196 results on '"Gunsenheimer-Bartmeyer, Barbara"'
Search Results
2. SARS-CoV-2 seroprevalence among people living with HIV in the German HIV-1 Seroconverter Cohort, 2020–2022
- Author
-
Hohn, Oliver, Meixenberger, Karolin, Volkwein, Alexander, Körner, Kyra, Icli, Suheda, Koppe, Uwe, Hower, Martin, Bremer, Viviane, Gunsenheimer-Bartmeyer, Barbara, and Bannert, Norbert
- Published
- 2024
- Full Text
- View/download PDF
3. Wo steht Deutschland im Kampf gegen HIV?
- Author
-
Gunsenheimer-Bartmeyer, Barbara
- Published
- 2024
- Full Text
- View/download PDF
4. AIDS-defining events among people living with HIV who have been under continuous antiretroviral therapy for more than one year, a German cohort study 1999–2018
- Author
-
Pantke, Annemarie, Kollan, Christian, Gunsenheimer-Bartmeyer, Barbara, Jensen, Björn-Erik Ole, Stephan, Christoph, Degen, Olaf, Schürmann, Dirk, Kurth, Tobias, Bremer, Viviane, and Koppe, Uwe
- Published
- 2024
- Full Text
- View/download PDF
5. Prevalence of HIV in people with potential HIV-indicator conditions in Germany: an analysis of data from statutory health insurances
- Author
-
Valbert, Frederik, Behrens, Georg M.N., Bickel, Markus, Boesecke, Christoph, Esser, Stefan, Dröge, Patrik, Ruhnke, Thomas, Krings, Amrei, Schmidt, Daniel, Koppe, Uwe, Gunsenheimer-Bartmeyer, Barbara, Wienholt, Lea, Wasem, Jürgen, and Neumann, Anja
- Published
- 2024
- Full Text
- View/download PDF
6. Developing a next level integrated genomic surveillance: Advances in the molecular epidemiology of HIV in Germany
- Author
-
Hanke, Kirsten, Rykalina, Vera, Koppe, Uwe, Gunsenheimer-Bartmeyer, Barbara, Heuer, Dagmar, and Meixenberger, Karolin
- Published
- 2024
- Full Text
- View/download PDF
7. Transmitted drug resistance and subtype patterns of viruses from reported new HIV diagnoses in Germany, 2017–2020
- Author
-
Fiebig, Uwe, Altmann, Britta, Hauser, Andrea, Koppe, Uwe, Hanke, Kirsten, Gunsenheimer-Bartmeyer, Barbara, Bremer, Viviane, Baumgarten, Axel, and Bannert, Norbert
- Published
- 2023
- Full Text
- View/download PDF
8. Optimization of HIV testing services in Germany using HIV indicator diseases: study protocol of the HeLP study
- Author
-
Valbert, Frederik, Koppe, Uwe, Schmidt, Daniel, Krings, Amrei, Gunsenheimer-Bartmeyer, Barbara, Dröge, Patrik, Ruhnke, Thomas, Behrens, Georg, Bickel, Markus, Boesecke, Christoph, Esser, Stefan, Wasem, Jürgen, and Neumann, Anja
- Published
- 2023
- Full Text
- View/download PDF
9. The impact of regional socioeconomic deprivation on the timing of HIV diagnosis: a cross-sectional study in Germany
- Author
-
Pantke, Annemarie, Hoebel, Jens, an der Heiden, Matthias, Michalski, Niels, Gunsenheimer-Bartmeyer, Barbara, Hanke, Kirsten, Bannert, Norbert, Bremer, Viviane, and Koppe, Uwe
- Published
- 2022
- Full Text
- View/download PDF
10. Barriers and facilitators to HIV and viral hepatitis testing in healthcare settings in Kyrgyz Republic: Protocol for a mixed-methods study (Preprint)
- Author
-
Sperle, Ida, primary, Lunchenkov, Nikolay, additional, Nurmatov, Zuridin S., additional, A. Bekbolotov, Aybek, additional, Stepanovich-Falke, Anastassiya, additional, Brandl, Michael, additional, Kysil, Olena, additional, Bivol, Stela, additional, Bremer, Viviane, additional, Gunsenheimer-Bartmeyer, Barbara, additional, and Dudareva, Sandra, additional
- Published
- 2024
- Full Text
- View/download PDF
11. Needs for an Integration of Specific Data Sources and Items – First Insights of a National Survey Within the German Center for Infection Research
- Author
-
Jakob, Carolin E.M., primary, Stecher, Melanie, additional, Fuhrmann, Sandra, additional, Wingen-Heimann, Sebastian, additional, Heinen, Stephanie, additional, Anton, Gabriele, additional, Behnke, Michael, additional, Behrends, Uta, additional, Boeker, Martin, additional, Castell, Stefanie, additional, Demski, Hans, additional, Diefenbach, Maximilian, additional, Falgenhauer, Jane C., additional, Fritzenwanker, Moritz, additional, Gastmeier, Petra, additional, Gerhard, Markus, additional, Glöckner, Stephan, additional, Golubovic, Mira, additional, Gunsenheimer Bartmeyer, Barbara, additional, Ingenerf, Josef, additional, Kaiser, Rolf, additional, Körner, Marie-Luise, additional, Loag, Wibke, additional, Mchardy, Alice, additional, Molitor, Ernst, additional, Nübel, Ulrich, additional, Pritsch, Michael, additional, Ramharter, Michael, additional, Rieg, Sigbert R., additional, Rupp, Jan, additional, Schindler, Daniela, additional, Schwudke, Dominik, additional, Spinner, Christoph, additional, Stottmeier, Benjamin, additional, Vehreschild, Maria, additional, Willmann, Matthias, additional, and Vehreschild, Jörg J., additional
- Published
- 2021
- Full Text
- View/download PDF
12. Barriers to using HIV pre-exposure prophylaxis (PrEP) and sexual behaviour after stopping PrEP: a cross-sectional study in Germany
- Author
-
Koppe, Uwe, Marcus, Ulrich, Albrecht, Stefan, Jansen, Klaus, Jessen, Heiko, Gunsenheimer-Bartmeyer, Barbara, and Bremer, Viviane
- Published
- 2021
- Full Text
- View/download PDF
13. Trends in human immunodeficiency virus diagnoses among men who have sex with men in North America, Western Europe, and Australia, 2000–2014
- Author
-
Chapin-Bardales, Johanna, Schmidt, Axel J., Guy, Rebecca J., Kaldor, John M., McGregor, Skye, Sasse, André, Archibald, Chris, Rank, Claudia, Casabona Barbarà, Jordi, Folch, Cinta, Vives, Núria, Cowan, Susan A., Cazein, Françoise, Velter, Annie, an der Heiden, Matthias, Gunsenheimer-Bartmeyer, Barbara, Marcus, Ulrich, Op de Coul, Eline L.M., van Sighem, Ard, Aldir, Isabel, Cortes Martins, Helena, Berglund, Torsten, Velicko, Inga, Gebhardt, Martin, Delpech, Valerie, Hughes, Gwenda, Nardone, Anthony, Hall, H. Irene, Johnson, Anna S., and Sullivan, Patrick S.
- Published
- 2018
- Full Text
- View/download PDF
14. Factors associated with the informal use of HIV pre-exposure prophylaxis in Germany: a cross-sectional study
- Author
-
Koppe, Uwe, Marcus, Ulrich, Albrecht, Stefan, Jansen, Klaus, Jessen, Heiko, Gunsenheimer-Bartmeyer, Barbara, and Bremer, Viviane
- Subjects
Prophylaxis ,HIV infections -- Prevention ,Emtricitabine ,HIV -- Prevention ,Sexually transmitted disease prevention ,Health insurance ,Health - Abstract
Introduction: Until September 2019, pre-exposure prophylaxis (PrEP) with tenofovir disoproxil/emtricitabine for HIV prevention was not covered by health insurance plans in Germany, and was only available through private prescriptions with self-pay or through informal non-prescription sources. The objective of this study was to investigate the proportion of informal PrEP use among PrEP users and to identify factors of public health relevance that might be associated with informal PrEP use. Methods: We conducted a cross-sectional study recruiting PrEP users independent of their PrEP source. Clients from anonymous community testing checkpoints, users of three dating apps for men who have sex with men residing in Germany and users of a PrEP community website, were recruited to complete a short anonymous online survey. Participants were recruited between 24 July and 3 September 2018. The results were analysed using univariable and multivariable logistic regressions. Results: We recruited 2005 participants currently using PrEP. The median age was 38 years, and 80.3% of the participants identified themselves as male (missing: 19.1%). Overall, 71.6% obtained PrEP through medical services with a private prescription or a clinical trial, and 17.4% obtained PrEP through informal sources (missing: 11.0%). The most common informal sources were ordering online from another country (8.8%), travel abroad (3.6%), and friends (2.5%). Factors associated with informa PrEP use were on demand/intermittent dosing (adjusted OR: 3.5, 95% CI 2.5 to 5.0) and not receiving medical tests during PrEP use (adjusted OR: 3.2, 95% CI 2.0 to 5.2). In addition, informal PrEP users who did not take PrEP daily had a strongly increased risk of starting PrEP without prior medical tests (adjusted stratum-specific OR = 31.7, 95% CI 4.6 to 219.5). Conclusions: Informal PrEP use was associated with a higher risk of not getting tested before and during PrEP use, which could lead to HIV infections resistant to tenofovir and emtricitabine if people with undiagnosed HIV use PrEP. Health insurance plans that cover PrEP and the accompanying routine tests could ensure adequate medical supervision of PrEP users and reduce barriers to PrEP use. Our findings strongly support the implementation of PrEP programmes in countries with similar patterns of informal PrEP use. Keywords: PrEP; men who have sex with men; testing; informal PrEP; non-daily use; affordability, 1 | INTRODUCTION Pre-exposure prophylaxis (PrEP), with tenofovir disoproxil/emtricitabine, has been proven to be highly effective in preventing HIV infections in men who have sex with men (MSM) and other [...]
