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16 results on '"Guillou, Clément"'

2. Gingival proteomics reveals the role of TGF beta and YAP/TAZ signaling in Raine syndrome fibrosis

Author

Costa, Cláudio Rodrigues Rezende, Chalgoumi, Rym, Baker, Amina, Guillou, Clément, Yamaguti, Paulo Marcio, Simancas Escorcia, Victor, Abbad, Lilia, Amorin, Bruna Rabelo, de Lima, Caroline Lourenço, Cannaya, Vidjea, Benassarou, Mourad, Berdal, Ariane, Chatziantoniou, Christos, Cases, Olivier, Cosette, Pascal, Kozyraki, Renata, and Acevedo, Ana Carolina

Published
2024
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5. Pathogenesis of Enamel-Renal Syndrome Associated Gingival Fibromatosis: A Proteomic Approach

Author

Simancas Escorcia, Victor, Guillou, Clément, Abbad, Lilia, Derrien, Louise, Rodrigues Rezende Costa, Claudio, Cannaya, Vidjea, Benassarou, Mourad, Chatziantoniou, Christos, Berdal, Ariane, Acevedo, Ana Carolina, Cases, Olivier, Cosette, Pascal, Kozyraki, Renata, Physiopathologie orale moléculaire = Molecular Oral Pathophysiology [CRC], Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Plate-forme de Protéomique PISSARO, Institute for Research and Innovation in Biomedicine (IRIB), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Polymères Biopolymères Surfaces (PBS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), University of Brasilia [Brazil] (UnB), Service de Stomatologie et Chirurgie Maxillo-facial [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Rothschild [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Paris – UFR Odontologie Garancière [Santé] (UP UFR Odontologie G), Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-High-tech Research Infrastructures for Life Sciences (HeRacLeS), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Paris Cité – UFR Odontologie [Santé] (UPCité UFR Odontologie), Université Paris Cité (UPCité), and CASES, OLIVIER

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], fibrosis, enamel renal syndrome, gingival fibroblast, FAM20A, secretome analysis, TGF-beta, FAM20C, gingival fibromatosis
Abstract

International audience; The enamel renal syndrome (ERS) is a rare disorder featured by amelogenesis imperfecta , gingival fibromatosis and nephrocalcinosis. ERS is caused by bi-allelic mutations in the secretory pathway pseudokinase FAM20A. How mutations in FAM20A may modify the gingival connective tissue homeostasis and cause fibromatosis is currently unknown. We here analyzed conditioned media of gingival fibroblasts (GFs) obtained from four unrelated ERS patients carrying distinct mutations and control subjects. Secretomic analysis identified 109 dysregulated proteins whose abundance had increased (69 proteins) or decreased (40 proteins) at least 1.5-fold compared to control GFs. Proteins over-represented were mainly involved in extracellular matrix organization, collagen fibril assembly, and biomineralization whereas those under-represented were extracellular matrix-associated proteins. More specifically, transforming growth factor-beta 2, a member of the TGFβ family involved in both mineralization and fibrosis was strongly increased in samples from GFs of ERS patients and so were various known targets of the TGFβ signaling pathway including Collagens, Matrix metallopeptidase 2 and Fibronectin. For the over-expressed proteins quantitative RT-PCR analysis showed increased transcript levels, suggesting increased synthesis and this was further confirmed at the tissue level. Additional immunohistochemical and western blot analyses showed activation and nuclear localization of the classical TGFβ effector phospho-Smad3 in both ERS gingival tissue and ERS GFs. Exposure of the mutant cells to TGFB1 further upregulated the expression of TGFβ targets suggesting that this pathway could be a central player in the pathogenesis of the ERS gingival fibromatosis. In conclusion our data strongly suggest that TGFβ -induced modifications of the extracellular matrix contribute to the pathogenesis of ERS. To our knowledge this is the first proteomic-based analysis of FAM20A-associated modifications.

Published
2021

6. Anti-Carbamylated Fibrinogen Antibodies Might Be Associated With a Specific Rheumatoid Phenotype and Include a Subset Recognizing In Vivo Epitopes of Its γ Chain One of Which Is Not Cross Reactive With Anti-Citrullinated Protein Antibodies

Author

Brevet, Pauline, primary, Lattard, Claire, additional, Guillou, Clément, additional, Rottenberg, Pascal, additional, Fardellone, Patrice, additional, Le-Loët, Xavier, additional, Lequerré, Thierry, additional, Cosette, Pascal, additional, Boyer, Olivier, additional, Fréret, Manuel, additional, and Vittecoq, Olivier, additional

Published
2021
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9. Physiological and proteomic analyses of Tunisian local grapevine (Vitis vinifera) cultivar Razegui in response to drought stress.

