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1. Lifetime smoking history and cohort-based smoking prevalence in chronic pancreatitis

Author

Jeon, Christie Y, Feldman, Robert, Althouse, Andrew, AlKaade, Samer, Brand, Randall E, Guda, Nalini, Sandhu, Bimaljit S, Singh, Vikesh K, Wilcox, C Mel, Slivka, Adam, Gelrud, Andres, Whitcomb, David C, and Yadav, Dhiraj

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Chronic Pain, Tobacco, Clinical Research, Substance Misuse, Pediatric, Cancer, Digestive Diseases, Pain Research, Tobacco Smoke and Health, Prevention, Respiratory, Chronic Pancreatitis, Epidemiology, Smoking, Cohort, Clinical Sciences, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background/objectiveSmoking prevalence in patients with chronic pancreatitis [CP] is high. We aimed to understand lifetime history of smoking and cohort trends in CP patients to inform effective strategies for smoking cessation.MethodData on 317 CP patients from the North American Pancreatitis Study 2 [NAPS2] Continuation and Validation Study and the NAPS2 Ancillary Study were analyzed. Smoking history was assessed for each phase of life from the onset of smoking to study enrollment. Data on second-hand smoke and drinking history were also collected. We compared demographic factors, drinking history, pain level and pancreas morphology by smoking status at age 25 (non-smoking,

Published
2021

2. Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression

Author

Bellin, Melena D., Beilman, Greg, Brand, Randall E., Shelton Ohlsen, Celeste, Saloman, Jami L., Whitcomb, David C., Park, H.J., Lee, Kenneth K., Paniccia, Alessandro, Zureikat, Amer, Alkaade, Samer, Amann, Stephen, Anderson, Michelle A., Banks, Peter, Conwell, Darwin L., Cote, Gregory A., Forsmark, Christopher E., Gardner, Timothy B., Gelrud, Andres, Guda, Nalini M., Lewis, Michele D., Muniraj, Thiruvengadam, Papachristou, Georgios I., Romagnuolo, Joseph, Sandhu, Bimaljit S., Sherman, Stuart, Singh, Vikesh K., Slivka, Adam, Melbern Wilcox, Charles, Yadav, Dhiraj, Fu, Dongni, Blobner, Brandon M., Greer, Phil J., and Lafyatis, Robert

Published
2023
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3. Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Author

AlKaade, Samer, Amann, Stephen T., Anderson, Michelle A., Banks, Peter, Conwell, Darwin, Brand, Randall E., Cote, Gregory A., Romagnuolo, Joseph, Forsmark, Christopher E., Gardner, Timothy, Gelrud, Andres, Guda, Nalini, Lewis, Michele, Muniraj, Thiruvengadam, Sandhu, Bimaljit S., Sherman, Stuart, Singh, Vikesh, Wilcox, C. Mel, Yadav, Dhiraj, Whitcomb, David C., Tang, Gong, Slivka, Adam, and Bellin, Melena

Published
2023
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4. Genetic Risk Score in Diabetes Associated With Chronic Pancreatitis Versus Type 2 Diabetes Mellitus

Author

Goodarzi, Mark O, Nagpal, Tanvi, Greer, Phil, Cui, Jinrui, Chen, Yii-Der I, Guo, Xiuqing, Pankow, James S, Rotter, Jerome I, Alkaade, Samer, Amann, Stephen T, Baillie, John, Banks, Peter A, Brand, Randall E, Conwell, Darwin L, Cote, Gregory A, Forsmark, Christopher E, Gardner, Timothy B, Gelrud, Andres, Guda, Nalini, LaRusch, Jessica, Lewis, Michele D, Money, Mary E, Muniraj, Thiruvengadam, Papachristou, Georgios I, Romagnuolo, Joseph, Sandhu, Bimaljit S, Sherman, Stuart, Singh, Vikesh K, Wilcox, C Mel, Pandol, Stephen J, Park, Walter G, Andersen, Dana K, Bellin, Melena D, Hart, Phil A, Yadav, Dhiraj, and Whitcomb, David C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Cardiovascular, Clinical Research, Diabetes, Genetics, Genetic Testing, Metabolic and endocrine, Aged, Case-Control Studies, Comorbidity, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Genotype, Humans, Male, Middle Aged, Pancreatitis, Chronic, Polymorphism, Single Nucleotide, Risk Factors, Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer, Clinical sciences
Abstract

