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1. Stochastic Directly-Follows Process Discovery Using Grammatical Inference

Author: Guizzardi, G, Santoro, F, Mouratidis, H, Soffer, P, Alkhammash, H, Polyvyanyy, A, Moffat, A, Guizzardi, G, Santoro, F, Mouratidis, H, Soffer, P, Alkhammash, H, Polyvyanyy, A, and Moffat, A
Abstract: Starting with a collection of traces generated by process executions, process discovery is the task of constructing a simple model that describes the process, where simplicity is often measured in terms of model size. The challenge of process discovery is that the process of interest is unknown, and that while the input traces constitute positive examples of process executions, no negative examples are available. Many commercial tools discover Directly-Follows Graphs, in which nodes represent the observable actions of the process, and directed arcs indicate execution order possibilities over the actions. We propose a new approach for discovering sound Directly-Follows Graphs that is grounded in grammatical inference over the input traces. To promote the discovery of small graphs that also describe the process accurately we design and evaluate a genetic algorithm that supports the convergence of the inference parameters to the areas that lead to the discovery of interesting models. Experiments over real-world datasets confirm that our new approach can construct smaller models that represent the input traces and their frequencies more accurately than the state-of-the-art technique. Reasoning over the frequencies of encoded traces also becomes possible, due to the stochastic semantics of the action graphs we propose, which, for the first time, are interpreted as models that describe the stochastic languages of action traces.
Published: 2024

2. Property Specification and Models for Risk: Towards Risk Propagation Graphs: Position Paper

Author: Nicoletti, S., M, Fumagalli, M., Lopuhaä, M.A., Moritz Hahn, E., Guizzardi, G., Stoelinga, M.I.A., Nicoletti, S., M, Fumagalli, M., Lopuhaä, M.A., Moritz Hahn, E., Guizzardi, G., and Stoelinga, M.I.A.
Abstract: SAFECOMP 2023, Contains fulltext : 297189.pdf (Publisher’s version ) (Open Access), Safety-critical infrastructures must operate safely and securely. Fault tree and attack tree analysis are widespread methods used to assess risks in these systems: fault trees (FTs) are requiredamong others-by the Federal Aviation Administration, the Nuclear Regulatory Commission, in the ISO26262 standard for autonomous driving and for software development in aerospace systems. Attack trees (ATs) are hierarchical diagrams that offer a flexible modelling language used to assess how systems can be attacked. ATs are widely employed both in industry and academia: they are referred to by many system engineering frameworks, e.g. UMLsec and SysMLsec, and are supported by industrial tools such as Isograph's AttackTree. In this paper we will briefly present advancements on logics for property specification on FTs and ATs and pitch the idea of an extended model that combines FTs and ATs: risk propagation graphs.
Published: 2023

3. Management of intracranial hypertension following traumatic brain injury: a best clinical practice adoption proposal for intracranial pressure monitoring and decompressive craniectomy. Joint statements by the Traumatic Brain Injury Section of the Italian Society of Neurosurgery (SINch) and the Neuroanesthesia and Neurocritical Care Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI)

Author: Iaccarino C., Lippa L., Munari M., Castioni C. A., Robba C., Caricato A., Pompucci A., Signoretti S., Zona G., Rasulo F. A., Aimar E., Amato S., Angileri F. F., Anile C., Assietti R., Baratto V., Barbanera A., Basile L., Battaglia R., Bellocchi S., Bertuccio A., Blanco S., Bolognini A., Boniferro B., Bordi L., Bortolotti C., Brandini V., Broger M., Brollo M., Caffarella D. D., Caggiano C., Cantisani P. L., Capone C., Cappelletto B., Capuano C., Carangelo B., Caruselli G., Chessa M. A., Chiara M., Chibbaro S., Cioffi V., Ciprianocecchi P., Colistra D., Conti C., Contratti F., Costella G. B., Cuoci A., D'Avella D., D'Ercole M., Deangelis M., Defalco R., de Luca G., de Marinis P., Del Vecchio C., Delfinis C., Denaro L., Deodato F., Desogus N., Disomma A., Domenicucci M., Dones F., Fina M., Fiori L., Fricia M., Gaetani P., Gazzeri R., Gentile M., Germano A., Ghadirpour R., Gianfreda C. D., Gigante N., Gigli R., Giorgetti J., Giusa M., Gravina U. G., Grippi L., Guida F., Guizzardi G., Iannuzzo G., Kropp M., Lattanzi L., Lucantoni D., Maffei L., Magliulo M., Marconi F., Marruzzo D., Martellotta N., Marton E., Maugeri R., Mauro G., Meli F., Menniti A., Merciadri P., Milanese L., Nardacci B., Nasi D., Orvieto P., Pacca P., Pansini G., Panzarasa G., Passanisi M., Pavesi G., Pizzoni C., Pulera F., Rapana A., Ricci A., Rispoli R., Rotondo M., Russo N., Santilli S., Scarano E., Schwarz A., Servadei F., Simonetti G., Stefini R., Talamonti G., Turrisi A., Valente V. M., Villa A., Vindigni M., Visocchi M., Vitali M., Wierzbicki V., Zambon G., Zanotti B., Zenga F., Alampi D., Alessandri F., Aloj F., Amigoni A., Aspide R., Bertuetti R., Betti V., Bilotta F., Bonato V., Bosco E., Brita M., Buscema G., Cafiero T., Cappuccio D., Caradonna M., Caria C. G., Casartelliliviero M., Ciritella P., Cirrincione S., Citerio G., Colelli S., Coletta F., Concordia L., Congedo E., Covotta M., Crimella F., Dall'Acqua G., De Cassai A., Defulviis S., Deperi E., Deana C., Delgaudio A., Denittis N., Dicolandrea S., Divezza F., Ferri F., Flocco R., Fontana C., Forastierimolinari A., Frangiosa A., Fumagalli P., Fuselli E., Garbarino M. M., Gelormini D., Geraci C., Geraldini F., Giacomucci A., Giampaoli V., Giorgetti D., Gritti P., Gualdani S., Iacovazzo C., Iermano C., Latronico N., Lugari S., Lusenti F., Maglione C., Magnoni S., Maiarota F., Malla M., Marchesi M., Martino C., Matteotti I., Mazzeo A. T., Morello G., Nardiello I., Paticchio F., Pegoli M., Perotti V., Piazzolla M., Picciafuochi F., Rachedi N., Radolovich D. K., Recchia A., Riccardi S., Romagnoli S., Sala S., Scafuro M. A., Sgarlata P., Soragni A., Stefani F., Stival E., Stofella G., Terranova F., Tinturini R., Togni T., Toto R., Trapani D., Tringali E., Tullo L., Valente A., Valeo T., Varelli G., Villani R., Zamacavicchi F., Zanello M., Zarrillo N., Zugni N., Iaccarino, C, Lippa, L, Munari, M, Castioni, C, Robba, C, Caricato, A, Pompucci, A, Signoretti, S, Zona, G, Rasulo, F, Aimar, E, Amato, S, Angileri, F, Anile, C, Assietti, R, Baratto, V, Barbanera, A, Basile, L, Battaglia, R, Bellocchi, S, Bertuccio, A, Blanco, S, Bolognini, A, Boniferro, B, Bordi, L, Bortolotti, C, Brandini, V, Broger, M, Brollo, M, Caffarella, D, Caggiano, C, Cantisani, P, Capone, C, Cappelletto, B, Capuano, C, Carangelo, B, Caruselli, G, Chessa, M, Chiara, M, Chibbaro, S, Cioffi, V, Ciprianocecchi, P, Colistra, D, Conti, C, Contratti, F, Costella, G, Cuoci, A, D'Avella, D, D'Ercole, M, Deangelis, M, Defalco, R, de Luca, G, de Marinis, P, Del Vecchio, C, Delfinis, C, Denaro, L, Deodato, F, Desogus, N, Disomma, A, Domenicucci, M, Dones, F, Fina, M, Fiori, L, Fricia, M, Gaetani, P, Gazzeri, R, Gentile, M, Germano, A, Ghadirpour, R, Gianfreda, C, Gigante, N, Gigli, R, Giorgetti, J, Giusa, M, Gravina, U, Grippi, L, Guida, F, Guizzardi, G, Iannuzzo, G, Kropp, M, Lattanzi, L, Lucantoni, D, Maffei, L, Magliulo, M, Marconi, F, Marruzzo, D, Martellotta, N, Marton, E, Maugeri, R, Mauro, G, Meli, F, Menniti, A, Merciadri, P, Milanese, L, Nardacci, B, Nasi, D, Orvieto, P, Pacca, P, Pansini, G, Panzarasa, G, Passanisi, M, Pavesi, G, Pizzoni, C, Pulera, F, Rapana, A, Ricci, A, Rispoli, R, Rotondo, M, Russo, N, Santilli, S, Scarano, E, Schwarz, A, Servadei, F, Simonetti, G, Stefini, R, Talamonti, G, Turrisi, A, Valente, V, Villa, A, Vindigni, M, Visocchi, M, Vitali, M, Wierzbicki, V, Zambon, G, Zanotti, B, Zenga, F, Alampi, D, Alessandri, F, Aloj, F, Amigoni, A, Aspide, R, Bertuetti, R, Betti, V, Bilotta, F, Bonato, V, Bosco, E, Brita, M, Buscema, G, Cafiero, T, Cappuccio, D, Caradonna, M, Caria, C, Casartelliliviero, M, Ciritella, P, Cirrincione, S, Citerio, G, Colelli, S, Coletta, F, Concordia, L, Congedo, E, Covotta, M, Crimella, F, Dall'Acqua, G, De Cassai, A, Defulviis, S, Deperi, E, Deana, C, Delgaudio, A, Denittis, N, Dicolandrea, S, Divezza, F, Ferri, F, Flocco, R, Fontana, C, Forastierimolinari, A, Frangiosa, A, Fumagalli, P, Fuselli, E, Garbarino, M, Gelormini, D, Geraci, C, Geraldini, F, Giacomucci, A, Giampaoli, V, Giorgetti, D, Gritti, P, Gualdani, S, Iacovazzo, C, Iermano, C, Latronico, N, Lugari, S, Lusenti, F, Maglione, C, Magnoni, S, Maiarota, F, Malla, M, Marchesi, M, Martino, C, Matteotti, I, Mazzeo, A, Morello, G, Nardiello, I, Paticchio, F, Pegoli, M, Perotti, V, Piazzolla, M, Picciafuochi, F, Rachedi, N, Radolovich, D, Recchia, A, Riccardi, S, Romagnoli, S, Sala, S, Scafuro, M, Sgarlata, P, Soragni, A, Stefani, F, Stival, E, Stofella, G, Terranova, F, Tinturini, R, Togni, T, Toto, R, Trapani, D, Tringali, E, Tullo, L, Valente, A, Valeo, T, Varelli, G, Villani, R, Zamacavicchi, F, Zanello, M, Zarrillo, N, Zugni, N, Iaccarino, C., Lippa, L., Munari, M., Castioni, C. A., Robba, C., Caricato, A., Pompucci, A., Signoretti, S., Zona, G., Rasulo, F. A., Aimar, E., Amato, S., Angileri, F. F., Anile, C., Assietti, R., Baratto, V., Barbanera, A., Basile, L., Battaglia, R., Bellocchi, S., Bertuccio, A., Blanco, S., Bolognini, A., Boniferro, B., Bordi, L., Bortolotti, C., Brandini, V., Broger, M., Brollo, M., Caffarella, D. D., Caggiano, C., Cantisani, P. L., Capone, C., Cappelletto, B., Capuano, C., Carangelo, B., Caruselli, G., Chessa, M. A., Chiara, M., Chibbaro, S., Cioffi, V., Ciprianocecchi, P., Colistra, D., Conti, C., Contratti, F., Costella, G. B., Cuoci, A., D'Avella, D., D'Ercole, M., Deangelis, M., Defalco, R., de Luca, G., de Marinis, P., Del Vecchio, C., Delfinis, C., Denaro, L., Deodato, F., Desogus, N., Disomma, A., Domenicucci, M., Dones, F., Fina, M., Fiori, L., Fricia, M., Gaetani, P., Gazzeri, R., Gentile, M., Germano, A., Ghadirpour, R., Gianfreda, C. D., Gigante, N., Gigli, R., Giorgetti, J., Giusa, M., Gravina, U. G., Grippi, L., Guida, F., Guizzardi, G., Iannuzzo, G., Kropp, M., Lattanzi, L., Lucantoni, D., Maffei, L., Magliulo, M., Marconi, F., Marruzzo, D., Martellotta, N., Marton, E., Maugeri, R., Mauro, G., Meli, F., Menniti, A., Merciadri, P., Milanese, L., Nardacci, B., Nasi, D., Orvieto, P., Pacca, P., Pansini, G., Panzarasa, G., Passanisi, M., Pavesi, G., Pizzoni, C., Pulera, F., Rapana, A., Ricci, A., Rispoli, R., Rotondo, M., Russo, N., Santilli, S., Scarano, E., Schwarz, A., Servadei, F., Simonetti, G., Stefini, R., Talamonti, G., Turrisi, A., Valente, V. M., Villa, A., Vindigni, M., Visocchi, M., Vitali, M., Wierzbicki, V., Zambon, G., Zanotti, B., Zenga, F., Alampi, D., Alessandri, F., Aloj, F., Amigoni, A., Aspide, R., Bertuetti, R., Betti, V., Bilotta, F., Bonato, V., Bosco, E., Brita, M., Buscema, G., Cafiero, T., Cappuccio, D., Caradonna, M., Caria, C. G., Casartelliliviero, M., Ciritella, P., Cirrincione, S., Citerio, G., Colelli, S., Coletta, F., Concordia, L., Congedo, E., Covotta, M., Crimella, F., Dall'Acqua, G., De Cassai, A., Defulviis, S., Deperi, E., Deana, C., Delgaudio, A., Denittis, N., Dicolandrea, S., Divezza, F., Ferri, F., Flocco, R., Fontana, C., Forastierimolinari, A., Frangiosa, A., Fumagalli, P., Fuselli, E., Garbarino, M. M., Gelormini, D., Geraci, C., Geraldini, F., Giacomucci, A., Giampaoli, V., Giorgetti, D., Gritti, P., Gualdani, S., Iacovazzo, C., Iermano, C., Latronico, N., Lugari, S., Lusenti, F., Maglione, C., Magnoni, S., Maiarota, F., Malla, M., Marchesi, M., Martino, C., Matteotti, I., Mazzeo, A. T., Morello, G., Nardiello, I., Paticchio, F., Pegoli, M., Perotti, V., Piazzolla, M., Picciafuochi, F., Rachedi, N., Radolovich, D. K., Recchia, A., Riccardi, S., Romagnoli, S., Sala, S., Scafuro, M. A., Sgarlata, P., Soragni, A., Stefani, F., Stival, E., Stofella, G., Terranova, F., Tinturini, R., Togni, T., Toto, R., Trapani, D., Tringali, E., Tullo, L., Valente, A., Valeo, T., Varelli, G., Villani, R., Zamacavicchi, F., Zanello, M., Zarrillo, N., and Zugni, N.
Subjects: medicine.medical_specialty, Decompressive Craniectomy, Consensus development conference, Decompressive craniectomy, Guideline, Traumatic brain injuries, Critical Care, Intracranial Pressure, medicine.medical_treatment, MEDLINE, Neurosurgery, Traumatic brain injurie, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Intensive care, Settore MED/41 - ANESTESIOLOGIA, Brain Injuries, Traumatic, medicine, Humans, Anesthesia, Intensive care medicine, Randomized Controlled Trials as Topic, business.industry, Neurointensive care, Evidence-based medicine, Italy, 030220 oncology & carcinogenesis, Intracranial pressure monitoring, Surgery, Neurology (clinical), Analgesia, Intracranial Hypertension, business, 030217 neurology & neurosurgery, Human
Abstract: No robust evidence is provided by literature regarding the management of intracranial hypertension following severe traumatic brain injury (TBI). This is mostly due to the lack of prospective randomized controlled trials (RCTs), the presence of studies containing extreme heterogeneously collected populations and controversial considerations about chosen outcome. A scientific society should provide guidelines for care management and scientific support for those areas for which evidence-based medicine has not been identified. However, RCTs in severe TBI have failed to establish intervention effectiveness, arising the need to make greater use of tools such as Consensus Conferences between experts, which have the advantage of providing recommendations based on experience, on the analysis of updated literature data and on the direct comparison of different logistic realities. The Italian scientific societies should provide guidelines following the national laws ruling the best medical practice. However, many limitations do not allow the collection of data supporting high levels of evidence for intracranial pressure (ICP) monitoring and decompressive craniectomy (DC) in patients with severe TBI. This intersociety document proposes best practice guidelines for this subsetting of patients to be adopted on a national Italian level, along with joint statements from "TBI Section" of the Italian Society of Neurosurgery (SINch) endorsed by the Neuroanesthesia and Neurocritical Care Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI). Presented here is a recap of recommendations on management of ICP and DC supported a high level of available evidence and rate of agreement expressed by the assemblies during the more recent consensus conferences, where members of both groups have had a role of active participants and supporters. The listed recommendations have been sent to a panel of experts consisting of the 107 members of the "TBI Section" of the SINch and the 111 members of the Neuroanesthesia and Neurocritical Care Study Group of the SIAARTI. The aim of the survey was to test a preliminary evaluation of the grade of predictable future adherence of the recommendations following this intersociety proposal. The following recommendations are suggested as representing best clinical practice, nevertheless, adoption of local multidisciplinary protocols regarding thresholds of ICP values, drug therapies, hemostasis management and perioperative care of decompressed patients is strongly recommended to improve treatment efficiency, to increase the quality of data collection and to provide more powerful evidence with future studies. Thus, for this future perspective a rapid overview of the role of the multimodal neuromonitoring in the optimal severe TBI management is also provided in this document. It is reasonable to assume that the recommendations reported in this paper will in future be updated by new observations arising from future trials. They are not binding, and this document should be offered as a guidance for clinical practice through an intersociety agreement, taking in consideration the low level of evidence.
Published: 2021

