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1. Bacterial-like inflammatory response in children with adenovirus leads to inappropriate antibiotic use: a multicenter cohort study

Author

Moracas, Cristina, Poeta, Marco, Grieco, Francesca, Tamborino, Agnese, Moriondo, Maria, Stracuzzi, Marta, Diana, Alfredo, Petrarca, Laura, Marra, Simona, Licari, Amelia, Linsalata, Stefano, Albano, Chiara, Condemi, Anna, Del Tufo, Ester, Di Fraia, Teresa, Punzi, Liana, Ardia, Eleonora, Lo Vecchio, Andrea, Bruzzese, Eugenia, Colomba, Claudia, Giacomet, Vania, Midulla, Fabio, Marseglia, Gian Luigi, Galli, Luisa, and Guarino, Alfredo

Published
2024
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2. Treatment of acute pharyngitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG)

Author

Chiappini, Elena, Simeone, Giovanni, Bergamini, Marcello, Pellegrino, Roberta, Guarino, Alfredo, Staiano, Annamaria, Esposito, Susanna, Gattinara, Guido Castelli, Vecchio, Andrea Lo, Stefani, Stefania, Iacono, Iride Dello, Scotese, Immacolata, Tezza, Giovanna, Dinardo, Giulio, Riccio, Simona, Pellizzari, Sofia, Iavarone, Sonia, Lorenzetti, Giulia, Venturini, Elisabetta, Donà, Daniele, Pierantoni, Luca, Doria, Mattia, Garazzino, Silvia, Midulla, Fabio, Cricelli, Claudio, Terracciano, Luigi, Capuano, Annalisa, Bruzzese, Eugenia, Ghiglioni, Daniele, Fusani, Lara, Fusco, Eleonora, Biasci, Paolo, Reggiani, Lamberto, Matera, Luigi, Mancino, Enrica, Barbieri, Elisa, D’Avino, Antonio, Cursi, Laura, Sullo, Maria Giuseppa, Scotti, Silvestro, Marseglia, Gian Luigi, Di Mauro, Giuseppe, Principi, Nicola, Galli, Luisa, and Verga, Maria Carmen

Published
2024
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3. Treatment of mild to moderate community-acquired pneumonia in previously healthy children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-FIMMG-SIMG)

Author

Donà, Daniele, Brigadoi, Giulia, Grandinetti, Roberto, Pedretti, Laura, Boscarino, Giovanni, Barbieri, Elisa, Matera, Luigi, Mancino, Enrica, Bergamini, Marcello, Castelli Gattinara, Guido, Chiappini, Elena, Doria, Mattia, Galli, Luisa, Guarino, Alfredo, Lo Vecchio, Andrea, Venturini, Elisabetta, Marseglia, Gianluigi, Verga, Maria Carmen, Di Mauro, Giuseppe, Principi, Nicola, Midulla, Fabio, and Esposito, Susanna

Published
2024
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4. Acute Infectious Diarrhea

Author

Poeta, Marco, Del Bene, Margherita, Lo Vecchio, Andrea, Guarino, Alfredo, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Guandalini, Stefano, editor, and Indrio, Flavia, editor

Published
2024
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5. Acute pharyngitis in children and adults: descriptive comparison of current recommendations from national and international guidelines and future perspectives

Author

Pellegrino, Roberta, Timitilli, Edoardo, Verga, Maria Carmen, Guarino, Alfredo, Iacono, Iride Dello, Scotese, Immacolata, Tezza, Giovanna, Dinardo, Giulio, Riccio, Simona, Pellizzari, Sofia, Iavarone, Sonia, Lorenzetti, Giulia, Simeone, Giovanni, Bergamini, Marcello, Donà, Daniele, Pierantoni, Luca, Garazzino, Silvia, Esposito, Susanna, Venturini, Elisabetta, Gattinara, Guido Castelli, Lo Vecchio, Andrea, Marseglia, Gian Luigi, Di Mauro, Giuseppe, Principi, Nicola, Galli, Luisa, and Chiappini, Elena

Published
2023
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8. Autoantibodies Against Proteins Previously Associated With Autoimmunity in Adult and Pediatric Patients With COVID-19 and Children With MIS-C

