4,064 results on '"Gunter, Marc"'
Search Results
2. Prognostic role of pre-diagnostic circulating inflammatory biomarkers in breast cancer survival: evidence from the EPIC cohort study
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Castro-Espin, Carlota, Cairat, Manon, Navionis, Anne-Sophie, Dahm, Christina C., Antoniussen, Christian S., Tjønneland, Anne, Mellemkjær, Lene, Mancini, Francesca Romana, Hajji-Louati, Mariem, Severi, Gianluca, Le Cornet, Charlotte, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Agnoli, Claudia, Sacerdote, Carlotta, Crous-Bou, Marta, Sánchez, Maria-Jose, Amiano, Pilar, Chirlaque, María-Dolores, Guevara, Marcela, Smith-Byrne, Karl, Heath, Alicia K., Christakoudi, Sofia, Gunter, Marc J., Rinaldi, Sabina, Agudo, Antonio, and Dossus, Laure
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- 2024
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3. Association of metabolic obesity phenotypes with risk of overall and site-specific cancers: a systematic review and meta-analysis of cohort studies
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Mahamat-saleh, Yahya, Aune, Dagfinn, Freisling, Heinz, Hardikar, Sheetal, Jaafar, Rola, Rinaldi, Sabina, Gunter, Marc J., and Dossus, Laure
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- 2024
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4. Allometric fat mass index and alanine aminotransferase attenuate the associations of platelet parameters with lung cancer risk
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Christakoudi, Sofia, Tsilidis, Konstantinos K., Gunter, Marc J., and Riboli, Elio
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- 2024
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5. Degree of food processing and breast cancer risk: a prospective study in 9 European countries
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Cairat, Manon, Yammine, Sahar, Fiolet, Thibault, Fournier, Agnès, Boutron-Ruault, Marie-Christine, Laouali, Nasser, Mancini, Francesca Romana, Severi, Gianluca, Berstein, Fernanda Morales, Rauber, Fernanda, Levy, Renata Bertazzi, Skeie, Guri, Borch, Kristin Benjaminsen, Tjønneland, Anne, Mellemkjær, Lene, Borné, Yan, Rosendahl, Ann H., Masala, Giovanna, Giraudo, Maria Teresa, de Magistris, Maria Santucci, Katzke, Verena, Bajracharya, Rashmita, Santiuste, Carmen, Amiano, Pilar, Bodén, Stina, Castro-Espin, Carlota, Sánchez, Maria-Jose, Touvier, Mathilde, Deschasaux-Tanguy, Mélanie, Srour, Bernard, Schulze, Matthias B., Guevara, Marcela, Kliemann, Nathalie, Lopez, Jessica Blanco, Al Nahas, Aline, Chang, Kiara, Vamos, Eszter P., Millett, Christopher, Riboli, Elio, Heath, Alicia K., Biessy, Carine, Viallon, Vivian, Casagrande, Corinne, Nicolas, Genevieve, Gunter, Marc J., and Huybrechts, Inge
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- 2024
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6. Calcium intake and genetic variants in the calcium sensing receptor in relation to colorectal cancer mortality: an international consortium study of 18,952 patients
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Wesselink, Evertine, Gauderman, William, Berndt, Sonja I., Brenner, Hermann, Buchanan, Daniel D., Campbell, Peter T., Chan, Andrew T., Chang-Claude, Jenny, Cotterchoi, Michelle, Gunter, Marc J., Hoffmeister, Michael, Joshi, Amit D., Newton, Christina C., Pai, Rish K., Pellatt, Andrew J., Phipps, Amanda I., Song, Mingyang, Um, Caroline Y., van Guelpen, Bethany, White, Emily, Peters, Ulrike, and van Duijnhoven, Fränzel J. B.
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- 2024
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7. Association of body shape phenotypes and body fat distribution indexes with inflammatory biomarkers in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank
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González-Gil, Esther M., Peruchet-Noray, Laia, Sedlmeier, Anja M., Christakoudi, Sofia, Biessy, Carine, Navionis, Anne-Sophie, Mahamat-Saleh, Yahya, Jaafar, Rola F., Baurecht, Hansjörg, Guevara, Marcela, Etxezarreta, Pilar Amiano, Verschuren, W. M. Monique, Boer, Jolanda M. A., Olsen, Anja, Tjønneland, Anne, Simeon, Vittorio, Castro-Espin, Carlota, Aune, Dagfinn, Heath, Alicia K., Gunter, Marc, Colorado-Yohar, Sandra M., Zilhão, Nuno R., Dahm, Christina C., Llanaj, Erand, Schulze, Matthias B., Petrova, Dafina, Sieri, Sabina, Ricceri, Fulvio, Masala, Giovanna, Key, Tim, Viallon, Vivian, Rinaldi, Sabina, Freisling, Heinz, and Dossus, Laure
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- 2024
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8. On the use of the healthy lifestyle index to investigate specific disease outcomes
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Viallon, Vivian, Freisling, Heinz, Matta, Komodo, Nannsen, Anne Østergaard, Dahm, Christina C., Tjønneland, Anne, Eriksen, Anne Kirstine, Kaaks, Rudolf, Katzke, Verena A., Schulze, Matthias B., Masala, Giovanna, Tagliabue, Giovanna, Simeon, Vittorio, Tumino, Rosario, Milani, Lorenzo, Derksen, Jeroen W. G., van der Schouw, Yvonne T., Nøst, Therese Haugdahl, Borch, Kristin Benjaminsen, Sandanger, Torkjel M., Quirós, J. Ramón, Rodriguez-Barranco, Miguel, Bonet, Catalina, Aizpurua-Atxega, Amaia, Cirera, Lluís, Guevara, Marcela, Sundström, Björn, Winkvist, Anna, Heath, Alicia K., Gunter, Marc J., Weiderpass, Elisabete, Johansson, Mattias, and Ferrari, Pietro
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- 2024
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9. Circulating free insulin-like growth factor-I and prostate cancer: a case-control study nested in the European prospective investigation into cancer and nutrition
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Cheng, Tuck Seng, Noor, Urwah, Watts, Eleanor, Pollak, Michael, Wang, Ye, McKay, James, Atkins, Joshua, Masala, Giovanna, Sánchez, Maria-Jose, Agudo, Antonio, Castilla, Jesús, Aune, Dagfinn, Colorado-Yohar, Sandra M., Manfredi, Luca, Gunter, Marc J., Pala, Valeria, Josefsson, Andreas, Key, Timothy J., Smith-Byrne, Karl, and Travis, Ruth C.
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- 2024
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10. Hepatic steatosis, metabolic dysfunction and risk of mortality: findings from a multinational prospective cohort study
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Mayén, Ana-Lucia, Sabra, Mirna, Aglago, Elom K., Perlemuter, Gabriel, Voican, Cosmin, Ramos, Ines, Debras, Charlotte, Blanco, Jessica, Viallon, Vivian, Ferrari, Pietro, Olsen, Anja, Tjønneland, Anne, Langmann, Fie, Dahm, Christina C., Rothwell, Joseph, Laouali, Nasser, Marques, Chloé, Schulze, Matthias B., Katzke, Verena, Kaaks, Rudolf, Palli, Domenico, Macciotta, Alessandra, Panico, Salvatore, Tumino, Rosario, Agnoli, Claudia, Farràs, Marta, Molina-Montes, Esther, Amiano, Pilar, Chirlaque, María-Dolores, Castilla, Jesús, Werner, Mårten, Bodén, Stina, Heath, Alicia K., Tsilidis, Kostas, Aune, Dagfinn, Weiderpass, Elisabete, Freisling, Heinz, Gunter, Marc J., and Jenab, Mazda
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- 2024
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11. Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort
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Matta, Komodo, Viallon, Vivian, Botteri, Edoardo, Peveri, Giulia, Dahm, Christina, Nannsen, Anne Østergaard, Olsen, Anja, Tjønneland, Anne, Elbaz, Alexis, Artaud, Fanny, Marques, Chloé, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Llanaj, Erand, Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Tumino, Rosario, Ricceri, Fulvio, Derksen, Jeroen W. G., Nøst, Therese Haugdahl, Sandanger, Torkjel M., Borch, Kristin Benjaminsen, Quirós, J. Ramón, Castro-Espin, Carlota, Sánchez, Maria-José, Atxega, Amaia Aizpurua, Cirera, Lluís, Guevara, Marcela, Manjer, Jonas, Tin Tin, Sandar, Heath, Alicia, Touvier, Mathilde, Goldberg, Marcel, Weiderpass, Elisabete, Gunter, Marc J., Freisling, Heinz, Riboli, Elio, and Ferrari, Pietro
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- 2024
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12. Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