4. Management of intracranial hypertension following traumatic brain injury: A best clinical practice adoption proposal for intracranial pressure monitoring and decompressive craniectomy: Joint statements by the Traumatic Brain Injury Section of the Italian Society of Neurosurgery (SINch) and the Neuroanesthesia and Neurocritical Care Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI)

Author: Iaccarino, C, Lippa, L, Munari, M, Castioni, C, Robba, C, Caricato, A, Pompucci, A, Signoretti, S, Zona, G, Rasulo, F, Aimar, E, Amato, S, Angileri, F, Anile, C, Assietti, R, Baratto, V, Barbanera, A, Basile, L, Battaglia, R, Bellocchi, S, Bertuccio, A, Blanco, S, Bolognini, A, Boniferro, B, Bordi, L, Bortolotti, C, Brandini, V, Broger, M, Brollo, M, Caffarella, D, Caggiano, C, Cantisani, P, Capone, C, Cappelletto, B, Capuano, C, Carangelo, B, Caruselli, G, Chessa, M, Chiara, M, Chibbaro, S, Cioffi, V, Ciprianocecchi, P, Colistra, D, Conti, C, Contratti, F, Costella, G, Cuoci, A, D'Avella, D, D'Ercole, M, Deangelis, M, Defalco, R, de Luca, G, de Marinis, P, Del Vecchio, C, Delfinis, C, Denaro, L, Deodato, F, Desogus, N, Disomma, A, Domenicucci, M, Dones, F, Fina, M, Fiori, L, Fricia, M, Gaetani, P, Gazzeri, R, Gentile, M, Germano, A, Ghadirpour, R, Gianfreda, C, Gigante, N, Gigli, R, Giorgetti, J, Giusa, M, Gravina, U, Grippi, L, Guida, F, Guizzardi, G, Iannuzzo, G, Kropp, M, Lattanzi, L, Lucantoni, D, Maffei, L, Magliulo, M, Marconi, F, Marruzzo, D, Martellotta, N, Marton, E, Maugeri, R, Mauro, G, Meli, F, Menniti, A, Merciadri, P, Milanese, L, Nardacci, B, Nasi, D, Orvieto, P, Pacca, P, Pansini, G, Panzarasa, G, Passanisi, M, Pavesi, G, Pizzoni, C, Pulera, F, Rapana, A, Ricci, A, Rispoli, R, Rotondo, M, Russo, N, Santilli, S, Scarano, E, Schwarz, A, Servadei, F, Simonetti, G, Stefini, R, Talamonti, G, Turrisi, A, Valente, V, Villa, A, Vindigni, M, Visocchi, M, Vitali, M, Wierzbicki, V, Zambon, G, Zanotti, B, Zenga, F, Alampi, D, Alessandri, F, Aloj, F, Amigoni, A, Aspide, R, Bertuetti, R, Betti, V, Bilotta, F, Bonato, V, Bosco, E, Brita, M, Buscema, G, Cafiero, T, Cappuccio, D, Caradonna, M, Caria, C, Casartelliliviero, M, Ciritella, P, Cirrincione, S, Citerio, G, Colelli, S, Coletta, F, Concordia, L, Congedo, E, Covotta, M, Crimella, F, Dall'Acqua, G, De Cassai, A, Defulviis, S, Deperi, E, Deana, C, Delgaudio, A, Denittis, N, Dicolandrea, S, Divezza, F, Ferri, F, Flocco, R, Fontana, C, Forastierimolinari, A, Frangiosa, A, Fumagalli, P, Fuselli, E, Garbarino, M, Gelormini, D, Geraci, C, Geraldini, F, Giacomucci, A, Giampaoli, V, Giorgetti, D, Gritti, P, Gualdani, S, Iacovazzo, C, Iermano, C, Latronico, N, Lugari, S, Lusenti, F, Maglione, C, Magnoni, S, Maiarota, F, Malla, M, Marchesi, M, Martino, C, Matteotti, I, Mazzeo, A, Morello, G, Nardiello, I, Paticchio, F, Pegoli, M, Perotti, V, Piazzolla, M, Picciafuochi, F, Rachedi, N, Radolovich, D, Recchia, A, Riccardi, S, Romagnoli, S, Sala, S, Scafuro, M, Sgarlata, P, Soragni, A, Stefani, F, Stival, E, Stofella, G, Terranova, F, Tinturini, R, Togni, T, Toto, R, Trapani, D, Tringali, E, Tullo, L, Valente, A, Valeo, T, Varelli, G, Villani, R, Zamacavicchi, F, Zanello, M, Zarrillo, N, Zugni, N, Iaccarino C., Lippa L., Munari M., Castioni C. A., Robba C., Caricato A., Pompucci A., Signoretti S., Zona G., Rasulo F. A., Aimar E., Amato S., Angileri F. F., Anile C., Assietti R., Baratto V., Barbanera A., Basile L., Battaglia R., Bellocchi S., Bertuccio A., Blanco S., Bolognini A., Boniferro B., Bordi L., Bortolotti C., Brandini V., Broger M., Brollo M., Caffarella D. D., Caggiano C., Cantisani P. L., Capone C., Cappelletto B., Capuano C., Carangelo B., Caruselli G., Chessa M. A., Chiara M., Chibbaro S., Cioffi V., Ciprianocecchi P., Colistra D., Conti C., Contratti F., Costella G. B., Cuoci A., D'Avella D., D'Ercole M., Deangelis M., Defalco R., de Luca G., de Marinis P., Del Vecchio C., Delfinis C., Denaro L., Deodato F., Desogus N., Disomma A., Domenicucci M., Dones F., Fina M., Fiori L., Fricia M., Gaetani P., Gazzeri R., Gentile M., Germano A., Ghadirpour R., Gianfreda C. D., Gigante N., Gigli R., Giorgetti J., Giusa M., Gravina U. G., Grippi L., Guida F., Guizzardi G., Iannuzzo G., Kropp M., Lattanzi L., Lucantoni D., Maffei L., Magliulo M., Marconi F., Marruzzo D., Martellotta N., Marton E., Maugeri R., Mauro G., Meli F., Menniti A., Merciadri P., Milanese L., Nardacci B., Nasi D., Orvieto P., Pacca P., Pansini G., Panzarasa G., Passanisi M., Pavesi G., Pizzoni C., Pulera F., Rapana A., Ricci A., Rispoli R., Rotondo M., Russo N., Santilli S., Scarano E., Schwarz A., Servadei F., Simonetti G., Stefini R., Talamonti G., Turrisi A., Valente V. M., Villa A., Vindigni M., Visocchi M., Vitali M., Wierzbicki V., Zambon G., Zanotti B., Zenga F., Alampi D., Alessandri F., Aloj F., Amigoni A., Aspide R., Bertuetti R., Betti V., Bilotta F., Bonato V., Bosco E., Brita M., Buscema G., Cafiero T., Cappuccio D., Caradonna M., Caria C. G., Casartelliliviero M., Ciritella P., Cirrincione S., Citerio G., Colelli S., Coletta F., Concordia L., Congedo E., Covotta M., Crimella F., Dall'Acqua G., De Cassai A., Defulviis S., Deperi E., Deana C., Delgaudio A., Denittis N., Dicolandrea S., Divezza F., Ferri F., Flocco R., Fontana C., Forastierimolinari A., Frangiosa A., Fumagalli P., Fuselli E., Garbarino M. M., Gelormini D., Geraci C., Geraldini F., Giacomucci A., Giampaoli V., Giorgetti D., Gritti P., Gualdani S., Iacovazzo C., Iermano C., Latronico N., Lugari S., Lusenti F., Maglione C., Magnoni S., Maiarota F., Malla M., Marchesi M., Martino C., Matteotti I., Mazzeo A. T., Morello G., Nardiello I., Paticchio F., Pegoli M., Perotti V., Piazzolla M., Picciafuochi F., Rachedi N., Radolovich D. K., Recchia A., Riccardi S., Romagnoli S., Sala S., Scafuro M. A., Sgarlata P., Soragni A., Stefani F., Stival E., Stofella G., Terranova F., Tinturini R., Togni T., Toto R., Trapani D., Tringali E., Tullo L., Valente A., Valeo T., Varelli G., Villani R., Zamacavicchi F., Zanello M., Zarrillo N., Zugni N., Iaccarino, C, Lippa, L, Munari, M, Castioni, C, Robba, C, Caricato, A, Pompucci, A, Signoretti, S, Zona, G, Rasulo, F, Aimar, E, Amato, S, Angileri, F, Anile, C, Assietti, R, Baratto, V, Barbanera, A, Basile, L, Battaglia, R, Bellocchi, S, Bertuccio, A, Blanco, S, Bolognini, A, Boniferro, B, Bordi, L, Bortolotti, C, Brandini, V, Broger, M, Brollo, M, Caffarella, D, Caggiano, C, Cantisani, P, Capone, C, Cappelletto, B, Capuano, C, Carangelo, B, Caruselli, G, Chessa, M, Chiara, M, Chibbaro, S, Cioffi, V, Ciprianocecchi, P, Colistra, D, Conti, C, Contratti, F, Costella, G, Cuoci, A, D'Avella, D, D'Ercole, M, Deangelis, M, Defalco, R, de Luca, G, de Marinis, P, Del Vecchio, C, Delfinis, C, Denaro, L, Deodato, F, Desogus, N, Disomma, A, Domenicucci, M, Dones, F, Fina, M, Fiori, L, Fricia, M, Gaetani, P, Gazzeri, R, Gentile, M, Germano, A, Ghadirpour, R, Gianfreda, C, Gigante, N, Gigli, R, Giorgetti, J, Giusa, M, Gravina, U, Grippi, L, Guida, F, Guizzardi, G, Iannuzzo, G, Kropp, M, Lattanzi, L, Lucantoni, D, Maffei, L, Magliulo, M, Marconi, F, Marruzzo, D, Martellotta, N, Marton, E, Maugeri, R, Mauro, G, Meli, F, Menniti, A, Merciadri, P, Milanese, L, Nardacci, B, Nasi, D, Orvieto, P, Pacca, P, Pansini, G, Panzarasa, G, Passanisi, M, Pavesi, G, Pizzoni, C, Pulera, F, Rapana, A, Ricci, A, Rispoli, R, Rotondo, M, Russo, N, Santilli, S, Scarano, E, Schwarz, A, Servadei, F, Simonetti, G, Stefini, R, Talamonti, G, Turrisi, A, Valente, V, Villa, A, Vindigni, M, Visocchi, M, Vitali, M, Wierzbicki, V, Zambon, G, Zanotti, B, Zenga, F, Alampi, D, Alessandri, F, Aloj, F, Amigoni, A, Aspide, R, Bertuetti, R, Betti, V, Bilotta, F, Bonato, V, Bosco, E, Brita, M, Buscema, G, Cafiero, T, Cappuccio, D, Caradonna, M, Caria, C, Casartelliliviero, M, Ciritella, P, Cirrincione, S, Citerio, G, Colelli, S, Coletta, F, Concordia, L, Congedo, E, Covotta, M, Crimella, F, Dall'Acqua, G, De Cassai, A, Defulviis, S, Deperi, E, Deana, C, Delgaudio, A, Denittis, N, Dicolandrea, S, Divezza, F, Ferri, F, Flocco, R, Fontana, C, Forastierimolinari, A, Frangiosa, A, Fumagalli, P, Fuselli, E, Garbarino, M, Gelormini, D, Geraci, C, Geraldini, F, Giacomucci, A, Giampaoli, V, Giorgetti, D, Gritti, P, Gualdani, S, Iacovazzo, C, Iermano, C, Latronico, N, Lugari, S, Lusenti, F, Maglione, C, Magnoni, S, Maiarota, F, Malla, M, Marchesi, M, Martino, C, Matteotti, I, Mazzeo, A, Morello, G, Nardiello, I, Paticchio, F, Pegoli, M, Perotti, V, Piazzolla, M, Picciafuochi, F, Rachedi, N, Radolovich, D, Recchia, A, Riccardi, S, Romagnoli, S, Sala, S, Scafuro, M, Sgarlata, P, Soragni, A, Stefani, F, Stival, E, Stofella, G, Terranova, F, Tinturini, R, Togni, T, Toto, R, Trapani, D, Tringali, E, Tullo, L, Valente, A, Valeo, T, Varelli, G, Villani, R, Zamacavicchi, F, Zanello, M, Zarrillo, N, Zugni, N, Iaccarino