Author

Burbelo, Peter D, Castagnoli, Riccardo, Shimizu, Chisato, Delmonte, Ottavia M, Dobbs, Kerry, Discepolo, Valentina, Vecchio, Andrea Lo, Guarino, Alfredo, Licciardi, Francesco, Ramenghi, Ugo, Rey-Jurado, Emma, Vial, Cecilia, Marseglia, Gian Luigi, Licari, Amelia, Montagna, Daniela, Rossi, Camillo, Sanchez, Gina A Montealegre, Barron, Karyl, Warner, Blake M, Chiorini, John A, Espinosa, Yazmin, Noguera, Loreani, Dropulic, Lesia, Truong, Meng, Gerstbacher, Dana, Mató, Sayonara, Kanegaye, John, Tremoulet, Adriana H, Group, Pediatric Emergency Medicine Kawasaki, Eisenstein, Eli M, Su, Helen C, Imberti, Luisa, Poli, Maria Cecilia, Burns, Jane C, Notarangelo, Luigi D, Cohen, Jeffrey I, Abe, Naomi, Bryl, Amy, Donofrio-Odmann, J Joelle, Ekpenyong, Atim, Gardiner, Michael, Gutglass, David J, Nguyen, Margaret B, and Ulrich, Stacey

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Immunization, Pediatric, Coronaviruses, Emerging Infectious Diseases, Coronaviruses Disparities and At-Risk Populations, Clinical Research, Autoimmune Disease, Infectious Diseases, Health Disparities, Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Adaptor Proteins, Signal Transducing, Adenosine Triphosphatases, Adult, Autoantibodies, Autoantigens, Autoimmune Diseases, Autoimmunity, COVID-19, Child, Humans, Immunoglobulins, Intravenous, Lupus Erythematosus, Systemic, Ribonucleoproteins, Systemic Inflammatory Response Syndrome, autoantibodies, MIS-C multisystem inflammatory syndrome in children, IVIG, autoimmunity, Pediatric Emergency Medicine Kawasaki Group, Immunology, Medical Microbiology, Biochemistry and cell biology, Genetics
Abstract

The antibody profile against autoantigens previously associated with autoimmune diseases and other human proteins in patients with COVID-19 or multisystem inflammatory syndrome in children (MIS-C) remains poorly defined. Here we show that 30% of adults with COVID-19 had autoantibodies against the lung antigen KCNRG, and 34% had antibodies to the SLE-associated Smith-D3 protein. Children with COVID-19 rarely had autoantibodies; one of 59 children had GAD65 autoantibodies associated with acute onset of insulin-dependent diabetes. While autoantibodies associated with SLE/Sjögren's syndrome (Ro52, Ro60, and La) and/or autoimmune gastritis (gastric ATPase) were detected in 74% (40/54) of MIS-C patients, further analysis of these patients and of children with Kawasaki disease (KD), showed that the administration of intravenous immunoglobulin (IVIG) was largely responsible for detection of these autoantibodies in both groups of patients. Monitoring in vivo decay of the autoantibodies in MIS-C children showed that the IVIG-derived Ro52, Ro60, and La autoantibodies declined to undetectable levels by 45-60 days, but gastric ATPase autoantibodies declined more slowly requiring >100 days until undetectable. Further testing of IgG and/or IgA antibodies against a subset of potential targets identified by published autoantigen array studies of MIS-C failed to detect autoantibodies against most (16/18) of these proteins in patients with MIS-C who had not received IVIG. However, Troponin C2 and KLHL12 autoantibodies were detected in 2 of 20 and 1 of 20 patients with MIS-C, respectively. Overall, these results suggest that IVIG therapy may be a confounding factor in autoantibody measurements in MIS-C and that antibodies against antigens associated with autoimmune diseases or other human proteins are uncommon in MIS-C.

Published
2022

11. Correction to: Acute Infectious Diarrhea

Author

Poeta, Marco, Del Bene, Margherita, Lo Vecchio, Andrea, Guarino, Alfredo, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Guandalini, Stefano, editor, and Indrio, Flavia, editor

Published
2024
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12. Viral Diarrhea

Author

Guarino, Alfredo, Bruzzese, Eugenia, Guandalini, Stefano, editor, and Dhawan, Anil, editor

Published
2022
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14. Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies

Author

Poeta, Marco, primary, Moracas, Cristina, additional, Albano, Chiara, additional, Petrarca, Laura, additional, Maglione, Marco, additional, Pierri, Luca, additional, Carta, Maurizio, additional, Montaldo, Paolo, additional, Venturini, Elisabetta, additional, De Luca, Maia, additional, Buonsenso, Danilo, additional, Brambilla, Ilaria, additional, Giacomet, Vania, additional, Lo Vecchio, Andrea, additional, Bruzzese, Eugenia, additional, Midulla, Fabio, additional, Colomba, Claudia, additional, and Guarino, Alfredo, additional

