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The article discusses the development of antibacterial fibrous patches made from alginate and Ceylon cinnamon using nozzle-pressurized spinning technology. Topics include the production of alginate fibers through a novel spinning process, the incorporation of Ceylon cinnamon to enhance antibacterial activity, and the assessment of the cytotoxicity and antibacterial effectiveness of the resulting fibrous patches.

Centrifugal spinning is a technology used to generate small diameter fibers and has been extensively studied for its vast applications in biomedical engineering. Centrifugal spinning is known for its rapid production rate and has inspired the creation of other technologies which leverage the high‐speed rotation, namely Pressurized Gyration. Pressurized gyration incorporates a unique applied gas pressure which serves to provide additional control over the fiber production process. The resulting fibers are uniquely suitable for a range of healthcare‐related applications that are thoroughly discussed in this work, which involve scaffolds for tissue engineering, solid dispersions for drug delivery, antimicrobial meshes for filtration and bandage‐like fibrous coverings for wound healing. In this review, the notable recent developments in centrifugal spinning and pressurized gyration are presented and how these technologies are being used to further the range of uses of biomaterials engineering, for example the development of core‐sheath fabrication techniques for multi‐layered fibers and the combination with electrospinning to produce advanced fiber mats. The enormous potential of these technologies and their future advancements highlights how important they are in the biomedical discipline. This article is categorized under:Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and ReplacementNanotechnology Approaches to Biology > Nanoscale Systems in BiologyBiology‐Inspired Nanomaterials > Lipid‐Based Structures [ABSTRACT FROM AUTHOR]

Binary polymer systems provide significant advantages in the preparation of materials used in biomedical applications. To highlight the importance and need of binary polymer systems in biomedical applications; utilisations of nano-carrier and fibre are discussed in detail in terms of their use as biomaterial, and their potential for further development with focus on dual and sequential drug delivery applications. On the other hand, in fibre technology, creation of binary polymer systems have been investigated using spinning processes such as electrospinning and even more recently innovated pressurised gyration. How these methods can be used to promote the mass production of binary polymer systems with various morphologies and characteristics are elucidated. The effects of different polymer materials, including solvents, mechanical properties, and the rate of degradation of polymers, are discussed. Current polymer blending systems and manufacturing processes are analysed, and technologies for biomaterials are carefully considered with up to date details. [ABSTRACT FROM AUTHOR]

Acne vulgaris is one of the most common chronic diseases worldwide with the high prevalence ratio of about 80–85% in patients who are in puberty period. For the treatment options, many conventional dosage forms are available; however, existing limitations of systemic administration of drugs (oral antibiotics), such as adverse events and resistance, led for seek of new formulation options. In this study, liposomes containing tetracycline HCl and tretinoin were prepared by the film formation method. In vitro characterization studies revealed that liposomes (111.10 ± 8.02 nm; P.D.I.=0.198 ± 0.03; Z.P.=25.83 ± 0.40 mV) with an encapsulation efficiency more than 80% for both APIs were formulated. In order to maintain a suitable viscosity for topical application, optimized liposomal formulations were dispersed in carbopol-based gel. In vitro release of APIs was sustained for 24 hours with released amounts of 56.44% and 58.44% for tetracycline HCl and tretinoin, respectively. Stability evaluation of both liposomes and liposomes in hydrogels was investigated for 6 months at 4 °C and 25 °C; and no statistically significant change was observed in terms of particle size, zeta potential, encapsulation efficiency, appearance, pH, and viscosity. Cytotoxicity tests confirmed the nontoxic structure of liposomal gel formulations on mice fibroblast cells. In addition, antibacterial efficacy has been proven with Staphylococcus aureus and Streptococcus epidermidis strains as well as the effect on biofilm formation and eradication. As a result, we hereby presented a new combination drug product, which consists of dual active ingredients having comedolytic and bacteriostatic effects in a single, safe, and stable liposome formulation. [ABSTRACT FROM AUTHOR]

ABSTRACT Polyurethanes (PUs) are the most widely used polymers because of their biocompatibility, tunable mechanical properties, and chemical versatility. In this study, a two-step condensation polymerization of polycaprolactone diol and hexamethylene diisocyanate was carried out, and a glutamic acid ester derivative, (2 S)-bis(2-hydroxypropyl) 2-aminopentane dioate (HPAP), was used as a new chain extender to accelerate the biodegradation properties of PU. HPAP was synthesized by the Fischer esterification of l-glutamic acid. The chemical structure of HPAP was confirmed by high-resolution mass spectroscopy and m/z (EI) was found to be 264.1447 [calculated value = 264.1443 for C11H21NO6 (M+)]. The Berry plot of static light-scattering measurements showed that PU-HPAP had a weight-average molecular weight and radius of gyration of 33,100 g/mol and 1420 nm, respectively. The presence of HPAP in the PU structure facilitated hydrogen bonding between the polymer chains and increased the glass-transition temperature from −56 °C (PU) to −50 °C (PU-HPAP). PU-HPAP showed the highest hydrophilicity and surface free energy among all of samples, and this accelerated the in vitro biodegradation period via surface erosion. In addition, PU-HPAP did not show any cytotoxic effects on the L929 cells. A new biodegradable and biocompatible PU-HPAP was obtained as candidate for tissue engineering applications. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45764. [ABSTRACT FROM AUTHOR]

Centrifugal spinning is a technology used to generate small diameter fibers and has been extensively studied for its vast applications in biomedical engineering. Centrifugal spinning is known for its rapid production rate and has inspired the creation of other technologies which leverage the high-speed rotation, namely Pressurized Gyration. Pressurized gyration incorporates a unique applied gas pressure which serves to provide additional control over the fiber production process. The resulting fibers are uniquely suitable for a range of healthcare-related applications that are thoroughly discussed in this work, which involve scaffolds for tissue engineering, solid dispersions for drug delivery, antimicrobial meshes for filtration and bandage-like fibrous coverings for wound healing. In this review, the notable recent developments in centrifugal spinning and pressurized gyration are presented and how these technologies are being used to further the range of uses of biomaterials engineering, for example the development of core-sheath fabrication techniques for multi-layered fibers and the combination with electrospinning to produce advanced fiber mats. The enormous potential of these technologies and their future advancements highlights how important they are in the biomedical discipline. This article is categorized under: Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology-Inspired Nanomaterials > Lipid-Based Structures., (© 2023 The Authors. WIREs Nanomedicine and Nanobiotechnology published by Wiley Periodicals LLC.)