- Published
- 2019
- Full Text
- View/download PDF
15. Antiretroviral treatment indications and adherence to the German-Austrian treatment initiation guidelines in the German ClinSurv HIV Cohort between 1999 and 2016
- Author
-
Stecher, Melanie, Schommers, Philipp, Schmidt, Daniel, Kollan, Christian, Gunsenheimer-Bartmeyer, Barbara, Lehmann, Clara, Platten, Martin, Fätkenheuer, Gerd, Vehreschild, Jörg Janne, and ClinSurv Study Group
- Published
- 2019
- Full Text
- View/download PDF
16. The Human Immunodeficiency Virus Continuum of Care in European Union Countries in 2013: Data and Challenges
- Author
-
European HIV Continuum of Care Working Group, Gourlay, Annabelle, Noori, Teymur, Pharris, Anastasia, Axelsson, Maria, Costagliola, Dominique, Cowan, Susan, Croxford, Sara, Monforte, Antonella d'Arminio, del Amo, Julia, Delpech, Valerie, Díaz, Asunción, Girardi, Enrico, Gunsenheimer-Bartmeyer, Barbara, Hernando, Victoria, Jose, Sophie, Leierer, Gisela, Nikolopoulos, Georgios, Obel, Niels, de Coul, Eline Op, Paraskeva, Dimitra, Reiss, Peter, Sabin, Caroline, Sasse, André, Schmid, Daniela, Sonnerborg, Anders, Spina, Alexander, Suligoi, Barbara, Supervie, Virginie, Touloumi, Giota, Van Beckhoven, Dominique, van Sighem, Ard, Vourli, Georgia, Zangerle, Robert, and Porter, Kholoud
- Published
- 2017
17. Primary resistance of viruses in reported new cases of HIV, 2017–2020—findings of a nationwide molecular HIV surveillance program
- Author
-
Fiebig, Uwe, primary, Altmann, Britta, additional, Hauser, Andrea, additional, Koppe, Uwe, additional, Hanke, Kirsten, additional, Gunsenheimer-Bartmeyer, Barbara, additional, Bremer, Viviane, additional, Baumgarten, Axel, additional, and Bannert, Norbert, additional
- Published
- 2023
- Full Text
- View/download PDF
18. New HIV diagnoses among adults aged 50 years or older in 31 European countries, 2004–15: an analysis of surveillance data
- Author
-
Schmid, Daniela, Sasse, André, Van Beckhoven, Dominique, Varleva, Tonka, Nemeth Blazic, Tatjana, Hadjihannas, Linos, Koliou, Maria, Maly, Marek, Cowan, Susan, Rüütel, Kristi, Liitsola, Kirsi, Salminen, Mika, Cazein, Françoise, Pillonel, Josiane, Lot, Florence, Gunsenheimer-Bartmeyer, Barbara, Patrinos, Stavros, Paraskeva, Dimitra, Dudas, Maria, Briem, Haraldur, Sigmundsdottir, Gudrun, Igoe, Derval, O'Donnell, Kate, O'Flanagan, Darina, Suligoi, Barbara, Konova, Šarlote, Erne, Sabine, Caplinskiene, Irma, Fischer, Aurélie, Maistre Melillo, Jackie, Melillo, Tanya, Op de Coul, Eline, Blystad, Hans, Rosinska, Magdalena, Aldir, Isabel, Gomes Dias, Helena, Mardarescu, Mariana, Truska, Peter, Klavs, Irena, Díaz, Asunción, Axelsson, Maria, Delpech, Valerie, Tavoschi, Lara, Gomes Dias, Joana, and Pharris, Anastasia
- Published
- 2017
- Full Text
- View/download PDF
19. Long-term virological suppression on first-line efavirenz + tenofovir + emtricitabine/lamivudine for HIV-1
- Author
-
Stirrup, Oliver, Sterne, Jonathan, Dunn, David T., Grabmeier-Pfistershammer, Katharina, Papastamopoulos, Vasileios, Vandenhende, Marie-Anne, Wit, Ferdinand, Porter, Kholoud, Gunsenheimer-Bartmeyer, Barbara, Jarrin, Inma, Garcia, Federico, Fätkenheuer, Gerd, Obel, Niels, Schultze, Anna, Antinori, Andrea, Ceccherini-Silberstein, Francesca, Mussini, Cristina, Chêne, Geneviève, Neesgaard, Bastian, Castagna, Antonella, Kouyos, Roger, De Wit, Stéphane, Sönnerborg, Anders, Sabin, Caroline, Merino, Dolores, Barger, Diana, and Phillips, Andrew
- Published
- 2019
- Full Text
- View/download PDF
20. Are European HIV cohort data within EuroCoord representative of the diagnosed HIV population?
- Author
-
Vourli, Georgia, Pharris, Anastasia, Cazein, Francoise, Costagliola, Dominique, Dabis, Francois, Del Amo, Julia, Delpech, Valerie, Díaz, Asuncion, Girardi, Enrico, Gourlay, Annabelle, Gunsenheimer-Bartmeyer, Barbara, Hernando, Victoria, Nikolopoulos, Georgios, Porter, Kholoud, Rosińska, Magdalena, Sabin, Caroline, Suligoi, Barbara, Supervie, Virginie, Wit, Ferdinand, and Touloumi, Giota
- Published
- 2018
- Full Text
- View/download PDF
21. Are European HIV cohort data within EuroCoord representative of the diagnosed HIV population?
- Author
-
Vourli, Georgia, Pharris, Anastasia, Cazein, Francoise, Costagliola, Dominique, Dabis, Francois, Del Amo, Julia, Delpech, Valerie, Díaz, Asuncion, Girardi, Enrico, Gourlay, Annabelle, Gunsenheimer-Bartmeyer, Barbara, Hernando, Victoria, Nikolopoulos, Georgios, Porter, Kholoud, Rosińska, Magdalena, Sabin, Caroline, Suligoi, Barbara, Supervie, Virginie, Wit, Ferdinand, and Touloumi, Giota
- Published
- 2019
- Full Text
- View/download PDF
22. Characterization of a hepatitis C virus genotype 1 divergent isolate from an HIV-1 coinfected individual in Germany assigned to a new subtype 1o
- Author
-
Wang, Bo, Krüger, Luise, Machnowska, Patrycja, Eshetu, Amare, Gunsenheimer-Bartmeyer, Barbara, Bremer, Viviane, Hauser, Andrea, Bannert, Norbert, and Bock, C.-Thomas
- Published
- 2019
- Full Text
- View/download PDF
23. Schätzung der Anzahl von HIV-Neuinfektionen im Jahr 2021 und der Gesamtzahl von Menschen, die Ende 2021 mit HIV in Deutschland leben
- Author
-
an der Heiden, Matthias, Marcus, Ulrich, Kollan, Christian, Schmidt, Daniel, Koppe, Uwe, Gunsenheimer-Bartmeyer, Barbara, and Bremer, Viviane
- Subjects
AIDS ,HIV ,antiretrovirale Therapie ,ddc:610 ,610 Medizin und Gesundheit ,HIV-Neuinfektionen ,PrEP - Abstract
Die Anzahl der HIV-Neuinfektionen in Deutschland sowie bei Menschen deutscher Herkunft, die sich im Ausland mit HIV infiziert haben, wird für das Jahr 2021 auf 1.800 ge¬schätzt und liegt damit in gleicher Höhe wie 2020 (nach aktualisierter Schätzung ebenfalls etwa 1.800 Neuinfektionen). Der Anteil der diagnostizierten HIV-Infektionen liegt wie im Vorjahr bei etwa 90 %. Der Anteil der antiretroviral therapierten HIV-Infektionen liegt bei 96 %, von denen ebenfalls etwa 96 % als erfolgreich therapiert gelten. Somit sind zumindest zwei der drei Zielwerte des von UNAIDS formulierten „95-95-95-Ziels“ erreicht. Wie das Epidemiologische Bulletin 47/2022 ausführt, bedarf es jedoch weiterer Anstrengungen, um den Rückgang der HIV-Neuinfektionen zu verstetigen: Neben einer Reduktion der HIV-Neuinfektionen muss auch die Anzahl der nicht diagnostizierten Infektionen verringert und eine Therapie für alle in Deutschland lebenden Menschen mit HIV zugänglich gemacht werden.
- Published
- 2022
24. Characterisation of long-term non-progression of HIV-1 infection after seroconversion: a cohort study
- Author
-
van der Helm, Jannie J, Geskus, Ronald, Lodi, Sara, Meyer, Laurence, Schuitemaker, Hanneke, Gunsenheimer-Bartmeyer, Barbara, Monforte, Antonella d'Arminio, Olson, Ashley, Touloumi, Giota, Sabin, Caroline, Porter, Kholoud, and Prins, Maria
- Published
- 2014
- Full Text
- View/download PDF
25. AIDS in the era of antiretroviral therapy: Changes in incidence rates and predictors of AIDS among people living with HIV under clinical care in Germany, a cohort study 1999–2018.
- Author
-
Pantke, Annemarie, Kollan, Christian, Gunsenheimer‐Bartmeyer, Barbara, Jensen, Björn‐Erik Ole, Stephan, Christoph, Degen, Olaf, Schürmann, Dirk, Kurth, Tobias, Bremer, Viviane, and Koppe, Uwe
- Subjects
HIV infection transmission ,AIDS risk factors ,HIV infections ,DISEASE progression ,PUBLIC health surveillance ,CONFIDENCE intervals ,VIRAL load ,AGE distribution ,ANTIRETROVIRAL agents ,RISK assessment ,INFECTIOUS disease transmission ,CD4 lymphocyte count ,DESCRIPTIVE statistics ,PREDICTION models ,AIDS-related opportunistic infections ,AIDS ,SECONDARY analysis ,PROPORTIONAL hazards models - Abstract
Objectives: This study examined the incidence rates and predictive utility of established prognostic factors for the progression to AIDS among people living with HIV under clinical care. Methods: We used data from two observational cohorts of people living with HIV in Germany between 1999 and 2018. The outcome measure was the first AIDS‐defining event that occurred during follow‐up. Incidence rates (IRs) per 1000 person‐years (PY) were calculated by years of follow‐up and calendar periods. We used Cox models in our prediction analyses, including CD4 count, viral load, and age at baseline to estimate the predictive performance. Additionally, we included transmission mode to examine its predictive utility. Results: A total of 23 299 people living with HIV were included in the analyses. Of these, 1832 developed a first AIDS event during follow‐up, constituting an overall rate of 14.6/1000 PY (95% confidence interval [CI] 13.9–15.2). IRs were highest in the first year of follow‐up (45.6/1000 PY, 95% CI 42.6–48.8) and then declined continuously. IRs were highest among people living with HIV who enrolled between 1999 and 2003 (36.1/1000 PY, 95% CI 32.6–40.0). A low CD4 count, high viral load, and older age at baseline increased the likelihood of progressing to AIDS. Adding transmission mode to the models did not improve the predictive performance. Conclusions: The rates of a first AIDS event among people living with HIV have continuously declined in Germany. Health outcomes depend on a person's CD4 count, viral load, and age but not on transmission mode. To further reduce the number of AIDS cases, the focus should be on groups more likely to present in progressed stages of their HIV infection. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
26. HIV-phyloTSI: Subtype-independent estimation of time since HIV-1 infection for cross-sectional measures of population incidence using deep sequence data
- Author
-
Golubchik, Tanya, Abeler-Dörner, Lucie, Hall, Matthew, Wymant, Chris, Bonsall, David, Macintyre-Cockett, George, Thomson, Laura, Baeten, Jared, Celum, Connie, Galiwango, Ronald, Kosloff, Barry, Limbada, Mohammed, Mujugira, Andrew, Mugo, Nelly, Gall, Astrid, Blanquart, François, Bakker, Margreet, Bezemer, Daniela, Ong, Swee Hoe, Albert, Jan, Bannert, Norbert, Fellay, Jacques, Gunsenheimer-Bartmeyer, Barbara, Günthard, Huldrych, Kivelä, Pia, Kouyos, Roger, Meyer, Laurence, Porter, Kholoud, van Sighem, Ard, van der Valk, Mark, Berkhout, Ben, Kellam, Paul, Cornelissen, Marion, Reiss, Peter, Ayles, Helen, Burns, David, Fidler, Sarah, Grabowski, Mary Kate, Hayes, Richard, Herbeck, Joshua, Kagaayi, Joseph, Kaleebu, Pontiano, Lingappa, Jairam, Ssemwanga, Deogratius, Eshleman, Susan, Cohen, Myron, Ratmann, Oliver, Laeyendecker, Oliver, Fraser, Christophe, Blanquart, François, Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, and On behalf of the HPTN 071 (PopART) Phylogenetics protocol team, the BEEHIVE collaboration and the PANGEA consortium
- Subjects
[SDV] Life Sciences [q-bio] ,[SDV]Life Sciences [q-bio] - Abstract
Estimating the time since HIV infection (TSI) at population level is essential for tracking changes in the global HIV epidemic. Most methods for determining duration of infection classify samples into recent and non-recent and are unable to give more granular TSI estimates. These binary classifications have a limited recency time window of several months, therefore requiring large sample sizes, and cannot assess the cumulative impact of an intervention. We developed a Random Forest Regression model, HIV-phyloTSI, that combines measures of within-host diversity and divergence to generate TSI estimates from viral deep-sequencing data, with no need for additional variables. HIV-phyloTSI provides a continuous measure of TSI up to 9 years, with a mean absolute error of less than 12 months overall and less than 5 months for infections with a TSI of up to a year. It performed equally well for all major HIV subtypes based on data from African and European cohorts. We demonstrate how HIV-phyloTSI can be used for incidence estimates on a population level.