IntroductionDiabetes mellitus (DM) is a complication of chronic pancreatitis (CP). Whether pancreatogenic diabetes associated with CP-DM represents a discrete pathophysiologic entity from type 2 DM (T2DM) remains uncertain. Addressing this question is needed for development of specific measures to manage CP-DM. We approached this question from a unique standpoint, hypothesizing that if CP-DM and T2DM are separate disorders, they should be genetically distinct. To test this hypothesis, we sought to determine whether a genetic risk score (GRS) based on validated single nucleotide polymorphisms for T2DM could distinguish between groups with CP-DM and T2DM.MethodsWe used 60 T2DM single nucleotide polymorphisms to construct a weighted GRS in 1,613 subjects from the North American Pancreatitis Study 2 and 2,685 subjects from the Multi-Ethnic Study of Atherosclerosis, all of European origin.ResultsThe mean GRS was identical between 321 subjects with CP-DM and 423 subjects with T2DM (66.53 vs 66.42, P = 0.95), and the GRS of both diabetic groups was significantly higher than that of nondiabetic controls (n = 3,554, P < 0.0001). Exploratory analyses attempting to enrich the CP-DM group for pancreatogenic diabetes, such as eliminating diabetes diagnosed before CP, requiring pancreas-specific comorbidities, or removing those with a family history of diabetes, did not improve the ability of the GRS to distinguish between CP-DM and T2DM.DiscussionRecognizing that we lacked a gold standard to define CP-DM, our study suggests that CP-DM may be a subtype of T2DM, a notion that should be tested in future, large prospective studies.

Published
2019

5. Chronic Pancreatitis

Author

Schwarzenberg, Sarah J, Uc, Aliye, Zimmerman, Bridget, Wilschanski, Michael, Wilcox, C Mel, Whitcomb, David C, Werlin, Steven L, Troendle, David, Tang, Gong, Slivka, Adam, Singh, Vikesh K, Sherman, Stuart, Shah, Uzma, Sandhu, Bimaljit S, Romagnuolo, Joseph, Rhee, Sue, Pohl, John F, Perito, Emily R, Ooi, Chee Y, Nathan, Jaimie D, Muniraj, Thiruvengadam, Morinville, Veronique D, McFerron, Brian, Mascarenhas, Maria, Maqbool, Asim, Liu, Quin, Lin, Tom K, Lewis, Michele, Husain, Sohail Z, Himes, Ryan, Heyman, Melvin B, Guda, Nalini, Gonska, Tanja, Giefer, Matthew J, Gelrud, Andres, Gariepy, Cheryl E, Gardner, Timothy B, Freedman, Steven D, Forsmark, Christopher E, Fishman, Douglas S, Cote, Gregory A, Conwell, Darwin, Brand, Randall E, Bellin, Melena, Barth, Bradley, Banks, Peter A, Anderson, Michelle A, Amann, Stephen T, Alkaade, Samer, Abu-El-Haija, Maisam, Abberbock, Judah N, Lowe, Mark E, and Yadav, Dhiraj

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Digestive Diseases, Prevention, Pediatric, 2.1 Biological and endogenous factors, Aetiology, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Oral and gastrointestinal, Good Health and Well Being, Adolescent, Adult, Alcohol Drinking, Child, Cohort Studies, Cross-Sectional Studies, Demography, Disease Progression, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, North America, Pancreatitis, Chronic, Risk Factors, Socioeconomic Factors, Surveys and Questionnaires, Tobacco Smoking, children, diabetes, endoscopy, environmental, genetic, pain, Medical and Health Sciences, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics, Paediatrics
Abstract

ObjectivesThe aim of the present study was to investigate the natural history of chronic pancreatitis (CP); patients in the North American Pancreatitis Study2 (NAPS2, adults) and INternational Study group of Pediatric Pancreatitis: In search for a cuRE (INSPPIRE, pediatric) were compared.MethodsDemographics, risk factors, disease duration, management and outcomes of 224 children and 1063 adults were compared using appropriate statistical tests for categorical and continuous variables.ResultsAlcohol was a risk in 53% of adults and 1% of children (P

Published
2019

6. Competence in Endoscopic Ultrasound and Endoscopic Retrograde Cholangiopancreatography, From Training Through Independent Practice