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Chen, Zhishan, Guo, Xingyi, Tao, Ran, Huyghe, Jeroen R., Law, Philip J., Fernandez-Rozadilla, Ceres, Ping, Jie, Jia, Guochong, Long, Jirong, Li, Chao, Shen, Quanhu, Xie, Yuhan, Timofeeva, Maria N., Thomas, Minta, Schmit, Stephanie L., Díez-Obrero, Virginia, Devall, Matthew, Moratalla-Navarro, Ferran, Fernandez-Tajes, Juan, Palles, Claire, Sherwood, Kitty, Briggs, Sarah E. W., Svinti, Victoria, Donnelly, Kevin, Farrington, Susan M., Blackmur, James, Vaughan-Shaw, Peter G., Shu, Xiao-Ou, Lu, Yingchang, Broderick, Peter, Studd, James, Harrison, Tabitha A., Conti, David V., Schumacher, Fredrick R., Melas, Marilena, Rennert, Gad, Obón-Santacana, Mireia, Martín-Sánchez, Vicente, Oh, Jae Hwan, Kim, Jeongseon, Jee, Sun Ha, Jung, Keum Ji, Kweon, Sun-Seog, Shin, Min-Ho, Shin, Aesun, Ahn, Yoon-Ok, Kim, Dong-Hyun, Oze, Isao, Wen, Wanqing, Matsuo, Keitaro, Matsuda, Koichi, Tanikawa, Chizu, Ren, Zefang, Gao, Yu-Tang, Jia, Wei-Hua, Hopper, John L., Jenkins, Mark A., Win, Aung Ko, Pai, Rish K., Figueiredo, Jane C., Haile, Robert W., Gallinger, Steven, Woods, Michael O., Newcomb, Polly A., Duggan, David, Cheadle, Jeremy P., Kaplan, Richard, Kerr, Rachel, Kerr, David, Kirac, Iva, Böhm, Jan, Mecklin, Jukka-Pekka, Jousilahti, Pekka, Knekt, Paul, Aaltonen, Lauri A., Rissanen, Harri, Pukkala, Eero, Eriksson, Johan G., Cajuso, Tatiana, Hänninen, Ulrika, Kondelin, Johanna, Palin, Kimmo, Tanskanen, Tomas, Renkonen-Sinisalo, Laura, Männistö, Satu, Albanes, Demetrius, Weinstein, Stephanie J., Ruiz-Narvaez, Edward, Palmer, Julie R., Buchanan, Daniel D., Platz, Elizabeth A., Visvanathan, Kala, Ulrich, Cornelia M., Siegel, Erin, Brezina, Stefanie, Gsur, Andrea, Campbell, Peter T., Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Slattery, Martha L., Potter, John D., Tsilidis, Kostas K., Schulze, Matthias B., Gunter, Marc J., Murphy, Neil, Castells, Antoni, Castellví-Bel, Sergi, Moreira, Leticia, Arndt, Volker, Shcherbina, Anna, Bishop, D. Timothy, Giles, Graham G., Southey, Melissa C., Idos, Gregory E., McDonnell, Kevin J., Abu-Ful, Zomoroda, Greenson, Joel K., Shulman, Katerina, Lejbkowicz, Flavio, Offit, Kenneth, Su, Yu-Ru, Steinfelder, Robert, Keku, Temitope O., van Guelpen, Bethany, Hudson, Thomas J., Hampel, Heather, Pearlman, Rachel, Berndt, Sonja I., Hayes, Richard B., Martinez, Marie Elena, Thomas, Sushma S., Pharoah, Paul D. P., Larsson, Susanna C., Yen, Yun, Lenz, Heinz-Josef, White, Emily, Li, Li, Doheny, Kimberly F., Pugh, Elizabeth, Shelford, Tameka, Chan, Andrew T., Cruz-Correa, Marcia, Lindblom, Annika, Hunter, David J., Joshi, Amit D., Schafmayer, Clemens, Scacheri, Peter C., Kundaje, Anshul, Schoen, Robert E., Hampe, Jochen, Stadler, Zsofia K., Vodicka, Pavel, Vodickova, Ludmila, Vymetalkova, Veronika, Edlund, Christopher K., Gauderman, W. James, Shibata, David, Toland, Amanda, Markowitz, Sanford, Kim, Andre, Chanock, Stephen J., van Duijnhoven, Franzel, Feskens, Edith J. M., Sakoda, Lori C., Gago-Dominguez, Manuela, Wolk, Alicja, Pardini, Barbara, FitzGerald, Liesel M., Lee, Soo Chin, Ogino, Shuji, Bien, Stephanie A., Kooperberg, Charles, Li, Christopher I., Lin, Yi, Prentice, Ross, Qu, Conghui, Bézieau, Stéphane, Yamaji, Taiki, Sawada, Norie, Iwasaki, Motoki, Le Marchand, Loic, Wu, Anna H., Qu, Chenxu, McNeil, Caroline E., Coetzee, Gerhard, Hayward, Caroline, Deary, Ian J., Harris, Sarah E., Theodoratou, Evropi, Reid, Stuart, Walker, Marion, Ooi, Li Yin, Lau, Ken S., Zhao, Hongyu, Hsu, Li, Cai, Qiuyin, Dunlop, Malcolm G., Gruber, Stephen B., Houlston, Richard S., Moreno, Victor, Casey, Graham, Peters, Ulrike, Tomlinson, Ian, and Zheng, Wei
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- 2024
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13. Dietary patterns, untargeted metabolite profiles and their association with colorectal cancer risk
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Bodén, Stina, Zheng, Rui, Ribbenstedt, Anton, Landberg, Rikard, Harlid, Sophia, Vidman, Linda, Gunter, Marc J., Winkvist, Anna, Johansson, Ingegerd, Van Guelpen, Bethany, and Brunius, Carl
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- 2024
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14. Genome-wide interaction analysis of folate for colorectal cancer risk.
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Bouras, Emmanouil, Kim, Andre, Lin, Yi, Morrison, John, Du, Mengmeng, Albanes, Demetrius, Barry, Elizabeth, Baurley, James, Berndt, Sonja, Bien, Stephanie, Bishop, Timothy, Brenner, Hermann, Budiarto, Arif, Burnett-Hartman, Andrea, Campbell, Peter, Carreras-Torres, Robert, Casey, Graham, Cenggoro, Tjeng, Chan, Andrew, Chang-Claude, Jenny, Conti, David, Cotterchio, Michelle, Devall, Matthew, Diez-Obrero, Virginia, Dimou, Niki, Drew, David, Figueiredo, Jane, Giles, Graham, Gruber, Stephen, Gunter, Marc, Harrison, Tabitha, Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen, Joshi, Amit, Kawaguchi, Eric, Keku, Temitope, Kundaje, Anshul, Le Marchand, Loic, Lewinger, Juan, Li, Li, Lynch, Brigid, Mahesworo, Bharuno, Männistö, Satu, Moreno, Victor, Murphy, Neil, Newcomb, Polly, Obón-Santacana, Mireia, Ose, Jennifer, Palmer, Julie, Papadimitriou, Nikos, Pardamean, Bens, Pellatt, Andrew, Peoples, Anita, Platz, Elizabeth, Potter, John, Qi, Lihong, Qu, Conghui, Rennert, Gad, Ruiz-Narvaez, Edward, Sakoda, Lori, Schmit, Stephanie, Shcherbina, Anna, Stern, Mariana, Su, Yu-Ru, Tangen, Catherine, Thomas, Duncan, Tian, Yu, Um, Caroline, van Duijnhoven, Franzel, Van Guelpen, Bethany, Visvanathan, Kala, Wang, Jun, White, Emily, Wolk, Alicja, Woods, Michael, Ulrich, Cornelia, Hsu, Li, Gauderman, W, Peters, Ulrike, and Tsilidis, Konstantinos
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CRC ,European ,GWIS ,SYN2 ,TIMP4 ,colorectal cancer ,folate ,folic acid ,genome-wide ,interaction ,synapsin ,tissue inhibitor of metalloproteinase 4 ,Humans ,Folic Acid ,Risk Factors ,Colorectal Neoplasms ,Case-Control Studies ,Dietary Supplements - Abstract
BACKGROUND: Epidemiological and experimental evidence suggests that higher folate intake is associated with decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation that may have a direct or indirect impact on folate metabolism can provide insights into folates role in CRC. OBJECTIVES: Our aim was to perform a genome-wide interaction analysis to identify genetic variants that may modify the association of folate on CRC risk. METHODS: We applied traditional case-control logistic regression, joint 3-degree of freedom, and a 2-step weighted hypothesis approach to test the interactions of common variants (allele frequency >1%) across the genome and dietary folate, folic acid supplement use, and total folate in relation to risk of CRC in 30,550 cases and 42,336 controls from 51 studies from 3 genetic consortia (CCFR, CORECT, GECCO). RESULTS: Inverse associations of dietary, total folate, and folic acid supplement with CRC were found (odds ratio [OR]: 0.93; 95% confidence interval [CI]: 0.90, 0.96; and 0.91; 95% CI: 0.89, 0.94 per quartile higher intake, and 0.82 (95% CI: 0.78, 0.88) for users compared with nonusers, respectively). Interactions (P-interaction < 5×10-8) of folic acid supplement and variants in the 3p25.2 locus (in the region of Synapsin II [SYN2]/tissue inhibitor of metalloproteinase 4 [TIMP4]) were found using traditional interaction analysis, with variant rs150924902 (located upstream to SYN2) showing the strongest interaction. In stratified analyses by rs150924902 genotypes, folate supplementation was associated with decreased CRC risk among those carrying the TT genotype (OR: 0.82; 95% CI: 0.79, 0.86) but increased CRC risk among those carrying the TA genotype (OR: 1.63; 95% CI: 1.29, 2.05), suggesting a qualitative interaction (P-interaction = 1.4×10-8). No interactions were observed for dietary and total folate. CONCLUSIONS: Variation in 3p25.2 locus may modify the association of folate supplement with CRC risk. Experimental studies and studies incorporating other relevant omics data are warranted to validate this finding.
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- 2023
15. Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk
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Tian, Yu, Lin, Yi, Qu, Conghui, Arndt, Volker, Baurley, James W., Berndt, Sonja I., Bien, Stephanie A., Bishop, D. Timothy, Brenner, Hermann, Buchanan, Daniel D., Budiarto, Arif, Campbell, Peter T., Carreras-Torres, Robert, Casey, Graham, Chan, Andrew T., Chen, Rui, Chen, Xuechen, Conti, David V., Díez-Obrero, Virginia, Dimou, Niki, Drew, David A., Figueiredo, Jane C., Gallinger, Steven, Giles, Graham G., Gruber, Stephen B., Gunter, Marc J., Harlid, Sophia, Harrison, Tabitha A., Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen R., Jenkins, Mark A., Jordahl, Kristina M., Joshi, Amit D., Keku, Temitope O., Kawaguchi, Eric, Kim, Andre E., Kundaje, Anshul, Larsson, Susanna C., Marchand, Loic Le, Lewinger, Juan Pablo, Li, Li, Moreno, Victor, Morrison, John, Murphy, Neil, Nan, Hongmei, Nassir, Rami, Newcomb, Polly A., Obón-Santacana, Mireia, Ogino, Shuji, Ose, Jennifer, Pardamean, Bens, Pellatt, Andrew J., Peoples, Anita R., Platz, Elizabeth A., Potter, John D., Prentice, Ross L., Rennert, Gad, Ruiz-Narvaez, Edward A., Sakoda, Lori C., Schoen, Robert E., Shcherbina, Anna, Stern, Mariana C., Su, Yu-Ru, Thibodeau, Stephen N., Thomas, Duncan C., Tsilidis, Konstantinos K., van Duijnhoven, Franzel J. B., Van Guelpen, Bethany, Visvanathan, Kala, White, Emily, Wolk, Alicja, Woods, Michael O., Wu, Anna H., Peters, Ulrike, Gauderman, W. James, Hsu, Li, and Chang-Claude, Jenny
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- 2024
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16. Sex-steroid hormones and risk of postmenopausal estrogen receptor-positive breast cancer: a case–cohort analysis
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Albers, Frances E. M., Lou, Makayla W. C., Dashti, S. Ghazaleh, Swain, Christopher T. V., Rinaldi, Sabina, Viallon, Vivian, Karahalios, Amalia, Brown, Kristy A., Gunter, Marc J., Milne, Roger L., English, Dallas R., and Lynch, Brigid M.