- Published
- 2022
- Full Text
- View/download PDF
27. Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load
- Author
-
Zhao, Lele; https://orcid.org/0000-0002-2807-1914, Wymant, Chris; https://orcid.org/0000-0002-9847-8226, Blanquart, François; https://orcid.org/0000-0003-0591-2466, Golubchik, Tanya; https://orcid.org/0000-0003-2765-9828, Gall, Astrid, Bakker, Margreet, Bezemer, Daniela; https://orcid.org/0000-0001-9304-0877, Hall, Matthew, Ong, Swee Hoe; https://orcid.org/0000-0002-3629-5387, Albert, Jan, Bannert, Norbert, Fellay, Jacques; https://orcid.org/0000-0002-8240-939X, Grabowski, M Kate, Gunsenheimer-Bartmeyer, Barbara, Günthard, Huldrych F; https://orcid.org/0000-0002-1142-6723, Kivelä, Pia, Kouyos, Roger D; https://orcid.org/0000-0002-9220-8348, Laeyendecker, Oliver, Meyer, Laurence, Porter, Kholoud, van Sighem, Ard; https://orcid.org/0000-0002-6656-0516, van der Valk, Marc, Berkhout, Ben; https://orcid.org/0000-0002-1905-8486, Kellam, Paul, Cornelissen, Marion, Reiss, Peter, Fraser, Christophe, Ferretti, Luca; https://orcid.org/0000-0001-7578-7301, Zhao, Lele; https://orcid.org/0000-0002-2807-1914, Wymant, Chris; https://orcid.org/0000-0002-9847-8226, Blanquart, François; https://orcid.org/0000-0003-0591-2466, Golubchik, Tanya; https://orcid.org/0000-0003-2765-9828, Gall, Astrid, Bakker, Margreet, Bezemer, Daniela; https://orcid.org/0000-0001-9304-0877, Hall, Matthew, Ong, Swee Hoe; https://orcid.org/0000-0002-3629-5387, Albert, Jan, Bannert, Norbert, Fellay, Jacques; https://orcid.org/0000-0002-8240-939X, Grabowski, M Kate, Gunsenheimer-Bartmeyer, Barbara, Günthard, Huldrych F; https://orcid.org/0000-0002-1142-6723, Kivelä, Pia, Kouyos, Roger D; https://orcid.org/0000-0002-9220-8348, Laeyendecker, Oliver, Meyer, Laurence, Porter, Kholoud, van Sighem, Ard; https://orcid.org/0000-0002-6656-0516, van der Valk, Marc, Berkhout, Ben; https://orcid.org/0000-0002-1905-8486, Kellam, Paul, Cornelissen, Marion, Reiss, Peter, Fraser, Christophe, and Ferretti, Luca; https://orcid.org/0000-0001-7578-7301
- Abstract
Set-point viral load (SPVL), a common measure of human immunodeficiency virus (HIV)-1 virulence, is partially determined by viral genotype. Epidemiological evidence suggests that this viral property has been under stabilising selection, with a typical optimum for the virus between 10$^{4}$ and 10$^{5}$ copies of viral RNA per ml. Here we aimed to detect transmission fitness differences between viruses from individuals with different SPVLs directly from phylogenetic trees inferred from whole-genome sequences. We used the local branching index (LBI) as a proxy for transmission fitness. We found that LBI is more sensitive to differences in infectiousness than to differences in the duration of the infectious state. By analysing subtype-B samples from the Bridging the Evolution and Epidemiology of HIV in Europe project, we inferred a significant positive relationship between SPVL and LBI up to approximately 10$^{5}$ copies/ml, with some evidence for a peak around this value of SPVL. This is evidence of selection against low values of SPVL in HIV-1 subtype-B strains, likely related to lower infectiousness, and perhaps a peak in the transmission fitness in the expected range of SPVL. The less prominent signatures of selection against higher SPVL could be explained by an inherent limit of the method or the deployment of antiretroviral therapy.
- Published
- 2022
28. LILRA3 deletion is a genetic risk factor of HIV infection
- Author
-
Ahrenstorf, Gerrit, Low, Hui Zhi, Kniesch, Katja, Ordonez, David, Meyer-Olson, Dirk, Ahmad, Fareed, Kücherer, Claudia, Gunsenheimer-Bartmeyer, Barbara, Stoll, Matthias, Matthias, Torsten, Schmidt, Reinhold E., and Witte, Torsten
- Published
- 2017
- Full Text
- View/download PDF
29. Correction to: Antiretroviral treatment indications and adherence to the German-Austrian treatment initiation guidelines in the German ClinSurv HIV Cohort between 1999 and 2016
- Author
-
Stecher, Melanie, Schommers, Philipp, Schmidt, Daniel, Kollan, Christian, Gunsenheimer-Bartmeyer, Barbara, Lehmann, Clara, Platten, Martin, Fätkenheuer, Gerd, Vehreschild, Jörg Janne, and ClinSurv Study Group
- Published
- 2019
- Full Text
- View/download PDF
30. HIV, STI and renal function testing frequency and STI history among current users of self-funded HIV pre-exposure prophylaxis, a cross-sectional study, Germany, 2018 and 2019
- Author
-
Koppe, Uwe, primary, Seifried, Janna, additional, Marcus, Ulrich, additional, Albrecht, Stefan, additional, Jansen, Klaus, additional, Jessen, Heiko, additional, Gunsenheimer-Bartmeyer, Barbara, additional, and Bremer, Viviane, additional
- Published
- 2022
- Full Text
- View/download PDF
31. A highly virulent variant of HIV-1 circulating in the Netherlands
- Author
-
Wymant, Chris, Bezemer, Daniela, Blanquart, François, Ferretti, Luca, Gall, Astrid, Hall, Matthew, Golubchik, Tanya, Bakker, Margreet, Ong, Swee Hoe, Zhao, Lele, Bonsall, David, de Cesare, Mariateresa, MacIntyre-Cockett, George, Abeler-Dörner, Lucie, Albert, Jan, Bannert, Norbert, Fellay, Jacques, Grabowski, M Kate, Gunsenheimer-Bartmeyer, Barbara, Günthard, Huldrych F, Kivelä, Pia, Kouyos, Roger D, Laeyendecker, Oliver, Meyer, Laurence, Porter, Kholoud, Ristola, Matti, van Sighem, Ard, Berkhout, Ben, Kellam, Paul, Cornelissen, Marion, Reiss, Peter, Fraser, Christophe, Aubert, V, Battegay, M, Bernasconi, E, Böni, J, Braun, D L, Bucher, H C, Burton-Jeangros, C, Calmy, A, Cavassini, M, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, H, Fux, C A, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, H H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, B Martinez, Marzolini, C, Metzner, K, Müller, N, Nadal, D, Nicca, D, Pantaleo, G, Rauch, A, Regenass, S, Rudin, C, Schöni-Affolter, F, Schmid, P, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Weber, R, Yerly, S, van der Valk, M, Geerlings, S E, Goorhuis, A, Hovius, J W, Lempkes, B, Nellen, F J B, van der Poll, T, Prins, J M, Reiss, P, van Vugt, M, Wiersinga, W J, Wit, F W M N, van Duinen, M, van Eden, J, Hazenberg, A, van Hes, A M H, Pijnappel, F J J, Smalhout, S Y, Weijsenfeld, A M, Jurriaans, S, Back, N K T, Zaaijer, H L, Berkhout, B, Cornelissen, M T E, Schinkel, C J, Wolthers, K C, Peters, E J G, van Agtmael, M A, Autar, R S, Bomers, M, Sigaloff, K C E, Heitmuller, M, Laan, L M, Ang, C W, van Houdt, R, Jonges, M, Kuijpers, T W, Pajkrt, D, Scherpbier, H J, de Boer, C, van der Plas, A, van den Berge, M, Stegeman, A, Baas, S, Hage de Looff, L, Buiting, A, Reuwer, A, Veenemans, J, Wintermans, B, Pronk, M J H, Ammerlaan, H S M, van den Bersselaar, D N J, de Munnik, E S, Deiman, B, Jansz, A R, Scharnhorst, V, Tjhie, J, Wegdam, M C A, van Eeden, A, Nellen, J, Brokking, W, Elsenburg, L J M, Nobel, H, van Kasteren, M E E, Berrevoets, M A H, Brouwer, A E, Adams, A, van Erve, R, de Kruijf-van de Wiel, B A F M, Keelan-Phaf, S, van der Ven, B, Buiting, A G M, Murck, J L, de Vries-Sluijs, T E M S, Bax, H I, van Gorp, E C M, de Jong-Peltenburg, N C, de Mendonç A Melo, M, van Nood, E, Nouwen, J L, Rijnders, B J A, Rokx, C, Schurink, C A M, Slobbe, L, Verbon, A, Bassant, N, van Beek, J E A, Vriesde, M, van Zonneveld, L M, de Groot, J, Boucher, C A B, Koopmans, M P G, van Kampen, J J A, Fraaij, P L A, van Rossum, A M C, Vermont, C L, van der Knaap, L C, Visser, E, Branger, J, Douma, R A, Cents-Bosma, A S, Duijf-van de Ven, C J H M, Schippers, E F, van Nieuwkoop, C, van Ijperen, J M, Geilings, J, van der Hut, G, van Burgel, N D, Leyten, E M S, Gelinck, L B S, Mollema, F, Davids-Veldhuis, S, Tearno, C, Wildenbeest, G S, Heikens, E, Groeneveld, P H P, Bouwhuis, J W, Lammers, A J J, Kraan, S, van Hulzen, A G W, Kruiper, M S M, van der Bliek, G L, Bor, P C J, Debast, S B, Wagenvoort, G H J, Kroon, F P, de Boer, M G J, Jolink, H, Lambregts, M M C, Roukens, A H E, Scheper, H, Dorama, W, van Holten, N, Claas, E C J, Wessels, E, den Hollander, J G, El Moussaoui, R, Pogany, K, Smit, J V, Struik-Kalkman, D, van Niekerk, T, Pontesilli, O, Lowe, S H, Oude Lashof, A M L, Posthouwer, D, van Wolfswinkel, M E, Ackens, R