Author

Wani, Sachin, Keswani, Rajesh N, Han, Samuel, Aagaard, Eva M, Hall, Matthew, Simon, Violette, Abidi, Wasif M, Banerjee, Subhas, Baron, Todd H, Bartel, Michael, Bowman, Erik, Brauer, Brian C, Buscaglia, Jonathan M, Carlin, Linda, Chak, Amitabh, Chatrath, Hemant, Choudhary, Abhishek, Confer, Bradley, Coté, Gregory A, Das, Koushik K, DiMaio, Christopher J, Dries, Andrew M, Edmundowicz, Steven A, El Chafic, Abdul Hamid, El Hajj, Ihab, Ellert, Swan, Ferreira, Jason, Gamboa, Anthony, Gan, Ian S, Gangarosa, Lisa M, Gannavarapu, Bhargava, Gordon, Stuart R, Guda, Nalini M, Hammad, Hazem T, Harris, Cynthia, Jalaj, Sujai, Jowell, Paul S, Kenshil, Sana, Klapman, Jason, Kochman, Michael L, Komanduri, Srinadh, Lang, Gabriel, Lee, Linda S, Loren, David E, Lukens, Frank J, Mullady, Daniel, Muthusamy, V Raman, Nett, Andrew S, Olyaee, Mojtaba S, Pakseresht, Kavous, Perera, Pranith, Pfau, Patrick, Piraka, Cyrus, Poneros, John M, Rastogi, Amit, Razzak, Anthony, Riff, Brian, Saligram, Shreyas, Scheiman, James M, Schuster, Isaiah, Shah, Raj J, Sharma, Rishi, Spaete, Joshua P, Singh, Ajaypal, Sohail, Muhammad, Sreenarasimhaiah, Jayaprakash, Stevens, Tyler, Tabibian, James H, Tzimas, Demetrios, Uppal, Dushant S, Urayama, Shiro, Vitterbo, Domenico, Wang, Andrew Y, Wassef, Wahid, Yachimski, Patrick, Zepeda-Gomez, Sergio, Zuchelli, Tobias, and Early, Dayna

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Clinical Research, Digestive Diseases, Cholangiopancreatography, Endoscopic Retrograde, Clinical Competence, Endosonography, Humans, Learning Curve, Prospective Studies, Quality Indicators, Health Care, Quality Indicators, Advanced Endoscopy Training, Learning Curves, The EUS and ERCP Skills Assessment Tool, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Abstract

Background & aimsIt is unclear whether participation in competency-based fellowship programs for endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) results in high-quality care in independent practice. We measured quality indicator (QI) adherence during the first year of independent practice among physicians who completed endoscopic training with a systematic assessment of competence.MethodsWe performed a prospective multicenter cohort study of invited participants from 62 training programs. In phase 1, 24 advanced endoscopy trainees (AETs), from 20 programs, were assessed using a validated competence assessment tool. We used a comprehensive data collection and reporting system to create learning curves using cumulative sum analysis that were shared with AETs and trainers quarterly. In phase 2, participating AETs entered data into a database pertaining to every EUS and ERCP examination during their first year of independent practice, anchored by key QIs.ResultsBy the end of training, most AETs had achieved overall technical competence (EUS 91.7%, ERCP 73.9%) and cognitive competence (EUS 91.7%, ERCP 94.1%). In phase 2 of the study, 22 AETs (91.6%) participated and completed a median of 136 EUS examinations per AET and 116 ERCP examinations per AET. Most AETs met the performance thresholds for QIs in EUS (including 94.4% diagnostic rate of adequate samples and 83.8% diagnostic yield of malignancy in pancreatic masses) and ERCP (94.9% overall cannulation rate).ConclusionsIn this prospective multicenter study, we found that although competence cannot be confirmed for all AETs at the end of training, most meet QI thresholds for EUS and ERCP at the end of their first year of independent practice. This finding affirms the effectiveness of training programs. Clinicaltrials.gov ID NCT02509416.

Published
2018

7. Differences in Age at Onset of Symptoms, and Effects of Genetic Variants, in Patients With Early vs Late-Onset Idiopathic Chronic Pancreatitis in a North American Cohort

Author

Lewis, Michele D., Talluri, Jyothsna, Wilcox, C. Mel, Abberbock, Judah N., Tang, Gong, Conwell, Darwin L., Banks, Peter A., Cote, Gregory A., Sherman, Stuart, Alkaade, Samer, Gardner, Timothy B., Anderson, Michelle A., Sandhu, Bimaljit S., Muniraj, Thiruvengadam, Forsmark, Chris E., Guda, Nalini, Gelrud, Andres, Romagnuolo, Joseph, Brand, Randall, LaRusch, Jessica, Amann, Stephen T., Slivka, Adam, Whitcomb, David C., and Yadav, Dhiraj

Published
2021
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9. Rectal indometacin dose escalation for prevention of pancreatitis after endoscopic retrograde cholangiopancreatography in high-risk patients: a double-blind, randomised controlled trial

