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140 results on '"Gu, Xiaoxiao"'

7. Detection of emerging HoBi-like Pestivirus (BVD-3) during an epidemiological investigation of bovine viral diarrhea virus in Xinjiang: a first-of-its-kind report

Author

Yang, Ningning, primary, Xu, Mingguo, additional, Ma, Zhenguo, additional, Li, Honghuan, additional, Song, Shengnan, additional, Gu, Xiaoxiao, additional, Liu, Jingnan, additional, Yang, Zhonglian, additional, Zhu, Hongji, additional, Ma, Hailong, additional, Yi, Jihai, additional, Wang, Yong, additional, Wang, Zhen, additional, Sheng, Jinliang, additional, and Chen, Chuangfu, additional

Published
2023
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9. Isolation, identification, molecular typing, and drug resistance of Escherichia coli from infected cattle and sheep in Xinjiang, China

Author

Gu, Xiaoxiao, primary, Ma, Xue, additional, Wu, Qin, additional, Tao, Qiaoxiaoci, additional, Chai, Yingjin, additional, Zhou, Xia, additional, Han, Mengli, additional, Li, Jie, additional, Huang, Xin, additional, Wu, Tongzhong, additional, Zhang, Xingxing, additional, Zhong, Fagang, additional, Cao, Yiheng, additional, and Zhang, Liyuan, additional

Published
2023
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13. List of Contributors

Author

Dai, Zengying, primary, Fan, Suqin, additional, Gao, Chuancai, additional, Gu, Qiaoqiao, additional, Gu, Xiaoxiao, additional, Hermund, Ditte B., additional, Ioannou, Efstathia, additional, Jiang, Jinju, additional, Koutsaviti, Aikaterini, additional, Liu, Haiyan, additional, Liu, Ranran, additional, Pangestuti, Ratih, additional, Patel, Seema, additional, Qin, Yimin, additional, Qu, Guiyan, additional, Roussis, Vassilios, additional, Shen, Peili, additional, Shi, Shaojuan, additional, Siahaan, Evi A., additional, Sun, Zhanyi, additional, Wang, Chunxia, additional, Wang, Jue, additional, Yin, Zongmei, additional, Zhang, Demeng, additional, Zhang, Mengxue, additional, Zhang, Pengpeng, additional, Zhang, Wenchao, additional, Zhao, Lili, additional, and Zhao, Ting, additional

Published
2018
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20. Effects of Bacillus cereus PAS38 on Immune-Related Differentially Expressed Genes of Spleen in Broilers

Author

Jiajun Li, Kangcheng Pan, Bo Jing, Dongmei Zhang, Xueqin Ni, Jiao Zhang, Dong Zeng, Gu Xiaoxiao, Jie Feng, Zhenhua Wang, and Jianzhen Li

Subjects
0301 basic medicine, 030106 microbiology, Bacillus cereus, Spleen, Biology, Microbiology, Newcastle disease, law.invention, 03 medical and health sciences, Probiotic, Immune system, law, medicine, Animals, Immunologic Factors, Molecular Biology, Probiotics, Vaccination, Broiler, biology.organism_classification, 030104 developmental biology, medicine.anatomical_structure, Cereus, bacteria, Molecular Medicine, Chickens
Abstract

This study mainly explored the immunomodulatory mechanisms of the probiotic Bacillus cereus PAS38 (PB) on broiler spleen. A total of 120 avian white feather broilers were randomly divided into 4 groups (N = 30), as follows: control (CNTL, fed with basal diet), PB (fed with diet supplemented with probiotic B. cereus PAS38), vaccine (VAC, fed with basal diet and injected with Newcastle disease virus vaccine), and vaccine + PB group (PBVAC, fed with basal diet supplemented with B. cereus PAS38 and injected with NDV vaccine). The experiment was conducted for 42 days. Twelve spleens were collected from four different groups, weighed, and cut into histological sections, and transcriptome analysis was performed using RNA-seq. Results of the spleen and histological section relative weights showed that feeding with probiotic B. cereus PAS38 and vaccination had a similar tendency to promote spleen development. Compared with the CNTL group, 21 immune-related genes were significantly downregulated in the PB and PBVAC groups. These genes were mainly involved in attenuating inflammatory response. The upregulated antimicrobial peptide NK-lysin and guanylate-binding protein 1 expression levels indicated that this strain enhanced the body's antimicrobial capacity. B. cereus PAS38 also amplified the broilers' immune response to the vaccine, which mainly reflected on nonspecific immunity. Hence, probiotic B. cereus PAS38 can regulate and promote the immune function of broilers.