P, Burgers, K, Schippers, J, Weijenberg-Maes, B, van Loo, I H M, Havenith, T R A, van Vonderen, M G A, Kampschreur, L M, Faber, S, Steeman-Bouma, R, Al Moujahid, A, Kootstra, G J, Delsing, C E, van der Burg-van de Plas, M, Scheiberlich, L, Kortmann, W, van Twillert, G, Renckens, R, Ruiter-Pronk, D, van Truijen-Oud, F A, Cohen Stuart, J W T, Jansen, E R, Hoogewerf, M, Rozemeijer, W, van der Reijden, W A, Sinnige, J C, Brinkman, K, van den Berk, G E L, Blok, W L, Lettinga, K D, de Regt, M, Schouten, W E M, Stalenhoef, J E, Veenstra, J, Vrouenraets, S M E, Blaauw, H, Geerders, G F, Kleene, M J, Kok, M, Knapen, M, van der Meché, I B, Mulder-Seeleman, E, Toonen, A J M, Wijnands, S, Wttewaal, E, Kwa, D, van Crevel, R, van Aerde, K, Dofferhoff, A S M, Henriet, S S V, Ter Hofstede, H J M, Hoogerwerf, J, Keuter, M, Richel, O, Albers, M, Grintjes-Huisman, K J T, de Haan, M, Marneef, M, Strik-Albers, R, Rahamat-Langendoen, J, Stelma, F F, Burger, D, Gisolf, E H, Hassing, R J, Claassen, M, Ter Beest, G, van Bentum, P H M, Langebeek, N, Tiemessen, R, Swanink, C M A, van Lelyveld, S F L, Soetekouw, R, van der Prijt, L M M, van der Swaluw, J, Bermon, N, Jansen, R, Herpers, B L, Veenendaal, D, Verhagen, D W M, Lauw, F N, van Broekhuizen, M C, van Wijk, M, Bierman, W F W, Bakker, M, Kleinnijenhuis, J, Kloeze, E, Middel, A, Postma, D F, Schölvinck, E H, Stienstra, Y, Verhage, A R, Wouthuyzen-Bakker, M, Boonstra, A, de Groot-de Jonge, H, van der Meulen, P A, de Weerd, D A, Niesters, H G M, van Leer-Buter, C C, Knoester, M, Hoepelman, A I M, Arends, J E, Barth, R E, Bruns, A H W, Ellerbroek, P M, Mudrikova, T, Oosterheert, J J, Schadd, E M, van Welzen, B J, Aarsman, K, Griffioen-van Santen, B M G, de Kroon, I, van Berkel, M, van Rooijen, C S A M, Schuurman, R, Verduyn-Lunel, F, Wensing, A M J, Bont, L J, Geelen, S P M, Loeffen, Y G T, Wolfs, T F W, Nauta, N, Rooijakkers, E O W, Holtsema, H, Voigt, R, van de Wetering, D, Alberto, A, van der Meer, I, Rosingh, A, Halaby, T, Zaheri, S, Boyd, A C, Bezemer, D O, van Sighem, A I, Smit, C, Hillebregt, M, de Jong, A, Woudstra, T, Bergsma, D, Meijering, R, van de Sande, L, Rutkens, T, van der Vliet, S, de Groot, L, van den Akker, M, Bakker, Y, El Berkaoui, A, Bezemer, M, Brétin, N, Djoechro, E, Groters, M, Kruijne, E, Lelivelt, K J, Lodewijk, C, Lucas, E, Munjishvili, L, Paling, F, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Schoorl, M, Schnörr, P, Scheigrond, A, Tuijn, E, Veenenberg, L, Visser, K M, Witte, E C, Van Frankenhuijsen, Maartje, Allegre, Thierry, Makhloufi, Djamila, Livrozet, Jean-Michel, Chiarello, Pierre, Godinot, Mathieu, Brunel-Dalmas, Florence, Gibert, Sylvie, Trepo, Christian, Peyramond, Dominique, Miailhes, Patrick, Koffi, Joseph, Thoirain, Valérie, Brochier, Corinne, Baudry, Thomas, Pailhes, Sylvie, Lafeuillade, Alain, Philip, Gisèle, Hittinger, Gilles, Assi, Assi, Lambry, Véronique, Rosenthal, Eric, Naqvi, Alissa, Dunais, Brigitte, Cua, Eric, Pradier, Christian, Durant, Jacques, Joulie, Aline, Quinsat, Denis, Tempesta, Serge, Ravaux, Isabelle, Martin, Isabelle Poizot, Faucher, Olivia, Cloarec, Nicolas, Champagne, Hélène, Pichancourt, Gilles, Morlat, Philippe, Pistone, Thierry, Bonnet, Fabrice, Mercie, Patrick, Faure, Isabelle, Hessamfar, Mojgan, Malvy, Denis, Lacoste, Denis, Pertusa, Marie-Carmen, Vandenhende, Marie-Anne, Bernard, Noëlle, Paccalin, François, Martell, Cédric, Roger-Schmelz, Julien, Receveur, Marie-Catherine, Duffau, Pierre, Dondia, Denis, Ribeiro, Emmanuel, Caltado, Sabrina, Neau, Didier, Dupont, Michel, Dutronc, Hervé, Dauchy, Frédéric, Cazanave, Charles, Vareil, Marc-Olivier, Wirth, Gaétane, Le Puil, Séverine, Pellegrin, Jean-Luc, Raymond, Isabelle, Viallard, Jean-François, Chaigne de Lalande, Severin, Garipuy, Daniel, Delobel, Pierre, Obadia, Martine, Cuzin, Lise, Alvarez, Muriel, Biezunski, Noemie, Porte, Lydie, Massip, Patrice, Debard, Alexa, Balsarin, Florence, Lagarrigue, Myriam, Prevoteau du Clary, François, Aquilina, Christian, Reynes, Jacques, Baillat, Vincent, Merle, Corinne, Lemoing, Vincent, Atoui, Nadine, Makinson, Alain, Jacquet, Jean Marc, Psomas, Christina, Tramoni, Christine, Aumaitre, Hugues, Saada, Mathieu, Medus, Marie, Malet, Martine, Eden, Aurélia, Neuville, Ségolène, Ferreyra, Milagros, Sotto, Albert, Barbuat, Claudine, Rouanet, Isabelle, Leureillard, Didier, Mauboussin, Jean-Marc, Lechiche, Catherine, Donsesco, Régine, Cabie, André, Abel, Sylvie, Pierre-Francois, Sandrine, Batala, Anne-Sophie, Cerland, Christophe, Rangom, Camille, Theresine, Nadine, Hoen, Bruno, Lamaury, Isabelle, Fabre, Isabelle, Schepers, Kinda, Curlier, Elodie, Ouissa, Rachida, Gaud, Catherine, Ricaud, Carole, Rodet, Roland, Wartel, Guillaume, Sautron, Carmele, Beck-Wirth, Geneviève, Michel, Catherine, Beck, Charles, Halna, Jean-Michel, Kowalczyk, Jakub, Benomar, Meryem, Drobacheff-Thiebaut, Christine, Chirouze, Catherine, Faucher, Jean-François, Parcelier, François, Foltzer, Adeline, Haffner-Mauvais, Cécile, Hustache Mathieu, Mathieu, Proust, Aurélie, Piroth, Lionel, Chavanet, Pascal, Duong, Michel, Buisson, Marielle, Waldner, Anne, Mahy, Sophie, Gohier, Sandrine, Croisier, Delphine, May, Thierry, Delestan, Mikael, Andre, Marie, Zadeh, Mahsa Mohseni, Martinot, Martin, Rosolen, Béatrice, Pachart, Anne, Martha, Benoît, Jeunet, Noëlle, Rey, David, Cheneau, Christine, Partisani, Maria, Priester, Michèle, Bernard-Henry, Claudine, Batard, Marie-Laure, Fischer, Patricia, Berger, Jean-Luc, Kmiec, Isabelle, Robineau, Olivier, Huleux, Thomas, Ajana, Faïza, Alcaraz, Isabelle, Allienne, Christophe, Baclet, Véronique, Meybeck, Agnès, Valette, Michel, Viget, Nathalie, Aissi, Emmanuelle, Biekre, Raphael, Cornavin, Pauline, Merrien, Dominique, Seghezzi, Jean-Christophe, Machado, Moise, Diab, Georges, Raffi, François, Bonnet, Bénédicte, Allavena, Clotilde, Grossi, Olivier, Reliquet, Véronique, Billaud, Eric, Brunet, Cecile, Bouchez, Sabelline, Morineau-Le Houssine, Pascale, Sauser, Fabienne, Boutoille, David, Besnier, Michel, Hue, Hervé, Hall, Nolwenn, Brosseau, Delphine, Souala, Faouzi, Michelet, Christian, Tattevin, Pierre, Arvieux, Cédric, Revest, Matthieu, Leroy, Helene, Chapplain, Jean-Marc, Dupont, Matthieu, Fily, Fabien, Patra-Delo, Solène, Lefeuvre, Céline, Bernard, Louis, Bastides, Frédéric, Nau, Pascale, Verdon, Renaud, de la Blanchardiere, Arnaud, Martin, Anne, Feret, Philippe, Geffray, Loïk, Daniel, Corinne, Rohan, Jennifer, Fialaire, Pascale, Chennebault, Jean Marie, Rabier, Valérie, Abgueguen, Pierre, Rehaiem, Sami, Luycx, Odile, Niault, Mathilde, Moreau, Philippe, Poinsignon, Yves, Goussef, Marie, Mouton-Rioux, Virginie, Houlbert, Dominique, Alvarez-Huve, Sandrine, Barbe, Frédérique, Haret, Sophie, Perre, Philippe, Leantez-Nainville, Sophie, Esnault, Jean-Luc, Guimard, Thomas, Suaud, Isabelle, Girard, Jean-Jacques, Simonet, Véronique, Debab, Yasmine, Schmit, Jean-Luc, Jacomet, Christine, Weinberck, Pierre, Genet, Claire, Pinet, Pauline, Ducroix, Sophie, Durox, Hélène, Denes, Éric, Abraham, Bruno, Gourdon, Florence, Antoniotti, Odile, Molina, Jean-Michel, Ferret, Samuel, Lascoux-Combe, Caroline, Lafaurie, Matthieu, Colin de Verdiere, Nathalie, Ponscarme, Diane, De Castro, Nathalie, Aslan, Alexandre, Rozenbaum, Willy, Pintado, Claire, Clavel, François, Taulera, Olivier, Gatey, Caroline, Munier, Anne-Lise, Gazaigne, Sandrine, Penot, Pauline, Conort, Guillaume, Lerolle, Nathalie, Leplatois, Anne, Balausine, Stéphanie, Delgado, Jeannine, Timsit, Julie, Tabet, Magda, Gerard, Laurence, Girard, Pierre-Marie, Picard, Odile, Tredup, Jürgen, Bollens, Diane, Valin, Nadia, Campa, Pauline, Bottero, Julie, Lefebvre, Benedicte, Tourneur, Muriel, Fonquernie, Laurent, Wemmert, Charlotte, Lagneau, Jean-Luc, Yazdanpanah, Yazdan, Phung, Bao, Pinto, Adriana, Vallois, Dorothée, Cabras, Ornella, Louni, Françoise, Pialoux, Gilles, Lyavanc, Thomas, Berrebi, Valérie, Chas, Julie, Lenagat, Sophie, Rami, Agathe, Diemer, Myriam, Parrinello, Maguy, Depond, Audrey, Salmon, Dominique, Guillevin, Loïc, Tahi, Tassadit, Belarbi, Linda, Loulergue, Pierre, Zak Dit