Author

Azri, Wassim, Jardak, Rahma, Cosette, Pascal, Guillou, Clément, Riahi, Jawaher, and Mliki, Ahmed

Subjects
DROUGHTS, VITIS vinifera, GRAPES, AMINO acid metabolism, PROTEOMICS, CALVIN cycle, CARBOHYDRATE metabolism
Abstract

Drought is one of the major environmental constraints threatening viticulture worldwide. Therefore, it is critical to reveal the molecular mechanisms underlying grapevine (Vitis vinifera L.) drought stress tolerance useful to select new species with higher tolerance/resilience potentials. Drought-tolerant Tunisian local grapevine cultivar Razegui was exposed to water deficit for 16 days. Subsequent proteomic analysis revealed 49 differentially accumulated proteins in leaves harvested on the drought-stressed vines. These proteins were mainly involved in photosynthesis, stress defence, energy and carbohydrate metabolism, protein synthesis/turnover and amino acid metabolism. Physiological analysis revealed that reduction of photosynthesis under drought stress was attributed to the downregulation of the light-dependent reactions, Calvin cycle and key enzymes of the photorespiration pathway. The accumulation of proteins involved in energy and carbohydrate metabolism indicate enhanced need of energy during active stress acclimation. Accumulation of protein amino acids seems to play a protective role under drought stress due to their osmoprotectant and ROS scavenging potential. Reduced protein synthesis and turnover help plants preserving energy to fight drought stress. Proteins related to stress defence might scavenge ROS and transmit the ROS signal as an oxidative signal transducer in drought-stress signalling. All of these original results represent valuable information towards improving drought tolerance of grapevine and promoting sustainable viticulture under climate change conditions. Drought is a major abiotic constraints that will have a strong negative impact on Mediterranean viticulture. Proteomic analysis of drought-tolerant Tunisian local grapevine (Vitis vinifera L.) cultivar Razegui revealed that water deficit affected many proteins, particularly those involved in photosynthesis, stress defence, energy and carbohydrate metabolism, protein synthesis/turnover and amino acid metabolism. The results have expanded our knowledge of the mechanisms by which grapevines respond to drought and may assist in designing and developing more drought-tolerant grapevines in the future. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Additional file 1: Table S1. of Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors

Author

Marie-Laure Golinski, Vandhuick, Thibault, Derambure, Céline, Fréret, Manuel, Lecuyer, Matthieu, Guillou, Clément, Hiron, Martine, Boyer, Olivier, Loët, Xavier Le, Vittecoq, Olivier, and Lequerré, Thierry

Subjects
musculoskeletal diseases, skin and connective tissue diseases, humanities
Abstract

Clinical and biological characteristics of rheumatoid arthritis (RA) patients treated with adalimumab, etanercept or abatacept. (DOC 61 kb)

Published
2015
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13. Soluble alpha-enolase activates monocytes by CD14-dependent TLR4 signalling pathway and exhibits a dual function

Author

Guillou, Clément, primary, Fréret, Manuel, additional, Fondard, Emeline, additional, Derambure, Céline, additional, Avenel, Gilles, additional, Golinski, Marie-Laure, additional, Verdet, Mathieu, additional, Boyer, Olivier, additional, Caillot, Frédérique, additional, Musette, Philippe, additional, Lequerré, Thierry, additional, and Vittecoq, Olivier, additional

Published
2016
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14. Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors

Author

Golinski, Marie-Laure, primary, Vandhuick, Thibault, additional, Derambure, Céline, additional, Fréret, Manuel, additional, Lecuyer, Matthieu, additional, Guillou, Clément, additional, Hiron, Martine, additional, Boyer, Olivier, additional, Le Loët, Xavier, additional, Vittecoq, Olivier, additional, and Lequerré, Thierry, additional

Published
2015
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15. Prophylactic Injection of Recombinant Alpha-Enolase Reduces Arthritis Severity in the Collagen-Induced Arthritis Mice Model

Author

Guillou, Clément, primary, Derambure, Céline, additional, Fréret, Manuel, additional, Verdet, Mathieu, additional, Avenel, Gilles, additional, Golinski, Marie-Laure, additional, Sabourin, Jean-Christophe, additional, Loarer, François Le, additional, Adriouch, Sahil, additional, Boyer, Olivier, additional, Lequerré, Thierry, additional, and Vittecoq, Olivier, additional

Published
2015
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16. Le secret le mieux gardé du tennis.

Author

Guillou, Clément

Subjects
TENNIS players, TENNIS, ATTITUDE (Psychology)
Abstract

The article presents an opinion about hostility among tennis players within the world of professional tennis.

Published
2013

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