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15. Alterations of the gut microbiota in patients with schizophrenia

Author

Li, Zhuocan, primary, Tao, Xiangkun, additional, Wang, Dongfang, additional, Pu, Juncai, additional, Liu, Yiyun, additional, Gui, Siwen, additional, Zhong, Xiaogang, additional, Yang, Dan, additional, Zhou, Haipeng, additional, Tao, Wei, additional, Chen, Weiyi, additional, Chen, Xiaopeng, additional, Chen, Yue, additional, Chen, Xiang, additional, and Xie, Peng, additional

Published
2024
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16. Age-related changes after intracerebral hemorrhage: a comparative proteomics analysis of perihematomal tissue

Author

Li, Xinhui, primary, Xiao, Zhongsong, additional, Li, Peizheng, additional, Yang, Wensong, additional, Shen, Yiqing, additional, Liu, Fangyu, additional, Xiong, Xin, additional, Wu, Qingyuan, additional, Wang, Peng, additional, Dang, Ruozhi, additional, Gui, Siwen, additional, Deng, Lan, additional, Manaenko, Anatol, additional, Xie, Peng, additional, and Li, Qi, additional

Published
2024
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23. Chronic Stress in a Rat Model of Depression Disturbs the Glutamine–Glutamate–GABA Cycle in the Striatum, Hippocampus, and Cerebellum

Author

Xu, Shaohua, Liu, Yiyun, Pu, Juncai, Gui, Siwen, Zhong, Xiaogang, Tian, Lu, Song, Xuemian, Qi, Xunzhong, Wang, Haiyang, and Xie, Peng

Subjects
nervous system, striatum, GC/MS, glutamine–glutamate–GABA cycle, depression, chronic unpredictable mild stress, Original Research
Abstract

Background Major depressive disorder (MDD) is a complex psychiatric illness involving multiple brain regions. Increasing evidence indicates that the striatum is involved in depression, but the molecular mechanisms remain unclear. Methods In this study, we performed a gas chromatography–mass spectrometer (GC/MS)-based metabolomic analysis in the striatum of depressed rats induced by chronic unpredictable mild stress (CUMS). We then compared striatal data with our previous data from the hippocampus and cerebellum to systematically investigate the potential pathogenesis of depression. Results We identified 22 differential metabolites in the striatum between the CUMS and control groups; these altered metabolites were mainly involved in amino acid, carbohydrate, and nucleotide metabolism. Pathway analysis revealed that the shared metabolic pathways of the striatum, hippocampus, and cerebellum were mainly involved in the glutamine–glutamate metabolic system. Four genes in the striatum (GS, GLS2, GLT1, and SSADH), six genes in the hippocampus (GS, SNAT1, GAD1, SSADH, VGAT, and ABAT), and five genes in the cerebellum (GS, ABAT, SNAT1, VGAT, and GDH) were found to be significantly altered using RT-qPCR. Correlation analysis indicated that these differential genes were strongly correlated. Conclusion These results suggest that chronic stress might induce depressive behaviors by disturbing the glutamine–glutamate–GABA cycle in the striatum, hippocampus, and cerebellum, and that the glutamine–glutamate–GABA cycle among these three brain regions might generate cooperative action in response to chronic stress.

Published
2020

24. Integrative Analysis of Long Non-coding RNAs, Messenger RNAs, and MicroRNAs Indicates the Neurodevelopmental Dysfunction in the Hippocampus of Gut Microbiota-Dysbiosis Mice

Author

Liu, Lanxiang, primary, Wang, Haiyang, additional, Chen, Xueyi, additional, Zhang, Yangdong, additional, Li, Wenxia, additional, Rao, Xuechen, additional, Liu, Yiyun, additional, Zhao, Libo, additional, Pu, Juncai, additional, Gui, Siwen, additional, Yang, Deyu, additional, Fang, Liang, additional, and Xie, Peng, additional

Published
2022
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25. Integrated Multiomics Analysis Identifies a Novel Biomarker Associated with Prognosis in Intracerebral Hemorrhage

Author

Shen, Yiqing, primary, Yang, Wensong, additional, Xiong, Xin, additional, Li, Xinhui, additional, Xiao, Zhongsong, additional, Yu, Jialun, additional, Liu, Fangyu, additional, Gui, Siwen, additional, Xie, Xiongfei, additional, Lv, Fajin, additional, Zhao, Libo, additional, Hu, Liangbo, additional, Manaenko, Anatol, additional, Xie, Peng, additional, and Li, Qi, additional