Zbar, Olivier, Launay, Odile, Silbermann, Benjamin, Leport, Catherine, Alagna, Laura, Pietri, Marie-Pierre, Simon, Anne, Bonmarchand, Manuela, Amirat, Naouel, Pichon, François, Kirstetter, Myriam, Katlama, Christine, Valantin, Marc Antoine, Tubiana, Roland, Caby, Fabienne, Schneider, Luminita, Ktorza, Nadine, Calin, Ruxandra, Merlet, Audrey, Ben Abdallah, Saadia, Weiss, Laurence, Buisson, Martin, Batisse, Dominique, Karmochine, Marina, Pavie, Juliette, Minozzi, Catherine, Jayle, Didier, Castel, Philippe, Derouineau, Jean, Kousignan, Pascale, Eliazevitch, Murielle, Pierre, Isabelle, Collias, Lio, Viard, Jean-Paul, Gilquin, Jacques, Sobel, Alain, Slama, Laurence, Ghosn, Jade, Hadacek, Blanka, Thu-Huyn, Nugyen, Nait-Ighil, Lella, Cros, Agnes, Maignan, Aline, Duvivier, Claudine, Consigny, Paul Henri, Lanternier, Fanny, Shoai-Tehrani, Michka, Touam, Fatima, Jerbi, Saadia, Bodard, Loïc, Jung, Corinne, Goujard, Cécile, Quertainmont, Yann, Duracinsky, Martin, Segeral, Olivier, Blanc, Arnaud, Peretti, Delphine, Cheret, Antoine, Chantalat, Christelle, Dulucq, Marie Josée, Levy, Yves, Lelievre, Jean Daniel, Lascaux, Anne Sophie, Dumont, Cécile, Boue, François, Chambrin, Véronique, Abgrall, Sophie, Kansau, Imad, Raho-Moussa, Mariem, De Truchis, Pierre, Dinh, Aurélien, Davido, Benjamin, Marigot, Dhiba, Berthe, Huguette, Devidas, Alain, Chevojon, Pierre, Chabrol, Amélie, Agher, Nouara, Lemercier, Yvon, Chaix, Fabrice, Turpault, Isabelle, Bouchaud, Olivier, Honore, Patricia, Rouveix, Elisabeth, Reimann, Evelyne, Belan, Alix Greder, Godin Collet, Claire, Souak, Safia, Mortier, Emmanuel, Bloch, Martine, Simonpoli, Anne-Marie, Manceron, Véronique, Cahitte, Isabelle, Hiraux, Emmanuel, Lafon, Erik, Cordonnier, François, Zeng, Ai-Feng, Zucman, David, Majerholc, Catherine, Bornarel, Dominique, Uludag, Agnès, Gellen-Dautremer, Justine, Lefort, Agnès, Bazin, Christine, Daneluzzi, Vincent, Gerbe, Juliette, Jeantils, Vincent, Coupard, Mélissa, Patey, Olivier, Bantsimba, Jonas, Delllion, Sophie, Paz, Pauline Caraux, Cazenave, Benoit, Richier, Laurent, Garrait, Valérie, Delacroix, Isabelle, Elharrar, Brigitte, Vittecoq, Daniel, Bolliot, Claudine, Lepretre, Annie, Genet, Philippe, Masse, Virginie, Perrone, Véronique, Boussard, Jean-Luc, Chardon, Patricia, Froguel, Eric, Simon, Philippe, Tassi, Sylvie, Avettand Fenoel, Véronique, Barin, Francis, Bourgeois, Christine, Cardon, Fanny, Chaix, Marie-Laure, Delfraissy, Jean François, Essat, Asma, Fischer, Hugues, Lecuroux, Camille, Petrov-Sanchez, Ventzislava, Rouzioux, Christine, Saez-Cirion, Asier, Seng, Rémonie, Kuldanek, Kristin, Mullaney, Scott, Young, Carmel, Zucchetti, Antonella, Bevan, Margaret-Ann, McKernan, Sinead, Wandolo, Emily, Richardson, Celia, Youssef, Elaney, Green, Pippa, Faulkner, Sue, Faville, Rebecca, Herman, Sandra, Care, Christine, Blackman, Helen, Bellenger, Katharine, Fairbrother, Keith, Phillips, Andrew, Babiker, Abdel, Delpech, Valerie, Fidler, S, Clarke, Mindy, Fox, Julie, Gilson, R, Goldberg, David, Hawkins, David, Johnson, Anne, Johnson, Margaret, McLean, Ken, Nastouli, Eleni, Post, Frank, Kennedy, N, Pritchard, J, Andrady, U, Rajda, N, Donnelly, C, McKernan, S, Drake, S, Gilleran, G, White, D, Ross, J, Harding, J, Faville, R, Sweeney, J, Flegg, P, Toomer, S, Wilding, H, Woodward, R, Dean, G, Richardson, C, Perry, N, Gompels, M, Jennings, L, Bansaal, D, Browing, M, Connolly, L, Stanley, B, Estreich, S, Magdy, A, O'Mahony, C, Fraser, P, Jebakumar, S P R, David, L, Mette, R, Summerfield, H, Evans, M, White, C, Robertson, R, Lean, C, Morris, S, Winter, A, Faulkner, S, Goorney, B, Howard, L, Fairley, I, Stemp, C, Short, L, Gomez, M, Young, F, Roberts, M, Green, S, Sivakumar, K, Minton, J, Siminoni, A, Calderwood, J, Greenhough, D, DeSouza, C, Muthern, Lisa, Orkin, C, Murphy, S, Truvedi, M, McLean, K, Hawkins, D, Higgs, C, Moyes, A, Antonucci, S, McCormack, S, Lynn, W, Bevan, M, Fox, J, Teague, A, Anderson, J, Mguni, S, Post, F, Campbell, L, Mazhude, C, Russell, H, Carrick, G, Ainsworth, J, Waters, A, Byrne, P, Johnson, M, Kuldanek, K, Mullaney, S, Lawlor, V, Melville, R, Sukthankar, A, Thorpe, S, Murphy, C, Wilkins, E, Ahmad, S, Green, P, Tayal, S, Ong, E, Meaden, J, Riddell, L, Loay, D, Peacock, K, Blackman, H, Harindra, V, Saeed, A M, Allen, S, Natarajan, U, Williams, O, Lacey, H, Care, C, Bowman, C, Herman, S, Devendra, S V, Wither, J, Bridgwood, A, Singh, G, Bushby, S, Kellock, D, Young, S, Rooney, G, Snart, B, Currie, J, Fitzgerald, M, Arumainayyagam, J, Chandramani, S, Rajamanoharan, S, Robinson, T, Taylor, B, Brewer, C, Mayr, Christoph, Schmidt, Wolfgang, Speidel, Andrea, Strohbach, Frank, Arastéh, Keikawus, Cordes, Christiane, Stündel, Manfred, Claus, Jörg, Baumgarten, Axel, Carganico, Andreas, Ingiliz, Patrick, Dupke, Stephan, Freiwald, Matthias, Rausch, Michael, Moll, Arend, Schleehauf, Dorothea, Hintsche, Bettina, Klausen, Gerd, Jessen, Heiko, Jessen, Arne, Köppe, Siegfried, Kreckel, Peter, Schranz, Dietmar, Fischer, Klaus, Schulbin, Hubert, Speer, Miriam, Glaunsinger, Tobias, Wicke, Thomas, Bieniek, Bernhard, Hillenbrand, Heribert, Schlote, Frank, Lauenroth-Mai, Elke, Schuler, Christoph, Schürmann, Dirk, Wesselmann, Hans, Brockmeyer, Norbert, Gehring, Peter, Schmalöer, Dirk, Hower, Martin, Spornraft-Ragaller, Petra, Häussinger, Dieter, Reuter, Stefan, Esser, Stefan, Markus, Rudolf, Kreft, Burkhard, Berzow, Dirk, Christl, Andreas, Meyer, Andreas, Plettenberg, Andreas, Stoehr, Albrecht, Graefe, Katrin, Lorenzen, Thore, Adam, Axel, Schewe, Knut, Weitner, Lutwin, Fenske, Stefan, Hansen, Stefan, Stellbrink, Hans-Jürgen, Wiemer, Dorothea, Hertling, Sandra, Schmidt, Reinhold, Arbter, Peter, Claus, Bernd, Galle, Peter, Jäger, Hans, Jä Gel-Guedes, Eva, Postel, Nils, Fröschl, Monika, Spinner, Christoph, Bogner, Johannes, Salzberger, Bernd, Schölmerich, Jürgen, Audebert, Franz, Marquardt, Ties, Schaffert, Andreas, Schnaitmann, Eiko, Trein, Andreas, Frietsch, Bernhard, Müller, Marcus, Ulmer, Albrecht, Detering-Hübner, Barbara, Kern, Peter, Schubert, Franz, Dehn, Günther, Schreiber, Maria, Güler, Cengiz, Schmidt, Daniel, Meixenberger, Karolin, Medical Microbiology & Infectious Diseases, Internal Medicine, Virology, Pediatrics, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Global Health, Infectious diseases, APH - Aging & Later Life, Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Internal medicine, VU University medical center, Surgery, AMS - Rehabilitation & Development, APH - Quality of Care, Psychiatry, Pediatric surgery, Neurology, Public and occupational health, APH - Mental Health, Pathology, Cardiology, ACS - Heart failure & arrhythmias, Anesthesiology, IOO, Rehabilitation medicine, Obstetrics and gynaecology, General practice, Gastroenterology and hepatology, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Medical oncology laboratory, Hematology, Epidemiology and Data Science, Physiology, Microbes in Health and Disease (MHD), University of Oxford, Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Amsterdam UMC - Amsterdam University Medical Center, The Wellcome Trust Sanger Institute [Cambridge], Karolinska Institutet [Stockholm], Robert Koch Institute [Berlin] (RKI), Ecole Polytechnique Fédérale de Lausanne (EPFL), Johns Hopkins University (JHU), Universität Zürich [Zürich] = University of Zurich (UZH), Helsinki University Hospital [Helsinki, Finlande], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University College of London [London] (UCL), Kymab Ltd, Cambridge, England, Institut Pasteur [Paris] (IP), This study was funded by ERC Advanced Grant PBDR-339251 and a Li Ka Shing Foundation grant, both awarded to C.F. The ATHENA Cohort is managed by Stichting HIV Monitoring and supported by a grant from the Dutch Ministry of Health, Welfare and Sport through the Centre for Infectious Disease Control of the National Institute for Public Health and the Environment., We thank K. Fransen and G. Vanham for help with the Belgian data, O. Ratmann for help in identifying the Dutch clusters, K. Kusejko for testing for additional VB individuals in the SHCS, B. Foley for help with genome sharing, B. Dearlove and L. Thomson for help with software, and J. Herbeck and three other reviewers for helpful suggestions., Contributors and affiliations are listed in the supplementary materials., Department of Medicine, University of Helsinki, Infektiosairauksien yksikkö, HUS Inflammation Center, and Clinicum