Published
2019

21. Mesoporous Colloidal Photonic Crystal Particles for Intelligent Drug Delivery

Author

Guopu Chen, Peihua Lu, Zhuoyue Chen, Gu Xiaoxiao, Yuxiao Liu, Changmin Shao, Huan Wang, and Yuanjin Zhao

Subjects
Materials science, Dispersity, Microfluidics, Mice, Nude, Nanoparticle, Antineoplastic Agents, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Mice, Drug Delivery Systems, Animals, Humans, General Materials Science, Colloids, Hep G2 Cells, Neoplasms, Experimental, Colloidal crystal, 021001 nanoscience & nanotechnology, Xenograft Model Antitumor Assays, 0104 chemical sciences, Nanopore, Drug delivery, Nanoparticles, Particle, 0210 nano-technology, Mesoporous material, Porosity
Abstract

Particle-based delivery systems demonstrate a pregnant value in the fields of drug research and development. Efforts to advance this technology focus on the fabrication of functional particles with enhanced efficiency and performance for drug delivery. Here, we present a new type of mesoporous colloidal photonic crystal particle (MCPCP)-based drug-delivery system with distinct features. As the MCPCPs were constructed by self-assembling monodisperse mesoporous nanoparticles in microfluidic droplet templates, they were composed of hierarchical macro- and mesoporous structures and could provide plenty of nanopores and interconnected nanochannels for synergistic loading of both micro- and macromolecule drugs with large quantity and sustained release. In addition, by integrating the stimuli-responsive poly( N-isopropylacrylamide) hydrogel into the MCPCPs and employing it as a "gating" to control the opening of the macro- and mesopores, the MCPCP delivery systems were imparted with the function of controllable release. More attractively, as the average refractive index of the MCPCPs was decreased during the release of the loaded actives, the photonic band gaps of the MCPCPs blue-shifted correspondingly; this provided a novel stratagem for real-time self-reporting of the therapeutic agent release process of the MCPCPs. Hence, the MCPCPs are ideal for intelligent drug delivery because of these dramatical features.

Published
2018

22. Role of the MAPK/ERK pathway in valvular interstitial cell calcification

Author

Gu, Xiaoxiao and Masters, Kristyn S.

Subjects
Calcification -- Physiological aspects, Calcification -- Research, Cellular signal transduction -- Physiological aspects, Cellular signal transduction -- Research, Heart valve diseases -- Genetic aspects, Heart valve diseases -- Care and treatment, Heart valve diseases -- Research, Protein kinases -- Physiological aspects, Protein kinases -- Genetic aspects, Protein kinases -- Research, Biological sciences
Abstract

Much remains to be discovered about the etiology of heart valve disease and the molecular level mechanisms that drive it. The MAPK/ERK pathway influences calcification in many cell types and has been linked to the expression of a contractile phenotype in valvular interstitial cells (VICs). However, a direct correlation between MAPK/ERK pathway activity and VIC calcification has not been previously described. Thus the role of the MAPK pathway in the calcification of VIC cultures was investigated by measuring ERK activation in both calcifying and noncalcifying VIC environments and then, conversely, analyzing the effects of ERK pathway inhibition on VIC calcification and phenotype. Prolonged elevation of phosphorylated ERK-1/2 was found in calcifying VIC cultures, whereas directly blocking phosphorylation of ERK-1/2 resulted in a dramatic decrease in nodule number, nodule size, and total calcified area. Application of the ERK pathway inhibitor was also associated with a dramatic decrease in apoptosis, which may have contributed to the decreased nodule formation obtained via ERK inhibition. Real-time PCR analysis revealed that calcified samples exhibited significantly elevated expression of several myofibroblastic and osteoblastic markers, while ERK inhibition substantially reduced the expression of these markers, often to levels comparable to the noncalcifying control. These data suggest that the MAPK pathway plays an important role in regulating the phenotype and calcification of VICs, wherein sustained pathway activation is associated with increased VIC calcification. These findings may be used to further elucidate the mechanisms of valvular disease and identify potential treatment targets. heart valve; signaling pathways; extracellular matrix; mineralization

Published
2009

26. Sol-gel preparation and photoluminescence of size controlled germanium nanoparticles embedded in a SiO2 matrix

Author

Yang, Heqing, Yao, Xi, Wang, Xingjun, Xie, Songhai, and Fang, Yu; Liu, Shouxin; Gu, Xiaoxiao

Subjects
Hydrogen -- Influence, Hydrogen -- Chemical properties, Hydrogen -- Research, Germanium -- Research, Silica -- Research, Silica -- Chemical properties, Chemicals, plastics and rubber industries
Abstract

Germanium nanoparticles of different sizes in silica glasses are prepared via a sol-gel method, using Cl3-Ge-C2H4-COOH and Si (OC2H5)4 as the starting materials. It is observed that the size of the germanium nanoparticles decreases as the heat-treatment time in a H2 gas atmosphere increases, thus the optical absorption edge shifts to higher energies.