Published
2024
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17. Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19

Author

Sacco, Keith, Castagnoli, Riccardo, Vakkilainen, Svetlana, Liu, Can, Delmonte, Ottavia M., Oguz, Cihan, Kaplan, Ian M., Alehashemi, Sara, Burbelo, Peter D., Bhuyan, Farzana, de Jesus, Adriana A., Dobbs, Kerry, Rosen, Lindsey B., Cheng, Aristine, Shaw, Elana, Vakkilainen, Mikko S., Pala, Francesca, Lack, Justin, Zhang, Yu, Fink, Danielle L., Oikonomou, Vasileios, Snow, Andrew L., Dalgard, Clifton L., Chen, Jinguo, Sellers, Brian A., Montealegre Sanchez, Gina A., Barron, Karyl, Rey-Jurado, Emma, Vial, Cecilia, Poli, Maria Cecilia, Licari, Amelia, Montagna, Daniela, Marseglia, Gian Luigi, Licciardi, Francesco, Ramenghi, Ugo, Discepolo, Valentina, Lo Vecchio, Andrea, Guarino, Alfredo, Eisenstein, Eli M., Imberti, Luisa, Sottini, Alessandra, Biondi, Andrea, Mató, Sayonara, Gerstbacher, Dana, Truong, Meng, Stack, Michael A., Magliocco, Mary, Bosticardo, Marita, Kawai, Tomoki, Danielson, Jeffrey J., Hulett, Tyler, Askenazi, Manor, Hu, Shaohui, Cohen, Jeffrey I., Su, Helen C., Kuhns, Douglas B., Lionakis, Michail S., Snyder, Thomas M., Holland, Steven M., Goldbach-Mansky, Raphaela, Tsang, John S., and Notarangelo, Luigi D.

Published
2022
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19. Italian intersociety consensus on management of long covid in children

Author

Esposito, Susanna, Principi, Nicola, Azzari, Chiara, Cardinale, Fabio, Di Mauro, Giuseppe, Galli, Luisa, Gattinara, Guido Castelli, Fainardi, Valentina, Guarino, Alfredo, Lancella, Laura, Licari, Amelia, Mancino, Enrica, Marseglia, Gian Luigi, Leonardi, Salvatore, Nenna, Raffaella, Zampogna, Stefania, Zona, Stefano, Staiano, Annamaria, and Midulla, Fabio

Published
2022
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20. Synbiotics in the Management of Pediatric Gastrointestinal Disorders: Position Paper of the ESPGHAN Special Interest Group on Gut Microbiota and Modifications

Author

Hojsak, Iva, Kolaček, Sanja, Mihatsch, Walter, Mosca, Alexis, Shamir, Raanan, Szajewska, Hania, Vandenplas, Yvan, van den Akker, Chris H. P., Berni Canani, Roberto, Dinleyici, Ener Cagri, Domellof, Magnus, van Goudoever, Johannes B., Guarino, Alfredo, Gutierrez-Castrellon, Pedro, Indrio, Flavia, Orel, Rok, Salvatore, Silvia, and Weizman, Zvi

Published
2023
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21. Reevaluating the FDA's warning against the use of probiotics in preterm neonates : a societal statement by ESPGHAN and EFCNI

Author

van den Akker, Chris H. P., Embleton, Nicholas D., Lapillonne, Alexandre, Mihatsch, Walter A., Salvatore, Silva, Canani, Roberto B., Dinleyici, Ener C., Domellöf, Magnus, Guarino, Alfredo, Gutiérrez-Castrellón, Pedro, Hojsak, Iva, Indrio, Flavia, Mosca, Alexis, Orel, Rok, van Goudoever, Johannes (Hans) B., Weizman, Zvi, Mader, Silke, Zimmermann, Luc J. I., Shamir, Raanan, Vandenplas, Yvan, Szajewska, Hania, van den Akker, Chris H. P., Embleton, Nicholas D., Lapillonne, Alexandre, Mihatsch, Walter A., Salvatore, Silva, Canani, Roberto B., Dinleyici, Ener C., Domellöf, Magnus, Guarino, Alfredo, Gutiérrez-Castrellón, Pedro, Hojsak, Iva, Indrio, Flavia, Mosca, Alexis, Orel, Rok, van Goudoever, Johannes (Hans) B., Weizman, Zvi, Mader, Silke, Zimmermann, Luc J. I., Shamir, Raanan, Vandenplas, Yvan, and Szajewska, Hania

