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Photoelectric sensors based on charge‐coupled device (CCD) and complementary‐metal‐oxide‐semiconductor (CMOS) used to be planar image sensors due to the rigidity of the base materials. Moreover, they are limited to a narrow reaction wavelength range. Here, a conformal broad‐spectra laser sensor based on a flexible metal‐ferroelectric‐metal photocapacitor is promoted. The photocapacitance signal is attributed to the photothermal effect of copper (Cu) electrode and gold nanoparticles (Au NP), and the temperature‐dependent property of the dielectric constant of poly(vinylidene fluoride‐trifluoroethylene) (PVDF‐TrFE). Cu/PVDF‐TrFE/Cu and Cu/Au NP@PVDF‐TrFE/Cu flexible photocapacitors have a reliable photocapacitive response from −60 to 60 °C. Meanwhile, both photocapacitors respond from 265 to 980 nm due to the absorption of light by the composite structure, which can be used for broad‐spectra photodetection. The addition of a small amount of Au NP (0.05 vol%) effectively improves the photoresponsiveness of the device. Real‐time photodetection is realized on a hemispherical surface, and these photocapacitors with conformal characteristics are expected to gain application in an omnidirectional broad‐spectra laser alarming system. [ABSTRACT FROM AUTHOR]

Background: Severe carotid stenosis is a common cause of stroke. In addition, previous clinical studies revealed that patients symptomatic of carotid stenosis suffer from increased episodes of stroke compared with their asymptomatic counterparts. However, the mechanism underlying these differences in the recurrence of stroke remains unclear. Objective: The present study aimed to evaluate the levels of neutrophil extracellular traps (NETs) in the plasma of patients with severe carotid stenosis and investigate whether NETs induced procoagulant activity (PCA) in severe carotid stenosis. The study also sought to investigate the interactions between platelets or endothelial cells (ECs) and NETs. Methods: The levels of NETs in plasma were quantified using enzyme‐linked immunosorbent assay (ELISA). In addition, NETting neutrophils and neutrophil‐platelet aggregates were detected through flow cytometry. On the other hand, the morphology of NETs formation and endothelial cells were analyzed through confocal microscopy. Finally, the procoagulant activity (PCA) of NETs and endothelial cells were assessed through ELISA and fibrin formation. Results: Patients with symptomatic carotid stenosis patients had significantly higher levels of NETs markers compared with their asymptomatic counterparts and healthy subjects. In addition, increased levels of neutrophil‐platelet aggregates induced the generation of NETs in patients with symptomatic carotid stenosis. Moreover, NETs contributed to PCA through tissue factor (TF), in patients with carotid stenosis. Furthermore, NETs disrupted the endothelial barrier and converted endothelial cells (ECs) into PCA to enhance the PCA in patients with carotid stenosis. Conclusions: The current study revealed differences in the levels of NETs in the plasma of symptomatic and asymptomatic patients suffering from carotid stenosis. The study also uncovered the interaction between NETs and thrombogenicity in carotid stenosis. Therefore, inhibiting NETs may be a potential biomarker and therapeutic target for recurring stroke in severe carotid stenosis. [ABSTRACT FROM AUTHOR]

