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3 results on '"Guang-Ting He"'

1. IRE1α Signaling Pathways Involved in Mammalian Cell Fate Determination

Author

Jie Wu, Guang-Ting He, Wei-Jin Zhang, Jing Xu, and Qiao-Bing Huang

Subjects
Endoplasmic reticulum stress, Unfolded protein response, IRE1α, Apoptosis, Physiology, QP1-981, Biochemistry, QD415-436
Abstract

A diverse array of cellular stresses can lead to accumulation of misfolded or unfolded proteins in endoplasmic reticulum (ER), which subsequently elicits ER stress. Inositol-requiring enzyme 1α (IRE1α) is the most sensitive of the three unfolded protein response (UPR) branches which are triggered to cope with ER stress in mammalian cells. IRE1α signaling is quite context-specific on account of many adaptor and modulator proteins that directly interact with it, including heat shock proteins (HSPs), RING finger protein 13 (RNF13), poly (ADP-ribose) polymerase 16 (PARP16), Bax/Bak, and Bax inhibitor-1 (BI-1). The activated IRE1α triggers different downstream pathways depending on the UPRosome formed by distinct modulator proteins. At the initial phase of ER stress, IRE1α-XBP1 axis functions as an adaptive response. While ER stress sustains or intensifies, signals shift to apoptotic responses. Furthermore, IRE1α signaling can be exploited to the development of a wide range of prevalent human diseases, with cancer the most characterized. Here we provide an overview of recent insights into the complex IRE1α signaling network which makes IRE1α an intriguing cell fate switch. Besides, the functional relevance is presented since IRE1α activation also participates in some other physiological processes beyond protein-folding status.

Published
2016
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2. Apocynin protects endothelial cells from endoplasmic reticulum stress-induced apoptosis via IRE1α engagement

Author

Weijin Zhang, Jie Wu, Guang-Ting He, Peixin Li, Xiaohui Liu, Qiaobing Huang, Xiaohua Guo, Lili Wu, and Zhongqing Chen

Subjects
X-Box Binding Protein 1, inorganic chemicals, 0301 basic medicine, XBP1, RNA Splicing, Clinical Biochemistry, Apoptosis, Caspase 3, Protein Serine-Threonine Kinases, Apocynin, Article, 03 medical and health sciences, chemistry.chemical_compound, Endothelial cell, Endoribonucleases, Human Umbilical Vein Endothelial Cells, Humans, Molecular Biology, NADPH oxidase, biology, Chemistry, Endoplasmic reticulum, Acetophenones, IRE1α, Cell Biology, General Medicine, Endoplasmic Reticulum Stress, Cell biology, Endothelial stem cell, 030104 developmental biology, cardiovascular system, Unfolded protein response, biology.protein, circulatory and respiratory physiology
Abstract

Endoplasmic reticulum (ER) stress-induced endothelial cell (EC) apoptosis has been implicated in a variety of human diseases. In addition to being regarded as an NADPH oxidase (NOX) inhibitor, apocynin (APO) exhibits an anti-apoptotic effect in various cells. The present study aimed to identify the protective role of apocynin in ER stress-mediated EC apoptosis and the underlying mechanisms. We found that ER stress resulted in a significant increase in c-Jun N-terminal kinase phosphorylation, and elicited caspase 3 cleavage and apoptosis. However, apocynin obviously attenuated EC apoptosis and this effect was partly dependent on ER stress sensor inositol-requiring enzyme 1α (IRE1α). Importantly, apocynin upregulated IRE1α expression in both protein and mRNA levels and promoted the pro-survival XBP1 splicing. Our results suggest that apocynin protects ECs against ER stress-induced apoptosis via IRE1α involvement. These findings may provide a novel mechanistic explanation for the anti-apoptotic effect of apocynin in ER stress.

Published
2018

3. Multiple Change-Points Analysis for the Dependence Structures of Exchange Rate

Author

Jing Guan, Xia Cai, Xiu-min Li, and Guang-ting He

Subjects
Exchange rate, Gumbel distribution, business.industry, Generalized Pareto distribution, Economics, Econometrics, Portfolio, business, Extreme value theory, Eurodollar, Risk management, Copula (probability theory)
Abstract

Dependence plays an important role in risk management. Copula gradually becomes a useful tool for risk analysis because of its description of correlation of portfolio in finance. By using the Mixed Gumbel Copula and generalized Pareto distribution, an appropriate model is created to describe the dependence of two exchange rates - English Pound and Eurodollar. Then, the changes in dependence structure, which is modeled by using change-point techniques, are discussed. The results indicate that the change of dependence structure between these exchange return rates have close relations to some important finance events. This methodology is applied in many financial fields such as capital pricing and risk management.

Published
2009

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