Published
2021
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26. Transcriptomics Analysis Reveals Shared Pathways in Peripheral Blood Mononuclear Cells and Brain Tissues of Patients With Schizophrenia

Author

Song, Xuemian, primary, Liu, Yiyun, additional, Pu, Juncai, additional, Gui, Siwen, additional, Zhong, Xiaogang, additional, Chen, Xiaopeng, additional, Chen, Weiyi, additional, Chen, Xiang, additional, Chen, Yue, additional, Wang, Haiyang, additional, Cheng, Ke, additional, Zhao, Libo, additional, and Xie, Peng, additional

Published
2021
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27. Alteration of lipids and amino acids in plasma distinguish schizophrenia patients from controls: A targeted metabolomics study

Author

Liu, Yiyun, primary, Song, Xuemian, additional, Liu, Xinyu, additional, Pu, Juncai, additional, Gui, Siwen, additional, Xu, Shaohua, additional, Tian, Lu, additional, Zhong, Xiaogang, additional, Zhao, Libo, additional, Wang, Haiyang, additional, Liu, Lanxiang, additional, Xu, Guowang, additional, and Xie, Peng, additional

Published
2021
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29. Chronic Stress in a Rat Model of Depression Disturbs the Glutamine–Glutamate–GABA Cycle in the Striatum, Hippocampus, and Cerebellum

Author

Xu,Shaohua, Liu,Yiyun, Pu,Juncai, Gui,Siwen, Zhong,Xiaogang, Tian,Lu, Song,Xuemian, Qi,Xunzhong, Wang,Haiyang, Xie,Peng, Xu,Shaohua, Liu,Yiyun, Pu,Juncai, Gui,Siwen, Zhong,Xiaogang, Tian,Lu, Song,Xuemian, Qi,Xunzhong, Wang,Haiyang, and Xie,Peng

Abstract

Shaohua Xu, 1–3,* Yiyun Liu, 2, 3,* Juncai Pu, 2, 3,* Siwen Gui, 2–4,* Xiaogang Zhong, 2, 3 Lu Tian, 2, 3 Xuemian Song, 2–4 Xunzhong Qi, 2, 3 Haiyang Wang, 2, 3 Peng Xie 1–3, 5 1Department of Neurology, Yongchuan Hospital, Chongqing Medical University, Chongqing 402160, People’s Republic of China; 2NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of China; 3Chongqing Key Laboratory of Neurobiology, Chongqing 400016, People’s Republic of China; 4College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, People’s Republic of China; 5Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Peng XieNHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, People’s Republic of ChinaTel +86-023-68485490Fax +86-023-68485111Email xiepeng@cqmu.edu.cnBackground: Major depressive disorder (MDD) is a complex psychiatric illness involving multiple brain regions. Increasing evidence indicates that the striatum is involved in depression, but the molecular mechanisms remain unclear.Methods: In this study, we performed a gas chromatography–mass spectrometer (GC/MS)-based metabolomic analysis in the striatum of depressed rats induced by chronic unpredictable mild stress (CUMS). We then compared striatal data with our previous data from the hippocampus and cerebellum to systematically investigate the potential pathogenesis of depression.Results: We identified 22 differential metabolites in the striatum between the CUMS and control groups; these altered metabolites were mainly involved in amino acid, carb

Published
2020

30. An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder

Author

Pu, Juncai, primary, Liu, Yiyun, additional, Zhang, Hanping, additional, Tian, Lu, additional, Gui, Siwen, additional, Yu, Yue, additional, Chen, Xiang, additional, Chen, Yue, additional, Yang, Lining, additional, Ran, Yanqin, additional, Zhong, Xiaogang, additional, Xu, Shaohua, additional, Song, Xuemian, additional, Liu, Lanxiang, additional, Zheng, Peng, additional, Wang, Haiyang, additional, and Xie, Peng, additional

Published
2020
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31. Sex‐specific plasma metabolome signatures in major depressive disorder

Author

Pu, Juncai, primary, Liu, Xinyu, additional, Liu, Yiyun, additional, Gui, Siwen, additional, Zhong, Xiaogang, additional, Tian, Lu, additional, Yang, Lining, additional, Xu, Shaohua, additional, Song, Xuemian, additional, Chen, Xiang, additional, Chen, Yue, additional, Wang, Haiyang, additional, Xu, Guowang, additional, and Xie, Peng, additional