Abstract

The recent advisory issued by the United States Food and Drug Administration, cautioning against the routine administration of probiotics in preterm neonates, has sparked a lively debate within the scientific community. This commentary presents a perspective from members of the Special Interest Group on Gut Microbiota and Modifications within the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and other authors who contributed to the ESPGHAN position paper on probiotics for preterm infants, as well as representatives from the European Foundation for the Care of Newborn Infants. We advocate for a more nuanced and supportive approach to the use of certain probiotics in this vulnerable population, balancing the demonstrated benefits and risks.

Published
2024
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22. Adolescent gender dysphoria management: position paper from the Italian Academy of Pediatrics, the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, the Italian Society of Adolescent Medicine and the Italian Society of Child and Adolescent Neuropsychiatry

Author

Calcaterra, V, Tornese, G, Zuccotti, G, Staiano, A, Cherubini, V, Gaudino, R, Fazzi, E, Barbi, E, Chiarelli, F, Corsello, G, Esposito, S, Ferrara, P, Iughetti, L, Laforgia, N, Maghnie, M, Marseglia, G, Perilongo, G, Pettoello-Mantovani, M, Ruggieri, M, Russo, G, Salerno, M, Striano, P, Valerio, G, Wasniewska, M, Agosti, M, Agostoni, C, Aiuti, A, Azzari, C, Badolato, R, Balduzzi, A, Baraldi, E, Canani, R, Biffi, A, Biondi, A, Bisogno, G, Pierri, N, Carnielli, V, Cianfarani, S, Cogo, P, Corvaglia, L, Dani, C, Di Salvo, G, Fagioli, F, Fanos, V, Ferrero, G, Francavilla, R, Galli, L, Gazzolo, D, Giaquinto, C, Giordano, P, Gitto, E, Grosso, S, Guarino, A, Indrio, F, Lanari, M, Lionetti, P, Locatelli, F, Lombardo, F, Maffeis, C, Marino, B, Midulla, F, Del Giudice, E, Del Giudice, M, Montini, G, Parenti, G, Parisi, P, Peroni, D, Perrotta, S, Piacentini, G, Pietrobelli, A, Raimondi, F, Ramenghi, U, Ravelli, A, Romano, C, Rossi, F, Rossi, P, Damiano, V, Spalice, A, Suppiej, A, Troncone, R, Verrotti, A, Null, N, Calcaterra, Valeria, Tornese, Gianluca, Zuccotti, Gianvincenzo, Staiano, Annamaria, Cherubini, Valentino, Gaudino, Rossella, Fazzi, Elisa Maria, Barbi, Egidio, Chiarelli, Francesco, Corsello, Giovanni, Esposito, Susanna Maria Roberta, Ferrara, Pietro, Iughetti, Lorenzo, Laforgia, Nicola, Maghnie, Mohamad, Marseglia, Gianluigi, Perilongo, Giorgio, Pettoello-Mantovani, Massimo, Ruggieri, Martino, Russo, Giovanna, Salerno, Mariacarolina, Striano, Pasquale, Valerio, Giuliana, Wasniewska, Malgorzata, Agosti, Massimo, Agostoni, Carlo Virginio, Aiuti, Alessandro, Azzari, Chiara, Badolato, Raffaele, Balduzzi, Adriana, Baraldi, Eugenio, Canani, Roberto Berni, Biffi, Alessandra, Biondi, Andrea, Bisogno, Gianni, Pierri, Nicola Brunetti, Carnielli, Virginio, Cianfarani, Stefano, Cogo, Paola, Corvaglia, Luigi, Dani, Carlo, Di Salvo, Giovanni, Fagioli, Franca, Fanos, Vassilios, Ferrero, Giovanni Battista, Francavilla, Ruggiero, Galli, Luisa, Gazzolo, Diego, Giaquinto, Carlo, Giordano, Paola, Gitto, Eloisa, Grosso, Salvatore, Guarino, Alfredo, Indrio, Flavia, Lanari, Marcello, Lionetti, Paolo, Locatelli, Franco, Lombardo, Fortunato, Maffeis, Claudio, Marino, Bruno, Midulla, Fabio, Del