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8. Foreword

Author

GULLINI, S. and NORTHFIELD, T.

Published
2000

16. Mesalazine foam (Salofalk foam) in the treatment of active distal ulcerative colitis. A comparative trial vs Salofalk enema. The SAF-3 study group

Author

Ardizzone, S, Doldo, P, Ranzi, T, Sturniolo, Giacomo, Giglio, La, Annese, V, D'Arienzo, A, Gaia, E, Gullini, S, Riegler, G, Valentini, M, Massa, P, DEL PIANO, M, Rossini, F, Guidetti, Cs, Pera, A, Greinwald, R, Porro, G. B., Ardizzone, S, Doldo, P, Ranzi, T, Sturniolo, Gc, Giglio, La, Annese, V, D'Arienzo, Agesilao, Gaia, E, Gullini, S, Riegler, G, Valentini, M, Massa, P, Del Piano, M, Rossini, F, Guidetti, C, Pera, A, Greinwald, R, Bianchi Porro, G., D'Arienzo, A, Riegler, Gabriele, DEL PIANO, M, and Porro, Gb

Subjects
Adult, Male, mesalazine foam, INFLAMMATORY BOWEL-DISEASE, Administration, Topical, Enema, SAF-3 study group, Proctocolitis, THERAPY, Endoscopy, Gastrointestinal, ulcerative coliti, MANAGEMENT, 5-AMINOSALICYLIC ACID ENEMAS, Humans, Proctitis, Mesalamine, METAANALYSIS, ulcerative colitis, Cross-Over Studies, treatment, Anti-Inflammatory Agents, Non-Steroidal, REMISSION, mesalazine, rectal foam, topical treatment, ulcerative colitis, 5-AMINOSALICYLIC ACID ENEMAS, INFLAMMATORY BOWEL-DISEASE, METAANALYSIS, MANAGEMENT, REMISSION, THERAPY, topical treatment, Patient Satisfaction, mesalazine, Patient Compliance, Colitis, Ulcerative, Female, comparative trial, rectal foam
Abstract

Mesalazine enemas are of well proven efficacy for the topical treatment of distal ulcerative colitis. Although new rectal formulations of mesalazine are not expected to be superior in efficacy and tolerability to standard formulations, they may offer secondary advantages in terms of overall acceptability.To compare the efficacy, tolerability and overall acceptability of a new mesalazine rectal foam (Salofalk foam) with mesalazine enema in the treatment of active distal ulcerative colitis.A multicentre study was carried out in patients with active proctitis, proctosigmoiditis and left-sided ulcerative colitis as evaluated by the Clinical Activity Index (CAIor =4) and Endoscopic Index (EIor =6). Patients were randomly assigned to receive, in open-label fashion, either mesalazine foam 2 g twice a day or mesalazine enema (2 g/60 ml twice a day) for 3 weeks. Patients who did not achieve remission (defined as CAI4 and EI6) after 3 weeks continued the study receiving the alternative galenic formulation for a further 3 weeks.A total of 195 patients were enrolled. Characteristics at baseline were similar except for concomitant therapy with oral 5-ASA products: during the 1st treatment phase, 41% of patients on enema received such treatment vs only 29% of those on foam. Patients with at least one post-treatment efficacy evaluation were included in the intent-to-treat analysis (n=89 foam, n=96 enema). After 3 weeks of treatment, 112 patients were in remission and only 59 patients entered the 2nd treatment phase thus providing data on acceptability. Remission was achieved after 3 weeks in 54% of patients treated with foam and in 67% of those treated with enema. The 90% confidence interval for the difference in remission rates was 0 to 24 and thus within the clinically acceptable range of therapeutic equivalence. At the end of the 2nd phase, 70% of patients switched to foam were in remission vs 65% to the enema. Two patients discontinued treatment with foam prematurely due to anal burning. No clinically important changes were seen in the laboratory tests.Salofalk foam and enema are equally effective for the treatment of proctitis, proctosigmoiditis and left-sided ulcerative colitis. The new foam preparation is as well tolerated and accepted as enemas and can be used as a therapeutic alternative to conventional mesalazine enema formulations.

Published
2000

17. The first two years of colorectal cancer screening in Ferrara, Italy

Author

Matarese, V. G., Feo, Carlo, Lanza, Giovanni, Fusetti, Nadia, Carpanelli, M. C., Cataldo, S., Cifalà, V., Ferretti, Stefano, Gafa', Roberta, Marzola, M., Montanari, E., Palmonari, C, Simone, Loredana, Trevisani, L, Stockbrugger, R., and Gullini, S.

