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Competing Interests: Competing interests: RL, BC and HYO are supported by grants from the National Youth Council (NYC) of Singapore and the Medical Grand Challenge (MGC) of the National University of Singapore (NUS). DVG reports investment in DoctorBell (acquired by MaNaDr, Mobile Health), VISRE, AskDr and Shyfts. He declares receipt of travel funding from the Mobile Health Education grant, Commonwealth Fellowship in Innovation award and National Youth Fund award, for clinical research training and collaborations at Oxford University and Stanford University. He reports serving as senior lecturer and faculty advisor to the medical innovation program of NUS.