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156 results on '"Gugliandolo, P."'

2. Symptomatic post COVID patients have impaired alveolar capillary membrane function and high VE/VCO2

Author

Agostoni, Piergiuseppe, Mapelli, Massimo, Salvioni, Elisabetta, Mattavelli, Irene, Banfi, Cristina, Bonomi, Alice, Biondi, Maria Luisa, Rovai, Sara, Tamborini, Gloria, Muratori, Manuela, Ghulam Ali, Sarah, Ghilardi, Stefania, De Martino, Fabiana, Vignati, Carlo, Palermo, Pietro, Gugliandolo, Paola, Elia, Davide, Moscucci, Federica, Cassandro, Roberto, Andreini, Daniele, Mancini, Elisabetta, and Harari, Sergio

Published
2024
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4. 3D-printed boluses for radiotherapy: influence of geometrical and printing parameters on dosimetric characterization and air gap evaluation

Author

Gugliandolo, Simone Giovanni, Pillai, Shabarish Purushothaman, Rajendran, Shankar, Vincini, Maria Giulia, Pepa, Matteo, Pansini, Floriana, Zaffaroni, Mattia, Marvaso, Giulia, Alterio, Daniela, Vavassori, Andrea, Durante, Stefano, Volpe, Stefania, Cattani, Federica, Jereczek-Fossa, Barbara Alicja, Moscatelli, Davide, and Colosimo, Bianca Maria

Published
2024
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6. Parents of Children with Developmental Disorders: Family Hardiness and Resilience

Author

Gugliandolo, Maria Cristina, Liga, Francesca, Larcan, Rosalba, and Cuzzocrea, Francesca

Abstract

Background: Raising a child with developmental disorder is often related to higher stress levels for both mothers and fathers. The aim of the present study was to investigate relationships between resilience, family hardiness, life satisfaction and parental stress among parents of children with and without disabilities. Method: Twenty-eight pairs of parents of a child with Autism Spectrum Disorder, 15 of a child with Down Syndrome and 25 of a child without disability took part in the study. All parents completed four questionnaires independently. Results: Significant differences between groups emerged in parental resilience, stress, and life satisfaction. Correlational analyses showed that parental hardiness and resilience were negatively related to parental stress through all the three groups. Conclusions: These findings point to increased evidence that the presence of a disability may not directly affect the sense of family hardiness. Practical implications were discussed.

Published
2023
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7. Dapagliflozin treatment is associated with a reduction of epicardial adipose tissue thickness and epicardial glucose uptake in human type 2 diabetes

Author

Cinti, Francesca, Leccisotti, Lucia, Sorice, Gian Pio, Capece, Umberto, D’Amario, Domenico, Lorusso, Margherita, Gugliandolo, Shawn, Morciano, Cassandra, Guarneri, Andrea, Guzzardi, Maria Angela, Mezza, Teresa, Capotosti, Amedeo, Indovina, Luca, Ferraro, Pietro Manuel, Iozzo, Patricia, Crea, Filippo, Giordano, Alessandro, and Giaccari, Andrea

Published
2023
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13. MRI-based radiomics signature for localized prostate cancer: a new clinical tool for cancer aggressiveness prediction? Sub-study of prospective phase II trial on ultra-hypofractionated radiotherapy (AIRC IG-13218)

Author

Gugliandolo, Simone Giovanni, Pepa, Matteo, Isaksson, Lars Johannes, Marvaso, Giulia, Raimondi, Sara, Botta, Francesca, Gandini, Sara, Ciardo, Delia, Volpe, Stefania, Riva, Giulia, Rojas, Damari Patricia, Zerini, Dario, Pricolo, Paola, Alessi, Sarah, Petralia, Giuseppe, Summers, Paul Eugene, Mistretta, Frnacesco Alessandro, Luzzago, Stefano, Cattani, Federica, De Cobelli, Ottavio, Cassano, Enrico, Cremonesi, Marta, Bellomi, Massimo, Orecchia, Roberto, and Jereczek-Fossa, Barbara Alicja

Published
2021
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17. Transcriptomic analysis revealed increased expression of genes involved in keratinization in the tears of COVID-19 patients

Author

Mastropasqua, Leonardo, Toto, Lisa, Chiricosta, Luigi, Diomede, Francesca, Gugliandolo, Agnese, Silvestro, Serena, Marconi, Guya Diletta, Sinjari, Bruna, Vecchiet, Jacopo, Cipollone, Francesco, D’Ardes, Damiano, Auricchio, Antonio, Lanzini, Manuela, Caputi, Sergio, D’Aloisio, Rossella, Mazzon, Emanuela, and Trubiani, Oriana