Giudice, Emanuele Miraglia, Del Giudice, Michele Miraglia, Montini, Giovanni, Parenti, Giancarlo, Parisi, Pasquale, Peroni, Diego, Perrotta, Silverio, Piacentini, Giorgio, Pietrobelli, Angelo, Raimondi, Francesco, Ramenghi, Ugo, Ravelli, Angelo, Romano, Claudio, Rossi, Francesca, Rossi, Paolo, Damiano, Vincenzo Salpietro, Spalice, Alberto, Suppiej, Agnese, Troncone, Riccardo, Verrotti, Alberto, null, null, Calcaterra, V, Tornese, G, Zuccotti, G, Staiano, A, Cherubini, V, Gaudino, R, Fazzi, E, Barbi, E, Chiarelli, F, Corsello, G, Esposito, S, Ferrara, P, Iughetti, L, Laforgia, N, Maghnie, M, Marseglia, G, Perilongo, G, Pettoello-Mantovani, M, Ruggieri, M, Russo, G, Salerno, M, Striano, P, Valerio, G, Wasniewska, M, Agosti, M, Agostoni, C, Aiuti, A, Azzari, C, Badolato, R, Balduzzi, A, Baraldi, E, Canani, R, Biffi, A, Biondi, A, Bisogno, G, Pierri, N, Carnielli, V, Cianfarani, S, Cogo, P, Corvaglia, L, Dani, C, Di Salvo, G, Fagioli, F, Fanos, V, Ferrero, G, Francavilla, R, Galli, L, Gazzolo, D, Giaquinto, C, Giordano, P, Gitto, E, Grosso, S, Guarino, A, Indrio, F, Lanari, M, Lionetti, P, Locatelli, F, Lombardo, F, Maffeis, C, Marino, B, Midulla, F, Del Giudice, E, Del Giudice, M, Montini, G, Parenti, G, Parisi, P, Peroni, D, Perrotta, S, Piacentini, G, Pietrobelli, A, Raimondi, F, Ramenghi, U, Ravelli, A, Romano, C, Rossi, F, Rossi, P, Damiano, V, Spalice, A, Suppiej, A, Troncone, R, Verrotti, A, Null, N, Calcaterra, Valeria, Tornese, Gianluca, Zuccotti, Gianvincenzo, Staiano, Annamaria, Cherubini, Valentino, Gaudino, Rossella, Fazzi, Elisa Maria, Barbi, Egidio, Chiarelli, Francesco, Corsello, Giovanni, Esposito, Susanna Maria Roberta, Ferrara, Pietro, Iughetti, Lorenzo, Laforgia, Nicola, Maghnie, Mohamad, Marseglia, Gianluigi, Perilongo, Giorgio, Pettoello-Mantovani, Massimo, Ruggieri, Martino, Russo, Giovanna, Salerno, Mariacarolina, Striano, Pasquale, Valerio, Giuliana, Wasniewska, Malgorzata, Agosti, Massimo, Agostoni, Carlo Virginio, Aiuti, Alessandro, Azzari, Chiara, Badolato, Raffaele, Balduzzi, Adriana, Baraldi, Eugenio, Canani, Roberto Berni, Biffi, Alessandra, Biondi, Andrea, Bisogno, Gianni, Pierri, Nicola Brunetti, Carnielli, Virginio, Cianfarani, Stefano, Cogo, Paola, Corvaglia, Luigi, Dani, Carlo, Di Salvo, Giovanni, Fagioli, Franca, Fanos, Vassilios, Ferrero, Giovanni Battista, Francavilla, Ruggiero, Galli, Luisa, Gazzolo, Diego, Giaquinto, Carlo, Giordano, Paola, Gitto, Eloisa, Grosso, Salvatore, Guarino, Alfredo, Indrio, Flavia, Lanari, Marcello, Lionetti, Paolo, Locatelli, Franco, Lombardo, Fortunato, Maffeis, Claudio, Marino, Bruno, Midulla, Fabio, Del Giudice, Emanuele Miraglia, Del Giudice, Michele Miraglia, Montini, Giovanni, Parenti, Giancarlo, Parisi, Pasquale, Peroni, Diego, Perrotta, Silverio, Piacentini, Giorgio, Pietrobelli, Angelo, Raimondi, Francesco, Ramenghi, Ugo, Ravelli, Angelo, Romano, Claudio, Rossi, Francesca, Rossi, Paolo, Damiano, Vincenzo Salpietro, Spalice, Alberto, Suppiej, Agnese, Troncone, Riccardo, Verrotti, Alberto, and null, null