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- 2024
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17. Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis
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Rontogianni, Marina O., Bouras, Emmanouil, Aglago, Elom Kouassivi, Freisling, Heinz, Murphy, Neil, Cotterchio, Michelle, Hampe, Jochen, Lindblom, Annika, Pai, Rish K., Pharoah, Paul D. P., Phipps, Amanda I., van Duijnhoven, Franzel J. B., Visvanathan, Kala, van Guelpen, Bethany, Li, Christopher I., Brenner, Hermann, Pellatt, Andrew J., Ogino, Shuji, Gunter, Marc J., Peters, Ulrike, Christakoudi, Sofia, and Tsilidis, Konstantinos K.
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- 2024
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18. Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions
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Lindström, Sara, Wang, Lu, Feng, Helian, Majumdar, Arunabha, Huo, Sijia, Macdonald, James, Harrison, Tabitha, Turman, Constance, Chen, Hongjie, Mancuso, Nicholas, Bammler, Theo, Consortium, Breast Cancer Association, Gallinger, Steve, Gruber, Stephen B, Gunter, Marc J, Le Marchand, Loic, Moreno, Victor, Offit, Kenneth, Study, Genetics And Epidemiology Of Colorectal Cancer Consortium Colorectal Transdisciplinary Study Colon Cancer Family Registry, De Vivo, Immaculata, O’Mara, Tracy A, Spurdle, Amanda B, Tomlinson, Ian, Consortium, Endometrial Cancer Association, Fitzgerald, Rebecca, Gharahkhani, Puya, Gockel, Ines, Jankowski, Janusz, Macgregor, Stuart, Schumacher, Johannes, Barnholtz-Sloan, Jill, Bondy, Melissa L, Houlston, Richard S, Jenkins, Robert B, Melin, Beatrice, Wrensch, Margaret, Brennan, Paul, Christiani, David C, Johansson, Mattias, Mckay, James, Aldrich, Melinda C, Amos, Christopher I, Landi, Maria Teresa, Tardon, Adonina, Consortium, International Lung Cancer, Bishop, D Timothy, Demenais, Florence, Goldstein, Alisa M, Iles, Mark M, Kanetsky, Peter A, Law, Matthew H, Consortium, Ovarian Cancer Association, Amundadottir, Laufey T, Stolzenberg-Solomon, Rachael, Wolpin, Brian M, Consortium, Pancreatic Cancer Cohort, Klein, Alison, Petersen, Gloria, Risch, Harvey, Consortium, The PRACTICAL Consortium Pancreatic Cancer Case-Control, Chanock, Stephen J, Purdue, Mark P, Scelo, Ghislaine, Pharoah, Paul, Kar, Siddhartha, Hung, Rayjean J, Pasaniuc, Bogdan, and Kraft, Peter
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Human Genome ,Genetics ,Digestive Diseases ,Prevention ,Clinical Research ,Urologic Diseases ,Cancer ,Rare Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Male ,Humans ,Genome-Wide Association Study ,Genetic Predisposition to Disease ,Neoplasms ,Risk Factors ,Transcriptome ,Polymorphism ,Single Nucleotide ,Breast Cancer Association Consortium ,Colorectal Transdisciplinary Study (CORECT) ,Colon Cancer Family Registry Study (CCFR) ,Genetics And Epidemiology Of Colorectal Cancer Consortium ,Endometrial Cancer Association Consortium ,International Lung Cancer Consortium ,Ovarian Cancer Association Consortium ,Pancreatic Cancer Cohort Consortium ,Pancreatic Cancer Case-Control Consortium (Panc4) ,The PRACTICAL Consortium ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
BackgroundThe shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from 12 cancer genome-wide association studies (GWAS) to quantify pairwise genome-wide genetic correlations across cancers and identify novel cancer susceptibility loci.MethodsWe collected GWAS summary statistics for 12 solid cancers based on 376 759 participants with cancer and 532 864 participants without cancer of European ancestry. The included cancer types were breast, colorectal, endometrial, esophageal, glioma, head and neck, lung, melanoma, ovarian, pancreatic, prostate, and renal cancers. We conducted cross-cancer GWAS and transcriptome-wide association studies to discover novel cancer susceptibility loci. Finally, we assessed the extent of variant-specific pleiotropy among cancers at known and newly identified cancer susceptibility loci.ResultsWe observed widespread but modest genome-wide genetic correlations across cancers. In cross-cancer GWAS and transcriptome-wide association studies, we identified 15 novel cancer susceptibility loci. Additionally, we identified multiple variants at 77 distinct loci with strong evidence of being associated with at least 2 cancer types by testing for pleiotropy at known cancer susceptibility loci.ConclusionsOverall, these results suggest that some genetic risk variants are shared among cancers, though much of cancer heritability is cancer-specific and thus tissue-specific. The increase in statistical power associated with larger sample sizes in cross-disease analysis allows for the identification of novel susceptibility regions. Future studies incorporating data on multiple cancer types are likely to identify additional regions associated with the risk of multiple cancer types.
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- 2023
19. Accuracy of HPV E6/E7 oncoprotein tests to detect high-grade cervical lesions: a systematic literature review and meta-analysis
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Downham, Laura, Jaafar, Iman, Rol, Mary Luz, Nyawira Nyaga, Victoria, Valls, Joan, Baena, Armando, Zhang, Li, Gunter, Marc J., Arbyn, Marc, and Almonte, Maribel
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- 2024
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20. Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis
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Morales-Berstein, Fernanda, Biessy, Carine, Viallon, Vivian, Goncalves-Soares, Ana, Casagrande, Corinne, Hémon, Bertrand, Kliemann, Nathalie, Cairat, Manon, Blanco Lopez, Jessica, Al Nahas, Aline, Chang, Kiara, Vamos, Eszter, Rauber, Fernanda, Bertazzi Levy, Renata, Barbosa Cunha, Diana, Jakszyn, Paula, Ferrari, Pietro, Vineis, Paolo, Masala, Giovanna, Catalano, Alberto, Sonestedt, Emily, Borné, Yan, Katzke, Verena, Bajracharya, Rashmita, Agnoli, Claudia, Guevara, Marcela, Heath, Alicia, Radoï, Loredana, Mancini, Francesca, Weiderpass, Elisabete, Huerta, José María, Sánchez, María-José, Tjønneland, Anne, Kyrø, Cecilie, Schulze, Matthias B., Skeie, Guri, Lukic, Marko, Braaten, Tonje, Gunter, Marc, Millett, Christopher, Agudo, Antonio, Brennan, Paul, Borges, M. Carolina, Richmond, Rebecca C., Richardson, Tom G., Davey Smith, George, Relton, Caroline L., and Huybrechts, Inge
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- 2024
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21. Lifestyle changes in middle age and risk of cancer: evidence from the European Prospective Investigation into Cancer and Nutrition
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Botteri, Edoardo, Peveri, Giulia, Berstad, Paula, Bagnardi, Vincenzo, Hoff, Geir, Heath, Alicia K., Cross, Amanda J., Vineis, Paolo, Dossus, Laure, Johansson, Mattias, Freisling, Heinz, Matta, Komodo, Huybrechts, Inge, Chen, Sairah L. F., B. Borch, Kristin, Sandanger, Torkjel M., H. Nøst, Therese, Dahm, Christina C., Antoniussen, Christian S., Tin Tin, Sandar, Fournier, Agnès, Marques, Chloé, Artaud, Fanny, Sánchez, Maria-José, Guevara, Marcela, Santiuste, Carmen, Agudo, Antonio, Bajracharya, Rashmita, Katzke, Verena, Ricceri, Fulvio, Agnoli, Claudia, Bergmann, Manuela M., Schulze, Matthias B., Panico, Salvatore, Masala, Giovanna, Tjønneland, Anne, Olsen, Anja, Stocks, Tanja, Manjer, Jonas, Aizpurua-Atxega, Amaia, Weiderpass, Elisabete, Riboli, Elio, Gunter, Marc J., and Ferrari, Pietro
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- 2024
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22. Reproducibility and dietary correlates of plasma polyphenols in the JPHC-NEXT Protocol Area study
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Mori, Nagisa, Murphy, Neil, Sawada, Norie, Achaintre, David, Yamaji, Taiki, Scalbert, Augustin, Ishihara, Junko, Takachi, Ribeka, Nakamura, Kazutoshi, Tanaka, Junta, Iwasaki, Motoki, Iso, Hiroyasu, Inoue, Manami, Gunter, Marc J., and Tsugane, Shoichiro
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- 2024
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23. Food consumption by degree of food processing and risk of type 2 diabetes mellitus: a prospective cohort analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Dicken, Samuel J., Dahm, Christina C., Ibsen, Daniel B., Olsen, Anja, Tjønneland, Anne, Louati-Hajji, Mariem, Cadeau, Claire, Marques, Chloé, Schulze, Matthias B., Jannasch, Franziska, Baldassari, Ivan, Manfredi, Luca, Santucci de Magistris, Maria, Sánchez, Maria-Jose, Castro-Espin, Carlota, Palacios, Daniel Rodríguez, Amiano, Pilar, Guevara, Marcela, van der Schouw, Yvonne T., Boer, Jolanda M.A., Verschuren, W.M. Monique, Sharp, Stephen J., Forouhi, Nita G., Wareham, Nicholas J., Vamos, Eszter P., Chang, Kiara, Vineis, Paolo, Heath, Alicia K., Gunter, Marc J., Nicolas, Geneviève, Weiderpass, Elisabete, Huybrechts, Inge, and Batterham, Rachel L.