Published
2021
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19. Phase II prospective trial “Give Me Five” short-term high precision radiotherapy for early prostate cancer with simultaneous boost to the dominant intraprostatic lesion: the impact of toxicity on quality of life (AIRC IG-13218)

Author

Marvaso, Giulia, Gugliandolo, Simone Giovanni, Bellerba, Federica, Gandini, Sara, Corrao, Giulia, Volpe, Stefania, Rojas, Damaris Patricia, Riva, Giulia, Zerini, Dario, Pepa, Matteo, Fodor, Cristiana Iuliana, La Rocca, Eliana, Pricolo, Paola, Alessi, Sarah, Petralia, Giuseppe, Mistretta, Francesco Alessandro, Cambria, Raffaella, Cattani, Federica, De Cobelli, Ottavio, Orecchia, Roberto, and Jereczek-Fossa, Barbara Alicja

Published
2020
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25. P217 SHORT–TERM EFFECTS OF DAPAGLIFLOZIN ON CARDIAC BIOMARKERS, FLUID RETENTION, RENAL AND PULMONARY FUNCTION IN HFREF PATIENTS: NOT AS GOOD AS EXPECTED

Author

Mapelli, M, primary, Capovilla, T, additional, Marongiu, A, additional, Maranzano, G, additional, Salvioni, E, additional, Mattavelli, I, additional, Paganin, C, additional, Vignati, C, additional, Gugliandolo, P, additional, Mantegazza, V, additional, Garlaschè, A, additional, Sinagra, G, additional, and Agostoni, P, additional

Published
2023
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30. Periodic breathing: what happens in the muscle?

Author

De Martino, F., Mattavelli, I., Vignati, C., Salvioni, E., Campodonico, J., Mapelli, M., Gugliandolo, P., and Agostoni, P.

Subjects
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
Published
2022

34. A Wearable Device to Monitor the Partial Pressure of Transcutaneous Carbon Dioxide

Author

Angelucci, Alessandra, Bernasconi, Sara, Colombo, Luca, Contini, Mauro, Gugliandolo, Paola, Agostoni, Piergiuseppe, and Aliverti, Andrea

Abstract

The electrochemical approach with CO2 electrodes is the gold standard for the measurement of transcutaneous CO2 (PtCO2). However, this system requires the continuous calibration of the device, the remembranization of the electrodes, an infrastructure with specialized personnel, and a still position during the measurement. This article presents a wearable device for PtCO2 measurement with an optical approach (nondispersive infrared sensor). The device first measures the environmental CO2, then brings the skin temperature to 42 °C, and finally measures the actual PtCO2. The 30 volunteers (20 men and ten women, mean age 27.2 ± 7.0) were enrolled to validate the new device against the gold standard Sentec Digital monitor. The protocol consisted in 10 min of spontaneous breathing, 2 min of rebreathing in a 2-L bag to induce hypercapnia, and 12 min of recovery. This was repeated for each volunteer because the gold standard probe was placed once on the forearm and once at the earlobe. Also, a conversion method from ppm readings of the new device to mmHg was implemented and evaluated. The new device detects a response to the stimulus of hypercapnia with a time delay comparable to that of the gold standard. Before reaching a baseline, both devices require an assessment time approximatively in the order of minutes. The Sentec device goes back to the baseline after the end of the stimulus, while the new device saturates. After conversion of values into mmHg, the intraclass correlation coefficient (ICC) analysis on median values results in a coefficient of 0.75. The new device has a median root mean square error of 2.38 mmHg (IQR = 1.59 mmHg). The median of the mean absolute error is 2.05 mmHg (IQR = 1.64 mmHg) and the uncertainty is ±4.63 mmHg (IQR = 2.38 mmHg). This work demonstrates that a wearable device to measure PtCO2 based on an optical sensor is technically feasible.