C., Lippa L., Munari M., Castioni C. A., Robba C., Caricato A., Pompucci A., Signoretti S., Zona G., Rasulo F. A., Aimar E., Amato S., Angileri F. F., Anile C., Assietti R., Baratto V., Barbanera A., Basile L., Battaglia R., Bellocchi S., Bertuccio A., Blanco S., Bolognini A., Boniferro B., Bordi L., Bortolotti C., Brandini V., Broger M., Brollo M., Caffarella D. D., Caggiano C., Cantisani P. L., Capone C., Cappelletto B., Capuano C., Carangelo B., Caruselli G., Chessa M. A., Chiara M., Chibbaro S., Cioffi V., Ciprianocecchi P., Colistra D., Conti C., Contratti F., Costella G. B., Cuoci A., D'Avella D., D'Ercole M., Deangelis M., Defalco R., de Luca G., de Marinis P., Del Vecchio C., Delfinis C., Denaro L., Deodato F., Desogus N., Disomma A., Domenicucci M., Dones F., Fina M., Fiori L., Fricia M., Gaetani P., Gazzeri R., Gentile M., Germano A., Ghadirpour R., Gianfreda C. D., Gigante N., Gigli R., Giorgetti J., Giusa M., Gravina U. G., Grippi L., Guida F., Guizzardi G., Iannuzzo G., Kropp M., Lattanzi L., Lucantoni D., Maffei L., Magliulo M., Marconi F., Marruzzo D., Martellotta N., Marton E., Maugeri R., Mauro G., Meli F., Menniti A., Merciadri P., Milanese L., Nardacci B., Nasi D., Orvieto P., Pacca P., Pansini G., Panzarasa G., Passanisi M., Pavesi G., Pizzoni C., Pulera F., Rapana A., Ricci A., Rispoli R., Rotondo M., Russo N., Santilli S., Scarano E., Schwarz A., Servadei F., Simonetti G., Stefini R., Talamonti G., Turrisi A., Valente V. M., Villa A., Vindigni M., Visocchi M., Vitali M., Wierzbicki V., Zambon G., Zanotti B., Zenga F., Alampi D., Alessandri F., Aloj F., Amigoni A., Aspide R., Bertuetti R., Betti V., Bilotta F., Bonato V., Bosco E., Brita M., Buscema G., Cafiero T., Cappuccio D., Caradonna M., Caria C. G., Casartelliliviero M., Ciritella P., Cirrincione S., Citerio G., Colelli S., Coletta F., Concordia L., Congedo E., Covotta M., Crimella F., Dall'Acqua G., De Cassai A., Defulviis S., Deperi E., Deana C., Delgaudio A., Denittis N., Dicolandrea S., Divezza F., Ferri F., Flocco R., Fontana C., Forastierimolinari A., Frangiosa A., Fumagalli P., Fuselli E., Garbarino M. M., Gelormini D., Geraci C., Geraldini F., Giacomucci A., Giampaoli V., Giorgetti D., Gritti P., Gualdani S., Iacovazzo C., Iermano C., Latronico N., Lugari S., Lusenti F., Maglione C., Magnoni S., Maiarota F., Malla M., Marchesi M., Martino C., Matteotti I., Mazzeo A. T., Morello G., Nardiello I., Paticchio F., Pegoli M., Perotti V., Piazzolla M., Picciafuochi F., Rachedi N., Radolovich D. K., Recchia A., Riccardi S., Romagnoli S., Sala S., Scafuro M. A., Sgarlata P., Soragni A., Stefani F., Stival E., Stofella G., Terranova F., Tinturini R., Togni T., Toto R., Trapani D., Tringali E., Tullo L., Valente A., Valeo T., Varelli G., Villani R., Zamacavicchi F., Zanello M., Zarrillo N., and Zugni N.
Abstract: No robust evidence is provided by literature regarding the management of intracranial hypertension following severe traumatic brain injury (TBI). This is mostly due to the lack of prospective randomized controlled trials (RCTs), the presence of studies containing extreme heterogeneously collected populations and controversial considerations about chosen outcome. A scientific society should provide guidelines for care management and scientific support for those areas for which evidence-based medicine has not been identified. However, RCTs in severe TBI have failed to establish intervention effectiveness, arising the need to make greater use of tools such as Consensus Conferences between experts, which have the advantage of providing recommendations based on experience, on the analysis of updated literature data and on the direct comparison of different logistic realities. The Italian scientific societies should provide guidelines following the national laws ruling the best medical practice. However, many limitations do not allow the collection of data supporting high levels of evidence for intracranial pressure (ICP) monitoring and decompressive craniectomy (DC) in patients with severe TBI. This intersociety document proposes best practice guidelines for this subsetting of patients to be adopted on a national Italian level, along with joint statements from “TBI Section” of the Italian Society of Neurosurgery (SINch) endorsed by the Neuroanesthesia and Neurocritical Care Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI). Presented here is a recap of recommendations on management of ICP and DC supported a high level of available evidence and rate of agreement expressed by the assemblies during the more recent consensus conferences, where members of both groups have had a role of active participants and supporters. The listed recommendations have been sent to a panel of experts consisting of the 107 members of the “T
Published: 2021

5. The application of information technology to diagnose postharvest diseases of apple

Author: Baric, S, Guizzardi, G, Stella, F, Zanker, M, Baric S., Guizzardi G., Stella F., Zanker M., Baric, S, Guizzardi, G, Stella, F, Zanker, M, Baric S., Guizzardi G., Stella F., and Zanker M.
Abstract: South Tyrol (northern Italy) produces around one million metric tons of apple fruit annually and contributes to almost 10% of the European apple harvest. Despite the availability of advanced storage technologies, postharvest diseases of apple may lead to the deterioration of quality and losses of fruit not only during the storage process but also in the course of packing, shipment and shelf-life. In order to decide on a strategy for damage control or to implement plant protection programs, it is crucially important to reliably determine the nature of plant diseases. Apart from the observation of macroscopic symptoms and the application of laboratory-dependent microscopic, microbiological and molecular methods, a variety of novel approaches for the detection of plant diseases and pathogens is being developed. The present study focuses on the potential of information technology to bring the diagnosis process closer to practitioners. Particular attention is paid to the application of computer vision techniques and use of decision support systems. We provide a review of existing implementations of computer-based tools to diagnose plant diseases and present an outline of the “DSSApple” research project, which focuses on the development of a decision support system for the determination of postharvest diseases of apples.
Published: 2021

6. FAIR Digital Twins for Data-Intensive Research

Author: Schultes, E., Roos, M., Santos, L.O.B.D., Guizzardi, G., Bouwman, J., Hankemeier, T., Baak, A., Mons, B., Services, Cybersecurity & Safety, and Digital Society Institute
Subjects: machine learning, Artificial Intelligence, Computer Science (miscellaneous), data stewardship, Knowlet, augmented reasoning, FAIR Digital Object, FAIR Digital Twin, FAIR guiding principles, Information Systems, nanopublications
Abstract: Although all the technical components supporting fully orchestrated Digital Twins (DT) currently exist, what remains missing is a conceptual clarification and analysis of a more generalized concept of a DT that is made FAIR, that is, universally machine actionable. This methodological overview is a first step toward this clarification. We present a review of previously developed semantic artifacts and how they may be used to compose a higher-order data model referred to here as a FAIR Digital Twin (FDT). We propose an architectural design to compose, store and reuse FDTs supporting data intensive research, with emphasis on privacy by design and their use in GDPR compliant open science.
Published: 2022

7. Preface

Author: Almeida, João Paulo A., Guizzardi, Giancarlo, Maggi, Fabrizio Maria, Karastoyanova, Dimka, Montali, Marco, Fonseca, Claudenir M., Almeida, J.P.A., Karastoyanova, D., Guizzardi, G., Fonseca, C.M., Montali, M., Maggi, F.M., and Information Systems
Published: 2022

8. Aneurysm Rests in a Surgical Series of 275 Patients (Five Years): Incidence, Prognostic and Therapeutic Implications

Author: Mennonna, Pasquale, Ammannati, F., Bordi, L., Cagnoni, G., Gagliardi, R., Guizzardi, G. C, Mariotti, F., Morichi, R., Pasqualin, Alberto, editor, and Da Pian, Renato, editor
Published: 1994
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9. Representing a reference foundational ontology of events in