- Subjects
Adult ,Male ,HIV-1/genetics ,Genotype ,Anti-HIV Agents ,Evolution ,[SDV]Life Sciences [q-bio] ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,HIV Infections/drug therapy ,selection ,HIV Infections ,Genome, Viral ,heritability ,epidemic ,human-immunodeficiency-virus ,Evolution, Molecular ,SDG 3 - Good Health and Well-being ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Humans ,Viral ,Phylogeny ,Netherlands ,Multidisciplinary ,Genome ,model ,Virulence ,transmission ,Molecular ,setpoint viral load ,reverse-transcriptase ,dynamics ,Viral Load ,CD4 Lymphocyte Count ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,3121 General medicine, internal medicine and other clinical medicine ,Anti-HIV Agents/therapeutic use ,Mutation ,HIV-1 ,Female ,progression - Abstract
Comment in Does HIV-1 virulence matter in the ART era? Lewitus E, Rolland M. Med (N Y). 2022 Apr 8;3(4):217-219. doi: 10.1016/j.medj.2022.03.003. PMID: 35590149; International audience; We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.
- Published
- 2022
- Full Text
- View/download PDF
32. Additional file 2 of The impact of regional socioeconomic deprivation on the timing of HIV diagnosis: a cross-sectional study in Germany
- Author
-
Pantke, Annemarie, Hoebel, Jens, an der Heiden, Matthias, Michalski, Niels, Gunsenheimer-Bartmeyer, Barbara, Hanke, Kirsten, Bannert, Norbert, Bremer, Viviane, and Koppe, Uwe
- Abstract
Additional file 2: Figure S2. Flowchart.
- Published
- 2022
- Full Text
- View/download PDF
33. Additional file 1 of The impact of regional socioeconomic deprivation on the timing of HIV diagnosis: a cross-sectional study in Germany
- Author
-
Pantke, Annemarie, Hoebel, Jens, an der Heiden, Matthias, Michalski, Niels, Gunsenheimer-Bartmeyer, Barbara, Hanke, Kirsten, Bannert, Norbert, Bremer, Viviane, and Koppe, Uwe
- Abstract
Additional file 1: Figure S1. Directed acyclic graph (DAG).
- Published
- 2022
- Full Text
- View/download PDF
34. Additional file 3 of The impact of regional socioeconomic deprivation on the timing of HIV diagnosis: a cross-sectional study in Germany
- Author
-
Pantke, Annemarie, Hoebel, Jens, an der Heiden, Matthias, Michalski, Niels, Gunsenheimer-Bartmeyer, Barbara, Hanke, Kirsten, Bannert, Norbert, Bremer, Viviane, and Koppe, Uwe
- Abstract
Additional file 3: Tables S1 and S2. Sensitivity analyses.
- Published
- 2022
- Full Text
- View/download PDF
35. Additional file 4 of The impact of regional socioeconomic deprivation on the timing of HIV diagnosis: a cross-sectional study in Germany
- Author
-
Pantke, Annemarie, Hoebel, Jens, an der Heiden, Matthias, Michalski, Niels, Gunsenheimer-Bartmeyer, Barbara, Hanke, Kirsten, Bannert, Norbert, Bremer, Viviane, and Koppe, Uwe
- Abstract
Additional file 4: Tables S3���S8. Sensitivity analyses.
- Published
- 2022
- Full Text
- View/download PDF
36. Phylogenetic estimation of the viral fitness landscape of HIV-1 set-point viral load
- Author
-
Zhao, Lele, Wymant, Chris, Blanquart, François, Golubchik, Tanya, Gall, Astrid, Bakker, Margreet, Bezemer, Daniela, Hall, Matthew, Hoe Ong, Swee, Albert, Jan, Bannert, Norbert, Fellay, Jacques, Grabowski, M. Kate, Gunsenheimer-Bartmeyer, Barbara, Günthard, Huldrych F., Kivelä, Pia, Kouyos, Roger D., Laeyendecker, Oliver, Meyer, Laurence, Porter, Kholoud, van Sighem, Ard, van der Valk, Marc, Berkhout, Ben, Kellam, Paul, Cornelissen, Marion, Reiss, Peter, Fraser, Christophe, Ferretti, Luca, on behalf of the BEEHIVE Collaboration, Blanquart, François, University of Oxford, Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), European Molecular Biology Laboratory (EMBL), Amsterdam UMC - Amsterdam University Medical Center, Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), The Wellcome Trust Sanger Institute [Cambridge], Karolinska Institutet [Stockholm], Robert Koch Institute [Berlin] (RKI), Johns Hopkins University (JHU), University hospital of Zurich [Zurich], Helsinki University Hospital [Finland] (HUS), National Institutes of Health [Bethesda] (NIH), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University College of London [London] (UCL), Kymab Ltd, Cambridge, England, Medical Microbiology and Infection Prevention, Infectious diseases, AII - Infectious diseases, APH - Digital Health, APH - Personalized Medicine, APH - Global Health, Global Health, APH - Aging & Later Life, University of Zurich, Ferretti, Luca, HUS Internal Medicine and Rehabilitation, Department of Medicine, University of Helsinki, and Infektiosairauksien yksikkö
- Subjects
11832 Microbiology and virology ,between-host evolution ,diagnosis ,tansmission fitness ,[SDV]Life Sciences [q-bio] ,2404 Microbiology ,antiretroviral therapy ,610 Medicine & health ,heritability ,Microbiology ,initiation ,10234 Clinic for Infectious Diseases ,virulence ,[SDV] Life Sciences [q-bio] ,Virology ,2406 Virology ,HIV-1 ,rna ,ddc:610 ,3111 Biomedicine ,set-point viral load ,610 Medizin und Gesundheit ,prognostic markers ,time - Abstract
Set-point viral load (SPVL), a common measure of human immunodeficiency virus (HIV)-1 virulence, is partially determined by viral genotype. Epidemiological evidence suggests that this viral property has been under stabilising selection, with a typical optimum for the virus between 104 and 105 copies of viral RNA per ml. Here we aimed to detect transmission fitness differences between viruses from individuals with different SPVLs directly from phylogenetic trees inferred from whole-genome sequences. We used the local branching index (LBI) as a proxy for transmission fitness. We found that LBI is more sensitive to differences in infectiousness than to differences in the duration of the infectious state. By analysing subtype-B samples from the Bridging the Evolution and Epidemiology of HIV in Europe project, we inferred a significant positive relationship between SPVL and LBI up to approximately 105 copies/ml, with some evidence for a peak around this value of SPVL. This is evidence of selection against low values of SPVL in HIV-1 subtype-B strains, likely related to lower infectiousness, and perhaps a peak in the transmission fitness in the expected range of SPVL. The less prominent signatures of selection against higher SPVL could be explained by an inherent limit of the method or the deployment of antiretroviral therapy.
- Published
- 2022
- Full Text
- View/download PDF
37. Similar Sexual Behaviour yet Different Outcomes: Comparing Trans and Gender Diverse and Cis PrEP Users in Germany Based on the Outcomes of the PrApp Study
- Author
-
Appenroth, Max Nicolai, primary, Marcus, Ulrich, additional, Albrecht, Stefan, additional, Jansen, Klaus, additional, Gunsenheimer-Bartmeyer, Barbara, additional, Bremer, Viviane, additional, and Koppe, Uwe, additional
- Published
- 2022
- Full Text
- View/download PDF
38. Sch��tzung der Zahl der HIV-Neuinfektionen und der Gesamtzahl von Menschen mit HIV in Deutschland, Stand Ende 2020
- Author
-
an der Heiden, Matthias, Marcus, Ulrich, Kollan, Christian, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, and Bremer, Viviane
- Subjects
AIDS ,HIV ,antiretrovirale Therapie ,ddc:610 ,610 Medizin und Gesundheit ,HIV-Neuinfektionen ,PrEP - Abstract
Die Zahl der HIV-Neuinfektionen in Deutschland sowie bei Menschen deutscher Herkunft, die sich im Ausland mit HIV infiziert haben, wird 2020 auf 2.000 gesch��tzt und nimmt damit im Vergleich zum Vorjahr ab. Die Zahl der Menschen mit einer HIV-Infektion stieg auf 91.400. Wie das Epidemiologische Bulletin 47/2021 berichtet, erreichte Deutschland 2020 alle Vorgaben des von UNAIDS formulierten ���90-90-90 Ziels���: Bereits seit 2011 liegt der Anteil der antiretroviral therapierten HIV-Infektionen bei ��ber 90%, von denen wiederum etwa 96% als erfolgreich therapiert gelten. Zus��tzlich wurden 2020 nun erstmals auch etwa 90% der HIV-Infizierten diagnostiziert.