Published
2019
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33. MENDA: a comprehensive curated resource of metabolic characterization in depression

Author

Pu, Juncai, primary, Yu, Yue, additional, Liu, Yiyun, additional, Tian, Lu, additional, Gui, Siwen, additional, Zhong, Xiaogang, additional, Fan, Chu, additional, Xu, Shaohua, additional, Song, Xuemian, additional, Liu, Lanxiang, additional, Yang, Lining, additional, Zheng, Peng, additional, Chen, Jianjun, additional, Cheng, Ke, additional, Zhou, Chanjuan, additional, Wang, Haiyang, additional, and Xie, Peng, additional

Published
2019
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34. The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice

Author

Zheng, Peng, primary, Zeng, Benhua, additional, Liu, Meiling, additional, Chen, Jianjun, additional, Pan, Junxi, additional, Han, Yu, additional, Liu, Yiyun, additional, Cheng, Ke, additional, Zhou, Chanjuan, additional, Wang, Haiyang, additional, Zhou, Xinyu, additional, Gui, Siwen, additional, Perry, Seth W., additional, Wong, Ma-Li, additional, Licinio, Julio, additional, Wei, Hong, additional, and Xie, Peng, additional

Published
2019
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35. MENDA: a comprehensive curated resource of metabolic characterization in depression.

Author

Pu, Juncai, Yu, Yue, Liu, Yiyun, Tian, Lu, Gui, Siwen, Zhong, Xiaogang, Fan, Chu, Xu, Shaohua, Song, Xuemian, Liu, Lanxiang, Yang, Lining, Zheng, Peng, Chen, Jianjun, Cheng, Ke, Zhou, Chanjuan, Wang, Haiyang, and Xie, Peng

Subjects
WEB search engines, DATA integration, HYPERTEXT literature, DATA extraction, ELECTRONIC data processing, BIBLIOGRAPHIC databases, BIOLOGICAL databases
Abstract

Depression is a seriously disabling psychiatric disorder with a significant burden of disease. Metabolic abnormalities have been widely reported in depressed patients and animal models. However, there are few systematic efforts that integrate meaningful biological insights from these studies. Herein, available metabolic knowledge in the context of depression was integrated to provide a systematic and panoramic view of metabolic characterization. After screening more than 10 000 citations from five electronic literature databases and five metabolomics databases, we manually curated 5675 metabolite entries from 464 studies, including human, rat, mouse and non-human primate, to develop a new metabolite-disease association database, called MENDA (http://menda.cqmu.edu.cn:8080/index.php). The standardized data extraction process was used for data collection, a multi-faceted annotation scheme was developed, and a user-friendly search engine and web interface were integrated for database access. To facilitate data analysis and interpretation based on MENDA, we also proposed a systematic analytical framework, including data integration and biological function analysis. Case studies were provided that identified the consistently altered metabolites using the vote-counting method, and that captured the underlying molecular mechanism using pathway and network analyses. Collectively, we provided a comprehensive curation of metabolic characterization in depression. Our model of a specific psychiatry disorder may be replicated to study other complex diseases. [ABSTRACT FROM AUTHOR]

Published
2020
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37. Activation of ERK/CREB/BDNF pathway involved in abnormal behavior of neonatally Borna virus-infected rats

Author

Li,Chenmeng, Xu,Xiaoyan, Zhang,Xiong, Cheng,Ke, Guo,Yujie, Jie,Jie, Guo,Hua, He,Yong, Zhou,Chanjuan, Gui,Siwen, Zhong,Xiaogang, Wang,Haiyang, Xie,Peng, Li,Chenmeng, Xu,Xiaoyan, Zhang,Xiong, Cheng,Ke, Guo,Yujie, Jie,Jie, Guo,Hua, He,Yong, Zhou,Chanjuan, Gui,Siwen, Zhong,Xiaogang, Wang,Haiyang, and Xie,Peng