Large roughness and structure disorder in ferroelectric ultrathin Langmuir–Blodgett film had been limiting the nanoscale research and reliability of nano-devices. However, no effective method aiming at large-area uniform organic ferroelectric LB film has ever been reported to date. Herein, we present a facile hot-pressing strategy to prepare relatively large-area PVDF LB film with atomic-smooth surface, less fluctuation in ferroelectric characteristics and improved dielectric and piezoelectric responses, which endows PVDF LB film with unprecedented reliability and improved performance as a competitive candidate for future ferroelectric tunnel junctions (FTJs) and nano electro mechanical systems (NEMS). Besides, different surface charge relaxation behaviors are investigated and the underlying mechanisms are explained in the light of the interplay of surface charge and polarization charge in the case of nanoscale non-uniform switching. [Display omitted] Large roughness and structure disorder in ferroelectric ultrathin Langmuir-Blodgett (LB) film results in severe space scatter in electrical, ferroelectric and piezoelectric characteristics, thus limiting the nanoscale research and reliability of nano-devices. However, no effective method aiming at large-area uniform organic ferroelectric LB film has ever been reported to date. Herein, we present a facile hot-pressing strategy to prepare relatively large-area poly(vinylidene fluoride) (PVDF) LB film with ultra-smooth surface root mean square (RMS) roughness is 0.3 nm in a 30 μm × 30 μm area comparable to that of metal substrate, which maximized the potential of LB technique to control thickness distribution. More importantly, compared with traditionally annealed LB film, the hot-pressed LB film manifests significantly improved structure uniformity, less fluctuation in ferroelectric characteristics and higher dielectric and piezoelectric responses, owing to the uniform dipole orientation and higher crystalline quality. Besides, different surface charge relaxation behaviors are investigated and the underlying mechanisms are explained in the light of the interplay of surface charge and polarization charge in the case of nanoscale non-uniform switching. We believe that our work not only presents a novel strategy to endow PVDF LB film with unprecedented reliability and improved performance as a competitive candidate for future ferroelectric tunnel junctions (FTJs) and nano electro mechanical systems (NEMS), but also reveals an attracting coupling effect between the surface potential distribution and nanoscale non-uniform switching behavior, which is crucial for the understanding of local transport characterization modulated by band structure, bit signal stability for data-storage application and the related surface charge research, such as charge gradient microscopy (CGM) based on the collection of surface charge on the biased ferroelectric domains. [ABSTRACT FROM AUTHOR]

Polar topological texture has become an emerging research field for exotic phenomena and potential applications in reconfigurable electronic devices. We report toroidal topological texture self-organized in a ferroelectric polymer, poly(vinylidene fluoride-ran-trifluoroethylene) [P(VDF-TrFE)], that exhibits concentric topology with anticoupled chiral domains. The interplay among the elastic, electric, and gradient energies results in continuous rotation and toroidal assembly of the polarization perpendicular to polymer chains, whereas relaxor behavior is induced along polymer chains. Such toroidal polar topology gives rise to periodic absorption of polarized far-infrared (FIR) waves, enabling the manipulation of the terahertz wave on a mesoscopic scale. Our observations should inform design principles for flexible ferroic materials toward complex topologies and provide opportunities for multistimuli conversions in flexible electronics. [ABSTRACT FROM AUTHOR]

The AgNPs@NCN composite was prepared by loading silver nanoparticles (AgNPs) onto the surface of carbon nitride (g-C 3 N 4) with nitrogen-vacancy and cyanide defect and used for the synergistic degradation of methylene blue (MB) by the structural defect of g-C 3 N 4 , the surface plasmon resonance of AgNPs and Schottky barrier formed between them. The morphology, structure, chemical composition and photoelectrochemical properties were characterized by SEM, TEM, FTIR, XRD, XPS, BET and UV–Vis. The effects of different loads of AgNPs on photocatalytic performance were investigated and the results showed 10%AgNPs@NCN exhibited good photodegradation performance. The maximum degradation efficiency of MB by 10%AgNPs@NCN reached 100% with the rate constant of 0.05443 min−1, which was 9.15 and 6.89 times higher than those of g-C 3 N 4 (0.00595 min−1) and NCN (0.0079 min−1), respectively. The mineralization degree of organic pollutants was evaluated by total organic carbon (TOC) and the results showed that the TOC removals of 10%AgNPs@NCN photocatalytic reaction were 77% and 93% for MB and wastewater, respectively. After four cycles of photocatalytic degradation experiments, the degradation rate of MB was still more than 98.2% and there was no significant change in the characteristic stretching of the catalyst, indicating that the prepared photocatalyst had good stability and reusability. Synergistic degradation of MB based on AgNPs@NCN. Due to the synergistic effect of the nitrogen-vacancy and cyanogen defect of NCN, the surface plasmon resonance of AgNPs and Schottky barrier formed between them, the effective degradation of methylene blue (MB) by AgNPs@NCN composite under visible light irradiation is realized. Under simulated sunlight irradiation, AgNPs@NCN photocatalyst could degrade 100% MB in the solution in 60 min, and the degradation rate was 15.3 and 11.5 times that of g-C 3 N 4 and NCN. [Display omitted] • AgNPs@NCN was prepared by depositing AgNPs on g-C 3 N 4 with structural defect. • The synergistic degradation of MB is realized by structural defect, AgNPs and Schottky barrier. • Under simulated sunlight irradiation, AgNPs@NCN could degrade 100% MB in 60 min. • The proposed method based on the AgNPs@NCN for degrading MB showed high stability. [ABSTRACT FROM AUTHOR]