Subjects
Adenoma, Colorectal neoplasms, Mass screening, Therapy, Adjuvant chemotherapy, Follow-up studies, NO
Published
2011

19. Diagnosis, treatment and survival of patients with hepatorenal syndrome: A survey on daily medical practice

Author

Salerno, F., Cazzaniga, M., Merli, M., Spinzi, G., Saibeni, S., Salmi, A., Fagiuoli, S., Spadaccini, A., Trotta, E., Laffi, G., Koch, M., Riggio, O., Boccia, S., Felder, M., Balzani, S., Bruno, S., Angeli, P., Gobbo, G., Monti, V., Ridola, L., Terreni, N., Facciotto, C., Olivari, N., Gaffuri, G., Russo, L., Gatta, A., Romanelli, R. G., Marra, F., Moretti, A., Mangone, M., Gullini, S., Chilovi, F., Casetti, T., Okolicsanyi, L., Alimonti, P., Pazzi, P., Salvagnini, M., Colli, A., Andreoletti, M., Leo, P., Bellis, L., Lorenzini, I., Salerno, F, Cazzaniga, M, Merli, M, Spinzi, G, Saibeni, S, Salmi, A, Fagiuoli, S, Spadaccini, A, Trotta, E, Laffi, G, Koch, M, Riggio, O, Boccia, S, Felder, M, Balzani, S, Bruno, S, and Angeli, P

Subjects
Male, medicine.medical_specialty, kidney, ascites, hepatorenal syndrome, liver cirrhosis, midodrine, portal hypertension, terlipressin, Midodrine, Cohort Studies, Spontaneous bacterial peritonitis, Hepatorenal syndrome, Albumins, Internal medicine, Ascites, Prevalence, medicine, Humans, Vasoconstrictor Agents, Prospective Studies, Prospective cohort study, Aged, Hepatology, business.industry, Mortality rate, Middle Aged, medicine.disease, Surgery, Treatment Outcome, Italy, Ascite, Female, Liver function, medicine.symptom, business, Terlipressin, medicine.drug
Abstract

Background & Aims: Hepatorenal syndrome (HRS) is a severe complication of cirrhosis with ascites. The International Ascites Club recommended strict diagnostic criteria and treatment with vasoconstrictors and albumin. Aim of this prospective cohort study was to investigate the prevalence of HRS, diagnostic criteria, treatment and 3-month outcome in the daily-clinical-practice. Methods: Two-hundred-fifty-three patients with cirrhosis and renal failure consecutively admitted to 21 Italian hospitals were recruited. Results: The prevalence of HRS was 45.8% (30% type-1 and 15.8% type-2). In 36% of cases HRS was presumed because not all diagnostic criteria could be fulfilled. In 8% of cases HRS was superimposed on an organic nephropathy. Patients with HRS type-1 were younger and showed higher leukocyte count, higher respiratory rates, and worse liver function scores. Sixty-four patients with HRS type-1 received vasoconstrictors (40 terlipressin and 24 midodrine/octreotide). A complete response was obtained in 19 cases (30%) and a partial response in 13 (20%). Age was the only independent predictor of response (p = 0.033). Three-month survival of patients with HRS type-1 was 19.7%. Survival was better in patients who responded to therapy. Age (p = 0.017), bilirubin (p = 0.012), and creatinine increase after diagnostic volume expansion (p = 0.02) independently predicted death. The mortality rate was 97% among patients with at least two negative predictors. Conclusions: The diagnostic criteria of HRS in our daily-clinical-practice could not be completely fulfilled in one third of cases. The treatment with vasoconstrictors and albumin was widely implemented. Mortality was strongly predicted by simple baseline variables.

Published
2011

20. Guidelines for the management of Helicobacter pylori infection in Italy: The III Working Group Consensus Report 2015

Author

Zagari, R. M., Romano, M., Ojetti, Veronica, Stockbrugger, R., Gullini, S., Annibale, B., Farinati, F., Ierardi, E., Maconi, G., Rugge, M., Calabrese, C., Di Mario, F., Luzza, F., Pretolani, S., Savio, A., Gasbarrini, Giovanni Battista, Caselli, M., Ojetti V. (ORCID:0000-0002-8953-0707), Gasbarrini G., Zagari, R. M., Romano, M., Ojetti, Veronica, Stockbrugger, R., Gullini, S., Annibale, B., Farinati, F., Ierardi, E., Maconi, G., Rugge, M., Calabrese, C., Di Mario, F., Luzza, F., Pretolani, S., Savio, A., Gasbarrini, Giovanni Battista, Caselli, M., Ojetti V. (ORCID:0000-0002-8953-0707), and Gasbarrini G.