Author: Botti Benevides, A, Bourguet, J, Guizzardi, G, Penaloza, R, Almeida, J, Botti Benevides A., Bourguet J. -R., Guizzardi G., Penaloza R., Almeida J. P. A., Botti Benevides, A, Bourguet, J, Guizzardi, G, Penaloza, R, Almeida, J, Botti Benevides A., Bourguet J. -R., Guizzardi G., Penaloza R., and Almeida J. P. A.
Abstract: In recent years, there has been a growing interest in the application of foundational ontologies, i.e., formal ontological theories in the philosophical sense, to provide a theoretically sound foundation for improving the theory and practice of conceptual modeling and knowledge representation. This paper addresses one particular foundational theory of events termed UFO-B, which has been successfully employed as a reference model for addressing problems from complex media management, enterprise architecture, software engineering, and modeling of events in petroleum exploration. Despite its success, there is still no formalization of UFO-B in a decidable knowledge representation language that could support reasoning about complex events and event relations. We address this gap by proposing a number of alternative translations from UFO-B's original axiomatization (in first-order logic and in the Alloy formal language) to the description logic SROIQ, which is the formal underpinning of OWL 2 DL. Additionally, to support practical applications, we translated these SROIQ theories to OWL 2 DL TBoxes, which were validated by showing that all the intended models of UFO-B (the logical models of the UFO-B specification in Alloy) that we generated are consistent with these UFO-B TBoxes. In a sense, the specification in Alloy implements the specification in first-order logic, while the OWL 2 TBoxes implement the SROIQ specifications. Incidentally, the methodology that we designed for the translation from UFO-B's original axiomatization in FOL and Alloy to SROIQ came to be a key contribution of this work by providing us evidence of the inadequacy of DLs for the specification of comprehensive foundational ontologies.
Published: 2019

10. Thromboxane and prostacyclin biosynthesis in heart failure of ischemic origin: effects of disease severity and aspirin treatment

Author: SANTILLI, F., DAVÌ, G., BASILI, S., LATTANZIO, S., CAVONI, A., GUIZZARDI, G., DE FEUDIS, L., TRAISCI, G., PETTINELLA, C., PALOSCIA, L., MINUZ, P., MENEGUZZI, A., CIABATTONI, G., and PATRONO, C.
Published: 2010
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11. The application of information technology to diagnose postharvest diseases of apple

Author: Baric, S., primary, Guizzardi, G., additional, Stella, F., additional, and Zanker, M., additional
Published: 2021
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12. An overview of ontologies and tool support for COVID-19 analytics

Author: Ahmad, A., Bandara, M., Fahmideh, M., Proper, H.A., Guizzardi, G., Soar, J., Ahmad, A., Bandara, M., Fahmideh, M., Proper, H.A., Guizzardi, G., and Soar, J.
Abstract: Context: The outbreak of the SARS-CoV-2 pandemic of the new COVID-19 disease (COVID-19 for short) demands empowering existing medical, economic, and social emergency backend systems with data analytics capabilities. An impediment in taking advantages of data analytics in these systems is the lack of a unified framework or reference model. Ontologies are highlighted as a promising solution to bridge this gap by providing a formal representation of COVID-19 concepts such as symptoms, infections rate, contact tracing, and drug modelling. Ontology-based solutions enable the integration of diverse data sources that leads to a better understanding of pandemic data, management of smart lockdowns by identifying pandemic hotspots, and knowledge-driven inference, reasoning, and recommendations to tackle surrounding issues.Objective: This study aims to investigate COVID-19 related challenges that can benefit from ontology-based solutions, analyse available tool support, and identify emerging challenges that impact research and development of ontologies for COVID-19. Moreover, reference architecture models are presented to facilitate the design and development of innovative solutions that rely on ontology-based solutions and relevant tool support to address a multitude of challenges related to COVID-19.Method: We followed the formal guidelines of systematic mapping studies and systematic reviews to identify a total of 56 solutions – published research on ontology models for COVID-19 – and qualitatively selected 10 of them for the review.Results: Thematic analysis of the investigated solutions pinpoints five research themes including telehealth, health monitoring, disease modelling, data intelligence, and drug modelling. Each theme is supported by tool(s) enabling automation and user-decision support. Furthermore, we present four reference architectures that can address recurring challenges towards the development of the next generation of ontology-based solutions for COVID-19 a
Published: 2021

13. An Overview of Ontologies and Tool Support for COVID-19 Analytics

Author: Ahmad, A, Bandara, M, Fahmideh, M, Proper, HA, Guizzardi, G, Soar, J, Ahmad, A, Bandara, M, Fahmideh, M, Proper, HA, Guizzardi, G, and Soar, J
Abstract: Context: The outbreak of the SARS-CoV-2 pandemic of the new COVID-19 disease (COVID-19 for short) demands empowering existing medical, economic, and social emergency backend systems with data analytics capabilities. An impediment in taking advantages of data analytics in these systems is the lack of a unified framework or reference model. Ontologies are highlighted as a promising solution to bridge this gap by providing a formal representation of COVID-19 concepts such as symptoms, infections rate, contact tracing, and drug modelling. Ontology-based solutions enable the integration of diverse data sources that leads to a better understanding of pandemic data, management of smart lockdowns by identifying pandemic hotspots, and knowledge-driven inference, reasoning, and recommendations to tackle surrounding issues.Objective: This study aims to investigate COVID-19 related challenges that can benefit from ontology-based solutions, analyse available tool support, and identify emerging challenges that impact research and development of ontologies for COVID-19. Moreover, reference architecture models are presented to facilitate the design and development of innovative solutions that rely on ontology-based solutions and relevant tool support to address a multitude of challenges related to COVID-19.Method: We followed the formal guidelines of systematic mapping studies and systematic reviews to identify a total of 56 solutions - published research on ontology models for COVID-19 - and qualitatively selected 10 of them for the review.Results: Thematic analysis of the investigated solutions pinpoints five research themes including telehealth, health monitoring, disease modelling, data intelligence, and drug modelling. Each theme is supported by tool(s) enabling automation and user-decision support. Furthermore, we present four reference architectures that can address recurring challenges towards the development of the next generation of ontology-based solutions for COVID-19 a
Published: 2021

14. Degenerative lumbar spine stenosis consensus conference: The Italian job. Recommendations of the spinal section of the Italian society of neurosurgery

Author: Costa, F., Innocenzi, G., Guida, F., Agrillo, U., Barbagallo, G., Bocchetti, A., Bongetta, D., Cappelletto, B., Certo, F., Cimatti, M., Cioffi, V., Dobran, M., Domenicucci, M., Guizzardi, G., Landi, A., Marotta, N., Marzetti, F., Montano, Nicola, Anania, C. D., Nina, P., Quaglietta, P., Rispoli, R., Somma, T., Squillante, E., Visocchi, Massimiliano, Vitali, Mariateresa, Vitiello, V., Montano N. (ORCID:0000-0002-4965-1950), Visocchi M. (ORCID:0000-0003-1087-0491), Vitali M., Costa, F., Innocenzi, G., Guida, F., Agrillo, U., Barbagallo, G., Bocchetti, A., Bongetta, D., Cappelletto, B., Certo, F., Cimatti, M., Cioffi, V., Dobran, M., Domenicucci, M., Guizzardi, G., Landi, A., Marotta, N., Marzetti, F., Montano, Nicola, Anania, C. D., Nina, P., Quaglietta, P., Rispoli, R., Somma, T., Squillante, E., Visocchi, Massimiliano, Vitali, Mariateresa, Vitiello, V., Montano N. (ORCID:0000-0002-4965-1950), Visocchi M. (ORCID:0000-0003-1087-0491), and Vitali M.
Abstract: In the modern era evidence-based medicine, guidelines and recommendations represent a key-point of daily activity. The Spinal Section of the Italian Society of Neurosurgery introduced some recommendations regarding Degenerative Lumbar Spine Stenosis based on those of the Spine Committee of World Federation of Neurosurgical Societies, revising them on the basis of Italian common practice. In June 2019, a Committee of 21 spine surgeons met in Rome to validate the recommendations of the WFNS. Furthermore, they decided to review the ones that did not reach a consensus to create Italian Recommendations on Degenerative Lumbar Spine Stenosis. A literature review of the last ten years was performed and the statements were voted using the Delphi method. Forty-one statements were discussed, and 7 statements were voted again to reach a consensus with respect to those of the WFNS. A total of 40 statements reached a consensus, of which 36 reached a positive consensus and 4 a negative consensus, while no consensus was reached in 1 case. Conservative multimodal therapy, tailored on the patient, is a reasonable and effective first option choice for the treatment of LSS patients with tolerable moderate symptoms. Surgical treatment is reserved for symptomatic patients non-responding to conservative treatment or with neurological deficits. The best surgical technique to use depends on personal experience; modern MISS techniques are equivalent to open decompressive surgery with some advantages and higher cost-effectiveness. Fusion surgery and mobility preserving surgery only have a marginal role in the treatment of DLSS without instability.
Published: 2021

15. Management of intracranial hypertension following traumatic brain injury: A best clinical practice adoption proposal for intracranial pressure monitoring and decompressive craniectomy: Joint statements by the Traumatic Brain Injury Section of the Italian Society of Neurosurgery (SINch) and the Neuroanesthesia and Neurocritical Care Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI)