Author

Fogel, Evan L, Lehman, Glen A, Tarnasky, Paul, Cote, Gregory A, Schmidt, Suzette E, Waljee, Akbar K, Higgins, Peter D R, Watkins, James L, Sherman, Stuart, Kwon, Richard S Y, Elta, Grace H, Easler, Jeffrey J, Pleskow, Douglas K, Scheiman, James M, El Hajj, Ihab I, Guda, Nalini M, Gromski, Mark A, McHenry, Lee, Jr, Arol, Seena, Korsnes, Sheryl, Suarez, Alejandro L, Spitzer, Rebecca, Miller, Marilyn, Hofbauer, Maria, and Elmunzer, B Joseph

Published
2020
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10. Increased awareness enhances physician recognition of the role of smoking in chronic pancreatitis

Author

Muniraj, Thiruvengadam, Yadav, Dhiraj, Abberbock, Judah N., Alkaade, Samer, Amann, Stephen T., Anderson, Michelle A., Banks, Peter A., Brand, Randall E., Conwell, Darwin, Cote, Gregory A., Forsmark, Christopher E., Gardner, Timothy B., Gelrud, Andres, Guda, Nalini, Lewis, Michele D., Romagnuolo, Joseph, Sandhu, Bimaljit S., Sherman, Stuart, Singh, Vikesh K., Slivka, Adam, Tang, Gong, Whitcomb, David C., and Wilcox, C. Mel

Published
2019
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11. Setting minimum standards for training in EUS and ERCP: results from a prospective multicenter study evaluating learning curves and competence among advanced endoscopy trainees

Author

Wani, Sachin, Han, Samuel, Simon, Violette, Hall, Matthew, Early, Dayna, Aagaard, Eva, Abidi, Wasif M., Banerjee, Subhas, Baron, Todd H., Bartel, Michael, Bowman, Erik, Brauer, Brian C., Buscaglia, Jonathan M., Carlin, Linda, Chak, Amitabh, Chatrath, Hemant, Choudhary, Abhishek, Confer, Bradley, Coté, Gregory A., Das, Koushik K., DiMaio, Christopher J., Dries, Andrew M., Edmundowicz, Steven A., El Chafic, Abdul Hamid, El Hajj, Ihab, Ellert, Swan, Ferreira, Jason, Gamboa, Anthony, Gan, Ian S., Gangarosa, Lisa, Gannavarapu, Bhargava, Gordon, Stuart R., Guda, Nalini M., Hammad, Hazem T., Harris, Cynthia, Jalaj, Sujai, Jowell, Paul, Kenshil, Sana, Klapman, Jason, Kochman, Michael L., Komanduri, Sri, Lang, Gabriel, Lee, Linda S., Loren, David E., Lukens, Frank J., Mullady, Daniel, Muthusamy, Raman V., Nett, Andrew S., Olyaee, Mojtaba S., Pakseresht, Kavous, Perera, Pranith, Pfau, Patrick, Piraka, Cyrus, Poneros, John M., Rastogi, Amit, Razzak, Anthony, Riff, Brian, Saligram, Shreyas, Scheiman, James M., Schuster, Isaiah, Shah, Raj J., Sharma, Rishi, Spaete, Joshua P., Singh, Ajaypal, Sohail, Muhammad, Sreenarasimhaiah, Jayaprakash, Stevens, Tyler, Tabibian, James H., Tzimas, Demetrios, Uppal, Dushant S., Urayama, Shiro, Vitterbo, Domenico, Wang, Andrew Y., Wassef, Wahid, Yachimski, Patrick, Zepeda-Gomez, Sergio, Zuchelli, Tobias, and Keswani, Rajesh N.

Published
2019
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13. Known genetic susceptibility factors for chronic pancreatitis in patients of European ancestry are rare in patients of African ancestry

Author

Phillips, Anna Evans, LaRusch, Jessica, Greer, Phil, Abberbock, Judah, Alkaade, Samer, Amann, Stephen T., Anderson, Michelle A., Baillie, John, Banks, Peter A., Brand, Randall E., Conwell, Darwin, Coté, Gregory A., Forsmark, Christopher E., Gardner, Timothy B., Gelrud, Andres, Guda, Nalini, Lewis, Michele, Money, Mary E., Muniraj, Thiruvengadam, Sandhu, Bimaljit S., Sherman, Stuart, Singh, Vikesh K., Slivka, Adam, Tang, Gong, Wilcox, C. Mel, Whitcomb, David C., and Yadav, Dhiraj

Published
2018
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14. ASGE guideline for infection control during GI endoscopy

Author

Calderwood, Audrey H., Day, Lukejohn W., Muthusamy, V. Raman, Collins, James, Hambrick, Ralph David, III, Brock, Andrew S., Guda, Nalini M., Buscaglia, Jonathan M., Petersen, Bret T., Buttar, Navtej S., Khanna, Lauren G., Kushnir, Vladimir M., Repaka, Aparna, Villa, Nicolas A., and Eisen, Glenn M.

