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232 results on '"Gundle, Kenneth R."'

1. Survival and failure modes of the Compress® spindle and expandable distal femur endoprosthesis among pediatric patients: A multi‐institutional study

Author

Tanaka, Kara S, Andaya, Veronica R, Thorpe, Steven W, Gundle, Kenneth R, Hayden, James B, Duong, Yee‐Cheen, Avedian, Raffi S, Mohler, David G, Morse, Lee J, Zimel, Melissa N, O'Donnell, Richard J, Fang, Andrew, Randall, Robert Lor, Tran, Tina H, New, Christin, Wustrack, Rosanna L, and FORCE, other members of Study Group

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Rehabilitation, Pediatric, Child, Humans, Femoral Neoplasms, Prosthesis Design, Retrospective Studies, Prosthesis Implantation, Prosthesis Failure, Osteotomy, Treatment Outcome, Risk Factors, Femur, Reoperation, Bone Neoplasms, expandable endoprosthesis, limb-salvage surgery, pediatric sarcoma, other members of Study Group FORCE, Oncology and Carcinogenesis, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundExpandable endoprostheses can be used to equalize limb length for pediatric patients requiring reconstruction following large bony oncologic resections. Outcomes of the Compress® Compliant Pre-Stress (CPS) spindle paired with an Orthopedic Salvage System expandable distal femur endoprosthesis have not been reported.MethodsWe conducted a multi-institutional retrospective study of pediatric patients with distal femoral bone sarcomas reconstructed with the above endoprostheses. Statistical analysis utilized Kaplan-Meier survival technique and competing risk analysis.ResultsThirty-six patients were included from five institutions. Spindle survivorship was 86.3% (95% confidence interval [CI], 67.7-93.5) at 10 years. Two patients had a failure of osseointegration (5.7%), both within 12 months. Twenty-two (59%) patients had 70 lengthening procedures, with mean expansions of 3.2 cm (range: 1-9) over 3.4 surgeries. The expandable mechanism failed in eight patients with a cumulative incidence of 16.1% (95% CI, 5.6-31.5) at 5 years. Twenty-nine patients sustained International Society of Limb Salvage failures requiring 63 unplanned surgeries. Periprosthetic joint infection occurred in six patients (16.7%). Limb preservation rate was 91% at 10 years.ConclusionsThere is a high rate of osseointegration of the Compress® spindle among pediatric patients when coupled with an expandable implant. However, there is a high rate of expansion mechanism failure and prosthetic joint infections requiring revision surgery.Level of evidenceLevel IV, therapeutic study.

Published
2023

7. Early, precise, and safe clinical evaluation of the pharmacodynamic effects of novel agents in the intact human tumor microenvironment

Author

Gundle, Kenneth R., primary, Rajasekaran, Karthik, additional, Houlton, Jeffrey, additional, Deutsch, Gary B., additional, Ow, Thomas J., additional, Maki, Robert G., additional, Pang, John, additional, Nathan, Cherie-Ann O., additional, Clayburgh, Daniel, additional, Newman, Jason G., additional, Brinkmann, Elyse, additional, Wagner, Michael J., additional, Pollack, Seth M., additional, Thompson, Matthew J., additional, Li, Ryan J., additional, Mehta, Vikas, additional, Schiff, Bradley A., additional, Wenig, Barry I., additional, Swiecicki, Paul L., additional, Tang, Alice L., additional, Davis, Jessica L., additional, van Zante, Annemieke, additional, Bertout, Jessica A., additional, Jenkins, Wendy, additional, Turner, Atticus, additional, Grenley, Marc, additional, Burns, Connor, additional, Frazier, Jason P., additional, Merrell, Angela, additional, Sottero, Kimberly H. W., additional, Derry, Jonathan M. J., additional, Gillespie, Kate C., additional, Mills, Bre, additional, and Klinghoffer, Richard A., additional

Published
2024
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24. Supplemental Figure 3 from Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma

Author

Gundle, Kenneth R., primary, Deutsch, Gary B., primary, Goodman, Howard J., primary, Pollack, Seth M., primary, Thompson, Matthew J., primary, Davis, Jessica L., primary, Lee, Mee-Young, primary, Ramirez, Daniel C., primary, Kerwin, William, primary, Bertout, Jessica A., primary, Grenley, Marc O., primary, Sottero, Kimberly H.W., primary, Beirne, Emily, primary, Frazier, Jason, primary, Dey, Joyoti, primary, Ellison, Micah, primary, Klinghoffer, Richard A., primary, and Maki, Robert G., primary

Published
2023
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25. Supplemental Figure 5 from Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma

Author

Gundle, Kenneth R., primary, Deutsch, Gary B., primary, Goodman, Howard J., primary, Pollack, Seth M., primary, Thompson, Matthew J., primary, Davis, Jessica L., primary, Lee, Mee-Young, primary, Ramirez, Daniel C., primary, Kerwin, William, primary, Bertout, Jessica A., primary, Grenley, Marc O., primary, Sottero, Kimberly H.W., primary, Beirne, Emily, primary, Frazier, Jason, primary, Dey, Joyoti, primary, Ellison, Micah, primary, Klinghoffer, Richard A., primary, and Maki, Robert G., primary

Published
2023
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26. Supplemental Figure 4 from Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma

Author

Gundle, Kenneth R., primary, Deutsch, Gary B., primary, Goodman, Howard J., primary, Pollack, Seth M., primary, Thompson, Matthew J., primary, Davis, Jessica L., primary, Lee, Mee-Young, primary, Ramirez, Daniel C., primary, Kerwin, William, primary, Bertout, Jessica A., primary, Grenley, Marc O., primary, Sottero, Kimberly H.W., primary, Beirne, Emily, primary, Frazier, Jason, primary, Dey, Joyoti, primary, Ellison, Micah, primary, Klinghoffer, Richard A., primary, and Maki, Robert G., primary

Published
2023
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27. Supplemental Table 3 from Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma

Author

Gundle, Kenneth R., primary, Deutsch, Gary B., primary, Goodman, Howard J., primary, Pollack, Seth M., primary, Thompson, Matthew J., primary, Davis, Jessica L., primary, Lee, Mee-Young, primary, Ramirez, Daniel C., primary, Kerwin, William, primary, Bertout, Jessica A., primary, Grenley, Marc O., primary, Sottero, Kimberly H.W., primary, Beirne, Emily, primary, Frazier, Jason, primary, Dey, Joyoti, primary, Ellison, Micah, primary, Klinghoffer, Richard A., primary, and Maki, Robert G., primary

Published
2023
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28. Supplemental Table 2 from Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma

Author

Gundle, Kenneth R., primary, Deutsch, Gary B., primary, Goodman, Howard J., primary, Pollack, Seth M., primary, Thompson, Matthew J., primary, Davis, Jessica L., primary, Lee, Mee-Young, primary, Ramirez, Daniel C., primary, Kerwin, William, primary, Bertout, Jessica A., primary, Grenley, Marc O., primary, Sottero, Kimberly H.W., primary, Beirne, Emily, primary, Frazier, Jason, primary, Dey, Joyoti, primary, Ellison, Micah, primary, Klinghoffer, Richard A., primary, and Maki, Robert G., primary

Published
2023
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29. Supplemental Figure 2 from Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma

Author

Gundle, Kenneth R., primary, Deutsch, Gary B., primary, Goodman, Howard J., primary, Pollack, Seth M., primary, Thompson, Matthew J., primary, Davis, Jessica L., primary, Lee, Mee-Young, primary, Ramirez, Daniel C., primary, Kerwin, William, primary, Bertout, Jessica A., primary, Grenley, Marc O., primary, Sottero, Kimberly H.W., primary, Beirne, Emily, primary, Frazier, Jason, primary, Dey, Joyoti, primary, Ellison, Micah, primary, Klinghoffer, Richard A., primary, and Maki, Robert G., primary

Published
2023
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30. Supplemental Figure 1 from Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma

Author

Gundle, Kenneth R., primary, Deutsch, Gary B., primary, Goodman, Howard J., primary, Pollack, Seth M., primary, Thompson, Matthew J., primary, Davis, Jessica L., primary, Lee, Mee-Young, primary, Ramirez, Daniel C., primary, Kerwin, William, primary, Bertout, Jessica A., primary, Grenley, Marc O., primary, Sottero, Kimberly H.W., primary, Beirne, Emily, primary, Frazier, Jason, primary, Dey, Joyoti, primary, Ellison, Micah, primary, Klinghoffer, Richard A., primary, and Maki, Robert G., primary

Published
2023
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31. Supplemental Table 1 from Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma

Author

Gundle, Kenneth R., primary, Deutsch, Gary B., primary, Goodman, Howard J., primary, Pollack, Seth M., primary, Thompson, Matthew J., primary, Davis, Jessica L., primary, Lee, Mee-Young, primary, Ramirez, Daniel C., primary, Kerwin, William, primary, Bertout, Jessica A., primary, Grenley, Marc O., primary, Sottero, Kimberly H.W., primary, Beirne, Emily, primary, Frazier, Jason, primary, Dey, Joyoti, primary, Ellison, Micah, primary, Klinghoffer, Richard A., primary, and Maki, Robert G., primary

Published
2023
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32. Supplementary Legend from Multiplexed Evaluation of Microdosed Antineoplastic Agents In Situ in the Tumor Microenvironment of Patients with Soft Tissue Sarcoma

Author

Gundle, Kenneth R., primary, Deutsch, Gary B., primary, Goodman, Howard J., primary, Pollack, Seth M., primary, Thompson, Matthew J., primary, Davis, Jessica L., primary, Lee, Mee-Young, primary, Ramirez, Daniel C., primary, Kerwin, William, primary, Bertout, Jessica A., primary, Grenley, Marc O., primary, Sottero, Kimberly H.W., primary, Beirne, Emily, primary, Frazier, Jason, primary, Dey, Joyoti, primary, Ellison, Micah, primary, Klinghoffer, Richard A., primary, and Maki, Robert G., primary

Published
2023
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33. "It Is A Carrot-Stick Model": A Qualitative Study of Rural-Serving Clinician and Rural-Residing Veteran Perceptions of Requirements to Quit Smoking prior to Elective Surgery.