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- 2024
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24. Nutritional quality of diet characterized by the Nutri-Score profiling system and cardiovascular disease risk: a prospective study in 7 European countries
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Deschasaux-Tanguy, Mélanie, Huybrechts, Inge, Julia, Chantal, Hercberg, Serge, Sarda, Barthélémy, Fialon, Morgane, Arnault, Nathalie, Srour, Bernard, Kesse-Guyot, Emmanuelle, Fezeu, Léopold K., Biessy, Carine, Casagrande, Corinne, Hemon, Bertrand, Weiderpass, Elisabete, Pinho, Maria G.M., Murphy, Neil, Freisling, Heinz, Ferrari, Pietro, Tjønneland, Anne, Nielsen Petersen, Kristina Elin, Katzke, Verena, Kaaks, Rudolf, Schulze, Matthias B., Masala, Giovanna, Pala, Valeria, Panico, Salvatore, Ricceri, Fulvio, Verschuren, W.M.Monique, Boer, Jolanda M.A., van der Schouw, Yvonne T., Skeie, Guri, Agudo, Antonio, Molina-Montes, Esther, Huerta, José María, Moreno-Iribas, Conchi, Ericson, Ulrika, Sonestedt, Emily, Strid, Anna, Oskarsson, Viktor, Tong, Tammy Y.N., Heath, Alicia K., Aglago, Elom K., Danesh, John, Riboli, Elio, Gunter, Marc J., and Touvier, Mathilde
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- 2024
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25. Circulating inflammatory and immune response proteins and endometrial cancer risk: a nested case-control study and Mendelian randomization analyses
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Wang, Sabrina E., Viallon, Vivian, Lee, Matthew, Dimou, Niki, Hamilton, Fergus, Biessy, Carine, O'Mara, Tracy, Kyrgiou, Maria, Crosbie, Emma J., Truong, Therese, Severi, Gianluca, Kaaks, Rudolf, Fortner, Renée Turzanski, Schulze, Matthias B., Bendinelli, Benedetta, Sabina, Sieri, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Crous-Bou, Marta, Sánchez, Maria-Jose, Aizpurua, Amaia, Palacios, Daniel Rodriguez, Guevara, Marcela, Travis, Ruth C., Tsilidis, Konstantinos K., Heath, Alicia, Yarmolinsky, James, Rinaldi, Sabina, Gunter, Marc J., and Dossus, Laure
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- 2024
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26. Food biodiversity and gastrointestinal cancer risk in nine European countries: Analysis within a prospective cohort study
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Huybrechts, Inge, Chimera, Bernadette, Hanley-Cook, Giles T., Biessy, Carine, Deschasaux-Tanguy, Mélanie, Touvier, Mathilde, Kesse-Guyot, Emmanuelle, Srour, Bernard, Baudry, Julia, Berlivet, Justine, Casagrande, Corinne, Nicolas, Geneviève, Lopez, Jessica Blanco, Millett, Christopher J., Cakmak, Emine Koc, Robinson, Oliver J.K., Murray, Kris A., Schulze, Matthias B., Masala, Giovanna, Guevara, Marcela, Bodén, Stina, Cross, Amanda J., Tsilidis, Kostas, Heath, Alicia K., Panico, Salvatore, Amiano, Pilar, Huerta, José Ma, Key, Tim, Ericson, Ulrika, Stocks, Tanja, Lundblad, Marie Wasmuth, Skeie, Guri, Sacerdote, Carlotta, Katzke, Verena, Playdon, Mary C., Ferrari, Pietro, Vineis, Paolo, Lachat, Carl, and Gunter, Marc J.
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- 2024
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27. Genetically determined circulating resistin concentrations and risk of colorectal cancer: a two-sample Mendelian randomization study
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Pham, Thu Thi, Nimptsch, Katharina, Papadimitriou, Nikos, Aleksandrova, Krasimira, Jenab, Mazda, Gunter, Marc J., Le Marchand, Loic, Li, Li, Lynch, Brigid M., Castellví-Bel, Sergi, Phipps, Amanda I., Schmit, Stephanie L., Brenner, Hermann, Ogino, Shuji, Giovannucci, Edward, and Pischon, Tobias
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- 2023
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28. Circulating hormones and risk of gastric cancer by subsite in three cohort studies
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Sanikini, Harinakshi, Biessy, Carine, Rinaldi, Sabina, Navionis, Anne-Sophie, Gicquiau, Audrey, Keski-Rahkonen, Pekka, Kiss, Agneta, Weinstein, Stephanie J., Albanes, Demetrius, Agudo, Antonio, Jenab, Mazda, Riboli, Elio, Gunter, Marc J., Murphy, Gwen, and Cross, Amanda J.
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- 2023
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29. Diet and lifestyle in relation to small intestinal cancer risk: findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Ersoy Guller, Zeynep, Harewood, Rhea N., Weiderpass, Elisabete, Huybrechts, Inge, Jenab, Mazda, Huerta, José María, Sánchez, Maria-Jose, Jakszyn, Paula, Amiano, Pilar, Ardanaz, Eva, Agnoli, Claudia, Tumino, Rosario, Palli, Domenico, Skeie, Guri, Manjer, Jonas, Papier, Keren, Tjønneland, Anne, Eriksen, Anne Kirstine, Schulze, Matthias B., Kaaks, Rudolf, Katzke, Verena, Bergmann, Manuela M., Riboli, Elio, Gunter, Marc J., and Cross, Amanda J.
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- 2023
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30. Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk.
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Tian, Yu, Kim, Andre E, Bien, Stephanie A, Lin, Yi, Qu, Conghui, Harrison, Tabitha A, Carreras-Torres, Robert, Díez-Obrero, Virginia, Dimou, Niki, Drew, David A, Hidaka, Akihisa, Huyghe, Jeroen R, Jordahl, Kristina M, Morrison, John, Murphy, Neil, Obón-Santacana, Mireia, Ulrich, Cornelia M, Ose, Jennifer, Peoples, Anita R, Ruiz-Narvaez, Edward A, Shcherbina, Anna, Stern, Mariana C, Su, Yu-Ru, van Duijnhoven, Franzel JB, Arndt, Volker, Baurley, James W, Berndt, Sonja I, Bishop, D Timothy, Brenner, Hermann, Buchanan, Daniel D, Chan, Andrew T, Figueiredo, Jane C, Gallinger, Steven, Gruber, Stephen B, Harlid, Sophia, Hoffmeister, Michael, Jenkins, Mark A, Joshi, Amit D, Keku, Temitope O, Larsson, Susanna C, Le Marchand, Loic, Li, Li, Giles, Graham G, Milne, Roger L, Nan, Hongmei, Nassir, Rami, Ogino, Shuji, Budiarto, Arif, Platz, Elizabeth A, Potter, John D, Prentice, Ross L, Rennert, Gad, Sakoda, Lori C, Schoen, Robert E, Slattery, Martha L, Thibodeau, Stephen N, Van Guelpen, Bethany, Visvanathan, Kala, White, Emily, Wolk, Alicja, Woods, Michael O, Wu, Anna H, Campbell, Peter T, Casey, Graham, Conti, David V, Gunter, Marc J, Kundaje, Anshul, Lewinger, Juan Pablo, Moreno, Victor, Newcomb, Polly A, Pardamean, Bens, Thomas, Duncan C, Tsilidis, Konstantinos K, Peters, Ulrike, Gauderman, W James, Hsu, Li, and Chang-Claude, Jenny
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Humans ,Colorectal Neoplasms ,Estrogens ,Progestins ,Risk Factors ,Case-Control Studies ,Menopause ,Polymorphism ,Single Nucleotide ,Female ,Aging ,Digestive Diseases ,Estrogen ,Colo-Rectal Cancer ,Genetics ,Prevention ,Human Genome ,Clinical Research ,Cancer ,2.1 Biological and endogenous factors ,Aetiology ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundThe use of menopausal hormone therapy (MHT) may interact with genetic variants to influence colorectal cancer (CRC) risk.MethodsWe conducted a genome-wide, gene-environment interaction between single nucleotide polymorphisms and the use of any MHT, estrogen only, and combined estrogen-progestogen therapy with CRC risk, among 28 486 postmenopausal women (11 519 CRC patients and 16 967 participants without CRC) from 38 studies, using logistic regression, 2-step method, and 2- or 3-degree-of-freedom joint test. A set-based score test was applied for rare genetic variants.ResultsThe use of any MHT, estrogen only and estrogen-progestogen were associated with a reduced CRC risk (odds ratio [OR] = 0.71, 95% confidence interval [CI] = 0.64 to 0.78; OR = 0.65, 95% CI = 0.53 to 0.79; and OR = 0.73, 95% CI = 0.59 to 0.90, respectively). The 2-step method identified a statistically significant interaction between a GRIN2B variant rs117868593 and MHT use, whereby MHT-associated CRC risk was statistically significantly reduced in women with the GG genotype (OR = 0.68, 95% CI = 0.64 to 0.72) but not within strata of GC or CC genotypes. A statistically significant interaction between a DCBLD1 intronic variant at 6q22.1 (rs10782186) and MHT use was identified by the 2-degree-of-freedom joint test. The MHT-associated CRC risk was reduced with increasing number of rs10782186-C alleles, showing odds ratios of 0.78 (95% CI = 0.70 to 0.87) for TT, 0.68 (95% CI = 0.63 to 0.73) for TC, and 0.66 (95% CI = 0.60 to 0.74) for CC genotypes. In addition, 5 genes in rare variant analysis showed suggestive interactions with MHT (2-sided P
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- 2022
31. Folate intake and colorectal cancer risk according to genetic subtypes defined by targeted tumor sequencing
