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10. The characteristics of HIV-1 subtype B on phylogenetic dynamic and molecular transmission network in Fuyang City, China, 2011 to 2019

Author

Pan, Wenting, primary, Gao, Nannan, additional, Hu, Bing, additional, Yin, Yueqi, additional, Shen, Yuelan, additional, Yang, Xiaohui, additional, Wei, Wei, additional, Ni, Jie, additional, Dai, Seying, additional, Miao, Lifeng, additional, Qin, Yizu, additional, Jin, Lin, additional, Guo, Hongxiong, additional, and Wu, Jianjun, additional

Published
2023
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15. The Identification of A Novel HIV-1 Second-Generation Recombinant form (CRF01_AE/CRF07_BC) Among Men Who Have Sex with Men in Jiangsu, China

Author

Guo Hongxiong, Xu Xiaoqin, Hu Haiyang, Lu Jing, Zhou Ying, Wang Bei, Fu Gengfeng, Yin Yueqi, Xuan Yan, Chen Jianshuang, Yuan Defu, and Cheng Hao

Subjects
Genetics, Phylogenetic tree, Maximum likelihood, Human immunodeficiency virus (HIV), Biology, medicine.disease_cause, Genome, Virus, Men who have sex with men, law.invention, Infectious Diseases, law, Virology, medicine, Recombinant DNA
Abstract

Background: CRF01_AE and CRF07_BC are the two major HIV-1 virus strains circulating in China. The proportion of dominant subtypes (CRF01_AE and CRF07_BC) among MSM in Jiangsu province was over 80%. A large number of URFs have been found in China in recent years. Objective: This study aimed to report on novel HIV-1 recombinants. Method: We constructed Phylogenetic trees using the maximum likelihood (ML) method with 1000 bootstrap replicates in IQ-TREE 1.6.8 software and determined recombination breakpoints using SimPlot 3.5.1. Results: We identified a novel, second-generation HIV-1 recombinant (JS020202) between CRF01_ AE and CRF07_BC. The analysis of near full-length genome (NFLG) showed there were at least 8 breakpoints in the virus, which differed from any previously identified CRF and URF around the world. Conclusion: Novel diverse CRF01_AE/07_BC suggested the complexity trends of HIV-1 genetics. The emergency situation of diverse recombinant strains should be monitored continuously.

Published
2021
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20. Waning immunity and potential asymptomatic infection in 3–7 years old children who received one dose of measles-mumps-rubella vaccine: A 4-year prospective study

Author

Liu, Yuanbao, primary, Xiong, Yan, additional, Liang, Yaqiong, additional, Deng, Xiuying, additional, Hu, Ying, additional, Hu, Ran, additional, Chen, Qiang, additional, Tang, Fenyang, additional, Wang, Zhiguo, additional, Sun, Xiang, additional, Guo, Hongxiong, additional, Zhang, Lei, additional, and Zhu, Feng-Cai, additional

Published
2021
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28. Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy

Author

Zhou, Zhiyong, primary, Tang, Kevin, additional, Zhang, Guoqing, additional, Wadonda-Kabondo, Nellie, additional, Moyo, Kundai, additional, Rowe, Lori A., additional, DeVos, Joshua R., additional, Wagar, Nick, additional, Zheng, Du-Ping, additional, Guo, Hongxiong, additional, Nkengasong, John, additional, Frace, Mike, additional, Sammons, Scott, additional, and Yang, Chunfu, additional

Published
2018
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33. MicroRNA profiling in plasma of HIV-1 infected patients: potential markers of infection and immune status

Author

Hai-Yang Hu, Huan Xiping, Qi Yuhua, Minghao Zhou, Guo Hongxiong, Peng Xu, Zhiyang Shi, Zheng Zhu, and Lunbiao Cui

Subjects
Immune status, T cell, Cell, Public Health, Environmental and Occupational Health, Human immunodeficiency virus (HIV), Biology, medicine.disease_cause, medicine.anatomical_structure, Cohort, Immunology, microRNA, Emergency Medicine, medicine, TaqMan, Microrna profiling
Abstract