Abstract

Chenmeng Li,1–3,* Xiaoyan Xu,2–4,* Xiong Zhang,2–4,* Ke Cheng,2,3,* Yujie Guo,1–3 Jie Jie,1–3 Hua Guo,1–3 Yong He,1–3 Chanjuan Zhou,2,3 Siwen Gui,2,3 Xiaogang Zhong,2,3 Haiyang Wang,2–4 Peng Xie1–4 1Department of Neurology, Yongchuan Hospital of Chongqing Medical University, Chongqing 402460, China; 2Department of Neurology Institute of Neuroscience and Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing 400016, China; 3Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China; 4Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China *These authors contributed equally to this work Background: Neuropsychiatric disorders are devastating illnesses worldwide; however, the potential involvement of viruses in the pathophysiological mechanisms of psychiatric diseases have not been clearly elucidated. Borna disease virus (BDV) is a neurotropic, noncytopathic RNA virus. Materials and methods: In this study, we infected neonatal rats intracranially with BDV Hu-H1 and Strain V within 24 hours of birth. Psychological phenotypes were assessed using sucrose preference test, open field test, elevated plus maze test, and forced swim test. The protein expression of ERK/CREB/BDNF pathway was assessed by Western blotting of in vitro and in vivo samples. Results: Hu-H1-infected rats showed anxiety-like behavior 8 weeks postinfection while Strain V-infected rats demonstrated a certain abnormal behavior. Phosphorylated ERK1/2 was significantly upregulated in the hippocampi of Strain V- and Hu-H1-infected rats compared with control rats, indicating that Raf/MEK/ERK signaling was activated. Conclusion: The data suggested that infection of neonatal rats with BDV Hu-H1 and Strain V caused behavioral abnormalities that shared common molecular pathways, providing preliminary evidences to investi

Published
2018

38. Proteomic Profiling Reveals Microbiota-Driven Sensing Mechanisms of Gut-Brain Axis in Depression

Author

Liu, Yiyun, primary, Luo, Yuanyuan, additional, Zeng, Benhua, additional, Gui, Siwen, additional, Zheng, Peng, additional, Zeng, Li, additional, Pu, Juncai, additional, Wang, Haiyang, additional, Wu, You, additional, Zhou, Chanjuan, additional, Zhong, Xiaogang, additional, Tian, Lu, additional, Xu, Shaohua, additional, Song, Xuemian, additional, Wei, Hong, additional, and Xie, Peng, additional

Published
2018
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39. Insight into the metabolic mechanism of Diterpene Ginkgolides on antidepressant effects for attenuating behavioural deficits compared with venlafaxine

Author

Bai, Shunjie, primary, Zhang, Xiaodong, additional, Chen, Zhi, additional, Wang, Wei, additional, Hu, Qingchuan, additional, Liang, Zihong, additional, Shen, Peng, additional, Gui, Siwen, additional, Zeng, Li, additional, Liu, Zhao, additional, Chen, Jianjun, additional, Xie, Xiongfei, additional, Huang, Hua, additional, Han, Yu, additional, Wang, Haiyang, additional, and Xie, Peng, additional

Published
2017
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40. Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex.

Author

Hu, Qingchuan, Shen, Peng, Bai, Shunjie, Dong, Meixue, Liang, Zihong, Chen, Zhi, Wang, Wei, Wang, Haiyang, Gui, Siwen, Li, Pengfei, and Xie, Peng

Subjects
METABOLITES, ANTIDEPRESSANTS, GINKGOLIDES, PREFRONTAL cortex, GINKGO, THERAPEUTIC use of plant extracts, NEUROPROTECTIVE agents
Abstract

Purpose: Ginkgo biloba extract (GBE) contains diterpene ginkgolides (DGs), which have been shown to have neuroprotective effects by a number of previous studies. We previously demonstrated part of the action of DG. However, the impact of DG on the prefrontal cortex (PFC) remains unclear. Here, we evaluated the effects of DG and venlafaxine (for comparison) on behavioral and metabolite changes in the PFC using mice models and gas chromatography–mass spectrometry-based metabolomics. Materials and methods: Mice were randomly divided into control (saline), DG (12.18 mg/kg) and venlafaxine (16 mg/kg) groups. After 2 weeks of treatment, depression and anxiety-related behavioral tests were performed. Metabolic profiles of the PFC were detected by gas chromatography–mass spectrometry. Results: The DG group exhibited positive effects in the sucrose preference test. The differential metabolites were mainly related to amino acid metabolism, energy metabolism and lipid metabolism. The results indicated that the DG group exhibited perturbed lipid metabolism, molecular transport and small-molecule biochemistry in the PFC. Compared with the control group, pathway analysis indicated that venlafaxine and DG had similar effects on alanine, aspartate and glutamate metabolism. Conclusion: These findings demonstrate that DG has antidepressant-like, but not anxiolytic-like, effects in mice, suggesting that it might have therapeutic potential for the treatment of major depressive disorder. [ABSTRACT FROM AUTHOR]

Published
2018
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