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Aglago, Elom K, Qu, Conghui, Harlid, Sophia, Phipps, Amanda I, Steinfelder, Robert S, Ogino, Shuji, Thomas, Claire E, Hsu, Li, Toland, Amanda E, Brenner, Hermann, Berndt, Sonja I, Buchanan, Daniel D, Campbell, Peter T, Cao, Yin, Chan, Andrew T, Drew, David A, Figueiredo, Jane C, French, Amy J, Gallinger, Steven, Georgeson, Peter, Giannakis, Marios, Goode, Ellen L, Gruber, Stephen B, Gunter, Marc J, Harrison, Tabitha A, Hoffmeister, Michael, Huang, Wen-Yi, Hullar, Meredith AJ, Huyghe, Jeroen R, Jenkins, Mark A, Lynch, Brigid M, Moreno, Victor, Murphy, Neil, Newton, Christina C, Nowak, Jonathan A, Obón-Santacana, Mireia, Sun, Wei, Ugai, Tomotaka, Um, Caroline Y, Zaidi, Syed H, Tsilidis, Konstantinos K, van Guelpen, Bethany, and Peters, Ulrike
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- 2024
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32. General and abdominal adiposity and hypertension in eight world regions: a pooled analysis of 837 population-based studies with 7·5 million participants
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Zhou, Bin, Bennett, James E, Wickham, Aidan P, Singleton, Rosie K, Mishra, Anu, Carrillo-Larco, Rodrigo M, Ikeda, Nayu, Jain, Lakshya, Barradas-Pires, Ana, Heap, Rachel A, Lhoste, Victor PF, Sheffer, Kate E, Phelps, Nowell H, Rayner, Archie W, Gregg, Edward W, Woodward, Mark, Stevens, Gretchen A, Iurilli, Maria LC, Danaei, Goodarz, Di Cesare, Mariachiara, Aguilar-Salinas, Carlos A, Ahmad, Noor Ani, Bovet, Pascal, Chen, Zhengming, Damasceno, Albertino, Filippi, Sarah L, Janszky, Imre, Kengne, Andre P, Khang, Young-Ho, Khunti, Kamlesh, Laxmaiah, Avula, Lim, Lee-Ling, Lissner, Lauren, Margozzini, Paula, Mbanya, Jean Claude N, McGarvey, Stephen T, Shaw, Jonathan E, Söderberg, Stefan, Soto-Mota, Luis Adrián, Wang, Junyang, Zaccardi, Francesco, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Aekplakorn, Wichai, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkhatib, Buthaina M, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amougou, Norbert, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Auvinen, Juha, Avdičová, Mária, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Bacopoulou, Flora, Bahijri, Suhad, Bajramovic, Izet, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, José R, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Basit, Abdul, Bastos, Joao Luiz, Batieha, Anwar M, Batista, Aline P, Batista, Rosangela L, Battakova, Zhamilya, Baur, Louise A, Bayauli, Pascal M, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedek, Theodora, Benedics, Judith, Benet, Mikhail, Benitez Rolandi, Gilda Estela, Benzeval, Michaela, Bere, Elling, Berger, Nicolas, Bergh, Ingunn Holden, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bettiol, Heloísa, Beybey, Augustin F, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bhargava, Santosh K, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boggia, Jose G, Bogova, Elena, Bonaccio, Marialaura, Bonilla-Vargas, Alice, Borghs, Herman, Botomba, Steve, Bourne, Rupert, Boymatova, Khadichamo, Braeckman, Lutgart, Braithwaite, Tasanee, Brajkovich, Imperia, Branca, Francesco, Brenner, Hermann, Brewster, Lizzy M, Briceño, Yajaira, Brinduse, Lacramioara, Bringolf-Isler, Bettina, Brito, Miguel, Brug, Johannes, Bugge, Anna, Buntinx, Frank, Buoncristiano, Marta, Burns, Con, Cabrera de León, Antonio, Caixeta, Roberta B, Cama, Tilema, Can, Günay, Cândido, Ana Paula C, Cañete, Felicia, Capanzana, Mario V, Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardoso, Viviane C, Carlsson, Axel C, Casanueva, Felipe F, Casas, Maribel, Censi, Laura, Cervantes‐Loaiza, Marvin, Chamnan, Parinya, Chamukuttan, Snehalatha, Chan, Queenie, Chaturvedi, Nish, Chen, Fangfang, Chen, Huashuai, Chen, Long-Sheng, Cheng, Yiling J, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chinapaw, Mai JM, Chinnock, Anne, Chiolero, Arnaud, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Chong, Chean Lin, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cirillo, Massimo, Claessens, Frank, Clare, Philip, Cohen, Emmanuel, Confortin, Susana C, Coppinger, Tara C, Cortés, Lilia Yadira, Cosmin, Cojocaru R, Costanzo, Simona, Cowan, Melanie J, Cowell, Chris, Crampin, Amelia C, Cross, Amanda J, Crujeiras, Ana B, Cruz, Juan J, Cucu, Alexandra M, Cureau, Felipe V, Cuschieri, Sarah, D'Arrigo, Graziella, d'Orsi, Eleonora, da Silva-Ferreira, Haroldo, Dahm, Christina C, Dallongeville, Jean, Dankner, Rachel, Davletov, Kairat, de Assis Guedes de Vasconcelos, Francisco, de Assis, Maria Alice Altenburg, De Bacquer, Dirk, De Bacquer, Jaco, de Bont, Jeroen, De Curtis, Amalia, de Fragas Hinnig, Patrícia, de Gaetano, Giovanni, De Henauw, Stefaan, De Miguel-Etayo, Pilar, de Oliveira, Paula Duarte, de Paiva, Karina Mary, De Ridder, Karin, de Valois Correia Júnior, Marco Aurélio, Deepa, Mohan, DeGennaro, Vincent Jr, Demarest, Stefaan, Dennison, Elaine, Deschamps, Valérie, Dhimal, Meghnath, Díez Ripollés, María Pilar, Dika, Zivka, Djalalinia, Shirin, Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Donoso, Silvana P, Dorobantu, Maria, Dörr, Marcus, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Duante, Charmaine A, Duboz, Priscilla, Duda, Rosemary B, Duleva, Vesselka L, Dushpanova, Anar, Dyussupova, Azhar, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eghtesad, Sareh, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Elosua, Roberto, Enang, Ofem, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Esmaeili, Ali, Evans, Roger G, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farzadfar, Farshad, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Fernando, Desha R, Ferrante, Daniel, Ferrari, Gerson, Ferrari, Marika, Ferreccio, Catterina, Ferrer, Eldridge, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fink, Günther, Fisberg, Mauro, Forsner, Maria, Fottrell, Edward F, Fouad, Heba M, Francis, Damian K, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Furdela, Viktoriya, Furusawa, Takuro, Gabriela, Stefan Adela, Gaciong, Zbigniew, Galán Cuesta, Manuel, Galbarczyk, Andrzej, Galcheva, Sonya V, Galfo, Myriam, Garcia-de-la-Hera, Manoli, Garcia, Pablo, Garnett, Sarah P, Gasull, Magda, Gazzinelli, Andrea, Gehring, Ulrike, Gerdts, Eva, Ghaderi, Ebrahim, Ghamari, Seyyed-Hadi, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Ghimire, Anup, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Glushkova, Natalya, Godara, Ramesh, Godos, Justyna, Goldberg, Marcel, Gómez, Georgina, Gómez Gómez, Jesús Humberto, Gomez, Luis F, Gómez, Santiago F, Gomula, Aleksandra, Gonçalves Cordeiro da Silva, Bruna, Gonçalves, Helen, Gonçalves, Mauer, González-Alvarez, Ana D, Gonzalez-Chica, David A, González-Gil, Esther M, Gonzalez-Gross, Marcela, González-Rivas, Juan P, Gonzalez, Angel R, Gottrand, Frederic, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G, Grodzicki, Tomasz, Grøholt, Else Karin, Grøntved, Anders, Guajardo, Viviana, Guallar-Castillón, Pilar, Guerchet, Maëlenn, Guerrero, Ramiro, Guimaraes, Andre L, Gujral, Unjali P, Gulliford, Martin C, Gunter, Marc J, Gupta, Rajeev, Gureje, Oye, Gurinović, Mirjana A, Gurzkowska, Beata, Gutierrez, Laura, Gwee, Xinyi, Haghshenas, Rosa, Hakimi, Hamid, Halkjær, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hanekom, Willem A, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Hao, Jie, Hardman, Carla Menêses, Hardy, Louise, Hari Kumar, Rachakulla, Harooni, Javad, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, Heinen, Mirjam, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Hernandez Cadena, Leticia, Herrala, Sauli, Herrera-Cuenca, Marianella, Herrera, Victor M, Herter-Aeberli, Isabelle, Herzig, Karl-Heinz, Heshmat, Ramin, Hill, Allan G, Ho, Sai Yin, Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hoogendijk, Emiel O, Horimoto, Andrea RVR, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Huerta, José María, Huhtaniemi, Ilpo Tapani, Huiart, Laetitia, Huidumac Petrescu, Constanta, Huisman, Martijn, Husseini, Abdullatif, Huybrechts, Inge, Hwalla, Nahla, Iacoviello, Licia, Iakupova, Ellina M, Iannone, Anna G, Igland, Jannicke, Ijoma, Chinwuba, Iotova, Violeta, Irazola, Vilma E, Ishida, Takafumi, Isiguzo, Godsent C, Islam, Muhammad, Islam, Sheikh Mohammed Shariful, Islek, Duygu, Ittermann, Till, Ivanova-Pandourska, Ivaila Y, Iwasaki, Masanori, Jääskeläinen, Tuija, Jackson, Rod T, Jaddou, Hashem Y, Jadoul, Michel, Jafar, Tazeen, Jan, Nataša, Janus, Edward, Jarani, Juel, Jarnig, Gerald, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelaković, Ana, Jelaković, Bojan, Jha, Anjani Kumar, Jimenez, Ramon O, Jöckel, Karl-Heinz, Joffres, Michel, Jokelainen, Jari J, Jonas, Jost B, Joshi, Pradeep, Joshi, Rohina, Josipović, Josipa, Joukar, Farahnaz, Jóźwiak, Jacek J, Juolevi, Anne, Juresa, Vesna, Jureša, Vesna, Kaaks, Rudolf, Kaducu, Felix O, Kadvan, Agnes L, Kafatos, Anthony, Kajantie, Eero O, Kakutia, Natia, Kállayová, Daniela, Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Kannan, Srinivasan, Kapantais, Efthymios, Karaglani, Eva, Karakosta, Argyro, Karki, Khem B, Kassi Anicet, Adoubi, Katibeh, Marzieh, Katulanda, Prasad, Katzmarzyk, Peter