primary, Baba, Hideo, primary, Giovannucci, Edward L., primary, Meyerhardt, Jeffrey A., primary, Chan, Andrew T., primary, Fuchs, Charles S., primary, Qian, Zhi Rong, primary, and Ogino, Shuji, primary

Published
2023
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33. Cell Cycle Protein Expression in Neuroendocrine Tumors: Association of CDK4/CDK6, CCND1, and Phosphorylated Retinoblastoma Protein With Proliferative Index

Author

Shi, Yan, Qian, Zhi Rong, Zhang, Sui, Li, Wanwan, Masugi, Yohei, Li, Tingting, Chan, Jennifer A., Yang, Juhong, Da Silva, Annacarolina, Gu, Mancang, Liu, Li, Hamada, Tsuyoshi, Kosumi, Keisuke, Dutton, Trevor, Brais, Lauren K., Nishihara, Reiko, Fuchs, Charles S., Ogino, Shuji, and Kulke, Matthew H.

Published
2017
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34. Chemical profiling and identification of anti-osteoporosis chemical-markers of Cinnamomum cassia (L.) presl extracts using GC-MS and spectrum-activity analyses.

Author

Zhao, Shan, Wu, Yali, Qian, Yafang, Qian, Yifan, Xue, Shuai, Chen, Junyan, Zeng, Qinghe, and Gu, Mancang

Subjects
GAS chromatography/Mass spectrometry (GC-MS), CASSIA (Genus), CINNAMOMUM, TRADITIONAL medicine, CINNAMON
Abstract

Cinnamomum cassia (L.) Presl (cinnamon), an important folk medicine is widely used to prevent osteoporosis for long time in China. Our study aimed to investigate the anti-osteoporosis activity and mechanisms of cinnamon extracts obtained by supercritical CO2 extraction (SFE) and identify activity associated chemical components by gas chromatography-mass spectrometry. The cinnamon SFE exhibited superior anti-osteoporosis efficacy in an ovariectomised mice model to common alcohol extracts. It could induce calcified nodules and ALP activity, upregulate the mRNA expression of ALP, BMP-2, and RUNX2 in MC3T3-E1 cells. The major chemical classes of cinnamon extracts were alcohol esters (28.2%), and terpenes (16.1%). The spectrum-activity analysis indicated that the potential chemical-markers of extracts could be (E)-Cinnamaldehyde, γ-Sitosterol, and (Z, Z)-9,12-Octadecadienoic acid, which could induce the proliferation and ALP activity in MC3T3-E1 cells. Our study revealed the promising applications of the cinnamon SFE in prevention of osteoporosis, and identified its anti-osteoporosis associated compounds. [ABSTRACT FROM AUTHOR]

Published
2023
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35. N-Butanol Extract of Modified You-Gui-Yin Attenuates Osteoclastogenesis and Ameliorates Osteoporosis by Inhibiting RANKL-Mediated NF-κB Signaling

Author

Zeng, Qinghe, primary, Xu, Rui, additional, Ling, Houfu, additional, Zhao, Shan, additional, Wang, Xu, additional, Yuan, Wenhua, additional, Gu, Mancang, additional, Xu, Taotao, additional, Wang, Pinger, additional, Ruan, Hongfeng, additional, Jin, Hongting, additional, Qu, Hangbo, additional, Ye, Fusheng, additional, and Chen, Jiali, additional

Published
2022
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36. Fusobacterium nucleatum in Colorectal Carcinoma Tissue According to Tumor Location

Author

Mima, Kosuke, Cao, Yin, Chan, Andrew T, Qian, Zhi Rong, Nowak, Jonathan A, Masugi, Yohei, Shi, Yan, Song, Mingyang, da Silva, Annacarolina, Gu, Mancang, Li, Wanwan, Hamada, Tsuyoshi, Kosumi, Keisuke, Hanyuda, Akiko, Liu, Li, Kostic, Aleksandar D, Giannakis, Marios, Bullman, Susan, Brennan, Caitlin A, Milner, Danny A, Baba, Hideo, Garraway, Levi A, Meyerhardt, Jeffrey A, Garrett, Wendy S, Huttenhower, Curtis, Meyerson, Matthew, Giovannucci, Edward L, Fuchs, Charles S, Nishihara, Reiko, and Ogino, Shuji

Published
2016
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37. Association of Alterations in Main Driver Genes With Outcomes of Patients With Resected Pancreatic Ductal Adenocarcinoma

Author

Qian, Zhi Rong, Rubinson, Douglas A., Nowak, Jonathan A., Morales-Oyarvide, Vicente, Dunne, Richard F., Kozak, Margaret M., Welch, Marisa W., Brais, Lauren K., Da Silva, Annacarolina, Li, Tingting, Li, Wanwan, Masuda, Atsuhiro, Yang, Juhong, Shi, Yan, Gu, Mancang, Masugi, Yohei, Bui, Justin, Zellers, Caitlin L., Yuan, Chen, Babic, Ana, Khalaf, Natalia, Aguirre, Andrew, Ng, Kimmie, Miksad, Rebecca A., Bullock, Andrea J., Chang, Daniel T., Tseng, Jennifer F., Clancy, Thomas E., Linehan, David C., Findeis-Hosey, Jennifer J., Doyle, Leona A., Thorner, Aaron R., Ducar, Matthew, Wollison, Bruce, Laing, Angelica, Hahn, William C., Meyerson, Matthew, Fuchs, Charles S., Ogino, Shuji, Hornick, Jason L., Hezel, Aram F., Koong, Albert C., and Wolpin, Brian M.

