Search

Your search keyword '"Gu, Yixin"' showing total 163 results
Start Over Author "Gu, Yixin"
163 results on '"Gu, Yixin"'

13. Potential Targets and Signaling Mechanisms of Cinnamaldehyde Enhancing Intestinal Function and Nutritional Regulation in Fat Greenling (Hexagrammos otakii).

Author

Gu, Yixin, Zhan, Yu, Guo, Yafeng, Hua, Wenyuan, Qi, Xin, Gu, Zhizhi, Cao, Shengnan, Chen, Yan, Xue, Zhuang, and Wang, Wei

Subjects
*HEREDITY, *PROSTAGLANDIN receptors, *TRANSCRIPTION factors, *CHINESE medicine, *FAT, *MOLECULAR docking
Abstract

Cinnamaldehyde is an ideal feed additive with good immune enhancement and anti-inflammatory regulation effects. However, the anti-inflammatory regulation mechanism in fat greenling (Hexagrammos otakii, H. otakii) remains unclear. The nine targets of cinnamaldehyde were gathered in identified by the Traditional Chinese Medicine Systems Pharmacology database and Uniprot database, and 1,320 intestinal inflammation disease (IIF)-related proteins were screened from DrugBank, Online Mendelian Inheritance in Man (OMIM), Genecards, and Pharmacogenetics and Pharmacogenomics Knowledge Base (PHARMGKB) Databases. According to the Gene Ontology enrichment results and Kyoto Encyclopedia of Genes and Genomes pathway results, cinnamaldehyde may regulated the responses to bacteria, lipopolysaccharide, an inflammatory cytokine, and external stimuli via the nuclear factor kappa-B (NFκB) signaling pathway within on inflammatory network. In addition, the protein–protein interaction analysis assisted in obtaining the closely related inflammatory regulatory proteins, including the C5a anaphylatoxin chemotactic receptor 1 (C5aR1), transcription factor p65 (RELA), prostaglandin G/H synthase 2 (PTGS2), and toll-like receptor 4 (TLR4), which were confirmed as the bottleneck nodes of the network to be more deeply verified via the molecular docking. Moreover, a cinnamaldehyde feeding model was established for evaluating the anti-inflammatory effect of cinnamaldehyde in vivo. According to the current findings implied that cinnamaldehyde may play a protective role against IIF H. otakii by reducing inflammation through the C5 complement (C5)/C5aR1/interleukin-6 (IL-6) and TLR4/NFκB/PTGS2 pathway. The study focused on investigating the action mechanism of cinnamaldehyde on IIF through combining pharmacology and experimental verification in vivo, which provided a fresh perspective on the promoting effect of cinnamaldehyde on IIF in fish. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

30. Transmitted Sayings and Their Transmissibility: Patterns and Meanings of Zhuan yue 傳曰 Quotations in Early Chinese Texts.

Author

Gu, Yixin

Subjects
*QUOTATIONS, *CANON (Literature), *LITERARY criticism, *PATTERNMAKING, *LIBRARY storage centers
Abstract

This article investigates the introductory formula zhuan yue 傳曰 ("a transmitted source says") in early China, together with its "quotations" and their parallel texts. Rarely found in pre-imperial texts, the zhuan yue formula gained prominence especially from the mid-Western Han onward. As a vague, unspecific gesture of reference, the formula was flexibly applied to varying functions but also used with limited patterns and regularity. Both the formula and the quoted material are almost never found in the core texts of the "Five Classics" (wujing 五經); instead, zhuan yue appears to indicate sources that existed as an open repository outside of the emerging canon. Thus, in marking the non-canonical body, zhuan yue also helped define the canonical one. Finally, another usage of zhuan yue —which emerged in early Han times if not earlier—as an introduction to specific zhuan -commentaries of the classics is clearly a separate function altogether. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results