Emerging dielectric composites consisting of polymer and ceramic nano-inclusions or several polymers facilitate the development of capacitive energy storage materials, as they can preserve high breakdown strength and exhibit enhanced dielectric constant. Ferroelectric poly(vinylidene fluoride) (PVDF) and its copolymers have been intensively studied as the matrices because of their high intrinsic dielectric constant and breakdown strength. Here, we review the recent advances on improving the energy density of PVDF-based composite dielectrics. It is concluded that, promotion of energy density is mainly established on enhanced breakdown strength and improved discharge efficiency. The microstructure design, material performance, and mechanism associated with these parameters are described. Perspectives for future development on PVDF-based nanocomposites and application of other potential polymer matrices are presented at last. [ABSTRACT FROM AUTHOR]

Nanomaterials have been widely utilized in human daily life. The interaction between nanoparticles (NPs) and food matrices through oral ingestion is important for fate and potential toxicity of NPs. In this study, the interaction between NPs (i.e., titanium dioxide (TiO 2) and zinc oxide (ZnO)) and food matrices (namely sucrose, protein powder, and corn oil) was investigated by use of an in vitro physiological model. Measurement using asymmetrical flow field-flow fractionation (AF 4) showed that particle size of TiO 2 NPs in saliva fluid decreased from 102 ± 6.21 nm (control) to 69.2 ± 6.90 and 81.9 ± 4.30 nm in protein powder and corn oil. Similar trend was also observed for ZnO. Compared with gastric fluid, micelles formed by corn oil in intestinal fluid further dispersed NPs, as indicated by approximately 11.1% and 13.2% decrease in particle size of TiO 2 and ZnO NPs, respectively. Characterization of TEM, FTIR and AFM showed that a layer of biological corona was attached on surface of NPs in protein and oil. The XPS demonstrated that oil bound with NPs through forming covalent bonds, while protein bound with NPs through van der Waals force and electrostatic force for TiO 2 and ZnO NPs, respectively. The result here demonstrated the importance of considering food effect when investigating the morphology and behavior of NPs after oral ingestion. This understanding was valuable in assessment of environmental fate and biological effects of NPs. Image 1 • Behaviors of TiO 2 and ZnO nanoparticles (NPs) in digestive tract were investigated under the influence of food. • Protein and oil significantly decreased NP particle size in saliva, and oil dispersed NPs in intestinal fluid due to micelle. • AF 4 -MALS was more suitable for analysis of NP particle size in complex matrices compared with DLS and SEM. • Oil bound with NPs through covalent bonds, while protein through van der Waals force and electrostatic force. [ABSTRACT FROM AUTHOR]

The application of BiOCl in photocatalysis has been restricted by its low utilization of solar energy and fast recombination of charge carriers. In this study, zero-dimensional (0D) Bi2WO6 nanoparticles/two-dimensional (2D) layered BiOCl heterojunction composite was successfully constructed by facile hydrothermal and solvothermal methods. The most favorable sunlight photocatalytic activity was achieved for the as-prepared Bi2WO6–BiOCl composites with a ratio of 1%. The photocatalytic rate and mineralization efficiency of one typical antibiotic (i.e., oxytetracycline) over 1% Bi2WO6–BiOCl was about 2.7 and 5.3 times as high as that of BiOCl. Both experimental characterizations and density functional theory (DFT) calculations confirmed that the excellent photocatalytic performance mainly arised from the effective charge separation along the Bi2WO6 and BiOCl heterojunction interface. The effective electron transfer was driven by the internal electric field at the interfacial junction. In addition, 1% Bi2WO6–BiOCl exhibited excellent stability, and no apparent deactivation was observed after 4 test cycles. Therefore, the 0D/2D Bi2WO6–BiOCl heterojunction showed a great potential for the photocatalytic degradation of emerging organic pollutants. [ABSTRACT FROM AUTHOR]