T, Kauhanen, Jussi, Kazakbaeva, Gyulli M, Kaze, François F, Ke, Calvin, Keinänen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kelleher, Cecily, Kemper, Han CG, Keramati, Maryam, Kersting, Mathilde, Khader, Yousef Saleh, Khaledifar, Arsalan, Khalili, Davood, Kheiri, Bahareh, Kheradmand, Motahareh, Khosravi, Alireza, Kiechl-Kohlendorfer, Ursula, Kiechl, Sophia J, Kiechl, Stefan, Kim, Hyeon Chang, Klakk, Heidi, Klanarong, Suntara, Klanova, Jana, Klimek, Magdalena, Knoflach, Michael, Kobel, Susanne, Koirala, Bhawesh, Kolle, Elin, Kolsteren, Patrick, König, Jürgen, Korpelainen, Raija, Korrovits, Paul, Korzycka, Magdalena, Kos, Jelena, Koskinen, Seppo, Koussoh Simone, Malik, Kovács, Éva, Kovalskys, Irina, Kowlessur, Sudhir, Koziel, Slawomir, Kratenova, Jana, Kratzer, Wolfgang, Kriemler, Susi, Kristensen, Peter Lund, Krizan, Helena, Kroker-Lobos, Maria F, Krokstad, Steinar, Kruger, Herculina S, Kruger, Ruan, Kryst, Łukasz, Kubinova, Ruzena, Kujala, Urho M, Kujundzic, Enisa, Kulaga, Zbigniew, Kulimbet, Mukhtar, Kumari, Meena, Kunešová, Marie, Kurjata, Pawel, Kyobutungi, Catherine, La, Quang Ngoc, Labadarios, Demetre, Lachat, Carl, Lai, Daphne, Laid, Youcef, Lall, Lachmie, Landaeta Jimenez, Maritza, Landais, 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Sabine, Schmidt, Amand Floriaan, Schmidt, Börge, Schmidt, Carsten O, Schöttker, Ben, Schramm, Sara, Schramm, Stine, Schröder, Helmut, Schultsz, Constance, Schutte, Aletta E, Sebert, Sylvain, Sedaghattalab, Moslem, Sein, Aye Aye, Sen, Abhijit, Sepanlou, Sadaf G, Sequera, Guillermo, Ševčíková, Ľudmila, Sewpaul, Ronel, Shamah-Levy, Teresa, Shamshirgaran, Seyed Morteza, Sharafkhah, Maryam, Sharma, Sanjib K, Sharman, Almaz, Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shengelia, Lela, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shiri, Rahman, Shoranov, Marat, Shrestha, Namuna, Si-Ramlee, Khairil, Sibai, Abla M, Sidossis, Labros S, Silva, Antonio M, Silva, Caroline Ramos de Moura, Silva, Diego Augusto Santos, Silva, Kelly Samara, Sim, Xueling, Simon, Mary, Sjöström, Michael, Skoblina, Natalia A, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemysław, Smeeth, Liam, Smith, Lee, Soares, Fernanda Cunha, Sobek, Grzegorz, Sobngwi, Eugène, Sodemann, Morten, Soemantri, Agustinus, Solfrizzi, Vincenzo, Somi, Mohammad Hossein, Sørgjerd, Elin P, Sorić, Maroje, Soto-Rojas, Victoria E, Soumaré, Aïcha, Sousa-Poza, Alfonso, Spiroski, Igor, Staessen, Jan A, Stang, Andreas, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Stergiou, George S, Stokwiszewski, Jakub, Stoyanova, Ekaterina, Stratton, Gareth, Stronks, Karien, Sturua, Lela, Suarez-Ortegón, Milton F, Suebsamran, Phalakorn, Sulo, Gerhard, Sundström, Johan, Suriyawongpaisal, Paibul, Swinburn, Boyd A, Sylva, René Charles, Szponar, Lucjan, Tai, E Shyong, Tambalis, Konstantinos D, Tamosiunas, Abdonas, Tanabayev, Baimakhan, Tanrygulyyeva, Maya, Tarawneh, Mohammed Rasoul, Tarp, Jakob, Tarqui-Mamani, Carolina B, Taxová Braunerová, Radka, Te Velde, Saskia, Tebar, William R, Tell, Grethe S, Tello, Tania, Thankappan, KR, Theodoridis, Xenophon, Thirunavukkarasu, Sathish, Thomas, Nihal, Thrift, Amanda G, Tichá, Ľubica, Timmermans, Erik J, Tjandrarini, Dwi Hapsari, Tjonneland, Anne, Tolstrup, Janne S, Topbas, Murat, Torres-Collado, Laura, Touloumi, Giota, Traissac, Pierre, Triantafyllou, Areti, Trivedi, Atul, Tshepo, Lechaba, Tsintavis, Panagiotis, Tuitele, John, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Turley, Maria L, Tzala, Evangelia, Tzotzas, Themistoklis, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice, Ukoli, Flora AM, Usupova, Zhamyila, Uusitalo, Hannu MT, Uysal, Nalan, Valdivia, Gonzalo, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Lippevelde, Wendy, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varela-Moreiras, Gregorio, Vargas, Luz Nayibe, Vasan, Senthil K, Vasques, Daniel G, Vega, Tomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Verdot, Charlotte, Verloigne, Maïté, Veronesi, Giovanni, Verschuren, WM Monique, Verstraeten, Roosmarijn, Viet, Lucie, Vik, Frøydis N, Vilar, Monica, Villalpando, Salvador, Vioque, Jesus, Virtanen, Jyrki K, Visser, Marjolein, Viswanathan, Bharathi, Vladulescu, Mihaela, Völzke, Henry, Voutilainen, Ari, Vrijheid, Martine, Wade, Alisha N, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley Júnior, Rildo de Souza, Wang, Chongjian, Wang, Huijun, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wartha, Olivia, Weber, Adelheid, Webster-Kerr, Karen, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Westbury, Leo, Whincup, Peter H, Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wilks, Rainford J, Willeit, Karin, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Wu, Frederick C, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yan, Li, Yan, Weili, Yang, Yang, Yépez García, Martha, Yoosefi, Moein, Yoshihara, Akihiro, Younger-Coleman, Novie O, Yu, Yu-Ling, Yu, Yunjiang, Yusoff, Ahmad Faudzi, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zapata, Maria Elisa, Zaw, Ko Ko, Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zhang, Bing, Zhang, Zhen-Yu, Zhecheva, Yanitsa V, Zholdin, Bekbolat, Zimmet, Paul, Zins, Marie, Zuñiga Cisneros, Julio, Zuziak, Monika, and Ezzati, Majid
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- 2024
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33. Implications of food ultra-processing on cardiovascular risk considering plant origin foods: an analysis of the UK Biobank cohort
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Rauber, Fernanda, Laura da Costa Louzada, Maria, Chang, Kiara, Huybrechts, Inge, Gunter, Marc J., Monteiro, Carlos Augusto, Vamos, Eszter P., and Levy, Renata Bertazzi
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- 2024
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34. Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics
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Desai, Trishna A., Hedman, Åsa K., Dimitriou, Marios, Koprulu, Mine, Figiel, Sandy, Yin, Wencheng, Johansson, Mattias, Watts, Eleanor L., Atkins, Joshua R., Sokolov, Aleksandr V., Schiöth, Helgi B., Gunter, Marc J., Tsilidis, Konstantinos K., Martin, Richard M., Pietzner, Maik, Langenberg, Claudia, Mills, Ian G., Lamb, Alastair D., Mälarstig, Anders, Key, Tim J., Travis, Ruth C., and Smith-Byrne, Karl
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- 2024
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35. Probing the diabetes and colorectal cancer relationship using gene – environment interaction analyses
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Dimou, Niki, Kim, Andre E., Flanagan, Orlagh, Murphy, Neil, Diez-Obrero, Virginia, Shcherbina, Anna, Aglago, Elom K., Bouras, Emmanouil, Campbell, Peter T., Casey, Graham, Gallinger, Steven, Gruber, Stephen B., Jenkins, Mark A., Lin, Yi, Moreno, Victor, Ruiz-Narvaez, Edward, Stern, Mariana C., Tian, Yu, Tsilidis, Kostas K., Arndt, Volker, Barry, Elizabeth L., Baurley, James W., Berndt, Sonja I., Bézieau, Stéphane, Bien, Stephanie A., Bishop, D. Timothy, Brenner, Hermann, Budiarto, Arif, Carreras-Torres, Robert, Cenggoro, Tjeng Wawan, Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Chen, Xuechen, Conti, David V., Dampier, Christopher H., Devall, Matthew, Drew, David A., Figueiredo, Jane C., Giles, Graham G., Gsur, Andrea, Harrison, Tabitha A., Hidaka, Akihisa, Hoffmeister, Michael, Huyghe, Jeroen R., Jordahl, Kristina, Kawaguchi, Eric, Keku, Temitope O., Larsson, Susanna C., Le Marchand, Loic, Lewinger, Juan Pablo, Li, Li, Mahesworo, Bharuno, Morrison, John, Newcomb, Polly A., Newton, Christina C., Obon-Santacana, Mireia, Ose, Jennifer, Pai, Rish K., Palmer, Julie R., Papadimitriou, Nikos, Pardamean, Bens, Peoples, Anita R., Pharoah, Paul D. P., Platz, Elizabeth A., Potter, John D., Rennert, Gad, Scacheri, Peter C., Schoen, Robert E., Su, Yu-Ru, Tangen, Catherine M., Thibodeau, Stephen N., Thomas, Duncan C., Ulrich, Cornelia M., Um, Caroline Y., van Duijnhoven, Franzel J. B., Visvanathan, Kala, Vodicka, Pavel, Vodickova, Ludmila, White, Emily, Wolk, Alicja, Woods, Michael O., Qu, Conghui, Kundaje, Anshul, Hsu, Li, Gauderman, W. James, Gunter, Marc J., and Peters, Ulrike
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- 2023
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36. Genetically proxied glucose-lowering drug target perturbation and risk of cancer: a Mendelian randomisation analysis
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Yarmolinsky, James, Bouras, Emmanouil, Constantinescu, Andrei, Burrows, Kimberley, Bull, Caroline J., Vincent, Emma E., Martin, Richard M., Dimopoulou, Olympia, Lewis, Sarah J., Moreno, Victor, Vujkovic, Marijana, Chang, Kyong-Mi, Voight, Benjamin F., Tsao, Philip S., Gunter, Marc J., Hampe, Jochen, Pellatt, Andrew J., Pharoah, Paul D. P., Schoen, Robert E., Gallinger, Steven, Jenkins, Mark A., Pai, Rish K., Gill, Dipender, and Tsilidis, Kostas K.
