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[[alpha].sub.1]-Adrenoceptors are G-protein-coupled receptors that bind catecholamines. Sixteen distinct human [[alpha].sub.1A]-adrenoceptor isoforms have been identified from human tissues, including five full-length and 11 truncated versions. An updated scheme for the identification of [[alpha].sub.1A]-adrenoceptor splice variants is proposed. Given the established roles of [[alpha].sub.1]-adrenoceptors in benign prostatic hyperplasia, myocardial hypertrophy and other cardiovascular disorders, elucidation of the biological significance of the signaling diversity and potential pharmacological roles of [[alpha].sub.1A]-adrenoceptor splice variants are important areas of future research.