Author: Iaccarino, C., Lippa, L., Munari, M., Castioni, C. A., Robba, C., Caricato, Anselmo, Pompucci, Angelo, Signoretti, S., Zona, G., Rasulo, F. A., Aimar, E., Amato, S., Angileri, F. F., Anile, Carmelo, Assietti, R., Baratto, V., Barbanera, A., Basile, L., Battaglia, R., Bellocchi, S., Bertuccio, A., Blanco, S., Bolognini, A., Boniferro, B., Bordi, L., Bortolotti, C., Brandini, V., Broger, Maximilian, Brollo, M., Caffarella, D. D., Caggiano, Cinzia, Cantisani, P. L., Capone, C., Cappelletto, B., Capuano, C., Carangelo, B., Caruselli, G., Chessa, M. A., Chiara, M., Chibbaro, S., Cioffi, V., Ciprianocecchi, P., Colistra, D., Conti, C., Contratti, F., Costella, G. B., Cuoci, A., D'Avella, D., D'Ercole, Manuela, Deangelis, M., Defalco, R., de Luca, G., de Marinis, P., Del Vecchio, C., Delfinis, C., Denaro, Luca, Deodato, F., Desogus, N., Disomma, A., Domenicucci, M., Dones, F., Fina, M., Fiori, L., Fricia, M., Gaetani, P., Gazzeri, R., Gentile, M., Germano, A., Ghadirpour, R., Gianfreda, C. D., Gigante, N., Gigli, R., Giorgetti, J., Giusa, M., Gravina, U. G., Grippi, L., Guida, F., Guizzardi, G., Iannuzzo, G., Kropp, M., Lattanzi, L., Lucantoni, D., Maffei, L., Magliulo, M., Marconi, F., Marruzzo, D., Martellotta, N., Marton, E., Maugeri, R., Mauro, G., Meli, F., Menniti, A., Merciadri, P., Milanese, L., Nardacci, B., Nasi, D., Orvieto, P., Pacca, P., Pansini, G., Panzarasa, G., Passanisi, M., Pavesi, G., Pizzoni, C., Pulera, F., Rapana, A., Ricci, A., Rispoli, R., Rotondo, M., Russo, N., Santilli, S., Scarano, E., Schwarz, A., Servadei, Franco, Simonetti, G., Stefini, R., Talamonti, G., Turrisi, A., Valente, V. M., Villa, A., Vindigni, M., Visocchi, Massimiliano, Vitali, M., Wierzbicki, V., Zambon, G., Zanotti, B., Zenga, F., Alampi, D., Alessandri, F., Aloj, F., Amigoni, A., Aspide, R., Bertuetti, R., Betti, V., Bilotta, F., Bonato, V., Bosco, E., Brita, M., Buscema, G., Cafiero, T., Cappuccio, D., Caradonna, M., Caria, C. G., Casartelliliviero, M., Ciritella, P., Cirrincione, S., Citerio, G., Colelli, S., Coletta, F., Concordia, L., Congedo, E., Covotta, M., Crimella, F., Dall'Acqua, G., De Cassai, A., Defulviis, S., Deperi, E., Deana, C., Delgaudio, A., Denittis, N., Dicolandrea, S., Divezza, F., Ferri, F., Flocco, R., Fontana, C., Forastierimolinari, A., Frangiosa, A., Fumagalli, P., Fuselli, E., Garbarino, M. M., Gelormini, D., Geraci, C., Geraldini, F., Giacomucci, A., Giampaoli, V., Giorgetti, D., Gritti, P., Gualdani, S., Iacovazzo, C., Iermano, C., Latronico, N., Lugari, S., Lusenti, F., Maglione, C., Magnoni, S., Maiarota, F., Malla, M., Marchesi, M., Martino, C., Matteotti, I., Mazzeo, A. T., Morello, G., Nardiello, I., Paticchio, F., Pegoli, M., Perotti, Valerio, Piazzolla, M., Picciafuochi, F., Rachedi, N., Radolovich, D. K., Recchia, A., Riccardi, S., Romagnoli, S., Sala, S., Scafuro, M. A., Sgarlata, P., Soragni, A., Stefani, F., Stival, Eleonora, Stofella, G., Terranova, F., Tinturini, R., Togni, T., Toto, R., Trapani, D., Tringali, E., Tullo, L., Valente, A., Valeo, T., Varelli, G., Villani, R., Zamacavicchi, F., Zanello, M., Zarrillo, N., Zugni, N., Caricato A. (ORCID:0000-0001-5929-120X), Pompucci A. (ORCID:0000-0002-5427-9719), Anile C. (ORCID:0000-0002-0481-9713), Broger M., Caggiano C., D'Ercole M., Denaro L., Servadei F., Visocchi M. (ORCID:0000-0003-1087-0491), Perotti V. (ORCID:0000-0001-9461-2101), Stival E., Iaccarino, C., Lippa, L., Munari, M., Castioni, C. A., Robba, C., Caricato, Anselmo, Pompucci, Angelo, Signoretti, S., Zona, G., Rasulo, F. A., Aimar, E., Amato, S., Angileri, F. F., Anile, Carmelo, Assietti, R., Baratto, V., Barbanera, A., Basile, L., Battaglia, R., Bellocchi, S., Bertuccio, A., Blanco, S., Bolognini, A., Boniferro, B., Bordi, L., Bortolotti, C., Brandini, V., Broger, Maximilian, Brollo, M., Caffarella, D. D., Caggiano, Cinzia, Cantisani, P. L., Capone, C., Cappelletto, B., Capuano, C., Carangelo, B., Caruselli, G., Chessa, M. A., Chiara, M., Chibbaro, S., Cioffi, V., Ciprianocecchi, P., Colistra, D., Conti, C., Contratti, F., Costella, G. B., Cuoci, A., D'Avella, D., D'Ercole, Manuela, Deangelis, M., Defalco, R., de Luca, G., de Marinis, P., Del Vecchio, C., Delfinis, C., Denaro, Luca, Deodato, F., Desogus, N., Disomma, A., Domenicucci, M., Dones, F., Fina, M., Fiori, L., Fricia, M., Gaetani, P., Gazzeri, R., Gentile, M., Germano, A., Ghadirpour, R., Gianfreda, C. D., Gigante, N., Gigli, R., Giorgetti, J., Giusa, M., Gravina, U. G., Grippi, L., Guida, F., Guizzardi, G., Iannuzzo, G., Kropp, M., Lattanzi, L., Lucantoni, D., Maffei, L., Magliulo, M., Marconi, F., Marruzzo, D., Martellotta, N., Marton, E., Maugeri, R., Mauro, G., Meli, F., Menniti, A., Merciadri, P., Milanese, L., Nardacci, B., Nasi, D., Orvieto, P., Pacca, P., Pansini, G., Panzarasa, G., Passanisi, M., Pavesi, G., Pizzoni, C., Pulera, F., Rapana, A., Ricci, A., Rispoli, R., Rotondo, M., Russo, N., Santilli, S., Scarano, E., Schwarz, A., Servadei, Franco, Simonetti, G., Stefini, R., Talamonti, G., Turrisi, A., Valente, V. M., Villa, A., Vindigni, M., Visocchi, Massimiliano, Vitali, M., Wierzbicki, V., Zambon, G., Zanotti, B., Zenga, F., Alampi, D., Alessandri, F., Aloj, F., Amigoni, A., Aspide, R., Bertuetti, R., Betti, V., Bilotta, F., Bonato, V., Bosco, E., Brita, M., Buscema, G., Cafiero, T., Cappuccio, D., Caradonna, M., Caria, C. G., Casartelliliviero, M., Ciritella, P., Cirrincione, S., Citerio, G., Colelli, S., Coletta, F., Concordia, L., Congedo, E., Covotta, M., Crimella, F., Dall'Acqua, G., De Cassai, A., Defulviis, S., Deperi, E., Deana, C., Delgaudio, A., Denittis, N., Dicolandrea, S., Divezza, F., Ferri, F., Flocco, R., Fontana, C., Forastierimolinari, A., Frangiosa, A., Fumagalli, P., Fuselli, E., Garbarino, M. M., Gelormini, D., Geraci, C., Geraldini, F., Giacomucci, A., Giampaoli, V., Giorgetti, D., Gritti, P., Gualdani, S., Iacovazzo, C., Iermano, C., Latronico, N., Lugari, S., Lusenti, F., Maglione, C., Magnoni, S., Maiarota, F., Malla, M., Marchesi, M., Martino, C., Matteotti, I., Mazzeo, A. T., Morello, G., Nardiello, I., Paticchio, F., Pegoli, M., Perotti, Valerio, Piazzolla, M., Picciafuochi, F., Rachedi, N., Radolovich, D. K., Recchia, A., Riccardi, S., Romagnoli, S., Sala, S., Scafuro, M. A., Sgarlata, P., Soragni, A., Stefani, F., Stival, Eleonora, Stofella, G., Terranova, F., Tinturini, R., Togni, T., Toto, R., Trapani, D., Tringali, E., Tullo, L., Valente, A., Valeo, T., Varelli, G., Villani, R., Zamacavicchi, F., Zanello, M., Zarrillo, N., Zugni, N., Caricato A. (ORCID:0000-0001-5929-120X), Pompucci A. (ORCID:0000-0002-5427-9719), Anile C. (ORCID:0000-0002-0481-9713), Broger M., Caggiano C., D'Ercole M., Denaro L., Servadei F., Visocchi M. (ORCID:0000-0003-1087-0491), Perotti V. (ORCID:0000-0001-9461-2101), and Stival E.
Abstract: No robust evidence is provided by literature regarding the management of intracranial hypertension following severe traumatic brain injury (TBI). This is mostly due to the lack of prospective randomized controlled trials (RCTs), the presence of studies containing extreme heterogeneously collected populations and controversial considerations about chosen outcome. A scientific society should provide guidelines for care management and scientific support for those areas for which evidence-based medicine has not been identified. However, RCTs in severe TBI have failed to establish intervention effectiveness, arising the need to make greater use of tools such as Consensus Conferences between experts, which have the advantage of providing recommendations based on experience, on the analysis of updated literature data and on the direct comparison of different logistic realities. The Italian scientific societies should provide guidelines following the national laws ruling the best medical practice. However, many limitations do not allow the collection of data supporting high levels of evidence for intracranial pressure (ICP) monitoring and decompressive craniectomy (DC) in patients with severe TBI. This intersociety document proposes best practice guidelines for this subsetting of patients to be adopted on a national Italian level, along with joint statements from “TBI Section” of the Italian Society of Neurosurgery (SINch) endorsed by the Neuroanesthesia and Neurocritical Care Study Group of the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI). Presented here is a recap of recommendations on management of ICP and DC supported a high level of available evidence and rate of agreement expressed by the assemblies during the more recent consensus conferences, where members of both groups have had a role of active participants and supporters. The listed recommendations have been sent to a panel of experts consisting of the 107 members of the “T
Published: 2021

16. A core ontology on decision making

Author: Guizzardi, R., Carneiro, B. G., Daniele Porello, and Guizzardi, G.
Subjects: Foundational Ontology, Decision theory, Foundational Ontology, Decision theory
Published: 2020

17. O-013 - INTRAOPERATIVE NEUROPHYSIOLOGIC MONITORING OF OCULOMOTOR NERVES DURING ENDOSCOPIC SUPERIOR EYELID TRANSORBITAL SURGERY. PROOF OF CONCEPT AND ANATOMIC DEMONSTRATION

Author: Ferrés, A., Disomma, A., Reyes, L., Roldán, P., Guizzardi, G., Topzcewski, T., Mosteiro, A., Gómez, L., Codes, M., and Enseñat, J.
Published: 2023
Full Text: View/download PDF

18. O-008 - ENDOSCOPIC TRANSORBITAL APPROACH TO THE PETROUS APEX: IS LATERAL ORBITAL RIM REMOVAL WORTH FOR THE EXPOSURE?

Author: Mosteiro, A., Di Somma, A., Ferrés, A., Guizzardi, G., Topczewski, T.E., Reyes, L.A., Enseñat, J., and Prats-Galino, A.
Published: 2023
Full Text: View/download PDF

19. Thromboembolic complications or intracerebral haemorrhages in patients with atrial fibrillation in the emergency departments. Complications of atrial fibrillation in Bologna: the CAF-BO study: PB 1.63–6

Author: Cosmi, B, Salomone, L, Cavazza, M, Guizzardi, G, Binetti, N, Procaccianti, G, Puddu, G M, and Palareti, G
Published: 2013

20. Idiopatic Spinal Cord Herniation: A Treatable Cause of Brown-Séquard Syndrome

Author: Cellerini, M., Bayon, S., Scazzeri, F., Mangiafico, S., Amantini, A., Guizzardi, G. C., and Giordano, G. P.
Published: 2002
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21. Factors related to the length of in-hospital stay of geriatric patients

Author: Di Iorio, A., Longo, A., Mitidieri Costanza, A., Palmerio, T., Bcnvenuti, E., Giardini, S., Bavazzano, A., Guizzardi, G., Senin, U., Bandinelli, S., Ferrucci, L., and Abate, G.
Published: 1999
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22. Characteristics of geriatric patients related to early and late readmissions to hospital

Author: Di Iorio, A., Longo, A. L., Costanza, A. Mitidieri, Bandinelli, S., Capasso, S., Gigante, M., Bavazzano, A., Guizzardi, G., Senin, U., Ferrucci, L., and Abate, G.
Published: 1998
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23. Representing the UFO-B foundational ontology of events in SROIQ

Author: Janes A.,Penaloza R.,Jansen L.,Basile V.,Confalonieri R.,Vizedom A.,Porello D.,Borgo S.,Kutz O.,Gromann D.,Loebe F.,Herre H.,Hinterwaldner I.,Caselli T.,Colombo G.,Boeker M.,Stufano R.,Krois K.,Lieto A.,Daniele L.,Jansen L.,Schober D.,Sanfilippo E.M.,Galton A.,Antovic M.,Adrian K.,Neuhaus F.,Radicioni D.P.,Calvanese D.,Masolo C.,Hedblom M.M.,Euzenat J., Botti Benevides, A, Bourguet, J, Guizzardi, G, Penaloza, R, Botti Benevides A., Bourguet J. -R., Guizzardi G., Penaloza R., Janes A.,Penaloza R.,Jansen L.,Basile V.,Confalonieri R.,Vizedom A.,Porello D.,Borgo S.,Kutz O.,Gromann D.,Loebe F.,Herre H.,Hinterwaldner I.,Caselli T.,Colombo G.,Boeker M.,Stufano R.,Krois K.,Lieto A.,Daniele L.,Jansen L.,Schober D.,Sanfilippo E.M.,Galton A.,Antovic M.,Adrian K.,Neuhaus F.,Radicioni D.P.,Calvanese D.,Masolo C.,Hedblom M.M.,Euzenat J., Botti Benevides, A, Bourguet, J, Guizzardi, G, Penaloza, R, Botti Benevides A., Bourguet J. -R., Guizzardi G., and Penaloza R.
Abstract: In recent years, there has been a growing interest in the application of foundational ontologies, i.e., formal ontological theories in the philosophical sense, to provide a theoretically sound foundation for improving the theory and practice of conceptual modeling and knowledge representation. This paper addresses one particular foundational theory of events termed UFO-B, which has been successfully employed as a reference model for addressing problems from complex media management, enterprise architecture, software engineering, and modeling of events in petroleum exploration. Despite that, there is still no formalization of UFO-B in a decidable knowledge representation language that could support reasoning about complex events and event relations. We address this gap by proposing a number of alternative translations from UFO-B's original axiomatization (in first-order logic and in the Alloy formal language) to the description logic SROIQ, which is the formal underpinning of OWL 2 DL. Additionally, to support practical applications, we translated these SROIQ theories to OWL 2 DL TBoxes, which were validated by showing that all the intended models of UFO-B (the logical models of the UFO-B specification in Alloy) that we generated are consistent with these UFO-B TBoxes.
Published: 2017

24. Towards Understanding Aggressive Behavior in Residential Care Facilities Using Process Mining

Author: Koorn, J.J., Lu, X., Leopold, H., Reijers, H.A., Guizzardi, G., Gailly, F., Sub Process Management and Analytics, and Business Process Management and Analytics
Subjects: Process Mining, Healthcare, Taverne, aggressive behavior
Abstract: People with intellectual disabilities often live in residential care facilities that aim to provide their clients with the best possible quality of life. Aggressive behavior forms a threat to not only the quality of life of the clients, but also the safety of the staff. This study aims to uncover the dynamics underlying the evolution of aggressive behavior in people with intellectual disabilities. We take a process mining approach to analyze patterns of aggressive behavior. More specifically, we analyze data from 1,115 clients from a Dutch residential care facility over a period of three years. Our results show that there are two different groups of cases: those exclusively showing the same type of aggressive behavior and those who show mixed types of aggressive behavior. What stands out is that physical aggression towards other people plays a key role in the patterns of aggressive behavior. The results were validated with a behavioral expert from the care organization.
Published: 2019