Abstract

Background In response to the imperative need for standardized support for adolescent Gender Dysphoria (GD), the Italian Academy of Pediatrics, in collaboration with the Italian Society of Pediatrics, the Italian Society for Pediatric Endocrinology and Diabetes, Italian Society of Adolescent Medicine and Italian Society of Child and Adolescent Neuropsychiatry is drafting a position paper. The purpose of this paper is to convey the author's opinion on the topic, offering foundational information on potential aspects of gender-affirming care and emphasizing the care and protection of children and adolescents with GD.Main body Recognizing that adolescents may choose interventions based on their unique needs and goals and understanding that every individual within this group has a distinct trajectory, it is crucial to ensure that each one is welcomed and supported. The approach to managing individuals with GD is a multi-stage process involving a multidisciplinary team throughout all phases. Decisions regarding treatment should be reached collaboratively by healthcare professionals and the family, while considering the unique needs and circumstances of the individual and be guided by scientific evidence rather than biases or ideologies. Politicians and high court judges should address discrimination based on gender identity in legislation and support service development that aligns with the needs of young people. It is essential to establish accredited multidisciplinary centers equipped with the requisite skills and experience to effectively manage adolescents with GD, thereby ensuring the delivery of high-quality care.Conclusion Maintaining an evidence-based approach is essential to safeguard the well-being of transgender and gender diverse adolescents.

Published
2024

24. Acute Infectious Diarrhea

Author

Lo Vecchio, Andrea, Buccigrossi, Vittoria, Fedele, Maria Cristina, Guarino, Alfredo, Lambris, John D., Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Guandalini, Stefano, editor, and Indrio, Flavia, editor

Published
2019
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25. Prebiotics in the management of pediatric gastrointestinal disorders: Position paper of the ESPGHAN special interest group on gut microbiota and modifications

Author

Indrio, Flavia, primary, Dinleyici, Ener Cagri, additional, Berni Canani, Roberto, additional, Domellöf, Magnus, additional, Francavilla, Ruggiero, additional, Guarino, Alfredo, additional, Gutierrez Castrellon, Pedro, additional, Orel, Rok, additional, Salvatore, Silvia, additional, Van den Akker, Chris H. P., additional, and Weizman, Zvi, additional

Published
2024
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30. Training in Paediatric Clinical Nutrition Across Europe: A Survey of the National Societies Network (2016–2019) of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition

Author

Papadopoulou, Alexandra, Ribes-Koninckx, Carmen, Baker, Alastair, Noni, Maria, Koutri, Eleni, Karagianni, Maria-Vasiliki, Protheroe, Sue, Guarino, Alfredo, Mas, Emmanuel, Wilschanski, Michael, Roman, Enriqueta, Escher, Johanna, Furlano, Raoul I., Posovszky, Carsten, Hoffman, Ilse, Veres, Gabor, Bronsky, Jiri, Hauer, Almuthe Christine, Tjesic-Drinkovic, Duska, Fotoulaki, Maria, Orel, Rok, Urbonas, Vaidotas, Kansu, Aydan, Georgieva, Miglena, and Koletzko, Berthold

Published
2022
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31. Reevaluating the FDA's warning against the use of probiotics in preterm neonates: A societal statement by ESPGHAN and EFCNI

Author

Akker, Chris H. P., Embleton, Nicholas D., Lapillonne, Alexandre, Mihatsch, Walter A., Salvatore, Silva, Canani, Roberto B., Dinleyici, Ener C., Domellöf, Magnus, Guarino, Alfredo, Gutiérrez‐Castrellón, Pedro, Hojsak, Iva, Indrio, Flavia, Mosca, Alexis, Orel, Rok, Goudoever, Johannes (Hans) B., Weizman, Zvi, Mader, Silke, Zimmermann, Luc J. I., Shamir, Raanan, Vandenplas, Yvan, and Szajewska, Hania

Abstract

The recent advisory issued by the United States Food and Drug Administration, cautioning against the routine administration of probiotics in preterm neonates, has sparked a lively debate within the scientific community. This commentary presents a perspective from members of the Special Interest Group on Gut Microbiota and Modifications within the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) and other authors who contributed to the ESPGHAN position paper on probiotics for preterm infants, as well as representatives from the European Foundation for the Care of Newborn Infants. We advocate for a more nuanced and supportive approach to the use of certain probiotics in this vulnerable population, balancing the demonstrated benefits and risks.

