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2. Evolution of a histone variant involved in compartmental regulation of NAD metabolism

Author

Guberovic, Iva, Hurtado-Bagès, Sarah, Rivera-Casas, Ciro, Knobloch, Gunnar, Malinverni, Roberto, Valero, Vanesa, Leger, Michelle M., García, Jesús, Basquin, Jerome, Gómez de Cedrón, Marta, Frigolé-Vivas, Marta, Cheema, Manjinder S., Pérez, Ainhoa, Ausió, Juan, Ramírez de Molina, Ana, Salvatella, Xavier, Ruiz-Trillo, Iñaki, Eirin-Lopez, Jose M., Ladurner, Andreas G., and Buschbeck, Marcus

Published
2021
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4. MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption

Author

Posavec Marjanović, Melanija, Hurtado-Bagès, Sarah, Lassi, Maximilian, Valero, Vanesa, Malinverni, Roberto, Delage, Hélène, Navarro, Miriam, Corujo, David, Guberovic, Iva, Douet, Julien, Gama-Perez, Pau, Garcia-Roves, Pablo M, Ahel, Ivan, Ladurner, Andreas G, Yanes, Oscar, Bouvet, Philippe, Suelves, Mònica, Teperino, Raffaele, Pospisilik, J Andrew, and Buschbeck, Marcus

Published
2017
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5. The 2021 FASEB science research conference on NAD metabolism and signaling

Author

Gorbunova, Vera, primary, Buschbeck, Marcus, additional, Cambronne, Xiaolu A., additional, Chellappa, Karthikeyani, additional, Corda, Daniela, additional, Du, Juan, additional, Freichel, Marc, additional, Gigas, Jonathan, additional, Green, Alexander E., additional, Gu, Feng, additional, Guberovic, Iva, additional, Jayabalan, Aravinthkumar, additional, Khansahib, Imrankhan, additional, Mukherjee, Sarmistha, additional, Seluanov, Andrei, additional, Simon, Matthew A., additional, Sverkeli, Lars J., additional, Kory, Nora, additional, Levine, Daniel C., additional, Matic, Ivan, additional, Nikiforov, Andrey, additional, Rack, Johannes G. M., additional, Imai, Shin-Ichiro, additional, Sinclair, David A., additional, Toiber, Debra, additional, Zhao, Yongjuan, additional, Mostoslavsky, Raul, additional, Kraus, Lee, additional, and Guse, Andreas H., additional

Published
2021
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6. Meeting Report The 2021 FASEB science research conference on NAD metabolism and signaling

Author

Gorbunova, Vera, Buschbeck, Marcus, Cambronne, Xiaolu A., Chellappa, Karthikeyani, Corda, Daniela, Du, Juan, Freichel, Marc, Gigas, Jonathan, Green, Alexander E., Gu, Feng, Guberovic, Iva, Jayabalan, Aravinthkumar, Khansahib, Imrankhan, Mukherjee, Sarmistha, Seluanov, Andrei, Simon, Matthew A., Sverkeli, Lars J., Kory, Nora, Levine, Daniel C., Ivan Matic, Nikiforov, Andrey, Rack, Johannes G. M., Imai, Shin-Ichiro, Sinclair, David A., Toiber, Debra, Zhao, Yongjuan, Mostoslavsky, Raul, Kraus, Lee, and Guse, Andreas H.

Subjects
aging, Correspondence Gorbunova, Sirtuins, NAD, signaling, Guse, metabolism, PARP
Published
2021

8. MacroH2A histone variants limit chromatin plasticity through two distinct mechanisms

Author

Kozlowski, Marek, primary, Corujo, David, additional, Hothorn, Michael, additional, Guberovic, Iva, additional, Mandemaker, Imke K, additional, Blessing, Charlotte, additional, Sporn, Judith, additional, Gutierrez‐Triana, Arturo, additional, Smith, Rebecca, additional, Portmann, Thomas, additional, Treier, Mathias, additional, Scheffzek, Klaus, additional, Huet, Sebastien, additional, Timinszky, Gyula, additional, Buschbeck, Marcus, additional, and Ladurner, Andreas G, additional

Published
2018
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10. MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD+consumption

Author

Marjanović, Melanija Posavec, Hurtado-Bagès, Sarah, Lassi, Maximilian, Valero, Vanesa, Malinverni, Roberto, Delage, Hélène, Navarro, Miriam, Corujo, David, Guberovic, Iva, Douet, Julien, Gama-Perez, Pau, Garcia-Roves, Pablo M, Ahel, Ivan, Ladurner, Andreas G, Yanes, Oscar, Bouvet, Philippe, Suelves, Mònica, Teperino, Raffaele, Pospisilik, J Andrew, and Buschbeck, Marcus

Abstract

Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A1.1 contains a macrodomain capable of binding NAD+-derived metabolites. Here we report that macroH2A1.1 is rapidly induced during myogenic differentiation through a switch in alternative splicing, and that myotubes that lack macroH2A1.1 have a defect in mitochondrial respiratory capacity. We found that the metabolite-binding macrodomain was essential for sustained optimal mitochondrial function but dispensable for gene regulation. Through direct binding, macroH2A1.1 inhibits basal poly-ADP ribose polymerase 1 (PARP-1) activity and thus reduces nuclear NAD+consumption. The resultant accumulation of the NAD+precursor NMN allows for maintenance of mitochondrial NAD+pools that are critical for respiration. Our data indicate that macroH2A1.1-containing chromatin regulates mitochondrial respiration by limiting nuclear NAD+consumption and establishing a buffer of NAD+precursors in differentiated cells.

Published
2017
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