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- 2023
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37. Longitudinal associations of sedentary behavior and physical activity with body composition in colorectal cancer survivors up to 2 years post treatment
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Kenkhuis, Marlou-Floor, Klingestijn, Mo, Fanshawe, Anne-Marie, Breukink, Stéphanie O., Janssen-Heijnen, Maryska L. G., Keulen, Eric T. P., Rinaldi, Sabina, Vineis, Paolo, Gunter, Marc J., Leitzmann, Michael F., Scalbert, Augustin, Weijenberg, Matty P., Bours, Martijn J. L., and van Roekel, Eline H.
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- 2023
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38. Genome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancer
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Papadimitriou, Nikos, Kim, Andre, Kawaguchi, Eric S., Morrison, John, Diez-Obrero, Virginia, Albanes, Demetrius, Berndt, Sonja I., Bézieau, Stéphane, Bien, Stephanie A., Bishop, D Timothy, Bouras, Emmanouil, Brenner, Hermann, Buchanan, Daniel D., Campbell, Peter T., Carreras-Torres, Robert, Chan, Andrew T., Chang-Claude, Jenny, Conti, David V., Devall, Matthew A., Dimou, Niki, Drew, David A., Gruber, Stephen B., Harrison, Tabitha A., Hoffmeister, Michael, Huyghe, Jeroen R., Joshi, Amit D., Keku, Temitope O., Kundaje, Anshul, Küry, Sébastien, Le Marchand, Loic, Lewinger, Juan Pablo, Li, Li, Lynch, Brigid M., Moreno, Victor, Newton, Christina C., Obón-Santacana, Mireia, Ose, Jennifer, Pellatt, Andrew J., Peoples, Anita R., Platz, Elizabeth A., Qu, Conghui, Rennert, Gad, Ruiz-Narvaez, Edward, Shcherbina, Anna, Stern, Mariana C., Su, Yu-Ru, Thomas, Duncan C., Thomas, Claire E., Tian, Yu, Tsilidis, Konstantinos K., Ulrich, Cornelia M., Um, Caroline Y., Visvanathan, Kala, Wang, Jun, White, Emily, Woods, Michael O., Schmit, Stephanie L., Macrae, Finlay, Potter, John D., Hopper, John L., Peters, Ulrike, Murphy, Neil, Hsu, Li, Gunter, Marc J., and Gauderman, W. James
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- 2024
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39. Adiposity and breast, endometrial, and colorectal cancer risk in postmenopausal women: Quantification of the mediating effects of leptin, C‐reactive protein, fasting insulin, and estradiol
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Dashti, S Ghazaleh, Simpson, Julie A, Viallon, Vivian, Karahalios, Amalia, Moreno‐Betancur, Margarita, Brasky, Theodore, Pan, Kathy, Rohan, Thomas E, Shadyab, Aladdin H, Thomson, Cynthia A, Wild, Robert A, Wassertheil‐Smoller, Sylvia, Ho, Gloria YF, Strickler, Howard D, English, Dallas R, and Gunter, Marc J
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Trials and Supportive Activities ,Nutrition ,Prevention ,Breast Cancer ,Digestive Diseases ,Aging ,Clinical Research ,Colo-Rectal Cancer ,Cancer ,Obesity ,Adiposity ,Body Mass Index ,Breast Neoplasms ,C-Reactive Protein ,Case-Control Studies ,Cohort Studies ,Colorectal Neoplasms ,Endometrial Neoplasms ,Estradiol ,Fasting ,Female ,Humans ,Insulin ,Leptin ,Postmenopause ,Risk Factors ,breast cancer ,causal mediation analysis ,colorectal cancer ,endometrial cancer ,estrogens ,inflammation ,insulin ,Biochemistry and Cell Biology ,Oncology and carcinogenesis - Abstract
BackgroundMechanisms underlying the adiposity-cancer relationship are incompletely understood. We quantified the mediating roles of C-reactive protein (CRP), leptin, fasting insulin, and estradiol in the effect of adiposity on estrogen receptor (ER)-positive breast, endometrial, and colorectal cancer risk in postmenopausal women.MethodsWe used a case-cohort study within the Women's Health Initiative Observational Study, analyzed as a cumulative sampling case-control study. The study included 188 breast cancer cases, 98 endometrial cancer cases, 193 colorectal cancer cases, and 285 controls. Interventional indirect and direct effects on the risk ratio (RR) scale were estimated using causal mediation analysis.ResultsFor breast cancer, the total effect RR for BMI ≥30 versus ≥18.5-
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- 2022
40. Genome-wide association study identifies tumor anatomical site-specific risk variants for colorectal cancer survival
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Labadie, Julia D, Savas, Sevtap, Harrison, Tabitha A, Banbury, Barb, Huang, Yuhan, Buchanan, Daniel D, Campbell, Peter T, Gallinger, Steven J, Giles, Graham G, Gunter, Marc J, Hoffmeister, Michael, Hsu, Li, Jenkins, Mark A, Lin, Yi, Ogino, Shuji, Phipps, Amanda I, Slattery, Martha L, Steinfelder, Robert S, Sun, Wei, Van Guelpen, Bethany, Hua, Xinwei, Figuieredo, Jane C, Pai, Rish K, Nassir, Rami, Qi, Lihong, Chan, Andrew T, Peters, Ulrike, and Newcomb, Polly A
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Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Epidemiology ,Health Sciences ,Oncology and Carcinogenesis ,Human Genome ,Cancer ,Colo-Rectal Cancer ,Prevention ,Digestive Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Adult ,Aged ,Aged ,80 and over ,Biomarkers ,Tumor ,Colorectal Neoplasms ,Databases ,Genetic ,Female ,Genetic Loci ,Genome-Wide Association Study ,Humans ,Male ,Middle Aged ,Neoplasm Staging ,Polymorphism ,Single Nucleotide ,Risk Assessment ,Risk Factors ,Young Adult - Abstract
Identification of new genetic markers may improve the prediction of colorectal cancer prognosis. Our objective was to examine genome-wide associations of germline genetic variants with disease-specific survival in an analysis of 16,964 cases of colorectal cancer. We analyzed genotype and colorectal cancer-specific survival data from a consortium of 15 studies. Approximately 7.5 million SNPs were examined under the log-additive model using Cox proportional hazards models, adjusting for clinical factors and principal components. Additionally, we ran secondary analyses stratifying by tumor site and disease stage. We used a genome-wide p-value threshold of 5 × 10-8 to assess statistical significance. No variants were statistically significantly associated with disease-specific survival in the full case analysis or in the stage-stratified analyses. Three SNPs were statistically significantly associated with disease-specific survival for cases with tumors located in the distal colon (rs698022, HR = 1.48, CI 1.30-1.69, p = 8.47 × 10-9) and the proximal colon (rs189655236, HR = 2.14, 95% CI 1.65-2.77, p = 9.19 × 10-9 and rs144717887, HR = 2.01, 95% CI 1.57-2.58, p = 3.14 × 10-8), whereas no associations were detected for rectal tumors. Findings from this large genome-wide association study highlight the potential for anatomical-site-stratified genome-wide studies to identify germline genetic risk variants associated with colorectal cancer-specific survival. Larger sample sizes and further replication efforts are needed to more fully interpret these findings.