Background: Circulating miRNAs are recently used as promising biomarkers for infectious diseases. The aim of this study was to identify plasma miRNAs for infection detection and monitoring the immune status of HIV infection. Methods: A cohort of 128 plasma samples from HIV-1 infected subjects and 37 samples from healthy donors were analyzed by TaqMan Low-Density Array (TLDA) method to find the differentially expressed miRNAs, in the light of HIV-1infected patients with low ( 350 cell/μL) CD4+ T cell count. Results: Seven miRNAs (miR-29a, miR-223, miR-27a, miR-19b, miR-151-3p, miR-28-5p, miR-766 and miR-30a-3p) were significantly associated with CD4+ T cell count (P Conclusions: We have identified highly sensitive and specific signatures of circulating miRNAs enabling non invasive detection and immune status monitoring of HIV-1 infection.

Published
2017
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38. First report of two rapid-onset fatal infections caused by a newly emerging hypervirulent K. Pneumonia ST86 strain of serotype K2 in China

Author

Zhang, Yibo, primary, Sun, Jingyong, additional, Mi, Chenrong, additional, Li, Wenhui, additional, Zhao, Shengyuan, additional, Wang, Qun, additional, Shi, Dake, additional, Liu, Luo, additional, Ding, Bingyu, additional, Chang, Yung-Fu, additional, Guo, Hongxiong, additional, Guo, XiaoKui, additional, Li, Qingtian, additional, and Zhu, Yongzhang, additional

Published
2015
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39. The Epidemic of HIV, Syphilis, Chlamydia and Gonorrhea and the Correlates of Sexual Transmitted Infections among Men Who Have Sex with Men in Jiangsu, China, 2009

Author

Fu, Geng-Feng, primary, Jiang, Ning, additional, Hu, Hai-Yang, additional, Mahapatra, Tanmay, additional, Yin, Yue-Ping, additional, Mahapatra, Sanchita, additional, Wang, Xiao-Liang, additional, Chen, Xiang-Sheng, additional, Babu, Giridhar R., additional, Xu, Xiao-Qin, additional, Ding, Ping, additional, Qiu, Tao, additional, Liu, Xiao-Yan, additional, Guo, Hongxiong, additional, Huan, Xi-Ping, additional, and Tang, Weiming, additional

Published
2015
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48. High Prevalence of Antibiotic Resistance and Molecular Characterization of Integrons among ShigellaIsolates in Eastern China

Author

Shen, Yun, Qian, Huimin, Gong, Junjun, Deng, Feifei, Dong, Chen, Zhou, Lu, and Guo, Hongxiong

Abstract

ABSTRACTA total of 747 Shigellaisolates were collected from hospitals in Jiangsu Province of China. Susceptibilities to antimicrobials and integrons were tested. A total of 78.3% of S. flexneriisolates and a total of 74.3% S. soneiisolates were resistant to at least three antibiotics. Of the Shigellaisolates, 74.7% had integron I and 82.6% had integron II. The conjunction of the high prevalence of integrons in Shigellaand high resistance to antimicrobials will lead to rapid dissemination of resistant genes in this region.

Published
2012
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49. [Epidemiological characteristics of HIV/AIDS patients newly received highly active antiretroviral therapy during 2005-2013 in Jiangsu province].

Author

Qiu T, Ding P, Liu X, Xu J, Guo H, Fu G, Xu X, and Huan X

Subjects
Adult, CD4 Lymphocyte Count, China epidemiology, Communicable Diseases, Female, HIV Infections, Humans, Male, Acquired Immunodeficiency Syndrome drug therapy, Acquired Immunodeficiency Syndrome epidemiology, Antiretroviral Therapy, Highly Active
Abstract