- Published
- 2021
- Full Text
- View/download PDF
39. HIV-Jahresbericht 2019–2020
- Author
-
Marcus, Ulrich, Kollan, Christian, Gunsenheimer-Bartmeyer, Barbara, and Bremer, Viviane
- Subjects
AIDS ,Infektionsschutzgesetz ,HIV ,Jahresbericht ,ddc:610 ,Meldedaten ,610 Medizin und Gesundheit - Abstract
Gemäß § 7 Abs. 3 Infektionsschutzgesetz (IfSG) ist der direkte oder indirekte Nachweis einer Infektion mit dem Humanen Immundefizienz-Virus (HIV) nichtnamentlich unmittelbar an das Robert Koch-Institut (RKI) zu melden. Dem RKI wurden für das Jahr 2019 insgesamt 3.111 und bis zum 01.06.2021 für das Jahr 2020 insge¬samt 2.454 gesicherte HIV-Neudiagnosen gemeldet. Dies entspricht einer Zunahme um 8 % von 2018 auf 2019 und einem Rückgang um 21% von 2019 auf 2020. Wahrscheinlich hat die COVID-19-Pandemie durch verschiedene Faktoren zum Rückgang der HIV-Neudiagnosen im Jahr 2020 beigetragen. Der HIV-Jahresbericht 2019 – 2020 gibt neben der Auskunft über die aktuellen HIV-Meldedaten eine Übersicht zu Herkunfts- und Infektionsregionen und eine Betrachtung nach Geschlecht sowie nach Transmissions¬wegen.
- Published
- 2021
40. Correction to: Treatment modifcation after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005–2017
- Author
-
Stecher, Melanie, Schommers, Philipp Frederik, Kollan, Christian, Stoll, Matthias, Kuhlendahl, Frieder-Johan, Stellbrink, Hans‑Jürgen, Wasmuth, Jan‑Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Schürmann, Dirk, Degen, Olaf, Horst, Heinz August, Hoffmann, Christian, Jensen, Björn-Erik Ole, Schwarze-Zander, Carolynne, Platten, Martin, Fätkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, Vehreschild, Jörg Janne, and ClinSurv Study Group
- Subjects
ddc:610 - Abstract
Correction to: Infection (2020) 48:723–733 https://doi.org/10.1007/s15010-020-01469-6. The original version of this article unfortunately contained a mistake. In this article the authors Dirk Schürmann at affiliation Charité, University Medicine, Berlin, Olaf Degen at affiliation University Clinic Hamburg Eppendorf, Hamburg and Heinz-August Horst at affiliation University Hospital Schleswig–Holstein, Kiel, Germany were missing from the author list. The original article has been corrected.
- Published
- 2021
41. The impact of regional socioeconomic deprivation on late HIV diagnoses: a cross-sectional study in Germany
- Author
-
PANTKE, Annemarie, primary, KOPPE, Uwe, additional, HEIDEN, Matthias AN DER, additional, MICHALSKI, Niels, additional, HOEBEL, Jens, additional, BREMER, Viviane, additional, GUNSENHEIMER-BARTMEYER, Barbara, additional, BANNERT, Norbert, additional, and HANKE, Kirsten, additional
- Published
- 2021
- Full Text
- View/download PDF
42. Additional file 1 of Barriers to using HIV pre-exposure prophylaxis (PrEP) and sexual behaviour after stopping PrEP: a cross-sectional study in Germany
- Author
-
Koppe, Uwe, Marcus, Ulrich, Albrecht, Stefan, Jansen, Klaus, Jessen, Heiko, Gunsenheimer-Bartmeyer, Barbara, and Bremer, Viviane
- Subjects
Data_FILES - Abstract
Additional file 1.
- Published
- 2021
- Full Text
- View/download PDF
43. Treatment modifcation after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005-2017 (vol 48, pg 723, 2020)
- Author
-
Stecher, Melanie, Schommers, Philipp, Kollan, Christian, Stoll, Matthias, Kuhlendahl, Frieder, Stellbrink, Hans-Juergen, Wasmuth, Jan-Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Schuermann, Dirk, Degen, Olaf, Horst, Heinz-August, Hoffmann, Christian, Jensen, Bjoern, Schwarze-Zander, Carolynne, Platten, Martin, Faetkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, Vehreschild, Joerg Janne, Stecher, Melanie, Schommers, Philipp, Kollan, Christian, Stoll, Matthias, Kuhlendahl, Frieder, Stellbrink, Hans-Juergen, Wasmuth, Jan-Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Schuermann, Dirk, Degen, Olaf, Horst, Heinz-August, Hoffmann, Christian, Jensen, Bjoern, Schwarze-Zander, Carolynne, Platten, Martin, Faetkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, and Vehreschild, Joerg Janne
- Published
- 2021
44. Correction to: Treatment modifcation after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005–2017
- Author
-
ClinSurv Study Group, Stecher, Melanie, Schommers, Philipp Frederik, Kollan, Christian, Stoll, Matthias, Kuhlendahl, Frieder-Johan, Stellbrink, Hans‑Jürgen, Wasmuth, Jan‑Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Schürmann, Dirk, Degen, Olaf, Horst, Heinz August, Hoffmann, Christian, Jensen, Björn-Erik Ole, Schwarze-Zander, Carolynne, Platten, Martin, Fätkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, Vehreschild, Jörg Janne, ClinSurv Study Group, Stecher, Melanie, Schommers, Philipp Frederik, Kollan, Christian, Stoll, Matthias, Kuhlendahl, Frieder-Johan, Stellbrink, Hans‑Jürgen, Wasmuth, Jan‑Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Schürmann, Dirk, Degen, Olaf, Horst, Heinz August, Hoffmann, Christian, Jensen, Björn-Erik Ole, Schwarze-Zander, Carolynne, Platten, Martin, Fätkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, and Vehreschild, Jörg Janne
- Abstract
Correction to: Infection (2020) 48:723–733 https://doi.org/10.1007/s15010-020-01469-6. The original version of this article unfortunately contained a mistake. In this article the authors Dirk Schürmann at affiliation Charité, University Medicine, Berlin, Olaf Degen at affiliation University Clinic Hamburg Eppendorf, Hamburg and Heinz-August Horst at affiliation University Hospital Schleswig–Holstein, Kiel, Germany were missing from the author list. The original article has been corrected.
- Published
- 2021
45. Schätzung der Zahl der HIV-Neuinfektionen im Jahr 2019 und der Gesamtzahl von Menschen, die Ende 2019 mit HIV in Deutschland leben
- Author
-
an der Heiden, Matthias, Marcus, Ulrich, Kollan, Christian, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, and Bremer, Viviane
- Subjects
Präexpositionsprophylaxe ,Risikogruppen ,HIV/AIDS ,Modellierung ,antiretrovirale Therapie ,ddc:610 ,610 Medizin und Gesundheit - Abstract
Die Zahl der HIV-Neuinfektionen in Deutschland und bei Menschen deutscher Herkunft, die sich im Ausland mit HIV infiziert haben, wird 2019 auf 2.600 geschätzt und steigt damit im Vergleich zum Vorjahr leicht an. Die Zahl der Menschen mit HIV, deren Infektion noch nicht diagnostiziert wurde, liegt seit 2008 relativ konstant bei etwa 10.800. Wie das Epidemiologische Bulletin 48/2020 berichtet ist dagegen der Anteil der Personen, die mit einer HIV-Infektion diagnostiziert wurden und eine antiretrovirale Therapie erhalten, von etwa 80% im Jahr 2006 auf 97% im Jahr 2019 angestiegen. Der Anteil erfolgreicher Therapien erhöhte sich nochmals leicht und liegt jetzt bei etwa 96%.
- Published
- 2020
- Full Text
- View/download PDF
46. Progress towards the 90-90-90 HIV targets in 11 EU countries
- Author
-
Vourli, Georgia, Noori, Teymur, Porter, Kholoud, Begovac, Josip, Delpech, Valerie, Girardi, Enrico, Gunsenheimer-Bartmeyer, Barbara, Hernando, Victoria, Obel, Niels, Van Sighem, Ard, Sönnerborg, Anders, Supervie, Virginie, Zangerle, Robert, and Touloumi, Giota
- Subjects
Antiretroviral treatment (ART) ,HIV ,care ,EU - Abstract
Despite the availability of highly effective antiretroviral treatment (ART), delayed diagnosis and ART initiation, and poor retention in care remain barriers to reducing HIV incidence. We aimed to estimate progress towards the UNAIDS 90- 90-90 targets by constructing the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. Using surveillance and cohort data from Austria, Croatia, Denmark, Germany, Greece, France, Italy, the Netherlands, Spain, Sweden and the United Kingdom, a CoC was constructed with four stages: i) number of people living with HIV (PLHIV) ; ii) proportion of PLHIV ever diagnosed ; iii) proportion of diagnosed who initiated ART ; iv) proportion of treated who achieved viral suppression (≤200 copies/mL) at their last visit (July 2015- December 2016). The 11 countries represent 73% of EU population and 85% of PLHIV in the region. The estimated number of PLHIV in the participating countries at the end of 2016 was 702, 848, corresponding to 0.19% adult prevalence. Overall, we estimated that 87% of PLHIV were diagnosed ; 92% of those diagnosed had initiated ART ; and 91% of those on ART were virally suppressed. Therefore, among all PLHIV 73% were virally suppressed. The corresponding figures for men having sex with men (MSM) were: 86%, 93%, 93% (and among all PLHIV 74%) ; for people who inject drugs (PWID): 91%, 88%, 84% (67%) ; for heterosexuals: 86%, 92%, 91% (72%) ; for men: 87%, 92%, 91% (73%) and for women: 89%, 92%, 89% (73%). Substantial variation across countries was observed. The EU is near to reaching the 90-90-90 UNAIDS targets, and achieved the UNAIDS final target of 73% of all PLHIV with viral suppression. This finding represents a significant progress compared to 2013, where 60% of all PLHIV were virally suppressed. However, differences between countries and key populations persisted in 2016. To improve outcomes along the CoCs, annual numbers of newly- acquired HIV infections and time intervals spent between stages need to be reduced. Furthermore, strengthening of testing programs and stronger treatment and adherence support, along with HIV prevention measures, are needed to achieve HIV epidemic control and, ultimately, AIDS elimination by 2030.