Novel brominated flame retardants (NBFRs) have been widely used and frequently detected in various environmental matrices. In this study, 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB), bis-(2-ethylhexyl) tetrabromophthalate (TBPH) and their metabolites (namely 2,3,4,5-tetra-bromo benzoic acid (TBBA) and mono(2-ethylhexyl) tetrabromophthalate (TBMEHP)) were exposed to human umbilical vein endothelial cells (HUVECs). Metabolites can induce stronger cytotoxicity than parent compounds with EC50 at 47.3 (TBBA), 8.6 μg/ml (TBMEHP) vs > 200 μg/mL for parent compounds. Gene expression of platelet endothelial cell adhesion molecule-1, the gene associated with blood platelet kinetics, was significantly induced under TBBA and TBMEHP exposure. The in vivo test was consistent with gene expression result that the number of platelets in mouse blood was significantly increased after gavaged with 0.8 μg/mL TBBA and TBMEHP. In addition, TBB or TBPH were exposed to mice via gavage, and higher concentrations of TBBA (4 h, 60.8 ± 12.9 ng/mL, 8 h, 69.4 ± 2.24 ng/mL) in mouse blood were found than those of TBMEHP (4 h, 17.2 ± 4.01 ng/mL, 8 h, 12.8 ± 3.20 ng/mL), indicating that TBB was more readily in vivo metabolized than TBPH. The in vivo metabolism of TBB and TBPH and the stronger toxicity of their metabolites underscore the potential risk through NBFR exposure and the importance of understanding NBFR metabolism process. Image 1 • TBBA and TBMEHP induced stronger cytotoxicity in HUVECs than parent compounds (TBB and TBHP). • TBBA and TBMEHP significantly induced PECAM-1 expression, and increased the number of platelets in mouse blood. • TBB was more readily in vivo metabolized than TBPH. [ABSTRACT FROM AUTHOR]

Catalpa bungei is a precious timber species distributed in North China where drought often occurs. To clarify adaptive responses of C. bungei to partial- and full- root-zone drought under the influence of nitrogen forms, a two-factor experiment was conducted in which well-watered (WW), partial root-zone drought in horizontal direction (H-PRD) and in vertical direction (V-PRD), and full root-zone drought (FRD) were combined with nitrate-nitrogen (NN) and ammonium-nitrogen (AN) treatments. C. bungei responded to FRD by sharply closing stomata, decreasing gas exchange rate and increasing leaf instantaneous water use efficiency (WUEi). Under FRD condition, the growth of seedlings was severely inhibited and the effect of N forms was covered up by the drastic drought effect. In comparison, stomata conductance and gas exchanges were moderately inhibited by PRDs. WUEi in V-PRD treatment was superior to H-PRD due to the active stomata regulation resulting from a higher ABA level and active transcription of genes in abscisic acid (ABA) signaling pathway under V-PRD. Under both PRDs and FRD, nitrate benefited antioxidant defense, stomata regulation and leaf WUEi. Under V-PRD, WUEi in nitrate treatment was superior to that in ammonium treatment due to active stomata regulation by signaling network of nitric oxide (NO), Ca2+ and ABA. Under FRD, WUEi was higher in nitrate treatment due to the favoring photosynthetic efficiency resulting from active NO signal and antioxidant defense. The interactive effect of water and N forms was significant on wood xylem development. Superoxide dismutase (SOD) and catalase (CAT) largely contributes to stress tolerance and xylem development. [ABSTRACT FROM AUTHOR]

Ferroelectric memories are endowed with high data storage density by nanostructure designing, while the robustness is also impaired. For organic ferroelectrics favored by flexible memories, low Curie transition temperature limits their thermal stability. Herein, a ferroelectric random access memory (FeRAM) is demonstrated based on an array of P(VDF‐TrFE) lamellae by self‐assembly. Written data shows enhanced thermal endurance up to 90 °C and undergoes 12 thermal cycles between 30 and 80 °C with little volatilization. The promoted thermal stability is attributed to pinning effect at interfaces between grain boundaries and lamellae, where charged domain walls and charged defects are coupled. These results provide a strategy for improving robustness of organic flexible FeRAMs, and reveal an attracting coupling effect between different phases of ferroelectric polymer. Thermal stability of organic ferroelectric memories is prominent due to their low Curie transition temperature. In this work, ferroelectric random access memory with enhanced thermal stability is achieved based on an array of lamellae by self‐assembly. By switching spectrum a piezoresponse force microscope and scanning Kelvin probe microscope, the mechanism of enhanced thermal stability is presented. [ABSTRACT FROM AUTHOR]

