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Your search keyword '"Guan, Yi-chun"' showing total 14 results
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14 results on '"Guan, Yi-chun"'

4. BIN2 inhibition suppress ovarian cancer progression meanwhile protect ovarian function through downregulating HDAC1 and RPS6 phosphorylation respectively.

Author

Li, Cong‐Rong, Xie, Shi‐Ya, Zhang, Shu‐Ping, Yang, Yan‐Jie, Yang, Li‐Li, Cao, Ying, Wang, Li‐Li, Zhu, Feng‐Yu, Wang, Ruo‐Lei, Yang, Zhi‐Xia, Cui, Chen‐Chen, Li, Yan‐Ru, Xu, Jia‐Ning, Yue, Feng, Tian, Pei‐Zhe, Wang, Qian, Yao, Hong‐Jie, Guan, Yi‐Chun, Zhang, Shao‐Di, and Ying, Xiao‐Yan

Subjects
TUMOR suppressor genes, OVARIAN follicle, MEDICAL sciences, OVARIAN tumors, MERGERS & acquisitions
Abstract

The article explores the potential of BIN2 inhibition in suppressing ovarian cancer progression and protecting ovarian function. Through various experiments, it was found that BIN2 inhibition or knockout can suppress tumor growth, improve fertility, and protect ovarian health by targeting HDAC1 and RPS6. The study suggests a novel therapeutic strategy for young ovarian cancer patients by understanding the dual function of BIN2 in cancer progression and ovarian function. [Extracted from the article]

Published
2024
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7. The association between blastocyst quality during a single frozen-thawed blastocyst transfer cycle and subsequent perinatal outcomes: a propensity score-matched study

Author

Wu, Jing, primary, Yang, Chen, additional, Zheng, Wei, additional, Cao, Meng Yi, additional, Li, Meng Na, additional, Kuang, Yi Hui, additional, Ren, Bing Nan, additional, Ran, Shi Yu, additional, Zu, Ruo Wen, additional, Wu, Huan, additional, Shen, Ran, additional, Han, Jing Yi, additional, Li, Pei Xin, additional, and Guan, Yi Chun, additional

Published
2023
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9. Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation

Author

Chen, Liang-Jian, primary, Zhang, Na-Na, additional, Zhou, Chun-Xiang, additional, Yang, Zhi-Xia, additional, Li, Yan-Ru, additional, Zhang, Teng, additional, Li, Cong-Rong, additional, Wang, Xin, additional, Wang, Yang, additional, Wang, Zi-Bin, additional, Xia, Zheng-Rong, additional, Wang, Zhen-Bo, additional, Zhang, Cui-Lian, additional, Guan, Yi-Chun, additional, Sun, Qing-Yuan, additional, and Zhang, Dong, additional

Published
2021
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14. Influences of fresh and frozen embryo transfer on neonatal birthweight and the expression of imprinted genes PEG10/L3MBTL1in placenta

Author

Yang, Lu, Li, Zhe, Liu, Yang, Zhang, Jun-wei, Wang, Yun-xia, Hu, Ji-jun, Guan, Yi-chun, and Sun, Li-jun

Abstract

To investigate the influences of fresh embryo transfer (ET) and frozen embryo transfer (FET) on neonatal birthweight and the expression of imprinted genes PEG10and L3MBTL1in the placenta after in vitro fertilization-embryo transfer (IVF-ET), we analyzed the neonatal birthweight between fresh ET and FET transfer cycles. Then, we collected placentas delivered by fresh ET and FET, and real-time quantitative PCR, Western blotting and immunohistochemistry were used to detect the expression of PEG10and L3MBTL1. The mean neonatal birthweight of fresh ET was lower than that of FET(3348.48 ± 521.05 vs. 3450.34 ± 524.13, P <0.001). The risks of low birthweight (LBW) and small-for-gestational age (SGA) were lower after FET (3.9 % vs. 5.4 %; 7.2 % vs. 10.3 %), with adjusted rate ratios of 0.74 (95 % CI, 0.59–0.93; P = 0.003) and 0.70 (95 % CI, 0.59–0.84; P <0.001), respectively. FET resulted in higher frequencies of macrosomia and large-for-gestational age (LGA) (14.2 % vs. 10.3; 11.0 % vs. 7.1 %) than fresh ET, with adjusted rate ratios of 1.45 (95 % CI, 1.26–1.68; P <0.001) and 1.62 (95 % CI, 1.37–1.91; P <0.001), respectively. We also observed PEG10mRNA and protein expression levels in placentas delivered by fresh ET and FET were significantly different, but there were no significant differences in L3MBTL1between the two groups. Fresh ET may affect the expression of the imprinted gene PEG10in the placenta and adverse to placental implantation and development, resulting to increasing incidences of LBW and SGA.

Published
2022
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