Author

Golden, Sara E., Young, Allison, Sun, Christina J., Mayeda, Marissa Song, Katz, David A., Vander Weg, Mark W., Gundle, Kenneth R., and Bailey, Steffani R.

Subjects
PREVENTION of surgical complications, ELECTIVE surgery, SMOKING cessation, RURAL conditions, ORTHOPEDIC surgery, PREOPERATIVE period, ATTITUDES of medical personnel, RESEARCH methodology, PHYSICIANS' attitudes, PHARMACISTS' attitudes, INTERVIEWING, MEDICAL personnel, PSYCHOLOGY of veterans, PATIENTS' attitudes, QUALITATIVE research, EXPERIENCE, HEALTH attitudes, RESEARCH funding, DESCRIPTIVE statistics, RURAL health, STATISTICAL sampling, ELECTRONIC health records, PATIENT education, THEMATIC analysis, MEDICAL care of veterans
Abstract

Introduction. Some medical centers and surgeons require patients to stop smoking cigarettes prior to elective orthopaedic surgeries in an effort to decrease surgical complications. Given higher rates of smoking among rural individuals, rural patients may be disproportionately impacted by these requirements. We assessed the perceptions and experiences of rural-residing Veterans and clinicians related to this requirement. Methods. We conducted qualitative semistructured one-on-one interviews of 26 rural-residing veterans, 10 VA orthopaedic surgery staff (from two Veterans Integrated Services Networks), 24 PCPs who serve rural veterans (14 VA; 10 non-VA), and 4 VA pharmacists. Using the knowledge, attitudes, and behavior framework, we performed conventional content analysis. Results. We found three primary themes across respondents: (1) knowledge of and the evidence base for the requirement varied widely; (2) strong personal attitudes toward the requirement; and (3) implementation and possible implications of this requirement. All surgery staff reported knowledge of requirements at their institution. VA PCPs reported knowledge of requirements but typically could not recall specifics. Most patients were unaware. The majority of respondents felt this requirement could increase motivation to quit smoking. Some PCPs felt a more thorough explanation of smoking-related complications would result in increased quit attempts. About half of all patients reported belief that the requirement was reasonable regardless of initial awareness. Respondents expressed little concern that the requirement might increase rural-urban disparities. Most PCPs and patients felt that there should be exceptions for allowing surgery, while surgical staff disagreed. Discussion. Most respondents thought elective surgery was a good motivator to quit smoking; but patients, PCPs, and surgical staff differed on whether there should be exceptions to the requirement that patients quit preoperatively. Future efforts to augment perioperative smoking cessation may benefit from improving coordination across services and educating patients more about the benefits of quitting. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Abstract CT216: A phase 0 master protocol utilizing a novel intratumoral microdosing approach for simultaneously evaluating multiple drugs and drug combinations in patients with solid tumors

Author

Rajasekaran, Karthik, primary, Newman, Jason G., additional, Maki, Robert G., additional, Ow, Thomas J., additional, Mehta, Vikas, additional, Gundle, Kenneth R., additional, Clayburgh, Daniel R., additional, Li, Ryan J., additional, Porosnicu, Mercedes, additional, Nathan, Cherie-Ann O., additional, Tang, Alice, additional, Hatton, Beryl A., additional, Sottero, Kimberly H., additional, Kung, Gloria, additional, Grenley, Marc O., additional, Anderson, Kirsten, additional, and Klinghoffer, Richard A., additional

Published
2022
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42. CORR Insights®: What Are the Trends in Research Publication Misrepresentation Among Orthopaedic Residency and Fellowship Applicants From 1996 to 2019? A Systematic Review.

Author

Gundle, Kenneth R.

Subjects
*RESIDENTS (Medicine), *MEDICAL students
Abstract

Research misconduct among applicants is at least partially a symptom of the deficiencies of our current orthopaedic surgery residency application process. The preference signaling instituted for this cycle of the orthopaedic surgery match is very promising, though data on the impact of preference signaling are limited [[1]]. CORR Insights®: What Are the Trends in Research Publication Misrepresentation Among Orthopaedic Residency and Fellowship Applicants From 1996 to 2019? Orthopaedic surgery residency program adherence to universal interview offer day guidelines: a retrospective analysis. [Extracted from the article]

Published
2023
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