Published
2018
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15. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

Author

Whitcomb, David C, LaRusch, Jessica, Krasinskas, Alyssa M, Klei, Lambertus, Smith, Jill P, Brand, Randall E, Neoptolemos, John P, Lerch, Markus M, Tector, Matt, Sandhu, Bimaljit S, Guda, Nalini M, Orlichenko, Lidiya, Alkaade, Samer, Amann, Stephen T, Anderson, Michelle A, Baillie, John, Banks, Peter A, Conwell, Darwin, Coté, Gregory A, Cotton, Peter B, DiSario, James, Farrer, Lindsay A, Forsmark, Chris E, Johnstone, Marianne, Gardner, Timothy B, Gelrud, Andres, Greenhalf, William, Haines, Jonathan L, Hartman, Douglas J, Hawes, Robert A, Lawrence, Christopher, Lewis, Michele, Mayerle, Julia, Mayeux, Richard, Melhem, Nadine M, Money, Mary E, Muniraj, Thiruvengadam, Papachristou, Georgios I, Pericak-Vance, Margaret A, Romagnuolo, Joseph, Schellenberg, Gerard D, Sherman, Stuart, Simon, Peter, Singh, Vijay P, Slivka, Adam, Stolz, Donna, Sutton, Robert, Weiss, Frank Ulrich, Wilcox, C Mel, Zarnescu, Narcis Octavian, Wisniewski, Stephen R, O'Connell, Michael R, Kienholz, Michelle L, Roeder, Kathryn, Barmada, M Michael, Yadav, Dhiraj, and Devlin, Bernie

Subjects
Biological Sciences, Genetics, Clinical Research, Human Genome, Substance Misuse, Digestive Diseases, Alcoholism, Alcohol Use and Health, Prevention, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Good Health and Well Being, Claudins, Female, Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Genome-Wide Association Study, Homozygote, Humans, Male, Mutation, Pancreatitis, Alcoholic, Sex Factors, Trypsin, Trypsinogen, Alzheimer's Disease Genetics Consortium, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 (P < 1 × 10(-12)) and X-linked CLDN2 (P < 1 × 10(-21)) through a two-stage genome-wide study (stage 1: 676 cases and 4,507 controls; stage 2: 910 cases and 4,170 controls). The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous (or hemizygous in males) CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men (male hemizygote frequency is 0.26, whereas female homozygote frequency is 0.07).

Published
2012

16. DEVELOPMENT OF AMERICAN SOCIETY FOR GASTROINTESTINAL ENDOSCOPY (ASGE) MINIMUM STANDARDS FOR TRAINING IN INTERVENTIONAL ENDOSCOPY WITHIN DEDICATED INTERVENTIONAL ENDOSCOPY FELLOWSHIP PROGRAMS

Author

Wani, Sachin, primary, Cote, Gregory, additional, Keswani, Rajesh, additional, Yadlapati, Rena, additional, Hall, Matt, additional, O'Hara, Jack, additional, Berzin, Tyler, additional, Burbridge, Rebecca, additional, Chahal, Prabhleen, additional, Cohen, Jonathan, additional, Coyle, Walter, additional, Early, Dayna, additional, Guda, Nalini, additional, Inamdar, Sumant, additional, Khanna, Lauren, additional, Kulkarni, Abhijit, additional, Rosenkranz, Laura, additional, Sharma, Neil, additional, Shin, Eun, additional, Siddiqui, Uzma, additional, Sinha, Jasmine, additional, Vanderveldt, Hendrikus, additional, and Draganov, Peter, additional

Published
2023
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21. Recurrent Acute Pancreatitis Significantly Reduces Quality of Life Even in the Absence of Overt Chronic Pancreatitis

Author

Coté, Gregory A., Yadav, Dhiraj, Abberbock, Judah A., Whitcomb, David C., Sherman, Stuart, Sandhu, Bimaljit S., Anderson, Michelle A., Lewis, Michele D., Alkaade, Samer, Singh, Vikesh K., Baillie, John, Banks, Peter A., Conwell, Darwin, Guda, Nalini M., Muniraj, Thiruvengadam, Tang, Gong, Brand, Randall, Gelrud, Andres, Amann, Stephen T., Forsmark, Christopher E., Wilcox, C. Mel, Slivka, Adam, and Gardner, Timothy B.