Published
2024
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32. Dalbavancin for Acute Bacterial Skin and Skin Structure Infections in Pediatrics: Insights from Continuation Therapy Experience.

Author

Scarano, Sara Maria, Bruzzese, Eugenia, Poeta, Marco, Del Bene, Margherita, Guarino, Alfredo, and Lo Vecchio, Andrea

Subjects
SKIN infections, METHICILLIN-resistant staphylococcus aureus, SOFT tissue infections, PEDIATRIC therapy, INTRAVENOUS therapy
Abstract

Acute Bacterial Skin and Skin Structure Infections (ABSSSI) are marked by substantial morbidity, frequent need for hospitalization, and long courses of intravenous antibiotic therapy. Herein, we report four cases of pediatric patients admitted for ABSSSI and managed with a combination antibiotic regimen incorporating dalbavancin: a second-generation lipoglycopeptide active against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. In our experience, particularly in a setting with a high methicillin-resistance rate, dalbavancin demonstrated safety and efficacy, simplifying ABSSSI management in childhood. Its prolonged half-life enables a single-dose administration regimen, offering potential solutions to numerous challenges encountered in pediatric care, such as extended hospital stays, difficulties in securing and maintaining vascular access, lack of pediatric-specific drug indications, and limited availability of suitable oral formulations. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Aetiology, risk factors and microbiota composition in children with prolonged diarrhoea: A prospective case–controlled cohort study.

Author

Lo Vecchio, Andrea, Quitadamo, Paolo, Poeta, Marco, Buccigrossi, Vittoria, Siani, Paolo, Cioffi, Valentina, Ercolini, Danilo, and Guarino, Alfredo

Subjects
DIARRHEA, ETIOLOGY of diseases, INTESTINAL infections, COHORT analysis, BACTERIAL diseases
Abstract

Aim: Prolonged diarrhoea (ProD) refers to acute‐onset diarrhoea that persists for longer than 1 week. As the aetiology, risk factors and management are poorly defined, we prospectively enrolled children hospitalised in a high‐income setting to assess these outcomes and investigate the potential role of gut microbiota. Methods: All children aged 30 days to 14 years admitted for acute‐onset diarrhoea lasting 7–14 days were included. Children consecutively admitted in the same period for acute diarrhoea (AD) served as controls. High‐throughput sequencing of 16S rRNA gene amplicons was used to analyse stool samples from a subset of patients and healthy controls. Results: Sixty‐eight with ProD and 104 with AD were enrolled. Intestinal infections were the main aetiology of diarrhoea in both groups (ProD 92.9% vs. AD 97.8%). ProD children showed a higher prevalence of bacterial infections compared to AD (30.8% vs. 8.9%, p = 0.024). Neither age, host‐related factors, nor microbiome alterations were specifically linked to ProD. However, ProD children had a more severe initial clinical presentation than AD. Conclusion: ProD is often the result of an unusually severe intestinal infection that runs a course longer than expected but generally resolves without further problems. No specific management or therapies should be undertaken in most cases. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Lack of efficacy of Lactobacillus GG in reducing pulmonary exacerbations and hospital admissions in children with cystic fibrosis: A randomised placebo controlled trial

Author

Bruzzese, Eugenia, Raia, Valeria, Ruberto, Eliana, Scotto, Riccardo, Giannattasio, Antonietta, Bruzzese, Dario, Cavicchi, Maria Cristina, Francalanci, Michela, Colombo, Carla, Faelli, Nadia, Daccò, Valeria, Magazzù, Giuseppe, Costa, Stefano, Lucidi, Vincenzina, Majo, Fabio, and Guarino, Alfredo

Published
2018
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42. HIV and the Intestine

Author

Lo Vecchio, Andrea, Giannattasio, Antonietta, Guarino, Alfredo, Guandalini, Stefano, editor, Dhawan, Anil, editor, and Branski, David, editor

Published
2016
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43. Viral Diarrhea

Author

Guarino, Alfredo, Bruzzese, Eugenia, Guandalini, Stefano, editor, Dhawan, Anil, editor, and Branski, David, editor

Published
2016
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