Published
2024
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38. Immature circulating SP-B, bound to HDL, represents an early sign of smoke-induced pathophysiological alterations

Author

Banfi, C, Brioschi, M, Mapelli, M, Gianazza, E, Mallia, A, Zoanni, B, Salvioni, E, Gugliandolo, P, Capra, N, Veglia, F, Agostoni, P, Banfi C., Brioschi M., Mapelli M., Gianazza E., Mallia A., Zoanni B., Salvioni E., Gugliandolo P., Capra N., Veglia F., Agostoni P., Banfi, C, Brioschi, M, Mapelli, M, Gianazza, E, Mallia, A, Zoanni, B, Salvioni, E, Gugliandolo, P, Capra, N, Veglia, F, Agostoni, P, Banfi C., Brioschi M., Mapelli M., Gianazza E., Mallia A., Zoanni B., Salvioni E., Gugliandolo P., Capra N., Veglia F., and Agostoni P.

Abstract

Cigarette smoking is a major independent risk factor for cardiovascular diseases (CVD). The underlying mechanisms, however, are not clearly understood. Lungs are the primary route of exposure to smoke, with pulmonary cells and surfactant being the first structures directly exposed, resulting in the leakage of the immature proteoform of surfactant protein B (proSP‐B). Herein, we evaluated whether proSP‐B joined the cargo of high‐density lipoprotein (HDL) proteins in healthy young subjects (n = 106) without any CVD risk factor other than smoking, and if HDL‐associated proSP‐B (HDL‐SPB) correlated with pulmonary function parameters, systemic inflammation, and oxidative stress. At univariable analysis, HDL‐SPB resulted significantly higher in smokers (2.2‐ fold, p < 0.001) than in non‐smokers. No significant differences have been detected between smokers and non‐smokers for inflammation, oxidation variables, and alveolar‐capillary diffusion markers. In a multivariable model, HDL‐SPB was independently associated with smoking. In conclusion, HDL‐SPB is not only a precocious and sensitive index of the acute effects of smoke, but it might be also a potential causal factor in the onset of the vascular damage induced by modified HDL. These findings contribute to the emerging concept that the quality of the HDL proteome, rather than the quantity of particles, plays a central role in CVD risk protection.

Published
2021

44. The alveolar–capillary unit in the physiopathological conditions of heart failure: identification of a potential marker

Author

Banfi, Cristina, Gugliandolo, Paola, Paolillo, Stefania, Mallia, Alice, Gianazza, Erica, and Agostoni, Piergiuseppe

Abstract

In this review, we describe the structure and function of the alveolar–capillary membrane and the identification of a novel potential marker of its integrity in the context of heart failure (HF). The alveolar–capillary membrane is indeed a crucial structure for the maintenance of the lung parenchyma gas exchange capacity, and the occurrence of pathological conditions determining lung fluids accumulation, such as HF, might significantly impair lung diffusion capacity altering the alveolar–capillary membrane protective functions. In the years, we found that the presence of immature forms of the surfactant protein-type B (proSP-B) in the circulation reflects alterations in the alveolar–capillary membrane integrity. We discussed our main achievements showing that proSP-B, due to its chemical properties, specifically binds to high-density lipoprotein, impairing their antioxidant activity, and likely contributing to the progression of the disease. Further, we found that immature proSP-B, not the mature protein, is related to lung abnormalities, more precisely than the lung function parameters. Thus, to the list of the potential proposed markers of HF, we add proSP-B, which represents a precise marker of alveolar–capillary membrane dysfunction in HF, correlates with prognosis, and represents a precocious marker of drug therapy.

Published
2023
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45. Dysregulation of ventilation at day and night time in heart failure

Author

Contini, Mauro, Mapelli, Massimo, Carriere, Cosimo, Gugliandolo, Paola, Aliverti, Andrea, Piepoli, Massimo, Angelucci, Alessandra, Baracchini, Nikita, Capovilla, Maria Teresa, and Agostoni, Piergiuseppe

Abstract

Heart failure (HF) is characterized by an increase in ventilatory response to exercise of multifactorial aetiology and by a dysregulation in the ventilatory control during sleep with the occurrence of both central and obstructive apnoeas. In this setting, the study of the ventilatory behaviour during exercise, by cardiopulmonary exercise testing, or during sleep, by complete polysomnography or simplified nocturnal cardiorespiratory monitoring, is of paramount importance because of its prognostic value and of the possible effects of sleep-disordered breathing on the progression of the disease. Moreover, several therapeutic interventions can significantly influence ventilatory control in HF. Also, rest daytime monitoring of cardiac, metabolic, and respiratory activities through specific wearable devices could provide useful information for HF management. The aim of the review is to summarize the main studies conducted at Centro Cardiologico Monzino on these topics.