Abstract

Knowledge on the role of Helicobacter pylori (HP) infection is continually evolving, and treatment is becoming more challenging due to increasing bacterial resistance. Since the management of HP infection is changing, an update of the national Italian guidelines delivered in 2007 was needed. In the III Working Group Consensus Report 2015, a panel of 17 experts from several Italian regions reviewed current evidence on different topics relating to HP infection. Four working groups examined the following topics: (1) "open questions" on HP diagnosis and treatment (focusing on dyspepsia, gastro-oesophageal reflux disease, non-steroidal anti-inflammatory drugs or aspirin use and extra-gastric diseases); (2) non-invasive and invasive diagnostic tests; (3) treatment of HP infection; (4) role of HP in the prevention of gastric cancer. Statements and recommendations were discussed and a consensus reached in a final plenary session held in February 2015 in Bologna. Recommendations are based on the best current evidence to help physicians manage HP infection in Italy. The guidelines have been endorsed by the Italian Society of Gastroenterology and the Italian Society of Digestive Endoscopy.

Published
2015

21. Hepabiliary alterations in patients with inflammatory bowel disease: A multicenter study

Author

RIEGLER, Gabriele, DíIncà R, Sturniolo GC, Corrao G, Del Vecchio Blanco C, Di Leo V, Carratù R, Ingrosso M, Pelli MA, Morini S, Valpiani D, Cantarini D, Usai P, Papi C, Caprilli R, Gruppo Italiano per lo Studio del Colon e. del Retto: Russo MI, Marano M, Esposito P, Francavilla A, Morelli A, Lorenzetti R, Miglio F, Taranto D, Beneduce F, Gullini S, Cherchi MV, Capurso L, Rosoni R., VIETRI, Maria Teresa, Riegler, Gabriele, Díincà, R, Sturniolo, Gc, Corrao, G, Del Vecchio Blanco, C, Di Leo, V, Carratù, R, Ingrosso, M, Pelli, Ma, Morini, S, Valpiani, D, Cantarini, D, Usai, P, Papi, C, Caprilli, R, Gruppo Italiano per lo Studio del Colon e., del Retto: Russo MI, Marano, M, Vietri, Maria Teresa, Esposito, P, Francavilla, A, Morelli, A, Lorenzetti, R, Miglio, F, Taranto, D, Beneduce, F, Gullini, S, Cherchi, Mv, Capurso, L, and Rosoni, R.

Published
1998

24. Colonoscopy practice in Italy: a prospective survey on behalf of the Italian Association of Hospital Gastroenterologists