- Published
- 2020
47. Treatment modification after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005-2017
- Author
-
Stecher, Melanie, Schommers, Philipp, Kollan, Christian, Stoll, Matthias, Kuhlendahr, Frieder, Stellbrink, Hans-Juergen, Wasmuth, Jan-Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Hoffmann, Christian, Jensen, Bjoern, Schwarze-Zander, Carolynne, Platten, Martin, Faetkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, Vehreschild, Joerg Janne, Stecher, Melanie, Schommers, Philipp, Kollan, Christian, Stoll, Matthias, Kuhlendahr, Frieder, Stellbrink, Hans-Juergen, Wasmuth, Jan-Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Hoffmann, Christian, Jensen, Bjoern, Schwarze-Zander, Carolynne, Platten, Martin, Faetkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, and Vehreschild, Joerg Janne
- Abstract
Objective Combination antiretroviral therapy (cART) has markedly increased survival and quality of life in people living with HIV. With the advent of new treatment options, including single-tablet regimens, durability and efficacy of first-line cART regimens are evolving. Methods We analyzed data from the prospective multicenter German Clinical Surveillance of HIV Disease (ClinSurv) cohort of the Robert-Koch Institute. Kaplan-Meier and Cox proportional hazards models were run to examine the factors associated with treatment modification. Recovery after treatment initiation was analyzed comparing pre-cART viral load and CD4+ T-cell counts with follow-up data. Results We included 8788 patients who initiated cART between 2005 and 2017. The sample population was predominantly male (n = 7040; 80.1%), of whom 4470 (63.5%) were reporting sex with men as the transmission risk factor. Overall, 4210 (47.9%) patients modified their first-line cART after a median time of 63 months (IQR 59-66). Regimens containing integrase strand transfer inhibitors (INSTI) were associated with significantly lower rates of treatment modification (adjusted hazard ratio 0.44; 95% CI 0.39-0.50) compared to protease inhibitor (PI)-based regimens. We found a decreased durability of first-line cART significantly associated with being female, a low CD4+ T-cell count, cART initiation in the later period (2011-2017), being on a multi-tablet regimen (MTR). Conclusions Drug class and MTRs are significantly associated with treatment modification. INSTI-based regimens showed to be superior compared to PI-based regimens in terms of durability.
- Published
- 2020
48. Human immunodeficiency virus continuum of care in 11 european union countries at the end of 2016 overall and by key population:Have we made progress?
- Author
-
Vourli, Georgia, Noori, Teymur, Pharris, Anastasia, Porter, Kholoud, Axelsson, Maria, Begovac, Josip, Cazein, Francoise, Costagliola, Dominique, Cowan, Susan, Croxford, Sara, Monforte, Antonella d.Arminio, Delpech, Valerie, Díaz, Asunción, Girardi, Enrico, Gunsenheimer-Bartmeyer, Barbara, Hernando, Victoria, Leierer, Gisela, Lot, Florence, Nunez, Olivier, Obel, Niels, Op de Coul, Eline, Paraskeva, Dimitra, Patrinos, Stavros, Reiss, Peter, Schmid, Daniela, Sonnerborg, Anders, Suligoi, Barbara, Supervie, Virginie, van Sighem, Ard, Zangerle, Robert, Touloumi, Giota, Egle, Alexander, Kanatschnig, Manfred, Öllinger, Angela, Rieger, Armin, Schmied, Brigitte, Wallner, Elmar, Dewasurendra, Diyani, Gisinger, Martin, Kitchen, Maria, Plattner, Alexander, Rieser, Elisabeth, Sarcletti, Mario, Greil, Richard, Schachner, Michaela, Skocic, Matthias, Müller, Monika, Kronborg, G., Kvinesdal, B., Honoré, P., Vourli, Georgia, Noori, Teymur, Pharris, Anastasia, Porter, Kholoud, Axelsson, Maria, Begovac, Josip, Cazein, Francoise, Costagliola, Dominique, Cowan, Susan, Croxford, Sara, Monforte, Antonella d.Arminio, Delpech, Valerie, Díaz, Asunción, Girardi, Enrico, Gunsenheimer-Bartmeyer, Barbara, Hernando, Victoria, Leierer, Gisela, Lot, Florence, Nunez, Olivier, Obel, Niels, Op de Coul, Eline, Paraskeva, Dimitra, Patrinos, Stavros, Reiss, Peter, Schmid, Daniela, Sonnerborg, Anders, Suligoi, Barbara, Supervie, Virginie, van Sighem, Ard, Zangerle, Robert, Touloumi, Giota, Egle, Alexander, Kanatschnig, Manfred, Öllinger, Angela, Rieger, Armin, Schmied, Brigitte, Wallner, Elmar, Dewasurendra, Diyani, Gisinger, Martin, Kitchen, Maria, Plattner, Alexander, Rieser, Elisabeth, Sarcletti, Mario, Greil, Richard, Schachner, Michaela, Skocic, Matthias, Müller, Monika, Kronborg, G., Kvinesdal, B., and Honoré, P.
- Abstract
Background. High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) transmission and related mortality; however, gaps in care exist. We aimed to construct the continuum of HIV care (CoC) in 2016 in 11 European Union (EU) countries, overall and by key population and sex. To estimate progress toward the Joint United Nations Programme on HIV/AIDS (UNAIDS) 90-90-90 target, we compared 2016 to 2013 estimates for the same countries, representing 73% of the population in the region. Methods. A CoC with the following 4 stages was constructed: number of people living with HIV (PLHIV); proportion of PLHIV diagnosed; proportion of those diagnosed who ever initiated ART; and proportion of those ever treated who achieved viral suppression at their last visit. Results. We estimated that 87% of PLHIV were diagnosed; 92% of those diagnosed had ever initiated ART; and 91% of those ever on ART, or 73% of all PLHIV, were virally suppressed. Corresponding figures for men having sex with men were: 86%, 93%, 93%, 74%; for people who inject drugs: 94%, 88%, 85%, 70%; and for heterosexuals: 86%, 92%, 91%, 72%. The proportion suppressed of all PLHIV ranged from 59% to 86% across countries. Conclusions. The EU is close to the 90-90-90 target and achieved the UNAIDS target of 73% of all PLHIV virally suppressed, significant progress since 2013 when 60% of all PLHIV were virally suppressed. Strengthening of testing programs and treatment support, along with prevention interventions, are needed to achieve HIV epidemic control.
- Published
- 2020
49. Treatment modification after starting cART in people living with HIV: retrospective analysis of the German ClinSurv HIV Cohort 2005–2017
- Author
-
ClinSurv Study Group, Stecher, Melanie, Schommers, Philipp, Kollan, Christian, Stoll, Matthias, Kuhlendahl, Frieder, Stellbrink, Hans‑Jürgen, Wasmuth, Jan‑Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Hofmann, Christian, Jensen, Björn, Schwarze‑Zander, Carolynne, Platten, Martin, Fätkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, Vehreschild, Jörg Janne, ClinSurv Study Group, Stecher, Melanie, Schommers, Philipp, Kollan, Christian, Stoll, Matthias, Kuhlendahl, Frieder, Stellbrink, Hans‑Jürgen, Wasmuth, Jan‑Christian, Stephan, Christoph, Hamacher, Laura, Lehmann, Clara, Boesecke, Christoph, Bogner, Johannes, Esser, Stefan, Fritzsche, Carlos, Haberl, Annette, Hofmann, Christian, Jensen, Björn, Schwarze‑Zander, Carolynne, Platten, Martin, Fätkenheuer, Gerd, Schmidt, Daniel, Gunsenheimer-Bartmeyer, Barbara, and Vehreschild, Jörg Janne
- Abstract
Objective: Combination antiretroviral therapy (cART) has markedly increased survival and quality of life in people living with HIV. With the advent of new treatment options, including single-tablet regimens, durability and efficacy of first-line cART regimens are evolving. Methods: We analyzed data from the prospective multicenter German Clinical Surveillance of HIV Disease (ClinSurv) cohort of the Robert-Koch Institute. Kaplan–Meier and Cox proportional hazards models were run to examine the factors associated with treatment modification. Recovery after treatment initiation was analyzed comparing pre-cART viral load and CD4+ T-cell counts with follow-up data. Results: We included 8788 patients who initiated cART between 2005 and 2017. The sample population was predominantly male (n = 7040; 80.1%), of whom 4470 (63.5%) were reporting sex with men as the transmission risk factor. Overall, 4210 (47.9%) patients modified their first-line cART after a median time of 63 months (IQR 59–66). Regimens containing integrase strand transfer inhibitors (INSTI) were associated with significantly lower rates of treatment modification (adjusted hazard ratio 0.44; 95% CI 0.39–0.50) compared to protease inhibitor (PI)-based regimens. We found a decreased durability of first-line cART significantly associated with being female, a low CD4+ T-cell count, cART initiation in the later period (2011–2017), being on a multi-tablet regimen (MTR). Conclusions: Drug class and MTRs are significantly associated with treatment modification. INSTI-based regimens showed to be superior compared to PI-based regimens in terms of durability.
- Published
- 2020
50. Decreasing prevalence and stagnating incidence of Hepatitis C‐co‐infection among a cohort of HIV‐1‐positive patients, with a majority of men who have sex with men, in Germany, 1996–2019.
- Author
-
Krings, Amrei, Schmidt, Daniel, Meixenberger, Karolin, Bannert, Norbert, Münstermann, Dieter, Tiemann, Carsten, Kollan, Christian, and Gunsenheimer‐Bartmeyer, Barbara
- Subjects
MEN who have sex with men ,GONORRHEA ,AIDS ,HEPATITIS C virus ,VIRAL hepatitis ,HEPATITIS - Abstract
Co‐infection with Hepatitis C virus (HCV) among HIV‐positive patients leads to accelerated progression of liver disease and AIDS. Due to increased HCV prevalence and incidence, co‐infection requires monitoring trends among HIV‐positive individuals. This will help target prevention strategies and support to reach the global goals of eliminating viral hepatitis as a public health threat. In this analysis HCV prevalence and incidence were determined for the years 1996–2019 from yearly blood samples and questionnaire details among HIV‐1‐positive patients, with a majority of men who have sex with men, belonging to a nationwide, multicentre observational, prospective cohort study. The results show that HCV prevalence for acute/chronic and resolved infection increased until 2014 to 12%. Since then, prevalence of acute/chronic HCV infection rapidly decreased and prevalence of resolved infections showed a steady increase. HCV incidence was highest in 2010 and lowest in 2017; however, no significant change in HCV incidence could be seen over the years. Therefore, the introduction of directly‐acting antiviral agents for HCV treatment notably decreased prevalence and potentially incidence of acute/chronic HCV infection. Nevertheless, prevalence and incidence of HCV among these HIV‐1‐positive study participants remain high compared with the general population and justify the need for continuous HCV prevention and treatment efforts among HIV‐positive individuals. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.