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21 results on '"Guillot Raphael"'

7. Transfer of continuous manufacturing process principles for mAb production in a GMP environment: A step in the transition from batch to continuous

Author

Botelho Ferreira, Kevin, primary, Benlegrimet, Asma, additional, Diane, Gabriel, additional, Pasquier, Victor, additional, Guillot, Raphael, additional, De Poli, Marc, additional, Chappuis, Loïc, additional, Vishwanathan, Nandita, additional, Souquet, Jonathan, additional, Broly, Hervé, additional, and Bielser, Jean‐Marc, additional

Published
2022
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12. How cells internalize a growth factor presented by a biomaterial: BMP-2 delivery to cells in a matrix-bound manner using layer-by-layer films

Author

Picart Catherine, Gilde Flora, Fourel Laure, Guillot Raphael, Paintrand Isabelle, Okada Takaharu, Boudou Thomas, and Albigez-Rizo Corinne

Subjects
Histology, Chemistry, Growth factor, medicine.medical_treatment, Layer by layer, Biomedical Engineering, Biophysics, medicine, Biomaterial, Bioengineering, Matrix bound, Bone morphogenetic protein 2, Biotechnology
Published
2016

13. Osteoinductive coatings of implantable materials

Author

Guillot, Raphael, Gilde, Flora, Becquart, P., Pignot-Paintrand, Isabelle, Lapeyrere, Aurelien, Sailhan, F., Logeart-Avramoglou, D., Picart, Catherine, Lmgp, Labo, Laboratoire des matériaux et du génie physique (LMGP ), Institut National Polytechnique de Grenoble (INPG)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Bioingénierie et Bioimagerie Ostéo-articulaires, Biomécanique et Biomatériaux Ostéo-Articulaires (B2OA (UMR_7052)), and École nationale vétérinaire d'Alfort (ENVA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2014

21. β3 integrin-mediated spreading induced by matrix-bound BMP-2 controls Smad signaling in a stiffness-independent manner.

Author

Foure, Laure, Valat, Anne, Faurobert, Eva, Guillot, Raphael, Bourrin-Reynard, Ingrid, Kefeng Ren, Lafanechère, Laurence, Planus, Emmanuelle, Picart, Catherine, and Albiges-Rizo, Corinne

Subjects
*CELL differentiation, *INTEGRINS, *CELL adhesion, *BIOMATERIALS, *HOMEOSTASIS, *REGENERATIVE medicine
Abstract

Understanding how cells integrate multiple signaling pathways to achieve specific cell differentiation is a challenging question in cell biology. We have explored the physiological presentation of BMP-2 by using a biomaterial that harbors tunable mechanical properties to promote localized BMP-2 signaling. We show that matrix-bound BMP-2 is sufficient to induce β3 integrin-dependent C2C12 cell spreading by overriding the soft signal of the biomaterial and impacting actin organization and adhesion site dynamics. In turn, αvβ3 integrin is required to mediate BMP-2-induced Smad signaling through a Cdc42-Src-FAK-ILK pathway. β3 integrin regulates a multistep process to control first BMP-2 receptor activity and second the inhibitory role of GSK3 on Smad signaling. Overall, our results show that BMP receptors and β3 integrin work together to control Smad signaling and tensional homeostasis, thereby coupling cell adhesion and fate commitment, two fundamental aspects of developmental biology and regenerative medicine. [ABSTRACT FROM AUTHOR]

Published
2016
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