Objective: To analyze the epidemiological characteristics of the HIV/AIDS patients newly received highly active antiretroviral therapy (HAART) during 2005-2013 in Jiangsu province., Methods: According to the baseline data of HIV/AIDS patients newly received HAART during 2005-2013, an Excel database was established and statistical analysis was performed using SPSS 16.0 software., Results: There were 5 788 HIV/AIDS patients newly received HAART during 2005-2013 and the number increased annually. 79.7% of these patients were from the local province, with the ratio of male to female as 4.69 : 1, mean age as 39.9 years old, 55.8% of them married, 52.0% of them were treated at CDC. 91.9% of them were infected through sexual contacts. Mean baseline CD4(+)T cell count of cases was 187 cells/µl. Median of the interval between the time of HIV confirmation and HAART initiation was 4.0 months. Proportion of the HIV/AIDS patients that were being male, elderly, unmarried, not local resident, treated in hospitals and with higher baseline CD4(+)T count etc. showed a trend of increase., Conclusion: HIV/AIDS patients had the opportunity to start the HAART at early stage of the disease. However, many of them started the treafment late as the results of being diagnosed late. Programs related to both earlier detection and diagnosis on HIV cases should be strengthened.

Published
2014

50. [Analysis of the five-year effectiveness of highly active antiretroviral therapy among 200 HIV/AIDS patients in Jiangsu province].

Author

Qiu T, Ding P, Liu X, Guo H, Fu G, Xu X, Huan X, and Yang H

Subjects
Female, Follow-Up Studies, Humans, Male, Acquired Immunodeficiency Syndrome, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, HIV Infections
Abstract

Objective: To analyze the five-year effectiveness of the people living with HIV/AIDS who initially received highly active antiretroviral therapy (HAART) in Jiangsu province., Methods: HIV/AIDS initially received HAART from 1 Jan 2005 to 31 May 2014 in Jiangsu province with the CD4(+)T cell count tested in baseline, 6 months, 1 year, 2 years, 3 years, 4 years and 5 years after treatment initiation were selected. According to their retrospectively collected baseline and follow-up data, statistical analysis was performed using SPSS 16.0 software to analyze the variation of CD4(+)T counts and its impact factors in different times after treatment initiation., Results: A total of 200 patients were included. A total of 134 patients were men, and 66 were women, the ratio of male to female was 2.03: 1; mean age was (39.7 ± 10.3) years old; 69.0% (138/200) of the patients married; 53.0% (106/200) as the most were infected with HIV through heterosexual transmission, and followed by men who have sex with men (MSM) (25.5%, 51/200); taken together as 78.5% (157/200).58.5% (117/200) were treated in the CDC. The mean (95%CI) baseline CD4(+)T cell count of cases was 106.9 (93.3-120.5) cells/µl; the CD4(+)T count tested in 6 months, 1 year, 2 years, 3 years, 4 years and 5 years after treatment initiation were 107.3, 152.9, 221.6, 260.0, 281.3 and 316.4 cells/µl more than baseline respectively; the CD4(+)T count after treatment initiation has increased over time (F = 201.06, P < 0.01) . The mean(95%CI) CD4(+)T count tested in 5 years after treatment initiation can increase to 540.7(445.4-635.9) cells/µl with a baseline CD4(+)T count more than 200 cells/µl, but in the subgroups with a baseline CD4(+)T count less than or equal to 50 cells/µl, 51-100 cells/µl, 101-150 cells/µl and 151-200 cells/µl, it only can reach to 431.4 (375.9-487.0), 400.0 (339.9-460.2), 380.3 (330.6-430.0) and 412.1 (369.3-454.8) cells/µl respectively. The mean (95%CI) CD4(+)T count tested in 5 years after treatment initiation with 1 baseline symptom categories can increase to 449.2 (392.2-506.2) cells/µl, while 409.1(317.8-500.5)cells/µl in the subgroup with baseline symptom categories more than or equal to 2. The CD4(+)T after treatment increased slowly associated with a lower baseline CD4(+)T count level and more baseline symptom categories (F values were 3.96 and 2.35, P < 0.01)., Conclusion: It has a remarkable effectiveness for HIV/AIDS treatment in Jiangsu province. The patients with a baseline CD4(+)T count more than 200 counts/µl have a better immune function recovery.

Published
2014

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