25. On weak truthmaking

Author: Guarino, N., Daniele Porello, and Guizzardi, G.
Subjects: Ontological Analysis, Strong and Weak Truthmaking, Ontology, Weak truthmaking, Truthmaking
Abstract: Informally speaking, a truthmaker is something in the world in virtue of which the sentences of a language can be made true. This fundamental philosophical notion plays a central role in applied ontology. In particular, a recent nonorthodox formulation of this notion proposed by the philosopher Josh Parsons, which we labelled weak truthamking, has been shown to be extremely useful in addressing a number of classical problems in the area of Conceptual Modeling. In this paper, after revisiting the classical notion of truthmaking, we conduct an in depth analysis of Parsons' account of weak truthmaking. By doing that, we expose some difficulties in his original formulation. As the main contribution of this paper, we propose solutions to address these issues which are then integrated in a new precise interpretation of truthmaking that is harmonizable with commonsense as well as with existing four-category foundational ontologies.
Published: 2019

26. Capability Agreements and Risk

Author: Amaral, G. C. M., Guizzardi, G., Guarino, N., Daniele Porello, and Sales, T. P.
Subjects: Risk, Ontology, Capability, Vulnerability
Abstract: In this paper we analyse the ontological nature of capability agreements and discuss the relation between capability delegation, vulnerabilities and risk.
Published: 2019

27. Comparing traditional conceptual modeling with ontology-driven conceptual modeling: An empirical study

Author: Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació, Ghent University, Banque Nationale de Belgique, Verdonck, M., Gailly, F., Pergl, R., Guizzardi, G., Franco Martins, Beatriz, Pastor López, Oscar, Universitat Politècnica de València. Departamento de Sistemas Informáticos y Computación - Departament de Sistemes Informàtics i Computació, Ghent University, Banque Nationale de Belgique, Verdonck, M., Gailly, F., Pergl, R., Guizzardi, G., Franco Martins, Beatriz, and Pastor López, Oscar
Abstract: [EN] This paper conducts an empirical study that explores the differences between adopting a traditional conceptual modeling (TCM) technique and an ontology-driven conceptual modeling (ODCM) technique with the objective to understand and identify in which modeling situations an ODCM technique can prove beneficial compared to a TCM technique. More specifically, we asked ourselves if there exist any meaningful differences in the resulting conceptual model and the effort spent to create such model between novice modelers trained in an ontology-driven conceptual modeling technique and novice modelers trained in a traditional conceptual modeling technique. To answer this question, we discuss previous empirical research efforts and distill these efforts into two hypotheses. Next, these hypotheses are tested in a rigorously developed experiment, where a total of 100 students from two different Universities participated. The findings of our empirical study confirm that there do exist meaningful differences between adopting the two techniques. We observed that novice modelers applying the ODCM technique arrived at higher quality models compared to novice modelers applying the TCM technique. More specifically, the results of the empirical study demonstrated that it is advantageous to apply an ODCM technique over an TCM when having to model the more challenging and advanced facets of a certain domain or scenario. Moreover, we also did not find any significant difference in effort between applying these two techniques. Finally, we specified our results in three findings that aim to clarify the obtained results. (C) 2018 Elsevier Ltd. All rights reserved.
Published: 2019

28. What’s cracking? How image schema combinations can model conceptualisations of events

Author: Hedblom, M, Kutz, O, Penaloza, R, Guizzardi, G, Hedblom, MM, Hedblom, M, Kutz, O, Penaloza, R, Guizzardi, G, and Hedblom, MM
Abstract: Image schema profiles are described as clusters of spatiotemporal relationships learned from embodied experiences and function as the gathered conceptual information for event concepts. Looking at such profiles allows not only to model aspects of human conceptualisation but also offers a method to approach event conceptualisation for more formal purposes. This article investigates this research program by looking closer at how humans conceptualise events and specifies three combination methods of image schema profiles that each offer different aspects for concept construction. As a proof of concept, we present an in-depth analysis of the classic commonsense reasoning problem of ‘Cracking an Egg’ as a demonstration of how these profiles can be used in formal knowledge representation. This is formalised using the Image Schema Logic, ISLM, a combined logic targeted at the spatiotemporal relationships present in image schemas.
Published: 2019

29. Image Schema Combinations and Complex Events

Author: Hedblom, M, Kutz, O, Peñaloza, R, Guizzardi, G, Hedblom, Maria M., Kutz, Oliver, Peñaloza, Rafael, Guizzardi, Giancarlo, Hedblom, M, Kutz, O, Peñaloza, R, Guizzardi, G, Hedblom, Maria M., Kutz, Oliver, Peñaloza, Rafael, and Guizzardi, Giancarlo
Abstract: Formal knowledge representation struggles to represent the dynamic changes within complex events in a cognitively plausible way. Image schemas, on the other hand, are spatiotemporal relationships used in cognitive science as building blocks to conceptualise objects and events on a high level of abstraction. In this paper, we explore this modelling gap by looking at how image schemas can capture the skeletal information of events and describe segmentation cuts essential for conceptualising dynamic changes. The main contribution of the paper is the introduction of a more systematic approach for the combination of image schemas with one another in order to capture the conceptual representation of complex concepts and events. To reach this goal we use the image schema logic ISL, and, based on foundational research in cognitive linguistics and developmental psychology, we motivate three different methods for the formal combination of image schemas: merge, collection, and structured combination. These methods are then used for formal event segmentation where the changes in image-schematic state generate the points of separation into individual scenes. The paper concludes with a demonstration of our methodology and an ontological analysis of the classic commonsense reasoning problem of ‘cracking an egg’.
Published: 2019

30. Towards Understanding Aggressive Behavior in Residential Care Facilities Using Process Mining

Author: Sub Process Management and Analytics, Business Process Management and Analytics, Koorn, J.J., Lu, X., Leopold, H., Reijers, H.A., Guizzardi, G., Gailly, F., Sub Process Management and Analytics, Business Process Management and Analytics, Koorn, J.J., Lu, X., Leopold, H., Reijers, H.A., Guizzardi, G., and Gailly, F.
Published: 2019

31. Representing the UFO-B foundational ontology of events in SROIQ

Author: Botti Benevides A., Bourguet J. -R., Guizzardi G., Penaloza R., Janes A.,Penaloza R.,Jansen L.,Basile V.,Confalonieri R.,Vizedom A.,Porello D.,Borgo S.,Kutz O.,Gromann D.,Loebe F.,Herre H.,Hinterwaldner I.,Caselli T.,Colombo G.,Boeker M.,Stufano R.,Krois K.,Lieto A.,Daniele L.,Jansen L.,Schober D.,Sanfilippo E.M.,Galton A.,Antovic M.,Adrian K.,Neuhaus F.,Radicioni D.P.,Calvanese D.,Masolo C.,Hedblom M.M.,Euzenat J., Botti Benevides, A, Bourguet, J, Guizzardi, G, and Penaloza, R
Subjects: Knowledge representation, Ontology of event, Description logic, Formal ontology, OWL
Abstract: In recent years, there has been a growing interest in the application of foundational ontologies, i.e., formal ontological theories in the philosophical sense, to provide a theoretically sound foundation for improving the theory and practice of conceptual modeling and knowledge representation. This paper addresses one particular foundational theory of events termed UFO-B, which has been successfully employed as a reference model for addressing problems from complex media management, enterprise architecture, software engineering, and modeling of events in petroleum exploration. Despite that, there is still no formalization of UFO-B in a decidable knowledge representation language that could support reasoning about complex events and event relations. We address this gap by proposing a number of alternative translations from UFO-B's original axiomatization (in first-order logic and in the Alloy formal language) to the description logic SROIQ, which is the formal underpinning of OWL 2 DL. Additionally, to support practical applications, we translated these SROIQ theories to OWL 2 DL TBoxes, which were validated by showing that all the intended models of UFO-B (the logical models of the UFO-B specification in Alloy) that we generated are consistent with these UFO-B TBoxes.
Published: 2017

32. An OD pearl for the EE oyster

Author: Lekkerkerk, L.J., Aveiro, D., Pergl, R., Guizzardi, G., Almeida, J.P., Magalhães, R., Lekkerkerk, H., Aveiro, D., Pergl, R., Guizzardi, G., Almeida, J.P., Magalhães, R., and Lekkerkerk, H.
Subjects: Knowledge management, Computer science, business.industry, PEARL (programming language), Systems theory, Order (exchange), Systems design, Organizational structure, Enterprise engineering, business, computer, Institute for Management Research, computer.programming_language, Organizational functioning
Abstract: Explaining the basics of Lowlands-SocioTechnical Systems Design (L-STSD) to the Enterprise Engineering community is the first goal of this contribution in order to show how it fits with EE. Then, a first attempt is made to link L-STSD to basic EE insights gained so far. It seems that the commonalities are good, because of a shared basis in general systems theory, and a desire to optimize organizational functioning. The differences may not be problematic, so L-STSD may be a compliant view to enhance the EE-body of knowledge with a new lens on organisational structure, or the labour to be divided and coordinated & controlled.
Published: 2017

33. Ontological Foundations of Competition

Author: Sales T.P., Porello D., Guarino N., Guizzardi G., and Mylopoulos J.
Subjects: Conceptual Modelling, Competition, Economics, Ontology, Conceptual modeling
Abstract: It is widely recognized that accurately identifying and classifying competitors is a challenge for many companies and entrepreneurs. Nonetheless, it is a paramount activity which provide valuable insights that affect a wide range of strategic decisions. One of the main challenges in competitor identification lies in the complex nature of the competitive relationships that arise in business environments. These have been extensively investigate over the years, which lead to a plethora of competition theories and frameworks. Still, the concept of competition remains conceptually complex, as none of these approaches properly formalized their assumptions. In this paper, we address this issue by means of an ontological analysis on the notion of competition in general, and of business competition, in particular, leveraging theories from various fields, including Marketing, Strategic Management, Ecology, Psychology and Cognitive Sciences. Our analysis, the first of its kind in the literature, is grounded on the Unified Foundational Ontology (UFO) and allows us to formally characterize why competition arises, as well as to distinguish between three types of business competitive relationships, namely market-level, firm-level and potential competition.
Published: 2018

34. Under the Super-Suit: What Superheroes Can Reveal About Inherited properties in Conceptual Blending

Author: Guizzardi, G, Penaloza Nyssen, R, Hedblom, M, Kutz, O, Hedblom, MM, Guizzardi, G, Penaloza Nyssen, R, Hedblom, M, Kutz, O, and Hedblom, MM
Abstract: Conceptual blending has been proposed as the cognitive machinery for concept generation. While computational approaches to conceptual blending have been implemented with some success, the automatic approaches still struggle to consistently produce concepts and blends that ‘make sense’ and have value. Mechanisms and optimality principles for blending have been introduced, yet their formal integration remains sparse. In this paper, we suggest to partly bypass this problem by identifying some conceptual heuristics for blending. This is done through a top-down analysis of three prototypical superheroes, an exemplary domain for conceptual blends and human imagination. We formalise the superheroes and backtrace their properties into their respective input spaces and from there map the inherited properties to cognitive theories for conceptualisation. It is our belief that computational blending systems could greatly benefit from conceptual heuristics for blending, identified in this top-down fashion. As a proof of concept of the identified superhero-blending heuristics, we blend the superhero ‘Flowerman’.
Published: 2018

35. Intra-operative ultrasound of brain and spinal cord lesions

Author: Cellerini, M., Innocenti, P., Milazzotto, M., Bartolucci, M., Guizzardi, G., and Mennonna, P.
Published: 2001
Full Text: View/download PDF

36. Advances in Enterprise Engineering XI

Author: Aveiro, D., Pergl, R., Guizzardi, G., Almeida, J.P., Magalhães, R., and Lekkerkerk, L.J.
Subjects: Institute for Management Research
Abstract: Contains fulltext : 181816.pdf (Publisher’s version ) (Closed access) This book constitutes the proceedings of the 7th Enterprise Engineering Working Conference, EEWC 2017, held in Antwerp, Belgium, in May 2017. EEWC aims at addressing the challenges that modern and complex enterprises are facing in a rapidly changing world. The participants of the working conference share a belief that dealing with these challenges requires rigorous and scientific solutions, focusing on the design and engineering of enterprises. The goal of EEWC is to stimulate interaction between the different stakeholders, scientists as well as practitioners, interested in making Enterprise Engineering a reality. The 12 full papers and 4 short papers presented in this volume were carefully reviewed and selected from 40 submissions. They were organized in topical sections named: formalisms; standards and laws; business processes; normalized systems and evolvability; ontologies; and organization design. 235 p.
Published: 2017

37. Prevalence and Correlates of Behavioral Disorders in Old Age Subjects with Cognitive Impairment: Results from the ReGAl Project