Published
2018
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22. Mechanism, assessment and management of pain in chronic pancreatitis: Recommendations of a multidisciplinary study group

Author

Anderson, Michelle A., Akshintala, Venkata, Albers, Kathryn M., Amann, Stephen T., Belfer, Inna, Brand, Randall, Chari, Suresh, Cote, Greg, Davis, Brian M., Frulloni, Luca, Gelrud, Andres, Guda, Nalini, Humar, Abhinav, Liddle, Rodger A., Slivka, Adam, Gupta, Rachelle Stopczynski, Szigethy, Eva, Talluri, Jyothsna, Wassef, Wahid, Wilcox, C. Mel, Windsor, John, Yadav, Dhiraj, and Whitcomb, David C.

Published
2016
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23. Chronic Pancreatitis: Pediatric and Adult Cohorts Show Similarities in Disease Progress Despite Different Risk Factors

Author

Schwarzenberg, Sarah J., Uc, Aliye, Zimmerman, Bridget, Wilschanski, Michael, Wilcox, C. Mel, Whitcomb, David C., Werlin, Steven L., Troendle, David, Tang, Gong, Slivka, Adam, Singh, Vikesh K., Sherman, Stuart, Shah, Uzma, Sandhu, Bimaljit S., Romagnuolo, Joseph, Rhee, Sue, Pohl, John F., Perito, Emily R., Ooi, Chee Y., Nathan, Jaimie D., Muniraj, Thiruvengadam, Morinville, Veronique D., McFerron, Brian, Mascarenhas, Maria, Maqbool, Asim, Liu, Quin, Lin, Tom K., Lewis, Michele, Husain, Sohail Z., Himes, Ryan, Heyman, Melvin B., Guda, Nalini, Gonska, Tanja, Giefer, Matthew J., Gelrud, Andres, Gariepy, Cheryl E., Gardner, Timothy B., Freedman, Steven D., Forsmark, Christopher E., Fishman, Douglas S., Cote, Gregory A., Conwell, Darwin, Brand, Randall E., Bellin, Melena, Barth, Bradley, Banks, Peter A., Anderson, Michelle A., Amann, Stephen T., Alkaade, Samer, Abu-El-Haija, Maisam, Abberbock, Judah N., Lowe, Mark E., and Yadav, Dhiraj

Published
2019
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24. Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression

Author

Fu, Dongni, primary, Blobner, Brandon M., additional, Greer, Phil J., additional, Lafyatis, Robert, additional, Bellin, Melena D., additional, Whitcomb, David C., additional, Beilman, Greg, additional, Brand, Randall E., additional, Shelton Ohlsen, Celeste, additional, Saloman, Jami L., additional, Park, H.J., additional, Lee, Kenneth K., additional, Paniccia, Alessandro, additional, Zureikat, Amer, additional, Alkaade, Samer, additional, Amann, Stephen, additional, Anderson, Michelle A., additional, Banks, Peter, additional, Conwell, Darwin L., additional, Cote, Gregory A., additional, Forsmark, Christopher E., additional, Gardner, Timothy B., additional, Gelrud, Andres, additional, Guda, Nalini M., additional, Lewis, Michele D., additional, Muniraj, Thiruvengadam, additional, Papachristou, Georgios I., additional, Romagnuolo, Joseph, additional, Sandhu, Bimaljit S., additional, Sherman, Stuart, additional, Singh, Vikesh K., additional, Slivka, Adam, additional, Melbern Wilcox, Charles, additional, and Yadav, Dhiraj, additional

Published
2023
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25. Autoimmunity May Explain Diabetes in a Subset of Patients With Recurrent Acute and Chronic Pancreatitis: A Pilot Study

Author

Yadav, Dhiraj, primary, Whitcomb, David C., additional, Tang, Gong, additional, Slivka, Adam, additional, Bellin, Melena, additional, AlKaade, Samer, additional, Amann, Stephen T., additional, Anderson, Michelle A., additional, Banks, Peter, additional, Conwell, Darwin, additional, Brand, Randall E., additional, Cote, Gregory A., additional, Romagnuolo, Joseph, additional, Forsmark, Christopher E., additional, Gardner, Timothy, additional, Gelrud, Andres, additional, Guda, Nalini, additional, Lewis, Michele, additional, Muniraj, Thiruvengadam, additional, Sandhu, Bimaljit S., additional, Sherman, Stuart, additional, Singh, Vikesh, additional, and Wilcox, C. Mel, additional