Published
2018
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40. Fractions of Shen-Sui-Tong-Zhi Formula Enhance Osteogenesis Via Activation of β-Catenin Signaling in Growth Plate Chondrocytes

Author

Xu, Rui, primary, Zeng, Qinghe, additional, Xia, Chenjie, additional, Chen, Jiali, additional, Wang, Pinger, additional, Zhao, Shan, additional, Yuan, Wenhua, additional, Lou, Zhaohuan, additional, Lin, Houfu, additional, Xia, Hanting, additional, Lv, Shuaijie, additional, Xu, Taotao, additional, Tong, Peijian, additional, Gu, Mancang, additional, and Jin, Hongting, additional

Published
2021
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44. Metabolic Profiling of Formalin-Fixed Paraffin-Embedded Tissues Discriminates Normal Colon from Colorectal Cancer

Author

Arima, Kota, primary, Lau, Mai Chan, additional, Zhao, Melissa, additional, Haruki, Koichiro, additional, Kosumi, Keisuke, additional, Mima, Kosuke, additional, Gu, Mancang, additional, Väyrynen, Juha P., additional, Twombly, Tyler S., additional, Baba, Yoshifumi, additional, Fujiyoshi, Kenji, additional, Kishikawa, Junko, additional, Guo, Chunguang, additional, Baba, Hideo, additional, Richards, William G., additional, Chan, Andrew T., additional, Nishihara, Reiko, additional, Meyerhardt, Jeffrey A., additional, Nowak, Jonathan A., additional, Giannakis, Marios, additional, Fuchs, Charles S., additional, and Ogino, Shuji, additional

Published
2020
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45. Night-Shift Work Duration and Risk of Colorectal Cancer According to IRS1 and IRS2 Expression

Author

Shi, Yan, primary, Liu, Li, additional, Hamada, Tsuyoshi, additional, Nowak, Jonathan A., additional, Giannakis, Marios, additional, Ma, Yanan, additional, Song, Mingyang, additional, Nevo, Daniel, additional, Kosumi, Keisuke, additional, Gu, Mancang, additional, Kim, Sun A., additional, Morikawa, Teppei, additional, Wu, Kana, additional, Sui, Jing, additional, Papantoniou, Kyriaki, additional, Wang, Molin, additional, Chan, Andrew T., additional, Fuchs, Charles S., additional, Meyerhardt, Jeffrey A., additional, Giovannucci, Edward, additional, Ogino, Shuji, additional, Schernhammer, Eva S., additional, Nishihara, Reiko, additional, and Zhang, Xuehong, additional

Published
2020
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48. Wing rapid responses and aerodynamics of fruit flies during headwind gust perturbations

Author

Jianghao Wu, Yanlai Zhang, and Gu Mancang

Subjects
Models, Anatomic, 0209 industrial biotechnology, Biophysics, Wind, 02 engineering and technology, Rotation, Models, Biological, Biochemistry, 020901 industrial engineering & automation, Wing kinematics, Animals, Wings, Animal, Computer Simulation, Engineering (miscellaneous), Lift-to-drag ratio, Wing, Aerodynamics, Mechanics, 021001 nanoscience & nanotechnology, Biomechanical Phenomena, Aerodynamic force, Tailwind, Flight, Animal, Wind gust, Molecular Medicine, Environmental science, Drosophila, 0210 nano-technology, Biotechnology
Abstract

Insects are the main source of inspiration for flapping-wing micro air vehicles (FWMAVs). They frequently encounter wind gust perturbations in natural environments, and effectively cope with these perturbations. Here, we investigated the rapid gust response of flies to instruct the gust stability design of FWMAVs. A novel method to produce impulsive wind gusts that lasted less than 30 ms was designed to observe flies' rapid responses. Headwind gust perturbations were imposed on 14 tethered fruit flies, and the corresponding wing motions during perturbations were recorded by three high-speed cameras. The numerical simulation method was then applied to analyze aerodynamic forces and moments induced by the changes in wing kinematics. Results shows that flies mainly utilize three strategies against headwind gust perturbations, including decreasing the magnitude of stroke positional angle at ventral stroke reversal, delayed rotation and making the deviation angles in upstroke and downstroke closer (i.e. the wing tip trajectories of upstroke and downstroke tend be closer). Consequently, flies resist increments in lift and drag induced by the headwind gusts. However, flies seem to care little about changes in pitch moment in tethered conditions. These results provide useful suggestions for the stability control of FWMAVs during headwind gust perturbations.

Published
2020

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