With the increasing demand for energy, how to store and release energy efficiently and stably has become an urgent research topic. Polymer dielectrics have become a kind of ideal dielectric materials in electrostatic capacitors for energy storage due to their advantages of light weight, easy fabrication, low cost, and high breakdown strength. It has a wide application prospect in smart power grids, new energy vehicles, pulse power weapons, electromagnetic guns, and lasers. However, existing polymer dielectrics cannot simultaneously possess the characteristics of high energy density, high breakdown field intensity, high charge and discharge efficiency, and low dielectric loss, thus limiting the development of compact, efficient, and reliable electronic power technology. In addition, the inherent thermal/field charge injection, excitation, and transport phenomena of polymer dielectrics make the resistivity and dielectric energy storage properties of polymer dielectrics decrease sharply under the combined action of high temperature and high electric field. In order to optimize the energy storage performance of polymer dielectrics (including room temperature and high temperature dielectrics), it has been obtained excellent dielectric breakdown strength, energy storage density, energy storage charge, and discharge efficiency from polymer nanocomposites, polymer/small molecule composites, polymer/polymer blends, new synthetic polymers, multilayer polymers, and other material systems. Based on these material systems, this review summarizes and compares these material systems, points out their advantages and disadvantages including the key problems, and puts forward suggestions for the future research. [ABSTRACT FROM AUTHOR]

Flexible piezoelectric materials capable of withstanding large deformation play key roles in flexible electronics. Ferroelectric ceramics with a high piezoelectric coefficient are inherently brittle, whereas polar polymers exhibit a low piezoelectric coefficient. Here we report a highly stretchable/compressible piezoelectric composite composed of ferroelectric ceramic skeleton, elastomer matrix and relaxor ferroelectric-based hybrid at the ceramic/matrix interface as dielectric transition layers, exhibiting a giant piezoelectric coefficient of 250 picometers per volt, high electromechanical coupling factor keff of 65%, ultralow acoustic impedance of 3MRyl and high cyclic stability under 50% compression strain. The superior flexibility and piezoelectric properties are attributed to the electric polarization and mechanical load transfer paths formed by the ceramic skeleton, and dielectric mismatch mitigation between ceramic fillers and elastomer matrix by the dielectric transition layer. The synergistic fusion of ultrahigh piezoelectric properties and superior flexibility in these polymer composites is expected to drive emerging applications in flexible smart electronics. [ABSTRACT FROM AUTHOR]

Tetrabromobisphenol A (TBBPA) has attracted considerable attention due to its ubiquitous presence in different environmental compartments worldwide. However, information on its aerobic biodegradability in coastal environments remains unknown. Here, the aerobic biodegradation of TBBPA using a Pseudoalteromonas species commonly found in the marine environment was investigated. We found that extracellular biogenic siderophore, superoxide anion radical (O 2 •− ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radical ( • OH) were involved in TBBPA degradation. Upregulation of genes ( nqrA and lodA ) encoding Na + -translocating NADH-quinone oxidoreductase and l -lysine-ε-oxidase supported the extracellular O 2 •− and H 2 O 2 production. The underlying mechanism of TBBPA biodegradation presumably involves both O 2 •− reduction and • OH-based advanced oxidation process (AOP). Furthermore, TBBPA intermediates of tribromobisphenol A, 4-isopropylene-2,6-dibromophenol, 4-(2-hydroxyisopropyl)-2,6-dibromophenol, 2,4,6-tribromophenol (TBP), 4-hydroxybenzoic acid, and 2-bromobenzoic acid were detected in the culture medium. Debromination and β -scission pathways of TBBPA biodegradation were proposed. Additionally, membrane integrity assays revealed that the increase of intracellular catalase (CAT) activity and the extracellular polymeric substances (EPS) might account for the alleviation of oxidative damage. These findings could deepen understanding of the biodegradation mechanism of TBBPA and other related organic pollutants in coastal and artificial bioremediation systems. [ABSTRACT FROM AUTHOR]

