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Your search keyword '"Guimond, Jean V."' showing total 13 results
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13 results on '"Guimond, Jean V."'

2. Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells

Author

Yun, Tae Jin, Lee, Jun Seong, Machmach, Kawthar, Shim, Dahee, Choi, Junhee, Wi, Young Jin, Jang, Hyung Seok, Jung, In-Hyuk, Kim, Kyeongdae, Yoon, Won Kee, Miah, Mohammad Alam, Li, Bin, Chang, Jinsam, Bego, Mariana G., Pham, Tram N.Q., Loschko, Jakob, Fritz, Jörg Hermann, Krug, Anne B., Lee, Seung-Pyo, Keler, Tibor, Guimond, Jean V., Haddad, Elie, Cohen, Eric A., Sirois, Martin G., El-Hamamsy, Ismail, Colonna, Marco, Oh, Goo Taeg, Choi, Jae-Hoon, and Cheong, Cheolho

Published
2016
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3. Autologous humanized mouse models of iPSC-derived tumors allow for the evaluation and modulation of cancer-immune cell interactions

Author

Moquin-Beaudry, Gaël, primary, Benabdallah, Basma, additional, Maggiorani, Damien, additional, Le, Oanh, additional, Li, Yuanyi, additional, Colas, Chloé, additional, Raggi, Claudia, additional, Ellezam, Benjamin, additional, M’Callum, Marie-Agnès, additional, Dal Soglio, Dorothée, additional, Guimond, Jean V., additional, Paganelli, Massimiliano, additional, Haddad, Elie, additional, and Beauséjour, Christian, additional

Published
2021
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7. Flt3L-Mediated Expansion of Plasmacytoid Dendritic Cells Suppresses HIV Infection in Humanized Mice

Author

Pham, Tram N.Q., primary, Meziane, Oussama, additional, Miah, Mohammad Alam, additional, Volodina, Olga, additional, Colas, Chloé, additional, Béland, Kathie, additional, Li, Yuanyi, additional, Dallaire, Frédéric, additional, Keler, Tibor, additional, Guimond, Jean V., additional, Lesage, Sylvie, additional, Cheong, Cheolho, additional, Haddad, Élie, additional, and Cohen, Éric A., additional

Published
2019
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8. Immune Responses to Human Induced Pluripotent Stem Cells and their Derived Myogenic Progenitors Are Mediated by Different Mechanisms in Humanized Mice

Author

Benabdallah, Basma, primary, Désaulniers-Langevin, Cynthia, additional, Goyer, Marie-Lyn, additional, Colas, Chloé, additional, Maltais, Chantale, additional, Li, Yuanyi, additional, Guimond, Jean V., additional, Tremblay, Jacques P, additional, Haddad, Elie, additional, and Beauséjour, Christian, additional

Published
2019
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10. Conventional Dendritic Cells Impair Recovery after Myocardial Infarction

Author

Lee, Jun Seong, primary, Jeong, Se-Jin, additional, Kim, Sinai, additional, Chalifour, Lorraine, additional, Yun, Tae Jin, additional, Miah, Mohammad Alam, additional, Li, Bin, additional, Majdoubi, Abdelilah, additional, Sabourin, Antoine, additional, Keler, Tibor, additional, Guimond, Jean V., additional, Haddad, Elie, additional, Choi, Eui-Young, additional, Epelman, Slava, additional, Choi, Jae-Hoon, additional, Thibodeau, Jacques, additional, Oh, Goo Taeg, additional, and Cheong, Cheolho, additional

Published
2018
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11. Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain

Author

Asahchop, Eugene L., primary, Meziane, Oussama, additional, Mamik, Manmeet K., additional, Chan, Wing F., additional, Branton, William G., additional, Resch, Lothar, additional, Gill, M. John, additional, Haddad, Elie, additional, Guimond, Jean V., additional, Wainberg, Mark A., additional, Baker, Glen B., additional, Cohen, Eric A., additional, and Power, Christopher, additional

Published
2017
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12. Amplification of Adipogenic Commitment by VSTM2A

Author

Secco, Blandine, primary, Camiré, Étienne, additional, Brière, Marc-Antoine, additional, Caron, Alexandre, additional, Billong, Armande, additional, Gélinas, Yves, additional, Lemay, Anne-Marie, additional, Tharp, Kevin M., additional, Lee, Peter L., additional, Gobeil, Stéphane, additional, Guimond, Jean V., additional, Patey, Natacha, additional, Guertin, David A., additional, Stahl, Andreas, additional, Haddad, Élie, additional, Marsolais, David, additional, Bossé, Yohan, additional, Birsoy, Kivanc, additional, and Laplante, Mathieu, additional

Published
2017
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13. Conventional Dendritic Cells Impair Recovery after Myocardial Infarction.

Author

Jun Seong Lee, Se-Jin Jeong, Sinai Kim, Chalifour, Lorraine, Tae Jin Yun, Miah, Mohammad Alam, Bin Li, Majdoubi, Abdelilah, Sabourin, Antoine, Keler, Tibor, Guimond, Jean V., Haddad, Elie, Eui-Young Choi, Epelman, Slava, Jae-Hoon Choi, Thibodeau, Jacques, Goo Taeg Oh, and Cheolho Cheong

Subjects
*MYOCARDIAL infarction, *DENDRITIC cells, *MACROPHAGES, *INTERLEUKIN-1, *CYTOKINES
Abstract

Ischemic myocardial injury results in sterile cardiac inflammation that leads to tissue repair, two processes controlled by mononuclear phagocytes. Despite global burden of cardiovascular diseases, we do not understand the functional contribution to pathogenesis of specific cardiac mononuclear phagocyte lineages, in particular dendritic cells. To address this limitation, we used detailed lineage tracing and genetic studies to identify bona fide murine and human CD103+ conventional dendritic cell (cDC)1s, CD11b+ cDC2s, and plasmacytoid DCs (pDCs) in the heart of normal mice and immunocompromised NSG mice reconstituted with human CD34+ cells, respectively. After myocardial infarction (MI), the specific depletion of cDCs, but not pDCs, improved cardiac function and prevented adverse cardiac remodeling. Our results showed that fractional shortening measured after MI was not influenced by the absence of pDCs. Interestingly, however, depletion of cDCs significantly improved reduction in fractional shortening. Moreover, fibrosis and cell areas were reduced in infarcted zones. This correlated with reduced numbers of cardiac macrophages, neutrophils, and T cells, indicating a blunted inflammatory response. Accordingly, mRNA levels of proinflammatory cytokines IL-1β and IFN-γ were reduced. Collectively, our results demonstrate the unequivocal pathological role of cDCs following MI. [ABSTRACT FROM AUTHOR]

Published
2018
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