Author: Boccardi, Virginia, Conestabile Della Staffa, Manuela, Baroni, Marta, Ercolani, Sara, Croce, Michele Francesco, Ruggiero, Carmelinda, Mecocci, Patrizia, Gabelli, C, Codemo, A, Marinelli, K, Capurso, A, Cucinotta, D, Reggiani, A, Ellena, L, Zanetti, O, Putzu, P, Del Prete, M, Spaccamento, S, Abate, G, Di Iorio, A, Cester, A, Formilan, M, Busonera, F, Anzivino, F, Masotti, G, Cavallini, C, Mossello, E, Odetti, P, Cataldi, Ag, Estraneo, A, Sica, G, Renna, S, Nicita-Mauro, V, Basile, G, Salvioli, G, Mussi, C, Ascari, S, Casale, R, Frazzitta, G, Scognamiglio, M, Di Palma, A, Rengo, F, Canonico, V, Fortunato, F, Enzi, G, Giordano, M, Vitrano Catania, T, Ferrari, E, Cuzzoni, G, Del Re ML, Guizzardi, G, Biagini, C, Bavazzano, A, Ferrari, A, Dallari, A, Carbonin, P, Bernabei, R, Silveri, Mc, Bartorelli, L, Gandolfi, B, Cerqua, R, Pilotto, A, Cascavilla, L, Chiaranti, A, Marinelli, M, Tripi, G, Gallucci, M, Marchetti, C, Masiello, V, Sacco, D, and Ricci, G.
Subjects: Male, Behavioral disturbances, cognitive impairment, dementia, old age, Settore M-PSI/02 - PSICOBIOLOGIA E PSICOLOGIA FISIOLOGICA, Behavioral Symptoms, Comorbidity, Severity of Illness Index, Sex Factors, Prevalence, Humans, Cognitive Dysfunction, Longitudinal Studies, Aged, Psychotropic Drugs, Age Factors, Clinical Psychology, Logistic Models, Socioeconomic Factors, Psychiatry and Mental Health, Female, Geriatrics and Gerontology, Factor Analysis, Statistical
Abstract: Presence of behavioral and psychological symptoms of dementia (BPSD) is very common in subjects with cognitive impairment, representing an important determinant of disease progression, institutionalization, and worse prognosis. Knowledge of the prevalence and correlates of BPSD in community-living old subjects with cognitive impairment is limited so far, but it is essential for establishing specifically tailored care and cure in such a vulnerable population.With this study, we aimed at investigating, in a large sample of old age subjects with cognitive impairment, BPSD prevalence and correlates including the main demographic, clinical, and socio-environmental characteristics.Data were gathered from the ReGAl project (Rete Geriatrica Alzheimer; Geriatric Network on Alzheimer's disease), a large longitudinal Italian multicentric clinical-based study, promoted by the Italian Society of Gerontology and Geriatrics (SIGG).We evaluated data from 4,157 old-age subjects affected by mild cognitive impairment (MCI) (541; 13%) or dementia (3616; 87%). 85.2% of all the population presented with at least one BPSD. Using a factor analysis, we identified four factors of BPSD: psychotic, affective, maniac, and impulse control behaviors. Logistic regression analyses revealed that among the main demographic, clinical, and socio-environmental aspects considered, only comorbidity was associated with all factors, independently of multiple covariates.Identification of BPSD is crucial in everyday clinical practice and necessary to develop specific interventions and to define appropriate outcomes in their management. BPSD occur in a complex psychopathological context, influenced by several demographic and environmental factors that must be taken into account for a correct diagnosis and treatment.
Published: 2017

38. Towards a first-order modal formalisation of the unified foundational ontology

Author: Daniele Porello and Guizzardi, G.
Subjects: Unified Foundational Ontlogy, Foundational ontologies, Ontology, Modal logic, First-order logic, Intension, Unified foundational ontology (UFO), Universals, First-order modal logic
Abstract: In this paper, we present a succinct formalisation of the main categories of the Unified Foundational Ontology (UFO) by summarising and simplifying a fragment of the version of [Gui05]. In this version, we show that the use first-order modal logic with no higher-order constructs suffices for many modelling tasks. We focus here on the case of universals.We slightly modify the original version of UFO by presenting new definitions of the intension and of the extension of universals and by approaching a taxonomy of universals.
Published: 2017

39. Alignment-Based Trace Clustering

Author: Chatain, T., Carmona, J., van Dongen, B.F., Mayr, H.C., Guizzardi, G., Ma, H., Pastor, O., Universitat Politècnica de Catalunya. Departament de Ciències de la Computació, Universitat Politècnica de Catalunya. ALBCOM - Algorismia, Bioinformàtica, Complexitat i Mètodes Formals, Process Science, Laboratoire Spécification et Vérification [Cachan] (LSV), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Modeling and Exploitation of Interaction and Concurrency (MEXICO), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Universitat Politècnica de Catalunya [Barcelona] (UPC), and Eindhoven University of Technology [Eindhoven] (TU/e)
Subjects: ACM: F.: Theory of Computation/F.4: MATHEMATICAL LOGIC AND FORMAL LANGUAGES, Similarity (geometry), Concept drift, Generalization, Computer science, Clustering approach, 02 engineering and technology, Solver, Anàlisi de conglomerats, Boolean domain, Cluster analysis, [INFO.INFO-FL]Computer Science [cs]/Formal Languages and Automata Theory [cs.FL], Informàtica::Informàtica teòrica [Àrees temàtiques de la UPC], Group log, 020204 information systems, Encoding (memory), Cluster event log, 0202 electrical engineering, electronic engineering, information engineering, Individual alignment problems, 020201 artificial intelligence & image processing, Algorithm, Model explanations, ACM: H.: Information Systems/H.3: INFORMATION STORAGE AND RETRIEVAL/H.3.3: Information Search and Retrieval/H.3.3.0: Clustering, TRACE (psycholinguistics)
Abstract: International audience; A novel method to cluster event log traces is presented in this paper. In contrast to the approaches in the literature, the clustering approach of this paper assumes an additional input: a process model that describes the current process. The core idea of the algorithm is to use model traces as centroids of the clusters detected, computed from a generalization of the notion of alignment. This way, model explanations of observed behavior are the driving force to compute the clusters, instead of current model agnostic approaches, e.g., which group log traces merely on their vector-space similarity. We believe alignment-based trace clustering provides results more useful for stakeholders. Moreover, in case of log incompleteness, noisy logs or concept drift, they can be more robust for dealing with highly deviating traces. The technique of this paper can be combined with any clustering technique to provide model explanations to the clusters computed. The proposed technique relies on encoding the individual alignment problems into the (pseudo-)Boolean domain, and has been implemented in our tool DarkSider that uses an open-source solver.
Published: 2017

40. The Prevalence of Diarrhea and Its Association With Drug Use in Elderly Outpatients: A Multicenter Study

Author: Pilotto, A, Franceschi, M, Vitale, D, Zaninelli, A, Di Mario, F, Seripa, D, Rengo, F, FIRI e. SOFIA Project Investigators, Barbagallo, M, Bavazzano, A, Bernabei, R, Biagini, C, Cucinotta, D, Guizzardi, G, Granchi, F, Laguzzi, E, Masotti, G, Maugeri, D, Mazzei, B, Nicìta, MV, Nieddu, A, Noro, G, Olivari, G, Palummeri, E, Policicchio, D, Postacchini, D, Putzu, P, Tardi, S, Abbiati, C, Alpa, A, Antiga, I, Antonina, MR, Arnaboldi, L, Ballotti, E, Bargellini, N, Barisone, G, Battelli, M, Beccari, G, Bitetti, E, Bologni, A, Bongera, P, Bortot, M, Bracalenti, L, Buonono, G, Busolo, M, Campanini, MC, Caputo, L, Cartei, A, Cascavilla, P, Casciaro, L, Casula, E, Cesarone, L, Chiesa, D, Chiumeo, F, Ciciarello, A, Cincotta, G, Corò, G, Corona, S, Corsini, M, Cosola, C, Dainese, A, Danza, M, De Bastiani, R, De Cesare, P, De Facci, G, De Lorenzo, R, De Vuono, AD, Della Piccola, P, D'Errico, G, Di Benedetto, G, Dodaro, M, Ercolino, M, Fatarella, P, Fazzari, F, Fiorese, G, Foco, G, Formicola, G, Franchi, F, Fronges, D, Gaetano, MA, Giordano, G, Guarino, M, Guasti, D, Kuel, AM, Kusanovic, M, Lanzavecchia, D, Lofiego, MC, Lorenzano, E, Losi, C, Magrini, F, Mancini, NM, Mander, A, Manneschi, M, Marchi, R, Maronato, G, Marsala, V, Mascia, R, Matuonto, V, Mauceri, ML, Mazzi, PA, Mezzapica, A, Mochi, F, Molenda, G, Morelli, F, Morsia, D, Mosna, MC, Muglia, A, Murgia, P, Muscetta, M, Muscetta, S, Nucci, P, Olimpi, G, Orro, W, Poletto, C, Palmieri, IP, Pastacaldi, G, Pastori, C, Pieresca, G, Pietragalla, M, Pilo, S, Poggesi, S, Poli, L, Ricciardi, A, Riggi, V, Romano, V, Rossi, T, Saccarello, A, Salatino, A, Salvati, R, Sannino, A, Santelli, M, Santucci, A, Saponaro, GM, Schergna, A, Schiavone, C, Sammarco, R, Scornavacca, G, Serena, D, Silvino, G, Sistilli, L, Soldan, S, Soro, A, Tatti, R, Tempestini, L, Testini, D, Tibeloli Carnevali, A, Toniolo, B, Torselli, R, Tremul, L, Trevisan, F, Trifilò, P, Cimenti, T, Valente, S, Vannucchi, CE, Vencato, PG, Vigotti, G, Virdis, G, Zaccaro, F, Zanzot, S, Zingone, FM, Zirillo, AM, ANNONI, GIORGIO, Pilotto, A, Franceschi, M, Vitale, D, Zaninelli, A, Di Mario, F, Seripa, D, Rengo, F, FIRI e., S, Annoni, G, Barbagallo, M, Bavazzano, A, Bernabei, R, Biagini, C, Cucinotta, D, Guizzardi, G, Granchi, F, Laguzzi, E, Masotti, G, Maugeri, D, Mazzei, B, Nicìta, M, Nieddu, A, Noro, G, Olivari, G, Palummeri, E, Policicchio, D, Postacchini, D, Putzu, P, Tardi, S, Abbiati, C, Alpa, A, Antiga, I, Antonina, M, Arnaboldi, L, Ballotti, E, Bargellini, N, Barisone, G, Battelli, M, Beccari, G, Bitetti, E, Bologni, A, Bongera, P, Bortot, M, Bracalenti, L, Buonono, G, Busolo, M, Campanini, M, Caputo, L, Cartei, A, Cascavilla, P, Casciaro, L, Casula, E, Cesarone, L, Chiesa, D, Chiumeo, F, Ciciarello, A, Cincotta, G, Corò, G, Corona, S, Corsini, M, Cosola, C, Dainese, A, Danza, M, De Bastiani, R, De Cesare, P, De Facci, G, De Lorenzo, R, De Vuono, A, Della Piccola, P, D'Errico, G, Di Benedetto, G, Dodaro, M, Ercolino, M, Fatarella, P, Fazzari, F, Fiorese, G, Foco, G, Formicola, G, Franchi, F, Fronges, D, Gaetano, M, Giordano, G, Guarino, M, Guasti, D, Kuel, A, Kusanovic, M, Lanzavecchia, D, Lofiego, M, Lorenzano, E, Losi, C, Magrini, F, Mancini, N, Mander, A, Manneschi, M, Marchi, R, Maronato, G, Marsala, V, Mascia, R, Matuonto, V, Mauceri, M, Mazzi, P, Mezzapica, A, Mochi, F, Molenda, G, Morelli, F, Morsia, D, Mosna, M, Muglia, A, Murgia, P, Muscetta, M, Muscetta, S, Nucci, P, Olimpi, G, Orro, W, Poletto, C, Palmieri, I, Pastacaldi, G, Pastori, C, Pieresca, G, Pietragalla, M, Pilo, S, Poggesi, S, Poli, L, Ricciardi, A, Riggi, V, Romano, V, Rossi, T, Saccarello, A, Salatino, A, Salvati, R, Sannino, A, Santelli, M, Santucci, A, Saponaro, G, Schergna, A, Schiavone, C, Sammarco, R, Scornavacca, G, Serena, D, Silvino, G, Sistilli, L, Soldan, S, Soro, A, Tatti, R, Tempestini, L, Testini, D, Tibeloli Carnevali, A, Toniolo, B, Torselli, R, Tremul, L, Trevisan, F, Trifilò, P, Cimenti, T, Valente, S, Vannucchi, C, Vencato, P, Vigotti, G, Virdis, G, Zaccaro, F, Zanzot, S, Zingone, F, and Zirillo, A
Subjects: Diarrhea, Drug, medicine.medical_specialty, Drug-Related Side Effects and Adverse Reactions, health care facilities, manpower, and services, media_common.quotation_subject, MEDLINE, Internal medicine, Outpatients, Prevalence, medicine, Humans, Psychiatry, Aged, media_common, Polypharmacy, Hepatology, business.industry, Gastroenterology, social sciences, humanities, Multicenter study, elderly outpatients, drug use, Diarrhea, MED/09 - MEDICINA INTERNA, medicine.symptom, business
Abstract: OBJECTIVES: To evaluate the prevalence of diarrhea and its association with drug use in elderly outpatients. METHODS: The study was carried out by 133 general practitioners (GPs) who referred to 24 geriatric units in Italy. The demographic data, disability, gastrointestinal symptoms, and current medications were evaluated using a structured interview, including the evaluation of the activities of daily living (ADL), the instrumental activities of daily living (IADL), and the gastrointestinal symptoms rating scale (GSRS). RESULTS: The study included 5,387 elderly subjects who regularly completed the structured interview. In total, 488 patients (9.1% of the whole population, 210 men and 278 women, mean age 75.6 6.2 yr, range 65–100 yr) reported diarrhea, that is, items 11 and 12 of the GSRS, during the 7-day period before the interview. The prevalence of diarrhea significantly increased with older age (P= 0.025), the severity of ADL (P < 0.0001) and IADL disability (P < 0.0001), and the number of drugs taken (P= 0.0002). A multivariate analysis demonstrated that the presence of diarrhea was significantly associated with the use of antibiotics (odds ratio [OR] 4.58, 95% confidence interval [CI] 1.95–10.73), proton pump inhibitors (OR 2.97, 95% CI 2.03–4.35), allopurinol (OR 2.19, 95% CI 1.26–3.81), psycholeptics (OR 1.82, 95% CI 1.26–2.61), selective serotonin reuptake inhibitors (OR 1.71, 95% CI 1.01–2.89), and angiotensin II receptor blockers (OR 1.46, 95% CI 1.08–1.99), also accounting for sex, age, and the use of antidiarrheal agents and drugs for functional gastrointestinal disorders. CONCLUSION: Diarrhea is a common problem in elderly outpatients. Its prevalence increases with old age, the severity of disability, and the number of drugs. Monitoring the presence of diarrhea and its complications in elderly patients who need treatments with drugs significantly associated with diarrhea may be clinically useful.
Published: 2008