Author

Radaelli, F, Meucci, G, Minoli, G, Italian Association of Hospital Gastroenterologists Alluminio, P, Amuso, M, Angelini, G, Anti, M, Baldi, F, Balzana, M, Barberani, F, Bargiggia, S, Barresi, G, Bedosti, M, Belmonte, A, Benedetti, A, Benedetti, E, Benini, M, Beretta, L, Beretta, P, Fontana, A, Mauro, B, Bianco, R, Bierti, L, Bigazzi, U, Boccia, S, Bonello, F, Boscarino, S, Bottini, E, Bresci, G, Briglia, U, Brunelli, E, Buggiani, D, Calandra, A, Candidi, A, Caneschi, F, Cannizzaro, R, Cappuccino, V, Caputi, O, Cardelli, A, Caronia, V, Cattuto, C, Cestari, E, Chilovi, F, Cifatte, D, Ciliberto, E, Cimino, F, Cipolletta, V, Cirillo, M, Cocozza, U, Colantuoni, E, Coli, A, Colombo, E, Comin, U, Conti, W, Cortini, C, Criscione, S, Crotta, S, Cutela, P, D'Imperio, N, Dalia, G, Dall'Oglio, L, Dal Pane, M, Dante, P, Dato, D, Dattola, L, De Bernardin, M, De Boni, M, De Conca, V, Dell'Amico, I, Dell'Anna, A, Della Spoletina, A, Delogu, G, Del Piano, M, Di Cicco, M, Di Filippo, G, Di Giorgio, P, Di Mitri, R, Di Piero, A, Di Piramo, D, Di Todaro, E, Dicillo, M, Dodero, C, Doldo, P, Drago, D, Dubla, G, Dughera, L, Dusio, P, Ederle, A, Evola, M, Fachinetti, F, Faraldo, G, Farroni, F, Fasoli, R, Ferrara, A, Ferrari, A, Ferrari, C, Ferraris, L, Ferraris, R, Ferrini, G, Ferrini, L, Foco, A, Forte, G, Francavilla, A, Franzè, A, Fregoni, D, Frieri, Giuseppe, Gaia, E, Galasso, F, Galgani, P, Gamberucci, G, Gatti, L, Gatti, M, Gemme, C, Ghione, S, Ghisotti, E, Giaccari, S, Giannelli, C, Giorcelli, V, Giuri, G, Giurissa, A, Grassini, M, Grasso, G, Graziani, Mg, Gualtiero, J, Gullini, S, Gullotta, R, Iaquinto, G, Jacoponi, S, Laganà, S, Lamanda, R, Lattanzio, R, Lauri, A, Lecis, Pe, Ledda, P, Leone, S, Ligas, E, Liuzzi, N, Lochis, D, Longaroni, M, Lorenzini, I, Loriga, P, Lussu, B, Luzza, F, Madia, D, Malfitana, G, Mallozzi, Ef, Mancini, S, Mangiarotti, R, Manildo, M, Manneschi, L, Marcon, V, Marino, M, Marrucci, A, Martines, H, Maruelli, A, Massari, M, Massidda, C, Mauri, R, Mazzarello, Pl, Mazzolla, E, Mellone, C, Meloni, M, Merighi, A, Mescia, P, Michetti, P, Milan, L, Milandri, G, Miori, G, Monastra, S, Moncelli, G, Monica, F, Montanaro, F, Moretti, M, Morini, S, Mosca, F, Mosca, D, Moschetta, R, Mura, G, Naim, G, Nardella, G, Natale, A, Negrini, F, Niccoli, G, Nova, A, Occhipinti, P, Ocera, S, Orlandi, Pg, Orsini, O, Pagani, E, Paliani, O, Pardocchi, D, Parodi, Cm, Pasini, D, Pasquale, L, Pasquali, L, Paterlini, A, Pellecchia, A, Pera, A, Perego, M, Perugini, B, Petracca, F, Peyre, S, Piccoli, F, Pilati, S, Pierucci, E, Pizzetti, P, Pizzolato, S, Polimeni, F, Politano, S, Polo, S, Portaluri, F, Prada, A, Privitera, U, Quaranta, S, Raguzzi, I, Ravelli, P, Recchia, S, Revetria, P, Ripoli, D, Rocca, F, Roda, E, Rogheto, M, Rosati, S, Rosina, F, Rossi, A, Rotolo, A, Sabadini, Gr, Saffiotti, O, Salerno, D, Sanesi, A, Sanna, S, Saracco, G, Savarino, V, Scaccianoce, G, Scarpulla, G, Schiffino, L, Schippa, P, Sebastiani, P, Servillo, F, Sgarbi, D, Sigillito, D, Snider, L, Sorrentini, I, Spadaccini, A, Sticchi, V, Sturniolo, Gc, Suriani, R, Tammaro, L, Tarchi, F, Tasini, E, Tebaldi, M, Terruzzi, V, Testoni, Pa, Tonelli, F, Trapè, R, Triossi, O, Usai, P, Usula, E, Vecchi, M, Vecchi, E, Ventrucci, M, Viero, K, Virgilio, C, Viviani, G, Zampaletta, U, and Zilli, M.

Subjects
Colonoscopy, Endoscopy
Published
2008

40. MULTICENTER PRELIMINARY EXPERIENCE WITH “MIROCAM” CAPSULE ENDOSCOPY

Author

Pezzoli, A., primary, Fusetti, N., additional, Grasso, T., additional, Cantoni, F., additional, Di Bella, S., additional, Cantù, P., additional, Brancaccio, M.L., additional, Zancanella, L., additional, Chilovi, F., additional, Casetti, T., additional, Iaquinto, G., additional, Brunati, S., additional, Grazia, M., additional, and Gullini, S., additional

Published
2009
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41. MULTICENTER STUDY OF INTEROBSERVER AGREEMENT IN DESCRIBING CAPSULE ENDOSCOPY FINDINGS

Author

Pezzoli, A., primary, Cannizzaro, R., additional, Pennazio, M., additional, Rondonotti, E., additional, Bidoli, E., additional, Zancanella, L., additional, Cantoni, F., additional, Brancaccio, M.L., additional, Caravelli, G., additional, Melina, R., additional, Casetti, T., additional, Iaquinto, G., additional, Chilovi, F., additional, and Gullini, S., additional

Published
2009
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49. OC1.06.3 PROSPECTIVE, RANDOMIZED, DOUBLE-BLINDED, MULTICENTER STUDY COMPARING PEG VS NAP FOR CAPSULE ENDOSCOPY BOWEL PREPARATION

Author

Pezzoli, A., primary, Cannizzaro, R., additional, Fusetti, N., additional, Bidoli, E., additional, Cantoni, F., additional, Casetti, T., additional, Zancanella, L., additional, Chilovi, F., additional, Melina, R., additional, Iaquinto, G., additional, Caravelli, G., additional, Monastra, S., additional, and Gullini, S., additional

Published
2008
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