Published
2023
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26. Chronic Pancreatitis Pain Pattern and Severity Are Independent of Abdominal Imaging Findings

Author

Wilcox, C. Mel, Yadav, Dhiraj, Ye, Tian, Gardner, Timothy B., Gelrud, Andres, Sandhu, Bimaljit S., Lewis, Michele D., Al-Kaade, Samer, Cote, Gregory A., Forsmark, Christopher E., Guda, Nalini M., Conwell, Darwin L., Banks, Peter A., Muniraj, Thiruvengadam, Romagnuolo, Joseph, Brand, Randall E., Slivka, Adam, Sherman, Stuart, Wisniewski, Stephen R., Whitcomb, David C., and Anderson, Michelle A.

Published
2015
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28. Acute pancreatitis precedes chronic pancreatitis in the majority of patients: Results from the NAPS2 consortium

Author

Singh, Vikesh K., primary, Whitcomb, David C., additional, Banks, Peter A., additional, AlKaade, Samer, additional, Anderson, Michelle A., additional, Amann, Stephen T., additional, Brand, Randall E., additional, Conwell, Darwin L., additional, Cote, Gregory A., additional, Gardner, Timothy B., additional, Gelrud, Andres, additional, Guda, Nalini, additional, Forsmark, Christopher E., additional, Lewis, Michele, additional, Sherman, Stuart, additional, Muniraj, Thiruvengadam, additional, Romagnuolo, Joseph, additional, Tan, Xiaoqing, additional, Tang, Gong, additional, Sandhu, Bimaljit S., additional, Slivka, Adam, additional, Wilcox, C. Mel, additional, Yadav, Dhiraj, additional, Banks, Peter, additional, Conwell, Darwin, additional, Lo, Simon K., additional, Gardner, Timothy, additional, Baillie, John, additional, Singh, Vikesh K., additional, Hawes, Robert, additional, Lawrence, Christopher, additional, Etemad, Babak, additional, DeMeo, Mark, additional, Kochman, Michael, additional, Abberbock, Judah N., additional, Barmada, M. Michael, additional, Bauer, Emil, additional, Kennard, Elizabeth, additional, LaRusch, Jessica, additional, O'Connell, Michael, additional, Stello, Kimberly, additional, Talluri, Jyothsna, additional, Wisniewski, Stephen R., additional, Burton, Frank, additional, DiSario, James, additional, Money, Mary, additional, and Steinberg, William, additional

Published
2022
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29. Validation of Demographics, Etiology, and Risk Factors for Chronic Pancreatitis in the USA: A Report of the North American Pancreas Study (NAPS) Group

Author

Conwell, Darwin L., Banks, Peter A., Sandhu, Bimaljit S., Sherman, Stuart, Al-Kaade, Samer, Gardner, Timothy B., Anderson, Michelle A., Wilcox, C. Mel, Lewis, Michele D., Muniraj, Thiruvengadam, Forsmark, Christopher E., Cote, Gregory A., Guda, Nalini M., Tian, Ye, Romagnuolo, Joseph, Wisniewski, Stephen R., Brand, Randall, Gelrud, Andres, Slivka, Adam, Whitcomb, David C., and Yadav, Dhiraj

Published
2017
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31. Recurrent Acute Pancreatitis: International State-of-the-Science Conference With Recommendations

Author

Guda, Nalini M., Muddana, Venkata, Whitcomb, David C., Levy, Philippe, Garg, Pramod, Cote, Gregory, Uc, Aliye, Varadarajulu, Shyam, Vege, Santhi S., Chari, Suresh T., Forsmark, Chris E., Yadav, Dhiraj, Reddy, D. Nageshwar, Tenner, Scott, Johnson, Colin D., Akisik, Fatih, Saluja, Ashok K., Lerch, Markus M., Mallery, J. Shawn, and Freeman, Martin L.

Published
2018
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34. Do Nontechnical Skills Affect Legal Outcomes After Endoscopic Perforations?