Published
2003

44. Abstract B10: Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in tuberous sclerosis complex

Author

Li, Chenggang, primary, Lee, Po-Shun, additional, Sun, Yang, additional, Zhang, Erik, additional, Gu, Xiaoxiao, additional, Li, Jing, additional, Xu, Kai-Feng, additional, Csibi, Alfredo, additional, Blenis, John, additional, Henske, Elizabeth Petri, additional, Levy, Bruce, additional, Kwiatkowski, David, additional, and Yu, Jane J., additional

Published
2015
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47. Abstract B09: Aspirin inhibits cyclooxygenase 2-mediated prostaglandin production and tumorigenesisin a preclinical model of tuberous sclerosis complex

Author

Li, Chenggang, primary, Lee, Po-Shun, additional, Sun, Yang, additional, Gu, Xiaoxiao, additional, Zhang, Erik, additional, Wu, Chin-Lee, additional, Parkhitko, Andrey, additional, Aurrichio, Neil, additional, Morrison, Tasha, additional, Blenis, John, additional, Xu, Kai-Feng, additional, Henske, Elizabeth Petri, additional, Levy, Bruce, additional, Kwiatkowski, David, additional, and Yu, Jane, additional

Published
2014
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48. Hybrid of gold nanostar and indocyanine green for targeted imaging-guided diagnosis and phototherapy using low-density laser irradiation.

Author

Gu, Xiaoxiao, Zhao, Wenjing, Liu, Zuojia, Li, Dan, Wang, Erkang, Du, Baoji, and Wang, Jin

Abstract

Phototherapy is widely studied with the development of photothermal nanomaterials. However, the laser power density for reaching effective phototherapy is still high and dangerous for normal tissues. In this research, based on multi-functional polydopamine, we proposed a general strategy to design diverse core–shell nanoparticles with different surface charges, and synthesized a targeted nanoplatform, AuNS@PDA–PEI–FA (APP), by coupling gold nanostar (AuNS) with polyethylenimine–folate (PEI–FA). Owing to the electrostatic interaction, the as-prepared APP can anchor a negatively-charged photosensitizer, indocyanine green (ICG), for photothermal and photodynamic synergistic cancer therapy. The APP–ICG is able to realize the targeted phototherapy for tumor cells even at the low power laser density of 0.33 W cm−2 both in vitro and in vivo. Furthermore, APP–ICG is not only a treatment nanoplatform but also a diagnosis agent. The integrative diagnosis results can be acquired by dual imaging technologies: the near-infrared fluorescence images and the photothermal images acquired by an in vivo imaging system and a thermal imaging camera, respectively. This new nanoplatform is a good diagnosis and treatment system and has the potential for further theranostics application. [ABSTRACT FROM AUTHOR]

Published
2016
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49. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells

Author

Li, Chenggang, primary, Lee, Po-Shun, additional, Sun, Yang, additional, Gu, Xiaoxiao, additional, Zhang, Erik, additional, Guo, Yanan, additional, Wu, Chin-Lee, additional, Auricchio, Neil, additional, Priolo, Carmen, additional, Li, Jing, additional, Csibi, Alfredo, additional, Parkhitko, Andrey, additional, Morrison, Tasha, additional, Planaguma, Anna, additional, Kazani, Shamsah, additional, Israel, Elliot, additional, Xu, Kai-Feng, additional, Henske, Elizabeth Petri, additional, Blenis, John, additional, Levy, Bruce D., additional, Kwiatkowski, David, additional, and Yu, Jane J., additional

Published
2014
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50. Abstract C59: Estradiol and mTORC2 orchestrate to enhance prostaglandin biosynthesis andtumorigenesis in tuberous sclerosis complex

Author

Li, Chenggang, primary, Lee, Po-Shun, additional, Gu, Xiaoxiao, additional, Sun, Yang, additional, Zhang, Erik, additional, Csibi, Alfredo, additional, Li, Jing, additional, Priolo, Carmen, additional, Guo, Yanan, additional, Wu, Chin-Lee, additional, Blenis, John, additional, Xu, Kai-Feng, additional, Henske, Elizabeth Petri, additional, Levy, Bruce, additional, Kwiatkowski, David, additional, and Yu, Jane J., additional

Published
2013
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