Published
2023
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46. Activities of daily living in heart failure patients and healthy subjects: when the cardiopulmonary assessment goes beyond traditional exercise test protocols

Author

Mapelli, Massimo, Salvioni, Elisabetta, Mattavelli, Irene, Gugliandolo, Paola, Bonomi, Alice, Palermo, Pietro, Rossi, Maddalena, Stolfo, Davide, Gustafsson, Finn, Piepoli, Massimo, and Agostoni, Piergiuseppe

Abstract

Heart failure (HF) patients traditionally report dyspnoea as their main symptom. Although the cardiopulmonary exercise test (CPET) and 6 min walking test are the standardized tools in assessing functional capacity, neither cycle ergometers nor treadmill maximal efforts do fully represent the actual HF patients’ everyday activities [activities of daily living (ADLs)] (i.e. climbing the stairs). New-generation portable metabolimeters allow the clinician to measure task-related oxygen intake (VO2) in different scenarios and exercise protocols. In the last years, we have made considerable progress in understanding the ventilatory and metabolic behaviours of HF patients and healthy subjects during tasks aimed to reproduce ADLs. In this paper, we describe the most recent findings in the field, with special attention to the relationship between the metabolic variables obtained during ADLs and CPET parameters (i.e. peak VO2), demonstrating, for example, how exercises traditionally thought to be undemanding, such as a walk, instead represent supramaximal efforts, particularly for subjects with advanced HF and/or artificial heart (left ventricular assist devices) wearers.This article summarizes the most recent evidence on the cardiometabolic behaviours of a full spectrum of heart failure (HF) patients of different severity during their daily life activities (i.e. walking, making a bed, and taking the stairs).Heart failure patients experience symptoms (mostly dyspnoea) during daily activities that sometimes represent maximal or supramaximal exercises for them, particularly for the most severe patients.Measuring metabolic parameters (O2intake, ventilation, and CO2production) through appropriate devices during these activities provides a better understanding of the pathophysiological mechanisms underlying HF patients’ symptoms and their adaptation. This can lead to the detection of new parameters that can become novel patient-centred prognostic markers or therapeutic targets for drugs and rehabilitation treatments.

Published
2023
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47. C73 PICK YOUR THRESHOLD! HOW TO CALCULATE THE ANAEROBIC THRESHOLD TO STRATIFY HEART FAILURE PROGNOSIS: A COMPARISON BETWEEN ABSOLUTE VALUE, PERCENTAGE OF PEAK VO2 OR PERCENTAGE OF PREDICTED MAXIMUM VO2 IN A LARGE MULTICENTER COHORT OF HFREF PATIENTS WHO UNDER

Author

Elisabetta, S, primary, Mapelli, M, additional, Bonomi, A, additional, Mattavelli, I, additional, De Martino, F, additional, Vignati, C, additional, Gugliandolo, P, additional, and Agostoni, P, additional

Published
2022
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49. Pick Your Threshold: A Comparison Among Different Methods of Anaerobic Threshold Evaluation in Heart Failure Prognostic Assessment

Author

Salvioni, E., Mapelli, M., Bonomi, A., Magri, D., Piepoli, M., Frigerio, M., Paolillo, S., Corra, U., Raimondo, R., Lagioia, R., Badagliacca, R., Filardi, P. P., Senni, M., Correale, M., Cicoira, M., Perna, E., Metra, M., Guazzi, M., Limongelli, G., Sinagra, G., Parati, G., Cattadori, G., Bandera, F., Bussotti, M., Re, F., Vignati, C., Lombardi, C., Scardovi, A. B., Sciomer, S., Passantino, A., Emdin, M., Passino, C., Santolamazza, C., Girola, D., Zaffalon, D., De Martino, F., Agostoni, P., Farina, S., Pezzuto, B., Apostolo, A., Palermo, P., Contini, M., Gugliandolo, P., Mattavelli, I., Della Rocca, M., Gallo, G., Moscucci, F., Iorio, A., Halasz, G., Capelli, B., Binno, S., Pacileo, G., Valente, F., Vastarella, R., Carriere, C., Mase, M., Cittar, M., Di Lenarda, A., Caravita, S., Vigano, E., Marchese, G., Ricci, R., Arcari, L., Scrutinio, D., Battaia, E., Moretti, M., Matassini, M. V., Shkoza, M., Herberg, R., Cittadini, A., Salzano, A., Marra, A., Lafranca, E., and Vitale, G.

Subjects
heart failure, prognosis, anaerobic threshold, cardiopulmonary exercise test
Published
2022

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