Author

Guda Nalini, Lauren D. Feld, Dominic Klyve, Lyndon V. Hernandez, and Andrew D. Feld

Subjects
medicine.medical_specialty, media_common.quotation_subject, Indemnity, Odds, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Registries, media_common, Physician-Patient Relations, Medical Errors, Hepatology, business.industry, Communication, Medical record, Gastroenterologists, Malpractice, Gastroenterology, Endoscopy, Odds ratio, Payment, Confidence interval, 030220 oncology & carcinogenesis, Family medicine, 030211 gastroenterology & hepatology, Observational study, Clinical Competence, business, Allegation
Abstract

INTRODUCTION Health systems often emphasize technical skills to reduce iatrogenic injuries. Nontechnical skills such as clinical and communication skills are mostly overlooked or not readily retrievable from medical records. Our aim was to estimate the association of technical and nontechnical skills of endoscopists with indemnity payments to patients after endoscopic perforations. METHODS This is an observational registry-based study of closed claims against gastroenterologists involved in endoscopic perforations. RESULTS We analyzed 175 closed claims related to perforations, all of which involved allegations of improper performance of the endoscopic procedure. Inadequate communication (n = 71, 41%) and clinical judgment (n = 60, 34%) on the part of the endoscopists were observed. Inadequate communication and clinical judgment were associated with over 3-fold odds of indemnity payment (odds ratio [OR] 3.31; 95% confidence interval [CI], 1.46-7.48, and OR 3.18; 95% CI, 1.44-7.01, respectively). However, if there were no communication breakdown or clinical judgment issues and the only allegation was poor technical skill, the odds of indemnity payments were less than half of those cases (OR 0.43; 95% CI 0.15-0.80). There was no evidence of a statistically significant interaction among age, procedure type, trainee involvement, clinical severity, need for surgery, and procedure-related death. DISCUSSION We observed that inadequate communication and clinical judgment were associated with indemnity payment, independent of the severity of clinical outcomes. On the other hand, cases wherein there was an allegation of poor technical skills alone, without communication breakdown or clinical judgment issues, were associated with favorable legal outcomes for the defendant. (See the Visual Abstract at http://links.lww.com/AJG/B568.).

Published
2020

48. List of Contributors

Author

Adler, Douglas G., primary, Ahlawat, Sushil K., additional, Ahmad, Jawad, additional, Al-Kawas, Firas H., additional, Alsulaiman, Raed M., additional, Ang, Tiing Leong, additional, Baillie, John, additional, Barkun, Alan, additional, Baron, Todd H., additional, Bhandari, Suryaprakash, additional, Binmoeller, Kenneth F., additional, Brugge, William R., additional, Buscaglia, Jonathan M., additional, Carr-Locke, David L., additional, Chan, Annie On-On, additional, Chang, Suyi, additional, Chen, Ann M., additional, Costamagna, Guido, additional, De Palma, Giovanni D., additional, Deviere, Jacques, additional, Farrell, James J., additional, Fockens, Paul, additional, Fox, Victor L., additional, Frakes, James T., additional, Freeman, Martin L., additional, Geenen, Joseph E., additional, Ginsberg, Gregory G., additional, Gobelet, Jaquelina M., additional, Goh, Khean-Lee, additional, Guda, Nalini M, additional, Hawes, Robert H., additional, Hochberger, Jürgen, additional, Jajoo, Kunal, additional, Joyce, Ann Marie, additional, Kalloo, Anthony N., additional, Kelsey, Peter B., additional, Kimmey, Michael B., additional, Kochman, Michael L., additional, Kodama, Tadashi, additional, Koshitani, Tatsuya, additional, Kozarek, Richard A., additional, Lee, Yuk Tong, additional, Lehman, Glen A., additional, Leung, Joseph W., additional, Liu, Chi Leung, additional, Lo, Simon K., additional, Maiss, Jürgen, additional, Maydeo, Amit, additional, Menke, Detlev, additional, Morgan, Desiree E., additional, Navarrete, Claudio, additional, Neuhaus, Horst, additional, Ong, Wai Choung, additional, Outlaw, William M., additional, Petersen, Bret T., additional, Ponsky, Jeffrey L., additional, Venkat Rao, G., additional, Reddy, Nageshwar, additional, Rupa, Banerjee, additional, Seewald, Stefan, additional, Seo, Dong Wan, additional, Shah, Syed G., additional, Sherman, Stuart, additional, Shim, Chan-Sup, additional, Shimpi, Lalit, additional, Singh, Hardeep M., additional, Slivka, Adam, additional, Soehendra, Nib, additional, van Soest, Ellert J., additional, Spencer, Geoffrey, additional, Sung, Joseph, additional, Tarnasky, Paul R., additional, Tatsumi, Yoshihide, additional, Topazian, Mark, additional, Valdivieso, Eduardo, additional, Watkins, James L, additional, Wong, Benjamin Chun-Yu, additional, and Zuccaro, Gregory, additional

Published
2008
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