41. Ontology-based modeling of cloud services: Challenges and perspectives

Author: Livieri, B., Nicola Guarino, Zappatore, M. S., Guizzardi, G., Longo, A., Bochicchio, M., Nardi, J. C., Barcellos, M. P., Quirino, G. K., Falbo, R. A., Livieri, Barbara, Guarino, N., Zappatore, MARCO SALVATORE, Guizzardi, G., Longo, Antonella, Bochicchio, Mario Alessandro, Nardi, J. C., Barcellos, M. P., Quirino, G. K., and Falbo, R. A.
Published: 2015

42. Traditionally vs sonographically coached pushing in second stage of labor: a pilot randomized controlled trial

Author: Bellussi, F., primary, Alcamisi, L., additional, Guizzardi, G., additional, Parma, D., additional, and Pilu, G., additional
Published: 2018
Full Text: View/download PDF

43. Drug use by the elderly in general practice: effects on upper gastrointestinal symptoms

Author: Pilotto, A, Franceschi, M, Vitale, D, Zaninelli, A, Masotti, G, Rengo, F, Barbagallo, M, Bavazzano, A, Bernabei, R, Biagini, C, Cucinotta, D, Guizzardi, G, Granchi, F, Laguzzi, E, Maugeri, D, Mazzei, B, Nicita, MV, Nieddu, A, Noro, G, Olivari, G, Palummeri, E, Policicchio, D, Postacchini, D, Putzu, P, Tardi, S., ANNONI, GIORGIO, Pilotto, A, Franceschi, M, Vitale, D, Zaninelli, A, Masotti, G, Rengo, F, Annoni, G, Barbagallo, M, Bavazzano, A, Bernabei, R, Biagini, C, Cucinotta, D, Guizzardi, G, Granchi, F, Laguzzi, E, Maugeri, D, Mazzei, B, Nicita, M, Nieddu, A, Noro, G, Olivari, G, Palummeri, E, Policicchio, D, Postacchini, D, Putzu, P, and Tardi, S
Subjects: Male, Drug Utilization, Drug, medicine.medical_specialty, Drug use, Elderly, Gastrointestinal symptoms, Pharmacoepidemiology, Activities of daily living, Drug-Related Side Effects and Adverse Reactions, Gastrointestinal Diseases, media_common.quotation_subject, Upper Gastrointestinal Tract, Sex Factors, Internal medicine, Activities of Daily Living, Epidemiology, Humans, Medicine, Upper gastrointestinal, Pharmacology (medical), Aged, media_common, Aged, 80 and over, Pharmacology, Polypharmacy, business.industry, Age Factors, social sciences, General Medicine, Pharmacoepidemiology, humanities, Surgery, Italy, General practice, Female, Family Practice, business
Abstract: Objective To evaluate the prevalence of drug use by elderly outpatients in Italy and to identify the association between drug use and gastrointestinal symptoms. Study design and setting The study was carried out by 133 general practitioners (GPs) who referred to 24 geriatric units in Italy. All consenting elderly patients seen at the GPs’ offices were evaluated for gender, age, disability, current medications, and upper gastrointestinal symptoms. Results The study included 5,515 elderly subjects. The prevalence of drug use was 91.6%, and the mean number of drugs taken was 2.86 per person. Both the prevalence and the mean number of drugs significantly increased with advancing age. Regarding gastrointestinal symptoms, 32.7% of patients reported at least one upper gastrointestinal symptom: 25% with indigestion syndrome, 16.2% with abdominal pain, and 14.2% with reflux symptoms. A significantly higher prevalence of symptoms was observed in females, patients who were taking a higher number of drugs, and those who had higher disability. Adjusted multivariate analysis demonstrated that the use of nonsteroidal antiinflammatory drugs, steroids, psycholeptics, diuretics, selective β2 adrenoreceptor agonists or adrenergics, and antiplatelet drugs was significantly associated with upper gastrointestinal symptoms. Conclusion The prevalence of drug use is very high in this elderly outpatient population. The number of drugs and the use of some specific drug classes are significantly associated with the presence of upper gastrointestinal symptoms.
Published: 2005

44. Upper gastrointestinal symptoms and therapies in elderly out-patients, users of non-selective NSAIDs or coxibs

Author: Pilotto, A, Franceschi, M, Vitale, DF, Zaninelli, A, Masotti, G, Rengo, F, Barbagallo, M, Bavazzano, A, Bernabei, R, Biagini, C, Cucinotta, D, Guizzardi, G, Granchi, F, Laguzzi, E, Maugeri, D, Mazzei, B, Nicita, MV, Nieddu, A, Noro, G, Olivari, G, Palummeri, E, Policicchio, D, Postacchini, D, Putzu, P, Tardi, S., ANNONI, GIORGIO, Pilotto, A, Franceschi, M, Vitale, D, Zaninelli, A, Masotti, G, Rengo, F, Annoni, G, Barbagallo, M, Bavazzano, A, Bernabei, R, Biagini, C, Cucinotta, D, Guizzardi, G, Granchi, F, Laguzzi, E, Maugeri, D, Mazzei, B, Nicita, M, Nieddu, A, Noro, G, Olivari, G, Palummeri, E, Policicchio, D, Postacchini, D, Putzu, P, and Tardi, S
Subjects: Male, Drug, medicine.medical_specialty, Gastrointestinal bleeding, Gastrointestinal Diseases, media_common.quotation_subject, Drug Prescriptions, Gastroenterology, Random Allocation, Gastrointestinal Agents, Ambulatory care, Internal medicine, Ambulatory Care, Humans, Medicine, Upper gastrointestinal, Cyclooxygenase Inhibitors, Pharmacology (medical), Medical prescription, Aged, media_common, Gastrointestinal agent, Hepatology, business.industry, Stomach, Anti-Inflammatory Agents, Non-Steroidal, medicine.disease, ADR, Elderly Patients, NSAID, medicine.anatomical_structure, Ambulatory, Female, Family Practice, business
Abstract: Summary Background: The association between coxib or non-steroidal anti-inflammatory drug use with gastrointestinal symptoms and drug prescriptions in ambulatory elderly patients is not well defined. Aim: To evaluate the association between non-steroidal anti-inflammatory drug NSAID and coxib use with gastrointestinal symptoms and therapies in elderly subjects managed by their general practitioner. Materials: The study was carried out by 133 general practitioners in Italy. By using a structured interview, sex, age, physical function, current medications, new drug prescriptions and upper gastrointestinal symptoms were registered from all elderly subjects who were referred to their general practitioners during a 2-week period. The numbers of hospitalizations, gastrointestinal bleeding events and gastrointestinal diagnostic procedures occurring during the last 6-month period were recorded. Results: Included in this study were 5515 elderly subjects. The overall prevalence of drug use was 92%. Musculo-skeletal drugs were taken by 15% of patients; NSAIDs were taken by 6%, and coxibs by 3% of patients. A significantly higher prevalence of upper gastrointestinal symptoms was observed in elderly NSAID users compared with coxib users and non-users of musculo-skeletal drugs (44% vs. 33% vs. 32% respectively, P = 0.001). The prescriptions of drugs for acid-related disorders were significantly higher in patients who were concomitantly taking NSAID rather than coxibs (13% vs. 6%, P
Published: 2005

45. Reviewer’s comment concerning “Surgical treatment of thoracic disc herniations via tailored posterior approaches” (doi:10.1007/s00586-011-1821-7 R1 by W. Börm et al.)

Author: Guizzardi, G.
Published: 2011
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46. An OD pearl for the EE oyster

Author: Aveiro, D., Pergl, R., Guizzardi, G., Almeida, J.P., Magalhães, R., Lekkerkerk, H., Lekkerkerk, L.J., Aveiro, D., Pergl, R., Guizzardi, G., Almeida, J.P., Magalhães, R., Lekkerkerk, H., and Lekkerkerk, L.J.
Abstract: Advances in Enterprise Engineering XI: 7th Enterprise Engineering Working Conference, Antwerp, Belgium, Contains fulltext : 201381.pdf (publisher's version ) (Closed access)
Published: 2017

47. PROVE DI LOTTA CONTRO IL RAGNO ROSSO DEGLI ALBERI DA FRUTTO

Author: Bargioni, G., Guizzardi, G., and Maccanti, M.
Published: 1952

48. Towards a Service Ontology Pattern Language

Author: Quirino G and Nardi J and Barcelos M and Falbo R and Guizzardi G and Longo A and GUARINO N. and Bochicchio M and Zappatore M and Livieri B
Subjects: ontology pattern languages, Services, ontology patterns
Abstract: In this paper we partially present an initial version of an Ontology Pattern Language, called S-OPL, describing the core conceptualization of serv- ices as a network of interconnected ontology modeling patterns. S-OPL builds on a commitment-based core ontology for services (UFO-S) and has been developed to support the engineering of ontologies involving services in different domains. S-OPL patterns address problems related to the distinction of general kinds of customers and providers, service offering, service negotiation and service delivery. In this paper, we focus on the first two. The use of S-OPL is demonstrated in a real case study in the domain of Information and Communication Technology services.
Published: 2015

49. An ontology-based well-founded proposal for modeling resources and capabilities in ArchiMate

Author: Azevedo, Carlos L.B., Iacob, Maria Eugenia, Andrade Almeida, João, van Sinderen, Marten J., Ferreira Pires, Luis, Guizzardi, G., Gasevic, D, Hatala, M., Motahari Nezhad, H.R., and Reichert, M.U.
Subjects: Resource, Knowledge management, Process management, business.industry, Computer science, Business data processing, Enterprise architecture, EWI-23827, ArchiMate, IR-88240, Modelling, METIS-300079, Capability, Ontology, Strategic management, Project portfolio management, business, Ontology-based Semantics, Competence (human resources), SCS-Services, Enterprise Architecture
Abstract: The importance of capabilities and resources for portfolio management and business strategy has been recognized in the management literature and on a recent proposal to extend ArchiMate, which includes these concepts in order to improve ArchiMate’s coverage of portfolio management. This paper presents an ontological analysis of the concepts introduced in that proposal, focusing in particular on the resource, capability and competence concepts. As a result, it proposes well-founded recommendations for improvements, enhancing its suitability and integration possibilities.
Published: 2013

50. Using a foundational ontology to investigate the semantics behind the concepts of the i* language

Author: Guizzardi-Silva Souza, R., Franch, Xavier, Guizzardi, G., Wieringa, Roelf J., Castro, J., Horkhoff, J., Maiden, N., and Yu, E.
Subjects: Foundational Ontology, METIS-300056, UFO, IR-87986, EWI-23794, language interoperability, SCS-Services, iStar, Semantics
Abstract: In the past few years, the community that develops i* has become aware of the problem of having so many variants, since it makes it difficult for newcomers to learn how to use the language and even to experts to efficiently exchange knowledge and disseminate their proposals. Moreover, this problem also delays the transfer of the i* framework to industrial settings. Our work is one of the current attempts to promote interoperability among the existing variants, and it does that by investigating the semantics behind the i* core concepts. For that, we apply a foundational ontology named UFO, which is used as a semantically coherent reference model to which the language should be isomorphic. In this paper, we report on the steps we have pursued, what we have accomplished so far, also setting the context for the work ahead.
Published: 2013

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