The peripheral T cell pool is maintained at dynamic homeostasis through fine‐tuning of thymic output and self‐renewal of naïve T cells. Lymphopenia or reduced lymphocyte number is implicated in autoimmune diseases, yet little is known about the homeostatic mechanisms. Here, it is reported that the replication protein A1 (RPA1) plays a critical role in T cell homeostasis. Utilizing T cell‐specific Rpa1‐deficient (Rpa1fl/fl Cd4‐cre) mice, loss of Rpa1 results in lymphopenia through restraining peripheral T cell population and limiting TCR repertoire diversity. Moreover, Rpa1fl/fl Cd4‐cre mice exhibit increased susceptibility to inflammatory diseases, including colitis and hepatitis. Clinical analysis reveals that the expression of RPA1 is reduced in patients with ulcerative colitis or other autoinflammatory diseases. Mechanistically, depletion of RPA1 activates ZBP1‐RIPK3 signaling through triggering the genomic DNA leakage into cytosol, consequently resulting in T cell necroptosis. This necroptotic T cell death induced by RPA1 deficiency allows the release of damage‐associated molecular patterns (DAMPs), which in turn recruits leukocytes and exacerbates inflammatory response. Reciprocally, chemical or genetic inhibition of necroptosis signaling can ameliorate the Rpa1 deficiency‐induced inflammatory damage. The studies thus uncover the importance of RPA1‐ZBP1‐RIPK3 axis in T cell homeostasis and provide a promising strategy for autoinflammatory disease treatment. [ABSTRACT FROM AUTHOR]

Polymer dielectrics with high breakdown strength (Eb) and high efficiency are urgently demanded in advanced electrical and electronic systems, yet their energy density (Ue) is limited due to low dielectric constant and high loss at elevated temperatures. Conventional inorganic fillers with diameters from nano to micrometers can only increase er at the cost of compromised Eb and Ue due to their poor compatibility with polymer matrix. Herein, hydroxyapa-tite (HAP) sub-nanowires with a diameter of "0.9 nm are incorporated in polyetherimide (PEI) matrix to form HAP/PEI sub-nanocomposites. er and Eb of the composites are concomitantly enhanced with only 0.5 wt.% of HAP sub-nanowires, leading to high Ue of 5.14 (@150 °C) and 3.1 J cm-3 (@200 °C] with efficiency of 90% and high-temperature stability up to 3 x 105 chargedischarge cycles at 200 °C. Microstructural analysis and molecular dynamics simulations indicate that the sub-nanowires with comparable diameter as polymer chains induce enormous interfacial area, substantially increase mobility of polymer chains and form dense traps for charge carriers. This work extends the current research scope of polymer-inorganics composite dielectrics to the sub-nano-level incorporation and provides a novel strategy for fabricating high performance polymer dielectrics at elevated temperatures [ABSTRACT FROM AUTHOR]

Abstract: Metallic transition metal dichalcogenides (TMDs) have exhibited various exotic physical properties and hold the promise of novel optoelectronic and topological devices applications. However, the synthesis of metallic TMDs is based on gas‐phase methods and requires high‐temperature condition. As an alternative to the gas‐phase synthetic approach, lower temperature eutectic liquid‐phase synthesis presents a very promising approach with the potential for larger‐scale and controllable growth of high‐quality thin metallic TMD single crystals. Here, the first realization of low‐temperature eutectic liquid‐phase synthesis of type‐II Dirac semimetal PtTe2 single crystals with thickness ranging from 2 to 200 nm is presented. The electrical measurement of synthesized PtTe2 reveals a record‐high conductivity of as high as 3.3 × 106 S m−1 at room temperature. Besides, the weak antilocalization behavior is identified experimentally in the type‐II Dirac semimetal PtTe2 for the first time. Furthermore, a simple and general strategy is developed to obtain atomically thin PtTe2 crystal by thinning as‐synthesized bulk samples, which can still retain highly crystalline and exhibits excellent electrical conductivity. The results of controllable and scalable low‐temperature eutectic liquid‐phase synthesis and layer‐by‐layer thinning of high‐quality thin PtTe2 single crystals offer a simple and general approach for obtaining different thickness metallic TMDs with high melting‐point transition metal. [ABSTRACT FROM AUTHOR]

Accordingly, chemical or genetic inhibition of necroptosis signaling can ameliorate the inflammatory damage by Rpa1 deficiency and restore host immune homeostasis. B T Cell homeostasis b The article number 2206344 by Yuxin Yin, Xuehui Zhang, Xuliang Deng, Dan Lu, and co-workers uncovers that peripheral T cells can undergo necroptosis instead of apoptosis when endogenous RPA1 is deleted, which leads to severe lymphopenia and increases the susceptibility of autoinflammatory diseases. [Extracted from the article]