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Your search keyword '"Guo, Lin-Yun"' showing total 8 results
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8 results on '"Guo, Lin-Yun"'

5. Additional file 1: of Continuous exposure of isoprenaline inhibits myoblast differentiation and fusion through PKA/ERK1/2-FOXO1 signaling pathway

Author

Chen, Shao-Juan, Yue, Jing, Jing-Xuan Zhang, Jiang, Miao, Tu-Qiang Hu, Leng, Wei-Dong, Xiang, Li, Li, Xin-Yuan, Zhang, Lei, Zheng, Fei, Yuan, Ye, Guo, Lin-Yun, Ya-Mu Pan, Yan, Yu-Wen, Wang, Jia-Ning, Chen, Shi-You, and Tang, Jun-Ming

Subjects
musculoskeletal system, tissues
Abstract

Figure S1. Continuous single-dose ISO obviously inhibited C2C12 cell differentiation and myoblast fusion than single-dose ISO. Figure S2. Continuous ISO stimulation altered myoblast fusion competence of myotube during C2C12 cell differentiation. Figure S3. Continuous single ISO involved in C2C12 cell differentiation and muscle fiber types through FoxO1 signaling. Figure S4. Continuous single ISO did not alter levels of PKA α cat, PKA α/β/ϒ cat, PKA ϒ cat in C2C12 cell differentiation. (DOCX 519 kb)

Published
2019
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8. Acetylcholine induces mesenchymal stem cell migration via Ca2+ /PKC/ERK1/2 signal pathway.

Author

Tang JM, Yuan J, Li Q, Wang JN, Kong X, Zheng F, Zhang L, Chen L, Guo LY, Huang YH, Yang JY, and Chen SY

Subjects
Animals, Blotting, Western, Cell Movement physiology, Cell Proliferation drug effects, Male, Mesenchymal Stem Cells drug effects, Rats, Rats, Sprague-Dawley, Receptors, Muscarinic metabolism, Signal Transduction drug effects, Acetylcholine pharmacology, Calcium metabolism, MAP Kinase Signaling System drug effects, Mesenchymal Stem Cells cytology, Protein Kinase C metabolism
Abstract

Acetylcholine (ACh) plays an important role in neural and non-neural function, but its role in mesenchymal stem cell (MSC) migration remains to be determined. In the present study, we have found that ACh induces MSC migration via muscarinic acetylcholine receptors (mAChRs). Among several mAChRs, MSCs express mAChR subtype 1 (m1AChR). ACh induces MSC migration via interaction with mAChR1. MEK1/2 inhibitor PD98059 blocks ERK1/2 phosphorylation while partially inhibiting the ACh-induced MSC migration. InsP3Rs inhibitor 2-APB that inhibits MAPK/ERK phosphorylation completely blocks ACh-mediated MSC migration. Interestingly, intracellular Ca(2+) ATPase-specific inhibitor thapsigargin also completely blocks ACh-induced MSC migration through the depletion of intracellular Ca(2+) storage. PKCα or PKCβ inhibitor or their siRNAs only partially inhibit ACh-induced MSC migration, but PKC-ζ siRNA completely inhibits ACh-induced MSC migration via blocking ERK1/2 phosphorylation. These results indicate that ACh induces MSC migration via Ca(2+), PKC, and ERK1/2 signal pathways., (Copyright © 2012 Wiley Periodicals, Inc.)

Published
2012
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