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- 2022
41. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
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Alireza, Safarpour, Ali Reza, Safi, Sare, Safiri, Saeid, Saghi, Mohammad Hossien, Saidi, Olfa, Saieva, Calogero, Sakata, Satoko, Saki, Nader, Šalaj, Sanja, Salanave, Benoit, Salazar Martinez, Eduardo, Salhanova, Akkumis, Salmerón, Diego, Salomaa, Veikko, Salonen, Jukka T, Salvetti, Massimo, Samoutian, Margarita, Sánchez-Abanto, Jose, Sánchez Rodríguez, Inés, Sandjaja, Sans, Susana, Santa-Marina, Loreto, Santacruz, Ethel, Santos, Diana A, Santos, Ina S, Santos, Lèlita C, Santos, Maria Paula, Santos, Osvaldo, Santos, Rute, Santos, Tamara R, Saramies, Jouko L, Sardinha, Luis B, Sarrafzadegan, Nizal, Sathish, Thirunavukkarasu, Saum, Kai-Uwe, Savva, Savvas, Savy, Mathilde, Sawada, Norie, Sbaraini, Mariana, Scazufca, Marcia, Schaan, Beatriz D, Schaffrath Rosario, Angelika, Schargrodsky, Herman, Schienkiewitz, Anja, Schindler, Karin, Schipf, Sabine, Schmidt, Börge, Schmidt, Carsten O, Schmidt, Ida Maria, Schneider, Andrea, Schnohr, Peter, Schöttker, Ben, Schramm, Sara, Schramm, Stine, 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- 2024
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42. Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analyses
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Papadimitriou, Nikos, Qu, Conghui, Harrison, Tabitha A., Bever, Alaina M., Martin, Richard M., Tsilidis, Konstantinos K., Newcomb, Polly A., Thibodeau, Stephen N., Newton, Christina C., Um, Caroline Y., Obón-Santacana, Mireia, Moreno, Victor, Brenner, Hermann, Mandic, Marko, Chang-Claude, Jenny, Hoffmeister, Michael, Pellatt, Andrew J., Schoen, Robert E., Harlid, Sophia, Ogino, Shuji, Ugai, Tomotaka, Buchanan, Daniel D., Lynch, Brigid M., Gruber, Stephen B., Cao, Yin, Hsu, Li, Huyghe, Jeroen R., Lin, Yi, Steinfelder, Robert S., Sun, Wei, Van Guelpen, Bethany, Zaidi, Syed H., Toland, Amanda E., Berndt, Sonja I., Huang, Wen-Yi, Aglago, Elom K., Drew, David A., French, Amy J., Georgeson, Peter, Giannakis, Marios, Hullar, Meredith, Nowak, Johnathan A., Thomas, Claire E., Le Marchand, Loic, Cheng, Iona, Gallinger, Steven, Jenkins, Mark A., Gunter, Marc J., Campbell, Peter T., Peters, Ulrike, Song, Mingyang, Phipps, Amanda I., and Murphy, Neil
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- 2024
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43. Association between pre-diagnostic circulating lipid metabolites and colorectal cancer risk: a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Harewood, Rhea, Rothwell, Joseph A., Bešević, Jelena, Viallon, Vivian, Achaintre, David, Gicquiau, Audrey, Rinaldi, Sabina, Wedekind, Roland, Prehn, Cornelia, Adamski, Jerzy, Schmidt, Julie A., Jacobs, Inarie, Tjønneland, Anne, Olsen, Anja, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., Prada, Marcela, Masala, Giovanna, Agnoli, Claudia, Panico, Salvatore, Sacerdote, Carlotta, Jakszyn, Paula Gabriela, Sánchez, Maria-Jose, Castilla, Jesús, Chirlaque, María-Dolores, Atxega, Amaia Aizpurua, van Guelpen, Bethany, Heath, Alicia K., Papier, Keren, Tong, Tammy Y.N., Summers, Scott A., Playdon, Mary, Cross, Amanda J., Keski-Rahkonen, Pekka, Chajès, Véronique, Murphy, Neil, and Gunter, Marc J.
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- 2024
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44. Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis
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Landi, Maria Teresa, Stevens, Victoria, Wang, Ying, Albanes, Demetrios, Caporaso, Neil, Brennan, Paul, Amos, Christopher I., Shete, Sanjay, Hung, Rayjean J., Bickeböller, Heike, Risch, Angela, Houlston, Richard, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Johansson, Mattias, Wichmann, H-Erich, Christiani, David, Rennert, Gadi, Arnold, Susanne, Field, John K., Le Marchand, Loic, Melander, Olle, Brunnström, Hans, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A., Shen, Hongbing, Zienolddiny, Shan, Grankvist, Kjell, Johansson, Mikael, Teare, M. Dawn, Hong, Yun-Chul, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Eeles, Rosalind A., Haiman, Christopher A., Kote-Jarai, Zsofia, Schumacher, Fredrick R., Benlloch, Sara, Al Olama, Ali Amin, Muir, Kenneth R., Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Chanock, Stephen, Tangen, Catherine M., Batra, Jyotsna, Clements, Judith A., Grönberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Albanes, Demetrius, Weinstein, Stephanie J., Wolk, Alicja, West, Catharine M.L., Mucci, Lorelei A., Cancel-Tassin, Géraldine, Koutros, Stella, Sørensen, Karina Dalsgaard, Grindedal, Eli Marie, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong-Jie, Giles, Graham G., MacInnis, Robert J., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanfrod, Janet L., Cybulski, Cezary, Nordestgaard, Børge G., Nielsen, Sune F., Brenner, Hermann, Maier, Christiane, Logothetis, Christopher J., John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Castelao, Jose Esteban, Roobol, Monique J., Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albright, Lisa, Pandha, Hardev, Thibodeau, Stephen N., Hunter, David J., Kraft, Peter, Blot, William J., Riboli, Elio, Yarmolinsky, James, Robinson, Jamie W., Mariosa, Daniela, Karhunen, Ville, Huang, Jian, Dimou, Niki, Murphy, Neil, Burrows, Kimberley, Bouras, Emmanouil, Smith-Byrne, Karl, Lewis, Sarah J., Galesloot, Tessel E., Vermeulen, Sita, Martin, Paul, Hou, Lifang, Newcomb, Polly A., White, Emily, Wu, Anna H., Le Marchand, Loïc, Phipps, Amanda I., Buchanan, Daniel D., Zhao, Sizheng Steven, Gill, Dipender, Chanock, Stephen J., Purdue, Mark P., Davey Smith, George, Herzig, Karl-Heinz, Järvelin, Marjo-Riitta, Amos, Chris I., Dehghan, Abbas, Gunter, Marc J., Tsilidis, Kostas K., and Martin, Richard M.
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- 2024
- Full Text
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45. Impact of weight loss on cancer-related proteins in serum: results from a cluster randomised controlled trial of individuals with type 2 diabetes
- Author
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Bull, Caroline J., Hazelwood, Emma, Legge, Danny N., Corbin, Laura J., Richardson, Tom G., Lee, Matthew, Yarmolinsky, James, Smith-Byrne, Karl, Hughes, David A., Johansson, Mattias, Peters, Ulrike, Berndt, Sonja I., Brenner, Hermann, Burnett-Hartman, Andrea, Cheng, Iona, Kweon, Sun-Seog, Le Marchand, Loic, Li, Li, Newcomb, Polly A., Pearlman, Rachel, McConnachie, Alex, Welsh, Paul, Taylor, Roy, Lean, Mike E.J., Sattar, Naveed, Murphy, Neil, Gunter, Marc J., Timpson, Nicholas J., and Vincent, Emma E.
- Published
- 2024
- Full Text
- View/download PDF
46. Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and mortality: EPIC cohort study in 9 European countries
- Author
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Fiolet, Thibault, Nicolas, Geneviève, Casagrande, Corinne, Horvath, Zsuzsanna, Frenoy, Pauline, Weiderpass, Elisabete, Gunter, Marc J., Manjer, Jonas, Sonestedt, Emily, Palli, Domenico, Simeon, Vittorio, Tumino, Rosario, Bueno-de-Mesquita, Bas, Huerta, José María, Rodriguez-Barranco, Miguel, Abilleira, Eunate, Sacerdote, Carlotta, Schulze, Matthias B., Heath, Alicia K., Rylander, Charlotta, Skeie, Guri, Nøst, Therese Haugdahl, Tjønneland, Anne, Olsen, Anja, Pala, Valeria, Kvaskoff, Marina, Huybrechts, Inge, and Mancini, Francesca Romana
- Published
- 2024
- Full Text
- View/download PDF
47. The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study
- Author
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Bonet, Catalina, Crous-Bou, Marta, Tsilidis, Konstantinos K., Gunter, Marc J., Kaaks, Rudolf, Schulze, Matthias B., Fortner, Renée T., Antoniussen, Christian S., Dahm, Christina C., Mellemkjær, Lene, Tjønneland, Anne, Amiano, Pilar, Ardanaz, Eva, Colorado-Yohar, Sandra M., Rodriguez-Barranco, Miguel, Tin Tin, Sandar, Agnoli, Claudia, Masala, Giovanna, Panico, Salvatore, Sacerdote, Carlotta, May, Anne M., Borch, Kristin Benjaminsen, Rylander, Charlotta, Skeie, Guri, Christakoudi, Sofia, Aune, Dagfinn, Weiderpass, Elisabete, Dossus, Laure, Riboli, Elio, and Agudo, Antonio
- Published
- 2023
- Full Text
- View/download PDF
48. Dietary intake of total, heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study
- Author
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Aglago, Elom K., Cross, Amanda J., Riboli, Elio, Fedirko, Veronika, Hughes, David J., Fournier, Agnes, Jakszyn, Paula, Freisling, Heinz, Gunter, Marc J., Dahm, Christina C., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Boutron-Ruault, Marie-Christine, Rothwell, Joseph A., Severi, Gianluca, Katzke, Verena, Srour, Bernard, Schulze, Matthias B., Wittenbecher, Clemens, Palli, Domenico, Sieri, Sabina, Pasanisi, Fabrizio, Tumino, Rosario, Ricceri, Fulvio, Bueno-de-Mesquita, Bas, Derksen, Jeroen W. G., Skeie, Guri, Jensen, Torill Enget, Lukic, Marko, Sánchez, Maria-Jose, Amiano, Pilar, Colorado-Yohar, Sandra, Barricarte, Aurelio, Ericson, Ulrika, van Guelpen, Bethany, Papier, Keren, Knuppel, Anika, Casagrande, Corinne, Huybrechts, Inge, Heath, Alicia K., Tsilidis, Konstantinos K., and Jenab, Mazda
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- 2023
- Full Text
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49. Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies
- Author
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Fontvieille, Emma, Viallon, Vivian, Recalde, Martina, Cordova, Reynalda, Jansana, Anna, Peruchet-Noray, Laia, Lennon, Hannah, Heath, Alicia K., Aune, Dagfinn, Christakoudi, Sofia, Katzke, Verena, Kaaks, Rudolf, Inan-Eroglu, Elif, Schulze, Matthias B., Mellemkjær, Lene, Tjønneland, Anne, Overvad, Kim, Farràs, Marta, Petrova, Dafina, Amiano, Pilar, Chirlaque, María-Dolores, Moreno-Iribas, Conchi, Tin Tin, Sandar, Masala, Giovanna, Sieri, Sabina, Ricceri, Fulvio, Panico, Salvatore, May, Anne M., Monninkhof, Evelyn M., Weiderpass, Elisabete, Gunter, Marc J., Ferrari, Pietro, and Freisling, Heinz
- Published
- 2023
- Full Text
- View/download PDF
50. Untargeted plasma metabolomics and risk of colorectal cancer—an analysis nested within a large-scale prospective cohort
- Author
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Vidman, Linda, Zheng, Rui, Bodén, Stina, Ribbenstedt, Anton, Gunter, Marc J., Palmqvist, Richard, Harlid, Sophia, Brunius, Carl, and Van Guelpen, Bethany
- Published
- 2023
- Full Text
- View/download PDF
Catalog
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